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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alone and in combination with new therapeutic approaches such as immunotherapies, for the management of cancer. Moreover, the results of clinical trials will likely profoundly affect the direction of the laboratory efforts that are going on in parallel and aiming to improve the personalization of this therapeutic strategy. This Special Issue is our attempt to cover the past and present clinical results that have brought us to this pivotal moment and will form the basis of future clinical developments. Scientists and clinicians caring for cancer patients are well aware of the challenges in dealing with this particular therapeutic approach; one such challenge is obtaining improvements in patient survival without significant toxicity. This edition includes clinical research on chemotherapy and ongoing controversies related to metronomic chemotherapy.
    Keywords: metronomic ; oral cancer ; oral squamous cell carcinoma ; metronomic chemotherapy ; metastatic castration-resistant prostate cancer ; cyclophosphamide ; side effects ; pediatric tumors ; etoposide ; valproic acid ; prostate cancer ; CRPC ; castration ; capecitabine ; paclitaxel ; immunomodulation ; angiogenesis ; microbiome ; breast cancer ; safety ; preclinical studies ; clinical studies ; pharmacokinetic studies ; biomarkers ; chemo-free ; DLBCL ; diffuse-large-b-cell-lymphoma ; elderly ; frail ; comprehensive geriatric assessment ; chemo-endocrine therapy ; FulVEC ; pediatric oncology ; brain tumors ; pharmacology ; medulloblastoma ; ATRT ; immunotherapy ; lymphoma ; vinorelbine ; checkpoint inhibitors ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This collection of articles provides insight into the mental health and nursing care of individuals who are confronting a life-threatening illness. As individuals face a cancer diagnosis, there will be many challenges and changes in their lives. Emotional distress can emerge to greater and lesser degrees. Frequently, these individuals will require additional assistance to cope with the emotional distress they experience. Nurses have an important role in assessing this emotional distress and providing relevant interventions.
    Keywords: Latinx ; family ; meaning ; communication ; coping with advanced cancer ; delirium ; liaison nurse ; misrecognition of delirium ; coordination ; breast cancer ; psychological distress ; quality of life ; women’s health ; qualitative study ; cancer care ; older adults ; mental health ; feeling safe ; home-dwelling ; patients with terminal cancer ; caregivers ; competency in anticipatory grief counseling ; emotional care ; person-centered care ; qualitative research ; anxiety ; depression ; family involvement ; hepatocellular carcinoma ; palliative care ; cancer ; decision-making ; nurse ; caregiving self-efficacy ; family caregiver ; oral cancer ; oncology ; nursing ; clinical nurse specialists ; cancer patients ; expanding nurses’ authority ; professionalization ; policy ; education ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Obstructive sleep apnea is a highly prevalent disorder with strong associations with cardiovascular, cerebrovascular, metabolic, and cognitive consequences, including drowsy driving. Positive Airway Pressure treatment is the first-line therapy for adults with obstructive sleep apnea who are symptomatic. However, many individuals with comorbidities do not report symptoms that are associated with the disorder, and adherence to treatment is poor, especially in individuals with cardiovascular diseases. This reprint contains reviews and original articles that aim to update the current perspectives on the treatment modalities of obstructive sleep apnea to highlight multidisciplinary approaches, personalized treatment strategies, and the identification of the predictors of a patient’s response to treatment, both in the general population and in clinical cohorts.
    Keywords: obstructive sleep apnea (OSA) ; continuous positive airway pressure (CPAP) ; mandibular advancement devices ; upper airway surgery ; drowsy driving ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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  • 5
    Publication Date: 2024-01-08
    Description: Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimizing biological treatment in patients with inflammatory bowel disease (IBD) and other immune-mediated inflammatory diseases (IMID). Reactive TDM has rationalized the management of primary non-response and secondary loss of response to biologics, while cumulative evidence suggests that proactive TDM is efficacious for optimizing anti-tumour necrosis factor (anti-TNF) therapy in patients with IBD. Proactive TDM can be very useful for optimizing biological therapy in specific IBD populations, such as pregnant women as well as patients with perianal fistulizing Crohn’s disease and acute severe ulcerative colitis who are characterized by high drug clearance. Preliminary data suggest that proactive TDM may also have a role in de-escalating anti-TNF therapy in patients in clinical remission including stopping the immunomodulator when combined with anti-TNF therapy. However, several knowledge gaps and limitations hinder the wide implementation of TDM in clinical practice, including the optimal drug concentration to target the lag time between sampling and results and the lack of harmonization of TDM assays. Recent advances regarding the role of TDM include the use of rapid point-of-care assays and the incorporation of model-informed precision dosing. The aim of this Special Issue is to highlight the clinical utility of TDM and discuss the barriers and recent advances of TDM of biologics in IBD and other IMID.
    Keywords: ulcerative colitis ; Crohn&rsquo ; s disease ; inflammatory bowel disease ; infliximab ; adalimumab ; certolizumab pegol ; golimumab ; vedolizumab ; ustekinumab ; therapeutic drug monitoring ; immunogenicity ; rheumatoid arthritis ; ankylosing spondylitis ; psoriasis ; clearance ; model informed precision dosing ; bic Book Industry Communication::M Medicine
    Language: English
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Inflammatory bowel disease (IBD) encompasses chronic idiopathic relapsing and remitting gastrointestinal autoimmune diseases characterized by chronic inflammatory disorders of complex etiology, posing clinical challenges due to their often therapy-refractory nature. The primary disorders within the IBD classification are ulcerative colitis (UC) and Crohn’s disease (CD), sharing similarities but exhibiting distinct differences, sometimes making their discrimination challenging.A prominent feature of IBD is the inflammation of the intestinal mucosa, characterized by the robust and persistent infiltration of immune cells and compromised intestinal barrier integrity, leading to a phenomenon known as “leaky gut.” Inflammation can manifest acutely or chronically, known as relapsing, and can increase in severity over time, thereby causing life-long morbidities and reduced quality of life for affected individuals, underscoring the need for a deeper comprehension of the molecular contributors to disease pathogenesis and progression.
    Keywords: inflammatory bowel diseases ; cell autofluorescence ; immune cells ; NADH ; FAD ; flow cytometry ; multiphoton microscopy ; colitis ; colitis-associated cancer ; inflammatory bowel disease ; colorectal cancer ; colon adenocarcinoma ; ulcerative colitis ; Crohn’s disease ; cDNA microarray ; transciptomics analysis ; microarray ; inflammatory bowel diseases (IBDs) ; vasculature ; angiogenesis ; gut vascular barrier ; vessel permeability ; epithelial barrier ; homeostasis ; acetylcholine ; muscarinic receptor ; non-neuronal acetylcholine ; mucosal wound healing ; ferroptosis ; leaky gut ; inflammatory bowel disease (IBD) ; triple-culture ; Caco-2 ; HT29-MTX-E12 ; THP-1 ; monocyte-derived macrophage ; inflammation ; TEER ; FITC-dextran 4 kDa (FD4) ; pro-inflammatory cytokines ; HIF-1α ; PHD2 ; AKT ; intestinal epithelial cells ; probiotics ; LPS ; antigen-specific T-cells ; celiac disease ; gliadin ; IBD ; food antigens ; intestinal Behcet’s disease ; immune mechanism ; biological agents ; claudin ; tight junctions ; barrier function ; gut ; ZO-1 ; actin ; cell migration ; cell division ; colon cancer ; PMNs ; LDs ; FOXO3 ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Recent years have seen growing interest in equine lung and heart health, and advances in technology and a focus on equine welfare have driven this research. This Special Issue explores novel diagnostic and therapeutic approaches, including imaging techniques and lung function testing, immunological features, and immunomodulatory treatments for equine asthma and common racehorse respiratory issues. Moreover, it reports on novel echocardiography data of donkeys. This collection offers valuable insights into equine cardio-respiratory medicine.
    Keywords: equine asthma ; exercise-induced pulmonary hemorrhage ; racehorse respiratory medicine ; donkey cardiology ; bic Book Industry Communication::M Medicine
    Language: English
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue focuses on treating the associated comorbidities and complications of cerebral palsy. Increased prescription of technology means that we are treating some comorbidities of cerebral palsy earlier or even pre-emptively. Increased life expectancy, compared with 20 years ago, means that we are also seeing even later complications of cerebral palsy. However, increased access to intensive medical care at home, non-invasive ventilation, and total parenteral nutrition now exist. There is also greater engagement with the perspectives and expectations of parents/carers and children. As society begins to discuss mental health more openly, we are also starting to recognise the significant two-way associations between disability and mental health. Ethical consultation may be warranted when harm with treatment exceeds the benefit. As we prepare children with cerebral palsy for adulthood, there is more thought and discussion around issues such as pain, mental health, quality of life, independence, and participation. Researchers in the field of cerebral palsy have contributed original articles and reviews which help build our evidence base to guide shared decision making.
    Keywords: mental health ; anxiety ; depression ; cerebral palsy ; adolescence ; young adults ; young people ; adolescents ; unmet need ; health services ; physical therapy ; occupational therapy ; fracture ; bone fragility ; mortality ; epidemiology ; age-adjusted mortality rates ; death certificate ; medical education ; severe neurological impairment ; scoliosis ; shared decision-making ; respiratory ; hospitalisations ; antibiotics ; Indigenous ; inequities ; cell therapies ; stem cells ; comorbidities ; outcome measures ; clinical studies ; inflammation ; biomarker ; comorbidity ; scoping review ; co-design ; intervention ; participation ; involvement matrix ; public and patient involvement ; early intervention ; infant vocalisations ; infants ; single-subject research design ; CP ; infant ; stress ; parents ; fathers ; parent–infant interaction ; representations ; epilepsy ; children ; neuroimaging ; seizure outcome ; Sialorrhea ; submandibular duct relocation ; postoperative management ; ultrasound ; piecewise model ; muscle volume ; cross-sectional area ; GMFCS ; upper limb ; sensory function ; bimanual intensive functional therapy ; hand function ; associated impairment ; register ; low- and middle-income country ; hip displacement ; hip surveillance ; adductor-psoas release ; hip reconstruction ; guided growth ; salvage surgery ; disability ; emotion regulation ; atropine ; sialorrhea ; pediatric ; drooling ; sublingual ; developmental disorders ; neurodevelopmental disorders ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint entails descriptions of novel issues and challenges for primary mental healthcare regarding both general and vulnerable populations on a global scale. It is intended for health professionals and all who are interested in mental health care at the primary level.
