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  • bic Book Industry Communication::M Medicine  (1,005)
  • Education  (792)
  • English  (1,468)
  • German  (328)
  • Russian
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  • 2020-2024  (1,795)
  • 1980-1984
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  • 1
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
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    Hochschulen in der Pandemie (2022)
    transcript Verlag | transcript Verlag
    Details
    Publication Date: 2024-03-29
    Description: Die Coronapandemie stellt Hochschulen vor bisher ungeahnte Herausforderungen. Digitalisierung und Online-Lehre bestimmen das Bild, während Campus und Seminarräume verwaisen. Welche Auswirkungen haben diese Veränderungen auf Studierende und Lehrende? Werden Diskriminierung und Exklusion durch digitale Lehre verstärkt oder gemindert? Und wie können Hochschulleitungen auf das »New Normal« reagieren? Die Zusammenführung von Forschungsergebnissen, Lessons Learned und Best Practice-Beispielen zeigt, wie sich Hochschulen - und Hochschullehre - durch die Erfahrungen aus der Pandemie verändern, und bietet Impulse für eine nachhaltige Hochschulentwicklung.
    Keywords: Hochschule ; Coronavirus ; Lehre ; Hochschulentwicklung ; Diversität ; Innovation ; Zukunft ; Verwaltung ; Resilienz ; Kommunikation ; Evaluation ; Bildung ; Internet ; Wissenschaft ; Universität ; Bildungsforschung ; Digitale Medien ; Pädagogik ; University ; Corona Virus ; Teaching ; Higher Education and University Development ; Diversity ; Future ; Administration ; Resilience ; Communication ; Education ; Science ; Educational Research ; Digital Media ; Pedagogy ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMN Universities ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNA Philosophy and theory of education
    Language: German
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  • 4
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    Messung von Experimentierfähigkeiten (2022)
    Logos Verlag Berlin | Logos Verlag Berlin
    Details
    Publication Date: 2023-02-02
    Description: Die vorliegende Arbeit beschäftigt sich mit der Validierung eines neuen Tests zur Messung von Experimentierfähigkeit in Large-Scale-Assessments. Die Testaufgaben erfordern die Planung, Durchführung und Auswertung typischer physikalischer Schülerexperimente der Sekundarstufe I. Anstelle von Realexperimenten werden interaktive Simulationen zum Aufbau von Experimenten und zur Durchführung von Messungen eingesetzt. Die Bearbeitung der Testaufgaben erfolgt vollständig am Computerbildschirm. Diesen Bearbeitungen werden in der Auswertung Punkte (Testwerte) zugewiesen. In der heute gültigen Vorstellung ist Validierung im Wesentlichen als ein theorie- und evidenzbasierter Argumentationsprozess aufzufassen. Nach der Nennung und Begründung notwendiger Validierungsschritte erfolgt eine schlüssige Validitätsargumentation. Ein Validierungsschritt kann z. B. darin bestehen, zu überprüfen, in wieweit zur erfolgreichen Bearbeitung der Testaufgaben Experimentierfähigkeiten eingesetzt werden. Die Ergebnisse der Validierungsschritte lassen sich wie folgt zusammenfassen: die Aufgabeninhalte und -anforderungen des Tests passen zum Physikunterricht der Sekundarstufe I; die Schüler denken und handeln bei der Bearbeitung der Testaufgaben experimentell; der verwendete Bewertungsmaßstab misst Experimentierfähigkeit; die erreichten Testwerte korrelieren mit den Testwerten, die bei inhaltlich identischen Realexperimenten erreicht werden. Zusammenfassend ist festzuhalten, dass der computerbasierte Test das Spektrum der in Large-Scale Assessments erfassbaren Experimentierfähigkeiten erweitert.
    Keywords: Education ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: German
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  • 5
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    Neuroimmune Interface in Health and Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 6
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    Inhibiting PARP as a Strategic Target in Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
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    Implementation of School-Based Management in Indonesia (2023)
    RAND Corporation
    Details
    Publication Date: 2024-03-29
    Description: This study provides a quantitative and qualitative status report on the implementation of school-based management (SBM) in Indonesia, identifies factors associated with the successful practices of SBM, and assesses SBM effects on student achievement eight years after inception. They found that the implementation so far has produced limited success and provide recommendations to strengthen the nation’s SBM practices.
    Keywords: Education ; History ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKC Curriculum planning & development ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKD Examinations & assessment ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs::JNSV Teaching of students with English as a second language (TESOL) ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history ; thema EDItEUR::J Society and Social Sciences::JN Education::JND Educational systems and structures::JNDG Curriculum planning and development ; thema EDItEUR::J Society and Social Sciences::JN Education::JND Educational systems and structures::JNDH Education: examinations and assessment ; thema EDItEUR::J Society and Social Sciences::JN Education::JNU Teaching of a specific subject ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history
    Language: English
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  • 8
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    International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 9
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    From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders；celiac disease；gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 10
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    Microglia in Health and Disease: A Unique Immune Cell Population (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 11
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 12
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    Schnittstelle Kunst - Vermittlung (2021)
    transcript Verlag
    Details
    Publication Date: 2024-03-29
    Description: Sieben Kunstschulen in Niedersachsen führten in den Jahren 2005 und 2006 Projekte entlang der Schnittstelle von Kunstproduktion und Bildungsarbeit durch. Dabei setzten sie sich mit Strategien der Gegenwartskunst auseinander, die auf Prozess, Kooperation und Intervention basieren. Das Buch bietet eine Reflexion und Theoretisierung dieser Projekterfahrungen und zeigt sowohl die Probleme als auch die Potenziale der Arbeit im Zwischenraum von Kunst und Bildung auf. Es möchte neue Impulse für die Kunstvermittlung geben, zu eigenen Experimenten und zum Weiterdenken anregen. Der partizipativ angelegte Forschungsprozess belegt, dass es möglich ist, die Komplexität der Prozesse in solchen Projekten zu analysieren und zu beschreiben und dabei die Beteiligung der Akteure und Akteurinnen als konstitutiv für den Erkenntnisprozess zu verstehen.
    Keywords: Kunst ; Bildung ; Vermittlung ; Kunstdidaktik ; Kulturmanagement ; Kunstmanagement ; Kulturelle Bildung ; Museumspädagogik ; Arts ; Education ; Cultural Management ; Art Management ; Cultural Education ; Museum Education ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
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  • 13
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    Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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  • 14
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    Medienkritikfähigkeit messbar machen (2021)
    W. Bertelsmann Verlag | W. Bertelsmann Verlag
    Details
    Publication Date: 2021-12-24
    Description: If parents are critical and reflective about the media, they can pass this ability on to their children. But what is this ability? How can it be recorded? In her dissertation, the author developed a test procedure and collected basic data to analyze the media criticism of parents of young children. Before that, she defined the term "media criticism", placed it in the theoretical context and used it to examine her results. The study shows that the social situation influences both media education and critical media dealings. Habitualized patterns of media use are also passed on within the family. This study opens a new field of research in media education, in which the role model function of parents in dealing with media is in focus. The relevance of the topic is obvious: parents shape the media criticism of their children, i.e. the adults of tomorrow. The author uses current examples to classify the social effects of a lack of reflection and criticism in dealing with the media.
    Keywords: Education ; Teaching Methods & Materials ; Science & Technology ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs::JNSV Teaching of students with English as a second language (TESOL)
    Language: German
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    COVID-19: Current Status and Future Prospects (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 16
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    Pathogenesis and Targeted Therapy of Epilepsy (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 17
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    Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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    Prognostic Factors for Pediatric Tumors (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Polymer Materials in Biomedical Application (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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    Legitime Sprachen, legitime Identitäten (2021)
    transcript Verlag | transcript Verlag
    Details
    Publication Date: 2024-03-24
    Description: Das Einüben der Fähigkeit, mit sprachlicher und kultureller Vielfalt produktiv umzugehen, ist ein Kernanliegen des zeitgemäßen Fremdsprachenunterrichts. Doch wie ist der Umgang mit dieser im Klassenzimmer organisiert? Daniel H. Rellstab analysiert auf der Basis eines von Erving Goffman geprägten Interaktionsverständnisses Interaktionen in »Deutsch als Fremdsprache«-Klassenzimmern. Dabei zeigt er, welche Ressourcen Lehrkräfte sowie Schülerinnen und Schüler in der Interaktion einsetzen, wie sie aushandeln, welche Sprachen legitim, welche illegitim sind, und wie sie dabei Identitäten und Normen re- und dekonstruieren.
    Keywords: Deutsch Als Fremdsprache ; Interaktion ; Interaktionsanalyse ; Multimodalität ; Mehrsprachigkeit ; Legitimität ; Sprachkompetenz ; Spracherwerb ; Didaktik ; Lernen ; Identität ; Normensystem ; Sprache ; Bildung ; Gesellschaft ; Sprachwissenschaft ; Interkulturalität ; Germanistik ; Bildungsforschung ; Pädagogik ; German As a Foreign Language ; Interaction ; Interaction Analysis ; Multimodality ; Multilinguism ; Legitimacy ; Language Competence ; Language Acquisition ; Didactics ; Learning ; Identity ; Standard System ; Language ; Education ; Society ; Linguistics ; Interculturalism ; German Literature ; Educational Research ; Pedagogy ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general
    Language: German
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    Benachteiligte Jugendliche in Ausbildung und Beruf individuell begleiten (2021)
    wbv Media | wbv Media
    Details
    Publication Date: 2023-02-01
    Description: Die "Assistierte Ausbildung" (AsA) soll als ein Arbeitsmarktinstrument benachteiligten Jugendlichen den Weg in Berufsausbildung und Beruf erleichtern, ihre Chancen auf den Abschluss einer Berufsausbildung erhöhen und Ausbildungsabbrüche vermeiden. Der Band dokumentiert die Ergebnisse der explorativ angelegten Begleitforschung. Grundlage der Studie sind qualitative Interviews zu Erwartungen, Verlauf und Ergebnissen der AsA mit Auszubildenden, Ausbildungsbetrieben sowie Fachkräften der Arbeitsagenturen und Bildungsdienstleister. Die Ergebnisse zeigen, dass die Assistierte Ausbildung einen wertvollen Beitrag zur Integration benachteiligter Jugendlicher in den Arbeitsmarkt leistet. Die Studie identifiziert jedoch auch Optimierungsbedarf, wie z. B. eine stärkere Flexibilisierung und Modularisierung, um noch besser auf die Bedürfnisse aller Akteure eingehen zu können.
