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  • Q1-390  (1,621)
  • thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general  (856)
  • thema EDItEUR::Q Philosophy and Religion::QD Philosophy  (783)
  • English  (2,760)
  • French  (501)
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  • 1
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    Unknown
    Collège de France
    Publication Date: 2024-04-08
    Description: Depuis une dizaine d’années, les recherches menées sur la nature de la connaissance philosophique, le défi de l’intégration, et la connaissance des essences se sont beaucoup enrichies. En faisant appel à des philosophes engagés sur ces sujets, cet ouvrage se donne pour ambition de faire le point sur ces recherches brûlantes et d’en dégager les perspectives. On s’interrogera sur les relations entre connaissance métaphysique et connaissance philosophique, sur la nature des essences et sur leur connaissance, sur les liens entre essences et modalités, sur la place que joue, pour élucider celles-ci, une réflexion sur l’essentialisme et sur les espèces naturelles, sans oublier la manière dont doit se faire l’articulation entre les formes a priori et a posteriori de la connaissance.
    Keywords: metaphysics ; epistemology ; epistemology of modality ; essence ; bic Book Industry Communication::H Humanities::HP Philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPJ Philosophy: metaphysics & ontology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTJ Philosophy: metaphysics and ontology
    Language: French
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  • 2
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 3
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    Presses universitaires de Vincennes
    Publication Date: 2024-04-05
    Description: Inaugurant la collection « Esthétiques hors cadre », ce premier volume représente un pari : réunir, selon une interrogation commune de l'art, des textes suscités par un projet d'écriture et des études à visée théorique. Comment croiser en esthétique l'acte de la fiction et l'analyse de la réflexion ? C'est à faire jouer la multiplicité des rencontres possibles que s'emploie cet essai, auquel ont contribué des écrivains et des chercheurs de notre modernité. Si la fiction appartient à l'art, c'est par les images qui la portent comme par la diction qui s’y dissimule ; mais si la pensée de l'art se fraie une nouvelle voie aujourd'hui, c'est peut-être dans la mesure où elle reconnaît l'exigence fictive qui l'entraîne. Le pluriel de l’art ne tient-il pas à ce qu'il participe simultanément de la recherche d'un principe et de l'abandon à l'événement ?
    Keywords: B1-5802 ; esthétique ; fiction ; arts ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 4
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    Unknown
    Collège de France
    Publication Date: 2022-02-01
    Description: La théorie de Darwin aussi bien que sa réception scientifique, littéraire et politique en France continuent d’être matière à débat. Les controverses qu’elle a suscitées à partir de la première traduction française de L’Origine des espèces en 1862 n’ont pas été le seul fait des naturalistes, des géologues ou des paléontologues. De nombreux autres savants se sont préoccupés de l’impact du darwinisme sur leur discipline, notamment en philologie, dans les mathématiques, la linguistique, la psychologie comparée, l’histoire ou la philosophie. Les auteurs des textes réunis dans Darwin au Collège de France montrent que le Collège de France constitue un point de référence idéal pour étudier les idées de Darwin et leur réception ainsi que la manière dont elles ont pu jouer sur la formation des disciplines du milieu du xixe siècle jusqu’à aujourd’hui. Parmi les défenseurs ou les adversaires français du darwinisme, on compte en effet plusieurs de ses professeurs, à commencer par Pierre Flourens, dont l’Examen du livre de M. Darwin (1864) a été l’un des premiers comptes rendus hostiles de L’Origine des espèces. D’autres figurent encore dans la liste : Ernest Renan, Edgar Quinet, Théodule Ribot, Jean-Charles Lévêque, Étienne-Jules Marey, Jean-François Nourrisson, Michel Bréal, Gabriel Tarde, Henri Bergson, Étienne Gilson. À cette liste s’ajoutent les professeurs de biologie, de médecine, de paléontologie, de neurosciences, ou d’économie politique. Le colloque, dont les contributions sur quelques-uns des savants mentionnés ci-dessus sont réunies dans le deuxième volume de la collection « Passage des disciplines », a été organisé par Alain Prochiantz et Antoine Compagnon dans le cadre du projet « Passage des disciplines : Histoire globale du Collège de France, xixe siècle - xxe siècle », qui s’intéresse à l’évolution des matières enseignées aussi bien que celles qui ont n’y ont pas été admises et qui forment un « Collège virtuel », depuis la fin du xviiie siècle jusqu’aux années 1960. Il est dirigé par Antoine Compagnon, avec la collaboration de Céline Surprenant et le soutien financier de PSL (2016-2019), et de la Fondation Hugot.
    Keywords: P ; D1-2009 ; PN1-6790 ; B1-5802 ; H1-99 ; Q1-390 ; literary criticism ; biology ; psychology ; history of sciences ; social sciences ; literary history ; higher education ; life sciences ; history of ideas ; philosophy ; research
    Language: French
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: Anthropogenic greenhouse gas (GHG) emissions are dramatically influencing the environment, and research is strongly committed to proposing alternatives, mainly based on renewable energy sources. Low GHG electricity production from renewables is well established but issues of grid balancing are limiting their application. Energy storage is a key topic for the further deployment of renewable energy production. Besides batteries and other types of electrical storage, electrofuels and bioderived fuels may offer suitable alternatives in some specific scenarios. This Special Issue includes contributions on the energy conversion technologies and use, energy storage, technologies integration, e-fuels, and pilot and large-scale applications.
    Keywords: Q1-390 ; QC1-999 ; n/a ; PV ; GHG savings ; lithium-ion battery (LIB) ; probability prediction ; decarbonization ; supercapacitor (SC) ; least squares support vector machine ; EV fleet forecasts ; alternative maritime power (AMP) ; Markov chain ; feasibility study ; D funding ; hybrid power system ; numerical analysis ; ship structure ; optimal sizing ; cellulosic ethanol ; electric vehicles EV ; biofuel ; green ship ; R&amp ; bulk carrier ; molten carbonate fuel cell system ; sparse Gaussian process regression ; power-to-gas ; combination method ; charging infrastructure ; jet fuel ; flow characteristics ; hybrid refinery ; LNG-fueled ship ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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  • 6
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 7
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    Taylor & Francis | Routledge
    Publication Date: 2024-03-23
    Description: Bruno Latour is one of the leading figures in Social Sciences today, but his contributions are also widely recognised in the arts. His theories ‘flourished’ in the 1980s in the aftermath of the structuralism wave and generated new concepts and methodologies for the understanding of the social. In the past decade, Latour and his Actor-Network Theory (ANT) have gained popularity among researchers in the field of architecture. Latour for Architects is the first introduction to the key concepts and ideas of Bruno Latour that are relevant to architects. First, the book discusses critically how specific methods and insights from his philosophy can inspire new thinking in architecture and design pedagogy. Second, it explores examples from architectural practice and urban design, and reviews recent attempts to extend the methods of ANT into the fields of architectural and urban studies. Third, the book advocates an ANT-inspired approach to architecture, and examines how its methodological insights can trace new research avenues in the field, reflecting meticulously on its epistemological offerings. Drawing on many lively examples from the world of architectural practice, the book makes a compelling argument about the agency of architectural design and the role architects can play in re-ordering the world we live in. Following Latour’s philosophy offers a new way to handle all the objects of human and nonhuman collective life, to re-examine the role of matter in design practice, and to redefine the forms of social, political and ethical associations that bind us together in cities.