    Keywords: depression ; sense of coherence ; burnout ; COVID-19 ; nurses ; medication adherence ; mental health nurses ; tacit knowledge ; schizophrenia ; sensory processing sensitivity ; environmental sensitivity ; university students ; nursing ; scale ; somatization ; number of diseases ; coping strategies ; sex ; aggression ; alexithymia ; comprehensibility ; quality of life ; family caregivers ; students ; medical ; psychological problem ; undergraduate ; Saudi Arabia ; n/a ; prospect theory ; applied psychology ; health ; decision making ; behavior ; prevention ; multiple sclerosis ; Beck depression inventory ; anxiety ; fatigue ; mediation ; lawyers ; suicidal ideation ; occupational stress ; loneliness ; perceived stress ; mental health ; work overcommitment ; mental health care ; adolescence ; internalizing/externalizing problems ; social skills ; neurodevelopmental disorders ; filmmaking intervention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint includes studies on diagnosing, evaluating and managing the pathologies diagnosed during pregnancy. The information provided in these pages is helpful for specialists in obstetrics and gynaecology but also for other medical specialities involved in treating pregnant women with associated pathologies. Studying the articles in the reprint could contribute to improving case management.
    Keywords: pregnancy ; fetus prenatal care ; high-risk ; pathology ; bic Book Industry Communication::M Medicine
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The aim of this Special Issue is to specify relevant principles of mathematics and mechanics in order to explore and understand biological problems. We summarize the most important parameters that influence human performance and that are related to the health sciences for all age groups, throughout their lives. We present papers that aim to introduce the latest research in the fields of health, quality-of-life improvement, and sport rehabilitation and that summarize their recommendations for best practice. The aim for this Special Issue is, therefore, to effectively combine and coordinate research and results in order to understand and improve human movement in medicine, sports, and at work.
    Keywords: tendinopathy ; Achilles tendon ; hyaluronic acid ; viscoelastic properties ; isometric contraction ; matrix metalloproteinase 3 ; interleukin-1beta ; fascia ; chronic low back pain ; myofascial release ; quality of life ; older adults ; oldest-old ; measurement invariance ; SHARE European Survey ; therapeutic exercises ; chronic neck pain ; scapular dyskinesia ; DOMS ; vibration ; post-exercise muscle damage ; physical exercise ; recovery ; women’s rugby ; anthropometry ; body composition ; adiposity ; somatotype ; lower-body strength ; accelerometry ; falls ; squat jump ; syndesmosis ; anterior inferior tibiofibular ligament ; high ankle sprain ; rotational instability ; posterior malleolus ; stabilization ; anatomic repair ; syndesmotic screw ; suture-button ; internal bracing ; treatment algorithm ; cardiac rehabilitation ; peripheral artery disease ; COVID-19 ; intermittent claudication ; review ; pressotherapy ; compression ; regeneration ; return-to-play ; rotator cuff repair ; shoulder injuries ; shoulder surgery ; shoulder assessment ; chronic obstructive pulmonary disease ; COPD ; acupuncture ; acupuncture therapy ; acupuncture treatment ; health-related quality of life ; anterior knee laxity ; stiffness ; general joint laxity ; genu recurvatum ; low back pain ; physical activity ; trunk alignment ; rasterstereographic system ; young males ; tissue flossing ; floss band ; vascular occlusion ; muscle strength ; muscle endurance ; warm-up ; TECAR therapy ; high-intensity laser therapy ; manual therapy ; muscle disorders ; hemophilia ; knee ; virtual reality exposure therapy ; joint pain ; physiotherapy ; daily physical function ; middle-aged and older adults ; CHARLS ; aging ; appendicular muscle mass ; inflammaging ; biomarkers ; adiponectin ; sarcopenia ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The 3D analysis of human movement aims to objectively and quantitatively assess motor functions and alterations. It is a valuable method for sport scientists, coaches, and clinicians to evaluate sport performance, common movements, and alterations. The feasibility of 3D analysis is increasing because it can be adopted both in a laboratory setting or directly in the field, in static or dynamic conditions, and for physiological or pathological movements. This evaluation technique can be adopted for many people, including children, adolescents, adults, and older people, whether they are sedentary or athletes and whether they are healthy or motor-impaired people.
    Keywords: virtual reality ; augmented reality ; lifelogging ; mirror world ; health ; posture training ; feedback ; COVID-19 ; neck-shoulder-region ; shoulder protraction ; upper crossed syndrome ; posture weakness ; physical inactivity ; sedentary behavior ; soccer ; climbing ; exhaustion ; fatigue ; training ; machine learning ; sports ; gender ; data mining ; artificial intelligence ; posture ; reproducibility ; mobile app ; movement ; kinesiology ; sport performance ; inertial sensor ; inertial sensor device ; inertial measurement unit ; training load ; external load ; physical demand ; handstand ; postural control ; postural balance ; sEMG ; stabilometric assessment ; exercise ; Nordic walking ; walking ; 3D kinematics ; biomechanics ; gait analysis ; kyphosis ; spinal mouse ; photogrammetry ; postural evaluation ; bicycle ; cyclists ; saddle pressure ; perineal pressure ; urogenital system ; injury prevention ; cervical ROM ; elastic taping ; neck pain ; musculoskeletal health ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In the orthopedic surgical field, knee surgeries, including articular cartilage repair procedures, meniscus surgery, ligament reconstruction surgery, osteotomy surgery, and partial/total knee arthroplasty surgery, have made great advances over the last few decades. This Special Issue highlights and focuses on the surgical concepts and techniques, decision-making processes, perioperative management protocols, and clinical outcomes of the recent various advanced knee surgery procedures.
    Keywords: high tibial osteotomy ; TomoFix ; plate position ; anatomical conformity ; dual-energy CT ; Hounsfield unit ; bone mineral density ; volumetric phantomless BMD ; opportunistic CT ; orthopedic surgeon ; planning ; survey ; total knee arthroplasty ; unicompartmental knee arthroplasty ; anterior cruciate ligament ; reconstruction ; bone tunnel widening ; adjustable-loop device ; interference screw ; hamstring tendon ; autograft ; tibial component alignment ; radiographic references ; extramedullary system ; tranexamic acid ; clamping time ; transfusion ; estimated blood loss ; continuous cold flow therapy ; cryotherapy ; pain ; opioids consumption ; patient satisfaction ; bone marrow lesion ; knee ; meniscus ; root tear ; root repair ; femorotibial joint ; chondromalacia ; aging ; body mass index ; magnetic resonance imaging ; automated detection ; detection algorithm ; deep learning ; venous thromboembolism ; medial collateral ligament ; strain ; video extensometer ; medial opening-wedge high tibial osteotomy ; central sensitization ; patient-reported outcomes ; osteotomy site pain ; minimal clinically important difference ; human umbilical cord blood derived mesenchymal stem cells ; cartilage regeneration ; cartilage repair ; osteoarthritis treatment ; stem cell therapy ; Outerbridge ; degeneration ; spacer block ; intramedullary rod ; femorotibial congruence ; unicompartmental arthroplasty ; osteoarthritis ; cartilage ; stem cells ; umbilical cord blood ; femur fracture ; polyethylene insert ; osteoporosis ; multivariate logistic analysis ; atelocollagen ; microfracture ; ACIC ; bone marrow aspirate concentrate ; human umbilical cord blood-derived mesenchymal stem cells ; knee osteoarthritis ; loosening ; arthroplasty ; machine learning ; transfer learning ; review ; prosthesis ; meniscus root ; medial meniscus posterior root ; medial meniscus posterior root tear ; meniscus root repair ; transtibial pull-out repair ; bone tunnel enlargement ; anterior cruciate ligament reconstruction ; landmark ; lateral tibial spine ; anatomy ; bic Book Industry Communication::M Medicine
    Language: English
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Over the years, digestive endoscopy has gone through a revolution. With different technological improvements, its diagnostic role is indeed becoming more and more sophisticated and is even moving closer to pathological evaluation. Above all, its therapeutic purpose is to date the first line of treatment for several gastrointestinal diseases. Importantly, the role of digestive endoscopy is also crossing over the mere concept of the GI tract and digestive diseases and will probably find a place in a more holistic concept of health. In this Special Issue, several emerging techniques are addressed, highlighting how endoscopy is emerging as a minimally invasive treatment procedure for several gastrointestinal diseases and post-surgical complications. However, crucial to this is the safety of all endoscopic processes, starting from endoscopic suites to the management of intra- and post-procedural complications.
    Keywords: interventional endoscopy, ERCP, cholangioscopy, biliopancreatic endoscopy, CH-EUS, radiofrequency ablation, necrosectomy, locoregional treatment, bariatric endoscopy, artificial intelligence ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Modern medical imaging systems provide information about the patient's health condition. Their precision, resolution and sensitivity are increasing, and new possibilities of differentiating the condition of tissue are constantly appearing. These advances are also taking place in musculoskeletal imaging. Increasingly accurate imaging in various modalities allows us to discover new relationships between the image and the diagnosis. It is therefore important to use all this information to best serve the patient. That is why research related to the analysis of medical images is so important, because it allows us to indicate what is invisible to the naked eye or to quantify what has so far been measured by humans or subject to discretionary assessment. This collection includes 25 works related to the analysis of images created during diagnostics of the musculoskeletal system using various modalities—from X-ray and fluoroscopy to conventional or spectral computed tomography, magnetic resonance imaging, ultrasound, elastography, PET/CT and systems for analyzing patient mechanics. Research was carried out related to the detection of various conditions, parameterization of clinical and population phenomena, and detection of image–clinical condition relationships. Despite the current popularity of machine learning techniques, the collection is dominated by classic engineering methods related to image processing. Several works use textural analysis, which has not been appreciated so far, which is particularly related to the imaging of the structure, especially of bones.