    Keywords: Education ; Vocational ; bic Book Industry Communication::J Society & social sciences::JN Education::JNR Careers guidance::JNRV Industrial or vocational training
    Language: German
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    Preschool Adequacy and Efficiency in California (2023)
    RAND Corporation
    Details
    Publication Date: 2023-10-05
    Description: The California Preschool Study examined gaps in school readiness and achievement in the early grades among California children and the potential for high-quality preschool to close those gaps, the use of early care and education (ECE) services and their quality, and the system of publicly funded ECE programs for three- and four-year-olds. This analysis integrates the results from the prior studies and makes recommendations for preschool policy.
    Keywords: Sociology ; Management & Organizational Behavior ; Education ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJW Office & workplace::KJWX Working patterns & practices ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSP Age groups::JFSP1 Age groups: children
    Language: English
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    Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Recent advances in γδ T cell biology: New ligands, new functions, and new translational perspectives (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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    ME/CFS – the Severely and Very Severely Affected (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-01
    Description: Manuscripts in this monograph are sorted into five categories: 1. Case Reports: a description of living as a bedridden patient; structured interviews with severely affected ME/CFS patients; how past events contribute to severe ME/CFS; a comparison of moderately ill, severely ill, and very severely ill; case reports of ME/CFS in children. 2. A healthcare provider’s view of managing ME/CFS patients. 3. Characterization of the Severely and Very Severely Affected: (1) the most troubling symptoms; (2) disease severity diminishes capacity for exercise, (3) operationalized definitions of the severely ill and very severely ill; (4) the usefulness of a modified Korean Chalder Fatigue Scale Questionnaire; (5) cardiac dimensions and function in patients; (6) an easier tilt test; and (7) review of sleep studies. 4. Progress in Diagnosis and Treatment: (1) objective measures for grading ME/CFS; (2) a sitting tilt test for orthostatic intolerance; (3) the benefits of IVIgG; (4) risks and protective factors in suicidality; (5) malnutrition and overcoming it; (7) partnerships between patients, caregivers, and providers, and the use of technology; (8) a holistic model of care, “Compassion in Practice; and (9) the effects of suffering, utilizing a four-phase model. 5. Impact of the Disease: (1) a historical perspective; (2) the impact of ME/CFS on psychosocial dynamics; (3) the educational needs of school-aged; and (4) the economic impact of ME/CFS
    Keywords: Adolescence ; Adulthood ; Apnea ; Apnea-hypopnea index ; Bedbound ; Cardiac Function ; Cardiopulmonary Exercise Testing ; Caregivers ; Case Study ; Cerebral Blood Flow ; Chronic Fatigue Syndrome ; Clinical Presentation ; Compassion In Practice ; Diagnosis ; Economic Impact ; Education ; Enteral Nutrition ; EUROMENE ; Europe-Wide ; Grief ; Homebound ; Illness progression ; Immunoglobulin Therapy ; Infection ; Isolation ; IVIgG ; Jarisch&ndash ; Herxheimer Reaction ; Laboratory Tests ; Lived experience ; Loss ; Malnutrition ; Mental Health ; ME/CFS ; Moderately Ill ; Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ; Orthostatic Stress ; Parenteral nutrition ; Patient Assessment ; Patient Management ; Prevention ; Psychological Causation ; Psychosocial ; Severely Ill ; Sleep ; Social Isolation ; Stigma ; Student Learning ; Suicidality ; Symptoms ; Telemedicine ; Trauma ; Treatment ; Tube feeding ; Very Severely III ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
    Language: English
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    Traditional Medicines and Globalisation (2021)
    Maven Publishers
    Details
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
    Language: English
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    Research Topics in Medicines and How Our Board Members Are Engaged in Them (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
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    Investing in Our Children (2023)
    RAND Corporation
    Details
    Publication Date: 2023-10-05
    Description: There is increasing evidence that the first few years after birth are particularly important in child development and present opportunities for enrichment but also vulnerabilities do to poverty and other social stressors. Elected officials have begun proposing potentially costly programs to intervene early in the lives of disadvantaged children. Have such interventions been demonstrated to yield substantial benefits? To what extent might they pay for themselves through lower welfare and criminal justice costs incurred by participating children as they grow into adults? This study synthesizes the results of a number of previous evaluations in an effort to answer those questions. Conclusions are that under carefully controlled conditions, early childhood interventions can yield substantial advantages to recipients in terms of emotional and cognitive development, education, economic well-being, and health. (The latter two benefits apply to the children's families as well.) If these interventions can be duplicated on a large scale, the costs of the programs could be exceeded by subsequent savings to the government. However, the more carefully the interventions are targeted to children most likely to benefit, the more likely it is that savings will exceed costs. Unfortunately, these conclusions rest on only a few methodologically sound studies. The authors argue for broader demonstrations accompanied by rigorous evaluations to resolve several important unknowns. These include the most efficient ways to design and target programs, the extent to which effectiveness is lost on scale-up, and the implications of welfare reform and other safety net changes.
    Keywords: Education ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: English
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    Lines of Inquiry in Mathematical Modelling Research in Education (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2021-02-10
    Description: This open access book is based on selected presentations from Topic Study Group 21: Mathematical Applications and Modelling in the Teaching and Learning of Mathematics at the 13th International Congress on Mathematical Education (ICME 13), held in Hamburg, Germany on July 24–31, 2016. It contributes to the theory, research and teaching practice concerning this key topic by taking into account the importance of relations between mathematics and the real world. Further, the book addresses the “balancing act” between developing students’ modelling skills on the one hand, and using modelling to help them learn mathematics on the other, which arises from the integration of modelling into classrooms. The contributions, prepared by authors from 9 countries, reflect the spectrum of international debates on the topic, and the examples presented span schooling from years 1 to 12, teacher education, and teaching modelling at the tertiary level. In addition the book highlights professional learning and development for in-service teachers, particularly in systems where the introduction of modelling into curricula means reassessing how mathematics is taught. Given its scope, the book will appeal to researchers and teacher educators in mathematics education, as well as pre-service teachers and school and university educators
    Keywords: Mathematics Education ; Learning & Instruction ; Teaching and Teacher Education ; Education ; Pedagogical issues of integration into classroom practice ; assessment of modelling competencies ; teachers as learners of mathematical modelling ; technological influences on modelling education ; managing group interactions in modelling ; mathematical model ; modelling problems ; heuristic strategies ; teaching mathematical modelling ; modelling competencies ; learning mathematics modelling ; interpretations modelling ; pedagogical practice and research ; modelling perspective ; teaching practices in mathematical modelling ; Open Access ; Teaching of a specific subject ; Mathematics ; Teaching skills & techniques ; Cognition & cognitive psychology ; Teacher training ; bic Book Industry Communication::J Society & social sciences::JN Education::JNU Teaching of a specific subject ; bic Book Industry Communication::J Society & social sciences::JN Education::JNT Teaching skills & techniques ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMT Teacher training
    Language: English
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    Arbeitsplatzorientierte Grundbildung in der Pflegehilfe (2021)
    wbv Media | wbv Media
    Details
    Publication Date: 2023-02-02
    Description: Wie kann die Vermittlung von Grundbildung dazu beitragen, den Fachkräftemangel in der Pflege zu reduzieren? Die Autorinnen und Autoren des Sammelbandes stellen in ihren Beiträgen interdisziplinäre Forschungs- und Arbeitsergebnisse aus bundesweiten Projekten vor. Die Beiträge gliedern sich in drei Abschnitte: zum aktuellen Stand der Pflegehilfe, zur arbeitsplatzorientierten Grundbildung in der Pflegehilfe und zur Teilhabe an der Gesellschaft und dem Arbeitsmarkt. Es wird über Konzepte, Praxisbeispiele und Bildungsformate von Grundbildungsformaten in der Pflegehilfe berichtet.
    Keywords: Education ; Vocational ; bic Book Industry Communication::J Society & social sciences::JN Education::JNR Careers guidance::JNRV Industrial or vocational training
    Language: German
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    Chapter 2 Practical gender in critical pedagogy (2021)
    Taylor & Francis | Intersectional Pedagogy | Routledge
    Details
    Publication Date: 2024-03-29
    Description: This chapter offers a theoretical and methodological framework for implementing feminist critical pedagogy in compulsory courses in gender studies. The method examined presents a gender analysis of daily objects by students as a means of dealing with resistance to gender studies and feminist theory, as well as creating a consciousness-changing experience for the participants.
    Keywords: Creative ; Education ; Gal ; Gender ; Harmat ; Intersectional ; Peace ; Pedagogy ; Practices ; Work ; bic Book Industry Communication::J Society & social sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: English
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    Global health issues of aflatoxins in food and agriculture: Challenges and opportunities (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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    Emerging Materials for Additive Manufacturing (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Marine Compounds and Cancer (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
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    Personalized Medicine for Parkinson's Disease (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    Urological Cancer 2022 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Digital Transformation of Learning Organizations (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2021-02-10
    Description: This open access volume provides insight into how organizations change through the adoption of digital technologies. Opportunities and challenges for individuals as well as the organization are addressed. It features four major themes: 1. Current research exploring the theoretical underpinnings of digital transformation of organizations. 2. Insights into available digital technologies as well as organizational requirements for technology adoption. 3. Issues and challenges for designing and implementing digital transformation in learning organizations. 4. Case studies, empirical research findings, and examples from organizations which successfully adopted digital workplace learning.
