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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Translational Neuroscience of Speech and Language Disorders: State of the Art. -2. Translational Neuroscience of Aphasia and Adult Language Rehabilitation. -3. Treatment and intervention approaches for the improvement of language abilities in neurodegenerative diseases -- 4. Neural and Genetic Mechanisms of Dyslexia -- 5. The role of memory systems in neurodevelopmental disorders of language -- 6. Transcranial direct current stimulation (tDCS) and Language/Speech: Can patients benefit from a combined therapeutic approach? -- 7. Transcranial Magnetic Stimulation in Aphasia Rehabilitation -- 8. The Cerebellum: A Therapeutic Target in Treating Speech and Language Disorders -- 9. Navigated rTMS for Mapping the Language Network in Preoperative Settings: Current Status and Future Prospects -- 10. Presurgical Language fMRI in Epilepsy: An Introduction -- 11. Lesion-symptom mapping in speech and language disorders: a translational perspective.
    Abstract: This edited volume provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative conditions on speech and language. It brings together contributions from several leading experts in a markedly broad range of disciplines, including Speech and Language Therapy, Neuropsychology and Neurology, but also Neurosurgery, Neuroimaging and Neurostimulation, as well as Engineering and Genetics.
    Type of Medium: Online Resource
    Pages: XVII, 290 p. 18 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356873
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 2
    Keywords: Medical genetics. ; Genetics. ; Biotechnology. ; Medical Genetics. ; Genetics and Genomics. ; Chemical Bioengineering.
    Description / Table of Contents: Section I: The physiology of the gene/environment interaction -- Nutrition -- Physical Exercise -- Circadian Rhythm -- Toxicants: Smoke, Alcohol and Heavy Metals -- Hormones -- Section II: Gene-Environment Interaction and Disease Susceptibility -- Obesity and Metabolic Syndromes -- Cancer -- Neurological and Psychiatric Disorders -- Asthma and allergic disorders -- Lamarck Versus Darwin: The Concept of Aquired Epigenetic Inheritance -- Section III: Genome/Epigenome -- Genetic Contribution to Epigenetic Inheritance -- The Controversial Role of DNA Methylation in Epigenetic Inheritance -- Small Non-Coding RNAs -- Chromatin Modifiers -- Soma-to-Germline Information Transfer: Questions and Promises.
    Abstract: The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.
    Type of Medium: Online Resource
    Pages: VIII, 266 p. 11 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030352134
    DDC: 616.042
    Language: English
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  • 3
    Keywords: Conservation biology. ; Ecology . ; Molecular ecology. ; Animal migration. ; Animal culture. ; Biodiversity. ; Biotic communities. ; Population biology. ; Conservation Biology. ; Molecular Ecology. ; Animal Migration. ; Animal Science. ; Biodiversity. ; Community and Population Ecology.
    Description / Table of Contents: (1) Introduction on different applications of molecular tools to answer novel questions in the field of population genetics/genomics of endangered mammals (Mike Bruford, School of Biosciences, Cardiff University, UK) -- (2) Climate change impact at the genetic level: patterns in the Couesi's rice rat Oryzomys couesi (Ella Vázquez Domínguez, Instituto de Ecología, UNAM, Mexico) -- (3) Use of molecular and demographic data to prioritize populations of black-tailed prairie dogs (Cynomys ludovicianus) from Chihuahua, Mexico for conservation (Luis Eguiarte Fruns, Instituto de Ecología, UNAM, Mexico) -- (4) Anthropogenic and Historic Movements of American Black Bears Shape Contemporary Population Structure (Emily Puckett, Division of Molecular Sciences, University of Missouri, USA) -- (5) How many ESUs are of conservation interest within some species of Neotropical carnivores (Felidae, Canidae, Ursidae, Mustelidae and Procyonidae)? : Individual mitocondrial genes versus mitogenomics (Manuel Ruiz García, Departamento de Biología, Pontificia Universidad Javeriana, Spain) -- (6) Phylogeographic footprint of armadillo colonization in North America (María Clara Arteaga, Departamento de Biología de la Conservación, Mexico) -- (7) Koala conservation in Queensland: a role for a living genome bank in genetic rescue? (Jenny Seddon, School of Veterinary Science, The University of Queensland, Australia) -- (8) Noninvasive genetics sheds light on the status, phylogeography, and evolution of the most elusive carnivores: The case of the snow leopard (Jan Janecka, Department of Biological Sciences, Duquesne University, USA) -- (9) Documenting genetic diversity in changing populations for management and conservation (Jennifer Leonard, Conservation and Evolutionary Genetics, Estación Biológica de Doñana, Spain) -- (10) Conservation genetic of gray brocket deer (Mazama gouazoubira) in the southern of the distribution range (Susana González, Departamento de Biodiversidad y Genética, Universidad de Uruguay) -- (11) Noninvasive Genetic Monitoring of the Elusive European Wildcat as a Tool for Science-Based Wildlife Conservation (Katharina Steyer, Seckenberg Research Institute, Germany) -- (12) Conservation genetics in bats: current progress and future prospects (Serena Dool, University of Greifswald, Germany) -- (13) From dung to demography: Using noninvasive methods to study elephants inside and outside protected areas (Lori Eggert, Division of Biological Sciences, University of Missouri, USA) -- (14) Effect of the habitat connectivity in the genetic variability of the Volcano rabbit (Romerolagus diazi) (Jorge Ortega/Leslie Montes/José Antonio Guerrero, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional) -- (15) Different immune system diversity for city life: comparing major histocompatiblity complex alleles in San Joaquin kit fox (Vulpes macrotis mutica) (Jesus Maldonado/Tammy R Wilbert, Masoumeh Sikaroodi, Brian Cypher, Christine Van Horn Job, Katherine Ralls, and Patrick M. Gillevet, Center for Conservation Genomics, Smithsonian Institue, Washington, DC, USA) -- (16) Conclusion: current state and future prospects of conservation genomics in mammals (Jorge Ortega, Jesus Maldonado).
    Abstract: This book focuses on the use of molecular tools to study small populations of rare and endangered mammals, and presents case studies that apply an evolutionary framework to address innovative questions in the emerging field of mammalian conservation genomics using a highly diverse set of novel molecular tools. Novel and more precise molecular technologies now allow experts in the field of mammology to interpret data in a more contextual and empirical fashion and to better describe the evolutionary and ecological processes that are responsible for the patterns they observe. The book also demonstrates how recent advances in genetic/genomic technologies have been applied to assess the impact of environmental/anthropogenic changes on the health of small populations of mammals. It examines a range of issues in the field of mammalian conservation genomics, such as the role that the genetic diversity of the immune system plays in disease protection and local adaptation; the use of noninvasive techniques and genomic banks as a resource for monitoring and restoring populations; the structuring of population by physical barriers; and genetic diversity. Further, by integrating research from a variety of areas – including population genetics, molecular ecology, systematics, and evolutionary and conservation biology – it enables readers to gain a deeper understanding of the conservation biology of mammals that are at increasing risk of extinction at local, regional and global scales. As such, it offers a unique resource for a broad readership interested in the conservation biology of mammals and conservation management strategies to better preserve biodiversity.
    Type of Medium: Online Resource
    Pages: VII, 378 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030333348
    DDC: 333.9516
    Language: English
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  • 4
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XIII, 172 p. 32 illus., 31 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030364229
    Series Statement: Advances in Experimental Medicine and Biology, 1227
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Invertebrates. ; Biotechnology. ; Biomaterials. ; Invertebrate Zoology. ; Biotechnology. ; Biomaterials.
    Description / Table of Contents: 1. Polyphenols and flavonoids from honey: Biological applications -- 2. Chemistry and application of lac and its by-products -- 3. Silk: an amazing biomaterial for future medication -- 4. Insect Chitin and Chitosan: Structure, Properties, Production and Implementation Prospective -- 5. Recent advances in the arthropod natural product chemistry -- 6. Silkworm: A Unique Creature for Natural Products -- 7. Present and future prospects on nutritious feeding using insects -- 8. Insect Pheromones and its applications in management of pest population -- 9. Non-Protein chemical compounds from Lepidopteran insect cocoons. .
    Abstract: This book reviews the latest research on bioproducts from various economically important insects, such as silkworms, honey bees, lac and drosophila, and termites, and discusses their general, biomedical and industrial applications in detail. It includes chapters focusing on insects as a food source, probiotics, silk-based biomaterials, insect pheromones, insects as biomedicine source, pupa oil chemistry, non-protein compounds from Lepidopteran insects, insect chitin and chitosan, polyphenols and flavonoids. Model insects like Bombyx mori or bees were domesticated in Asian countries thousands of years ago. Over time, natural products from these animals became industrialized and today they attracting increasing attention thanks to their sustainability and their manifold applications in agriculture and biomedicine. The book is intended for entomologists, material scientists, natural product researchers and biotechnologists. .
    Type of Medium: Online Resource
    Pages: X, 156 p. 44 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030366100
    DDC: 592
    Language: English
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  • 6
    Keywords: Agriculture. ; Agriculture Economic aspects. ; Power resources. ; Food science. ; Sustainability. ; Agriculture. ; Agricultural Economics. ; Natural Resource and Energy Economics. ; Food Science. ; Sustainability.
    Description / Table of Contents: Chapter 1. Food systems in Sri Lanka: components, evolution, challenges and opportunities -- Chapter 2. Nutrition transition in Sri Lanka: a meta-analysis of the nutrition profile -- Chapter 3. Cascaded tank-village system: present status and prospects -- Chapter 4. Soil survey, classification and mapping in Sri Lanka – past, present and future -- Chapter 5. Milestones in the history of rice improvement in Sri Lanka -- Chapter 6. Vegetable breeding in Sri Lanka in retrospect -- Chapter 7. Genetic improvement for sustainability of coconut production: the Sri Lankan experience -- Chapter 8. Breaking the mould: pave the way for future cereals -- Chapter 9. Recent developments in vegetable production technologies in Sri Lanka -- Chapter 10. Input intensification in food crops production and food security -- Chapter 11. A cross section of century-long experiences in entomological research in crop sectors: directions for future research -- Chapter 12. Animal feed production in Sri Lanka: past present and future -- Chapter 13. Livestock and poultry to assure sustainability in the food system -- Chapter 14. Fisheries sector contribution for sustainable food system: past, present and future -- Chapter 15. Evolution of agricultural extension system in Sri Lanka -- Chapter 16. Performance and potential of agricultural insurance: global and Sri Lankan perspectives -- Chapter 17. Agricultural research for sustainable food systems – recommendations with special reference to Sri Lanka.
    Abstract: A food system comprises the entire range of actors and interlinked activities related to food production, processing, distribution, marketing and trade, preparation, consumption, and disposal. When a food system operates without compromising the needs of future generations, it is considered to be a “Sustainable Food System.” The present-day food systems in Sri Lanka are diverse, and the natural and physical environment, infrastructure, institutions, society and culture, and policies and regulations within which the food systems operate, as well as the technologies employed, have shaped their outcomes. Agricultural research is a key factor in terms of innovation and technological advances. Innovation has been the main driver of food systems’ transformation over the past few decades and will be critical to addressing the needs of a rapidly growing population in a context of climate change and scarcity of natural resources. In addition, agricultural research must help meet the rising demand for food at affordable prices. Comprising 17 chapters written by specialist(s) in their respective subject-areas, this Contributed Volume on “Agricultural Research for Sustainable Food Systems in Sri Lanka: A Historical Perspective” shares the scientific knowledge accumulated by the National Agricultural Research System of Sri Lanka, including universities, and offers recommendations on how to make food systems more sustainable in order to address the current needs of Sri Lankan society. It presents perspectives on four key thematic areas, namely: (i) Crop and animal production, management, and improvement, (ii) Agro-product processing technologies, (iii) Natural resource management, and (iv) Socio-economic development and agri-business management.
    Type of Medium: Online Resource
    Pages: XIX, 394 p. 63 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811521522
    DDC: 630
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Anatomy. ; Internal medicine. ; Cytology. ; Biochemistry. ; Neuroscience. ; Anatomy. ; Internal Medicine. ; Cell Biology. ; Biochemistry.
    Description / Table of Contents: Neurosecretion: A Historical Overview -- Neurosecretion: Hypothalamic Somata versus Neurohypophysial Terminals -- Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus -- Somato-Dendritic Secretion of Neuropeptides -- Neurosecretory Vesicles: Structure, Distribution, Release and Breakdown -- Molecular Controls on Regulated Neurotransmitter and Neurohormone Secretion -- Secretory Astrocytes -- Action Potential-Induced Ca2+ Influx for Both Acute and Sustained Insulin Secretion in Pancreatic Beta Cells -- Plasticity in the Morphology of Lactotrophs and Folliculo-Stellate Cells and Prolactin Secretion -- Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles -- Role of the TWIK-Related Potassium (TREK)-1 Channels in the Regulation of Adrenocorticotropic Hormone (ACTH) Secretion from Pituitary Corticotropes -- How Do Bacterial Neurotoxins Affect Neurosecretion? -- Secretory Mechanisms in Paramecium.
    Abstract: How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state‐dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley.
    Type of Medium: Online Resource
    Pages: XIII, 307 p. 65 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030229894
    Series Statement: Masterclass in Neuroendocrinology, 8
    DDC: 612.8
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Microbial genetics. ; Evolution (Biology). ; Population genetics. ; Microbial ecology. ; Medical genetics. ; Genetics. ; Microbial Genetics. ; Evolutionary Biology. ; Population Genetics. ; Microbial Ecology. ; Medical Genetics. ; Genetics and Genomics.
    Description / Table of Contents: Part 1: Genomic diversity and the pan-genome concept -- Chapter 1: The pan-genome: a data-drivendiscovery in biology -- Chapter 2: The prokaryotic species concept and challenges -- Chapter 3: Bacterial guide on how to design a diversified gene portfolio -- Chapter 4: A review of pan-genome tools and recent studies -- Part 2: Evolutionary biology of pan-genomes -- Chapter 5: Structure and dynamics of bacterial populations: pan-genome ecology -- Chapter 6: Bacterial microevolution and the pan-genome -- Chapter 7: Pan-genomes and selection: the public goods hypothesis -- Chapter 8: A pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance -- Part 3: Pan-genomics: an open, evolving discipline -- Chapter 9: Metapangenome: at the crossroad of pangenomics and metagenomics -- Chapter 10: Pan-genome flux balance analysis towards pan-phenomes -- Chapter 11: Bacterial epigenomics: epigenetics in the age of population genomics -- Chapter 12: Eukaryotic pan-genomes -- Chapter 13: Computational strategies for eukaryotic pan-genome analyses.
    Abstract: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
    Type of Medium: Online Resource
    Pages: XIV, 307 p. 47 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030382810
    DDC: 579.135
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture.
    Description / Table of Contents: Citrus origin, diffusion and economic importance -- Genetic resources of Citrus and related genera -- Conventional breeding of cultivated varieties -- Conventional breeding of rootstocks -- Ploidy manipulation as breeding strategy -- Markers, maps and marker-assisted selection -- From the draft genome of sweet orange toward a pan-genome -- New Breeding Techniques for Citrus -- From flower to fruit in citrus -- Genetic control of ripening -- Pigments in citrus: importance and genetic background -- Essential oils in citrus -- Abiotic stress resistance -- Biotechnological approaches for the resistance to citrus huanglongbling -- Genetic basis of canker resistance -- Molecular mechanisms for resistance to biotic stresses -- Future perspectives.
    Abstract: This book reviews how the release of the citrus genome facilitates the investigation of ancestral species, the study of their complex biological features, and the genetic basis of agronomic traits of paramount importance for their sustainable cultivation. The first chapters discuss citrus origin and distribution, and the economic importance and varietal composition of the cultivated species, providing an overview of citrus and related genera genetic resources. The book then describes the role of traditional breeding techniques (for scion and rootstocks) as well as the potential of genomic breeding and innovative protocols for biotechnological approaches. The second part provides essential information on the genus Citrus, the attributes of pure citrus species, genetic admixtures, hybrids and citrus relatives, and on the horticultural classification of cultivated species, varieties and rootstocks. The third part then focuses on the different molecular mechanisms, covering various aspects of citrus biology, including the role of beneficial compounds of citrus fruits. In addition, it examines the molecular responses of citrus to abiotic stresses and to field and post-harvest diseases. Providing insights gained in recent years, it is a valuable guide for those who are interested in gene discovery, comparative genomics, molecular breeding and new breeding techniques. It is particularly useful for scientists, breeders and students at universities and public sector institutes involved in research for the citrus industry.
    Type of Medium: Online Resource
    Pages: XIV, 294 p. 33 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030153083
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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  • 10
    Keywords: Medical microbiology. ; Industrial microbiology. ; Plant genetics. ; Pharmacology. ; Microbial genetics. ; Medical Microbiology. ; Industrial Microbiology. ; Plant Genetics. ; Pharmacology. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. The Artemisia genus: Panacea to Several Maladies -- Chapter 2. Bacopa monnieri: the Neuroprotective Elixir from the East: Phytochemistry, Pharmacology and Biotechnological Improvement -- Chapter 3. Current knowledge of Cinnamomum species: a review on the bioactive components, pharmacological properties, analytical and biotechnological studies -- Chapter 4. Swertia spp. : A potential source of high-value bioactive components, Pharmacology and Analytical techniques -- Chapter 5. The Genus Calophyllum: Review of Ethnomedicinal uses, Phytochemistry and Pharmacology -- Chapter 6. Plant Derived Quinones as a Source of Antibacterial and Anticancer Agents -- Chapter 7. Drugging protein-protein interaction interface with natural products: a computational approach -- Chapter 8. CQDs derived from natural sources: Excellent bio-imaging agents -- Chapter 9. Microbial Natural products: Recent insights into novel applications -- Chapter 10. Bioactive peptides and carbohydrates from natural products: a source of functional foods and nutraceuticals -- Chapter 11. Metabolites of fluorescent pseudomonads and their antimicrobial and anticancer potentials -- Chapter 12. Medicinal fungi: A natural source of pharmacologically important metabolites -- Chapter 13. Ganoderma: A propitious medicinal poroid mushroom -- Chapter 14. Pharmaceutically important metabolites from marine Fungi -- Chapter 15. Endophytic fungi: a trove of novel bioactive compounds -- Chapter 16. Novel Products from Microalgae -- Chapter 17. Lactic Acid Production and its Application in pharmaceuticals -- Chapter 18. Microbial Clot Busters: an Overview of Source, Production, Properties and Fibrinolytic Activity -- Chapter 19. Carbohydrate biopolymers: Diversity, applications and challenges -- Chapter 20. Biotechnological aspects of nanoparticles driven from natural products for drug delivery system and other applications -- Chapter 21. Methods and Techniques for the Chemical Profiling and Quality Control of Natural Products and Natural Product Driven Drugs -- Chapter 22. Characterization of Bioactive Secondary Metabolites of Fungal Endophytes -- Chapter 23. Modulation of Cellular Protein Quality Control Pathways Using Small Natural Molecules -- Chapter 24. Elaborating on the potential for mushroom-based products market expansion: Consumers’ attitudes and purchasing intentions -- Chapter 25. The Role of Algae in Nutraceutical and Pharmaceutical Production -- Chapter 26. Microbial interventions to induce secondary metabolites biosynthesis in medicinal and aromatic plants -- Chapter 27. Peptaibols: Antimicrobial peptides from Fungi.
    Abstract: This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.
    Type of Medium: Online Resource
    Pages: XII, 733 p. 96 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811513947
    DDC: 616.9041
    Language: English
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  • 11
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Description / Table of Contents: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Abstract: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Type of Medium: Online Resource
    Pages: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811525179
    Series Statement: Advances in Experimental Medicine and Biology, 1177
    DDC: 615
    Language: English
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  • 12
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Animal culture. ; Physiology. ; Biochemistry. ; Conservation biology. ; Ecology . ; Embryology. ; Animal Science. ; Animal Physiology. ; Chemical Biology. ; Conservation Biology. ; Embryology.
    Description / Table of Contents: Chapter 1: Reproductive physiology in fishes -- Chapter 2: Endocrine regulation of reproduction with special emphasis on gametogenesis in fishes -- Chapter 3: Factors influencing milt quality in fishes and its usefulness to cryopreservation -- Chapter 4: Energetics of fish spermatozoa -- Chapter 5: Fish sperm quality evaluation after cryopreservation -- Chapter 6: Cryopreservation – History and Development -- Chapter 7: Cryopreservation of fish gametes- an overview -- Chapter 8: Cryopreservation and short duration storage of germ cells and male gametes of freshwater fishes -- Chapter 9: Cryopreservation of marine fish sperm -- Chapter 10: Sperm cryopreservation in crustaceans -- Chapter 11: State of the art in cryopreservation of bivalve spermatozoa -- Chapter 12: Cryopreservation of germ stem cells in fishes -- Chapter 13: Cryopreservation and storage of oocytes, embryos and embryonic cells of fish -- Chapter 14: Potential of fish gamete cryopreservation in conservation programs in Bangladesh -- Chapter 15: Gamete manipulation and conservation for genetic improvement in penaeid shrimp.
    Abstract: Understanding the reproductive physiology and endocrinology of fishes is essential for captive maturation and seed production in the field of aquaculture. Studying the spermatology of fishes is a comparatively new focus in aquaculture, which has emerged as an important area of fish research over the past two decades. In this regard, the cryopreservation of fish gametes is a crucial aspect. Moreover, energetics studies of gametes have become essential, considering the loss of vigour in the spermatozoa after cryopreservation. The latest development in this context is the cryopreservation of spermatogonial stem cell, which is also covered in the book, along with detailed information on embryo cryopreservation in fishes and crustaceans. The role of cryopreservation in conservation programmes is another important aspect, one that will especially interest biologists. This book addresses central issues in fish gamete cryopreservation and breeding, while also reviewing the history of cryopreservation. Its most unique feature is the breadth of its coverage, from basic information on reproduction in fishes, to such advanced topics as embryo cryopreservation. Chiefly intended as a handy troubleshooting guide, the book represents a valuable resource for research students in related fields.
    Type of Medium: Online Resource
    Pages: IX, 352 p. 54 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811540257
    DDC: 636
    Language: English
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  • 13
    Keywords: Biotechnology. ; Plant diseases. ; Microbial ecology. ; Bacteria. ; Biology Technique. ; Biotechnology. ; Plant Pathology. ; Microbial Ecology. ; Bacteria. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Hairy Roots Biotechnology Unzipped: A Journey of Reality and Promises -- Chapter 2. Hairy Roots as a Source of Tropane Alkaloids -- Chapter 3. Induction, Metabolite Analysis and Transgenesis of Hairy Roots From Coleus Forskohlii -- Chapter 4. Establishment of Hairy Roots of Endangered Himalayan Plantswertiachirata: A Sustainable Alternative to Extraction from Nature -- Chapter 5. A Protocol for the Selection of Spontaneous Variants From Established Catharanthusroseus Hairy Root Cultures -- Chapter 6. Strategies for the Optimization of Culture Conditions for Increasing Metabolite Production Through Hairy Root Cultures. Monoterpenoid Indole Alkaloid Production in Catharanthus Roseus Hairy Roots -- Chapter 7. Protocol for Enhanced Withaferin-a Production in Elicited Withania Somnifera (l.)Dunal Hairy Root Cultures -- Chapter 8. Establishment of Hairy Root Cultures of Pentalinonandrieuxii for the Production of Betulinic Acid -- Chapter 9. Tropane Alkaloid Production by the Establishment Of Hairy Root Cultures of Brugmansia Candida and Elicitation -- Chapter 10. Elicitation as an Essential Strategy For Enhancing Anthraquinone Accumulation In Hairy Root Cultures of Rubia Tinctorum -- Chapter 11. Establishment of Hairy Root Cultures for the Production of Biopharmaceuticals and Optimization of Methods for Recombinant Protein Secretion In The Culture Medium -- Chapter 12. An Improved Protocol for Agrobacterium Rhizogenes-Mediated Transformation of Recalcitrant Plants for Root Biology Studies: A Case Study of Tea Plants (Camellia Sinensis Var. Sinensis) -- Chapter 13 Functional Analysis of Plant Genes Related to Arbuscular Mycorrhiza Symbiosis Using Agrobacterium Rhizogenes-Mediated Root Transformation and Hairy Root Production -- Chapter 14. Functional Characterization of Genes Involved in Legume Nodulation Using Hairy Root Cultures -- Chapter 15. Fluidigm Biomark Diagnostic Panel for Analysis of the Expression of Nicotiana Tabacum Genes, Associated with Alkaloid Synthesis. .
    Abstract: The book discusses the various methods and protocols available in hairy root culture-based research. The utilization of Agrobacterium mediated genetic transformation and establishment of hairy root cultures has paved the way for large-scale secondary metabolite production in medicinal plants. Presenting recent research and offering insights from eminent research groups, the book covers a range of topics related to hairy root-based applications, including (i) establishment of hairy roots and native production of SM (ii) yield enhancement strategies for increased SM production, like elicitation (iii) hairy roots as a tool for value-added applications such as plant-microbe interaction, characterization of plant genes and root biology studies. As such it is an informative guide and experimental manual for researchers in diverse fields of plant biology.