    Keywords: bone imaging, musculoskeletal imaging, image processing, image analysis, segmentation, textural analysis, machine learning ; bic Book Industry Communication::M Medicine
    Language: English
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Pain biomarkers are biological indicators or measurable characteristics that can provide information about the presence, severity, or underlying mechanisms of pain. They are valuable for several reasons: Diagnosis and differential diagnosis: Biomarkers can help in the diagnosis of various pain conditions and differentiate between different types of pain, such as neuropathic, inflammatory, or nociceptive pain. This can lead to more accurate and timely diagnoses, which in turn can improve patient care. Monitoring treatment efficacy: Pain biomarkers can be used to track how well treatments are working for individuals suffering from chronic pain conditions. This allows healthcare providers to make informed decisions about adjusting treatment plans, optimizing pain management, and avoiding unnecessary or ineffective interventions. Drug development and testing: Biomarkers play a crucial role in the development of new pain medications and therapies. They can help researchers identify potential drug targets, screen compounds for their pain-relieving properties, and assess the safety and efficacy of experimental treatments in clinical trials. Personalized medicine: Pain biomarkers may, in a future, contribute to treatments, tailored to an individual's unique genetic and biological disposition. Reducing opioid misuse: By using biomarkers to assess pain and treatment responses, healthcare providers can make more informed decisions about opioid prescriptions, potentially reducing the overuse and abuse of these medications.
    Keywords: analgesia ; biomarker ; CSF ; cytokine ; inflammation ; neuropathy ; neurotransmitter ; pain ; QoL ; sensitization ; sensory ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue focuses on the comprehensive understanding and novel treatments in the realm of cornea and ocular surface diseases. Ranging from the relatively benign manifestations of keratoconjunctivitis sicca to more critical conditions such as corneal ulcers, ocular surface diseases pose a considerable challenge in clinical ophthalmology. Such conditions can severely compromise the transparency of the cornea, often necessitating interventions such as keratoplasty. A significant emphasis of this edition is on the paramount importance of pre-surgical optimization. A successful keratoplasty is often predicated on the health of the ocular surface. Through a series of insightful articles, the importance of enhancing tear function, rehabilitating the normal lid anatomy, and ensuring a robust limbal stem cell supply is elucidated. Properly addressing these factors has a direct bearing on the success rate of the subsequent surgical intervention. Another highlight of this Special Issue is the presentation of cutting-edge treatments. Researchers from around the globe share their findings, detailing advancements in both surgical and non-surgical treatments. These range from innovative surgical techniques and tools to groundbreaking pharmaceutical agents that hold promise in managing and possibly reversing some of these conditions. In summary, this Special Issue serves as a repository of the latest knowledge in the management of cornea and ocular surface diseases, aimed at both the seasoned ophthalmologist and budding researchers in the field.
    Keywords: cornea ; ocular surface disease ; dry eye ; corneal ulcer ; keratoplasty ; bic Book Industry Communication::M Medicine
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  • 18
    Publication Date: 2024-01-08
    Description: This reprint, entitled “Management of Acute and Chronic Complications of Lysosomal Storage Diseases in Children and Adults: Current Practice and Future Opportunities”, covers broad aspects of this group of rare diseases. The first theme includes articles on the management of pain, corneal clouding, gastrointestinal and airway diseases in Mucopolysaccharidoses and Mucolipidoses, and the evaluation of dysphonia in Pompe disease. Additionally, attention deficit and ADHD and the management of atherosclerosis in Fabry disease are considered here. The second theme includes diagnostic conundrums in lysosomal storage diseases, e.g., the prenatal diagnosis of Gaucher disease during pregnancy, the diagnosis of secondary hyperparathyroidism in Mucolipidoses, and the application of the new biomarker “plasma neurofilament light” in Niemann Pick C disease, as well as the correlation of enzyme activity with molecular diagnosis in Pompe disease. The articles in the third theme describe the impact of therapies on clinical outcomes. For example, a systematic review of the impact of enzyme replacement therapy on late-onset Pompe disease and trehalose use on Niemann Pick A and B is included. The remaining articles describe the NHS processes for overcoming challenges resulting from the COVID-19 pandemic and the differences in the transition from paediatric to adult services between different countries.
    Keywords: Mucopolysaccharidosis ; corneal clouding ; penetrating keratoplasty ; deep anterior lamellar keratoplasty ; mucopolysaccharidoses ; airway ; obstruction ; management ; Fabry disease ; attention ; Attention Deficit/Hyperactivity ; cognition ; late-onset Pompe disease ; gastrointestinal ; smooth muscles ; PROMIS–GI symptom scales ; GAAKO mice ; glycogen storage disorder ; translational research ; patient-reported outcomes measures ; mucopolysaccharidosis ; MPS ; disease manifestations ; symptoms ; morbidity ; spine disease ; anaesthesia ; perioperative complications ; surgery ; pompe disease ; speech ; voice ; dysphonia ; acoustic ; auditory-perceptual ; GRBAS ; respiratory ; Pompe disease ; gene panel sequencing ; alpha-glucosidase ; GAA ; dried-blood spots ; fabry disease ; neuropathic pain ; depression ; Fabry ; atherosclerosis ; ischaemia ; perfusion ; angina ; Sanfilippo syndrome ; mortality ; Niemann–Pick C ; neurofilament light ; biomarkers ; neurological disease ; glycogen storage disease type II ; enzyme replacement therapy ; COVID-19 ; inherited metabolic disorders ; rare autoinflammatory diseases ; health care providers ; Gaucher disease ; NIHF ; perinatal-lethal Gaucher disease ; PLGD ; ichthyosis ; GBA gene ; airway management ; radiology ; hyoid bone ; chin ; intubation ; intratracheal ; lysosomal storage disease (LSD) ; Niemann–Pick type A ; Niemann–Pick type B ; acid sphingomyelinase ; sphingolipid deposition ; trehalose ; mucolipidosis type II ; ML II ; I-cell disease ; hyperparathyroidism ; mucolipidosis ; ML ; MLII ; transition service ; adult metabolic medicine ; collaboration ; challenges ; inherited metabolic diseases ; healthcare systems ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Molecular toxicology is a field that investigates the interactions between chemical or biological molecules and organisms at the molecular level. In this Special Issue, we focus on the toxic effects and mechanisms of action of chemical and biological molecules, will be of great interest of readers in molecular toxicology and applied pharmacology.
    Keywords: smoking ; inflammatory ; cytokine ; human serum ; GO ; PRRSV ; FT-SPR ; sensitization ; NNK ; nicotine ; cytotoxicity ; genotoxicity ; cytochrome P450 2A13 ; Aspergillus flavus ; aflatoxins B1 ; carcinogen ; Surface-Enhanced Raman Scattering ; colloidal Au nanoparticles ; portable Raman spectrometer ; Euphorbia semen ; Euphorbia factors ; transcriptome ; RNA sequencing ; bioinformatics ; gene structure ; neuroblast differentiation-associated protein AHNAK ; hepatocellular carcinoma (HCC) ; insulin-like growth factor 1 receptor (IGF-1R) ; interactome ; field cancerization ; 8–17 DNAzyme ; gene silencing ; catalysis ; antisense ; chemical modifications ; 6-cyclohexyl methyl-β-D-maltoside ; transduction efficiency ; conditionally replicative adenovirus ; lethal effect ; gene therapy ; PBDE ; immunotoxicity ; macrophage ; reactive oxygen species ; apoptosis ; immune function ; breast cancer ; signature ; aging ; cancer ; nomogram ; immunotherapy ; tumor mutation burden ; doxorubicin ; Toll-like receptor 4 ; cardiotoxicity ; heart ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
    Language: English
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  • 20
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, we have gathered high-level research papers from all over the world. We would like to thank all researchers for their commitment to the field. From diagnostic ultrasound of different fetal conditions to advanced cardiovascular imaging leading to fetal MRI and from serum markers and biomarkers in maternal and fetal conditions to new modalities in fetal therapy, this Special Issue covers a large scale view of the present spectrum of modern perinatal medicine. Again, a warm thank you to all contributors.
    Keywords: fetal echocardiography ; fetal abnormalities ; fetal therapy ; genetic testing, prenatal medicine ; bic Book Industry Communication::M Medicine
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The topics covered in this Special Issue range from breastfeeding and early-life nutrition to effects on microbiota, infection, allergy, asthma, and the mechanisms of immunomodulation via (the early introduction of) nutrition on infections and the development of (food) allergies.
    Keywords: diet ; pregnancy ; cord blood ; fatty acids ; n-3 PUFAs ; n-6 PUFAs ; arachidonic acid ; phospholipids ; atopic eczema ; NICE birth cohort ; multi-allergen ; early introduction ; food allergy ; safety ; efficacy ; prevention ; allergic sensitization ; foetal immune ontogeny ; gene/environment interactions ; asthma ; eczema ; maternal diet ; PUFAs ; vitamin D ; Mediterranean diet ; microbiome ; breastfeeding ; functional gastrointestinal disorder ; partial hydrolysate ; peptide ; protein ; infancy ; childhood ; immune development ; probiotic ; microbiota ; allergy ; atopic dermatitis ; breastmilk ; house dust mite ; Der p 1 ; Asthma ; total IgE ; atopy ; sensitization ; oral tolerance ; early food introduction ; milk protein ; cow’s milk allergy (CMA) ; maternal atopy ; epigenetics ; pediatric asthma ; cohort study ; immune complex ; trained immunity ; RSV ; bovine IgG ; preF protein ; cow’s milk allergy ; allergen ; hypoallergenic infant formula ; n/a ; IgA deficiency ; selenium deficiency ; zinc deficiency ; recommended dietary allowances ; immune system ; allergen molecules ; milk allergen micro-array ; peptides ; anaphylaxis ; milk tolerance ; diagnosis ; IgE sensitization ; children ; bic Book Industry Communication::M Medicine
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Helicobacter pylori is one of the most common infections in the world, affecting roughly half of all humans. Although it is not an infection that causes death immediately after infection, it is one of the largest emerging infectious diseases in the history of humankind, causing a wide variety of diseases and, in the long term, serious complications such as stomach cancer. This Reprint contains empirical studies and reviews regarding the diagnosis, treatment, complications, and management of H. pylori infection, including new diagnostic methods, effective eradication regimens, the management of gastric cancer, and other topics.