    Keywords: Administration, Organization and Leadership ; Computers and Education ; Educational Technology ; Organization and Leadership ; Education ; Open Access ; Digital technologies for education ; Digital transformation ; Digital organizational learning and education ; Digital tools for change management ; Transformational learnins ; Transformation of educational organizations ; Educational administration & organization ; Educational equipment & technology, computer-aided learning (CAL) ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNV Educational equipment & technology, computer-aided learning (CAL)
    Language: English
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    Diagnostische Prozesse von Studierenden des Lehramts (2021)
    Logos Verlag Berlin | Logos Verlag Berlin
    Details
    Publication Date: 2024-04-04
    Description: Eine lernendenorientierte und adaptive Gestaltung von Unterricht erfordert von den Lehrkräften, dass sie vorhandene Kompetenzen und Lernprozesse der Schülerinnen und Schüler diagnostizieren. Außerdem müssen sie die Anforderungen von Aufgaben mit Blick auf deren Passung zu den Lernprozessen der Schülerinnen und Schüler analysieren können. Eine derart verstandene "diagnostische Kompetenz" wird als zentrales Professionalisierungsziel von Lehrkräften angesehen. Vor diesem Hintergrund wurden die diagnostischen Prozesse von acht Studierenden mit den Fächern Physik und Mathematik in zwei aufeinander folgenden Lehrveranstaltungen zur Diagnostik untersucht, um Potentiale und Lernhindernisse im Kompetenzaufbau zu identifizieren. In beiden Veranstaltungen bildeten Vignetten von Lernprozessen den Ausgangspunkt für studentische Diagnosen. Forschungsgegenstand waren u.a. schriftliche Diagnosen der Studierenden im Prä-Post-Vergleich sowie auf Video aufgezeichnete studentische Diskurse bei der Diagnose von Lernprozessen der Schülerinnen und Schüler. Die Analysen erfassen u.a., auf welche Komponenten eines Diagnoseprozesses die Studierenden in welcher Weise Bezug nehmen und welche (fach-) didaktischen überlegungen bzw. Theoriebezüge sie in ihren Diagnosen als Referenzpunkte nutzen. Die Ergebnisse zeigen, dass auf struktureller Ebene zwar alle Komponenten thematisiert, aber inhaltlich nicht entlang einer typischen Abfolge miteinander verbunden werden. Trotz inhaltlicher Prompts wird nur selten explizit auf Theoriebezüge zurückgegriffen.
    Keywords: Mathematics ; Education ; Science ; Physics ; thema EDItEUR::P Mathematics and Science::PB Mathematics ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::P Mathematics and Science::PH Physics
    Language: German
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    Epigenetics of B Cells and Antibody Responses (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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    Alte Geschichte und Archäologie im Gespräch. (2022)
    Georg Olms Verlag | Georg Olms Verlag
    Details
    Publication Date: 2024-04-06
    Description: 47 neugefundene Briefe von Theodor Mommsen waren der Anstoß, sie mit den Gegenbriefen des Archäologen Wolfgang Helbig aus der Staatsbibliothek zu Berlin in dieser Gesamtausgabe zu vereinigen. 28 Briefe Mommsens aus der Gelehrtenkorrespondenz des Archäologischen Instituts Rom, wo Helbig über 20 Jahre Zweiter Sekretär war, kamen hinzu. Dieses bisher unveröffentlichte Material von insgesamt 176 Briefen gewährt einen fesselnden Einblick in das wissenschaftliche Leben einer Zeit, in der Deutschland auf dem Gebiet der Altertumswissenschaft in der Welt führend war. Dabei entstehen die Charakterbilder zweier Vertreter ihrer Fächer, der Archäologie und der Alten Geschichte, was sie verband und was sie trennte. Die nahezu 1000 Anmerkungen vermitteln ein umfassendes Bild der damaligen Wissenschaftsgemeinschaft, in der die beiden mächtigen, aber höchst eigenwilligen Persönlichkeiten mit Entschiedenheit und Diplomatie über Jahrzehnte agierten. Nicht zuletzt wird man Zeuge dessen, wie mit dem aufkommenden Nationalismus auf beiden Seiten die ehemalige Internationalität der Forschung in die Brüche ging.
    Keywords: Education ; Teaching Methods & Materials ; thema EDItEUR::J Society and Social Sciences::JN Education::JNT Teaching skills and techniques
    Language: German
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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    Zweijährige Berufsausbildung im Kfz-Service (2022)
    wbv Media GmbH & Co. KG
    Details
    Publication Date: 2024-03-29
    Description: Seit 2004 gibt es in Deutschland den zweijährigen Ausbildungsberuf "Kfz-Servicemechaniker". Seine Einführung war umstritten, wurde aber auch als Chance für Bewerber mit schwachem Schulabschluss gesehen. Aus diesem Grund wurde die Erprobung von 2005 bis 2007 wissenschaftlich begleitet. Der Beruf gehört dadurch zu einem der am besten untersuchten Ausbildungsberufen. Befragt wurden Ausbilder, Auszubildende und Lehrende. Die Autoren stellen ergänzend Entwicklungen im Kfz-Service-Sektor und zum Ablauf der Ausbildung dar. Die allgemeine Diskussion von Vor- und Nachteilen der zweijährigen Ausbildung macht es möglich, die Ergebnisse auch auf andere Bereiche zu übertragen.
    Keywords: Education ; Vocational ; bic Book Industry Communication::J Society & social sciences::JN Education::JNR Careers guidance::JNRV Industrial or vocational training ; thema EDItEUR::J Society and Social Sciences::JN Education::JNR Careers guidance::JNRV Industrial or vocational training
    Language: German
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    The Governing-Evaluation-Knowledge Nexus (2021)
    Springer Nature
    Details
    Publication Date: 2021-02-10
    Description: This Open Access book analyses the interplay between governing, evaluation and knowledge with an empirical focus on Swedish higher education. It investigates the origins, logics, and mechanisms of evaluation and quality assurance reforms and their dynamic interactions with institutional, national and European policy contexts. The chapters report findings from extensive empirical studies that offer detailed insight into the work of governing in higher education, by giving voice to actors at various levels and positions including the ministry, national agency and University employees. Central themes include the influence of European policy, changing system designs, media relations and quality assurance enactments in University institutions. The book also explores the ways in which an emerging professional cadre, labelled qualocrats, enacts and mediates evaluation and quality assurance policy and practice. Taken together, the expanding evaluation machinery in Swedish higher education highlights the pivotal role of knowledge as a governing resource, and points to special features of evaluation as a particular form of practice that makes knowledge work for governing.
    Keywords: Education ; Higher education ; Assessment ; Educational policy ; Education and state ; Educational sociology ; School management and organization ; School administration ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKD Examinations & assessment ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education
    Language: English
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    Schulmusik für alle? (2023)
    transcript Verlag | transcript Verlag
    Details
    Publication Date: 2023-11-17
    Description: Warum obligatorischer Musikunterricht? Musikunterricht wird oft als ›nice-to-have‹ betrachtet und im Rahmen knapper Ressourcen in Frage gestellt. Der Begründungsdruck führt dazu, dass der Musik Wirkungen zugesprochen werden, die wissenschaftlich nicht haltbar sind. Ist das Schulfach Musik tatsächlich zu begründen? Wie soll es ausgerichtet sein? Gelingender Unterricht ist nicht nur von Lehrplan und Qualifikation der Lehrpersonen abhängig. Vielmehr spielen Haltungen und Überzeugungen von Lehrenden und Lernenden eine entscheidende Rolle. Markus Cslovjecsek zeigt auf, wo die Beteiligten die Legitimation von Musikunterricht sehen und richtet sich damit an alle, die an schulischem (Musik-)Unterricht und seiner Begründung interessiert sind - ein ›must-have‹ für alle Bildungsverantwortlichen.
    Keywords: Musik ; Musikunterricht ; Schule ; Musikpädagogik ; Lehrer ; Unterricht ; Bildung ; Lehrplan ; Lehrperson ; Schulmusik ; Curriculum ; Unterrichtsbegründung ; Bildungsforschung ; Kulturelle Bildung ; Musikwissenschaft ; Musikschule ; Music ; Music Lessons ; School ; Music Education ; Classroom Practices ; Education ; Teacher ; School Music ; Educational Research ; Cultural Education ; Musicology ; Music School ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education ; bic Book Industry Communication::A The arts::AV Music::AVA Theory of music & musicology
    Language: German
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    Continued Progress: Promising Evidence on Personalized Learning (2023)
    RAND Corporation
    Details
    Publication Date: 2024-03-29
    Description: This report examines achievement in 62 schools pursuing a variety of personalized learning practices, and implementation details in 32 of the schools. It uses data from site visits, interviews, and surveys to create a broad picture of efforts to implement personalized learning and the perceptions of teachers and students. Achievement data for personalized learning students are compared to a matched group of students attending other schools.
    Keywords: Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKD Examinations & assessment ; bic Book Industry Communication::J Society & social sciences::JN Education::JNT Teaching skills & techniques ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs::JNSV Teaching of students with English as a second language (TESOL) ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; thema EDItEUR::J Society and Social Sciences::JN Education::JND Educational systems and structures::JNDH Education: examinations and assessment ; thema EDItEUR::J Society and Social Sciences::JN Education::JNT Teaching skills and techniques ; thema EDItEUR::J Society and Social Sciences::JN Education::JNU Teaching of a specific subject ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy
    Language: English
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    e-Science (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-03-29
    Description: This open access book shows the breadth and various facets of e-Science, while also illustrating their shared core. Changes in scientific work are driven by the shift to grid-based worlds, the use of information and communication systems, and the existential infrastructure, which includes global collaboration. In this context, the book addresses emerging issues such as open access, collaboration and virtual communities and highlights the diverse range of developments associated with e-Science. As such, it will be of interest to researchers and scholars in the fields of information technology and knowledge management.