    Keywords: Actor-Network Theory for Architects;Actor-Network-Theory;Bruno Latour;Cosmos and Cosmopolitics;Invisible Cities;Symmetric Anthropology;Thinkers for Architects ; thema EDItEUR::A The Arts::AM Architecture ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 8
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    Institut Français de Pondichéry
    Publication Date: 2024-04-05
    Description: La tension entre le non-dualisme et le dualisme domine toute l’histoire du Vedanta. En face de l’advaita de Śaṅkara, le système de Madhva, auquel cette étude est consacrée, représente l’extrême dualisme, dvaita. Cependant Madhva, après avoir posé la réalité irréductible de la différence entre Dieu et le monde, a comme compensé cette scission de l’être par l’affirmation que tout être autre que l’Être absolu est dépendant de celui-ci, seul Dieu ne dépendant que de lui-même. L’originalité du système de Madhva est d’inventer une relation nouvelle entre l’Être et les êtres. Seul l’Être est capable de faire exister des êtres différents de lui et totalement dépendants de lui ; Dieu permet à toute réalité d’être, et d’être ce qu’elle est.
    Keywords: B1-5802 ; Vaisnavism ; Dvaita ; Madhva ; Hinduism ; philosophy ; Vedanta ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 9
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    Open Humanities Press
    Publication Date: 2024-04-05
    Description: This book is the first monograph on the theme of “new materialism,” an emerging trend in 21st century thought that has already left its mark in such fields as philosophy, cultural theory, feminism, science studies, and the arts. The first part of the book contains elaborate interviews with some of the most prominent new materialist scholars of today: Rosi Braidotti, Manuel DeLanda, Karen Barad, and Quentin Meillassoux. The second part situates the new materialist tradition in contemporary thought by singling out its transversal methodology, its position on sexual differing, and by developing the ethical and political consequences of new materialism.
    Keywords: metaphysics ; new materialism ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general
    Language: English
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  • 10
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 11
    Publication Date: 2024-04-05
    Description: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Keywords: RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 12
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Keywords: RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 13
    Publication Date: 2024-03-29
    Description: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Keywords: BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Language: English
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  • 14
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    Éditions de la Sorbonne
    Publication Date: 2024-04-05
    Description: Le terme et l'idée de « philosophies de la nature » paraissent renvoyer, strictement et précisément, aux temps et aux œuvres de l'ère postkantienne en Allemagne. Du coup, le concept pourrait en sembler à première vue périmé. Tout se passe comme si l'on avait à faire ici à un chapitre de l'histoire des idées qui serait irrémédiablement antérieur à celui (censément plus récent et plus essentiel) des « philosophies de l'histoire ». Les quelque cinquante contributions réunies dans ce livre tentent de faire ressortir, au contraire, la très grande actualité d'une étude portant sur les « philosophies de la nature ». - L'histoire, au demeurant, est singulièrement mise en question en ces dernières années du XXe siècle, - ce qui met en cause la philosophie de l'histoire en général et ses différentes versions, et du coup encore leur rapport aux philosophies de la nature. En outre, le développement des sciences de la nature ne cesse aujourd'hui de poser (et pas seulement en les reposant) nombre de problèmes philosophiques, tant pratiques que théoriques. La première journée, celle du 20 mars 1994, sous la responsabilité de Paolo Quintili, rassemblait les contributions portant sur la période « de la Renaissance à l'âge classique ». La deuxième, sous la responsabilité de Françoise Dastur, était consacrée le 27 mars aux contributions centrées sur « Kant et l'idéalisme allemand ». C'est sur « Le XIXe siècle » en général qu'a porté la troisième journée, celle du 27 novembre 1994, placée sous la responsabilité d'Hélène Politis. La dernière, sous la responsabilité de Jacques Moutaux, abordait enfin le 4 décembre un large ensemble de questions posées par « Les philosophies de la nature aujourd'hui ».
    Keywords: B1-5802 ; nature ; épistémologie ; philosophie de la nature ; philosophie de l’histoire ; théologie ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Concerns relating to energy supply and climate change have driven renewable energy targets around the world. Marine renewable energy could make a significant contribution to reducing greenhouse gas emissions and mitigating the consequences of climate change, while providing a high-technology industry. The conversion of wave and tidal energy into electricity has many advantages. Individual tidal and wave energy devices have been installed and proven, with commercial arrays planned throughout the world. The wave and tidal energy industry has developed rapidly in the past few years; therefore, it seems timely to review current research and map future challenges. Methods to improve understanding of the resource and interactions (between energy extraction, the resource and the environment) are considered, such as resource characterisation (including electricity output), design considerations (e.g., extreme and fatigue loadings) and environmental impacts, at all timescales (ranging from turbulence to decadal) and all spatial scales (from device and array scales to shelf sea scales).
    Keywords: tide-surge-wave model ; Taiwanese waters ; sea-state hindcast ; wave power ; wave energy ; unstructured grid model ; resource characterization ; WaveWatch III ; SWAN ; tidal energy ; experimental testing ; acoustic Doppler profiler ; Strangford Lough ; dc-dc bidirectional converter ; finite control set-model predictive control (FCS-MPC) ; oscillating water column (OWC) ; supercapacitor energy storage (SCES) ; wave climate variability ; wavelet analysis ; teleconnection patterns ; marine renewable energy ; ocean energy ; environmental effects ; wave modeling ; wave propagation ; numerical modeling ; sediment dynamics ; risk assessment ; marine current energy ; spiral involute blade ; hydrodynamic analysis ; numerical simulation ; wave energy trends ; reanalysis wave data ; Chilean coast ; renewable energy ; wave energy converters ; annual mean power production ; wave energy converter ; transmission coefficient ; absorption ; surfing amenity ; resource ; impact assessment ; feasibility study ; floating offshore wave farm ; WEC ; IRR ; LCOE ; marine energy ; unmanned ocean device ; multi-type floating bodies ; nonlinear Froude-Krylov force ; energy efficiency ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Processing and storage can cause changes and interactions in food components that have effects on nutritional value, organoleptic characteristics or even food safety. This book includes 19 research works showing important and interesting advances, as well as new approaches, in this research topic. Four articles are dedicated to studying the effect of canning conditions (filling media and some ingredients) on the diverse parameters of quality for fish and pet foods. Three articles are devoted to studying the effects of dehydration (pre-treatments and drying procedures). One article is dedicated to monitoring the elaboration of a fermented and dehydrated product (sausage) using a portable NIRS device. The ninth article of this book studies the effect of low-dose electron beam irradiation on cooking quality, moisture migration, and thermodynamics, as well as the digestion properties of the isolated starches in newly harvested and dried rice. The next contribution studies the use of different preservatives to avoid the formation of undesirable volatile organic compounds in stracciatella cheese. Another article examines the impact of source material, kibble size, temperature, and duration on the efficiency of the aqueous extraction of sugars and phenolics from carob kibbles by conventional heat-assisted (HAE) and ultrasound-assisted (UAE) methods. In two articles, marinating with different extracts, alone or combined with other seasoning/conditioning methods, was essayed to tenderize beef or to improve the sensory quality of chicken leg and breast meat. The effect of various cooking methods on the quality, structure, pasting, water distribution and protein oxidation of fish and meat-based snacks is studied in the fourteenth article. The last five articles are dedicated to the study of the effects of storage on several foods (olive oil, blueberry, beetroot and Atlantic mackerel).