    Keywords: gastric cancer ; biliopancreatic reflux ; gastritis ; carcinoma ; endoscopic surveillance ; Helicobacter pylori infection ; gastric stump cancer ; Helicobacter pylori ; H. pylori ; rifabutin ; treatment ; eradication failure ; culture ; bismuth ; rescue ; Hp-EuReg ; third-generation ultrathin endoscope ; transnasal endoscopy ; narrow-band imaging ; Kyoto classification of gastritis ; gastric atrophy and intestinal metaplasia ; diagnosis ; stool antigen test ; urea breath test ; peptic ulcer disease ; triple therapy ; vonoprazan ; dyspepsia ; Kyoto Classification of Gastritis ; cagA ; Okinawa ; endoscopic findings ; Helicobacter infection ; tetracycline ; eradication ; penicillin allergy ; furazolidone ; metronidazole ; amoxicillin ; child ; host genetic factor ; iron deficiency anemia ; iron demand ; iron uptake ; sports activity ; virulence factor ; gastric lymphoma ; MALT lymphoma ; radiotherapy ; chemotherapy ; rituximab ; dual therapy ; vonoprazan (VPZ) ; amoxicillin (AMOX) ; clarithromycin (CAM) ; bic Book Industry Communication::M Medicine
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  • 23
    Publication Date: 2024-02-27
    Description: Collective monograph contains the results of scientific research devoted to new views and proposals for the diagnosis of certain diseases. The proposed solutions are important for clinical practice and inspire optimism in obtaining encouraging results in overcoming some pathologies. Chapter 1 is dedicated to endoscopic retrograde cholangiopancreatography - a contrast study of the bile ducts and ductal system of the pancreas, which is achieved by their cannulation with the help of a flexible endoscope and their visualization by X-ray (fluoroscopy). Thanks to this, it becomes possible to diagnose and perform medical interventions for choledocholithiasis, benign and malignant obstruction of the bile ducts, chronic pancreatitis accompanied by obstruction of the pancreatic ducts. Chapter 2 presents the results of the development of a thermoelectric device for diagnosing inflammatory processes and pain syndrome in degenerative-dystrophic diseases of the lumbosacral spine. Such a device makes it possible to save, process and visualize measurement results on the display of the device and on a personal computer in real time. The results of clinical studies of thermometric indicators in the lumbosacral region of the spine in persons with chronic pain syndrome against the background of degenerative-dystrophic pathology of the spine in the presence of hernias and protrusions of intervertebral discs are given. The effectiveness of the proposed thermoelectric device in medical practice has been confirmed. Chapter 3 presents the results of the examination of various contingents of the population: students, athletes, mobile operators, people with hearing loss, post-covid syndrome and psychophysiological lability developed under martial law. The features of information processing by examinees with different degrees of functional mobility of nervous processes are highlighted. It was found that the deprivation of auditory function, post-conviction syndrome, psychophysiological lability developed in the conditions of martial law significantly reduce the level of neural processes and the ability to process information. The evaluation scales of neurodynamic and sensorimotor functions proposed for use in the medical field can be used to optimize diagnosis and increase the effectiveness of monitoring neurological morbidity, including in people with special needs. Chapter 4 is devoted to the problems of children's neuropsychiatric diseases, in particular brain damage in children with ASD. Restrained optimism is expressed for the prospect of overcoming this severe psychiatric pathology in the foreseeable future due to the introduction of genetic, biochemical and immunodiagnostic approaches, as well as metabolic and immunotherapeutic interventions with neuroprotective effects. Arguments are presented in favor of the fact that the successful testing in clinical practice of evidence-based personalized multidisciplinary strategies of diagnosis and treatment will allow a breakthrough in the clinical management of children with severe mental disorders in the near future. This will provide not only the possibility of recovery from a prognostically unfavorable and currently incurable neuropsychiatric disorder, but will also contribute to stopping the large-scale threatening epidemic of neuropsychiatric syndromes in the modern child population. Chapter 5 presents the evolution of views on the problem of Internet addiction, provides information on its prevalence, comorbidity with mental disorders, and provides an overview of modern clinical classifications and psychometric tools for its diagnosis. A single definition of "cyber addiction" is singled out, based on the fact that the object of addiction is interaction with various information resources and technical means. The proposed clinical diagnostic criteria, which are based on the criteria for the diagnosis of mental and behavioral disorders due to the use of psychoactive substances ICD-11, and the characteristics of the boundary with normative behavior when using various information resources and technical means are provided. The development and validation of a new psychodiagnostic screening tool based on the proposed cyber addiction paradigm, the YSCAS scale, is presented. The monograph is intended for doctors and practitioners who are engaged in the search and implementation of effective diagnostic methods to overcome the problems associated with the detection and treatment of certain pathologies. The monograph can also be useful to postgraduate and master's students of universities in the relevant educational and scientific profile.
    Description: Published
    Keywords: Endoscopic retrograde cholangiopancreatography ; Endoscopic lithoextraction ; Osteochondrosis of the spine ; Thermoelectric device ; Individual-typological properties ; Functional mobility ; Sensorimotor reactivity ; Autism spectrum disorders ; Attention deficit hyperactivity disorder ; Obsessive-compulsive syndrome ; Immunodiagnostics ; Internet addiction ; Cyberaddiction ; YSCAS scale ; bic Book Industry Communication::M Medicine
    Language: English
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  • 24
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint focuses on the importance of the micronutrient iron in human physiological iron homeostasis and iron-related diseases. Daily adequate dietary iron supply ensures vital body functions and hemoglobin synthesis during erythropoiesis. During the last few decades, scientific evidence has shown that the maintenance of human iron homeostasis is an important factor for physical and mental health. The present reprint gives an overview of how iron, as an essential dietary element, is responsible for physiological and pathological biochemical processes in the human body. For the readership, this relevant information will provide an evidence-based update on the complex regulatory mechanisms and related diseases of iron metabolism.
    Keywords: iron metabolism ; iron homeostasis ; micronutrient iron ; physiology ; pathology ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 25
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue addresses recent advances in the research of plant-derived natural products, their mechanisms of action and how they can influence health and disease. Plant-derived natural products have been well known since antiquity due to their beneficial effects on human health, and since then, they have attracted the interest of the scientific community, leading to the identification, isolation and quantification of their compounds and research on their biomedical properties. They have been found to be rich in phytochemicals, such as terpenes and phenolic compounds, with proven antioxidant, anti-inflammatory, antimicrobial, antitumor and prebiotic properties, and therefore, they have been suggested as potential candidates for the therapeutic management of several chronic diseases. Some of them include inflammatory bowel disease, diabetes, non-alcoholic fatty liver disease, arthritis and cancer, in which inflammation, oxidative stress and dysbiosis mechanisms are implicated. Furthermore, given the increased economic burden, the side effects and the low compliance rates of patients who receive standard medical treatments, plant-derived natural products could possibly serve as adjunct therapeutic agents for chronic diseases.
    Keywords: plants ; natural products ; free radicals ; inflammation ; medicinal ; caffeic acid ; antibacterial ; antifungal ; antioxidant ; anticancer ; juglone ; Juglans regia ; mogrol ; mogroside ; phytochemical ; pharmacology ; osteoporosis ; antiobesity ; anti-inflammation ; neurodegenerative disorders ; anticancer agents ; aromadendrane ; bryophytes ; cytokinesis inhibitor ; Plagiochila species ; plagiochilins ; analgesic activity ; traditional medicine ; wound healing ; colon carcinogenesis ; 1,2 dimethylhydrazine ; hesperetin ; capecitabine ; Jatropha tanjorensis ; Fraxinus micrantha ; HPTLC ; anti-obesity activity ; high-fat diet model ; histological ; Alzheimer ; acetylcholinesterase inhibitors ; Euonymus laxiflorus Champ. ; bioactive compounds ; medicinal plants ; P. lentiscus ; GC/MS ; HPLC-DAD ; antioxidant activity ; antibacterial activity ; antifungal activity ; extract ; molecular docking ; Artemisia arborescens ; Artemisia inculta ; phenolic compounds ; terpenes ; trace metals ; antioxidant capacity ; Eurycoma longifolia Jack ; anti-inflammatory ; antinociceptive effect ; antipyretic effects ; gastroprotective activity ; gastric ulcer ; Thai traditional medicine ; phytochemicals ; inflammatory bowel disease ; gut microbiota ; Mastiha ; Curcumin ; Boswellia serrata ; Artemisia absinthium ; lipidomic profile ; Tulsi ; Ocimum sanctum ; ischemic stroke ; photothrombotic ischemia ; medicinal plant ; n/a ; bic Book Industry Communication::M Medicine
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  • 26
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Translational research is required to uncover the underlying pathomechanisms of neurological and psychiatric disorders, search for new biomarkers, and develop novel therapeutics. Complex polygenic, multifactorial, and heterogeneous mechanisms have been elucidated using in vivo and in vitro models. Advanced preclinical models have recently revealed an intriguing interaction between sex/gender and aging in the pathogenesis and clinical manifestations of neuropsychiatric disorders. Despite these advances, much work remains to be carried out to fully understand the underlying pathology of these conditions and to develop treatments that can significantly improve the lives of those who suffer from them. The current challenge in the field of neurological and psychiatric disorders is the development of disease-modifying, effective treatments for these complex and long-term debilitating conditions with a high malady burden. The first edition of this research topic, entitled 'Emerging Translational Research in Neurological and Psychiatric Diseases: From In Vitro to In Vivo Models,' emphasizes the importance of translational research in bridging the gap between basic research and clinical applications. Furthermore, it provided a venue for researchers to share their findings and progress in translational research in this field.