    Keywords: Science and Technology Studies ; Media and Communication ; Business Information Systems ; Computer Applications ; Education, general ; Knowledge Management ; Science Communication ; Computer and Information Systems Applications ; Digital Education and Educational Technology ; Open Access ; Grid computing ; Science 2.0 ; Research network ; Education portal ; Virtual organization ; Governance ; Social control ; Science collaboration ; Digitization ; Digital research infrastructures ; Cyberinfrastructure software ; Sustainability ; Software sustainability ; Sociology ; Media studies ; Business mathematics & systems ; Information technology: general issues ; Education ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJQ Business mathematics and systems ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMK Knowledge management
    Language: English
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    Immune responses to AAV vectors, from bench to bedside (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
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    Early Start (2021)
    University of Michigan Press | University of Michigan Press
    Details
    Publication Date: 2023-11-17
    Description: In the United States, preschool education is characterized by the dominance of a variegated private sector and patchy, uncoordinated oversight of the public sector. Tracing the history of the American debate over preschool education, Andrew Karch argues that the current state of decentralization and fragmentation is the consequence of a chain of reactions and counterreactions to policy decisions dating from the late 1960s and early 1970s, when preschool advocates did not achieve their vision for a comprehensive national program but did manage to foster initiatives at both the state and national levels. Over time, beneficiaries of these initiatives and officials with jurisdiction over preschool education have become ardent defenders of the status quo. Today, advocates of greater government involvement must take on a diverse and entrenched set of constituencies resistant to policy change.
    Keywords: Education ; Educational Policy & Reform ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy
    Language: English
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    Refiguring Prose Style (2023)
    University Press of Colorado | Utah State University Press
    Details
    Publication Date: 2024-03-29
    Description: For about two decades, say Johnson and Pace, the discussion of how to address prose style in teaching college writing has been stuck, with style standing in as a proxy for other stakes in the theory wars. The traditional argument is evidently still quite persuasive to some-that teaching style is mostly a matter of teaching generic conventions through repetition and practice. Such a position usually presumes the traditional view of composition as essentially a service course, one without content of its own. On the other side, the shortcomings of this argument have been much discussed-that it neglects invention, revision, context, meaning, even truth; that it is not congruent with research; that it ignores 100 years of scholarship establishing composition's intellectual territory beyond "service." The discussion is stuck there, and all sides have been giving it a rest in recent scholarship. Yet style remains of vital practical interest to the field, because everyone has to teach it one way or another. A consequence of the impasse is that a theory of style itself has not been well articulated. Johnson and Pace suggest that moving the field toward a better consensus will require establishing style as a clearer subject of inquiry. Accordingly, this collection takes up a comprehensive study of the subject. Part I explores the recent history of composition studies, the ways it has figured and all but effaced the whole question of prose style. Part II takes to heart Elbow's suggestion that composition and literature, particularly as conceptualized in the context of creative writing courses, have something to learn from each other. Part III sketches practical classroom procedures for heightening students' abilities to engage style, and part IV explores new theoretical frameworks for defining this vital and much neglected territory. The hope of the essays here-focusing as they do on historical, aesthetic, practical, and theoretical issues-is to awaken composition studies to the possibilities of style, and, in turn, to rejuvenate a great many classrooms.
    Keywords: Education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs::JNSV Teaching of students with English as a second language (TESOL) ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNU Teaching of a specific subject
    Language: English
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    Chapter 4 Preschool education (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-03-24
    Description: "The Routledge Handbook of Translation and Education will present the state of the art of the place and role of translation in educational contexts worldwide. It lays a sound foundation for the future interdisciplinary cooperation between Translation Studies and Educational Linguistics. By adopting a transdisciplinary perspective, the handbook will bring together the various fields of scholarly enquiry and practice that make a valuable contribution to enlarging the notion of translation and diversifying its uses in education. Each contribution provides an overview of the historical background to a given educational setting. Focusing on current research approaches and empirical findings, this volume outlines the development of pedagogical approaches, methods, assessment and curriculum design. The handbook also examines examples of pedagogies that integrate translation in the curriculum, the teaching method’s approach, design and procedure as well as assessment. Based on a multilingual and applied-oriented approach, the handbook is essential reading for postgraduate students, researchers and advanced undergraduate students of Translation Studies, and educationalists and educators in the 21st century post-global era."
    Keywords: Sara Laviosa ; Maria González-Davies ; Translation Studies ; Translation ; Applied Linguistics ; Communication Studies ; Multilingualism ; Educational Theory ; Educational Linguistics ; Education ; Bilingualism ; Intercultural ; Interpreting Studies ; Language Learning ; Language Education ; Deaf Education ; Sign Language ; Teacher Training ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics
    Language: English
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    Schulisch-berufliche Übergänge im Kontext von Inkl usion (2022)
    wbv Media | wbv Media
    Details
    Publication Date: 2024-03-29
    Description: Untersucht werden Bedingungsfaktoren für einen erfolgreichen Übergang von der Schule in den Beruf bei Jugendlichen mit den Förderschwerpunkten "Lernen" und "geistige Entwicklung". In der Dissertation wird der Einstieg ins Erwerbsleben aus Sicht der Betroffenen rekonstruiert. Dabei wird sichtbar, wie sehr diese Phase von persönlichen Erfahrungen mit der eigenen Beeinträchtigung geprägt ist. Die komplexen Übergangs- und Wechselprozesse können überfordernd wirken und zu Bildungs- und Entwicklungsverzögerungen führen. Die Autorin erläutert zunächst die Diskussion über inklusionsbezogene Teilhabe und die Umsetzung im (Berufs-)Bildungsbereich sowie am Arbeitsmarkt. Ergänzend fasst sie den Forschungs- und Erkenntnisstand zu schulisch-beruflichen Übergängen zusammen. Im empirischen Teil wertet sie die erhobenen Daten unter Anwendung inhaltsanalytischer Gütekriterien aus, die sie vor dem Hintergrund des Forschungsprozesses reflektiert.
    Keywords: Education ; Special Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs ; thema EDItEUR::J Society and Social Sciences::JN Education::JNS Teaching of students with different educational needs
    Language: German
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    Marine Natural Products as Anticancer Agents 2.0 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
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    Student Misconceptions and Errors in Physics and Mathematics (2021)
    Springer Nature
    Details
    Publication Date: 2021-02-10
    Description: This open access report explores the nature and extent of students’ misconceptions and misunderstandings related to core concepts in physics and mathematics and physics across grades four, eight and 12. Twenty years of data from the IEA’s Trends in International Mathematics and Science Study (TIMSS) and TIMSS Advanced assessments are analyzed, specifically for five countries (Italy, Norway, Russian Federation, Slovenia, and the United States) who participated in all or almost all TIMSS and TIMSS Advanced assessments between 1995 and 2015. The report focuses on students’ understandings related to gravitational force in physics and linear equations in mathematics. It identifies some specific misconceptions, errors, and misunderstandings demonstrated by the TIMSS Advanced grade 12 students for these core concepts, and shows how these can be traced back to poor foundational development of these concepts in earlier grades. Patterns in misconceptions and misunderstandings are reported by grade, country, and gender. In addition, specific misconceptions and misunderstandings are tracked over time, using trend items administered in multiple assessment cycles. The study and associated methodology may enable education systems to help identify specific needs in the curriculum, improve inform instruction across grades and also raise possibilities for future TIMSS assessment design and reporting that may provide more diagnostic outcomes.
    Keywords: Education ; International education  ; Comparative education ; Assessment ; Science education ; Mathematics ; Physics ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKD Examinations & assessment ; bic Book Industry Communication::J Society & social sciences::JN Education::JNU Teaching of a specific subject ; bic Book Industry Communication::P Mathematics & science::PB Mathematics ; bic Book Industry Communication::P Mathematics & science::PH Physics
    Language: English
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    Initiatives to Improve Quality of Education in the Kurdistan Region—Iraq (2023)
    RAND Corporation
    Details
    Publication Date: 2024-03-29
    Description: RAND supported the Kurdistan Regional Government in its aims to restructure its Ministry of Education, develop a plan for a school quality assurance system, review effectiveness of monitoring and support of private schools, and assess the quality of in-service teacher training. RAND researchers conducted interviews, reviewed literature, examined case studies in other countries, provided analysis, and developed implementation guidelines.
    Keywords: Education ; History ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMT Teacher training ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history::HBJF1 Middle Eastern history ; thema EDItEUR::J Society and Social Sciences::JN Education::JNK Educational administration and organization ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education::JNMT Teacher training ; thema EDItEUR::N History and Archaeology::NH History::NHG Middle Eastern history
    Language: English
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    Communicating Medicine (2021)
    Ledizioni
    Details
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
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    Open and Distance Education in Asia, Africa and the Middle East (2021)
    Springer Nature
    Details
    Publication Date: 2024-03-29
    Description: This book is open access under a CC BY 4.0 license. This book describes the history, structure and institutions of open and distance education in six countries: China, India, Russia, Turkey, South Africa and South Korea. It describes how open and distance education is evolving in a digital age to reflect the needs and circumstances of the national higher education systems in these countries. It also explores the similarities and differences between how their open and distance higher education systems are managed and structured. This book is the second in a series, following Open and Distance Education in Australia, Europe and the Americas (Springer 2018). Both books compare and draw conclusions about the nature of open and distance education in the context of various national higher education systems. In a digital era characterized by the growing use of online, open and distance education, this book will prove particularly valuable for policy-makers and senior administrators who want to learn about establishing or expanding open and distance education services. In addition, it offers a valuable reference guide for researchers, academics and students interested in understanding the different approaches to open and distance education.