    Type of Medium: Online Resource
    Pages: XIV, 237 p. 47 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811540554
    Series Statement: Rhizosphere Biology,
    DDC: 660.6
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Surfaces (Physics). ; System theory. ; Zoology. ; Botany. ; Biology Technique. ; Computational and Systems Biology. ; Surface and Interface and Thin Film. ; Complex Systems. ; Zoology. ; Plant Science. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Various methods of pattern formation -- Chapter 3. Clusterization of biological structures with high aspect ratio -- Chapter 4. Contact between biological attachment devices and rough -- Chapter 5. Anisotropic friction in biological systems -- Chapter 6. Mechanical interlocking of biological fasteners -- Chapter 7. Biomechanics at the microscale -- Chapter 8. Nanoscale pattern formation in biological surfaces -- Chapter 9. Ecology and evolution.
    Abstract: Basic laws of nature are rather simple, but observed biological structures and their dynamic behaviors are unbelievably complicated. This book is devoted to a study of this “strange” relationship by applying mathematical modeling to various structures and phenomena in biology, such as surface patterns, bioadhesion, locomotion, predator-prey behavior, seed dispersal, etc. and revealing a kind of self-organization in these phenomena. In spite of diversity of biological systems considered, two main questions are (1) what does self-organization in biology mean mathematically and (2) how one can apply this knowledge to generate new knowledge about behavior of particular biological system? We believe that this kind of “biomimetics” in computer will lead to better understanding of biological phenomena and possibly towards development of technical implications based on our modeling.
    Type of Medium: Online Resource
    Pages: XVIII, 317 p. 151 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030415280
    Series Statement: Biologically-Inspired Systems, 16
    DDC: 570.285
    Language: English
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  • 15
    Keywords: Invertebrates. ; Invertebrate Zoology.
    Description / Table of Contents: 1. Agriculture and Impact of Invasive Species to Productivity in Africa -- 2. Bioassay-Guided Isolation of Active Phytochemicals Against Tuta Absoluta (Meyrick) from Turraea Floribunda and Caesalpinia Welwitschiana -- 3. Tuta Absoluta (Meyrick): Seasonal Abundance and Susceptibility of some Tomato Genotypes in Gezira State, Sudan -- 4. Evaluation of Resistance and Toxicity of different Insecticides on Tuta absoluta Meyrick Populations in Major Tomato Growing States of Nigeria -- 5. The First Effort at Adopting Integrated Pest Management IPM to Contain the Infestation of the Tuta Absoluta in Nigeria -- 6. New Record of Tuta Absoluta on Cowpea Vigna Unguiculata, Gezira State, Sudan -- 7. Efficacy of a Sudanese Strain of Entomopathogenic Fungus, Metarhizium Anisopliae Met. Sorokin on Puparia of Bactrocera Dorsalis Hendel, under Laboratory Conditions -- 8. Taxonomic keys to Economic Fruit Flies (Diptera: Tephritidae) of the Sudan -- 9. Injury and Yield Losses due to the Maize Stem Borer Busseola Fusca (Fuller) (Lepidoptera: Noctuidae) on Smallholder farms. -- 10. Establishment of an Exotic Parasitoid Cotesia vestalis in Coastal Areas of Kenya as Biological Control Agent of Plutella Xylostella -- 11. Enhancing Monitoring Efficiency and Management of Vectors of Maize Lethal Necrosis Disease in Kenya -- 12. Outbreak of fall Armyworm (Spodoptera Frugiperda) and its Impact in Rwanda Agriculture Production -- 13. Farmers’ Perceptions and Preferences on Pesticide use in the Management of Fall armyworm in Rwanda -- 14. Chronological Review of Fruit Fly Research and Management Practices in Sudan -- 15. Integrated Pest Management for Control the Date Palm Green Pit Scale Insect Palmapsis Phoenicis Ra (Homoptera: Asterolecaniidae) in Sudan -- 16. Use of Para-Pheromone Methyl Eugenol for Suppression of the Mango Fruit Fly, Bactrocera Dorsalis (Hendel) (Diptera:Tephritidae) in Southern Ethiopia -- 17. Sudan Thematic Implementation Plan for the Management of Invasive Red Palm Weevil (RPW), Rhynchophorus Ferrugineus (Olivier) -- 18. Management of Pests of Quarantine Importance in Ghana’s Export Vegetables (Chili, Eggplant and Ridged Gourds) -- 19. The Role of Plantwise in Improving Detection and Action on Pest Situations -- 20. Semiochemical-Baited Autodissemination Device for Managing BFT on Cowpea -- 21. Influence of Predatory Mites, Phytoseiulus Longipes Evans. on the Within-Plant Diurnal Migration and Distribution of the Red Spider Mite, Tetranychus Evansi, Baker and Pritchard on African Nightshade, Solanum Scabrum -- 22. Effects and Persistence of Endophytic Beauveria Bassiana in Tomato Varieties on Mite Density Tetranychus Evansi in the Screenhouse -- 23. Flight Behaviour and Activity Time of Tuta absoluta (Meyrick) Males Trapped on Tomato and Miscellaneous Crops, Gezira State, Sudan.
    Abstract: Invasive species, generally, affect economically important crops, thus affecting the livelihoods of millions of people along crop value chains. Typically, invasive species have high migratory capabilities and, because of plant material exchanges made during trade, they cannot be contained by one country. Usually, African countries react after a pest has invaded and established itself in the country, making the cost of mitigating the pest even more expensive. This book presents a pan-African view of the impacts of invasive insect pests on agriculture and of how invasive species impact on productivity in Africa. It not only describes their importance, but also presents a diversity of research findings in the field, ranging from the use of early warning and monitoring systems for quarantine purposes, agricultural extension, all the way to control strategies. The IPM arsenal presented in this book includes the use of botanical bioactive compounds, semiochemicals, resistant varieties, biological control agents such as entomopathogens, endophytes, predators, and natural enemies. Aspects of technology transfer strategies, regional coordination, and farmers’ perceptions have not been overlooked, because these affect the adoption of mitigation strategies. The book also presents measures that would help agricultural research services to estimate the damage and take actions for preparedness and readiness to face invasive insect pests. This starts with a basic knowledge of taxonomy to enable concerned persons to describe the insects and the vast inventory of affected crops. Physiological and ecological aspects of invasive pests are strongly highlighted to strengthen Integrated Pest Management Strategies. The threat of invasive species will remain permanent; therefore, the book encourages knowledge exchange and collaboration between researchers and scientists on the continent, while encouraging the establishment of a platform or a fund for preparedness and rapid response.
    Type of Medium: Online Resource
    Pages: XXVI, 303 p. 64 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030410834
    Series Statement: Sustainability in Plant and Crop Protection, 14
    DDC: 592
    Language: English
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  • 16
    Keywords: Evolution (Biology). ; Astrobiology. ; Planetary science. ; Evolutionary Biology. ; Astrobiology. ; Planetary Science.
    Description / Table of Contents: Preface -- Chapter 1. What is astrobiology? -- Chapter 2. Astrobiology and Planetary Sciences in Mexico -- Chapter 3. Was LUCA a Hyperthermophilic Prokaryote? The Impact-Bottleneck Hypothesis Revisited -- Chapter 4. Stromatolites, Biosignatures, and Astrobiological Implications -- Chapter 5. The global distribution of modern microbialites: not so uncommon after all -- Chapter 6. The importance of the rare biosphere for astrobiological studies and the diversification and resilience of life on Earth -- Chapter 7. Bacterial communities from deep-hydrothermal systems: the southern Gulf of California as an example of primeval environments -- Chapter 8. Andean Microbial Ecosystems: traces in hypersaline lakes about life origin -- Chapter 9. Stromatolites in crater-lake Alchichica and Bacalar lagoon -- Chapter 10. The origin and early evolution of life on Earth: A laboratory in the School of Science -- Chapter 11. Cuatro Ciénegas as an Archaean Astrobiology Park -- Index.
    Abstract: Astrobiology not only investigates how early life took hold of our planet but also life on other planets – both in our Solar System and beyond – and their potential for habitability. The book take readers from the scars on planetary surfaces made by space rocks to the history of the Solar System narrated by those space rocks as well as exoplanets in other planetary systems. But the true question is how life arose here or elsewhere. Modern comparative genomics has revealed that Darwin was correct; a set of highly conserved genes and cellular functions indicate that all life is related by common ancestry. The Last Universal Common Ancestor or LUCA sits at the base of the Tree of Life. However, once that life took hold, it started to diversify and form complex microbial communities that are known as microbial mats and stromatolites. Due to their long evolutionary history and abundance on modern Earth, research on the biological, chemical and geological processes of stromatolite formation has provided important insights into the field of astrobiology. Many of these microbialite-containing ecosystems have been used as models for astrobiology, and NASA mission analogs including Shark Bay, Pavilion and Kelly Lakes. Modern microbialites represent natural laboratories to study primordial ecosystems and provide proxies for how life could evolve on other planets. However, few viral metagenomic studies (i.e., viromes) have been conducted in microbialites, which are not only an important part of the community but also mirror its biodiversity. This book focuses on particularly interesting sites such as Andean lake microbialites, a proxy of early life since they are characterized by very high UV light, while Alchichica and Bacalar lakes are characterized by high-salt and oligotrophic waters that nurture stromatolites. However, it is only the oasis of Cuatro Ciénegas Basin in México that stored past life in its marine sediments of the Sierra de San Marcos. This particular Sierra has a magmatic pouch that moves the deep aquifer to the surface in a cycle of sun drenched life and back to the depths of the magmatic life in an ancient cycle that now is broken by the overexploitation of the surface water as well as the deep aquifer in order to irrigate alfalfa in the desert. The anthropocene, the era of human folly, is killing this unique time machine and with it the memory of the planet.
    Type of Medium: Online Resource
    Pages: VIII, 232 p. 41 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030460877
    Series Statement: Cuatro Ciénegas Basin: An Endangered Hyperdiverse Oasis,
    DDC: 576.8
    Language: English
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  • 17
    Keywords: Agriculture. ; Microtechnology. ; Microelectromechanical systems. ; Environmental chemistry. ; Nanochemistry. ; Environmental policy. ; Agriculture. ; Microsystems and MEMS. ; Environmental Chemistry. ; Nanochemistry. ; Environmental Policy.
    Description / Table of Contents: Chapter 1 - State of the art of the development of nanopesticides and their potential benefits -- Chapter 2 - Understanding the interaction of nanopesticides with plants -- Chapter 3 - Study of the interaction of nanopesticides with soil microbiota -- Chapter 4 - Methods for understanding the interaction of nanopesticides with soil and water -- Chapter 5 - State of the art in ecotoxicological assays to study the effects of nanopesticides against non-target organisms -- Chapter 6 - Nanoherbicides -- Chapter 7 - Nanoinsecticides -- Chapter 8 - Nanofungicides -- Chapter 9 - Alternative models for initial screening of nanopesticides safety -- Chapter 10 - Methods for the evaluation toxicological effects of nanopesticides in humans -- Chapter 11 - Use of DNA/RNA and nanotechnology aiming pest control -- Chapter 12 - Regulatory issues regarding Nanopesticides Chapter 13 - Nanopesticides: from the bench to the market -- Chapter 14 - Nanopesticides: risk analysis.
    Abstract: This book explores the development of nanopesticides and tests of their biological activity against target organisms. It also covers the effects of nanopesticides in the aquatic and terrestrial environments, along with related subjects including fate, behaviour, mechanisms of action and toxicity. Moreover, the book discusses the potential risks of nanopesticides for non-target organisms, as well as regulatory issues and future perspectives.
    Type of Medium: Online Resource
    Pages: XXI, 360 p. 56 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030448738
    DDC: 630
    Language: English
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  • 18
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.
    Abstract: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
    Type of Medium: Online Resource
    Pages: VIII, 538 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504946
    Series Statement: Handbook of Experimental Pharmacology, 261
    DDC: 615
    Language: English
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  • 19
    Keywords: Evolution (Biology). ; Plant genetics. ; Genetics. ; Microbial genetics. ; Evolutionary Theory. ; Plant Genetics. ; Genetics and Genomics. ; Microbial Genetics.
    Abstract: This book presents a comprehensive overview of DNA barcoding and molecular phylogeny, along with a number of case studies. It discusses a number of areas where DNA barcoding can be applied, such as clinical microbiology, especially in relation to infection management; DNA database management; and plant -animal interactions, and also presents valuable information on the DNA barcoding and molecular phylogeny of microbes, algae, elasmobranchs, fishes, birds and ruminant mammals. Furthermore it features unique case studies describing DNA barcoding of reptiles dwelling in Saudi Arabian deserts, genetic variation studies in both wild and hatchery populations of Anabas testudineus, DNA barcoding and molecular phylogeny of Ichthyoplankton and juvenile fishes of Kuantan River in Malaysia, and barcoding and molecular phylogenetic analysis of indigenous bacteria from fishes dwelling in a tropical tidal river. Moreover, since prompt identification and management of invasive species is vital to prevent economic and ecological loss, the book includes a chapter on DNA barcoding of invasive species. Given its scope, this book will appeal not only to researchers, teachers and students around the globe, but also to general readers.
    Type of Medium: Online Resource
    Pages: VI, 267 p. 41 illus., 23 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030500757
    DDC: 576.801
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Botany. ; Agriculture. ; Plant physiology. ; Plant Science. ; Agriculture. ; Plant Physiology.
    Description / Table of Contents: Chapter 1. Introduction to MAPs in the North America -- Chapter 2. Dr. Duke's Phytochemical and Ethnobotanical databases, a cornerstone in the validation of ethnoveterinary medicinal plants, as demonstrated by data on pets in British Columbia -- Chapter 3. Pharmacopoeial Wild Medicinal Plants of North America -- Chapter 4. Medicinal Plant Products, a Discussion of Actual or Probable versus Perceived Sources -- Chapter 5. Juniper species in North America to the same species in Europe with respect to phytochemistry and bioactivity -- Chapter 6. Mentha Genetic Diversity at the US National Clonal Germplasm Repository in Corvallis, Oregon -- Chapter 7. Advances in the research of basil -- Chapter 8. Advances in ther research of catnip -- Chapter 9. Diversity, conservation and sustainable harvest of medicinal plants in North America -- Chapter 10. The Great botanist, Jim Duke -- Chapter 11. TBC -- Chapter 12. Taxol or the story of the American yew -- Chapter 13. The Indian Tobacco -- Chapter 14. The American Elderberry -- Chapter 15. The American Ginseng.
    Abstract: This volume is aimed at offering an insight into the present knowledge of the vast domain of Medicinal and Aromatic Plants with a focus on North America. In this era of global climate change the volume is meant to provide an important contribution to a better understanding of the diverse world of Medicinal and Aromatic Plant research, production and utilization.
    Type of Medium: Online Resource
    Pages: VIII, 342 p. 59 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030449308
    Series Statement: Medicinal and Aromatic Plants of the World, 6
    DDC: 580
    Language: English
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  • 21
    Keywords: Invertebrates. ; Applied ecology. ; Biodiversity. ; Microbial ecology. ; Conservation biology. ; Ecology . ; Forestry. ; Invertebrate Zoology. ; Applied Ecology. ; Biodiversity. ; Microbial Ecology. ; Conservation Biology. ; Forestry.
    Description / Table of Contents: 1. Preface -- 2. Improving the efficacy of biological control by ecostacking -- 3. Integrative biological control approaches in Chinese agriculture, Biodiversity enhancement for improving biological control -- 4. Perennial wildflower strips to enhance natural enemies of insect pests in Belgium -- 5. Flower strips for ecosytem services in Switzerland, Felix Herzog, Agroscope, Zurich Switzerland -- 6. Enhancement of natural control functioning of rice insect pests by manipulating biodiversity in rice-based ecosystems -- 7. Cover crops enhance biological control of insect pests in apple orchards in China -- 8. Enhancement of natural control function in aphids by intercropping and infochemical releasers in wheat ecosystem -- 9. Crop diversity and disease control,Specific techniques to enhance ecostacking -- 10. Ecological enhancement of arthropod natural enemy application in biological control -- 11. Chemical ecology of egg parasitoids in crop protection -- 12. Current knowledge on the migratory moth Autographa gamma as basis for future chemo-ecological research -- 13. The development of biocontrol products and their applications in the field -- 14. Effects of insecticides on pollen beetles (Brassicogethes aeneus) and their tersilochine parasitoids in Germany -- 15. How microbiome approaches can assist market development for biological control -- 16. Successful use of entomopathogenic nematodes to control a defoliator outbreak in an environmentally sensitive area -- 17. Bees and medicinal plants -- 18. Climate change implications -- 19. Night warming on predator-prey interactions: implications for biological control -- 20. Landscape-level drivers of biocontrol and case study from local to regional scale under climate change in China -- 21. Spotted Wing Drosophila-blueberry interactions.
    Abstract: This book is the first to integrate biological control into a conceptual framework – ecostacking - uniting all aspects of biological control and ecosystem services. In 2018 the "First International Congress of Biological Control" was organised and held in Beijing, China. The chapters highlight some of the achievements presented at the congress, worldwide. Of particular significance are the numerous contributions by Chinese researchers illustrating the remarkable progress made on developing and adopting multiple biological control strategies over vast agricultural areas, largely replacing chemical pesticides for sustainable agricultural and horticultural production. In many parts of the world including Europe, fragmented research based on short-term funding has been unable to answer to the needs to develop sustainable long-term solutions to crop protection, while colleagues in China have been successful in implementing programs that exemplify the power of the ecostacking approach. Key contributions by European and US specialists combined with the expertise and experiences by the Chinese contributors comprise the building blocks for the integration of biological control approaches into the overall frame of ecostacking. This book will lead the way to a broader, integrated adoption of biological control techniques in sustainable pest, disease and weed management supporting also the functioning of other key ecosystem services. Chapter 2 of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 248 p. 63 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030448387
    Series Statement: Progress in Biological Control, 20
    DDC: 592
    Language: English
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  • 22
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Neurology . ; Nervous system Radiography. ; Neuropsychology. ; Neurosurgery. ; Neurology. ; Neuroradiology. ; Neuropsychology.
    Description / Table of Contents: History of Epilepsy Surgery -- Epilepsy: Clinical, Epidemiological, and Therapeutical Aspects -- Presurgical Evaluation -- Surgical Tools and Techniques -- Anesthesia -- Temporal Lobe Resections -- Extratemporal Resections -- Hemispherical Procedures -- Long-Term Epilepsy-Associated Tumors (LEATs) -- MRI-Negative Epilepsies -- Pediatric Epilepsy Surgery -- Reoperations after failed surgery -- Pathology in Epilepsy Surgery -- Non-Resective Epilepsy Surgery -- Complications -- Cost-Effectiveness of Epilepsy Surgery -- The current Place of Epilepsy Surgery -- A personal view.
    Abstract: This book fills the gap between the increasing demand for epilepsy surgical experience and limited training facilities in this area. It comprehensively describes surgical techniques, including tricks and pitfalls, based on the author’s 30 years of experience, providing optimal and effective training for young neurosurgeons by avoiding learning by trial and error. Moreover, it also includes useful information for epileptologists and other professionals involved in the epilepsy surgical program to allow them to gain a better understanding of possibilities and limitations of epilepsy surgery. .
    Type of Medium: Online Resource
    Pages: XXI, 404 p. 154 illus., 111 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030487485
    DDC: 617.48
    Language: English
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  • 23
    Keywords: Conservation biology. ; Ecology . ; Environment. ; Biotechnology. ; Pollution. ; Earth sciences. ; Geography. ; Conservation Biology. ; Environmental Sciences. ; Biotechnology. ; Pollution. ; Earth and Environmental Sciences.
    Description / Table of Contents: Preface -- Concerns and Threats of Heavy Metals Contamination on Aquatic Ecosystem -- Pollution in Aquatic Environs: Sources and consequences -- A Recent Scenario of Groundwater Quality in Northwest Himalaya, India -- Polycyclic aromatic hydrocarbons: Toxic Effects and their Bioremediation Strategies -- Mechanisms and importance of phytoremediation -- Role of Soil Biota and Associated Threats -- Viability of in-situ and ex-situ bioremediation approaches for degradation of noxious substances in stressed environs -- Bioremediation: A viable approach for degradation of petroleum hydrocarbon -- Application of macrophytes for remediation of wastewater in constructed wetlands -- Application of Biotechnology for restoration of degraded environs -- Role of Free Floating Aquatic Macrophytes in abatement of the disturbed Environs -- Genetically Modified Microbes as Biofertilizers -- Nanotechnology: A Modern Waste management approach -- Restoration of Heavy Metal Contaminated Environs through Ectomycorrhizal Symbiosis -- Index.
    Abstract: The rapid thriving of industries, conversion of agricultural land to residential areas, habitat destruction, deforestation and use of recalcitrant synthetic substances enhanced the rate of degradation of the environment. Although there are various conventional techniques for degradation and cleaning of noxious pollutants from disturbed environs, they are energy inefficient and costly to install. Bioremediation has emerged recently as an alternative and novel approach to manage and control environmental pollutants. This volume focuses explicitly on the remediation of noxious substances in stressed environs. It includes expert-contributed chapters on bio-monitoring by way of evaluating the relationship of biota with the polluted/stressed environs, sustainable plant-based degradation of noxious pollutants, and the application of biotechnologies to achieve tailored responses. Academicians, researchers, scientists and students will find this work essential for sustainable treatment of noxious pollutants. This book also serves as a core guide for training, teaching and research in conservation biology and environmental rehabilitation.
    Type of Medium: Online Resource
    Pages: XX, 340 p. 41 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030486907
    DDC: 333.9516
    Language: English
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  • 24
    Keywords: Biodiversity. ; Agriculture. ; Forestry. ; Plant biotechnology. ; Plant diseases. ; Energy policy. ; Energy and state. ; Biodiversity. ; Agriculture. ; Forestry. ; Plant Biotechnology. ; Plant Pathology. ; Energy Policy, Economics and Management.
    Description / Table of Contents: Genetically modified organisms (GMOs) impact and current status in Latin America: technological sovereignty or dependence? -- New biotechnology promising approaches for disease control on bananas and plantains -- Complementation of bananas conventional breeding programs through biotechnological genetic improvement -- The stress as inducer of heritable changes in micropropagated banana: the hypothesis of cytokinin accumulation -- Somatic embryogenesis for clonal propagation and associated molecular studies in cacao (Theobroma cacao L.) -- Use of biotechnology in Forestry breeding programs for natural resources and biodiversity conservation; Creating super trees for the future -- Stress modulation in Pinus spp. Somatic embryogenesis as model for climate change mitigation; Stress is not always a problem -- A Protective Role for Accumulated Dry Matter Reserves in Seeds During Desiccation: Implications for Conservation -- Biodiversity in Ecuador and its immense potential for agricultural pest control -- Native biodiversity: a strategic resource to accelerate bioeconomy development in Latin America and the Caribbean -- Low cost crop waste biosorbent technology for removing toxic and pollutants from wastewater -- The status of plant and plant-microbe interactions related to medicinal agents -- Bringing new function to packaging materials by agricultural byproducts -- Use of banana crop wastes to develop products in the aquaculture and plastic sectors -- Use of agroindustrial biomass for biofuels, enzymes discovery and production -- Temperature Profiles during the Fermentation of Cacao ‘Nacional’ to understand chocolate quality -- Ethno Phytopharmacology. Product validation process based on traditional knowledge of medicinal plants -- Biological control as a key tool for the management of invasive species in Latin America and the Caribbean -- Current research on Andean fruit crop diseases -- Biotechnological tools for the development of Foc TR4-resistant or tolerant Musa spp. Cultivars -- Integrated pest management of whitefly crop-free periods can reduce the Begomovirus transmission in tomato.
    Abstract: Food security, crop protection, biodiversity, and human and environmental health are among the main needs and concerns of society. Modern biotechnology and life sciences represent a constantly evolving area that is key for the rational use of natural resources – resources that in turn are indispensable for societal development. This book features the outcomes of the IV International Biotechnology and Biodiversity Congress, held in Guayaquil, Ecuador, 2018. It includes extensive reviews of the trends in agricultural and forestry biotechnology, molecules and materials biodiscovery, ethnomedicine, environmental impact and bioindustry research, describing many of these topics from the Latin America perspective and showing how the biodiversity and ancient knowledge of these countries are vital for worldwide sustainable development. .
    Type of Medium: Online Resource
    Pages: XIX, 460 p. 82 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030513580
    DDC: 333.95
    Language: English
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  • 25
    Keywords: Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Description / Table of Contents: Ch 1: Listening to All Voices: Interdisciplinary Approaches to Understanding Hearing in Aging -- Ch 2: Genetic and Molecular Aspects of the Aging Auditory System -- Ch 3: The Aging Cochlea and Auditory Nerve -- Ch 4: Age-Related Changes in the Auditory Brainstem and Inferior Colliculus -- Ch 5: Age related changes in the primate auditory cortex -- Ch 6: The Aging Auditory System: Electrophysiology -- Ch 7: Age-Related Changes in Segregation of Sound Sources -- Ch 8: Causes and Consequences of Age-Related Hearing Loss -- Ch 9: Age-Related Changes in Speech Understanding: Peripheral versus Cognitive Influences -- Ch 10: Aging, Hearing Loss, and Listening Effort: Imaging Studies of the Aging Listener -- Ch 11: Functional Consequences of Impaired Hearing in Older Adults and Implications for Intervention -- Ch 12: Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss.