    Keywords: Alzheimer&rsquo ; s disease ; Parkinson&rsquo ; multiple sclerosis ; stroke ; migraine ; pain ; depressive disorder ; anxiety disorder ; autism spectrum disorder ; sleep wake disorders ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 27
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: undefined
    Keywords: Medicine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 28
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Various classes of natural and synthetic molecules that can be classified as biomaterials find application in all fields of dentistry. Biomaterials should be biocompatible to minimise toxicity and bioactivity to ensure or simulate biological effects. They are used, for instance, to enhance antibacterial activity and improve the healing process. Calcium silicates, for illustration, are biomaterials used in endodontics that have proven their excellent biological, physico-chemical, and mechanical properties. However, some of these are considered too soluble, and this is almost completely due to their hardness when used as endodontic sealers, making endodontic retreatment very difficult. Despite manufacturers' best efforts, it is sometimes difficult to marry bioactivity, biocompatibility, and clinical benefits in a biomaterial; therefore, in this content, the work of researchers is invaluable.
    Keywords: calcium silicate cement ; retrograde materials ; premixed cement ; powder–liquid cement ; chemical composition ; EDX ; caries prevention ; anterior restorations ; ceramic ; dental veneers ; follow-up ; non-vital teeth ; porcelain laminate veneers ; vital teeth ; antimicrobial ; osseointegration ; surface modification ; tissue engineering ; root canal retreatment ; calcium silicate-based cement ; ProTaper Universal Retreatment ; D-Race ; dentin hypersensitivity ; desensitizing agents ; calcium phosphate ; hydroxyapatite ; nano-hydroxyapatite ; peri-implantitis ; periodontitis ; periapical radiograph ; deep learning ; neural networks ; image enhancement ; carious lesion activity ; irreversible pulpitis ; partial pulpotomy ; vital pulp therapy ; mineral trioxide aggregate ; furcation involvement ; image segmentation ; Gaussian high-pass filtering ; image preprocessing ; CNN ; calcium silicate material ; confocal laser scanning microscope ; deciduous tooth ; digital microscopy ; flowability ; micro-CT ; pulpectomy primary teeth ; root canal filling ; SEM ; zinc oxide eugenol ; bic Book Industry Communication::M Medicine
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  • 29
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The healthcare system’s ability to diagnose and care for people with schizophrenia has improved in recent decades, as effective pharmacological and psychosocial interventions are now available. However, schizophrenia remains a leading cause of disability and premature mortality. The utilization of pharmacological and psychosocial interventions in the healthcare system, which have the potential to significantly improve the quality of life for people with schizophrenia, heavily depends on medical professionals completing accurate and comprehensive assessments of patients’ psychopathologies, cognitive profiles, physical health statuses and any environmental factors that may influence them. This Special Issue reprint on schizophrenia, from the Journal of Clinical Medicine, presents a collection of articles on current approaches to assessment and treatment, as well as new findings and future perspectives of schizophrenia research and care.
    Keywords: schizophrenia ; ERP ; mismatch negativity ; MMN ; P3a ; illness duration ; real-life functioning ; motivation circuits ; negative symptoms ; RDoC ; positive valence system ; salience system ; deficit syndrome ; diagnosis ; cognitive function ; social skills training ; physical comorbidities ; childhood abuse ; internalized stigma ; neutrophil-to-lymphocyte ratio ; antipsychotics ; hypothyroidism ; inflammatory markers ; expressive deficits ; experiential deficits ; functioning ; quality of life ; first psychotic episode ; first episode ; emotional processing ; social cognition ; MCCB ; MSCEIT ; real-world studies ; real-world effectiveness ; tolerability ; treatment adherence ; second-generation antipsychotics ; long-acting injectable antipsychotics ; delusional disorders ; psychosis ; sex ; women ; psychopathology ; construct ; schizophrenia spectrum ; renaming ; rethinking ; revising ; effort expenditure ; recent-onset schizophrenia ; persistent negative symptoms ; motivation ; neuropeptide S ; cognitive functioning ; rehabilitation ; AEP ; QEEG ; switch ; extrapyramidal symptoms ; treatment ; cognitive deficits ; self-evaluation of negative symptoms ; health-related quality of life ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 30
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    Publication Date: 2024-02-23
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 31
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    Dessau-Roßlau : Umweltbundesamt
    Publication Date: 2024-02-23
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 32
    Publication Date: 2024-02-09
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 33
    Publication Date: 2024-02-09
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 34
    Publication Date: 2024-05-08
    Description: The study analyses strategies and offers recommendations for leveraging the Global Stocktake's (GST) outcomes for national climate action, especially for Nationally Determined Contributions (NDCs). It emphasizes the need for coordinated efforts to ensure the results of the GST influence national political discourse. It proposes communication strategies tailored to the different stages of the NDC policy process and diverse target audiences. Drawing on a wide range of examples, the paper advocates for a nuanced and strategic approach to communication and emphasizes the importance of legitimacy and complexity in engaging stakeholders at different levels of decision-making.
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 35
    Publication Date: 2023-12-20
    Description: Striving to mitigate climate change, the European Union has adopted net-zero greenhouse gas emissions as a target for 2050. In this paper, European chemical industry roadmaps from the past six years are assessed and compared to uncover how the industry envisions its role in the transition to net-zero emissions. The roadmaps are assessed in terms of ambition level, technology and feedstock strategies, investment needs and costs, agency and dependency on other actors, as well as timeline and concretion. Although net-zero pathways are often drawn out in the roadmaps, some also choose to emphasize and argue for less ambitious pathways with emission reductions of only 40-60 %. The roadmaps vary widely in terms of the importance they assign to mechanical and chemical recycling, switching to biogenic carbon and carbon dioxide as feedstock, electrification and hydrogen, and carbon capture and storage. A commonality though, is that low-tech or near-term mitigation pathways such as demand reduction, reuse or material efficiency are seldom included. High investment needs are generally highlighted, as well as the need for policy to create enabling conditions, whereas the agency and responsibility of the chemical industry itself is downplayed. Our analysis highlights that the chemical industry does not yet have a strong and shared vision for pathways to net-zero emissions. We conclude that such a future vision would benefit from taking a whole value chain approach including demand-side options and consideration of scope 3 emissions.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
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  • 36
    Publication Date: 2024-03-07
    Description: Demand-side mitigation strategies have been gaining momentum in climate change mitigation research. Still, the impact of different approaches in passenger transport, one of the largest energy demand sectors, remains unclear. We couple a transport simulation model to an energy system optimisation model, both highly disintegrated in order to compare those impacts. Our scenarios are created for the case of Germany in an interdisciplinary, qualitative-quantitative research design, going beyond techno-economic assumptions, and cover Avoid, Shift, and Improve strategies, as well as their combination. The results show that sufficiency - Avoid and Shift strategies - have the same impact as the improvement of propulsion technologies (i.e. efficiency), which is reduction of generation capacities by one quarter. This lowers energy system transformation cost accordingly, but requires different kinds of investments: Sufficiency measures require public investment for high-quality public services, while efficiency measures require individuals to purchase more expensive vehicles at their own cost. These results raise socio-political questions of system design and well-being. However, all strategies are required to unleash the full potential of climate change mitigation.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 37
    Publication Date: 2024-04-04
    Description: Die schnelle und umfassende Emissionsminderung in der Energie- und Kreislaufwirtschaft ist der Schlüssel für die Begrenzung der Erderwärmung auf unter 2 °C. In Deutschland werden entsprechende Politiken seit den 1990er-Jahren verfolgt, allerdings erst in jüngster Vergangenheit mit dem notwendigen Nachdruck und der notwendigen Orientierung hin zu mehr Marktmechanismen. Wesentliche Handlungsfelder sind Energieeinsparung und erhöhte Energieeffizienz, Umstieg auf erneuerbare Energien, Bepreisung von Klimagasen sowie eine Reduzierung und Schließung der Stoffkreisläufe. In allen Handlungsfeldern sind Grundlagen geschaffen, es bleibt jedoch der Großteil des Weges noch zu gehen, um Klimaneutralität zu erreichen. Für einen schnellen Fortschritt spielen neben der Überwindung der technischen, ökonomischen und organisatorischen Herausforderungen auch Verteilungsfragen und die Einbettung in internationale Maßnahmen eine zunehmende Rolle.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 38
    Publication Date: 2024-04-11
    Description: The co-operation between municipalities and civil society actors and their independent impulses for urban development are discussed under the terms of co-production and city-making. This article summarises these activities as co-productive city-making (koSM). Forms of as well as advantages and disadvantages of koSM have been discussed in research and practice so far, but analyses of the longitudinal genesis of these activities and their significance for the development of a specific area are rare. This article uses the longitudinally collected, mixed-method data of a constellation analysis of the development of the Mirke neighbourhood in Wuppertal/Germany. Based on four points in time, the dynamics as well as the spatial development of the koSM can be presented - individually and in comparison to other developments. It can be seen that the koSM in the Mirke has grown at an above-average and dynamic rate and can accordingly be interpreted as a motor of neighbourhood development. Main actors and locations are identified. The study is the basis for a follow-up work analysing the reasons and structural effects of the koSM. The koSM is discussed both in its interrelations with municipal action and in its significance for integrated and sustainable urban development. The method of constellation analysis is critically discussed with regard to the relationship between effort and benefit.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 39