    Keywords: Education ; Learning ; Instruction ; Educational technology ; International education  ; Comparative education ; Higher education ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNT Teaching skills & techniques ; bic Book Industry Communication::J Society & social sciences::JN Education::JNV Educational equipment & technology, computer-aided learning (CAL) ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNT Teaching skills and techniques ; thema EDItEUR::J Society and Social Sciences::JN Education::JNV Educational equipment and technology, computer-aided learning (CAL)
    Language: English
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    Collaborative Curriculum Design for Sustainable Innovation and Teacher Learning (2021)
    Springer Nature
    Details
    Publication Date: 2024-03-25
    Description: This open access book provides insight into what it takes to actively involve teachers in the curriculum design process. It examines different aspects of teacher involvement in collaborative curriculum design, with specific attention to its implications for sustainable curriculum innovation and teacher learning. Divided into six sections, the book starts out by introducing the notion of collaborative curriculum design and discusses its historical and theoretical foundations. It describes various approaches commonly adopted to actively involve teachers in the (co-)design of curriculum materials. Sections two and three provide examples of what key phases in the curriculum design process - such as needs analysis, design and development, and implementation - look like across various collaborative curriculum design projects. Section four reports on the impact of collaborative curriculum design on student learning, teacher practices, teacher professional growth, and institutional change. Building on the research evidence about the outcomes of collaborative curriculum design, section five focuses on sustainability, scaling-up and curriculum leadership issues, which are key to the continuation and further evolution of curriculum innovations. Future perspectives are addressed in section six with emphasis on the infrastructure of a sustainable curriculum innovation.
    Keywords: Education ; Curriculums (Courses of study) ; Education—Curricula ; Teaching ; Educational technology ; International education  ; Comparative education ; Professional education ; Vocational education ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JN Education::JND Educational systems and structures::JNDG Curriculum planning and development ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education::JNMT Teacher training ; thema EDItEUR::J Society and Social Sciences::JN Education::JNR Careers guidance::JNRV Industrial or vocational training ; thema EDItEUR::J Society and Social Sciences::JN Education::JNV Educational equipment and technology, computer-aided learning (CAL)
    Language: English
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    Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Lipid Signaling in T Cell Development and Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
    Language: English
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    Foundations of Paleoparasitology (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: English
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    Advances in the Diagnosis and Treatment of Thyroid Carcinoma (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-10-25
    Description: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Keywords: thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Kita-Entwicklung – Organisationsentwicklung als Chance für die frühe Bildung (2023)
    Verlag Barbara Budrich
    Details
    Publication Date: 2024-03-29
    Description: Wie kann Organisationsentwicklung zu verbesserter Kita-Qualität führen? Der Band stellt zwei von vier im Projekt "Forum KITA-Entwicklung" entstandene Expertisen vor, die sich mit dieser Frage beschäftigen. Insgesamt legen die Ergebnisse nahe, dass Organisationsentwicklung gewinnbringend für den Bereich Kita sein kann. Dazu sollten die Einrichtungen als in einem System verortet betrachtet werden.
    Keywords: Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNL Schools::JNLA Pre-school & kindergarten ; thema EDItEUR::J Society and Social Sciences::JN Education::JNL Schools and pre-schools::JNLA Pre-school and kindergarten
    Language: German
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    The Role of Technology in Improving K-12 School Safety (2023)
    RAND Corporation
    Details
    Publication Date: 2024-03-29
    Description: The report categorizes school safety technologies, noting the lack of research about school safety technology and summarizing the existing research on school violence; presents six case studies of innovative technologies used in schools; and summarizes experts’ views of technologies and safety problems, determined through interviews; and presents experts’ rankings of technology needs to improve school safety, produced during two day-long panels.
    Keywords: Sociology ; Law ; Psychology ; Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNF Criminal law & procedure::LNFQ Juvenile criminal law ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMC Child & developmental psychology ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNF Criminal law: procedure and offences::LNFQ Juvenile criminal law ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMC Child, developmental and lifespan psychology
    Language: English
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    Biomedical Insights that Inform the Diagnosis of ME/CFS (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
    Language: English
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    The Challenges of COVID-19 with Obesity-Related Cancers (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    The Schistosomiasis Vaccine - It Is Time to Stand Up (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.
    Keywords: R5-920 ; RC581-607 ; Schistosomiasis ; Schistosoma mansoni ; Schistosoma haematobium ; Type 2 cytokines ; Vaccine ; Immune responses ; Schistosoma japonicum ; Vaccine candidates ; bic Book Industry Communication::M Medicine
    Language: English
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    Allergic Rhinosinusitis and Airway Diseases (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-20
    Description: This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
    Keywords: chronic rhinosinusitis ; B-cell lymphoproliferative disorder ; sinus ; nasal allergies ; tannery worker ; Kanpur ; asthma ; ovalbumin ; saffron ; salbutamol ; IL’s ; TNF-α ; allergic rhinitis ; bronchial asthma ; allergy ; Th17 cells ; IL-17 ; IL-33 ; microRNA ; miR ; airway mucosal inflammation ; united airway disease ; acute rhinosinusitis ; acute recurrent rhinosinusitis ; Mediterranean diet ; nutritional evaluation ; nutritional therapy ; olfactory dysfunction ; anosmia ; post-acute COVID-19 ; nitric oxide ; NO ; exhaled NO ; FENO ; nasal peak flow ; atopic status ; total IgE ; specific IgE ; childhood asthma ; immunoblot ; ImmunoCAP ; otolaryngology ; sinusitis ; ethnic groups ; patient-reported outcome measures ; quality of life ; social justice ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Less and Non-invasive Hemodynamic Monitoring Techniques (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: In the perioperative setting and in intensive care medicine, early and effective hemodynamic management including fluid therapy and administration of vasoactive drugs to maintain vital organ perfusion and oxygen delivery is mandatory. Understanding the different approaches in the management of critically ill patients during the resuscitation and further management is essential to initiate adequate context- and time-specific interventions. Optimization of hemodynamic variables to achieve a balance between organ oxygen delivery and consumption is a cornerstone. In general, cardiac output (i.e., the blood flow) is considered a major determinant of oxygen supply and thus its monitoring is regarded helpful. However, indicators of oxygen requirements are equally necessary to assess adequacy of oxygen supply. Currently, more and more less or even totally non-invasive monitoring systems have been developed and clinically introduced, but they require validation in particular clinical settings. Cardiac output monitors and surrogates of organ oxygenation only enable to adequately guide management, as patient’s outcome is determined by acquisition and interpretation of accurate measurements, and finally, suitable management decisions. This Research Topic focuses on the currently available techniques, especially the less and non-invasive ones, in the field of hemodynamic monitoring in the perioperative setting and in critically ill patients while summarizing their advantages and limitations.
    Keywords: R5-920 ; Blood Pressure ; Cardiovascular dynamics ; goal-directed therapy ; intensive care medicine ; Cardiac Output ; Anesthesiology ; bic Book Industry Communication::M Medicine
    Language: English
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    Model-Informed Precision Dosing (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
    Keywords: model-informed precision dosing (MIPD) ; efficacy PKPD indexes ; pharmacokinetics ; pharmacodynamics ; PKPD modeling and simulation ; dosing algorithms ; nomograms ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-09-11
    Description: Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented.
    Keywords: ferulic acid ; total body irradiation ; bone marrow microenvironment ; stem cell senescence ; bone marrow injury ; reactive oxygen species ; antioxidant defense system ; planarians ; model animal ; irradiation ; regeneration ; radioprotection ; radiation ; melatonin ; nDNA-repair ; mtDNA-mutations ; oxidation stress ; protection ; mitigation ; H2O2 ; ATP ; MDA ; GSH ; X-ray radiation ; 3T3 fibroblasts ; proliferation ; apoptosis ; cellular stress ; senescence ; peroxiredoxin 6 ; Prdx6 ; radioprotector ; pharmacologic ascorbate ; vitamin C ; pancreatic cancer ; Auranofin ; thioredoxin ; thioredoxin reductase ; peroxiredoxin ; nuclear and radiological emergencies ; radioprotectors ; radiomitigators ; radionuclide scavengers ; radiation biodosimetry ; Olea europaea L. cv. Caiazzana ; oleacein ; ionising radiation ; cancer ; radiotherapy ; normal tissue ; radiosensitization ; radiomodulation ; proteomic analysis ; oxidative modification profiling ; serum albumin ; amino acid sequences ; radiation biomarker ; human lactoferrin ; acute gamma irradiation ; C57Bl/6 mice ; survival rate ; open field test ; spleen ; serum homeostasis ; leukocytes ; stilbenoid ; electron paramagnetic resonance (EPR) ; FT-IR ; electron beam radiation ; radioresistance ; oxidative phosphorylation ; oncometabolites ; radiation response ; bioinformatics ; oxidative stress ; transcriptomics ; radiobiology database ; gene signature ; ionizing radiation ; intestine ; mucositis ; microbiome ; microbiota ; dysbiosis ; bacterial dietary supplement ; radiomitigator ; hyperthermia ; combination therapy ; synergistic effect ; oxygenation ; hypoxia ; immune response ; Tameron ; antioxidant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    City of the Future Graduation Lab (2023)
    TU Delft OPEN Publishing
    Details
    Publication Date: 2024-03-23
    Description: The Cross Domain City of the Future Graduation Lab, situated in the Faculty of Architecture and the Built Environment at TU Delft, has been a pioneer in experimenting with a multidisciplinary approach to education on the built environment. Drawing upon this expertise over the past years, this book reflects on multidisciplinarity in the built environment and its implementation in education on the built environment. How should one approach multidisciplinarity in education and practice? What encompasses its core elements, benefits, and challenges? By addressing these questions, the book aims to inform students and practitioners within the realm of the built environment by sharing insights from experiences in multidisciplinary education. It presents eight conclusions regarding the future of multidisciplinary education and, thereby, seeks to contribute to a more humane and sustainable future for cities: 1.Process is central to multidisciplinary collaboration. Negotiating positions, ensuring an environment of respect, balance and open-mindedness, and setting a common vocabulary. 2.Multidisciplinarity can be a way to foster innovation. It triggers complementarity and confrontation. As with any innovation, there is potential for greater outcomes, but, at the same time, extra risks emerge. These need to be managed. 3.Multidisciplinarity could be better integrated into organisational structures. 4.Disciplinarity and multidisciplinarity are in mutual coexistence. They are inseparable. They can complement and contradict each other. 5.Problem precedes solution, not the opposite. Framing the problem, or ‘problematizing’, is a considerable share of the actual solution. This is particularly applicable to multidisciplinarity. 6.Multidisciplinarity is by nature composed of fluid boundaries. Navigating through an enormous diversity of perspectives requires agility, flexibility, independence, spirit of adventure and embracing uncertainty. 7.Professionals should be trained as ‘T-shape’: grounded in their field while able to dialogue with other fields. 8.Both generalists and specialists are needed. Education should provide opportunities for both.