    Keywords: Electron Beam Irradiation ; rice ; moisture ; physicochemical properties ; rabbiteye blueberry ; postharvest storage ; firmness ; aroma compounds ; off-odor ; dry-fermented sausages ; near infrared spectroscopy ; portable device ; PLS-DA ; Scomber colias ; prior chilling ; Fucus spiralis ; packaging medium ; canning ; lipid damage ; colour ; trimethylamine ; quality ; carob kibbles ; carob juice ; aqueous extraction ; sugars ; phenolics ; free amino acids ; biogenic amines ; filling medium ; European eels ; stracciatella cheese ; volatile organic compounds ; sensory characteristics ; natural preservatives ; cheese storage ; pineapple by-products ; hydrostatic pressure ; bromelain ; enzyme activity ; marinade ; meat ; texture ; water status and distribution ; microstructure ; secondary structure of protein ; Atlantic mackerel ; saffron quality ; secondary metabolites ; drying ; high performance liquid chromatography-diode array detection (HPLC-DAD) ; spectrophotometry ; canned eels ; olive oil ; sunflower oil ; oxidation ; antioxidants ; total phenols ; vitamin E ; fresh wet noodles ; humidity-controlled dehydration ; microorganisms ; shelf-life ; noodle quality ; “Rocha” pear ; ultrasound ; microwave ; quality characteristics ; empirical models ; beetroot ; organic farming ; storage ; bioactive compounds ; betalain ; nitrate ; sugar ; phenolic compounds ; total dry matter ; chicken meat ; sensory evaluation ; superheated steam ; marination ; hot smoking ; storage effect ; extra virgin olive oil ; phenols ; sterols ; tocopherols ; temperature ; argon ; freeze-thaw cycles ; anthocyanins ; gas chromatography-mass spectrometry ; aroma profiles ; hot-air drying ; blueberry ; cooking methods ; fish meat snacks ; LF-NMR ; SEM ; protein oxidation ; expressible moisture ; gel ; gum ; heat penetration ; thermally processed ; wet pet food ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors
    Keywords: QH301-705.5 ; Q1-390 ; DNMTs ; n/a ; histone modification ; TBRS ; DNA methyltransferases ; autoinhibition ; epigenetics ; DNMT ; cell identity ; embryogenesis ; dwarfism ; DNMT3B ; germ cells ; HSAN1E ; USP7 ; DNMT3A ; DNA methyltransferase ; gene expression ; DNMT1 ; de novo DNA methylation ; DNA methyltransferase structure ; UHRF1 ; DNA methyltransferase mechanism ; allosteric regulation ; rare diseases ; DNA Methylation ; maintenance DNA methylation ; DNA methylation ; ADCA-DN ; PCC/PGL ; ubiquitination ; TETs ; DNA methyltransferase function ; molecular epigenetics ; DNA methyltransferase regulation ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 18
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Keywords: QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This book is motivated by our passion to compile recent research on antimicrobial surfaces. We aimed to assemble research papers on the preparation of new materials, antimicrobial testing using different pathogens (bacteria, fungi, and viruses), and the relationship between the coating nanostructure and its reactivity towards the studied pathogen(s). We believe that a good antimicrobial coating should by characterized by (i) a fast activity towards the pathogen, (ii) sustainable activity based on the stability of the coating, and (iii) the lowest possible toxicity for humans and reduced risks for the environment. Striking a compromise between these different challenges is difficult and requires more research.
    Keywords: active packaging ; chitosan ; methylcellulose ; natamycin ; antimicrobial action ; quaternary ammonium groups ; acrylic acid ; glycidyl methacrylate ; crosslinking reaction ; coating ; edible films ; edible coatings ; antimicrobial agents ; fresh fish ; spoilage ; shelf-life ; black anther disease ; orchid cut flower ; silver nanoparticles ; antifouling efficacy ; flow-through ; triangular box ; Amphibalanus amphitrite ; cuprous oxide ; dynamic aging ; repellant activity ; raft experiment ; bioassay ; biofouling of ships’ hull ; polypropylene ; hernia meshes ; antibacterial ; drug release ; polydopamine ; antimicrobial ; citric acid ; cross-linked ; cold plasma ; antimicrobial activity ; brilliant green ; crystal violet ; demethylation ; lignin ; polyurethane coatings ; triphenylmethane dyes ; 3D printing ; catheters ; dialysis ; extrusion ; infections ; manufacturing ; infection ; coatings ; silver ; nanomaterials ; plasma deposition ; titanium-based thin films ; copper ; magnetron sputtering ; super-elastic coatings ; E. coli inactivation ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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  • 20
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 21
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    IRD Éditions
    Publication Date: 2023-12-20
    Description: Le fleuve Niger constitue un véritable poumon humide pour l’Afrique de l’Ouest et plus spécialement pour la république du Mali. Dans ce pays, la gestion du fleuve constitue un enjeu majeur car on y trouve à la fois de remarquables systèmes de production traditionnels associés au phénomène naturel de crue – sources de moyens d’existence pour des centaines de milliers de personnes – mais aussi de grandes réalisations et promesses en matière d’aménagements modernes, hydroélectriques et hydroagricoles. À l’heure où de nouveaux projets d’équipement arrivent à concrétisation et où d’autres sont annoncés, il est important de faire le point sur l’état de santé de ce fleuve et de peser ce qu’il représente pour ses multiples usagers. Cette expertise collégiale, conduite par l’IRD et l’IER et réalisée avec le soutien de plusieurs institutions d’aide au développement et de défense de l’environnement, traite de ces différents aspects avec pour objectif, d’une part, la clarification des cadres institutionnels et des options de politiques publiques et, d’autre part, le renforcement des outils de suivi et d’aide à la décision.
    Keywords: Q1-390 ; aménagement hydroélectrique ; écosystème ; irrigation ; Niger cours d’eau ; aménagement hydroagricole ; Mali ; exploitation des ressources naturelles ; eau ; bassin versant ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: French
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Anthropogenic and natural disturbances to freshwater quantity and quality are a greater issue for society than ever before. To successfully restore water resources requires understanding the interactions between hydrology, climate, land use, water quality, ecology, and social and economic pressures. This Special Issue of Water includes cutting edge research broadly addressing investigative areas related to experimental study designs and modeling, freshwater pollutants of concern, and human dimensions of water use and management. Results demonstrate the immense, globally transferable value of the experimental watershed approach, the relevance and critical importance of current integrated studies of pollutants of concern, and the imperative to include human sociological and economic processes in water resources investigations. In spite of the latest progress, as demonstrated in this Special Issue, managers remain insufficiently informed to make the best water resource decisions amidst combined influences of land use change, rapid ongoing human population growth, and changing environmental conditions. There is, thus, a persistent need for further advancements in integrated and interdisciplinary research to improve the scientific understanding, management, and future sustainability of water resources.