    Abstract: This volume provides contemporary discussions on new developments in aging research. It serves as an important update on the current state of research on the aging auditory system. Listening to All Voices: Interdisciplinary Approaches to Understanding Hearing in Aging Karen S. Helfer and Edward L. Bartlett Genetic and Molecular Aspects of the Aging Auditory System Shinichi Someya and Mi-Jung Kim The Aging Cochlea and Auditory Nerve Kevin K. Ohlemiller and Christopher Spankovich Age-Related Changes in the Auditory Brainstem and Inferior Colliculus Josef Syka Age-Related Changes in the Primate Auditory Cortex Gregg Recanzone The Aging Auditory System: Electrophysiology Kelly C. Harris Age-Related Changes in Segregation of Sound Sources Frederick J. Gallun and Virginia Best Causes and Consequences of Age-Related Hearing Loss Jennifer A. Deal, Nicholas S. Reed, Emily C. Pedersen, and Frank R. Lin Age-Related Changes in Speech Understanding: Peripheral versus Cognitive Influences Sandra Gordon-Salant, Maureen J. Shader, and Arthur Wingfield Aging, Hearing Loss, and Listening Effort: Imaging Studies of the Aging Listener Stefanie E. Kuchinsky and Kenneth I. Vaden, Jr. Functional Consequences of Impaired Hearing in Older Adults and Implications for Intervention Larry E. Humes, M. Kathleen Pichora-Fuller, and Louise Hickson Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss Robert D. Frisina, Carlos J. Cruz, Tanika T. Williamson, Xiaoxia Zhu, and Bo Ding .
    Type of Medium: Online Resource
    Pages: XVII, 323 p. 62 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030493677
    Series Statement: Springer Handbook of Auditory Research, 72
    DDC: 612.8
    Language: English
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  • 26
    Keywords: Paleoecology. ; Paleontology . ; Bioinformatics. ; Archaeology. ; Earth sciences. ; Paleoecology. ; Paleontology. ; Computational and Systems Biology. ; Archaeology. ; Earth Sciences.
    Description / Table of Contents: Chapter 1-Introduction -- Chapter 2-Historical perspective -- Chapter 3-Geology and stratigraphy -- Chapter 4-Indian late cretaceous dinosaur nesting sites -- Chapter 5-Discussion. Chapter -- 6-Summary and conclusions.
    Abstract: This book documents analyses of the Late Cretaceous dinosaur nesting sites of the Lameta Formation at Jabalpur, Districts Dhar and Jhabua, Madhya Pradesh; Districts Kheda and Panchmahal (Gujarat); and the Pisdura, Dongargaon and Pavna sectors in the Chandrapur Districts of Maharashtra, which are exposed in India along an east-west and central axis. In this work, special emphasis has been given to the dinosaur nesting sites of the east-central Narbada River region, including its regional geology. The work was undertaken to provide detailed information concerning dinosaur eggs, eggshell fragments, nests and clutches found in the Lameta Formation of peninsular India. Prior to the present work there had been no detailed review of systematic work on the taxonomy, and of micro- and ultrastructural studies of dinosaur eggs and eggshells from the Lameta Formation. The study documents the field and laboratory investigations that facilitated the reconstruction of the morphotaxonomy, models for the burial pattern of eggs and eggshells, taphonomic implications,and the palaeoenvironmental context and palaeoecological conditions during the Late Cretaceous at the time of the extrusion of the Deccan traps, which may have been partly responsible for the extinction of the dinosaurs. The need to follow a parataxonomic classification for Indian dinosaur eggs and eggshell types is very apparent, and this book addresses this aspect in some detail. The emphasis on the application of parataxonomic schemes is based on the description of new oospecies and their comparison with previously known forms. The present work has led to the recovery of numerous nests, many collapsed eggs and hundreds of dinosaur eggshell fragments from the localities situated near the east, west and central Narbada River regions. It will be of interest to academics and professional palaeontologists, and all students of dinosaurs.
    Type of Medium: Online Resource
    Pages: XX, 280 p. 92 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030564544
    Series Statement: Topics in Geobiology ; 51
    DDC: 560.45
    Language: English
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  • 27
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant diseases. ; Agriculture. ; Conservation biology. ; Ecology . ; Plant Pathology. ; Agriculture. ; Conservation Biology.
    Description / Table of Contents: I. Biology of Plant defence -- 1.Plant defense in biological pest control -- 2. Specialized metabolites and plant defence -- 3.Sources of variation in defensive traits in Quercus species -- 4.Glycans as Modulators of Plant Defense -- 5.Biological Control and Need of a Strategic Shift -- II. Use of natural compounds -- 6.Polyphenolic Compounds Obtained from OMWW -- 7.small molecules of natural origin -- 8.Pinus polyphenols and antifungal activities -- 9.stilbenoid-enriched grape cane extracts in biocontrol -- III. Use of biological agents -- 10.Biological control of postharvest diseases -- 11.Sorghum allelopathy for sustainable weed management -- 12.Chaetomium as biocontrol agent on plant pathogens -- 13.Fusaria strains as biocontrol agents -- 14. Fungi as biological control -parasitic nematodes -- 15.Control of pepper powdery mildew -- 16.Molecular Mechanisms of Nematode- Microbe Interactions -- VI. Market and commercialization -- 17.Trends for commercialization of Biocontrol Agent.
    Abstract: Insects, pests and weeds are responsible for substantial loss of crops and reduced food supplies, poorer quality of agricultural products, economic hardship for growers and processor. Generally, chemical control methods are neither always economical nor are they effective and may have associated unwanted health, safety and environmental risks. Biological control involves use of beneficial biological agents to control pests and offers an environmental friendly approach to the effective management of plant diseases and weeds. The chapters are written by well recognized group leaders in the field. This book provides a comprehensive account of interaction of host and pests, and development of biological control agents for practical applications in crops management utilizing inherent defence mechanism, induced stimulation and biological control agents. The contents are divided into the following sections: General biology of plant defence, Use of natural compounds for biological control, Use of biological agents, Mechanism of action and Commercial aspects. The book will be useful for academicians, researcher and industries involved in study and manufacturing these products.
    Type of Medium: Online Resource
    Pages: X, 478 p. 72 illus., 54 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030510343
    Series Statement: Progress in Biological Control, 22
    DDC: 571.92
    Language: English
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  • 28
    Keywords: Medical microbiology. ; Diseases. ; Microbiology. ; Medical Microbiology. ; Diseases. ; Microbiology.
    Description / Table of Contents: Chapter 1: The INFECT-project: An international multidisciplinary project on necrotizing soft tissue infections -- Chapter 2: Necrotizing Soft Tissue Infections: case reports from the patients prospective -- Chapter 3: Necrotizing soft tissue infections: Case-reports, from the clinician’s perspectives -- Chapter 4: Necrotizing soft tissue infections: clinical features and diagnostic aspects -- Chapter 5: Microbiological etiology of necrotizing soft tissue infections -- Chapter 6: Beta-hemolytic streptococci and necrotizing soft tissue infections -- Chapter 7: Treatment of necrotizing soft tissue infections: Antibiotics -- Chapter 8: Treatment of necrotizing soft tissue infections: IVIG -- Chapter 9: Pathogenic mechanisms of streptococcal necrotizing soft tissue infections -- Chapter 10: Systems genetics approaches in mouse models of Group A Streptococcal necrotizing soft tissue infections -- Chapter 11: Systems biology and biomarkers in necrotizing soft tissue infections -- Chapter 12: Systems and precision medicine in necrotizing soft tissue infections.
    Abstract: This volume aims to enhance the current understanding of clinical features, treatment and pathogenic aspects in necrotizing soft tissue infections. Various representative case studies are discussed to enhance the readers’ understanding of these complex diseases. Necrotizing soft tissue infections are rapidly spreading infections that may cause extensive soft tissue or limb loss, multiorgan failure and are associated with a considerable fatality rate. It is undisputed that rapid diagnosis and prompt intervention is directly related to survival. The initial presentation may be limited to unspecific symptoms such as tenderness, swelling, erythema and pain. Thus, diagnosis and management are challenging due to heterogeneity in clinical presentation, in co-morbidities, in microbiological aetiology, as well as in the pathogenic mechanisms. An international and multidisciplinary consortium, INFECT, has for the last 6 years been pursuing research aimed to advance the understanding of the clinical and pathogenic aspects of these infections. A central part has been to create a comprehensive clinical registry and associated biobank which have also formed the basis for the experimental studies. Using the INFECT patient cohort, as well as an integrated systems biology approach in patients and clinically relevant experimental models, an advanced insight of diagnostic features, causative microbial agents, treatment strategies, and pathogenic mechanisms (host and bacterial disease traits and their underlying interaction network) has been obtained.
    Type of Medium: Online Resource
    Pages: VIII, 207 p. 60 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030576165
    Series Statement: Advances in Experimental Medicine and Biology, 1294
    DDC: 616.9041
    Language: English
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  • 29
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biomaterials. ; Nucleic acids. ; Bioinformatics. ; Biology Technique. ; Nucleic Acid. ; Computational and Systems Biology. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Strategies in Life sciences -- Chapter 2. Management and Manufacturing process of biologics -- Chapter 3. Downstream processes -- Chapter 4. Bioprinting -- Chapter 5. Biopharmaceuticals: New Frontier.
    Abstract: Tailoring of biomolecules using protein engineering technology, and host cells culture techniques are among the most sophisticated and elegant achievements of modern applied life sciences in which the basic fundamentals biotechnology are applicable for the development and manufacturing of biologics and other related bio-molecules for a hurdle free life with good health. A majority of biologics derived from genetically modified host cells in the current market are bio-formulation such as antibodies, nucleic acid products and vaccines. Such bio-formulations are developed mainly in two steps i.e. upstream process and downstream process. The first volume of this series begins with the latest information on how the classical stepwise host cells culture (mammals, animals, plants, and bacteria) methodology has been changed to fully continuous or partially continuous host cells culture process in order to economise the biopharmaceutical products manufacturing process. In addition this volume narrates a brief history on conceptual development of new thoughts in designing biotechnology industries for commercial production of variety of therapeutic proteins with structural modification on the basis of clinical requirements. The readers will feel exited by going through the latest discovery and development in applied life sciences for designing innovative biomolecules for health care with utmost safe. The most interesting part of this volume is newly developed concept on bioprinting. It explains how to design and fabricate animate objects by fusing or depositing material of interest in the form of powders, solid dusts, metal, liquid or even living cells or tissues by layers to produce 3D objectives. The first volume ends with the latest information on the current trend in biologics market, market dynamic, drives, and opportunities with challenges.
    Type of Medium: Online Resource
    Pages: XV, 189 p. 84 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811575907
    Series Statement: New Paradigms of Living Systems, 1
    DDC: 620.19
    Language: English
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  • 30
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.
    Abstract: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 162 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030502249
    Series Statement: Advances in Experimental Medicine and Biology, 1277
    DDC: 571.978
    Language: English
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  • 31
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Atoms. ; Molecules. ; Biotechnology. ; Atomic, Molecular and Chemical Physics.
    Description / Table of Contents: Photonic crystals for biomolecule sensing applications -- Recent advances in Surface Plasmon Resonance for biosensing applications and future prospects -- Surface-enhanced Raman Scattering for biology and medicine -- Nanophotonic techniques for single cell analysis -- Biointerface Characterization by Nonlinear Optical Spectroscopy -- Chemiluminescence and its biomedical applications -- Luminescent Conjugated Polymer Dots for Biomedical Applications -- Dark-Field Hyperspectral Imaging (DF-HSI) Modalities for Characterization of Single Molecule and Cellular Processes -- Additive Manufacturing Technologies based on Photopolymerization.
    Abstract: This book summarizes the latest advances in nanophotonics for biomedical applications, including biomolecular sensing and imaging, additive fabrications, and biophotonics. The engineering of nanophotonics will have significant impacts on the life sciences and medicine alike. Given its scope, the book offers a valuable asset for researchers, scientists, engineers, and graduate students in the fields of biomedical engineering, electrical engineering, materials sciences, optics, biology, and medicine.
    Type of Medium: Online Resource
    Pages: V, 282 p. 160 illus., 126 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811561375
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Botany. ; Plant genetics. ; Plant ecology. ; Plant Science. ; Plant Genetics. ; Plant Ecology.
    Description / Table of Contents: Preface -- Acknowledgement -- Chapter 1. Taxonomic History -- Chapter 2. Morphology -- Chapter 3. Biology -- Chapter 4. Economic Importance -- Chapter 5. Phylogeny, classification, and biogeography -- Chapter 6. Taxonomic revision -- Chapter 7. Conservation status.
    Abstract: This book provides essential information on the morphology, biology, phytochemistry, pharmaceutical prospects, evolution, phylogeny, biogeography, and taxonomy of Paris (Melanthiaceae), a morphologically distinctive plant genus with great economic importance. Since the establishment of this genus, 70 species and 24 subspecific taxa have been described, resulting in considerable confusion in species delimitation. In this book, the taxonomy of all described taxa is carefully revised. Based on multi-disciplinary evidences, a revised classification system of Paris containing five sections is outlined. Every species is provided with a concise but diagnostic description, a color illustration, photographs that highlight distinguishing characters, examined specimens and distribution range. The interspecific relationships are clarified with an identification key. This monograph offers taxonomists, evolutionary biologists, ecologists, horticulturalists, phytochemists, and practitioners a thorough and up-to-date overview about this interesting plant group. It is equally valuable for undergraduate and graduate students, teachers and professionals engaged in related fields.
    Type of Medium: Online Resource
    Pages: XIII, 203 p. 134 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811579035
    DDC: 580
    Language: English
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    Keywords: Conservation biology. ; Ecology . ; Biotic communities. ; Population biology. ; Animal migration. ; Conservation Biology. ; Theoretical and Statistical Ecology. ; Community and Population Ecology. ; Animal Migration.
    Description / Table of Contents: Chapter 1. The conservation issue -- Chapter 2. Development of hierarchical spatial models for assessing ungulate abundance and habitat relationships -- Chapter 3. Model-based assessment of ungulate-habitat relationships -- Chapter 4. Assessing threats to ungulates and management responses -- Chapter 5. Conservation of tropical forest ungulates: the way forward.
    Abstract: Large ungulates in tropical forests are among the most threatened taxa of mammals. Excessive hunting, degradation of and encroachments on their natural habitats by humans have contributed to drastic reductions in wild ungulate populations in recent decades. As such, reliable assessments of ungulate-habitat relationships and the spatial dynamics of their populations are urgently needed to provide a scientific basis for conservation efforts. However, such rigorous assessments are methodologically complex and logistically difficult, and consequently many commonly used ungulate population survey methods do not address key problems. As a result of such deficiencies, key parameters related to population distribution, abundance, habitat ecology and management of tropical forest ungulates remain poorly understood. This book addresses this critical knowledge gap by examining how population abundance patterns in five threatened species of large ungulates vary across space in the tropical forests of the Nagarahole-Bandipur reserves in southwestern India. It also explains the development and application of an innovative methodology – spatially explicit line transect sampling – based on an advanced hierarchical modelling under the Bayesian inferential framework, which overcomes common methodological deficiencies in current ungulate surveys. The methods and results presented provide valuable reference material for researchers and professionals involved in studying and managing wild ungulate populations around the globe. .
    Type of Medium: Online Resource
    Pages: XXVII, 195 p. 46 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811569340
    DDC: 333.9516
    Language: English
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  • 34
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Conservation biology. ; Ecology . ; Agriculture. ; Environmental health. ; Botany. ; Landscape ecology. ; Conservation Biology. ; Agriculture. ; Environmental Health. ; Plant Science. ; Landscape Ecology.
    Description / Table of Contents: Chapter1. Taming the Land, A Historical Perspective -- Chapter2. The Ecological Connection in Farming, Ranching, and Gardening -- Chapter3. Hydrology and Erosion Processes -- Chapter4. Cover Crop Dynamics on Hydrology and Erosion -- Chapter5. Vegetation Effects on Hydrology and Erosion: Grazinglands -- Chapter6. Organic Matter: The Whole Truth and Nothing but the Truth -- Chapter7. Soil-Hydrology-Plant Assessment Technologies for Cropland, Rangeland, Pastureland, and Gardens.
    Abstract: This book explores the importance of soil health in croplands, rangelands, pasturelands, and gardens, and presents new methods and technologies for assessing soil dynamics and health in these different land types. Through perspectives of agriculture, soil management, and ecological sustainability, the book provides accurate and up-to-date information on soil health assessment and maintenance that is often missing from current literature on conservation and environmental management and preservation. The book is written in a clear and concise format, and will appeal to non-scientists interested in soil health, as well as professional farmers, ranchers and gardeners. The book begins by discussing soil health from a historical perspective, and in terms of how it is covered in the news currently. Then the author addresses the ecological implications of soil health in farming, ranching and gardening, and comprehensively details the physical, chemical and biological properties of soil as they apply in various land types. The book then examines soil health assessment using new diagnostic and analytic technologies, and how these new innovations will be necessary going forward to maintain and improve soil health. .
    Type of Medium: Online Resource
    Pages: IX, 370 p. 119 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030403980
    DDC: 333.9516
    Language: English
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  • 35
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Biochemical markers. ; Immunotherapy. ; Cancers. ; Biomarkers. ; Immunotherapy.
    Description / Table of Contents: 1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy -- 2 immune composition of gastrointestinal tract of Gut -- 3 Immunomarkers for detection of GI malignancies -- 4 Immuno-therapeutics of gastrointestinal malignancies -- 5 Immune cell therapy against gastrointestinal tract cancers -- 6 Immune checkpoint inhibitors in gastrointestinal malignancies -- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers -- 8 Therapeutic Vaccines for Gastrointestinal Malignancies -- 9 Immuno-Oncology of Oesophageal Cancer -- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies -- 11 Immuno-oncology of colorectal cancer -- 12 Immune targets in colorectal cancer -- 13 Applications of computational biology in gastrointestinal malignancies. .
    Abstract: This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. .
    Type of Medium: Online Resource
    Pages: XII, 251 p. 34 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564871
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    DDC: 571.978
    Language: English
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  • 36
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Reproduction. ; Physiology. ; Anatomy. ; Cytology. ; Human Physiology. ; Reproductive Physiology. ; Anatomy. ; Cell Biology.
    Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: Origin and development of the breast -- Chapter 3: Structure of the lactating breast -- Chapter 4: Breast function during the initial period of lactation (lactogenesis I and II) -- Chapter 5: The period of established lactation (lactogenesis III).
    Abstract: This comprehensive Monograph examines all peripheral and central mechanisms of regulating the secretion of milk from the lactating breast. The author reviews the complete female breast development, starting with the early childhood, up to pregnancy and lactation. Structural and ultrastructural data on the alveolar-ductal system, together with details of breast innervation, are used to investigate the physiological process of lactation. Readers will appreciate the special focus on reflexes, both in the child and the mother, that help to regulate maternal milk production and secretion. Following this, the author sheds a light on the composition and dynamics of milk components during the different periods of lactation. The final section of this volume focusses on practical aspects of modern breastfeeding, like the use of breast pumps or galactogogues, to influence the productivity of milk production. These fundamental principles and structural details will be particularly useful for physiologists and clinicians working in gynecology and pediatrics.
    Type of Medium: Online Resource
    Pages: VIII, 254 p. 87 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663643
    DDC: 612
    Language: English
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  • 37
    Keywords: Microbiology. ; Biotechnology. ; Refuse and refuse disposal. ; Microbiology. ; Biotechnology. ; Waste Management/Waste Technology.
    Description / Table of Contents: Part 1 Introductory Chapters -- 1 Emerging Frontiers of Microbes as Agro-waste Recycler -- 2 Microbes: the next generation bioenergy producers -- 3 Emerging and eco-friendly approaches for waste management -- 4 Ecofriendly microbial biofuel production from waste -- 5 Bioremediation: Current research trends and applications -- 6 Bioremediation: an approach for environmental pollutants detoxification -- 7 Bioethanol extraction and its production from agricultural residues for sustainable development -- Part 2 Biotechnological approaches -- 8 Byproduct valorization of vegetable oil industry through biotechnological approach -- 9 Omics tools: Approaches for microbiomes analysis to enhance bioenergy production -- 10 Omics (genomics, proteomics, metabolomics etc.) tools to study the environmental microbiome and Bioremediation -- Part 3 Industrial waste management -- 11 Microalgae: Omics approaches for biofuel production and biomedical research -- 12 Waste Utilization and Minimization in Food Industry.-13 Ligninolytic microbes and their role in effluent management of pulp and paper industry -- 14 Production of Polyhydroxyalkanoates using waste as raw materials. 15 Newer Aspects of Waste-to-Valorisation Technologies in Food Industry -- 16 Xylanase in waste management and its industrial applications -- 17 Organic Acid Production from Agricultural Waste. .
    Abstract: This book addresses waste generation problems from various sectors, including industries, agriculture, and household. It focuses on how modern biotechnological approaches could help manage waste in an eco-friendly manner and generate precious bioenergy. It discusses the inadequate waste management systems damaging the environment and its adverse impacts on climate change-related problems. This book covers all the essential information regarding various types of waste and their management. It is a comprehensive compilation for understanding the efficient generation of bioenergy. It is a relevant reading material (resource) for anyone who wishes to study waste management as Chemist, Biologist, Biotechnologist, Industrialist, Ecologist, Microbiologist, Economist, and all disciplines related to the environment.
    Type of Medium: Online Resource
    Pages: VIII, 438 p. 60 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813343474
    DDC: 579
    Language: English
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  • 38
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Food Microbiology. ; Food science. ; Food Microbiology. ; Food Science.
    Description / Table of Contents: Chapter One Why encapsulate antioxidants in emulsion-based systems, where they are located, and how location affects their efficiency -- Chapter Two High-energy emulsification methods for encapsulation of lipid-soluble antioxidants -- Chapter Three Low-energy emulsification methods for encapsulation of antioxidants -- Chapter Four Nanoemulsions as carriers for natural antioxidants: formulation development and optimization -- Chapter Five Microemulsions as antioxidant carriers -- Chapter Six Membrane emulsification for encapsulation of bioactives: Application to the encapsulation of antioxidants -- Chapter Seven Encapsulation of antioxidants using double emulsions -- Chapter Eight Stability and release behavior of bioactive compounds (with antioxidant activity) encapsulated by Pickering emulsion -- Chapter Nine Advances in the oxidative stability mechanisms of emulsions -- Chapter Ten The role of antioxidants and encapsulation processes in omega-3 stabilization -- Chapter Eleven Encapsulation of pigmented lipophilic antioxidants through micro and nanoemulsions -- Chapter Twelve Characterization techniques for emulsion-based antioxidant carriers with biomedical applications.
    Abstract: The limited aqueous solubility of bioactive pharmaceutical ingredients presents a tremendous challenge in the development of new drugs. In recent years, methods have been developed to protect these sensitive bioactive compounds, namely antioxidants, with the aim of increasing the public sanitation grades. Emulsion-based systems are particularly interesting as colloidal delivery encapsulation systems, because they can easily be created from food-grade ingredients using relatively simple processing protocols. It is one of the most favorable delivery systems to increase the solubility of phytochemicals, nutraceuticals and food additives. Emulsion‐based Encapsulation of Antioxidants: Design and Performance advances the field of colloid science through the investigation of the effects of formulation and process parameters that influence emulsion production. The book offers a deeper comprehension of the technological and biological aspects of the incorporation of encapsulated compounds in food matrices and explication of their activity. Chapters provide an overview of the status of emulsion-based formulations to encapsulate antioxidants, fabrication, properties, applications, and biological fate with emphasis on systems suitable for utilization within industry. Special emphasis is placed on the antioxidant activity of the carriers being the key advantage of these emulsion-based systems. The main aim of the book is to inspire and to guide fellow scientists and students in this field. Filled with illustrations, figures, case studies, practical examples, and historical perspectives, the book can also be used as a practical handbook or graduate textbook. For industry professionals, the book presents easy-to-achieve approaches to industrial pharmaceutical production. .
    Type of Medium: Online Resource
    Pages: XIII, 473 p. 96 illus., 75 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030620523
    Series Statement: Food Bioactive Ingredients,
    DDC: 664.001579
    Language: English
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    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Biotechnology. ; Enzymology. ; Bioorganic chemistry. ; Protein Biochemistry. ; Chemical Bioengineering. ; Enzymology. ; Bioorganic Chemistry.
    Description / Table of Contents: Preface -- Chapter 1: Introduction -- Chapter 2: Enzyme Cascade Design – Retrosynthesis Approach -- Chapter 3 : Multi-Enzymatic Cascades in vitro -- Chapter 4: Multi-Enzymatic Cascades in vivo -- Chapter 5: Chemo-Enzymatic Cascades -- Chapter 6: Enzyme Cascade Kinetic Modelling -- Chapter 7: Enzyme Cascade Reaction Engineering -- Chapter 8: Enzyme Cascade Process Design and Modelling -- Chapter 9: Enzyme Cascade Reaction Monitoring And Control -- Chapter 10: Cascade reactions in non-conventional media -- Chapter 11: Perspectives.