    Publication Date: 2024-04-22
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 40
    Publication Date: 2024-04-22
    Description: Real-world labs are witnessing continued growth and institutionalization in the field of transformation-oriented sustainability research, as well as in adjacent disciplines. With their experimental research agendas, these labs aim at sustainability transformations, however, there is still a need to improve the understanding of their impacts. Drawing from this Special Issue's contributions, we offer a broad overview of the impacts achieved by various real-world labs, highlight the diverse areas and forms of impact, and elucidate strategies as well as mechanisms for achieving impact. We present methodological advances, and address common challenges along with potential solutions for understanding and realizing impact.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
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  • 41
    Publication Date: 2024-01-25
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 42
    Publication Date: 2024-01-25
    Description: Das Bundesministerium für Wissenschaft und Klimaschutz (BMWK) möchte innovationsfreundliche Rahmenbedingungen für Reallabore schaffen. Im Sommer 2023 hat es dazu ein Grünbuch Reallabore veröffentlicht und einen Konsultationsprozess für ein Reallabore-Gesetz eingeleitet. Das Netzwerk Reallabore der Nachhaltigkeit begrüßt die Initiative, sieht aber zugleich erheblichen Gestaltungsbedarf. Die NaWis-Mitglieder unterstützen die hier vorgestellte Position des Netzwerks.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 43
    Publication Date: 2024-01-25
    Description: Für die Landesregierung Nordrhein-Westfalen (NRW) ist die industriell genutzte Kohlenstoffabscheidung und -speicherung (engl. industrial carbon capture and storage, kurz iCCS) ein zentraler Baustein für den Übergang zu einer klimaneutralen Industrie bis 2045. Dafür braucht es aber eine breite gesellschaftliche Akzeptanz - zumal Pläne zur CO2-Abscheidung bei Kohlekraftwerken vor über zehn Jahren schon einmal an mangelnder gesellschaftlicher Akzeptanz gescheitert sind. In diesem In Brief haben die Autor*innen die Ergebnisse von zwei durchgeführten Akzeptanzstudien zu iCCS in NRW zusammengefasst und diskutieren, welche Handlungsempfehlungen sich daraus ergeben.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 44
    Publication Date: 2024-01-25
    Description: Nordrhein-Westfalen (NRW) ist Heimat energieintensiver Industrien wie der Stahl- und Chemieindustrie. Künftig wird grüner Wasserstoff notwendig sein, damit die Industrie in NRW Klimaneutralität erreichen kann. Die Herausforderungen hierbei sind jedoch vielfältig - auch wenn die Akzeptanz für grünen Wasserstoff sowohl in der Gesellschaft als auch bei unmittelbar beteiligten Akteursgruppen hoch ist. Die Autor*innen fassen in diesem In Brief die Ergebnisse von zwei durchgeführten Akzeptanzstudien zu grünem Wasserstoff in NRW zusammen und diskutieren, welche Handlungsempfehlungen sich daraus ergeben.
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  • 45
    Publication Date: 2024-03-13
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  • 46
    Publication Date: 2024-03-13
    Description: Deutschlands Haushalte werden, zu Beheizungszwecken, zu 70 % leitungsgebunden versorgt: 50 % mit Erdgas und 14 % mit Fernwärme; 5 % mit Elektrizität, davon je die Hälfte noch mit Nachtspeicherheizung, die andere Hälfte mit Wärmepumpen. So war es 2021. So wird es in Zukunft nicht sein, denn Erdgas ist ein Energieträger fossiler Herkunft. Dessen Nutzung geht in den nächsten beiden Jahrzehnten gen Null. Die Frage ist, was das für die Erdgasleitungen in Deutschland bedeutet.
    Keywords: ddc:330
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  • 47
    Publication Date: 2024-03-13
    Description: The petrochemical industry is among the most relevant sectors from an economic, energetic and climate policy perspective. In Western Europe, production occurs in local chemical parks that form strongly connected and densely integrated regional clusters. This paper analyzes the structural characteristics of the petrochemical system in Germany and investigates three particularly distinct clusters regarding their challenges and chances for a transition towards climate-neutrality. For this, feedstock and energy supply, product portfolios and process integration as well as existing transformation activities are examined. We find that depending on their distinct network characteristics and location, unique and complex strategies are to be mastered for every cluster. Despite the many activities underway, none of them seems to have a strategic network to co-create a tailored defossilization strategy for the cluster - which is the core recommendation of this paper to develop.
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  • 48
    Publication Date: 2024-03-20
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    Language: German
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  • 49
    Publication Date: 2024-03-20
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  • 50
    Publication Date: 2024-03-20
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  • 51
    Publication Date: 2024-03-20
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  • 52
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    Publication Date: 2024-03-20
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  • 53
    Publication Date: 2024-03-20
    Keywords: ddc:300
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  • 54
    Publication Date: 2024-03-20
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
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  • 55
    Publication Date: 2024-03-20
    Description: Dieses Buch bietet einen Leitfaden für mehr Klimaschutz an Schulen und holt Schulleitungen, Lehrkräfte und Schüler:innen gemeinschaftlich ins Boot - denn Klimaschutz ist eine Gemeinschaftsaufgabe. Mit dem "Whole School Approach" wird die ganzheitliche Umsetzung von Klimaschutzaktivitäten in der Schulentwicklung angestoßen und auf schulischer Ebene ermöglicht und erleichtert. Ziel ist es, Lehrer:innen in ihrer Gestaltungskompetenz für mehr Klimaschutz zu stärken - dies geschieht durch konkrete Vorschläge für die Arbeit mit Schüler:innen im Unterricht. Partizipative Methoden der Beteiligung sollen die Schüler:innen empowern und den Lehrkräften Ideen geben, um die eigene Selbstwirksamkeit, aber auch die der Schüler:innen zu steigern. Die zentrale Kernbotschaft lautet: ein Klimaschutzprojekt an der Schule ist wesentlich für die strukturelle Verankerung von Bildung für nachhaltige Entwicklung im Schulalltag. Der Leitfaden gibt Anregungen für die Unterrichtsgestaltung, Anregungen für die Entwicklung eines Klimaschutzleitbildes, Hinweise für das Gebäudemanagement und Ideen zur Einbindung des schulischen Umfelds.
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  • 56
    Publication Date: 2024-03-20
    Description: Innovative Finanzierungskonzepte wie Solar und Spar-Bürgercontracting belegen, dass ein riesiges Einsparpotenzial an Schulen wirtschaftlich erschlossen werden könnte. Doch bislang passiert zu wenig, um dieses auch zu nutzen. ­Das Projekt Schools4Future zeigt, wie Schulen eigenständig eine CO2-Bilanz erstellen können, um nicht nur eigene Klimaschutzmaßnahmen umzusetzen, sondern auch, um der Politik zu zeigen, wo dringender Handlungsbedarf besteht.
    Keywords: ddc:320
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  • 57
    Publication Date: 2024-03-20
    Description: This paper presents a novel governance concept for sustainable development, introducing the "Safe System Approach" as a transformative model that shifts focus from individual behavioural change to systemic transformation. This approach challenges traditional governance models that emphasize individual responsibility in achieving sustainable development and decarbonization. Instead, it advocates for creating an enabling environment that inherently guides individuals and communities towards sustainable actions. The Safe System Approach is centred on delivering low-carbon services across essential sectors, including electricity, mobility, industry, buildings, human settlements, and agriculture, thereby embedding sustainability as a default choice in societal systems. Drawing parallels with successful models in road safety, the paper explores the potential of this approach in urban development and climate action. It emphasizes the need for a broad coalition and integrated approaches in managing shared resources, highlighting the significance of systemic adjustments over individual behavioral change. By proposing a structure where sustainability is facilitated by the system's design, the paper builds on key concepts from seminal works by scholars like Garrett Hardin, Mancur Olson, Elinor Ostrom, and Ahrend Lijphart. It discusses the challenges and opportunities in creating safe operating spaces for sustainable development, emphasizing the need for multi-actor, multilevel governance systems that can manage shared resources sustainably and are resilient to political volatility. The paper aims to offer a robust, efficient, and inclusive pathway to sustainable development, contributing to the global discourse on environmental and social resilience.
    Keywords: ddc:320
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  • 58
    Publication Date: 2024-03-20
    Description: Angesichts von Extremwetterereignissen, Klimaprognosen und Bewegungen wie Fridays for Future lässt sich schwer leugnen, dass ein Teil der Menschheit auf eine Weise lebt, die eine gut bewohnbare Welt höchst unwahrscheinlich macht. Städten wird in dieser Situation eine zentrale Rolle zugeschrieben. Sie können die Welt vor der Erderwärmung retten - oder sie sind die Ersten, die untergehen. Doch was genau wird getan, um Städte in Richtung Nachhaltigkeit zu transformieren? Britta Acksel nimmt Aktionspläne, Klimafestivals, Awards und weitere Transformationsinstrumente in den Blick. Ethnographisch fundiert zeigt sie auf, wie sich die Arbeit mit dieser speziellen Form von Policy-Werkzeugen gestaltet - und welche Bemühungen besonders aussichtsreich erscheinen.
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    Language: German
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  • 59
    Publication Date: 2024-03-21
    Description: Ways of evaluating the societal impact of real-world labs as a transdisciplinary and transformative research format are under discussion. We present an evaluation approach rooted in structuration theory, with a focus on structure-agency dynamics at the science-society interface. We applied the theory with its four modalities (interpretation schemes, norms, allocative and authoritative resources) to the case of the Mirke neighbourhood in Wuppertal, Germany. Six projects promoted the capacity for co-productive city-making. The effects of the projects were jointly analysed in a co-evaluation process. Previously proposed subcategories of the modalities as an empirical operationalisation were tested and confirmed as being applicable. Five new subcategories were generated. The use of the modalities seems appropriate for co-evaluation processes. The tool is practical, focused on real-world effects, and suitable for transdisciplinary interpretation processes. We encourage further empirical testing of the tool, as well as development of the subcategories.