    Keywords: physical habitat ; aquatic ecology ; stream health ; environmental flows ; land use ; hydrology ; hydroecology ; ecohydrology ; climate change ; Appalachia ; reforestation ; land use-land cover ; land-atmosphere coupling ; water quality ; environmental perceptions ; human dimensions ; spatial models ; socioeconomics ; urban watershed management ; municipal watershed ; water quality impairment ; collaborative adaptive management ; water resources ; urban watersheds ; endocrine disrupting chemical ; opioid ; pathway analysis ; ontology ; metabolomics ; decision-making ; logit regression ; farmer perceptions ; social networks ; public funds ; water conservation adoption ; good governance ; sanitation ; sustainability ; water supply ; water-saving agriculture ; Chinese provincial input efficiency ; three-stage DEA model ; environmental variables ; Boufakrane river watershed ; remote sensing ; LULCC ; water balances ; vulnerability ; total dissolved solids ; drinking water ; Appalachian Mountains ; streamflow sensitivity ; water security ; water balance partitioning ; Budyko ; Escherichia coli ; Suspended particulate matter ; Water quality ; Land use practices ; Watershed management ; basin ; hydrologic model ; reaeration rates ; stream metabolism ; watershed ; physicochemistry ; land use practices ; experimental watershed ; suspended particulate matter ; stream water temperature ; watershed management ; bacteria ; land-use practices ; environmental persistence ; saturated hydraulic conductivity ; pedotransfer function ; model validation ; Chesapeake Bay Watershed ; experimental watershed study ; human dimensions of water ; watershed modeling ; hydrological modeling ; water pollutants ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 23
    Publication Date: 2024-03-27
    Description: This Special Issue provides an insight, collated from 26 articles, focusing on various aspects of the Fit-For-Purpose Land Administration (FFPLA) concept and its application. It presents some influential and innovative trends and recommendations for designing, implementing, maintaining and further developing Fit-For-Purpose solutions for providing secure land rights at scale. The first group of 14 articles is published in Volume One and discusses various conceptual innovations related to spatial, legal and institutional aspects and its wider applications within land use management. The second group of 12 articles is published in Volume Two and focuses on case studies from various countries throughout the world, providing evidence and lessons learned from the FFPLA implementation process.
    Keywords: complete cadastre ; legal element ; fixing boundary ; eligible landowner ; agreement ; boundary marker ; fit-for-purpose land administration (FFP LA) ; violent conflict ; United Nations ; extra-legal ; transitional justice ; peace building ; land governance ; power relations ; securing land rights ; land registration ; development impacts ; fit-for-purpose land administration ; land administration ; decentralization ; India ; fit-for-purpose ; institutions ; governance ; politics ; Amazon ; deforestation ; Fit-For-Purpose land administration ; participatory mapping ; indigenous land conflict ; Cumaribo ; Colombia ; community-based land adjudication ; components of adjudication ; land tenure ; land rights ; good practices ; updating land records ; systematic land registration ; unconventional approach ; case study ; Benin ; cadaster ; land administration domain model ; LADM ; cadastre ; FFPLA ; customary tenure ; land inventory ; land management ; mobile-based applications ; pro-poor ; land surveying ; tenure security ; land rights and tenure ; fit-for-purpose approach ; human rights ; design science research ; design thinking ; fit for purpose ; spatial data quality ; spatial data quality assurance ; maintenance ; update ; upgrade ; upkeep ; renewal ; data quality ; spatial framework ; STDM ; technology ; UAV ; feature extraction ; rapid urbanization ; climate change ; pandemic ; urban resilience ; spatial ; legal ; and institutional frameworks ; land tenure security ; pro-poor land recordation ; land governance reform ; cost effectiveness ; innovative technology ; case studies ; Uganda ; customary land tenure ; land recordation tools ; semantic technologies ; land information system ; fit-for-purpose land management ; aerial and street level imagery ; machine learning ; integrated land programs ; land policy ; pilot study ; informal settlements ; urban development ; Brazil ; community-based crowdsourcing ; SiGIT ; Ecuador ; land and resources rights ; public-private partnerships ; corporate social responsibility ; poverty reduction ; business driven solutions ; social enterprises ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 24
    Publication Date: 2024-04-05
    Description: Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.
    Keywords: QD1-999 ; Q1-390 ; glucose-6-phosphate dehydrogenase ; hydroxyurea/hydroxycarbamide ; n/a ; cord blood ; screening ; hemoglobin pattern ; capillary electrophoresis ; sickle cell disease ; (recommended) screening panel ; vaso-occlusive crisis ; Guthrie spots ; newborn screening) ; foetal haemoglobin ; harmonisation ; review ; birth prevalence ; G6PD deficiency ; prevention ; end-organ damage ; thalassemia ; MALDI-TOF ; IEF ; acute chest syndrome ; India ; sickle cell and thalassaemia screening programme ; ‘Getting to Outcomes’ ; newborn screening ; hemoglobinopathy ; service users ; public health engagement ; automated HPLC ; Kaduna State ; gene therapy for haemoglobinopathies ; ?-globin gene ; methods ; neonatal screening program ; malaria ; Plasmodium vivax ; sub-Saharan Africa ; patient organisations ; health policy ; pathophysiology ; Sickle Cell Disease ; mass spectrometry ; sickle cell disorder ; neonatal screening ; non-tribal ; Nigeria ; point-of-care ; HPLC ; laboratory methods ; registry ; patient advocacy ; bone marrow transplant ; anaemia ; hemoglobinopathies ; tribal ; newborn ; burden of disease ; patient representatives ; diagnostics ; policy making ; haemolysis ; Caribbean ; high performance liquid chromatography (HPLC) ; sickle cell disease (SCD) ; implementation science ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 25
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: During cell metabolism, oxygen is partially reduced to reactive oxygen species (ROS) that play a physiological role in cellular processes. However, an imbalance between the production of ROS and the ability of defenses to detoxify the organism provokes oxidative stress. Oxidative stress and its subsequent damages to vital cellular components have been associated with numerous severe chronic disorders. In addition, oxidation reactions are responsible for food deterioration during processing and storage. Peptides from animal and vegetal food sources have attracted attention due to the large evidence of their in vitro antioxidant properties. In addition to their potential as safer alternatives to synthetic antioxidants used to prevent oxidative reactions in foods, antioxidant peptides can also act by reducing the risk of numerous oxidative stress-associated diseases. Furthermore, peptides can act synergistically with nonpeptide antioxidants, enhancing their protective effect. This Special Issue of the Foods journal includes outstanding papers illustrating examples of the most recent advances on antioxidant peptides from both vegetal and animal sources. The existing data on their bioactivities demonstrated by in silico, in vitro, and animal models are included as well as the mechanisms of action of identified antioxidant peptides.