    Abstract: This book provides a comprehensive overview of the recent developments achieved in the field of chemo/enzymatic cascades with topics spanning from design (in vitro and in vivo) to kinetic- and process modelling as well as process control. Opportunities and challenges of building multi-step chemo/enzymatic reactions are discussed, whereby the latter are critically assessed in each chapter and methods to ease the implementation are explored. Both, multi-enzymatic cascades and chemo-enzymatic cascades are presented with the motivation of combining the strengths of these two worlds (e.g. selectivity, activity and robustness) not neglecting the obstacles and challenges of such endeavour. Furthermore, the use of non-conventional media for catalytic cascade reactions, recent achievements and potential for future developments in a technical environment are addressed.
    Type of Medium: Online Resource
    Pages: VII, 181 p. 103 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030657185
    DDC: 572.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Spectrum analysis. ; Pharmaceutical chemistry. ; Nutrition   . ; Biomedical Research. ; Radiology. ; Spectroscopy. ; Pharmaceutics. ; Nutrition.
    Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.
    Abstract: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.
    Type of Medium: Online Resource
    Pages: X, 72 p. 32 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641986
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 610.72
    Language: English
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  • 42
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.
    Abstract: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .
    Type of Medium: Online Resource
    Pages: XI, 211 p. 24 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813367852
    Series Statement: Advances in Experimental Medicine and Biology, 1316
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Radiology. ; Diseases. ; Bioinformatics. ; Immunology. ; Human Physiology. ; Radiology. ; Diseases. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. The Economics of Obesity-A Public Policy Perspective -- Chapter 3. Obesity and skin problems -- Chapter 4. Obesity and endometriosis -- Chapter 5. Hypogonadism -- Chapter 6. Effect of obesity in cardiovascular system -- Chapter 7. Impact of obesity on vaccination -- Chapter 8. Obesity-linked diseases (Comorbidities) -- Chapter 9. Imaging as a tool for measuring body fat -- Chapter 10. Extrapolation from clinical trial to practice: current pharmacotherapy on obesity -- Chapter 11. Nanotechnology in the context of obesity -- Chapter 12. Computational approach in drug development for obesity.
    Abstract: This book summarizes the effects of obesity on health and its correlation with a wide range of debilitating and life-threatening conditions in humans. It discusses the possible pathological mechanisms that are involved in the development of obesity and highlights obesity-associated molecular mechanisms that contribute to reproductive dysfunctions in men and women. The book provides mechanistic insights on the role of obesity in cardiovascular and respiratory disorders, and examines the role of the complementary molecular mechanism of the gut microbiota in the development of obesity. It also reviews the interaction between the metabolic system and immune cells in the pathogenesis of obesity-associated diseases. Lastly, it assesses the latest advances in nanomedicine as an emerging strategy for the treatment of obesity.
    Type of Medium: Online Resource
    Pages: XVI, 181 p. 13 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813364080
    DDC: 612
    Language: English
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    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    DDC: 615
    Language: English
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  • 45
    Keywords: Plants Development. ; Landscape ecology. ; Plants Evolution. ; Biodiversity. ; Plant physiology. ; Plant Development. ; Landscape Ecology. ; Plant Evolution. ; Biodiversity. ; Plant Physiology.
    Description / Table of Contents: Part 1.Cryopreservation and Biotechnology -- 1.Cryopreservation Development of some endangered Thai Orchid species -- 2.Status of Orchid Industry in India -- 3.Cryobiotechnological studies in Vanilla, the orchid of multi- industrial uses -- 4.In vitro propagation and germplasm conservation of wild orchids from South America -- 5.Postharvest Technology of cut-flowers of Orchids -- 6.Cryobiotechnology of Korean orchid biodiversity: a case study using Cymbidium kanra -- Part 2.Orchid Biodiversity and Conservation -- 7.Species diversity and distribution of Orchids in district Rudraprayag, Uttarakhand, North East Himalaya, India -- 8.Status of genetic diversity and its characterization in genus Bulbophyllum (Orchidaceae) from North-Eastern India -- 9.Orchid diversity in Darjeeling Himalaya, India: Present status and conservation -- 10.Orchid Diversity in the Eastern Ghats of Northern Andhra Pradesh, India -- 11.History and Scientific Potential of the Orchid Collection of the Stoсk Greenhouse of the Main Botanical Garden RAS (Moscow, Russia) -- 12.Status of Orchid Diversity, Conservation, Research and Development in Arunachal Pradesh – An Overview -- Part 3. Anatomy and Physiology -- 13.Orchid mycorrhizal fungi- structure, function, and diversity -- 14.Orchid Seed Ultra structure: Ecological and Taxonomic Implications with reference to Epidendroideae (Orchidaceae) -- 15.Structural Adaptations of Bulbophyllum and Dendrobium (Orchidaceae) to the Epiphytic Habitat and their Phylogenetic Implications -- 16.Physiological response of Dendrobium cv. Earsakul to plant growth promoters and growing systems -- 17.Anatomical studies in some Indian Coelogyneae (Orchidaceae)., Part 4. Pollination Biology -- 18.Beauty of Orchid Flowers: Are not adequate to lure Indian biologists? -- 19.Evolution of Organismal Female Wasp Mimics in Sexually Deceptive Orchid genus Chiloglottis (Orchidaceae) -- 20.Pollination studies in the genus Habenaria Willd. (Orchidaceae) from Western Ghats -- Part 5. Orchid Chemicals and Bioactive Compounds -- 21.Phytochemical analysis, antioxidant and anti-inflammatory activity of Eria tomentosa (Koen.) Hook. f -- 22.Medicinal orchids: production of bioactive compounds and biomass -- 23.Ethnomedicinal aspects of some Orchids from Darjeeling Himalaya, India -- 24.Evaluation of Phytoconstituents and Antibacterial activity of Vanda tessellata using in vitro model -- 25.Screening of Bioactive Phytochemicals in some Indigenous Epiphytic Orchids of Bangladesh -- 26.GC-MS analysis of organic extracts of Cymbidium aloifolium (L.) Sw. (Orchidaceae) leaves from Eastern Ghats of India -- 27.Anticancer property in Acampe praemorsa and Aerides odorata (Orchidaceae), an in vitro approach -- 28.Phytochemical Screening and Evaluation of Antimicrobial Potential of Dendrobium fimbriatum Hook.
    Abstract: This book on “Orchid Biology: Recent Trends & Challenges” reviews the latest strategies for the preservation and conservation of orchid diversity and orchid germplasm. It is an outcome of the Proceedings of the International Symposium on “Biodiversity of Medicinal Plants & Orchids: Emerging Trends and Challenges” held on 9-11 February 2018 at Acharya Nagarjuna University, India. In addition, eminent orchid experts from around the globe were invited to contribute to this book. All chapters were peer-reviewed by international experts. The Orchidaceae are one of the largest families of flowering plants, comprising over 700 genera and 22,500 species and contributing roughly 40 percent of monocotyledons. They also represent the second-largest flowering plant family in India, with 1,141 species in 166 genera, and contribute roughly 10% of Indian flora. Orchids comprise a unique group of plants and their flowers are among the most enchanting and exquisite creations of nature. Phylogenetically and taxonomically, the Orchidaceae are considered to be a highly evolved family among angiosperms. They show incredible diversity in terms of the shape, size and colour of their flowers, and are of great commercial importance in floriculture markets around the globe. Millions of cut flowers of Cymbidium, Dendrobium, Cattleya, Paphiopedilum, Phalaenopsis, Vanda etc., besides potted orchid plants, are sold in Western Countries and thus, the orchid cut flower industry has now become a multimillion-dollar business in Europe, the USA and South East Asia. Besides their ornamental value, orchids hold tremendous pharmaceutical potential. Root tubers of Habenaria edgeworthii form an important component of the ‘Astavarga’ group of drugs in Ayurvedic medicine. It is an established fact that tubers of some terrestrial orchids have been used to treat diarrhoea, dysentery, intestinal disorders, cough, cold and tuberculosis. Some orchids, particularly those belonging to the genera Aerides, Arachnis, Cattleya, Cymbidium, Dendrobium, Epidendrum, Oncidium, Paphiopedilum, Phalaenopsis, Renanthera, Vanda etc. have been extensively used to produce internationally acclaimed hybrids. Yet paradoxically, Indian orchids are victims of their own beauty and popularity. As a result, their natural populations have been declining rapidly because of unbridled commercial exploitation in India and abroad. In fact, some orchids are now at the verge of extinction, e.g. Renanthera imschootiana, Diplomeris hirsuta, Paphiopedilum fairrieanum, Cypripedium elegans, Taeniophylum andamanicum etc. Given the global importance of orchids in terms of securing human health and wealth, this comprehensive compilation, prepared by international experts, is highly topical. Its content is divided into five main sections: (I) Cryopreservation & Biotechnology, (II) Orchid Biodiversity & Conservation, (III) Anatomy & Physiology, (IV) Pollination Biology and (V) Orchid Chemicals & Bioactive Compounds. All contributions were written by eminent orchid experts/professors from around the world, making the book a valuable reference guide for all researchers, teachers, orchid enthusiasts, orchid growers and students of biotechnology, botany, pharmaceutical sciences and ethnomedicine. It will be equally valuable for readers from the horticultural industry, especially the orchid industry, agricultural scientists and policymakers.
    Type of Medium: Online Resource
    Pages: XVIII, 547 p. 133 illus., 113 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813294561
    DDC: 571.82
    Language: English
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    Keywords: Conservation biology. ; Ecology . ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Water. ; Hydrology. ; Sustainability. ; Applied ecology. ; Agriculture. ; Conservation Biology. ; Environmental Engineering/Biotechnology. ; Water. ; Sustainability. ; Applied Ecology. ; Agriculture.
    Description / Table of Contents: Preface -- 1. Causes and Effects of Pesticide and Metal Pollution on Different Ecosystems -- 2. Ecotoxicology of Heavy Metals: Sources, Effects and Toxicity -- 3. Role of Modern Innovative Techniques for Assessing and Monitoring Heavy Metal and Pesticide Pollution in Different Environments -- 4. Global Scenario of Remediation Techniques to Combat Pesticide Pollution -- 5. Mycoremediation: A Sustainable Approach for Pesticide Pollution Abatement -- 6. Bio-pesticides: Application and Possible Mechanism of Action -- 7. Values of Biofertilizers for Sustainable Management in Agricultural Industries -- 8.Role of Macrophytes in Spontaneous Lacustrine Phytofiltration -- 9. Phytoremediation of Heavy Metals Using Salix (Willows) -- 10. Photo catalysis: An Effective Tool for Treatment of Dyes Contaminated Wastewater -- 11. Removal of dyes from waste water by Micellar Enhanced Ultrafiltration -- 12. Biofilm: an innovative modern technology for aquatic pollution remediation -- 13. Heavy Metal Soil Contamination and Bioremediation -- 14. Environmental Biotechnology: For Sustainable Future -- 15. Global Environmental Regulations for Management of Pesticides -- Index.
    Abstract: This book addresses the grave concerns stemming out due to conventional treatment techniques. The main focus of this book revolves round the central kernel of novel technology (bioremediation and biotechnology) which has emerged as an independent warrior to clean up and restore the disturbed environs. Furthermore, this book is a coherent assortment of diverse chapters relevant to the role of biotechnology and bioremediation for restoration of the ecosystems degraded by pesticide and heavy metal pollution. The inaugural chapters deal with the quantification of problem and its magnitude due to pesticides and heavy metals, followed by innovative modern biotechnological and bioremediation treatment technologies and sustainable techniques to remediate the persistent pollutants. It is a detailed comprehensive account for the treatment technologies from unsustainable to sustainable. Academicians, researchers and students shall find it as a complete wrap up regarding biotechnological intervention for sustainable treatment of pollution and shall suffice for the diverse needs of teaching and research.
    Type of Medium: Online Resource
    Pages: XVI, 278 p. 38 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030403331
    DDC: 333.9516
    Language: English
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    Keywords: Bacteria. ; Biomaterials. ; Nucleic acids. ; Proteins. ; Medical microbiology. ; Bacteria. ; Nucleic Acid. ; Proteins. ; Medical Microbiology.
    Description / Table of Contents: Part I:Biochemistry/Structural Biology – Enzymes -- Chapter 1: Cyclic Dinucleotide Signaling In Mycobacteria -- Chapter 2: Structure and regulation of EAL domain proteins -- Chapter 3: Insights into the molecular basis of biofilm dispersal from crystal structures of di-domain containing proteins -- Chapter 4: Structure and function of HD-GYP phosphodiesterases -- Chapter 5: A unified catalytic mechanism for c-di-NMP hydrolysis by DHH/DHHA1 phosphodiesterases -- Chapter 6: Enzymatic degradation of linear dinucleotide intermediates of cyclic dinucleotides -- Part II:Biochemistry/Structural Biology – Receptors -- Chapter 7: Detection of cyclic dinucleotide binding proteins -- Chapter 8: Non-canonical c-di-GMP binding modes -- Part III:Biochemistry/Structural Biology – Sensing -- Chapter 9: Sensory domains that control cyclic di-GMP-modulating proteins: a critical frontier in bacterial signal transduction -- Part IV:Cyclic di-AMP biochemistry and physiology -- Chapter 10: Metabolic regulation by cyclic di-AMP signaling -- Chapter 11: Osmoregulation via cyclic-di-AMP signaling -- Part V:Population diversity -- Chapter 12: Measuring individual cell c-di-GMP: Identifying population diversity and c-di-GMP heterogeneity.-Part VI:Cyclic di-GMP and exopolysaccharide regulation -- Chapter 13: Activation of bacterial cellulose biosynthesis by cyclic-di-GMP -- Chapter 14: The Regulation of Alginate Biosynthesis viaC-di-GMPSignaling -- Part VII:Environmental bacteria -- Chapter 15: Cyclic di-GMP Signaling in Bacillus subtilis -- Chapter 16: C-di-GMP signaling systems in the Gram-positive Bacillus cereus group -- Chapter 17: Cyclic-di-AMP in Bacillus subtilisbiofilm formation.-Chapter 18: Regulation by c-di-GMP in Myxococcusxanthus -- Chapter 19: Light-regulated nucleotidesecond messenger signalingin cyanobacteria -- Chapter 20: C-di-GMP-dependent regulation of antibiotic biosynthesis in Lysobacter -- Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria -- Part VIII:Pathogens -- Chapter 22: Signals modulating cyclic di-GMP pathways in Vibrio cholera -- Chapter 23: Cyclic di-GMP regulation of gene expression -- Chapter 24: Cyclic di-GMP signaling in Salmonella enterica serovar Typhimurium -- Chapter 25: Cyclic di-GMP signaling in the phytopathogen Xanthomonas campestris pv. Campestris -- Chapter 26: Cyclic di-AMP in Mycobacterium tuberculosis -- Chapter 27: Cyclic di-AMP signaling in Streptococcus pneumonia -- Part IX:Gram-negative bacteria -- Chapter 28: Regulation of cyclic-di-GMP signaling in Pseudomonas aeruginosa -- Chapter 29: Unconventional Cyclic di-GMPSignalling in Escherichia coli -- Chapter 30: Cyclic di-GMP in Burkholderia spp -- Chapter 31: Cyclic di-GMP and the regulation of biofilm dispersion -- Part X:Cyclic di-GMP signaling in eukaryotes -- Chapter 32: Cyclic-di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formationin Dictyostelium -- Part XI:Interference Strategies -- Chapter 33: Targeting cyclic di-nucleotide signaling with small molecules -- Part XII:Novel cyclic di-nucleotides -- Chapter 34: Cyclic di-GMP signaling gone astray: cGAMP signaling via Hypr GGDEF and HD-GYP enzymes -- Chapter 35: Microbial cyclic GMP-AMP signaling pathways.-Part XIII:Honorary cyclic nucleotides -- Chapter 36: 2’,3’-cyclic mononucleotide metabolism and possible roles in bacterial physiology -- Part XIV:Horizontal gene transfer -- Chapter 37: Horizontal transfer of c-di-GMP associated genes. Theoretical underpinnings and future perspectives.-Part XV:Conclusion -- Chapter 38: Conclusion. .
    Abstract: This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.
    Type of Medium: Online Resource
    Pages: XVIII, 657 p. 108 illus., 96 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030333089
    DDC: 579.3
    Language: English
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  • 48
    Keywords: Botany. ; Forestry. ; Botanical chemistry. ; Biotic communities. ; Plant genetics. ; Plant physiology. ; Plant Science. ; Forestry. ; Plant Biochemistry. ; Ecosystems. ; Plant Genetics. ; Plant Physiology.
    Description / Table of Contents: 1. Nitrogen and Sulfur Metabolism in Microalgae and Plants: 50 Years of Research -- 2. Progress Toward Deep Sequencing-Based Discovery of Stress-Related MicroRNA in Plants and Available Bioinformatics Tools -- 3. Recent Advances in MS-Based Plant Proteomics: Proteomics Data Validation Through Integration with Other Classic and -Omics Approaches -- 4. Membrane Trafficking and Plant Signaling -- 5. Molecular Aspects of Iron Nutrition in Plants -- 6. Urea in Plants: Metabolic Aspects and Ecological Implications -- 7. Biosynthesis and Regulation of Secondary Cell Wall -- 8. Stress-Induced Microspore Embryogenesis in Crop Plants: Cell Totipotency Acquisition and Embryo Development -- 9. Potential of Microalgae Biomass for the Sustainable Production of Bio-commodities -- 10. Crassulacean Acid Metabolism and Its Role in Plant Acclimatization to Abiotic Stresses and Defence Against Pathogens -- 11. The Role of the Shikimate and the Phenylpropanoid Pathways in Root-Knot Nematode Infection -- 12. Functional Diversity of Photosynthesis, Plant-Species Diversity, and Habitat Diversity -- 13. When the Tree Let Us See the Forest: Systems Biology and Natural Variation Studies in Forest Species -- 14. The Ecological Importance of Winter in Temperate, Boreal, and Arctic Ecosystems in Times of Climate.
    Abstract: With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences. The present volume includes reviews on plant physiology, biochemistry, genetics and genomics, forests, and ecosystems.
    Type of Medium: Online Resource
    Pages: XIII, 399 p. 47 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030363277
    Series Statement: Progress in Botany, 81
    DDC: 580
    Language: English
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  • 49
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Introduction Food and Brain -- 2. Food and Behavior -- 3. Food and Psychological Wellbeing -- 4. Food and Cognition -- 5. Autism and Food -- 6. Healthy Brains: Types of Food and their Active Pharmacological Ingredients -- 5. Dieting: Importance of Diet and Diet Types -- 6. Nutrigenomics -- 7. Epigenetics -- 8. Gut Microbiota (microbiome) -- 9. Personalized Nutrition -- 10. Vegetables -- 11. Fruits -- 12. Nuts, Seeds and Spices -- 13. Grains [Oats, Barley & Quinoa] -- 14. Seafood [fish like Salmon, Oyster, Sea vegetables (algae)] -- 15. Other -- 16. Autism Management through Food and Diet -- 17. Personalized Nutrition Therapy.
    Abstract: The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.
    Type of Medium: Online Resource
    Pages: XX, 693 p. 111 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030304027
    Series Statement: Advances in Neurobiology, 24
    DDC: 612.8
    Language: English
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  • 50
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biodiversity. ; Animal migration. ; Conservation biology. ; Ecology . ; Animal culture. ; Biodiversity. ; Animal Migration. ; Conservation Biology. ; Animal Science.
    Description / Table of Contents: Foreword -- Preface -- Acknowledgements -- About the Authors -- List of Reviewers -- Chapter 1. The History and Distinctions of Conservation Biology -- Chapter 2. Biodiversity: Concept, Measurement, and Management -- Chapter 3. Human Presence and the Need for Conservation -- Chapter 4. Climate Change and its Impact on Conservation -- Chapter 5. Conservation Genetics -- Chapter 6. The Conservation of Populations: Theory, Analysis, Application -- Chapter 7. The Conservation of Terrestrial Habitat and Landscapes -- Chapter 8. The Conservation of Aquatic Systems -- Chapter 9. Conservation Through Ecosystem Management -- Chapter 10. Values and Ethics in Conservation -- Chapter 11. Conservation Economics and Sustainable Development -- Chapter 12. The Legal Foundations of Conservation Biology -- Chapter 13. Conservation as Vocation -- Index.
    Abstract: This book provides a thorough, up-to-date examination of conservation biology and the many supporting disciplines that comprise conservation science. In this, the Third Edition of the highly successful Conservation Biology: Foundations, Concepts, Applications, the authors address their interdisciplinary topic as it must now be practiced and perceived in the modern world. Beginning with a concise review of the history of conservation, the authors go on to explore the interplay of conservation with genetics, demography, habitat and landscape, aquatic environments, and ecosystem management, and the relationship of all these disciplines to ethics, economics, law, and policy. An entirely new chapter, The Anthropocene: Conservation in a Human-Dominated Nature, breaks new ground in its exploration of how conservation can be practiced in anthropogenic biomes, novel ecosystems, and urban habitats. The Third Edition includes the popular Points of Engagement discussion questions used in earlier editions, and adds a new feature: Information Boxes, which briefly recap specific case histories described in the text. A concluding chapter offers insight into how to become a conservation professional, in both traditional and non-traditional roles. The authors, Fred Van Dyke and Rachel Lamb, draw on their expertise as field biologists, wildlife managers, consultants to government and industry, and scholars of environmental law, policy, and advocacy, as well as their many years of effective teaching experience. Informed by practical knowledge and acquired skills, the authors have created a work of exceptional clarity and readability which encompasses both systemic foundations as well as contemporary developments in the field. Conservation Biology: Foundations, Concepts, Applications will be of invaluable benefit to undergraduate and graduate students, as well as to working conservation scientists and managers. This is an amazing resource for students, faculty, and practitioners both new and experienced to the field. Diane Debinski, PhD Unexcelled wisdom for living at home on Wonderland Earth, the planet with promise, destined for abundant life. Holmes Rolston, PhD Van Dyke and Lamb have maintained the original text’s emphasis on connecting classical ecological and environmental work with updated modern applications and lucid examples. But more importantly, the third edition contains much new material on the human side of conservation, including expanded treatments of policy, economics, and climate change. Tim Van Deelen, PhD Fred Van Dyke and Rachel Lamb break new ground in both the breadth and depth of their review and analysis of this crucially important and rapidly changing field. Any student or other reader wishing to have a comprehensive overview and understanding of the complexities of conservation biology need look no further – this book is your starting point! Simon N. Stuart, PhD.
    Type of Medium: Online Resource
    Pages: XXXI, 613 p. 360 illus., 233 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030395346
    DDC: 333.95
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biodiversity. ; Physical geography. ; Biotic communities. ; Pollution. ; Ecology . ; Biodiversity. ; Physical Geography. ; Ecosystems. ; Pollution. ; Terrestial Ecology.
    Description / Table of Contents: Chapter 1 Introduction to Environment -- Chapter 2 Components of the Earth -- Chapter 3 Earth and its Resources -- Chapter 4 Basics of Ecosystem -- Chapter 5 Major Biochemical Cycles -- Chapter 6 Biodiversity and its Conservation -- Chapter 7 Air Pollution and its Mitigation -- Chapter 8 Pollution and its Mitigation -- Chapter 9 Soil Pollution and its Mitigation -- Chapter 10 Oil Pollution -- Chapter 11 Human Population and the Environment -- Chapter 12 Climate Change: Threat of Era.
    Abstract: This book provides a cross-sectoral, multi-scale assessment of different environmental problems via in-depth studies of the Indian subcontinent. Data collected from different ecosystems forms a strong foundation to explore the topics discussed in this book. The book investigates how mankind is presently under the appalling shadow of pollution, climate change, overpopulation and poverty. The continuing problem of pollution, loss of forests, disposal of solid waste, deterioration of environment, global warming and loss of biodiversity have made nations aware of environmental issues. Many countries are desperately trying to move away from this adverse situation through technological development and policy level approaches. Through a number of case studies the authors provide details of ground level observations of the most environmentally stressed regions in the Indian subcontinent and beyond.
    Type of Medium: Online Resource
    Pages: XIV, 478 p. 338 illus., 175 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030491314
    DDC: 333.95
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Evolution (Biology). ; Science History. ; Science Philosophy. ; Evolutionary Biology. ; History of Science. ; Philosophy of Science.
    Description / Table of Contents: Chapter 1: Context -- Chapter 2: A Talking Book -- Chapter 3: Setting the Stage -- Chapter 4: Neo-Darwinism, Expansion and Consolidation (1900-1980) -- Chapter 5: Criticism, Resistance, a Glimmer of Hope -- Chapter 6: Buying Time -- Chapter 7: Making Space -- Chapter 8: Conflict Resolution -- Chapter 9: Evolutionary Transitions -- Chapter 10: The Stockholm Paradigm -- Chapter 11: Putting Evolution to Work.