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  • 60
    Publication Date: 2024-03-21
    Description: Real-world laboratories (RwLs) are gaining further traction as a means to achieve systemic impacts towards sustainability transformation. To guide the analysis of intended impacts, we introduce the concept of leverage points, discerning where, how, and to what end RwLs intervene in systems. Building on conceptual reasoning, we further develop our argument by exploring two RwL cases. Examining RwLs through the lens of the leverage points opens the way for a balanced and comprehensive approach to systemic experimentation. We invite RwL researchers and practitioners to further advance RwLs' transformative capacity by targeting the design and emerging direction of a system, contributing to a culture of sustainability.
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  • 61
    Publication Date: 2024-04-02
    Description: Für Deutschland und viele Industrieländer weltweit wird der Import von grünem Wasserstoff ein zentraler Baustein auf dem Weg zur Klimaneutralität sein. Dabei muss einerseits gewährleistet sein, dass grüner Wasserstoff auch wirklich "grün" im Sinne von klimaneutral ist. Zugleich gibt es immer mehr Forderungen, dass auch andere Nachhaltigkeitskriterien - soziale, ökonomische und ökologische - bei der Produktion und dem Transport von Wasserstoff eingehalten werden. Der politisch getriebene Aufbau einer globalen Wasserstoffwirtschaft bietet von Anfang an die Möglichkeit, diesen Sektor in Einklang mit den bestehenden politischen Zielen zu bringen. Dazu zählen beispielsweise die Pariser Klimaziele oder die Agenda 2030. Die Industrienation Deutschland, die auch in Zukunft auf Energieimporte angewiesen sein wird, kann hier als führende Industrienation als Vorreiter Einfluss nehmen. Damit kann nicht nur sichergestellt werden, dass der nach Deutschland importierte Wasserstoff "grün und nachhaltig" ist, sondern auch die Nachhaltigkeit des globalen Wasserstoffmarktes insgesamt beeinflusst werden. Diese Kurzstudie untersucht, welche bereits existierenden Politikinstrumente geeignet sind, Nachhaltigkeitskriterien für Wasserstoffimporte zu verankern und im Zusammenspiel den Weg zu einem nachhaltigen globalen Wasserstoffmarkt zu unterstützen. Dabei werden ausschließlich Nachhaltigkeitsziele und -kriterien jenseits der Klimawirkung von Wasserstoff analysiert. Es ist unbestritten, dass das zentrale Ziel der Wasserstoffwirtschaft die Reduktion von Treibhausgasen bis hin zur Klimaneutralität ist, was bereits in einer Vielzahl von Studien und Stellungnahmen diskutiert wurde. Daher wird in dieser Studie von der Klimaneutralität des grünen Wasserstoffs ausgegangen, um den Fokus auf die anderen wesentlichen Nachhaltigkeitsaspekte zu lenken, die für den Import von grünem und nachhaltigen Wasserstoff aus dem Globalen Süden von entscheidender Bedeutung sind.
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  • 62
    Publication Date: 2024-04-10
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  • 63
    Publication Date: 2024-05-13
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  • 64
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  • 65
    Publication Date: 2024-05-13
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  • 66
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    Publication Date: 2024-05-13
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  • 67
    Publication Date: 2024-05-13
    Description: Energy performance contracting (EPC) as a market instrument has been effective in promoting energy efficiency worldwide, but it has encountered many insurmountable obstacles in rural energy management. In this study, based on the characteristics of energy management in rural areas, three EPC modes are designed and tested in 24,000 rural households. The test results show that two adapted EPC modes of local government involvement and energy payment directly from the national grid can effectively overcome the barriers encountered in the traditional EPC modes and work well under the economic and social environmental conditions in rural areas. The key to the adaptation of the traditional EPC modes is the introduction of the local government as the third party. Participation of the third party can effectively reduce and remove the barriers and risks and increase the mutual trust between the clients (households) and the energy service companies (ESCOs). Based on the testing results, this study suggests that governmental departments should formulate relevant EPC policies and technical guidelines within the rural context. This research recommends that farmers should not manage their energy services by themselves and it is suggested to out-contracting ESCOs by applying the modes developed and tested by this paper.
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  • 68
    Publication Date: 2024-05-13
    Description: In Germany, there are over 32,000 schools, representing great potential for climate protection. On the one hand, this applies to educational work, as understanding the effects of climate change and measures to reduce GHG emissions is an important step to empower students with knowledge and skills. On the other hand, school buildings are often in bad condition, energy is wasted, and the possibilities for using renewable energies are hardly used. In our "Schools4Future" project, we enabled students and teachers to draw up their own CO2 balances, identify weaknesses in the building, detect wasted electricity, and determine the potential for using renewable energies. Emissions from the school cafeteria, school trips, and paper consumption could also be identified. The fact that the data can be collected by the students themselves provides increased awareness of the contribution made to the climate balance by the various school areas. The most climate-friendly school emits 297 kg whilst the school with the highest emissions emits over one ton CO2 per student and year. Our approach is suitable to qualify students in the sense of citizen science, carry out a scientific investigation, experience self-efficacy through one's own actions, and engage politically regarding their concerns.
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  • 69
    Publication Date: 2024-05-15
    Description: In the race against time, the European Union must move swiftly to navigate the green transition. This imperative isn't just about staying ahead in the global green technology competition; it is about securing the future of Europe's economy while combating climate change. Ahead of the EU elections looming, the urgency of this dual challenge cannot be overstated. With a new pro-EU Polish government in place, the Weimar Triangle - a trilateral forum that brings together Poland, France and Germany - could provide the ideal place to offer a new bold industrial policy leadership in Europe.
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  • 70
    Publication Date: 2024-06-07
    Description: The twenty-eighth Conference of the Parties (COP28) to the United Nations Framework Convention on Climate Change (UNFCCC) in Dubai among many other items concluded the first Global Stocktake (GST) under the Paris Agreement. This article discusses the conference's outcomes in the areas of mitigation, loss and damage, adaptation, climate finance, and cooperation under Article 6 of the Paris Agreement. The conference arguably made history by for the first time ever recognising the need to "transition away" from fossil fuels, adopting specific targets for the scale-up of renewable energy and energy efficiency, and by operationalising a fund to support developing countries in dealing with loss and damage caused by climate change. However, the legal language in the call for an energy transition is relatively non-committal and the conference failed to underpin the new global objectives with adequate resources. Actual implementation of the Dubai outcomes will therefore to a large extent depend on whether COP29 in Baku, Azerbaijan - already billed as "finance COP" - will be able to cut the Gordian knot of finance.
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  • 71
    Publication Date: 2024-06-07
    Description: Aufgrund struktureller Haushaltsprobleme ist in vielen Gebietskörperschaften in den letzten Jahrzehnten im Bereich ihrer Liegenschaften ein immer größer werdender Sanierungsstau entstanden. Das heißt, notwendige Instandsetzungsinvestitionen, Modernisierungen und/oder energetische Sanierungen sind vielerorts unterblieben. Dieses Fachbuch zeigt innovative Lösungen auf.
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  • 72
    Publication Date: 2024-06-07
    Description: North Rhine-Westphalia (NRW) is the industrial center of Germany and one of the most important industrial locations in Europe. It is a key location for the energy-intensive basic materials industry like the production of steel and non-ferrous metals, (petro)chemicals, cement and lime, bricks, glass and ceramics, and paper. Around 20 % of NRW's total greenhouse emissions derive from industrial processes. By 2045, industry must achieve climate-neutrality, which requires a massive transformation effort. Technologically, this needs large-scale utilization of green hydrogen, carbon management, consequent circular economy, and climate-neutral production of process heat. Furthermore, various adjustments to the policy framework are essential.
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  • 73
    Publication Date: 2024-06-07
    Description: The goal of this dissertation is to facilitate the assessment of impacts from sustainable measures and projects with an emphasis on impact reporting for Green, Social or Sustainability Bonds in the Sustainable Finance market. It does so by providing analysts with the means to develop, depict, formulate, and assess a causal hypothesis between an intervention and its subsequent effects in an impact-chain, represented by desired environmental (E), social (S) or governance (G) changes. This is achieved by developing a methodology for so-called ESG Logic Models or ESG-LM, that combine heuristic Theories-of-Change with propositional logic and Bayesian Reasoning. Three research questions are investigated and responded to. Research Question 1 asks how such Theories-of-Change can be developed for any type of ESG-related issue and how the different process steps in a causal chain can be classified, hierarchised, and prioritised regarding their efficacy towards overarching sustainability goals and their plausibility. Research Question 2 studies (a) the means by which the analyst or any other interested third party might be warranted in believing the causal claims from an ESG-LM, and (b) how an ESG-LM can be improved if this credence is low. Research Question 3 then looks at the reporting of impacts themselves regarding indicator selection, indicator assessment and indicator quantification as well as the provision of information on the contributions and attributions by different actors. The dissertation draws on a variety of theories and adapts existing methods to achieve that. It operationalises concepts from empirical Sustainable Finance research and already existing impact assessment methodologies. It adapts scholarly and practitioner approaches for theory-based evaluation and applies a qualitative social science perspective towards theory-building and evaluation, while some of the assessment tools in the dissertation are grounded in Logic, Set Theory and Bayesian Epistemology. Examples for such tools include rules for the Attribution by actors, heuristics for the abduction of plausible outcome pathways, or a four-stage Argument and Decision-Tree to assess the credibility of ESG-LM claims (based on Bayes Theorem). My assessment of the entire methodology is positive overall, as it provides solutions to each of the three research areas. Limitations of the approach, and thus opportunities for further research, are the additional expertise and time required by analysts compared to the existing, and somewhat more pragmatic, solutions in the current market. However, this is outweighed in my opinion by the ability of the framework to strongly mitigate impact washing by actors in the financial markets as well as biases by analysts. Its overall methodology also provides opportunities for new research angles in the area of sustainability indicators and assessments.