    Keywords: food peptides ; reactive oxygen species ; antioxidant enzymes ; whey protein hydrolysate ; hydrolysis condition ; food antioxidant ; ORAC ; cellular ROS ; HepG2 ; peptides ; egg white ; egg yolk ; antioxidant peptides ; sarcopenia ; whey protein ; muscle ; C2C12 ; aged animals ; older adult ; exercise ; bioactive peptides ; animal protein ; multifunctionality ; antioxidant activity ; in silico ; cell models ; fruit residues ; antioxidant ; extraction ; albumin ; albumin peptide ; antioxidant peptide ; bioactive peptide ; mung bean ; mung bean albumin ; peptide sequencing ; Vigna radiata ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 26
    Publication Date: 2024-04-05
    Description: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
    Keywords: RC321-571 ; Q1-390 ; non-invasive brain stimulation NIBS ; TMS-EEG ; Transcranial magnetic stimulation TMS ; transcranial electric stimulation tES ; Coregistration ; Near-infrared spectroscopy NIRS ; Functional magnetic resonance imaging fMRI ; transcranial direct current stimulation tDCS ; transcranial alternating current stimulation tACS ; transcranial random noise stimulation tRNS ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 27
    Publication Date: 2024-04-05
    Description: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here.
    Keywords: RC321-571 ; Q1-390 ; posterior cortical atrophy ; Balints syndrome ; optic ataxia ; Posterior parietal cortex ; simultanagnosia ; ocular apraxia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 28
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    Presses universitaires de Vincennes
    Publication Date: 2024-04-05
    Description: Comment s’acquiert la certitude cartésienne ? Par quelle suite d’exercices le doute, l’incertitude, l’ignorance, se changent-ils en un savoir assuré ? Descartes forge pour l’expliquer une « fable » que Doatéa Nuri prend ici décidément au sérieux. Les tribulations, les hésitations, les atermoiements, les incapacités dont font état le Discours de la méthode ou les Méditations métaphysiques sont imputés par elle non à Descartes, mais à un narrateur qu’elle nomme l’Incertain et dont elle brosse le portrait philosophique. Non sans conséquences importantes pour la philosophie elle-même. Car l’incertitude, autre nom de la neutralité, ou de l’anonymat, caractérise aussi bien « l’espace littéraire ». Cette lecture de Descartes, qui cite Blanchot, Deleuze, Foucault, mais fait aussi songer, quand l’Incertain se fait Barbare ou Arpenteur, au Michaux de Plume, ouvre à la pensée un champ illimité, vertigineux, dans lequel la neutralité, virtuellement universelle, est susceptible d’affecter des textes de tous ordres, sans souci d’aucune autorité. L’incertitude n’est pas seulement une hypothèse paradoxale formulée à propos du philosophe réputé le plus clair et le plus assuré ; elle est peut-être la condition de toute pensée.
    Keywords: philosophie ; discours ; doute ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 29
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: As an important tool of systems biology, proteomics has enabled a deep understanding of different plant processes and functions. Complemented with genomic data, computational tools, and improved sample preparation strategies, proteomics has an unprecedented opportunity to characterize plant proteoforms in high spatial and temporal resolution. This special issue of Plant Proteomic Research 4.0 captures the recent advancements in proteomics and addresses the current challenges of plant stress response and resilience in the ever-changing climate. It contains 12 articles, including three reviews and nine original research articles. The three reviews deal with pollen phosphoproteomics, starch biosynthesis-related proteins and posttranslational modifications (PTMs) in rice developing seeds, and PTMs of waxy proteins in rice grain. The nine research articles include three related to temperature, two on water stress, two on salt stress, one on fungal pathogen, and the last one on field-grown potato apoplast proteome. The articles reflect the current frontiers of plant proteomics, focusing on themes of environmental stresses, proteoforms/PTMs, crop species, and new development in data-independent acquisition mass spectrometry. They provide readers insights into current technologies, their utility in understanding plant growth and resilience, as well as directions of proteomics in the frontiers of systems biology and synthetic biology.
    Keywords: peptide markers ; Quercus ilex ; drought tolerance ; targeted post-acquisition proteomics ; plant pathogenesis responses ; quantitative proteomics ; data-independent acquisition ; Phytophthora infestans ; waxy ; amylose ; posttranslational modification ; GBSSI ; rice ; wheat ; salt stress ; physiological characteristics ; ER proteome ; label-free quantitation ; starch biosynthesis ; proteomics ; starch functionality ; cooking and eating quality ; Mesembryanthemum crystallinum ; McHB7 ; transcription factor ; late embryogenesis abundant ; Arabidopsis ; seed germination ; metabolomics ; heat-stable proteome ; dehydrins ; LEA transcripts ; intrinsically disordered proteins ; floral thermogenesis ; Nelumbo nucifera ; DIA-based quantitative proteomics ; time series analysis ; protein-protein interaction network ; WGCNA ; mutant soybean ; flooding ; glycoprotein folding ; fermentation ; cell death ; rice endosperm ; phosphorylation ; high temperature ; sucrose and starch metabolism ; ABPP ; apoplast ; serine hydrolases ; β-glycosidases ; potato ; field-omics ; phosphoproteomics ; pollen tube ; male gametophyte ; root hair ; signal transduction ; kinase motif ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 30
    Publication Date: 2024-04-05
    Description: The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
    Keywords: RC321-571 ; Q1-390 ; Glaucoma ; Visceral Pain ; Calcium ; membrane guanylate cyclase ; ANF-RGC ; Gene Therapy ; Cyclic GMP ; synaptic plasticity ; trafficking ; ROS-GC ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 31
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Introducing “A Feasible Approach for Natural Products to Treatment of Diseases”–an exploration of the therapeutic potential locked within nature’s abundant offerings. This comprehensive reprint delves into the fascinating realm of natural products, uncovering their inherent properties, mechanisms of action, and potential roles in effective disease management. Through extensive scientific research and reviews, the authors shed light on the immense potential of natural products as a viable approach to enhancing health and combating diseases. This reprint presents a diverse and multidimensional exploration, bridging the gap between traditional wisdom and contemporary scientific understanding and offering new avenues for healthcare professionals, researchers, and enthusiasts to harness the power of nature’s remarkable resources. As a catalyst for unlocking the healing potential of natural products, this reprint inspires further investigation and innovation, and drives us towards a future where their integration into mainstream healthcare becomes indispensable. Discover the possibilities and embark on a health and well-being journey with “A Feasible Approach for Natural Products to Treatment of Diseases”.