    Keywords: City ; Future ; Multidisciplinarity ; Design ; Education ; Engineering ; Graduation Lab ; Built Environment ; Architecture ; Urban Design ; Management ; Geomatics ; Transport ; Infrastructure ; Logistics ; Collaboration ; thema EDItEUR::A The Arts::AM Architecture
    Language: English
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    Personalized medicine, individual choice and the common good (2022)
    Cambridge University Press
    Details
    Publication Date: 2022-02-11
    Description: law; medicine; medico legal; bioethics and health law; ethics; philosophy
    Keywords: law; medicine; medico legal; bioethics and health law; ethics; philosophy ; bic Book Industry Communication::L Law ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bio-ethics ; bic Book Industry Communication::H Humanities::HP Philosophy
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    Large-Scale Cognitive Assessment (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2021-02-10
    Description: This open access methodological book summarises existing analysing techniques using data from PIAAC, a study initiated by the OECD that assesses key cognitive and occupational skills of the adult population in more than 40 countries. The approximately 65 PIAAC datasets that has been published worldwide to date has been widely received and used by an interdisciplinary research community. Due to the complex structure of the data, analyses with PIAAC datasets are very challenging. To ensure the quality and significance of these data analyses, it is necessary to instruct users in the correct handling of the data. This methodological book provides a standardised approach to successfully implementing these data analyses. It contains examples of and tools for the analysis of the PIAAC data using different statistical approaches and software, and it offers perspectives from various disciplines. The contributing authors have hands-on experience of using PIAAC data, and/or they have conducted data analysis workshops with these data.
    Keywords: Assessment, Testing and Evaluation ; Statistics for Social Sciences, Humanities, Law ; Education Economics ; International and Comparative Education ; Education ; Statistics in Social Sciences, Humanities, Law, Education, Behavorial Sciences, Public Policy ; PIAAC data ; Large-scale assessment ; Data analysis ; Plausible values ; International comparison ; Key cognitive skills ; Literacy of adult population ; Numeracy of adult population ; Analysis with PIAAC datasets ; Stata ; R software ; Open access ; Education: examinations & assessment ; Social research & statistics ; Economics of specific sectors ; bic Book Industry Communication::J Society & social sciences::JN Education::JNK Organization & management of education::JNKD Examinations & assessment ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBC Social research & statistics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: English
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    International Reflections on the Netherlands Didactics of Mathematics (2021)
    Springer Nature
    Details
    Publication Date: 2024-04-06
    Description: This open access book, inspired by the ICME 13 Thematic Afternoon on “European Didactic Traditions”, takes readers on a journey with mathematics education researchers, developers and educators in eighteen countries, who reflect on their experiences with Realistic Mathematics Education (RME), the domain-specific instruction theory for mathematics education developed in the Netherlands since the late 1960s. Authors from outside the Netherlands discuss what aspects of RME appeal to them, their criticisms of RME and their past and current RME-based projects. It is clear that a particular approach to mathematics education cannot simply be transplanted to another country. As such, in eighteen chapters the authors describe how they have adapted RME to their individual circumstances and view on mathematics education, and tell their personal stories about how RME has influenced their thinking on mathematics education.
    Keywords: Education ; Mathematics—Study and teaching  ; Learning ; Instruction ; Teaching ; Assessment ; thema EDItEUR::J Society and Social Sciences::JN Education::JND Educational systems and structures::JNDH Education: examinations and assessment ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education::JNMT Teacher training ; thema EDItEUR::J Society and Social Sciences::JN Education::JNT Teaching skills and techniques ; thema EDItEUR::J Society and Social Sciences::JN Education::JNU Teaching of a specific subject
    Language: English
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    Blood-Derived Products for Tissue Repair/Regeneration (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
    Keywords: R5-920 ; RM1-950 ; n/a ; biomaterial ; redifferentiation ; regenerative medicine ; skeletal muscle regeneration ; furcation defects ; Platelet-Rich Plasma (PRP) ; PRP ; fracture ; fibrin sealant ; periodontal surgery ; bone regeneration ; serum derived from plasma rich in growth factors (s-PRGF) ; cartilage repair ; myofibroblasts ; autologous platelet concentrates ; burns ; satellite cells ; articular cartilage ; stem cell niche ; wound healing ; quantification ; growth factors ; biologics ; platelet rich plasma ; meniscus ; adipose tissue ; Carprofen ; platelet-rich fibrin ; platelets ; hyperacute serum ; bone defects ; serum eye drops ; corneal epithelial defect ; fibrosis ; dog ; myoblasts ; differentiation ; chronic meniscal lesion ; horizontal meniscal tear ; PRGF ; collagen hydrogels ; periodontal defects ; bone grafting material ; composition ; cell therapy ; bone healing ; tissue healing ; trephination ; plasma rich plasma (PRP) ; bone repair ; plasma rich in growth factors ; knee arthrosis ; meniscus tear ; cornea regeneration ; wrist osteoarthritis ; periosteal sheet ; Platelet-Poor Plasma (PPP) ; platelet-rich plasma ; microfat ; bone grafting ; hyaluronic acid (NaHA) ; periodontal regeneration ; meniscus repair ; photobiomodulation therapy ; growth ; myogenesis ; blood derived products ; low-level laser therapy ; bic Book Industry Communication::M Medicine
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    Arbeitsorientierte Grundbildung und Alphabetisierung (2021)
    wbv Media | wbv Media
    Details
    Publication Date: 2023-02-01
    Description: Die arbeitsplatzorientierte Grundbildung etabliert sich als Forschungsfeld in der Erwachsenenbildungswissenschaft. Im Sammelband werden Grundfragen zu Institutionalisierung, Professionalisierung und Kompetenzentwicklung der Teilnehmenden diskutiert. Grundlage des Bandes sind aktuelle Forschungsergebnisse aus dem Projekt Arbeitsplatzbezogene Alphabetisierung und Grundbildung Erwachsener (ABAG²). Die Beiträge befassen sich mit den Themen Grundbildungsverständnis ebenso wie mit Konzepten zur Erweiterung von Schlüsselqualifikationen, dem Ausbau von Kompetenzen bei Lehrenden der Weiterbildung, pädagogischen Handlungskompetenzen und Effekten der Teilnahme.
    Keywords: Education ; Vocational ; bic Book Industry Communication::J Society & social sciences::JN Education::JNR Careers guidance::JNRV Industrial or vocational training
    Language: German
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    Ventricular Mechanics in Congenital Heart Disease (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Looking at "Horse in Motion", the iconic photograph by E. Muybridge, it is almost possible to hear the horse galloping. The pounding sound of the hoofs hitting the ground -like a drum- can also echo the rythmic beating of the human heart. That sound, that visceral rhythm, reminds us of the link between motion and performance: the perfectly executed stride of the horse, the incredible coordination of multiscale phenomena behind a heart beat. Furthermore, the decomposed sequence in Muybridge's photograph has become a well-known example of breaking motion into its components over time, and as such is reminiscent of those images that are routinely acquired in clinical practice, where the heart appears dilating and shirnking in a sequence of snapshots. The investigation of this motion and its subtleties is essential for refining our understanding of cardiac function, and the appreciation of how and when this motion is no longer perfectly executed can lead us to understand functional impairments and provide insight into the unfolding of pathology. In the presence of congenital heart disease (CHD), cardiac mechanics are altered: from single ventricle physiology to conduction abnormalities to different cardiomyopathies, it is important to both capture and interpret biomechanical changes that occur in the presence of a congenital defect. This special issue in Frontiers in Pediatrics, now an e-book, focuses on 'Ventricular mechanics in congenital heart disease' and looks at current knowledge of phenomena such as systolic/diastolic dysfuction and current methods (chiefly in cardiovascular magnetic resonance imaging and echocardiography) to evaluate cardiac function in the presence of CHD, and then presents a series of original studies that employ both medical imaging and computational modelling techniques to study specific CHD scenarios.
    Keywords: R5-920 ; RJ1-570 ; cardiovascular magnetic resonance imaging ; ventricular mechanics ; Congenital Heart Diseases ; hypoplastic left heart syndrome ; diastolic function ; computational modelling ; systolic function ; haemodynamics ; bic Book Industry Communication::M Medicine
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    Clinical Advances in Chronic Intestinal Diseases Treatment (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-05-06
    Description: Chronic intestinal diseases are increasing around the world. With poor quality of life and expensive healthcare costs, the patients demand novel approaches and treatments for better clinical outcomes. This book illustrates the state of the art and the envisaged near future in the management of these pathologies.
    Keywords: chronic intestinal pseudo-obstruction ; parenteral nutrition ; pediatrics ; myopathy ; neuropathy ; IBS ; microbiota ; visceral hypersensitivity ; colorectal motility ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; anti-TNF ; ustekinumab ; vedolizumab ; postoperative complications ; surgery ; preoperative therapy ; biologic therapy ; bio-naïve ; IBD ; pro-inflammatory cytokines ; lymphocyte migration ; treatment ; inflammatory bowel diseases ; biologic treatment ; combination ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Assessing Atmospheric Pollution and Its Impacts on the Human Health (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases.