    Abstract: This book presents a unified evolutionary framework based on three sets of metaphors that will help to consolidate discussions on evolutionary transitions. Evolution is the unifying principle of life, making identifying ways to apply evolutionary principles to tackle existence-threatening crises such as climate change crucial. A more cohesive evolutionary framework will further the discussions in this regard and also accelerate the process itself. This book lays out a framework based on three dualistic classes of metaphors – time, space, and conflict resolution. Evolutionary transitions theory shows how metaphors can help us understand selective diversification, as Darwin described with his “tree of life”. Moreover, the recently proposed Stockholm paradigm demonstrates how metaphors can help shed light on the emergence of complex ecosystems that Darwin highlighted with his “tangled bank” metaphor. Taken together, these ideas offer proactive measures for coping with existential crises for humanity, such as climate change. The book will appeal to biologists, philosophers and historians alike.
    Type of Medium: Online Resource
    Pages: XVII, 273 p. 33 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030520861
    Series Statement: Evolutionary Biology – New Perspectives on Its Development, 2
    DDC: 576.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Forestry. ; Plant Genetics. ; Plant Biotechnology. ; Forestry.
    Description / Table of Contents: Introduction -- The White spruce genome -- Targeted and whole genome re-sequencing for population and evolutionary genomic inferences in Norway spruce -- Transposable elements in Spruce -- An intact, but dormant LTR retrotransposon defines a moderately-sized family in white spruce (Picea glauca) -- The DNA methylome of Norway spruce -- Epigenomics in Norway spruce -- Comparative Genomics of Spruce -- Comparative genomics with the comparisons of BACs between loblolly pine and white spruce -- Wood formation and genomic selection in white spruce, data imputation strategies -- Ecotypes in Norway spruce (“Genomics of adaptation to drought across the Central European range of Norway spruce“) -- Local adaptation in the interior spruce hybrid complex -- Genomics of secondary metabolism - Terpenoids in spruce (Evolutionary dynamics of TPS gene family in Chinese spruce) -- Lignin biosynthesis in Norway spruce as an anti-fungal defense -- Future prospects.
    Abstract: This book offers comprehensive information on the genomics of spruces (Picea spp.), naturally abundant conifer tree species that are widely distributed in the Northern Hemisphere. Due to their tremendous ecological and economic importance, the management of forest genetic resources has chiefly focused on conservation and tree improvement. A draft genome sequence of the 20-gigabase Norway spruce genome was published in the journal Nature in 2013. Continuous efforts to improve the spruce genome assembly are underway, but are hindered by the inherent characteristics of conifer genomes: high amounts of repetitive sequences (introns and transposable elements) in the genome and large gene family expansions with regards to abiotic stress, secondary metabolism and spruces' defense responses to pathogens and herbivory. This book presents the latest information on the status of genome assemblies, provides detailed insights into transposable elements and methylation patterns, and highlights the extensive genomic resources available for inferring population genomics and climate adaptation, as well as emerging genomics tools for tree improvement programs. In addition, this volume features whole-genome comparisons among conifer species, and demonstrates how functional genomics can be used to improve gene function annotations. The book closes with an outlook on emerging fields of research in spruce genomics.
    Type of Medium: Online Resource
    Pages: XIV, 218 p. 48 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030210014
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Agriculture. ; Food Microbiology. ; Plant physiology. ; Plant biotechnology. ; Agriculture. ; Food Microbiology. ; Plant Physiology. ; Plant Biotechnology.
    Description / Table of Contents: Chapter 1. Global Perspective on Agriculture-Food Security and Nutrition -- Chapter 2. Advanced Approaches for Biofortification -- Chapter 3. Biofortification for Nutrient Content and Aroma Enrichment in Rice (Oryza sativa L.) -- Chapter 4. Biofortification in Pulses -- Chapter 5. Biofortification in Vegetables -- Chapter 6. Biofortification in Fruits -- Chapter 7. Transgenic Bio-fortified Crops: Applicability and Challenges -- Chapter 8. Biofortification in Fodder crops -- Chapter 9. Global Scenario of Vitamin Deficiency and Human Health -- Chapter 10. Plant Polyphenols and Gut Bacteria: Role in Obesity-induced Metabolic Endotoxaemia and Inflammation. Chapter 11. Designer Microbes for Nutraceutical Application -- Chapter 12. Nutrigenomics Approaches to Control Metabolic Diseases and Challenges to Personalized Nutritional Intervention -- Chapter 13. Biotechnological Advances for Phytoremediation -- Chapter 14. Diagnostic Tools for Food Safety -- Chapter 15. Nanotechnology for Food: Regulatory Issues and Challenges.Chapter 16. Advances in Edible Fruits Coating Materials -- Chapter 17. Systems Biology Approaches for Food and Health -- Chapter 18. Advances of Next Generation Sequencing (NGS) technologies to enhanced the Biofortifications in crops.
    Abstract: This book presents biotechnological advances and approaches to improving the nutritional value of agri-foods. The respective chapters explore how biotechnology is being used to enhance food production, nutritional quality, food safety and food packaging, and to address postharvest issues. Written and prepared by eminent scientists working in the field of food biotechnology, the book offers authentic, reliable and detailed information on technological advances, fundamental principles, and the applications of recent innovations. Accordingly, it offers a valuable guide for researchers, as well as undergraduate and graduate students in the fields of biotechnology, agriculture and food technology. .
    Type of Medium: Online Resource
    Pages: IX, 450 p. 64 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811528743
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human physiology. ; Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human Physiology.
    Description / Table of Contents: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.
    Abstract: Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. .
    Type of Medium: Online Resource
    Pages: VII, 180 p. 16 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030580049
    Series Statement: Current Topics in Microbiology and Immunology, 428
    DDC: 615
    Language: English
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    Keywords: Plant physiology. ; Botanical chemistry. ; Cytology. ; Environment. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Plant Physiology. ; Plant Biochemistry. ; Cell Biology. ; Environmental Sciences. ; Environmental Engineering/Biotechnology.
    Description / Table of Contents: Chapter 1. Introduction -- PART I: Photosynthesis and Biomass Production under Changing World -- Chapter 2. Climate Change: Challenges to Reduce Global Warming and Role of Biofuels -- Chapter 3. The multifaceted connections between photosynthesis and mitochondrial metabolism -- Chapter 4. Regulation of assimilatory processes and distribution of energy for improved productivity -- Chapter 5. Strategies to enhance photosynthesis for the improvement of crop yields -- Chapter 6. Photosynthetic Acclimation and Adaptation to Cold Ecosystems -- Chapter 7. What is the limiting factor? – The key question for grain yield of maize as a renewable resource under salt stress -- PART II: Microalgae and engineered crops for production of biofuels and high-value products -- Chapter 8. Bio-production from microalgal resources -- Chapter 9. Hydrogen photoproduction in green algae: novel insights and future perspectives -- Chapter 10. Synthetic Biofuels and Green-House Gas Mitigation -- Chapter 11. Synthetic biology and future production of biofuels and high-value products -- PART III: Genetic resources and engineering methods to improve crop plants -- Chapter 12. Kinetics, genetics and heterosis -- Chapter 13. Genome information resources to improve plant biomass productivity -- Chapter 14. RNA interference: formproving traits and disease management in plants -- Chapter 15. Current transformation methods for genome editing applications in energy crop sugarcane -- Chapter 16. Development of transgenic sugarcane for insect resistance -- Chapter 17. Rapid Agrobacterium-mediated transformation of tobacco cotyledons using toothpicks Yuan-Yeu Yau, Mona Easterling and Lindsey Brennan -- Chapter 18. Genetic improvement of Jatropha curcas through conventional and biotechnological tools -- Chapter 19. Plant cell manipulation technology for bio-refinery. .
    Abstract: The use of fossil fuels results in rising CO2 and other greenhouse gas (GHG) emissions, causing global temperature rise and climate change that will negatively impact human health, the food supply, and eventually worsen hunger and misery. Presently, fossil fuels meet 88% of the energy demand, resulting in rising CO2/GHG emissions at alarming rates. The increased use of biofuels would help to mitigate climate change. Efficiently designing methods for the production of biofuels and plant-derived high-value products requires a deeper understanding of photosynthetic processes as a prerequisite for applying novel biotechnologies. Accordingly, this book provides ample information and a wealth of illustrative examples. The book’s eighteen richly illustrated chapters are divided into three thematic parts. I: Photosynthesis and Biomass Production under Changing Conditions, II: Microalgae and Engineered Crops for Production of Biofuels and High-value Products, and III: Genetic Resources and Engineering Methods to Improve Crop Plants. Readers will find the latest information on the molecular basis of photosynthetic processes in plants (including the regulatory principles that allow plants to maintain homeostasis under changing conditions), stress resistance and synthetic pathways. In addition, the basic principles of important biotechnologies, as well as examples of specially designed crops capable of growing under stress conditions with improved productivity, are presented. The book sets the course for future research in the field of biofuel development and production and provides both general and specific information for students, teachers, academic researchers, industrial teams, and general readers who are interested in new developments concerning the production of biofuels with value-added properties.
    Type of Medium: Online Resource
    Pages: XXVII, 490 p. 142 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811552281
    DDC: 571.2
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Medical genetics. ; Cancer. ; Lipids. ; Biomedical Research. ; Pharmacology. ; Medical Genetics. ; Cancer Biology. ; Lipidology.
    Description / Table of Contents: Preface -- Introduction of Druggable Lipid Signaling Pathway -- Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development -- Druggable Prostanoid Pathway -- Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress -- Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation -- Druggable Sphingolipid Pathway -- Druggable Lysophospholipid Pathway -- Druggable targets in endocannabinoid signaling -- Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections -- Druggable Lipid GPCRs: Past, Present, and Prospects. .
    Abstract: This edited work presents a series of reviews focusing on Druggable Lipid Signaling Pathways. It enables researchers in both academic institutions and industry as well as physicians to understand historical aspects of lipid signaling and future directions of drug discovery targeting lipid signaling pathways. This book provides 9 pathways including acyltransferases, prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, phosphoinositides, and lipid GPCRs. Readers will discover the importance of each lipid signaling pathway that contributes to broad range of diseases including neurological and neuropsychiatric diseases, pain, metabolic syndromes, cardiovascular diseases, cancer, dermatological diseases, fibrosis, inflammation, etc. Also, readers will recognize that many drugs targeting lipid signaling have been clinically used. Drugs currently under development are also discussed in each chapter, which includes some information about clinical trials and strategic drug designs. .
    Type of Medium: Online Resource
    Pages: VI, 260 p. 33 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506216
    Series Statement: Advances in Experimental Medicine and Biology, 1274
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.
    Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
    Abstract: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
    Type of Medium: Online Resource
    Pages: VII, 280 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811569302
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Cytology. ; Nanoscience. ; Biotechnology. ; Cell Biology. ; Nanophysics.
    Description / Table of Contents: Chapter 1: Introduction: Fluorescent materials for cell imaging -- Chapter 2: Semiconductor quantum dots for cell imaging -- Chapter 3: Carbon nanodots for cell imaging -- Chapter 4: Silicon nanoparticles for cell imaging -- Chapter 5: Fluorescent metal nanoclusters for bioimaging -- Chapter 6: Lanthanide-based upconversion nanoparticles for bioimaging applications -- Chapter 7: Conjugated polymers and polymer dots for cell imaging -- Chapter 8: Aggregation-induced emission (AIE) probes for cell imaging -- Chapter 9: Luminescent coordination compounds for cell imaging.
    Abstract: This book focuses on the latest fluorescent materials for cell imaging. Cell imaging is a widely used basic technique that helps scientists gain a better understanding of biological functions through studies of cellular structure and dynamics. In the past decades, the development of a variety of new fluorescent materials has significantly extended the applications of cellular imaging techniques. This book presents recently developed fluorescent materials, including semiconductor quantum dots, carbon dots, silicon nanoparticles, metal nanoclusters, upconversion nanoparticles, conjugated polymers/polymer dots, aggregation-induced emission (AIE) probes, and coordination compounds, used for various cellular imaging purposes. It will appeal to cell biologists and other researchers in academia, industry and clinical settings who are interested in the technical development and advanced applications of fluorescence imaging in cells, tissues and organisms to explore the mechanisms of biological functions and diseases.
    Type of Medium: Online Resource
    Pages: V, 247 p. 140 illus., 128 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811550621
    DDC: 660.6
    Language: English
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    Keywords: Fungi. ; Mycology. ; Microbiology. ; Plant biotechnology. ; Renewable energy sources. ; Biology Technique. ; Plant diseases. ; Fungi. ; Plant Biotechnology. ; Microbiology. ; Renewable Energy. ; Biological Techniques. ; Plant Pathology.
    Description / Table of Contents: Preface -- Biofuels: challenges and the promises of fungi in biofuel production -- Plant pathogenic fungi for bioethanol production: mechanisms of actions -- Plant pathogenic fungi for biodiesel production -- Plant pathogenic fungi for VOCs production -- Plant probiotic fungi as a new source for Bioethanol Production -- Endophytic fungi for biofuel production -- Brown and white rot fungi for biofuel production -- Gut fungi for biofuel production -- Consolidated bioprocessing: highly efficient fungi for biofuel production -- Process design in fungal-based biofuel production systems -- Life cycle assessment (LCA) of fungal-based biofuel production systems -- Thermodynamics aspects of fungal-based biofuel production systems -- Modeling and optimization to enhance fungal-based biofuel production -- Index.
    Abstract: Due to the huge quantity and diverse nature of their metabolic pathways, fungi have great potential to be used for the production of different biofuels such as bioethanol, biobutanol, and biodiesel. This book presents recent advances, as well as challenges and promises, of fungal applications in biofuel production, subsequently discussing plant pathogenic fungi for bioethanol and biodiesel production, including their mechanisms of action. Additionally, this book reviews biofuel production using plant endophytic fungi, wood-rotting fungi, fungal biocontrol agents, and gut fungi, and it investigates highly efficient fungi for biofuel production and process design in fungal-based biofuel production systems. Finally, life cycle assessment of fungal-based biofuel production systems are discussed in this volume.
    Type of Medium: Online Resource
    Pages: XI, 233 p. 35 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030444884
    Series Statement: Fungal Biology,
    DDC: 579.5
    Language: English
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    Keywords: Animal migration. ; Conservation biology. ; Ecology . ; Urban ecology (Biology). ; Animal Migration. ; Conservation Biology. ; Urban Ecology.
    Description / Table of Contents: Preface -- Part 1. Introduction to 'Problematic Wildlife II'. Problematic species are increasing, in a world that is constantly changing -- Chapter 1. The need and relevance of the book. Problematic Wildlife and the Modern World -- Part 2. From direct danger to humans to negative impact on human activities -- Chapter 2. Large Felid Predators and ‘Man-eaters’: Can we successfully balance conservation of endangered apex predators with the safety and needs of rapidly expanding human populations? -- Chapter 3. A large carnivore among people and livestock: the common leopard -- Chapter 4. Recent changes in wolf habitat occupancy and feeding habits in Italy: implications for conservation and reducing conflict with humans -- Part 3. Urban wildlife conflicts are an emerging problem -- Chapter 5. ‘Good’ and ‘bad’ urban wildlife -- Chapter 6. Wildlife and traffic – an inevitable but not unsolvable problem? -- Chapter 7. The colonization of the Western Yellow-legged Gull (Larus michahellis) in an Italian city: evolution and management of the phenomenon -- Part 4. Hunting and eco-tourism: possible mechanisms for conservation and coexistence? -- Chapter 8. How hunting and wildlife conservation can coexist. Review and case studies -- Chapter 9. What do we know about wild boar in Iberia? -- Chapter 10. Travelling in a fragile world: The value of Ecotourism -- Part 5. Species extinction -- Chapter 11. Assessing presence, decline and extinction for the conservation of difficult-to-observe species -- Chapter 12. Extinct or perhaps surviving relict populations of big cats. Their controversial stories and implications for conservation -- Part 6. Zoos, Conservation, Animal Rights -- Chapter 13. Alternative facts and alternative views: Scientists, managers, and animal rights activists -- Chapter 14. Zoos and conservation in the Anthropocene: opportunities and problems -- Chapter 15. Problematic Animals in the Zoo: the issue of charismatic megafauna -- Chapter 16. Cryptic problematic species and troublesome taxonomists: A tale of the Apennine bear and the Nile white rhinoceros -- Chapter 17. Communication and wildlife conservation (grey wolf and brown bear in Italy) -- Part 7. Humans and Herpetofauna -- Chapter 18. Snakes, snakebites, and humans -- Chapter 19. Giant Snake-Human Relationships -- Chapter 20. Risk assessment model for brown treesnake introduction into the continental United States -- Chapter 21. The Asian toad (Duttaphrynus melanostictus) in Madagascar: A report of an ongoing invasion -- Index.
    Abstract: In a world where habitats are constantly changing and the impact of anthropization on the environment is increasingly intense, interactions between human and wildlife are becoming more and more complex. Some species pose problems for human activities while many others need to be helped in order to continue to exist. This book follows the first volume called 'Problematic Wildlife', edited by F.M. Angelici and published by Springer in 2016, which has had considerable success with readers and critics. The volume includes 21 chapters divided into 7 parts devoted specific topics which are approached in a multidisciplinary way. There are both review chapters and specific cases, always bearing in mind the interest for an international audience. The book can be useful both for scientists, wildlife specialists, conservationists, zoologists, ecologists, university students, nature managers, and for those who live in contact with wildlife and its problems, such as farmers, shepherds, hunters, urban planners, and staff of parks and nature reserves. Its ultimate goal is to offer scientific and pragmatic approaches to manage each categories of problematic species.
    Type of Medium: Online Resource
    Pages: XIV, 649 p. 106 illus., 78 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030423353
    DDC: 591.568
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Nanotechnology. ; Botanical chemistry. ; Plant physiology. ; Plant biotechnology. ; Plants Development. ; Agriculture. ; Nanotechnology. ; Plant Biochemistry. ; Plant Physiology. ; Plant Biotechnology. ; Plant Development.
    Description / Table of Contents: 1. Nanotechnology: A breakthrough in Agronomy -- 2. Nanotechnology and Plant Tissue Culture -- 3. Nanotechnology and abiotic stresses -- 4. Myconanoparticles in agriculture -- 5. Nanotechnology in pest management -- 6. DNA nanobiotechnology and plant breeding -- 7. Nanotechnology and Plant Disease Diagnosis and Management -- 8. Nanofertilizers -- 9. Nanotechnology and waste water treatment -- 10. Applications of nano-biosensors in agriculture -- 11. Nanomaterials and agriwaste -- 12. Prospects and constraints.
    Abstract: In this age of population explosion and depleting natural resources, this book offers new techniques to produce more from agricultural crops at a lower cost. The field of agronomy addresses this issue and interacts with the fields of agriculture, botany, and economics. Nanotechnology and nanoparticles play a role in agronomy. This book joins techniques from both fields into once comprehensive volume. Students of agriculture, physics, nanotechnology, and plant sciences will benefit equally from this work.
    Type of Medium: Online Resource
    Pages: IX, 221 p. 40 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030412753
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    New York, NY :Springer US :
    Keywords: Cytology. ; Cancer. ; Medicine Research. ; Biology Research. ; Cell Biology. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: Introduction to genes, oncogenes, and anti-oncogenes -- Introduction to free radicals (including nitric oxide), antioxidants, lipid peroxidation and their effects on cell proliferation -- Immune system, inflammation and essential fatty acids and their metabolites in cancer -- PUFAs and their metabolites in carcinogenesis -- Molecular mechanism of anti-cancer action of PUFAs with particular reference to GLA in glioma -- Bioactive lipids (BAL)-based therapeutic approach to cancer that enhances anti-tumor action and ameliorates cytokine release syndrome of immune check point inhibitors -- A new therapeutic strategy to treat cancer based on bioactive lipids (BAL) -- Index.
    Abstract: This book discusses the role of genes, oncogenes, anti-oncogenes, free radicals, PUFAs, anti-oxidants, lipid peroxidation process, telomere, and angiogenesis on the origin of cancer, cell proliferation, and cancer in general. It includes a broad introduction to cancer cells; genes, oncogenes, and anti-oncogenes; and free radicals. In later chapters, it discusses in depth the relationship among free radicals, lipid peroxidation and anti-oxidants in cell proliferation. It also discusses aerobic and anaerobic metabolism and their relationship to cancer, as well as the Warburg effect and its potential in the development of new targets for cancer management. Based on these and other evidences, Molecular Biochemical Aspects of Cancer introduces a novel concept that suggests that selective enhancement of free radical generation in tumor cells could form a strategy to induce apoptosis of cancer cells employing bioactive lipids. It presents a new method of treatment of cancer using in vitro, in vivo and clinical data. This book will interest oncologists, scientists, molecular biologists, life scientists.
    Type of Medium: Online Resource
    Pages: XIII, 254 p. 58 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9781071607411
    DDC: 571.6
    Language: English
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    Keywords: Microbial ecology. ; Biotic communities. ; Astrobiology. ; Conservation biology. ; Ecology . ; Environmental education. ; Microbial Ecology. ; Ecosystems. ; Astrobiology. ; Conservation Biology. ; Environmental and Sustainability Education.
    Description / Table of Contents: Section I - General considerations -- Chap 1 - Introduction Maria Eugenia Farias (LIMLA, Argentina) -- Chap 2 - Origin and evolution of the central Andes: deserts, salars lakes and volcanoes R.Alonso (U. Nacional de Salta, Argentina) and W. Rojas (Eramine Sudámerica S.A., Argentina) -- Chap 3 - Modern microbilies mats and endovaporite system in Andean lakes: a general approach Maria Eugenia Farias (LIMLA, Argentina) -- Section II - Preandean and andean atacam desert: life at limits -- Chap 4 - Desert polyextreme environment and lithobiontic habitats J. Wierzchos, C. Ascaso, O. Artieda and M.C. Casero (Museo Nacional de Ciencias Naturales, Spain) -- Chap 5 - Desert microbiology J. Di Ruggiero (Johns Hopkins University, USA) and M.C. Casero (Museo Nacional de Ciencias Naturales, Spain) -- Chap 6 - Desert biosignatures P. Vitek (The Czech Academy of Sciences, Czech Republic) and J. Wierzchos (Museo Nacional de Ciencias Naturales, Spain) -- Chap 7 - Microbial characterization of Andean Vega's soil C. Belfiore, M.E. Farias (LIMLA, Argentina) and M. Contreras (Centro de Ecología Aplicada, Chile) -- Section III - Life in Andean Volcanoes and Fumaroles -- Chap 8 - Limits to microbial life at the altitudinal and dry extremes for life on Earth at Llullaillaco and Socompa Volcacones S. Scmidt and P. Sowell (University of Colorado, USA) -- Chap 9 - The biogeochemistry of microorganisms in the geothermal features of El Tatio Geyser Field, Chile K.D. Myers (Columbia University, USA), A.S. Angel (University of Tennessee, USA) and P.C. Bennett (The University of Texas at Austin, USA) -- Chap 10 - The unique holoarchea dominated biofilms associated Diamante Lake inside Galan Volcanoes Microbialites N. Rascova (Aix Marseille Université, France) and M.E. Farias (LIMLA, Argentina) -- Section IV - Endoevaporites and Mats in Salars and Wetlands -- Chap 11 - Endoevaporites dominated by Arquea at Laguna Tebenquiche M.C. Rasuk (LIMLA, Argentina), Pieter V. (University of Connecticut, USA), A.B. Fernández (University of Sevilla, Spain) and M.E. Farias (LIMLA, Argentina) -- Chap 12 - Rare microbial biosphere in Salar de Huasco: hyperdiversity in polyextreme aquatic ecosystem C. Dorador, N. Miranda, V. Ávalos (Universidad de Antofagasta, Chile), V. Molina (Universidad de Playa Ancha, Chile) and M. Hengst (Universidad Católica del Norte, Chile) -- Chap 13 - Microbiome of evaporites and microbial mats in the Salar de Llamara, Atacama desert M. Rasuk and M.E. Farias (LIMLA, Argentina) -- Chap 14 - Microbial diversity in athalassohaline Argentinean salterns M.R. Mora-Ruiz and R. Rosselló-Móra (Mediterranean Institute for Advanced Studies, Spain) -- Section V - Microbialites at lakes -- Chap 15 - Physicochemical and microbiological processes in carbonate precipitation in hypersaline lakes: the laguna Negra case F.J. Gomez (Centro de Investigaciones en Ciencias de la Terra, Argentina), L.C. Kah (University of Tennessee, USA), C. Mlewski, F.J. Boidi (Centro de Investigaciones en Ciencias de la Terra, Argentina) and E. Gerard (Université Paris Diderot, France) -- Chap 16 - Microbialites Laguna Socompa V. Albarracin and M.E. Farias (LIMLA, Argentina) -- Chap 17 - Microbialites oncolites and mats at Laguna La Brava P. Visscher (University of Connecticut, USA), M. Contreras (Centro de Ecologia Aplicada, Chile) and M.E. Farias (LIMLA, Argentina) -- Chap 18 - Modern microbiolites of Pozo Bravo lake, Salas de Antofalla, Antofagasta de la Sierra, Catamarca A.I. Lencina, M.N. Soria (PROIMI, Argentina), R. Palma (Universidad de Buenos Aires, Argentina) and M.E. Farias (LIMLA, Argentina) -- Section VI - Extremolites: microbes surviving in Andean microbial ecosystems -- Chap 19 - Light sensing and mechanisms of adaptation to high solar irradiation V.H. Albarracín, M. Gorriti, L. Portero, F. Zannier (PROIMI, Argentina), W. Gärtner (Max Planck Institute, Germany) and M.E. Farias (LIMLA, Argentina) -- Chap 20 - Linear megaplasmids spreading the Andean Resistome M.F. Perez and J.R. Dib (LIMLA, Argentina) -- Chap 21 - Arsenic: Not as bad as it sounds Visscher (University of Connecticut, USA), Gallagher, Contreras (Centro de Ecologia Aplicada, Chile), Farias (Universidad Nacional de La Plata, Argentina), Philippot (Univesité Paris Diderot, France), Sancho-Tomas and Somogyi (Synchroton Soleil, France) -- Section VII - Prospecting and protecting singular ecosystems -- Chap 22 - Conservation of extremophile communities in complex ecosystems M. Contreras (Centro de Ecologia Aplicada, Chile) -- Chap 23 - Integral prospection of Andean Microbial Ecosystem Project M.E Farias (LIMLA, Argentina) -- Index -- .