    Keywords: cancer immunotherapy ; fructan ; FT-IR ; mass spectrometry ; young green barley ; COVID-19 ; β-glucans ; immunomodulation ; anti-inflammation ; anti-oxidant ; ACE2 regulation ; impedance ; ECIS ; antitumor activity ; anticancer properties ; betulin ; betulinic acid ; Amadori rearrangement compounds ; barley ; anti-obesity ; arginyl-fructose ; adipogenic ; ergosta-5,7,22,24(28)-tetraenol (ERGT) ; cholesta-5,7,22,24-tetraenol (CHT) ; ergosterol biosynthesis ; antimetabolite ; suicide substrate ; Trypanosoma brucei ; coronavirus SARS-CoV-2 ; main protease ; Saussurea costus ; molecular docking ; GC-MS profiling ; Molineria recurvata ; diabetic nephropathy ; urinary biomarkers ; inflammation ; oxidative stress ; walnut ; Juglans regia ; high-fat diet ; insulin resistance ; cognitive function ; JNK/NFκB pathway ; Citri Reticulatae Pericarpium ; flavonoids ; anticancer ; mechanism ; phenotype ; Angelica sinensis polysaccharide ; Astragalus membranaceus polysaccharide ; hexokinase 2 ; glycolysis ; JAK2/STAT3 pathway ; liver regeneration ; Holoptelea integrifolia ; MMP-9 ; wound healing ; friedelin ; oxalactam A ; macrolactam ; anti-Rhizoctonia solani ; Penicillium oxalicum ; molecular dynamics ; non-alcoholic fatty liver disease (NAFLD) ; natural products ; terpenoids ; mechanisms ; treatment ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: In recent years, inorganic oxidic nanomaterials have been extensively investigated for their outstanding properties that allow their use within a large variety of raising fields of interest, ranging from (photo)catalysis to the development of functional nanocomposites. Nanoscopic metal (eventually mixed) oxides are often fabricated following soft-chemistry approaches, characterized by the possibility of favouring specific morphologies, particles dimensions, and surface porosities through different synthetic methods and templating processes. In this context, surface functionalities and reactivity play a major role in the determination of nanomaterials final properties. For this reason, further surface functionalization with specific chemical moieties is often recommended to extend their field of application. This Special Issue, now edited as a book, aimed at extending the comprehension of the mechanisms involved in the synthesis and templating of inorganic oxidic nanomaterials, as well as in their surface functionalization and reactivity. Additionally, this Special Issue aimed at increasing the knowledge on the latest advances of these systems in (photo)catalysis, environmental clean-up processes, energy storage, controlled transport and/or release, biomedicine, sensing, development of smart-materials, stimuli-responsive materials, and nanocomposites. Nanomaterials of interest included: silica, alumina, titania, zirconia, zinc oxide, aluminosilicates, iron oxides, perovskites and titanates, rare earth oxides, and composites. Furthermore, particular attention was dedicated toward studies describing alternative ecofriendly preparation methods.
    Keywords: alumino-silicates ; biomedicine ; ceramics ; clays ; inorganic chemistry ; environmental remediation ; nanomaterials ; porous materials ; mesoporous material ; zero-valent-iron nanoparticles ; methylene blue adsorption ; metal–organic framework ; iridium oxide ; nanostructuration ; IrO2 applications ; IrO2 synthesis ; OER ; C3N4 ; ZnO ; heterojunction ; photocatalyst ; metal oxide nanocomposites ; microstructural analysis ; electrospinning ; polymer substrate ; photodegradation ; LSA 99Mo ; thermodynamic parameters ; solid-phase extraction ; isotherm ; metal oxides NPs ; Ni-Fe-TiO2 nanocomposite ; microstructure ; biocompatibility ; endodontic file ; graphitic carbon nitride ; photocatalysts ; g-C3N4/ZnO ; visible light ; photocatalytic degradation ; inorganic coatings ; functional coatings ; stimuli-responsive polymers ; sol–gel ; antimicrobial ; wear-resistance ; photo-catalytic activity ; UV protection ; calcium oxide-doped carbon nitride nanostructures ; basic fuchsine ; elimination mechanism ; π-π stacking ; magnetic nanoparticles ; magnetite ; solvothermal synthesis ; waste valorization ; green chemistry ; advanced oxidation processes ; experimental protocols ; heterogeneous catalysis ; inorganic thermal activation ; organic pollutants ; perovskites ; physico-chemical characterization ; solution combustion synthesis ; strontium ferrates ; water treatment ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PN Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry
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  • 33
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: In 2015, the United Nations decided to establish the goal of achieving “zero hunger” in the world by 2030 through “outcome targets” such as eliminating hunger and improving access to food, ending all forms of malnutrition, promoting sustainable and resilient agriculture, and maintaining genetic diversity in food production. As a result of this decision, strategies are under way in different countries around the world in the form of political, academic, development, and non-governmental organization projects and programs. Five years later, these strategies have certainly generated results that need to be documented and analyzed so as to answer the following questions: what are the progress and success stories in terms of policies, innovations, technologies, and approaches to reach the zero hunger goal? What are the constraints and mitigation strategies? Are we really in a phase of transition towards the zero hunger goal? What new directions do we need to consider to achieve this goal, particularly in the context of the current COVID-19 pandemic, which affects all sectors of development around the world? This book volume will be published within MDPI’s new open access book series entitled “Transitioning to Sustainability”. It welcomes contributions of empirical research, position pieces, and presentations of important research programs or stakeholder initiatives that cover any of the four “outcome targets” of the zero hunger goal. The contributions may come from academics, students, and policy makers of any region in the world and may be related to specific disciplines or be inter and/or transdisciplinary. They may cover areas including but not limited to sustainable improvement of food production, implementing sustainable food and farming systems, improving access to food, limiting malnutrition, limiting food loss and food waste and, finally, global analyses of the challenges of reaching zero hunger in relation to other sustainable development goals as well as success stories on projects, programmes or government initiatives. Transitioning to Zero Hunger is part of MDPI's new Open Access book series Transitioning to Sustainability. With this series, MDPI pursues environmentally and socially relevant research which contributes to efforts toward a sustainable world. Transitioning to Sustainability aims to add to the conversation about regional and global sustainable development according to the 17 SDGs. Set to be published in 2020/2021, the book series is intended to reach beyond disciplinary, even academic boundaries.
    Keywords: Politics ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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  • 34
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The sustainability of water resources worldwide is increasingly imperiled as climate change contributes to the human-induced problems of water supply scarcity and maldistribution. Environmental problems associated with water quality, such as aquifer depletion, land subsidence, the seasonal drying of river flows, waterlogging, the salinization of rivers and groundwater, and human health problems from the excessive use of fertilizers and pesticides will require a radical re-thinking of resource-management policy and new tools to help analysts and regulators craft novel solutions. Over the past several decades, with the advent and rapid progress of computational technology, watershed models have increasingly become important and effective tools for tackling a wide range of water resource and environmental management issues and for supporting regulatory compliance. Statistical and machine-learning methods are being used to support and even supplant more traditional simulation models to improve the estimation of the temporal dynamics and patterns of variability in pollutant concentrations and loads. With the advancements in modeling approaches for water quality, there have also been developments in decision-support tools for water quality management. This reprint describes innovative decision-support approaches from around the world and across sectors that can be applied by stakeholders, government entities, and regulators to reduce environmental pollution and result in cost-effective and sustainable water management strategies.