    Keywords: household air pollution ; fine particulate matter ; international environmental health ; cookstove ; respiratory disease ; brick worker ; particulate matter ; heavy metals ; Sulfate-Nitrate-Ammonium ; pollution levels ; mobile sources ; aerosols ; PAHs ; OC and EC ; transport sources ; urbanized coastal station ; grain dust ; health risk assessment ; Monte Carlo simulation ; disability adjusted life year ; multi-media exposure ; health risk ; probabilistic risk assessment ; Lake Chaohu ; PM10 ; health risks ; extreme learning machine ; echo state network ; neural networks ; pollution ; concentration ; indicators ; aberrant values ; nitrogen oxides ; ARIMA ; GRNN ; ARIMA–GRNN ; isolation forest ; LOF ; AOD ; classification ; dendrogram ; PCA ; air quality index ; polluting agents ; respiratory diseases ; monitoring stations ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
    Language: English
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    Weiterbildungspartizipation und Bildungsurlaub (2021)
    W. Bertelsmann Verlag | W. Bertelsmann Verlag
    Details
    Publication Date: 2023-02-01
    Description: In der Dissertation wird die Theorie und Forschung zur Weiterbildungsbeteiligung aufgearbeitet und ""Bildungsurlaub"" als Forschungsfeld für die Erwachsenenbildung erschlossen. Die Autorin präsentiert theoretische Grundlagen, rechtliche Rahmenbedingungen, Diskurslinien und Befunde aus 50 Jahren Bildungsurlaub in der Bundesrepublik Deutschland. Für die Auswertung und Analyse ihrer Studie zur Teilnahme an Bildungsurlaubsangeboten im Bundesland Bremen nutzt die Autorin grundlegende Erkenntnisse der Forschung zur Weiterbildungspartizipation. Im Ergebnis identifiziert die Autorin folgende Bedingungsfaktoren für die Teilnahme an Weiterbildung: das Zusammenspiel von Kontextfaktoren und Gelegenheitsstrukturen, Individualfaktoren sowie subjektive Sinn- und Bedeutungszuschreibungen. Die anschließende systematische Zusammenführung mit den Studienbefunden ist die Grundlage für weitere Forschungen zum Bildungsurlaub. Die Dissertation ist ein wichtiger Beitrag zur bildungswissenschaftlichen Grundlagenforschung und rückt den Bildungsurlaub als besonderen Teil der Weiterbildungslandschaft in den Blick.
    Keywords: Education ; Adult & Continuing Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNP Adult education, continuous learning
    Language: German
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    Technology in Rehabilitative Interventions for Children (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-06-21
    Description: This Special Issue is aimed to offer an overview of studies presenting new rehabilitation approaches addressed to children with neurodevelopmental disorders, designed to enhance the effects of learning processes through the use of new technologies. The contributions of this Special Issue, authored by researchers and clinicians from some of the most valued Italian scientific institutions in the field of neurodevelopmental disorders, can offer some useful data and advice on the use of technology in rehabilitation and telerehabilitation to researchers, rehabilitators, clinicians and pratictioners (psychologists, neuropsychologists, speech therapists, etc.).
    Keywords: neurorehabilitation ; cognitive enhancement in children ; tech mediated rehabilitation ; developmental coordination disorders ; virtual reality ; telerehabilitation ; specific learning disorders ; cerebral palsy ; well-being ; dyslexia ; rhythm ; music therapy ; intervention ; developmental dyslexia ; new technologies ; augmented reality ; good practices ; Delphi method ; rehabilitation ; remote intervention ; children ; age ; severity ; improvement ; follow-up ; n/a ; bic Book Industry Communication::M Medicine
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    Personalized Nursing and Health Care (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-05-11
    Description: There has been a rapid development in the academic literature over the last ten years on papers relating to individualization, personalization, patient-, client-, consumer- and person-centredness, with work on conceptual, instrumental, observational, and experimental levels. This Special Issue presents papers that can further establish the current state of science on these topics relating to personalized nursing and health care. We collected papers that highlight and further the knowledge base conceptually, instrumentally, observationally, and experimentally with sound theoretical and methodological underpinnings and implications for research, theory, and clinical work in the disciplines of nursing, medicine, allied health, and beyond.
    Keywords: anxiety ; life satisfaction ; life–work concerns ; melatonin ; cortisol ; biopsychosocial model ; obstetric complications ; patients’ rights ; student ; nursing ; personalized medicine ; HIV ; mobile health ; smartphone application ; symptom management ; nurse practitioners ; nursing home ; COVID-19 ; palliative care ; end-of-life ; dignified death ; older adults ; accidental falls ; fall prevention ; barriers ; patient compliance ; music therapy ; dementia ; caregiver ; RCT ; patient-centred care ; competence ; assessment ; instrument ; measurement ; validity ; reliability ; individual care ; nurses ; older diabetes patients ; physicians ; support ; Parkinson’s disease ; nursing training ; integrated care ; Parkinson nurse ; personalized care ; multidisciplinary care ; patient-centered ; arthritis ; autoimmune disease ; sociopsychological factors ; emotion ; depression ; self-identity ; qualitative study ; observational study ; dysmenorrhea ; kinesio tape ; auricular acupressure ; pain ; nursing care ; patient care planning ; quality of health care ; conditional inference trees ; education ; distance ; learning ; digital ; drawings ; Nigeria ; perinatal loss ; social networks ; stillbirth ; stillborn ; functional status ; health care ; hospitalization ; activities of daily living ; pelvic floor muscle exercises ; pelvic floor dysfunction ; qualitative research ; therapeutic exercise ; therapeutic adherence ; women’s health physiotherapy ; diabetes mellitus type 2 ; prediction model ; LogicRegression ; interpretability ; pelvic organ prolapse ; lifestyle changes ; women’s experience ; n/a ; foot ; foot self-care ; methodological review ; bic Book Industry Communication::M Medicine
    Language: English
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    Transforming an Urban School System (2023)
    RAND Corporation
    Details
    Publication Date: 2024-03-29
    Description: In the 2010–2011 school year, two educational programs launched in New Haven, Connecticut: New Haven School Change, a sweeping K–12 educational reform to improve the learning of educational outcomes of its students, and New Haven Promise, a scholarship program intended to improve college-going culture and encourage graduates to attend college. This report documents a study of early progress in these programs.
    Keywords: Education ; History ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNL Schools::JNLC Secondary schools ; bic Book Industry Communication::J Society & social sciences::JN Education::JNS Teaching of specific groups & persons with special educational needs::JNSV Teaching of students with English as a second language (TESOL) ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJK History of the Americas ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education ; thema EDItEUR::J Society and Social Sciences::JN Education::JNL Schools and pre-schools::JNLC Secondary schools ; thema EDItEUR::J Society and Social Sciences::JN Education::JNU Teaching of a specific subject ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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    Innovative Pasta with High Nutritional and Health Potential (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-03-07
    Description: Dry pasta is one of the most popular staple foods worldwide due to its convenience in terms of affordability, versatility, long shelf life, as well as sensory and nutritional value. As such, it represents a suitable carrier for health-promoting substances providing specific physiological functions. This Special Issue deals with the continuum aspects, “from seed to fork”, that could have an impact on the nutritional, sensory, and technological aspects of pasta. In this Special Issue, we aimed to publish innovative research and review papers on physico-chemical and sensorial characteristics, nutritional value, functional and technological properties of pasta, and pasta-making processes. New raw materials, new functional ingredients, up-cycling of waste materials, in vivo experiments to test the effect of assumption of the supplemented pasta, and innovative packaging systems will also be addressed in this Special Issue. Predictions of pasta quality adopting chemometrics as well as multi-variate and statistical data analysis approaches were welcomed. Finally, in the medium term, the international pasta market is expected to stay negative unless tangible product innovations are introduced, particularly regarding the technological innovations aimed at improving the products’ health benefits. This Special Issue aimed to provide a fundamental understanding and present the current strategies to improve the technological, nutritional, and sensory properties of pasta.
    Keywords: innovative pasta raw materials ; durum ; emmer ; spelt ; pasta ; brewers’ spent grain ; dietary fiber ; einkorn ; functional pasta ; tritordeum ; upcycling ; unconventional ingredients ; nutritional value ; cooking quality ; legumes ; Spirulina Platensis ; resistant starch ; hydrolysis index ; dietary fibre ; annealing ; slowly digestible starch ; carbohydrates ; fiber ; in vitro digestion ; micronization ; brown rice ; air fractionation ; parboiling ; rice pasta ; enriched pasta ; bioactive compound ; tuna ; sea bass ; Ω-3 fatty acids ; sensometrics ; TPA (texture profile analysis) ; glycemic index ; glycemic response ; durum wheat ; landraces ; starch ; available carbohydrates ; glycemic load ; texture profile analysis ; gluten-free ; celiac disease ; fish ; allergy ; pear, date, and apple by-products ; wheat flour ; sensorial properties ; scanning electron microscopy ; multiple factor analysis ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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    Self-Reported Population Health: An International Perspective based on EQ-5D (2021)
    Springer Nature
    Details
    Publication Date: 2023-01-13
    Description: Biomedicine general; Public Health; Quality of Life Research; Population Health; EQ-5D; Quality-of-Life; Utilities
    Keywords: Biomedicine general ; Public Health ; Quality of Life Research ; Population Health ; EQ-5D ; Quality-of-Life ; Utilities ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine ; bic Book Industry Communication::T Technology, engineering, agriculture::TC Biochemical engineering
    Language: English
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    Standards-Based Accountability Under No Child Left Behind (2023)
    RAND Corporation
    Details
    Publication Date: 2023-10-05
    Description: Since 2001-2002, standards-based accountability provisions of the No Child Left Behind Act of 2001 have shaped the work of public school teachers and administrators in the United States. This book sheds light on how accountability policies have been translated into actions at the district, school, and classroom levels in three states.