    Abstract: The Central Andean Altiplane represents a unique extreme environment due to its high altitude, closed basins that modulate the salt pans and saline wetlands surrounded by deserts, as well as the considerable influence of volcanic activity. UV radiation, arsenic content, high salinity, alkalinity and low dissolved oxygen levels, together with extreme daily temperature fluctuations and oligotrophic conditions, shape an environment that resembles the early Earth and, even more, extraterrestrial conditions. By developing simple biofilms stratified microbial mats or complex microbialites, extreme microbial ecosystems, colonize and thrived in different environments like salt flats, wetlands, lakes volcano vents, geysers and deserts. This book presents our current understanding of these amazing ecosystems, providing a basis for their protection and sustainable utilization. The main audience for this book included researchers and graduate students as well as professionals working in the government, mining industry and similar activities.
    Type of Medium: Online Resource
    Pages: XXIV, 292 p. 62 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030361921
    DDC: 579.17
    Language: English
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  • 65
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Evolution (Biology). ; Microbial genetics. ; Plant genetics. ; Genetics. ; Evolutionary Biology. ; Microbial Genetics. ; Plant Genetics. ; Genetics and Genomics.
    Description / Table of Contents: Genetic and morphological differentiation of common toads in the Alps and the Apennines -- Molecular phenotypes as key intermediates in mapping genotypes to fitness -- A practical guide to orthology resources -- Protein recoding through RNA editing: detection, function, evolution -- Most successful mammals in the making: a review of the Paleocene Glires -- Continuous spectrum of lifestyles of plant-associated fungi under fluctuating environments: What genetic components determine the lifestyle transition? -- Genome evolution of asexual organisms and the paradox of sex in eukaryotes -- On the origin of life and evolution of living systems from a world of biological membranes -- Orthology: promises and challenges -- Prehistoric Stone Projectile Points and Technological Convergence -- Diversity and Evolution of RNase P -- An unusual evolutionary strategy: the origins, genetic repertoire, and implications of doubly uniparental inheritance of mitochondrial DNA in bivalves -- The evolution of the FLOWERING LOCUS T-like (FTL) genes in the goosefoot subfamily Chenopodioideae -- DDE transposon as public goods -- Evolution of milk oligosaccharides of Carnivora and Artiodactyla: significance of the ratio of oligosaccharides to lactose in milk -- Making sense of noise.
    Abstract: This book includes 16 selected contributions presented at the 23rd Evolutionary Biology Meeting, which took place in Marseille in September 2019. The annual Evolutionary Biology Meetings in Marseille serve to gather leading evolutionary biologists and other scientists using evolutionary biology concepts, e.g. for medical research. The aim of these meetings is to promote the exchange of ideas to encourage interdisciplinary collaborations. Offering an up-to-date overview of recent findings in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students.
    Type of Medium: Online Resource
    Pages: VIII, 391 p. 85 illus., 73 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030572464
    DDC: 576.8
    Language: English
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  • 66
    Keywords: Neurosciences. ; Pharmacology. ; Anesthesiology. ; Neuroscience. ; Pharmacology. ; Anesthesiology.
    Description / Table of Contents: Chapter 1. Analgosedation -- Chapter 2. Inhalational Anesthetics -- Chapter 3. Intravenous Anesthetic Agents -- Chapter 4. Local Anesthetics -- Chapter 5. Neuromuscular Blocking Drugs (nmbds) -- Chapter 6. Reversal Agents and Antagonists -- Chapter 7. Anticholinergics -- Chapter 8. Anti-epileptic Drugs (aeds) -- Chapter 9. Osmotherapy -- Chapter 10. Antibiotics -- Chapter 11. Anti-viral -- Chapter 12. Antifungal -- Chapter 13. Anticoagulants and Antiplatelets -- Chapter 14. Glucocorticoids -- Chapter 15. Antihypertensives -- Chapter 16. Vasopressors -- Chapter17. Antipsychotics -- Chapter 18. Miscellaneous drugs. .
    Abstract: The pharmacodynamics and pharmacokinetics of several drugs is expected to be known to clinicians and researchers at all times. With advances in sciences and development of newer drugs very frequently, it is very important to keep your knowledge updated at all times. This title is a quick guide to researchers and clinicians for a quick reference. The title is also a vital resource for all streams of neurosciences (neuroanesthesia and neurointensive care) and is much different from a conventional pharmacology titles, being more reader friendly and to the point facilitated with numerous flowcharts and algorithms with each chapter being prepared in a standard structured manner.
    Type of Medium: Online Resource
    Pages: VII, 1074 p. 331 illus., 108 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811535918
    DDC: 612.8
    Language: English
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  • 67
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Food science. ; Nutrition   . ; Bioinformatics. ; Biotechnology. ; Food Science. ; Nutrition. ; Computational and Systems Biology. ; Biotechnology.
    Description / Table of Contents: Soybean (Glycine max) -- Rapeseed/Canola (Brassica napus) -- Cottonseed (Gossypium hirsutum),- Ground nut (Arachis hypogaea) -- Sunflower (Helianthus annuus) seed -- Palm /Palm kernel (Elaeis guineensis) -- Coconut (Cocos nucifera),- Mustard (Brassica nigra) seed,- Olive (Olea europaea),- Flaxseed (Linum usitatissimum), - Chia seed (Salvia hispanica),- Sesame (Sesamum indicum) seed -- Nigella (Nigella sativa) seed,- Borage (Borago officinalis) seed,- Hempseed (Cannabis sativa),- Rice (Oryza sativa) bran,- Safflower (Carthamus tinctorius) -- Camelina (Camelina sativa) seed,- Pumpkin (Cucurbita pepo) seed,- Cumin (Cuminum cyminum) seed.
    Abstract: Oilseeds offer a plethora of opportunities for the food and feed industry, thanks to their high oil and protein content . Their phytonutrients and functional components have attracted the interest of researchers, leading to the development of functional foods. This book gathers the latest scientific information on the nutrients, phytonutrients and health benefits as well as the adverse effects of consuming various conventional and non-conventional oilseeds. In addition, each chapter includes a section comprehensively explaining the use of oilseeds in functional bakery, dairy, and other food products. Given its scope, the book is a valuable resource for students, researchers, nutritionists, food scientists and technologists, and for anyone involved in product development based on oilseed and its components.
    Type of Medium: Online Resource
    Pages: IX, 517 p. 42 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811541940
    DDC: 641.3
    Language: English
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  • 68
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Biotechnology. ; Biology Technique. ; Protein Biochemistry. ; Chemical Bioengineering. ; Biological Techniques.
    Description / Table of Contents: Literature Search -- Sequence Analysis -- Structural Analysis -- Protein Expression Hosts and Expression Plasmids -- Gene Cloning -- Protein Expression -- Assay -- Gene Mutagenesis -- High-Throughput Screening (HTS) -- Protein Variants Analysis and Characterization -- Continuing from Protein Variants -- Employability.
    Abstract: This textbook introduces readers in an accessible and engaging way to the nuts and bolts of protein expression and engineering. Various case studies illustrate each step from the early sequence searches in online databases over plasmid design and molecular cloning techniques to protein purification and characterization. Furthermore, readers are provided with practical tips to successfully pursue a career as a protein engineer. With protein engineering being a fundamental technique in almost all molecular biology labs, the book targets advanced undergraduates and graduate students working in molecular biology, biotechnology and related scientific fields.
    Type of Medium: Online Resource
    Pages: XV, 202 p. 91 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030568986
    Series Statement: Learning Materials in Biosciences,
    DDC: 572.6
    Language: English
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  • 69
    Keywords: Freshwater ecology. ; Marine ecology. ; Conservation biology. ; Ecology . ; Biodiversity. ; Animal migration. ; Freshwater and Marine Ecology. ; Conservation Biology. ; Biodiversity. ; Animal Migration.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. European pearl mussel: background information and literature review -- Chapter 3. Materials and methods -- Chapter 4. Results -- Chapter 5. Discussion -- Chapter 6. Conclusions.
    Abstract: The monograph focuses on the European freshwater pearl mussel Margaritifera margaritifera, which is an endangered bivalve species. Most of its populations in the Russian section of the Baltic Sea basin had never been studied, although they were known in the past to the pearl fishers. “Rediscovery” included search for the previously unknown populations, revealing the facts of population extinctions, analysis of negative impacts, elaboration of conservation measures, and revealing of regularities in distribution. Patterns of land use and river management were analyzed. The procedure of “rediscovery” was applied for other animal species of Northwest Russia, which are threatened on a global scale – thick-shelled mussel, Unio crassus; curlew Numenius arquata; black-tailed godwit, Limosa limosa; Northern Lapwing, Vanellus vanellus; European mink, Mustela lutreola; pond bat, Myotis dasycneme; Atlantic sturgeon, Acipenser sturio; and broad-clawed crayfish, Astacus astacus. The methods and principles of conservation studies were discussed. The obtained data were analyzed with respect to current global change of biosphere. The book will appeal to specialists dealing with conservation studies and activities such as red lists, river protection, and conservation of endangered species. Moreover, a part of the book represents an interest for biogerontology as it presents discredit of the popular concept on “negligible senescence.” The data on distribution of some animals in Russia will be interesting in terms of zoology and biogeography, as they are not yet sufficiently represented in the international editions. The book can be used as supplemental reading for courses in biological invasions, ecology and conservation, and biodiversity. The work also contains chapters on global processes (deforestation, desertification, river degradation) and can therefore also be used for general courses in environmental sciences.
    Type of Medium: Online Resource
    Pages: XI, 246 p. 88 illus., 87 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030662554
    DDC: 577.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant biotechnology. ; Plant genetics. ; Agriculture. ; Plant Biotechnology. ; Plant Genetics. ; Agriculture.
    Description / Table of Contents: Economic/Academic importance -- Background of the sequencing initiatives -- Molecular mapping and cloning of genes and QTLs -- Physical mapping of the genome -- Whole genome sequencing and assembling -- Structure and composition of centromere in Brassica genome -- Genome annotation -- Gene loss -- Alternative splicing -- Gene conversion -- Gene family differentiation in Brassica species -- Glucosinates -- R genes variations after triplication -- Structural & functional genomic resources developed -- Impact on plant breeding and crop improvement -- Data bases -- Future prospects.
    Abstract: This book presents comprehensive information on genetics, genomics and breeding in Brassica oleracea, an agriculturally important species that includes popular vegetable crops such as cabbage, cauliflower, broccoli, Brussels sprouts, kale, collard greens, savoy, kohlrabi, and gai lan. The content spans whole genome sequencing, assembly and gene annotation for this global vegetable species, along with molecular mapping and cloning of genes, physical genome mapping and analyses of the structure and composition of centromeres in the B. oleracea genome. The book also elaborates on asymmetrical genome evolution and transposable elements in the B. oleracea describes gene family differentiation in comparison to other Brassica species and structural and functional genomic resources and data bases developed for B. oleracea. Useful discussions on the impact of genome sequencing on genetic improvement in the species are also included.
    Type of Medium: Online Resource
    Pages: XXIV, 145 p. 33 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030310059
    Series Statement: Compendium of Plant Genomes,
    DDC: 631.52
    Language: English
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  • 71
    Keywords: Human physiology. ; Medicine Research. ; Biology Research. ; Proteins . ; Biological transport. ; Cell membranes. ; Human Physiology. ; Biomedical Research. ; Protein Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells -- 2. Na+-K+-2Cl- Cotransporter -- 3. Thiazide-sensitive NaCl Cotransporter -- 4. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia -- 5. Na+/H+ Exchangers in Epithelia -- 6. Sugar Transport Across Epithelia -- 7. Amino Acid Transporters of Epithelia -- 8. Structure-Dynamic and Regulatory Specificities of Epithelial Na+/Ca2+ Exchangers (NCX) -- 9. Urea Transporters in Health and Disease -- 10. H,K-ATPases in Epithelia -- 11. Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells -- 12. Properties, Structure and Function of the Solute Carrier 26 Family of Anion Transporters -- 13. ClC-2 Chloride Channels -- 14. The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology -- 15. CFTR and Cystic Fibrosis: A Need for Personalized Medicine -- 16. Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator -- 17. TMEM16 Proteins (Anoctamins) in Epithelia -- 18. Epithelial Sodium Channels (ENaC) -- 19. ROMK and Bartter Syndrome Type 2 -- 20. Inwardly-rectifying K+ channel 4.1 regulates renal K+ excretion in the aldosterone-sensitive distal nephron -- 21. Small-molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels -- 22. KCa3.1 in Epithelia -- 23. BK Channels in Epithelia -- 24. Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ channels -- 25. KCNE regulation of KCNQ channels -- 26. Orai Channels -- 27. Trp Channels in Renal Epithelia -- 28. P2X receptors in Epithelia -- 29. The Polycystins and Polycystic Kidney Disease -- 30. Renal Aquaporins in Health and Disease.
    Abstract: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.
    Type of Medium: Online Resource
    Pages: XXI, 1244 p. 256 illus., 203 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030554545
    Series Statement: Physiology in Health and Disease,
    DDC: 612
    Language: English
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  • 72
    Keywords: Microbiology. ; Renewable energy sources. ; Microbiology. ; Renewable Energy.
    Description / Table of Contents: Chapter 1. Advancements in Biofuel Production -- Chapter 2. Bionenergy: Sustainable Renewable Energy -- Chapter 3. Biofuel from Microalgae -- Chapter 4. Waste to bioenergy: Recent Technologies -- Chapter 5. Bioenergy from Agricultural Wastes -- Chapter 6. Bio-Processing: Biomass to Commercial Alcohol -- Chapter 7. Hydrogen Production by Utilizing Bio-Processing Techniques -- Chapter 8. Bacterial Hydrogen Production: Prospects and Challenges -- Chapter 9. Bioethanol Production from Biodiesel Derived Glycerol – A Case Study -- Chapter 10. Advancement on biomass classification, analytical methods for characterization and its economic importance.
    Abstract: This volume is fourth part of the five-part set on bioenergy research. This volume covers biomass to bioenergy production concept. The book is focused on the possible and versatile biomass options available for the generation of bioenergy. Additionally, the book also explores different types of biomass for bioenergy generation at a commercial level. Further, the book elaborates on different kind of cellulose and sugar rich waste which can also be utilized for bioenergy production. It covers other relevant issues such as recent technological advancement in biomass to bioenergy conversion, waste management in the context of biomass to biofuels production technologies, green methods of energy production, alternates of fossil fuels in the near future. It also explores biomass waste valorization, utilizing microbial processes in bioenergy production. This is a useful reading material for students, researchers, industry and policy experts. Other four volumes of this set explore basic concepts, latest progress, commercial opportunities and integrated solution for bioenergy concerns. .
    Type of Medium: Online Resource
    Pages: XI, 272 p. 35 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618628
    Series Statement: Clean Energy Production Technologies,
    DDC: 579
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Hematology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Hematology.
    Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.
    Abstract: It has been 10 years since the first edition of ‘Essentials of Tissue Banking’ has been published. There is still relatively little published on the technical and scientific principles on routine tissue and cell banking based on scientific principles. The 1st edition was very successful and, after a 10 year gap, there is a need of an update and an expansion of the book’s remit. The format of the book follows that of the previous edition- split into 5 sections. Management of donors and the banking of common tissues and cells; Principles of storage and processing of tissues and cells; Ensuring the safety of the products by testing the donor, the tissues and the environment, supported by a quality system and an IT infrastructure- all working within the constraints of current regulatory and ethical environments. This edition however provides a significant update. Many the chapters have been completely rewritten by different experts. Like the 1st edition, they were given a free hand in the way they wrote their chapter, with a guideline that they had to be concise, clear and up to date. The authors were also asked to provide the scientific and technical basis that provides the rationale of the processes they describe. Also, the scope of the book has been somewhat extended. In view of the fact that many cellular therapies are now routinely practiced, 2 new chapters have been added: one on the banking of haematopoietic stem cells and one on human embryonic stem cells. They have been deliberately chosen to illustrate the extreme spectrum of cellular therapies from one of the simplest to one of the most complex. The intention of the book has remained the same: to cover and update banking of current practices in essential tissue and cell banking. It is therefore hoped that by keeping the book as concise and up to date as possible, it will find a place on the shelves of many tissue establishments.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 48 illus., 28 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030716219
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical microbiology. ; Pharmacology. ; Pediatrics. ; Medical Microbiology. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Part 1 General Vaccinology -- 1 Expected and Unexpected Effects of Vaccination -- 2 How Vaccinating People Can Also Protect Others -- 3 Childhood and Adolescent Immunization Programs in Europe -- 4 Vaccine Hesitancy, Acceptance, and Demand -- 5 Adjuvants in Pediatric Vaccines -- 6 Maternal Immunization -- 7 Neonatal Immunization -- Part 2 Viral Vaccines and Vaccinations -- 8 Poliovirus Vaccines -- 9 Measles–Mumps–Rubella Vaccine -- 10 Varicella Vaccines -- 11 Rotavirus Vaccine -- 12 Hepatitis A Vaccines -- 13 Hepatitis B Vaccines -- 14 Influenza Vaccines -- 15 Human Papillomavirus Vaccines -- 16 Tick-Borne Encephalitis Vaccines -- Part 3 Bacterial Vaccines and Vaccination -- 17 Tuberculosis Vaccines -- 18 Pertussis Vaccines -- 19 Haemophilus influenzae type b (Hib) Vaccines -- 20 Pediatric Combination Vaccines -- 21 Pneumococcal Vaccines -- 22 Meningococcal Vaccines -- 23 Pediatric Vaccines for Travel Outside Europe -- Part 4 New Vaccines in Pipeline Development -- 24 GBS and CMV Vaccines in Pipeline Development -- 25 Norovirus Vaccines in Pipeline Development -- 26 RSV Vaccines and Monoclonal Antibodies in Development -- 27 COVID-19 in Children and COVID-19 Vaccines -- 28 Registration of Vaccines, Safety Follow-Up, and Pediatric Investigation Plan.
    Abstract: This second fully updated and extended edition of the textbook serves as a highly readable guide on latest developments in vaccine development and vaccination programs in infants, children and adolescents from a European perspective. The first part of the book introduces to general vaccinology, immunization programs and formulation, effects and unwanted effects of vaccines. The second and third part provide an overview on current viral and bacterial vaccines. The fourth and last part of this book discusses new vaccines in the pipeline and gives insights into safety and regulatory matters. This second edition is extended by a whole new chapter on COVID-19 vaccines. This book serves as a reference textbook in the field and helps to standardize the information on vaccines and immunization programs in the WHO European Region.
    Type of Medium: Online Resource
    Pages: XIII, 319 p. 66 illus., 63 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030771737
    DDC: 616.9041
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Freshwater ecology. ; Marine ecology. ; Evolution (Biology). ; Biodiversity. ; Animal culture. ; Plant genetics. ; Climatology. ; Freshwater and Marine Ecology. ; Evolutionary Biology. ; Biodiversity. ; Animal Science. ; Plant Genetics. ; Climate Sciences.
    Description / Table of Contents: Part I: Introduction -- Marine Population Genomics: Challenges and Opportunities -- Part II: Marine Microbes -- Part III: Genetic Diversity, Population Structure, and Biogeography -- Population Genomics of Marine Zooplankton -- Population Genomics of Early-Splitting Lineages of Metazoans -- Population Genomics and Biogeography of the Northern Acorn Barnacle (Semibalanus balanoides) Using Pooled Sequencing Approaches -- Part IV: Seascape Genomics -- Seascape Genomics: Contextualizing Adaptive and Neutral Genomic Variation in the Ocean Environment -- Part V: Adaptation, Acclimation, and Speciation -- Clinal Adaptation in the Marine Environment -- The Population Genomics of Parallel Adaptation: Lessons from Threespine Stickleback -- Mechanisms of Adaptive Divergence and Speciation in Littorina saxatilis: Integrating Knowledge from Ecology and Genetics with New Data Emerging from Genomic Studies -- Ecological Speciation in Corals -- Environmental Epigenomics and Its Applications in Marine Organisms -- Part VI: Protection, Conservation, and Management of Marine Organisms -- Marine Invasion Genomics: Revealing Ecological and Evolutionary Consequences of Biological Invasions -- Population Genomics Applied to Fishery Management and Conservation -- Marine Conservation and Marine Protected Areas -- Index.
    Abstract: Population genomics has provided unprecedented opportunities to unravel the mysteries of marine organisms in the oceans' depths. The world's oceans, which make up 70% of our planet, encompass diverse habitats and host numerous unexplored populations and species. Population genomics studies of marine organisms are rapidly emerging and have the potential to transform our understanding of marine populations, species, and ecosystems, providing insights into how these organisms are evolving and how they respond to different stimuli and environments. This knowledge is critical for understanding the fundamental aspects of marine life, how marine organisms will respond to environmental changes, and how we can better protect and preserve marine biodiversity and resources. This book brings together leading experts in the field to address critical aspects of fundamental and applied research in marine species and share their research and insights crucial for understanding marine ecosystem diversity and function. It also discusses the challenges, opportunities and future perspectives of marine population genomics. .
    Type of Medium: Online Resource
    Pages: XVI, 456 p. 75 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030379360
    Series Statement: Population Genomics,
    DDC: 577.6
    Language: English
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  • 76
    Keywords: Biotechnology. ; Food science. ; Microbiology. ; Biotechnology. ; Food Science. ; Microbiology.
    Description / Table of Contents: Part 1. Microalgae in Food Product Development -- Chapter 1. Food and high value products from microalgae: market opportunities and challenges -- Chapter 2. Algae as a mainstream food ingredient: demand and supply perspective -- Chapter 3. Microalgae pigments: a source of natural food color -- Chapter 4. Algal biotechnology: a sustainable route for omega-3 fatty acids and carotenoids production -- Part 2. Microalgae in Health Product Development -- Chapter 5. Microalgae in human health and medicine -- Chapter 6. Astaxanthin production from microalgae -- Chapter 7. Microalgae nutraceuticals: the role of lutein in human health -- Part 3. Microalgae for Cosmetic Formulations -- Chapter 8. Algae and Aging -- Chapter 9. Extracts and bioactives from microalgae (sensu stricto): opportunities and challenges for a new generation of cosmetics -- Part 4. Other High Value Application -- Chapter 10. Microalgae as Vaccine Delivery System to Aquatic Organisms -- Chapter 11. Microalgal as a sustainable source for bioplastic -- Chapter 12. Microalgae as biofertillizer in modern agriculture -- Part 5. Biomass Production -- Chapter 13. Microalgae biomass production, drying and storage -- Chapter 14. Microalgal carbohydrate and proteins: synthesis, extraction, application and challenges -- Chapter 15. Pretreatment and lipid extraction from wet microalgae: Challenges, potential and application for industrial scale application.
    Abstract: "Microalgae Biotechnology for Food, Health and High Value Products” presents the latest technological innovations in microalgae production, market status of algal biomass-based products, and future prospects for microalgal applications. It provides stimulating overviews from different perspectives of application that demonstrate how rapidly the commercial production of microalgae-based food, health and high value products is advancing. It also addresses a range of open questions and challenges in this field. The book highlights the latest advances of interest to those already working in the field, while providing a comprehensive overview for those readers just beginning to learn about the promise of microalgae as a sustainable source of both specialty and commercial products. It offers a valuable asset for commercial algae producers, algae product developers, scientific researchers and students who are dedicated to the advancement of microalgae biotechnology for applications in health, diet, nutrition, cosmetics, biomaterials etc. .
    Type of Medium: Online Resource
    Pages: X, 483 p. 91 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811501692
    DDC: 660.6
    Language: English
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  • 77
    Keywords: Plant physiology. ; Botanical chemistry. ; Plants Development. ; Plant diseases. ; Plant Physiology. ; Plant Biochemistry. ; Plant Development. ; Plant Pathology.