    Keywords: tree-ring ; flow reconstruction ; pre-development ; estuarine salinity ; salinity intrusion ; water quality forecasting ; decision support ; WARMF ; regression model ; salinity ; irrigated agriculture ; stakeholder involvement ; stream water quality ; CART ; ID3 ; random forest ; bagging ; boosting ; extremely random trees ; Gradient Boosting ; land use factor ; Decision Support System ; water quality forecast ; MLP neural network ; Daubechies 5 wavelet ; long short-term memory network ; hybrid model ; decomposition-and-ensemble ; CE-QUAL-W2 ; EDSS ; SaaS ; irrigation ; agriculture ; policy ; water ; economics ; model ; conservation practices ; decision making ; nutrients ; sediment ; targeting ; water quality ; chemical footprint ; emerging contaminants ; endocrine-disrupting compounds ; footprint calculator ; personal care products ; remote sensing ; geographical information systems ; watershed management ; ambient monitoring ; data collection ; San Joaquin River ; decision support system ; assimilative capacity ; real-time management economics ; drinking water quality ; operational decision-making ; real-time monitoring ; Sacramento-San Joaquin Delta ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology::TQK Pollution control
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  • 35
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Our world is facing many challenges, such as poverty, hunger, resource shortage, environmental degradation, climate change, and increased inequalities and conflicts. To address such challenges, the United Nations proposed the Sustainable Development Goals (SDG), consisting of 17 interlinked global goals, as the strategic blueprint of world sustainable development. Nevertheless, the implementation of the SDG framework has been very challenging and the COVID-19 pandemic has further impeded the SDG implementation progress. Accelerated efforts are needed to enable all stakeholders, ranging from national and local governments, civil society, private sector, academia and youth, to contribute to addressing this dilemma. This volume of the Climate Change and Environmental Sustainability book series aims to offer inspiration and creativity on approaches to sustainable development. Among other things, it covers topics of COVID-19 and sustainability, environmental pollution, food production, clean energy, low-carbon transport promotion, and strategic governance for sustainable initiatives. This book can reveal facts about the challenges we are facing on the one hand and provide a better understanding of drivers, barriers, and motivations to achieve a better and more sustainable future for all on the other. Research presented in this volume can provide different stakeholders, including planners and policy makers, with better solutions for the implementation of SDGs. Prof. Bao-Jie He acknowledges the Project NO. 2021CDJQY-004 supported by the Fundamental Research Funds for the Central Universities. We appreciate the assistance from Mr. Lifeng Xiong, Mr. Wei Wang, Ms. Xueke Chen and Ms. Anxian Chen at School of Architecture and Urban Planning, Chongqing University, China.
    Keywords: climate change ; sustainable development goals ; urban transformation ; decarbonization ; built environment ; governance ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 36
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: In 2020-2022, much of the world was at risk for catching COVID-19. This reprint, “Crimmigration in the Age of COVID-19,” contributes to understanding immigration during the pandemic. It engages a cross-national and interdisciplinary case-study approach to show how countries carved out exceptions to public health protocols for migrants. In the immigration context a variety of governments weaponized public health protocols to criminalize and exclude migrants. The Trump Administration sadistically misplayed the pandemic at almost every turn. Trump came to power on the backs of migrants, referring to them as murderers and rapists. The intersection of Trump’s COVID-19 and migration policies carved out space for the exceptional dehumanization of migrants in 2020-21. This reprint documents the weaponization of public through crimmigration. Crimmigration is the criminalization of migration and migrants via state-of-the-art surveillance and militarized technologies. During the worst of COVID-19, crimmigration strategies--mandatory detention and harsh exclusions— exacerbated the risk of transmission among migrants. Policies not migrants were to blame here. The ostensibly public health related Title42 actually pushed migrants, already at great risk, into unregulated shantytowns controlled by Mexican drug cartels. Additionally, migrants contended with detention facilities, medium security prisons, that functioned as Petrie dishes for the disease. We hope this reprint contributes to understanding the intersection of public health and crimmigration, and border penologies during these exceptional times.
    Keywords: coronavirus ; immigration detention ; migration enforcement ; detention abolition ; detention ; immigration ; human rights ; healthcare ; access to justice ; crimmigration ; deportation ; return ; COVID-19 ; pandemic ; securitisation ; threat prioritisation ; Australia ; New Zealand ; welfare ; exclusion ; surveillance ; attrition ; incarcergration ; decriminalization ; detention standards ; alternatives to detention ; conditions of detention ; COVID ; racial apathy ; white ignorance ; institutional legitimacy ; governing through migration ; The Netherlands ; discourse ; border practices ; asylum seekers ; economic migrants ; Poland ; pushbacks at the border ; COVID-19 pandemic ; governmental xenophobia ; migrants/refugees ; vaccination ; Greece ; n/a ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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  • 37
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    Open Book Publishers
    Publication Date: 2024-04-08
    Description: Having Too Much is the first academic volume devoted to limitarianism: the idea that the use of economic or ecosystem resources should not exceed certain limits. This concept has deep roots in economic and political thought. One can find similar statements of such limits in thinkers such as Plato, Aquinas, and Spinoza. But Having Too Much is the first time in contemporary political philosophy that limitarianism is explored at length and in detail. Bringing together in one place the best writing from key theorists of limitarianism, this book is an essential contribution to political philosophy in general, and theories of distributive justice in particular. Including some of the key published articles as well as new chapters, Having Too Much is necessary reading for scholars and students of political theory and philosophy, as well as anyone interested in questions of distributive justice.
    Keywords: limitarianism;material resources;economic limitarianism;ecological limitarianism;future generations;political thought;distributive justice;intergenerational justice ; bic Book Industry Communication::H Humanities::HP Philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPC History of Western philosophy::HPCF Western philosophy, from c 1900 - ; bic Book Industry Communication::H Humanities::HP Philosophy::HPS Social & political philosophy ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCA Economic theory & philosophy ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNA Environmentalist thought & ideology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHR Western philosophy from c 1800 ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCA Economic theory and philosophy ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNA Environmentalist thought and ideology
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    Publication Date: 2024-04-05
    Description: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.
    Keywords: RC321-571 ; Q1-390 ; Nervous System ; Ion Channels ; Interactome ; cellular signaling ; Protein complexes ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 39
    Publication Date: 2024-04-05
    Description: Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.