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  • 74
    Publication Date: 2024-05-31
    Keywords: ddc:320
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  • 75
    Publication Date: 2024-05-31
    Description: The sustainable transformation of society is one of the greatest challenges of our time. Universities are central actors for knowledge generation and transfer in the sustainability field and, at the same time, are facing the question of how they can become sustainable social actors and make their activities and infrastructure sustainable. Against this background, the 16 member universities of the State Rectors' Conference of North Rhine-Westphalia have joined forces in the Humboldtn initiative to pool their efforts in the field of sustainability and to anchor generational responsibility for sustainable action in research, teaching, administration, infrastructure, and transfer. How the joint responsibility for the questions for the future in the aforementioned complex of topics is addressed via Humboldtn and which focal points are set in the process will be presented and discussed using examples from the institutional sustainability transformation and examples from the research area from RWTH Aachen University. In this way, the implementation of transformation processes at universities and their possible blueprint effect can be illuminated.
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  • 76
    Publication Date: 2024-05-31
    Description: The global building sector, responsible for over 30% of CO2 emissions, necessitates urgent decarbonization efforts. This paper examines residential building decarbonization policies in three major economies - the European Union (EU), China, and India. It provides an overview of diverse policies through policy landscape analysis and delves into the design specifics with a detailed policy intensity analysis of building energy codes, information disclosure, and financial incentives in each region. Our findings reveal a diverse mix of policies targeting residential building decarbonization in all three regions. While the EU and China have long-established diverse policy instruments, India's building energy efficiency policies are relatively recent and limited. Detailed analyses of building energy codes, information disclosure, and financial incentives expose variations in ambition, scope, and implementation, even with shared policy instruments. Significant advancements in building energy codes, particularly in stringency and compliance checks, are evident in the EU and China. Conversely, India faces a notable obstacle with limited adoption of residential building energy codes, impacting its journey towards net-zero. The EU leads in building energy labelling policies, while China and India encounter various challenges hindering widespread implementation. Financial incentives across the three regions predominantly take the form of subsidies, potentially straining public budgets. The study concludes with reflections on the pressing need for future research extending beyond the operational phase of buildings.
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  • 77
    Publication Date: 2024-06-18
    Description: Der Mehrwegverband Deutschland e. V. ist gemeinsam mit dem Wuppertal Institut vom Umweltbundesamt beauftragt worden, die Grundlage für eine gemeinsame Wirkungsmessung der Mehrweg-Rückgabe-Piloten in Deutschland zu legen. Ziel war es, mit Initiator*innen und Beteiligten aus Pilotprojekten deren Ansätze zur Wirkungsmessung zu teilen, zu spiegeln, weiterzuentwickeln - und auf Praxistauglichkeit zu testen. Diese Handreichung gibt einen Überblick über die Projekte, definiert die Gestaltungsdimensionen, beschäftigt sich mit der Wirkungsmessung, zeigt die Ergebnisse auf und gibt erste Empfehlungen. Basis der Erarbeitung war eine Workshop-Reihe der Pilotprojekte in München/Haar, Mainz-Wiesbaden, Hamburg/Westfield, Berlin/Friedrichshain-Kreuzberg und München/Glockenbachviertel.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 78
    Publication Date: 2024-06-25
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 79
    Publication Date: 2024-06-25
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: report , doc-type:report
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  • 80
    Publication Date: 2024-06-25
    Description: Der Abschlussbericht beschreibt den von den Autoren wissenschaftlich betreuten Strategieprozess zur Implementierung und Fortschreibung des Deutschen Ressourceneffizienzprogramms ProgRess während der Projektlaufzeit. Wesentliche Prozesselemente sind ⁠Monitoring⁠ und Evaluation des Programms, die Einbindung von Stakeholdern aus Forschung, Wirtschaft, Politik und Zivilgesellschaft mit Hilfe der NaRess-Plattform und ihrer Arbeitsgruppen sowie die Erstellung zahlreicher Vertiefungsanalysen und Positionspapiere zu aktuellen Themen der Ressourcenpolitik. Die Publikation richtet sich an Entscheidungsträger aus allen Verwaltungsebenen, die ein laufendes Ressourceneffizienzprogramm oder eine vergleichbare rohstoffbezogene Strategie auf den Weg bringen oder begleiten.
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 81
    Publication Date: 2024-06-25
    Description: Dieser Bericht befasst sich mit dem ⁠Monitoring⁠ und der Evaluation von ProgRess III. Der Bericht geht über die Analyse der Ressourceneffizienz auf volkswirtschaftlicher Ebene hinaus und evaluiert insbesondere die Umsetzung der Maßnahmen, die mit ihnen verbundenen Effekte und die zugrundeliegenden Erfolgsfaktoren. Dazu wurde ein zweistufiges Verfahren durchgeführt: ein Monitoring und eine Evaluation des Programms. Nach einer Einführung in die Ziele der Evaluation und der Abgrenzung zum zuvor durchgeführten Monitoring (Kap. 1) werden die Forschungsfragen und die Elemente eines erfolgreichen Politikmix, wie er in der theoretischen Forschung diskutiert und konzipiert wird, kurz erörtert (Kap. 2). Dann werden die Methoden (Analyse, Interviews, Webcrawling) und der Fahrplan der Evaluation vorgestellt (Kap. 3). Zwei Wirkungsmodelle, ein materielles und ein organisationales ⁠Wirkmodell⁠, bilden die Basis für die verschiedenen Betrachtungsebenen und Foki, die für die Evaluation gewählt wurden. In Kapitel 4 werden schließlich die Erkenntnisse, die durch den Einsatz der verschiedenen Methoden gewonnen wurden, in bewusst kompakter und übersichtlicher Form in Bezug zu den Evaluationskriterien dargestellt und Empfehlungen abgeleitet. Kapitel 5 widmet sich der Gesamtbewertung der Effektivität von ProgRess III und Kapitel 6 bearbeitet abschließend die Frage, welche Entwicklungspotenziale aus den gewonnenen Erkenntnissen abgeleitet werden können.
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 82
    Publication Date: 2024-07-03
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: contributiontoperiodical , doc-type:contributionToPeriodical
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  • 83
    Publication Date: 2024-07-03
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 84
    Publication Date: 2024-07-03
    Description: This focus article traces the evolution of the voluntary carbon market (VCM), putting emphasis on the more recent developments following the adoption of the Paris Agreement in 2015. It focuses on the interplay between the privately governed VCM and the global climate regime under the United Nations (UN). For years, the VCM and the UN carbon market operated in parallel and mutually influenced each other. The adoption of the Paris Agreement, however, marked a turning point for the VCM. It triggered the proliferation of net zero targets, sparking the interest in the VCM as a supplier of carbon credits to offset companies' remaining emissions. At the same time, the global scope and ambitious targets set by the agreement have put the future of the VCM in limbo, raising concerns about double claiming and more generally, questioning the adequacy of offsetting. Considering these challenges, numerous stakeholders have started a process to redefine the rules of the market to ensure its credibility and legitimacy. While some areas of convergence were identified, the VCM's private governance has long been unable to address the question of how to deal with double claiming and the claims companies should be allowed to make. In this situation, signals from international policy and regulation under national policy point the way forward for the VCM. By moving from offsetting toward a contribution claim model, the VCM may overcome its "identity crisis" and find a new place within the broader climate change regime.
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 85
    Publication Date: 2024-07-03
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: contributiontoperiodical , doc-type:contributionToPeriodical
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  • 86
    Publication Date: 2024-07-03
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
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  • 87
    Publication Date: 2024-07-03
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 88
    Publication Date: 2024-07-03
    Keywords: ddc:320
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: contributiontoperiodical , doc-type:contributionToPeriodical
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  • 89
    Publication Date: 2024-07-03
    Keywords: ddc:300
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
    Type: contributiontoperiodical , doc-type:contributionToPeriodical
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  • 90
    Publication Date: 2024-07-03
    Description: Die fortschreitende Digitalisierung stellt Unternehmen vor immer neue Herausforderungen und birgt gleichzeitig wichtige Potenziale, unter anderem zur Stärkung des Nachhaltigkeitsmanagements. Hierfür sind jedoch eine gemeinsame Vision und ein Nachhaltigkeitsverständnis grundlegende Voraussetzungen. Dieser Beitrag zeigt am Beispiel des EcoHub-Projekts, wie eine Visionsentwicklung mithilfe des Living-Lab-Ansatzes und der Backcasting-Methode zur erfolgreichen digitalen Veränderung in Unternehmen beitragen und das Nachhaltigkeitsmanagement fördern kann.
    Keywords: ddc:330
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: German
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  • 91
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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  • 92
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 95
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 96
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 97
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 98
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 99
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 100
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
    Keywords: chronic rhinosinusitis ; B-cell lymphoproliferative disorder ; sinus ; nasal allergies ; tannery worker ; Kanpur ; asthma ; ovalbumin ; saffron ; salbutamol ; IL’s ; TNF-α ; allergic rhinitis ; bronchial asthma ; allergy ; Th17 cells ; IL-17 ; IL-33 ; microRNA ; miR ; airway mucosal inflammation ; united airway disease ; acute rhinosinusitis ; acute recurrent rhinosinusitis ; Mediterranean diet ; nutritional evaluation ; nutritional therapy ; olfactory dysfunction ; anosmia ; post-acute COVID-19 ; nitric oxide ; NO ; exhaled NO ; FENO ; nasal peak flow ; atopic status ; total IgE ; specific IgE ; childhood asthma ; immunoblot ; ImmunoCAP ; otolaryngology ; sinusitis ; ethnic groups ; patient-reported outcome measures ; quality of life ; social justice ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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