    Description / Table of Contents: Studying miRNAs in plants -- Regulation of plant miRNA biogenesis -- Technologies to address plant miRNA functions -- Strategies and resources for the identification of microRNAs in non-model plants -- miRNAs in the formation of epigenetic memory in plants -- miRNAs in plant development -- miRNA regulation of fruit development -- miRNAs in plant embryogenesis -- Emerging of microRNAs as key regulators in plant secondary metabolism -- miRNAs in vascular development -- miRNAs in plant abiotic and biotic stresses -- Regulation of high-temperature stress response by small RNAs -- Role of microRNAs in plant-fungus interactions -- Plant miRNAs regulate innate immunity through diverse mechanisms.
    Abstract: This book summarizes the latest findings on the functions of microRNAs in the regulation of plant development and responses to the surrounding environment. MicroRNAs are an important class of molecules that can be found in diverse groups of organisms, including plants and animals, and the investigation of their roles is a highly dynamic and “hot” research topic. The respective chapters address four main aspects, namely: microRNA investigation and annotation, the regulatory roles of microRNAs in various developmental processes, in response to abiotic factors, and in the context of biotic stress response regulation. Systematically reviewing the most important findings in this field, the book offers an essential guide for undergraduate and graduate students, teachers, and plant science researchers. Due to the potential applications of microRNAs in crop breeding and plant protection, it also represents a valuable resource for scientists in academia and the private sector alike. .
    Type of Medium: Online Resource
    Pages: XXI, 238 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357726
    Series Statement: Concepts and Strategies in Plant Sciences,
    DDC: 571.2
    Language: English
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  • 78
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Stem cells. ; Regenerative medicine. ; Medical genetics. ; Biotechnology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Clinical Genetics. ; Chemical Bioengineering.
    Description / Table of Contents: Application of iPSC to modelling of respiratory diseases -- Gene editing in human pluripotent stem cells: recent advances for clinical therapies -- Vascular wall as source of stem cells able to differentiate into endothelial cells -- Physiological and therapeutic roles of neuropeptide Y on biological functions -- Rho signaling-directed YAP/TAZ regulation encourages 3D spheroid colony formation and boosts plasticity of Parthenogenetic Stem Cells -- Transamniotic Stem Cell Therapy -- Regenerative medicine: Injectable cell-based therapeutics and approved products -- Stem Cell Therapy for Hepatocellular Carcinoma: Future Perspectives -- Potential of tribological properties of metalnanomaterials in biomedical applications -- The impact of the low frequency of the electromagnetic field on human.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the seventh volume of a continuing series Chapter “Application of iPSC to Modelling of Respiratory Diseases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 153 p. 30 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030378455
    Series Statement: Cell Biology and Translational Medicine, 1237
    DDC: 571.6
    Language: English
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  • 79
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Nanotechnology. ; Cancer. ; Stem cells. ; Diseases. ; Biotechnology. ; Nanotechnology. ; Cancer Biology. ; Stem Cell Biology. ; Diseases.
    Description / Table of Contents: Chapter 1.Current Advances in Nanotechnology and Medicine -- Chapter 2. Least Explored Small Wonders: Nano-biotechnology -- Chapter 3. Modern Approaches in Nanomedicine for neuroAIDS and CNS drug delivery -- Chapter 4. Nanobiotechnology: Paving the way to personalized medicine -- Chapter 5. Nanomedicine in cancer stem cell therapy -- Chapter 6. Nanobiosensor: Current Trends and Applications -- Chapter 7. Transition Metal Oxide Nanoparticles: A New Horizon in Cancer Treatment -- Chapter 8. Nanomedicine meets microRNA expression and function in prostate cancer -- Chapter 9. Biomedical applications of Viral Nanoparticles in vaccine therapy -- Chapter 10. HIV: Biology to Nanomedicine -- Chapter 11. Current Advances in Phage Inspired Nanocarriers Based Therapy -- Chapter 12. Nanophytotherapeutic potential of Essential Oils against Candida infections -- Chapter 13. Molecular tests for the Diagnosis of Tuberculosis: Nanodiagnostics Approaches -- Chapter 14. Molecular Mechanisms of drug resistance in Mycobacterium tuberculosis: Role of nanoparticles against Multi-Drug Resistant tuberculosis (MDR-TB) -- Chapter 15. Nano-Mass spectrometry (nano-MS) based lipidomics -- Chapter 16. Techniques to understand Mycobacterial Lipids and use of Lipid Based Nanoformulations for Tuberculosis Management -- Chapter 17. Recent trends and challenges in Patches for cardiac tissue reengineering: role of Nanomaterials -- Chapter 18. Cyclic dinucleotides: Big roles of small molecules and its role in nanotechnology and medicine -- Chapter 19. Antibodies: Biology to Therapeutics and its role in nanomedicine -- Chapter 20. Nanotoxicology in Medicine -- Chapter 21. Antibody-targeted nanoparticles for cancer treatment -- Chapter 22. Nanoparticle mediated combined photothermal and photodynamic therapy -- Chapter 23. Nanotechnology based devices and its applications in medicine- Chapter 24. Opportunities in clinical translation and commercialization of nanomedicine. .
    Abstract: This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology. .
    Type of Medium: Online Resource
    Pages: XX, 517 p. 90 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813298989
    DDC: 660.6
    Language: English
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  • 80
    Keywords: Agriculture. ; Botany. ; Agriculture. ; Plant Science.
    Description / Table of Contents: Preface -- Part I: Leaves -- Chapter 1. Advances in Chicory (Cichorium intybus L.) Breeding Strategies (Laila Aldahak, Khaled F. M. Salem, Salih H. F. Al-Salim, and Jameel M. Al-Khayri) -- Chapter 2. Chinese Cabbage (Brassica rapa L. var. pekinensis) Breeding: Application of Molecular Technology (Takumi Okamoto, Xiaochun Wei, Hasan Mehraj, Mohammad Rashed Hossain, Ayasha Akter, Naomi Miyaji, Yoshinobu Takada, Jong-In Park, Ryo Fujimoto, Ill-Sup Nou, and Masao Watanabe) -- Chapter 3. Breeding Advances and Prospects in Rocket Salad (Eruca vesicaria ssp. sativa Mill.) Cultivation (Pasquale Tripodi, Paula Santos Coelho, and Carla Guijarro-Real) -- Chapter 4. Spring Onion (Allium fistulosum L.) Breeding Strategies (Fatimah Kayat, Ahmed Mahmood Ibrahim, and Arifullah Mohammed) -- Chapter 5. Water Spinach (Ipomoea aquatica Forsk.) Breeding (Moumita Gangopadhyay, Anup Kumar Das, Subhendu Bandyopadyay, and Samanwita Das) -- Chapter 6. Watercress (Nasturtium officinale R. Br.) Breeding (Mohammadreza Hassandokht, Sajad Jafari, and Raheleh Ebrahimi) -- Part II: Flowerheads and Green Pods -- Chapter 7. Advances in Cauliflower (Brassica oleracea var. botrytis L.) Breeding, with Emphasis on India (Pritam Kalia and Shrawan Singh) -- Chapter 8. Globe Artichoke (Cynara cardunculus var. scolymus L.) Breeding (Fernando López-Anido and Eugenia Martin) -- Chapter 9. Breeding Strategies of Garden Pea (Pisum sativum L.) (Amal M.E. Abdel Hamid and Khaled F.M. Salem) -- Chapter 10. Genetic Improvement of Yardlong Bean (Vigna unguiculata (L.) Walp. ssp. sesquipedalis (L.) Verdc.) (Pidigam Saidaiah, Thuraga Vishnukiran, Someswar Rao Pandravada, Natarajan Sivaraj, Adimulam Srivani, Amarapalli Geetha, Nimmarajula Srinivas, and Venkateswaran Kamala) -- Part III: Mushrooms -- Chapter 11. Enoki Mushroom (Flammulina velutipes (Curtis) Singer) Breeding (Ved P. Sharma, Anupam Barh, Rakesh Kumar Bairwa, Sudheer K. Annepu, Babita Kumari and Shwet Kamal) -- Chapter 12. Shiitake Mushroom (Lentinula edodes (Berk.) Sing.) Breeding in China (Quanju Xiang, Bilal Adil, Qiang Chen, Yunfu Gu, Xianfu Zeng, and Xinzhu Li) -- Part IV: Truffles -- Chapter 13. Desert Truffles (Terfezia spp.) Breeding (Asunción Morte, Francisco Arenas, José E. Marqués-Gálvez, Alberto Andrino, Ángel L. Guarnizo, Almudena Gutiérrez, Luis Miguel Berná, Manuela Pérez-Gilabert, Antonio Rodríguez, and Alfonso Navarro-Ródenas) -- Chapter 14. Enhancing White Truffle (Tuber magnatum Picco and T. borchii Vittad.) Cultivation through Biotechnology Innovation (Alessandra Zambonelli, Mirco Iotti, Federico Puliga, and Ian R. Hall).
    Abstract: Plant breeders and geneticists are under constant pressure to sustain and expand food production by using innovative breeding strategies and introducing minor crops, which are well adapted to marginal lands, provide a source of nutrition, and have abiotic and biotic stress tolerance, to feed an ever-increasing human population. The basic concept of this book is to examine the use of innovative methods, augmenting traditional plant breeding, towards the improvement and development of new crop varieties, under the increasingly limiting environmental and cultivation factors, to achieve sustainable agricultural production and enhanced food security. Three volumes of the book series Advances in Plant Breeding Strategies were published in 2015, 2016 and 2018, respectively: Volume 1. Breeding, Biotechnology and Molecular Tools; Volume 2. Agronomic, Abiotic and Biotic Stress Traits and Volume 3. Fruits. In 2019, the following four volumes were published: Volume 4. Nut and Beverage Crops, Volume 5. Cereals, Volume 6. Industrial and Food Crops and Volume 7. Legumes. Recent volumes published in 2021 include: Volume 8. Vegetable Crops: Bulbs, Roots and Tubers, Volume 9. Vegetable Crops: Fruits and Young Shoots and Volume 10. Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles. This Volume 10, subtitled Vegetable Crops: Leaves, Flowerheads, Green Pods, Mushrooms and Truffles, consists of 14 chapters focusing on advances in breeding strategies using both traditional and modern approaches for the improvement of individual vegetable crops. Chapters are arranged in 4 parts according to the edible vegetable parts. Part I: Leaves - Chicory, Chinese cabbage, Rocket salad, Spring onion, Water spinach and Watercress; Pat II: Flowerheads and Green Pods - Cauliflower, Globe artichoke, Garden pea and Yardlong bean; Part III: Mushrooms - Enoki mushroom and Shiitake mushroom; Part IV: Truffles - Desert truffles and White truffle. Each chapter comprehensively reviews the contemporary literature on the subject and reflects the experiences of the authors. Chapters are written by internationally-reputable scientists and subjected to a review process to assure quality presentation and scientific accuracy. Each chapter begins with an introduction covering related backgrounds and provides in-depth discussion of the subject supported with high-quality color photos, illustrations and relevant data. The chapter concludes with recommendations for future research directions, a comprehensive list of pertinent references to facilitate further reading, and appendixes of genetic resources and concerned research institutes. This book series is a valuable resource for advanced students, researchers, scientists, commercial producers and seed companies as well as consultants and policymakers interested in agriculture, particularly in modern breeding technologies.
    Type of Medium: Online Resource
    Pages: XVII, 540 p. 98 illus., 76 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030669690
    DDC: 630
    Language: English
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  • 81
    Keywords: Plant anatomy. ; Stress (Physiology). ; Plants. ; Plant physiology. ; Plant ecology. ; Plants Development. ; Agriculture. ; Plant Anatomy and Morphology. ; Plant Stress Responses. ; Plant Physiology. ; Plant Ecology. ; Plant Development. ; Agriculture.
    Description / Table of Contents: Crosstalk between autophagy and hormones for abiotic stress tolerance in plants -- Abscisic acid and plant response under adverse environmental conditions -- Auxins and plant response to adverse environmental conditions -- Jasmonic acid for sustainable plant growth and production under adverse environmental conditions -- Salicylic acid for vigorous plant growth and enhanced yield under harsh environment -- Strigolactones for sustainable plant growth and production under adverse environmental conditions -- Polyamines for sustainable plant growth and production under adverse environmental conditions -- Plant performance and defensive role of proline under environmental stress -- Plant performance and defensive role of β-amino butyric acid under environmental stress -- Plant performance and defensive role of γ-gamma amino butyric acid under environmental stress -- Nitric oxide: A key modulator of plant responses under environmental stress -- Functions of hydrogen sulfide in plant regulation and response to abiotic stress -- Silicon and plant responses under adverse environmental conditions -- Nanofertilizers as tools for plant nutrition and plant biostimulation under adverse environment -- Biostimulants and plant response under adverse environmental conditions: a functional interplay -- Biofertilizers-mediated sustainable plant growth and production under adverse environmental conditions -- Seed priming: A cost-effective strategy to impart abiotic stress tolerance -- Significance of cyanobacteria in soil-plant system and for ecological resilience -- Phytomicrobiome community: An agrarian perspective -- Adverse environment and pest management for sustainable plant production -- Eco-friendly approaches of using weeds for sustainable plant growth and production.
    Abstract: Global climate change is bound to create a number of abiotic and biotic stresses in the environment, which would affect the overall growth and productivity of plants. Like other living beings, plants have the ability to protect themselves by evolving various mechanisms against stresses, despite being sessile in nature. They manage to withstand extremes of temperature, drought, flooding, salinity, heavy metals, atmospheric pollution, toxic chemicals and a variety of living organisms, especially viruses, bacteria, fungi, nematodes, insects and arachnids and weeds. Incidence of abiotic stresses may alter the plant-pest interactions by enhancing susceptibility of plants to pathogenic organisms. These interactions often change plant response to abiotic stresses. Plant growth regulators modulate plant responses to biotic and abiotic stresses, and regulate their growth and developmental cascades. A number of physiological and molecular processes that act together in a complex regulatory network, further manage these responses. Crosstalk between autophagy and hormones also occurs to develop tolerance in plants towards multiple abiotic stresses. Similarly, biostimulants, in combination with correct agronomic practices, have shown beneficial effects on plant metabolism due to the hormonal activity that stimulates different metabolic pathways. At the same time, they reduce the use of agrochemicals and impart tolerance to biotic and abiotic stress. Further, the use of bio- and nano-fertilizers seem to hold promise to improve the nutrient use efficiency and hence the plant yield under stressful environments. It has also been shown that the seed priming agents impart stress tolerance. Additionally, tolerance or resistance to stress may also be induced by using specific chemical compounds such as polyamines, proline, glycine betaine, hydrogen sulfide, silicon, β-aminobutyric acid, γ-aminobutyric acid and so on. This book discusses the advances in plant performance under stressful conditions. It should be very useful to graduate students, researchers, and scientists in the fields of botanical science, crop science, agriculture, horticulture, ecological and environmental science.
    Type of Medium: Online Resource
    Pages: XIV, 606 p. 54 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030785215
    DDC: 571.32
    Language: English
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  • 82
    Keywords: Biotechnology. ; Microtechnology. ; Microelectromechanical systems. ; Enzymology. ; Nanotechnology. ; Biotechnology. ; Microsystems and MEMS. ; Enzymology. ; Nanotechnology.
    Description / Table of Contents: Immobilization: Then and Now -- Cell immobilization strategies for tissue engineering: Recent trends and future perspectives -- Strategies and advancement in growth factor immobilizable ECM for tissue engineering -- Prospects Of Cell Immobilization In Cancer Research And Immunotherapy -- Nano systems for repairing retinal degeneration -- Systemic drug delivery to the posterior segment of the eye: Overcoming blood-retinal barrier through smart drug design and nanotechnology -- The effects of irradiation with cold atmospheric-pressure plasma on cellular function -- Immobilization of biomolecules on plasma functionalized surfaces for biomedical applications -- A wide portray of Upconversion-nanoparticles: surface modification for bio-applications -- Advances in Amphiphilic Assemblies and its Immobilization in Room Temperature Supercooled Matrices. .
    Abstract: This book delves into the field of immobilizing biologically active and non-active molecules. It discusses the designing strategy of immobilization and the current state-of-the-art applications for advancing biomedical, agricultural, environmental and industrial practices. It focuses on aspects ranging from fundamental principles to current technological advances at multi-scale levels (macro, micro, and nano) which are suitable for cell, enzyme, and nano-catalyst based applications. Written by experts from across the globe, the contents deal with illustrated examples of molecular and cellular interactions with materials/scaffolds and discussions on factors that can affect the functionality and yield of the process. With its discussions on material science, design of delivery vehicles, separation science, additive manufacturing, agriculture and environmental science, this book will be a useful reference for researchers across multiple disciplines.
    Type of Medium: Online Resource
    Pages: X, 666 p. 143 illus., 126 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811579981
    Series Statement: Gels Horizons: From Science to Smart Materials,
    DDC: 660.6
    Language: English
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  • 83
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030471897
    Series Statement: Advances in Experimental Medicine and Biology, 1270
    DDC: 571.978
    Language: English
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  • 84
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biochemistry. ; Genetics. ; Biomedical Research. ; Biochemistry. ; Genetics and Genomics.
    Description / Table of Contents: Central dogma of molecular biology -- Impact of chromatin structure -- Epigenetics enables gene expression -- Gene regulation in the context of nuclear architecture -- Core promoter -- TATA box and other core promoter elements -- Genome-wide core promoter identification -- TFIID and Mediator as paradigms of multi-protein complexes -- Site-specific transcription factors and their domains -- Classification of transcription factors -- Activation of transcription factors -- Programing cellular differentiation by transcription factors -- Inflammatory signaling via NF-KB -- Sensing cellular stress via p53 -- The nuclear receptor superfamily -- Molecular interactions of nuclear receptors -- Physiological role of nuclear receptors -- Next-generation sequencing -- Gene regulation in the context of Big Biology -- Exploring genome-wide transcription factor binding -- Integrating epigenome-wide datasets -- Cytosines and their methylation -- Histone modifications -- Gene regulation via chromatin modifiers -- Sensing energy metabolism via chromatin modifiers -- Epigenetics and chromatin -- Genome-wide understanding of epigenetics -- CTCF and genetic imprinting -- Epigenetics in health and disease -- Nucleosome positioning at promoters -- Chromatin remodeling -- Transcriptional dynamics in the presence of chromatin -- Organization of the nucleus -- Non-coding RNAs -- miRNAs and their regulatory potential -- Long ncRNAs -- Enhancer RNAs.
    Abstract: This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of gene expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. Th is pivotal role for the regulation of gene expression makes this textbook essential reading for students of all the biomedical sciences, in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation.
    Type of Medium: Online Resource
    Pages: XVI, 149 p. 71 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030523213
    DDC: 610.72
    Language: English
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  • 85
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Stem cells. ; Hematology. ; Regenerative medicine. ; Biotechnology. ; Stem Cell Biology. ; Hematology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Hematopoietic Stem Cells -- Mesenchymal Stem Cells -- Cord Blood Stem Cells -- Neural Stem Cells and Their Niche -- Skeletal Muscle Stem Cells -- Heart Muscle Tissue Engineering -- Induced Pluripotent Stem Cells -- Epigenetics of Somatic Cell Reprogramming -- Human Pluripotent Stem Cells and Neural Regeneration -- Dopaminergic Neuron-Related Stem Cells -- Liver Disease Modelling -- Organoids in Developmental Biology Research and Application -- Extracellular Vesicles -- Ethics in Stem Cell Applications.
    Abstract: This textbook describes the biology of different stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal cord blood, neural and muscle stem cells and also covers induced pluripotent stem cells and their applications. Further, it includes chapters on organoids, stem-cell based disease modelling, extracellular vesicles and one chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material. Based on lectures of the international master program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and participation of collaborating professors from Tongji University Shanghai, the book is a valuable source for students, postdocs and researchers, who would like to have introductory chapters on stem cell biology. It also offers essential insights for physicians and dentists wishing to expand their knowledge. This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.
    Type of Medium: Online Resource
    Pages: XIV, 242 p. 37 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030339234
    Series Statement: Learning Materials in Biosciences,
    DDC: 660.6
    Language: English
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  • 86
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Agriculture. ; Plant biotechnology. ; Plants Development. ; Agriculture. ; Plant Biotechnology. ; Plant Development.
    Description / Table of Contents: Chapter 1. Plant Breeding & Indian Agriculture -- Chapter 2. Plant Breeding & Seed Industry in India -- Chapter 3. Role of Education to Strengthen Plant breeding Capacity -- Chapter 4. Strategies to Strengthen Plant Breeding Status in India.
    Abstract: Plant breeding has the potential to improve quality of life for millions of people, and to harmoniously link agriculture, societies and ecosystems. Global efforts have been made to improve awareness and create a better and brighter future for plant breeding worldwide. Though substantial international research funding is available, and tremendous efforts have been made to achieve food security and sustainability in agriculture, their success can only be ensured when they are complemented by counterparts at the national level. India is ideally poised to reap the benefits of plant breeding by integrating various parameters like adaptation, uncertainty, vulnerability and resilience into agriculture research strategies. Priorities include making agriculture more appealing to young talents, formulating farmer-friendly policies, combining advanced technologies with conventional plant breeding practices, and building the competencies needed to address emerging challenges in agriculture. This book provides an essential overview of modern plant breeding, and demonstrates how education, entrepreneurship training and professional approaches can help transform the image of agriculture from a poor and unattractive domain into a lucrative and business-oriented one. In addition, it presents strategies to help achieve sustainable, accessible and affordable outcomes with breeding programs. The book’s primary goal is to encourage policymakers, academics, private institutions and non-profit organizations to combine their efforts in order to achieve a major transition in plant breeding activities in Asia. Accordingly, it highlights the importance of partnerships and collaborations for making breeding programs more comprehensive and meaningful.
    Type of Medium: Online Resource
    Pages: XIII, 127 p. 24 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811519062
    DDC: 630
    Language: English
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  • 87
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Neurosciences. ; Neurology . ; Evolution (Biology). ; Psychobiology. ; Human behavior. ; Neuroscience. ; Neurology. ; Evolutionary Biology. ; Behavioral Neuroscience.
    Description / Table of Contents: Sleep: Basic and Historical Aspects -- Sleep: Findings in Invertebrates and Lower Vertebrates -- Sleep: Evolutionary and Adaptive Changes in Birds and Mammals -- Sleep Loss: What Does it do to our Brain and Body -- Sleep: Neural Optimization as An Ultimate Function for Memory Consolidation -- Sleep: Disorders and Clinical Implications.
    Abstract: This book discusses the evolution of sleep and its possible function in the higher invertebrates and vertebrates, including humans. It describes the current concept of sleep and its functions, based on research on the mammalian system. To date, electrophysiological recordings of the brain waves, muscle activity, and eye movements are the only tools available for characterizing the sleep architecture in the majority of animals. In mammals and birds, only two distinct types of sleep are found – non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Since the discovery of REM sleep, studies have been performed to understand the purpose of the two distinct sleep states in higher vertebrates (birds and mammals), and how REM sleep was evolved. The book summarizes the role of both REM and NREM sleep in the proper functioning of the brain and body. It covers various aspects of the role of sleep in important physiological processes, including memory consolidation, induction of synaptic plasticity, energy restoration, enhancing immune response, and maturation of neuronal circuitries during early life. Lastly, the book reviews the effects of chronic/acute sleep deprivation on memory consolidation, obesity, and the immune system in animal models and humans.
    Type of Medium: Online Resource
    Pages: XIV, 118 p. 30 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811571756
    DDC: 612.8
    Language: English
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  • 88
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.
    Description / Table of Contents: 1 Principles of pharmaceutical analysis in drug stability and chemical kinetics -- 2 Guidelines for drug stability and stability testing -- 3 Chemical kinetics and its applications in drug stability -- 4 Methods and protocols for drug stability studies -- 5 Physical basis of degradation of pharmaceutical products -- 6 Role of microbiological degradation on drug stability -- 7 Role of decomposition on drug stability -- 8 Role of catalysis in drug stability -- 9 Analytical techniques for the assessment of drug stability -- 10 Stability of pharmaceutical products -- 11 Role of kinetic models in drug stability -- 12 Stability studies of vaccines -- 13 Stability studies of proteinous compounds -- 14 Stability studies of extemporaneous pharmaceutical products -- 15 Stability studies of parenteral products -- 16 Stability studies of solid dosage forms.
    Abstract: This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .
    Type of Medium: Online Resource
    Pages: XIV, 284 p. 22 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564260
    DDC: 615
    Language: English
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  • 89
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Medical sciences. ; Cytology. ; Biochemistry. ; Nutrition   . ; Immunology. ; Health Sciences. ; Cell Biology. ; Biochemistry. ; Nutrition.
    Description / Table of Contents: Preface -- Amino acids in intestinal physiology and health -- Amino acid metabolism in the liver: nutritional and physiological significance -- Amino acids in circulatory function and health -- Epithelial dysfunction in lung diseases: effects of amino acids and potential mechanisms -- Amino acid metabolism in the kidneys: nutritional and physiological significance -- Amino acids in health and endocrine function -- Amino Acids in Reproductive Nutrition and Health -- Impacts of amino acids on the intestinal defensive system -- Maternal nutrient restriction and skeletal muscle development: Consequences for postnatal health -- Metabolism of amino acids in the brain and their roles in regulating food intake -- Metabolism and functions of amino acids in the skin -- Metabolism and functions of amino acids in sense organs. .