    Keywords: Sociology ; Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSP Age groups::JFSP1 Age groups: children
    Language: English
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    Natural Antibodies in Health and Disease (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behaving as regulatory elements in acute or chronic inflammation. To maintain the non-pathogenic balance between the dual pathogen/self-antigen cross-reactivities of NAbs, a strict regulation in NAb secretion and function is necessary to avoid autoimmune disease. Actually, some of the NAbs related auto-reactivities, such as anti-DNA and anti-MOG, have been associated with autoimmunity. Furthermore, NAbs have been shown to bind to ‘neo-self’ carbohydrate antigens on glycolipids and glycoproteins found on malignant but not normal cells, which suggests NAbs may take part in tumor immunosurveillance. Many aspects regarding NAbs have yet to be studied in more detail: the reactivity and function of NAbs in health and disease, the behavior of the NAb repertoire with increasing age, the regulation of natural antibody production and auto-reactivity, the ways to specifically activate NAbs producing cells with desired specificities, the characteristics of human NAbs, among others. This special topics eBook consists of a number of articles exploring the cells that produce NAbs as well as the characteristics, function, specificity, and/or the role of natural antibodies in health and disease.
    Keywords: R5-920 ; RC581-607 ; innate immunity ; immunoglobulin ; Antibodies ; B cells ; IgM ; natural antibodies ; B-1 cells ; bic Book Industry Communication::M Medicine
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    Homeostasis and Allostasis of Thyroid Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values.〈/p〉〈p〉A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. 〈/p〉〈p〉Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome.〈/p〉〈p〉A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment.〈/p〉〈p〉Considerable progress has been made in this respect in the following key areas:〈/p〉〈p〉• the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure,〈/p〉〈p〉• the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects,〈/p〉〈p〉• the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression,〈/p〉〈p〉• the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates,〈/p〉〈p〉• the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load.〈/p〉〈p〉This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
    Keywords: R5-920 ; RC648-665 ; relational stability ; Thyronamines ; TSH-T3 Shunt ; thyroid allostasis ; precision medicine ; Stratified Medicine ; 3-T1AM ; Hypothyroidism ; Thyroid homeostasis ; Hysteresis ; bic Book Industry Communication::M Medicine
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    New treatment perspectives in autism spectrum disorders (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways disrupted in the disease, thus contributing to identify novel drug targets.
    Keywords: R5-920 ; RJ1-570 ; Clinical Trial ; mouse model ; neurodevelopmental disorder ; Genetics ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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    Islamunterricht - Islamischer Religionsunterricht - Islamkunde (2021)
    transcript Verlag
    Details
    Publication Date: 2024-04-07
    Description: Die in diesem Band versammelten Aufsätze bieten Einblicke in die didaktische Diskussion zum Islamunterricht an öffentlichen Schulen in Deutschland. Hierzu werden Baden-Württemberg, Berlin, Niedersachsen und Nordrhein-Westfalen in einen gemeinsamen Untersuchungskontext gestellt. Die Analyse von Lehrplänen, die Unterrichtsbeobachtungen und Lehrergespräche zeigen große Unterschiede in der Konstruktion von Unterrichtsgegenständen sowie in der Interpretation von Bildungszielen auf und bieten eine Grundlage, um die Erfahrungen der Bundesländer erstmals in einer gemeinsamen Perspektive zu verknüpfen.
    Keywords: Islamunterricht ; Islam ; Didaktik ; Bildung ; Integration ; Interkultureller Dialog ; Islamwissenschaft ; Bildungspolitik ; Zivilgesellschaft ; Migration ; Education ; Islamic Studies ; Educational Policy ; Civil Society ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: German
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    Engineering a Better Future (2021)
    Springer Nature
    Details
    Publication Date: 2024-04-07
    Description: This open access book examines how the social sciences can be integrated into the praxis of engineering and science, presenting unique perspectives on the interplay between engineering and social science. Motivated by the report by the Commission on Humanities and Social Sciences of the American Association of Arts and Sciences, which emphasizes the importance of social sciences and Humanities in technical fields, the essays and papers collected in this book were presented at the NSF-funded workshop ‘Engineering a Better Future: Interplay between Engineering, Social Sciences and Innovation’, which brought together a singular collection of people, topics and disciplines. The book is split into three parts: A. Meeting at the Middle: Challenges to educating at the boundaries covers experiments in combining engineering education and the social sciences; B. Engineers Shaping Human Affairs: Investigating the interaction between social sciences and engineering, including the cult of innovation, politics of engineering, engineering design and future of societies; and C. Engineering the Engineers: Investigates thinking about design with papers on the art and science of science and engineering practice.
    Keywords: Education ; Technical education ; Technology—Sociological aspects ; Engineering design ; Management ; Industrial management ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JN Education::JNM Higher education, tertiary education ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas::KJMV6 Research and development management ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBD Technical design
    Language: English
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    Spectroscopic, Thermodynamic and Molecular Docking Studies on Molecular Mechanisms of Drug Binding to Proteins (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated.
    Keywords: RSV ; ectodomain G protein ; heparan sulfate ; protein–ligand interaction ; fluorescence quenching ; molecular docking ; molecular dynamic simulation ; quercetin ; CCL4 ; neurotoxicity ; VirtualToxLab ; oxidative stress markers ; Huperzine A ; molecular dynamics simulation ; fluorescence spectroscopy ; human serum albumin ; neurodegenerative disorders ; drug–protein interactions ; erlotinib ; bovine serum albumin ; binding interaction ; competition ; hepatitis E virus ; methyltransferase ; protein stability ; enzyme assay ; garlic ; antioxidant ; anti-glycation ; glycation ; AGEs ; HSA ; quetiapine ; hydrophobic interaction ; thermodynamic parameters ; seproxetine ; antidepressant ; charge transfer ; π-acceptors ; DFT ; haloperidol ; antipsychotics ; keratoconus ; MMP-2 ; MMP-9 ; molecular dynamics ; MM-GBSA calculations ; pharmacophore mapping ; α-amylase ; advanced glycation end-products ; caffeic acid ; coumaric acid ; coronary artery disease ; phytotherapy ; network pharmacology ; angiogenesis ; zebrafish ; dynamics molecular docking ; NEK7 ; virtual screening ; DFTs ; deep learning ; drug design ; drug repurposing ; structural-based ; cancer ; A. aspera ; β-amyrin ; C. gigantea ; C. procera ; GC-MS ; Minimum inhibitory concentration (MIC) ; Molecular docking ; MD simulations ; Tuberculosis (TB) ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Die göttliche Weisheit des Hermes Trismegistos (2023)
    Mohr Siebeck | Mohr Siebeck GmbH & Co. KG
    Details
    Publication Date: 2024-01-18
    Description: Als aus dem Griechischen übersetzter Lehrdialog ist der lateinische Asclepius ein wichtiger Textzeuge des Hermetismus, einer geistigen Bewegung, die aus der Begegnung von Griechen und Ägyptern erwuchs und im 1. bis 4. Jahrhundert n. Chr. blühte. Ihr namengebender Lehrer ist Hermes Trismegistos. Im Asclepius belehrt er seinen Schüler Asclepius über die Natur Gottes und seiner Schöpfung und über die Stellung des Menschen in der Welt. Eingebunden ist ein apokalyptischer Passus, der den Untergang Ägyptens voraussagt. Der vorliegende Band enthält den lateinischen Text, eine Übersetzung mit Kommentar und sechs Aufsätze, die den Asclepius und den Hermetismus im Blick auf die ägyptisch-griechische Misch-Kultur ihrer Entstehungszeit, die platonische Philosophie, die Tradition apokalyptischer Literatur und die Nachwirkung in Mittelalter und Renaissance untersuchen. Text und Übersetzung einer fragmentarisch überlieferten koptischen Parallelversion sind beigefügt.
    Keywords: Education ; Higher ; History ; Ancient ; Language Arts & Disciplines ; Study & Teaching ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::H Humanities::HB History::HBL History: earliest times to present day::HBLA Ancient history: to c 500 CE ; bic Book Industry Communication::C Language::CJ Language teaching & learning (other than ELT)
    Language: German
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    Historisches Vergleichen (2022)
    Logos Verlag Berlin | Logos Verlag Berlin
    Details
    Publication Date: 2024-04-02
    Description: Dem Vergleichen wird in der Geschichtswissenschaft die Funktion einer historischen Methode zugesprochen, für den Geschichtsunterricht dient es als Methode zur Förderung historischer Kompetenzen. In den Geschichtslehrwerken der Sekundarstufe II taucht es in der Regel in Form von Aufgaben auf. Doch wie relevant sind Vergleichsaufgaben in Lehrwerken überhaupt und welche Fertigkeiten und Kompetenzen benötigen Lernende in der Sekundarstufe II zur (schriftlichen) Lösung einer historischen Vergleichsaufgabe? Diesen Fragen wird mit Hilfe einer zweiteiligen Untersuchung auf der Grundlage einer umfangreichen Frequenzanalyse von Aufgaben in Geschichtslehrwerken der Sekundarstufe II in NRW sowie einer Korpusanalyse von Lernendentexten zu einer authentischen Vergleichsaufgabe aus einem Geschichtslehrwerk nachgegangen. Die Arbeit verbindet den geschichtsdidaktischen Zugang mit dem linguistischen Ansatz der Funktionalen Pragmatik, um das Vergleichen als Handlungsmuster des Geschichtsunterrichts zu bestimmen und es im Hinblick auf seinen kommunikativen Zweck in Teilhandlungen aufzuschlüsseln. Der Zugang wird ergänzt durch den Bezug zur Schreibdidaktik, der gerade im Hinblick auf wissenschaftspropädeutisches Arbeiten in der Sekundarstufe II eine wichtige Rolle spielt. Aus den Ergebnissen der Untersuchungen wird auf der Grundlage eines Indikatorenmodells ein praxisorientierter Weg zum Umgang mit Vergleichsaufgaben im Geschichtsunterricht vorgeschlagen.
    Keywords: History ; Education ; Literary Criticism ; European ; German ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism
    Language: German
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