    Abstract: This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in all the systems of humans and other animals (including livestock, poultry, companion animals, and fish). It enables readers to understand the crucial roles of amino acids and their metabolites in the health and diseases of the circulatory, digestive, endocrine, immune, muscular, nervous, reproductive, respiratory, skeletal, and urinary systems, as well as the sense organs (eyes, ears, nose, skin, and tongue). Readers will learn that amino acids are not only the building blocks of protein, but are also signalling molecules, as well as regulators of gene expression, metabolic processes and developmental changes in the body. This knowledge will guide nutritional practices to improve the growth, development and health of humans and other animals, as well as prevent and treat chronic (e.g., obesity, diabetes, and cardiovascular disorders) and infectious (e.g., bacterial, fungal, parasite, and viral) diseases. Editor of this volume is an internationally recognized expert in nutritional biochemistry. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals as well as undergraduate and graduate students in animal science, biochemistry, biomedical engineering, biology, human medicine, food science, kinesiology, nursing, nutrition, pharmacology, physiology, toxicology, veterinary medicine, and other related disciplines. In addition, all chapters provide general and specific references to amino acids in systems health for researchers and practitioners in biomedicine, animal and plant agriculture, and aquaculture, and for government policy makers.
    Type of Medium: Online Resource
    Pages: VI, 220 p. 36 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030453282
    Series Statement: Advances in Experimental Medicine and Biology, 1265
    DDC: 571.96
    Language: English
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  • 90
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Engineering design. ; Heart Surgery. ; Control engineering. ; Robotics. ; Automation. ; Biotechnology. ; Engineering Design. ; Cardiac Surgery. ; Control, Robotics, Automation.
    Description / Table of Contents: Chapter 1. Evolution of Artificial Heart Technology -- Chapter 2. Mechanisms of Heart Failure -- Chapter 3. Basis of Artificial Heart Technologies -- Chapter 4. Artificial Heart: Rotary Pump -- Chapter 5. Artificial Heart: Volume-Displacement Pump -- Chapter 6. Total Artificial Heart -- Chapter 7. Evaluation of Artificial Hearts -- Chapter 8. Selection of Artificial Heart Devices -- Chapter 9. Therapy Management of VADs -- Chapter 10. Challenges of Artificial Heart Devices -- Chapter 11. A Primary Study for Biocompatible Ventricular Assist Devices.
    Abstract: This book provides a comprehensive introduction to artificial hearts, summarizing the latest advances in basic technologies, design, evaluation, and management. Featuring 11 chapters, it discusses the origins of the artificial heart, the mechanisms of heart failure, and the principles of artificial heart technologies. Further, it offers an overview of rotary pumps and volume-displacement pumps, and addresses total artificial hearts. Lastly, the book covers evaluation, selection, therapy management, challenges, and the latest innovations. Given its scope, it is a valuable resource for researchers and technicians in the area of biomedical engineering, as well as surgeons.
    Type of Medium: Online Resource
    Pages: XV, 212 p. 37 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811543784
    DDC: 660.6
    Language: English
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  • 91
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Biochemistry. ; Physiology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Biochemistry. ; Physiology.
    Description / Table of Contents: Preface -- Part 1 Basics on coenzyme Q -- Introduction. The current coenzyme Q science and knowledge -- Molecular structure, biosynthesis, and distribution of coenzyme Q -- Coenzyme Q function in mitochondria -- Extramitochondrial coenzyme Q10 in aging -- Regulation of the synthesis of Coenzyme Q10 -- Part 2 Coenzyme Q in aging studies -- Coenzyme Q and aging in C. elegans -- Coenzyme Q and aging in the fruit fly Drosophila melanogaster -- The aging process and coenzyme Q: clk-1 mouse models -- Reduced coenzyme Q10 decelerates senescence and age-related hearing loss in senescence-accelerated mice by activating mitochondrial functions -- Part 3 Age-related diseases and coenzyme Q -- Coenzyme Q, mtDNA and mitochondrial dysfunction during aging -- Coenzyme Q10 and metabolic syndrome -- Coenzyme Q and age-related neurodegenerative disorders: Parkinson and Alzheimer diseases -- Immunosenescence and CoQ10 -- Coenzyme Q10 in fertility and reproduction -- Part 4 Prolongevity effectors and Coenzyme Q -- Calorie restriction, longevity and coenzyme Q -- Age dependent changes of coenzyme Q levels and its induction in experimental systems -- Effects of coenzyme Q10 supplementation on elderly people -- Index.
    Abstract: This book offers a comprehensive exploration of research on the essential relationship of the coenzyme Q10 and the process of aging in living organisms. CoQ10 is an important factor in two main aspects of cell physiology: bioenergetics and antioxidant protection. While primary deficiency of CoQ10 is associated with severe and lethal disease, secondary deficiency can be associated with the progression of mitochondrial dysfunction linked to the lessening of biological activities during aging. The book is organized in four sections. The first offers an overview of the function of CoQ10, highlighting the two main functions of CoQ10 in cells: its essential role as electron transport chain member in mitochondria, and the protection of cell membranes against oxidation as one of the main endogenous-synthesized antioxidants. The second section covers research on Coenzyme 10. Topics include studies involving invertebrate models, mammal studies and the influence of CoQ on longevity. Also covered is research involving the role of CoQ in senescence-accelerated mice. Section three examines the effects of reduced CoQ in human aging, as evident in mitochondrial dysfunction, metabolic syndrome, neurodegenerative disorders, immunosenescence and fertility and reproduction. The final section, Prolongevity effectors and Coenzyme Q, explores research into slowing or stopping the aging process. Coverage includes strategies including calorie restriction, and modulation of CoQ10 levels by induction of synthesis or by supplementation. Coenzyme Q in Aging benefits a broad readership of researchers, clinicians, educators and students interested in the biochemical and physiological effects of coenzyme Q and the importance of this molecule in aging process.
    Type of Medium: Online Resource
    Pages: XII, 369 p. 50 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030456429
    DDC: 610.72
    Language: English
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  • 92
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biochemistry. ; Food science. ; Biochemistry. ; Food Science.
    Description / Table of Contents: Chapter 1. History of Starch Research -- Chapter 2. Botanical Sources of Starch -- Chapter 3. Fine Structure of Amylose and Amylopectin -- Chapter 4. Multi-scale Structures of Starch Granules -- Chapter 5. Amylose-Lipid Complex -- Chapter 6. Phase Transitions of Starch and Molecular Mechanisms -- Chapter 7. Rheological, Pasting and Textural Properties of Starch -- Chapter 8. Starch Modification and Application -- Chapter 9. In vitro Starch Digestion: Mechanisms and Kinetic Models.
    Abstract: The book summarizes the latest research on starch structures and how these structures occur during food processing and storage. Discussing the origins, multi-scale granule structures and functional properties of starch as well as starch digestion, it focuses on the relationship between starch structure and functionality, the phase transition mechanism, the molecular disassembly and self-assembly of starch during food processing and storage and their effects on starch digestion. As such, the book provides a comprehensive overview of starch structure and functionality for researchers and postgraduate students in the field of food chemistry, carbohydrate polymers, polymer chemistry, food ingredients and food processing as well as human nutrition and health.
    Type of Medium: Online Resource
    Pages: V, 179 p. 45 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811506222
    DDC: 572
    Language: English
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  • 93
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Urology. ; Biophysics. ; Human Physiology. ; Urology. ; Bioanalysis and Bioimaging.
    Description / Table of Contents: Introduction of human sperm ultrastructural morphology -- Ultrastructural morphology of human sperm head -- Ultrastructural morphology of human sperm neck -- Ultrastructural morphology of human sperm middle piece -- Ultrastructural morphology of human sperm principal piece -- Ultrastructural morphology of human sperm terminal piece -- Ultrastructural morphological measurement of human sperm -- Artefacts of human sperm ultrastructural morphology -- Phenomena related to inadequate preparation of human sperm.
    Abstract: This atlas provides ultrastructural morphological images of human spermatozoa. Sperm morphology plays an essential role in sperm-oocyte interactions and early embryonic development, and human sperm ultrastructural morphology offers a valuable reference tool for assessing certain etiologies of male infertility and reproductive failure. However, the ultrastructural morphology of human sperm has not been systematically evaluated or thoroughly described in the literature. Using 470 original and unpublished images, the book shows various ultrastructural morphological phenotypes; defects of the sperm head, neck, middle piece, principal piece, and terminal piece; as well as artifacts of sperm ultrastructural morphology and phenomena related to inadequate preparation, demonstrating several sperm phenotypes and surface structural appearances for the first time. As such, it helps researchers and practitioners in andrology, reproductive medicine, and reproductive pathology gain a better understanding of human sperm ultrastructural morphology.
    Type of Medium: Online Resource
    Pages: XIII, 276 p. 370 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811553257
    DDC: 612
    Language: English
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  • 94
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Toxicology. ; Pharmacology. ; Toxicology. ; Pharmacology.
    Description / Table of Contents: 1. Exposure Durations of Environmental Stresses or Toxicants -- 2. Exposure Stages of Environmental Stresses or Toxicants -- 3. Complex Exposures to Environmental Toxicants or Stresses -- 4. Transgenerational Toxicity of Environmental Toxicants or Stresses -- 5. Exposure Routes of Environmental Toxicants -- 6. Basic Endpoints for Toxicity Assessment of Environmental Toxicants or Stresses -- 7. Endpoints for Assessing the Toxicity on Primary Targeted Organs -- 8. Endpoints for Assessing the Toxicity on Secondary Targeted Organs -- 9. Endpoints for Assessing the Toxicity on Biochemical Processes -- 10. Endpoints for Assessing the Genotoxicity and the Genetic Toxicity -- 11. Role of Exposure Dose in Toxicity Induction of Environmental Toxicants or Stresses -- 12. Role of Environmental Factors in Toxicity Induction of Environmental Toxicants or Stresses -- 13. Effects of Environmental Sample Forms on Toxicity Induction -- 14. Roles of Physicochemical Properties of Toxicants in Toxicity Induction -- 15. Roles of Environmental Media and Chemical Transformations of Environmental Toxicants in Toxicity Induction -- 16. Bioavailability, Enrichment, and Translocation of Environmental Toxicants -- 17. Susceptibility to Toxicants or Stresses Induced by Genetic Mutations -- 18. Contributors to Amplify the Toxicity of Toxicants or Stresses -- 19. Exposure to Certain Environmental Stresses -- 20. High-Throughput Toxicity Assessment -- 21. Toxicity Assessment under the Pathological Conditions.
    Abstract: This book focuses on exposure toxicology in C. elegans. The nematode Caenorhabditis elegans is sensitive to various environmental toxicants and stresses, and has proven to be an important animal model in both molecular and target-organ toxicology. As a result, over the past 30 years, there has been extensive research on the exposure to environmental toxicants or stresses in nematodes. Based on the available data, the book offers an introduction to the exposure system established in nematodes, discussing various aspects of endpoints that can potentially be used to assess the toxicity of environmental toxicants or stresses. Also exploring various factors affecting toxicity induction, and exposure to environmental toxicants and stresses, it allows readers to gain a systematic understanding of exposure toxicology in C. elegans. .
    Type of Medium: Online Resource
    Pages: XIX, 682 p. 447 illus., 303 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811561290
    DDC: 615.90072
    Language: English
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  • 95
    Keywords: Fungi. ; Mycology. ; Microbiology. ; Agriculture. ; Plants Evolution. ; Plant biotechnology. ; Plants Development. ; Fungi. ; Agriculture. ; Plant Evolution. ; Plant Biotechnology. ; Plant Development.
    Description / Table of Contents: Preface -- Introduction to Agriculturally Important Fungi for Crop Protection -- Role of Fungi in Adaptation of Agriculture Crops to Abiotic Stresses -- Arbuscualr Mycorrhizae Associations and Role in Mitigation of Drought Stress in Plants -- Fungal Mediated Alleviation of Cold Stress for Growth and Yield of Cereal Crops -- Soil Salinity and their Alleviation Using Plant Growth Promoting Fungi -- Phytohormones Producing Fungal Communities -- Fungal Secondary Metabolites and Bioactive Compounds for Plant Defence -- Fungal Endophytes -- Aspergillus Mycotoxins -- Trichoderma -- Piriformospora indica -- Bioresources for Control of Plant Parasitic Nematodes -- Global Scenario of Advance Fungal Research in Biocontrol and Crop Protection -- Index -- .
    Abstract: Microbes are ubiquitous in nature. Among microbes, fungal communities play an important role in agriculture, the environment, and medicine. Vast fungal diversity has been found in plant systems. The fungi associated with any plant system are in the form of epiphytic, endophytic, and rhizospheric fungi. These associated fungi play important roles in plant growth, crop yield, and soil health. The rhizospheric fungi present in rhizospheric zones have a sufficient amount of nutrients released by plant root systems in the form of root exudates for growth, development, and activities of microbes. Endophytic fungi enter in host plants mainly through wounds that naturally occur as a result of plant growth, or develop through root hairs and at epidermal conjunctions. The phyllospheric fungi may survive or proliferate on leaves, depending on the extent of influences of material in leaf diffuseness or exudates. The diverse group of fungal communities is a key component of soil-plant systems, where they are engaged in an intense network of interactions in the rhizospheric, endophytic, and phyllospheric areas, and they have emerged as an important and promising tool for sustainable agriculture. These fungal communities help to promote plant growth directly or indirectly by mechanisms for plant growth-promoting (PGP) attributes. These PGP fungi can be used as biofertilizers, bioinoculants, and biocontrol agents in place of chemical fertilizers and pesticides in an environmentally and eco-friendly manner. This book covers the current knowledge of plant-associated fungi and their potential biotechnological applications in agriculture and allied sectors. This book should be useful to scientists, researchers, and students of microbiology, biotechnology, agriculture, molecular biology, environmental biology, and related subjects.
    Type of Medium: Online Resource
    Pages: XVIII, 370 p. 40 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484743
    Series Statement: Fungal Biology,
    DDC: 579.5
    Language: English
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  • 96
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Surgery. ; Blood-vessels Surgery. ; Neurology . ; Neurosurgery. ; Vascular Surgery. ; Neurology.
    Description / Table of Contents: Brief History of Cavernous Malformations -- Definition and structure of cerebral cavernous malformations -- Molecular Biology of CCM -- Presentation -- Neuroimaging of Cerebral Cavernous Malformations -- Natural history of cavernous malformations -- Hemispherical Cavernomas in non-eloquent and eloquent areas -- Cavernoma-Related Epilepsy -- Surgery of deep-seated cavernous malformations -- Surgery of brainstem and cerebellar cavernous malformations -- Stereotactic Radiosurgery of Cavernous Malformations -- Cavernomas in children -- Cavernomas During Pregnancy -- Spinal cavernous malformations -- Intraorbital cavernous malformations.
    Abstract: This book presents a complete up-to date description of cavernoma disease together with its known biology, genetics and variable clinical presentation. It facilitates improved decision-making on surgical intervention by presenting different cases, highlighting the particular features of lesions such as anatomical location, eloquences of adjacent brain and type of presentation that are important when making decisions. In addition, the reader is brought up to speed with developments in the neuroimaging and active treatment techniques, especially surgical resection and radiosurgery. Finally, the natural history of the disease is taken into account and compared to the possible benefits of surgical treatment. Cavernomas of the CNS: Basic Science to Clinical Practice provides a comprehensive overview from the fundamentals of this condition, to special patient groups such as children and pregnant women. Therefore, it is an indispensable resource for neurovascular surgeons, neurosurgical residents and neurologists.
    Type of Medium: Online Resource
    Pages: VIII, 245 p. 124 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030494063
    DDC: 617.48
    Language: English
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  • 97
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Microbial ecology. ; Biotechnology. ; Environment. ; Industrial microbiology. ; Bacteria. ; Microbial Ecology. ; Biotechnology. ; Environmental Sciences. ; Industrial Microbiology. ; Bacteria.
    Description / Table of Contents: Part 1. Climate Change and Microbial Ecology -- Chapter 1. Microbes and Climate: A tangled relation -- Chapter 2. Carbon sequestration in aquatic system using Microbial pump -- Chapter 3. Climate change extenuation by green house gas quenching microflora -- Chapter 4. Role of Methanotrophs in Mitigating Global Warming -- Chapter 5. Paradigm Ecological Shift and Succession in Microbiomes – A Climatic Advent -- Chapter 6. Exploring the diversity of marine microbiome in response to changes in the environment -- Chapter 7. Polar microbes as climate resilient pathways for mitigation of climate change -- Part 2. Climate Change and pathogens -- Chapter 8. Climate change and population health -- Chapter 9. Impact of Climate Change on the Incidence and Transfer of Food and Water borne Diseases -- Chapter 10. Climate change: any dangers from antimicrobial resistant bacteria? -- Chapter 11. Phyllosphere Microbiome: Plant defense strategies -- Part 3. Climate Change and Agriculture -- Chapter Chapter 12. Understanding Methanogens, Methanotrophs and Methane Emission in Rice Ecosystem -- Chapter 13. Soil micro-flora and its role in diminution of global climate change -- Chapter 14. Role of microorganisms in plant adaptation towards climate change for sustainable agriculture -- Chapter 15. Novel approaches for genome editing to develop climate smart crops -- Part 4. Climate change and the Environmental Microbiology -- Chapter 16. Role of soil microbial flora in remediation of hydrocarbon stressed soils -- Chapter 17. Biosurfactant Producing Bacteria as Potent Scavengers of Petroleum Hydrocarbons -- Chapter 18. Potent biotechnological applications of psychrozymes -- Chapter 19. Role of Green Nanotechnology in Alleviating Climate Change.
    Abstract: This book covers the contemporary environmental issues faced by life on the planet and the role planetary microbiomes play in such issues. Providing insights on the net favorable and adverse effect of microbial processes, this volume covers both the spontaneous and anthropocentric events that impact climate change and life on the planet. The book describes the ecological significance of microbiomes associated with the kingdoms Plantae and Animalia with respect to climate change, natural and anthropogenic causes of climate change, microbial interactions in nature, planetary microbiomes and food security, climate change in relation to disease epidemiology and human health and engineering microorganisms to mitigate the consequences of climate change. The individual chapters in the intended book provide both theoretical and practical exposure to the current issues and future challenges of climate change in relation to the microbiomes. This collection should serve as ready reference to the researchers working in the area to reshape their future research in addressing the challenges of global climate change.
    Type of Medium: Online Resource
    Pages: XIII, 374 p. 41 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813345089
    DDC: 579.17
    Language: English
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  • 98
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.
    Abstract: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
    Type of Medium: Online Resource
    Pages: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756994
    DDC: 571.978
    Language: English
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  • 99
    Keywords: Human physiology. ; Immune system. ; Cellular signal transduction. ; Respiratory organs. ; Physiology. ; Diseases. ; Human Physiology. ; Immune Cell Signalling. ; Respiratory Physiology. ; Diseases.
    Description / Table of Contents: Chapter 1. Introduction to Lung Diseases -- Chapter 2. Targeting molecular and cellular mechanisms in asthma.-Chapter 3. Various cellular and molecular axis involved in the pathogenesis of asthma -- Chapter 4. Targeting molecular and cellular mechanisms in steroid resistant asthma -- Chapter 5. Targeting molecular and cellular mechanisms in chronic obstructive pulmonary disease -- Chapter 6. Probing the cellular and molecular mechanisms underlying in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) -- Chapter 7. Chronic obstructive pulmonary disease: Molecular basis of pathogenesis and targeted therapeutic approaches -- Chapter 8. Exploring the ‘dormancy-activation switch’ in the tumour microenvironment for metastatic lung cancer: The possible role of microRNA -- Chapter 9. Therapeutic strategies targeting signalling pathways in lung cancer -- Chapter 10. Modulation of signalling pathways by immunotherapeutics in lung cancer -- Chapter 11. Underpinning the Cellular and Molecular Mechanisms with Nanotheronstics for Lung Cancer -- Chapter 12. Targeting molecular and cellular mechanisms in Idiopathic Pulmonary Fibrosis.-Chapter 13. A refined approach to target the molecular and cellular mechanisms in pulmonary fibrosis.-Chapter 14. Targeting molecular and cellular mechanisms in tuberculosis -- Chapter 15. Cellular and Molecular Mechanisms of Repurposed antidiabetic drug as adjunctive treatment for tuberculosis -- Chapter 16. Targeting host and bacterial signaling pathways in tuberculosis: An effective strategy for the development of novel anti-tubercular therapies -- Chapter 17. Targeting molecular and cellular mechanisms in pulmonary hypertension -- Chapter 18. Targeting molecular and cellular mechanisms in pulmonary arterial hypertension -- Chapter 19. Potential cellular targets associated with the signaling and therapeutics of the pulmonary hypertension -- Chapter 20. Targeting molecular and cellular mechanisms in influenza A virus infections -- Chapter 21. Understanding the Biology of Non-typeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease through the Lens of Genomics -- Chapter 22. Targeting molecular and cellular mechanisms in rhinovirus infection -- Chapter 23. Targeting molecular and cellular mechanisms in respiratory syncytial virus (RSV) infection -- Chapter 24. Targeting molecular and cellular mechanisms SARS-CoV2 novel corona (COVID-19) virus infection -- Chapter 25. Underpinning the rudimentary mechanisms involved in the pathogenesis of SARS-CoV2 (COVID-19) in human lung cells -- Chapter 26. Targeting molecular and cellular mechanisms in SARS-CoV2 novel corona (COVID-19) virus infection -- Chapter 27. Special features of human lung ACE2 sensitivity to SARS CoV-2 spike glycoprotein -- Chapter 28. Implications of Phosphoinositide 3-kinase (PI3K) Signalling in cellular and molecular mechanisms of respiratory diseases -- Chapter 29. The role of the cholinergic system in lung diseases -- Chapter 30. The Nrf2-Keap1 signaling pathway in lung cancer -- Chapter 31. Role of Toll like receptor (LTR) in molecular and cellular mechanism of respiratory diseases -- Chapter 32. Biomarkers of Oxidative Stress -- Chapter 33. Targeting chronic lung diseases using advanced drug delivery systems -- Chapter 34. Plant based chemical moieties targeting cellular signalling pathways in chronic lung diseases -- Chapter 35. Role of phytoconstituents in targeting cytokines for managing pathophysiology of lung diseases -- Chapter 36. Targeting Cellular Signaling Pathways in Lung Cancer and Role of Phytochemicals as Novel Therapeutic Approach -- Chapter 37. Natural compounds targeting major signalling pathways in lung cancer -- Chapter 38. Drug delivery in respiratory diseases: Current opportunities, Molecular and cellular mechanism, and Future challenges -- Chapter 39. Future prospects and challenges in targeting cellular and molecular mechanisms in respiratory diseases.
    Abstract: The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.
    Type of Medium: Online Resource
    Pages: XIV, 926 p. 149 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813368279
    DDC: 612
    Language: English
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  • 100
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Invertebrates. ; Parasitology. ; Veterinary microbiology. ; Invertebrate Zoology. ; Parasitology. ; Veterinary Microbiology.
    Description / Table of Contents: 1.Origin and evolution of Triatominae -- 2. Taxonomy -- 3. Speciation Processes in Triatominae -- 4. Chromosome structure and evolution of Triatominae: A review -- 5. Embryonic development of the kissing bug Rhodnius prolixus -- 6. Anatomy of the nervous system of triatomines -- 7. Biogenic monoamines in the control of triatomine physiology with emphasis on Rhodnius prolixus -- 8. Structure and physiology of the neuropeptidergic system of triatomines -- 9. Sensory biology of triatomines -- 10. The behaviour of kissing-bugs -- 11. Features of interaction between triatomines and vertebrates based on bug feeding parameters -- 12. Blood Digestion in Triatomine Insects -- 13. The physiology of sperm transfer and egg production in vectors of Chagas disease with particular reference to Rhodnius prolixus -- 14. The Immune System of Triatomines -- 15. Interaction of triatomines with their bacterial microbiota and trypanosomes -- 16. The ecology and natural history of wild Triatominae in the Americas -- 17. Eco-epidemiology of vector-borne transmission of Trypanosoma cruzi in domestic habitats -- 18. Chagas Disease Vector Control -- 19. Insecticide resistance in triatomines -- 20. Perspectives in triatomine biology studies: “Omics”- based approaches.
    Abstract: This book aims to present updated knowledge on various aspects of the natural history, biology, and impact of triatomines to all interested readers. Each chapter will be written by authorities in the respective field, covering topics such as behavior, neurophysiology, immunology, ecology, and evolution. The contents will consider scientific, as well as innovative perspectives, on the problems related to the role of triatomine bugs as parasite vectors affecting millions in the Latin American region.
    Type of Medium: Online Resource
    Pages: XXX, 620 p. 62 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030645489
    Series Statement: Entomology in Focus, 5
    DDC: 592
    Language: English
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