    Keywords: QH426-470 ; Q1-390 ; Regional heritability ; prostate cancer ; infectious diseases ; MCMC ; combining studies screening ; conditional-logistic linkage ; Informatics ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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  • 40
    Publication Date: 2022-01-31
    Description: This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
    Keywords: Q1-390 ; small-Hsp ; Hsp60/CCT/BBS ; Indirect/Secondary Chaperonopathies ; Genetic Chaperonopathies ; Hsp40/DnaJ ; chaperonotherapy
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  • 41
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    Éditions de la Sorbonne
    Publication Date: 2024-04-05
    Description: Mikel Dufrenne a croisé les principales problématiques qui ont traversé la seconde moitié du xxe siècle. Il les a considérées avec un regard attentif et critique, soucieux de tracer un chemin singulier mais désireux de s’inscrire dans une tradition de pensée philosophique spécifique et exigeante. La réception de son œuvre pose question : encensée dans les années 1950, elle s’est progressivement réduite en France, notamment vers les années 1970, alors qu’elle fait l’objet aujourd’hui d’un regain d’intérêt. L’étude entend montrer que de telles fluctuations sont liées au malentendu qui fait de Dufrenne l’auteur d’un seul livre, la Phénoménologie de l’expérience esthétique,qui à lui seul ne rend pas compte de l’originalité de sa pensée. Lire Dufrenne, c’est découvrir l’importance de sa réflexion éthique et politique et la stabilité d’une pensée dédiée à la défense des valeurs de « l’humain » et de « l’homme ». C’est aussi se livrer au plaisir de l’élaboration de fictions philosophiques répondant à la tentation de rationaliser une vision du monde par le biais d’une philosophie de la Nature relayée par la notion d’a priori. L’unité de cette œuvre réside dans l’hypothèse d’une Nature artiste que le philosophe veut penser dans le cadre d’une philosophie non théologique.
    Keywords: B1-5802 ; art pour l’art ; philosophie de l'art ; critique et interprétation ; histoire de la philosophie ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 42
    Publication Date: 2024-04-05
    Description: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases.
    Keywords: QR1-502 ; QK1-989 ; Q1-390 ; virus-induced asthma ; Pathology ; respiratory virus ; human immunity ; Epidemiology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: This book brings together recent research related to urban resilience, in particular, taking into account climate change impacts and hydrological hazards. Due to the complexity of our cities, which are vulnerable and continuously evolving systems, urban resilience should be considered as a transversal and multi-sectorial issue, affecting different urban services, several hazards, and all the steps of the risk management cycle. Within this context, the different pieces of research that form this book deal with the topics of multi-risk and urban resilience assessment, analysis of cascading effects, and the proposal and prioritization of adaptation measures and strategies to cope with climate-related hazards through multi-criteria analysis.
    Keywords: RESCCUE project ; Electrical distribution network ; Flooding ; Risk Assessment ; city resiliency ; GIS model ; drought ; water scarcity ; water availability ; climate change ; hydrological modeling ; resilience ; flooding ; hazard mapping ; risk identification ; sustainability ; urban resilience ; traffic modelling ; resilience assessment ; urban services ; cities ; Ecosystem Services (ES) ; Nature-Based Solutions (NBS) ; Resilience Assessment Framework (RAF) ; stakeholders’ validation ; stormwater management and control ; depth‒damage curves ; urban floods ; properties ; claims ; flood expert surveyor ; fluvial ; pluvial ; tidal ; sewer ; flood ; risk ; modelling ; cascading effects ; urban flood ; water quality ; cost-benefit analysis ; combined sewer overflows ; climate change adaptation ; climate risk ; socio-economic assessment ; flood risk assessment ; 1D/2D hydrodynamic model ; Metro system ; subway ; urban mobility ; pluvial floods ; 1D/2D coupled models ; impact assessment ; adaptation strategies ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 44
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: This book is a collection of Special Issue articles with a multidisciplinary character, linking biology, medicine, and synthetic organic chemistry. The synthesis and full characterization of about 180 novel organic species, both of natural and synthetic origin, often designed with the support of in-silico studies, are set out in the book. In several articles, molecular hybridization approaches have been used as a successful multi-target strategy for the design and development of novel antitumor agents. Rigorous and careful biochemical studies ranging from in-vitro experiments on a plethora of human-cancer derived cell lines to in-vivo and ex-vivo studies allowed the authors to identify the molecular targets and gain useful information on structure–activity relationships (SAR). For this reason, this collection should interest many readers from different scientific fields.
    Keywords: thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-08
    Description: This chapter will, first, reconstructs Axel Honneth’s account of the significance of recognition in his book The Struggle for Recognition and track some of the unresolved tensions in it and their role in Honneth’s subsequent work. The final part of the chapter focusses on Honneth’s more recent monograph The Freedom’s Right, in which an oscillation of his position between universalism and historicism or relativism pauses in the latter end. This limits the applicability of the theory outside the confines of Europe or the West. It turns out that the reconstruction and immanent critique of Honneth’s work, however, supports recognition-theoretical universalism.
    Keywords: particularism, personhood, recognition, philosophy, Honneth, universalism ; bic Book Industry Communication::H Humanities::HP Philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPS Social & political philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPC History of Western philosophy::HPCF Western philosophy, from c 1900 - ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHR Western philosophy from c 1800
    Language: English
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  • 46
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth labyrinths to amplify plasma membrane surface area which in turn supports high densities of membrane transporters. Unsurprisingly, therefore, transfer cells are found at key anatomical sites for nutrient acquisition, distribution and exchange. Transfer cells are involved in delivery of nutrients between generations and in the development of reproductive organs and also facilitate the exchange of nutrients that characterize symbiotic associations. Transfer cells occur across all taxonomic groups in higher plants and also in algae and fungi. Deposition of wall ingrowth-like structures are also seen in “syncytia” and “giant cells” which function as feeding sites for cyst and root-knot nematodes, respectively, following their infection of roots. Consequently, the formation of highly localized wall ingrowth structures in diverse cell types appears to be an ancient anatomical adaption to facilitate enhanced rates of apoplasmic transport of nutrients in plants. In some systems a role for transfer cells in the formation of an anti-pathogen protective barrier at these symplastic discontinuities has been inferred. Remarkably, the extent of cell wall ingrowth development at a particular site can show high plasticity, suggesting that transfer cell differentiation might be a dynamic process adapted to the transport requirements of each physiological condition. Recent studies exploiting different experimental systems to investigate transfer cell biology have identified signaling pathways inducing transfer cell development and genes/gene networks that define transfer cell identity and/or are involved in building the wall ingrowth labyrinths themselves. Further studies have defined the structure and composition of wall ingrowths in different systems, leading in many instances to the conclusion that this process may involve previously uncharacterized mechanisms for localized wall deposition in plants. Since transfer cells play important roles in plant development and productivity, the latter being relevant to crop yield, especially so in major agricultural species such as wheat, barley, soybean and maize, understanding the molecular and cellular events leading to wall ingrowth deposition holds exciting promise to develop new strategies to improve plant performance, a key imperative in addressing global food security. This Research Topic presents a timely and comprehensive treatise on transfer cell biology to help define critical questions for future research and thereby generating a deeper understanding of these fascinating and important cells in plant biology.
    Keywords: QK1-989 ; Q1-390 ; Wall ingrowth ; Arabidopsis thaliana ; synctial cells ; Zea mays ; transfer cells ; endosperm transfer cells ; Giant Cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
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  • 47
    Publication Date: 2024-04-05
    Description: Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.
    Keywords: RC321-571 ; Q1-390 ; stress ; Obesity ; Dopamine ; Ghrelin ; Leptin ; Seasonal regulation ; feeding ; HPA axis ; Hypothalamus ; circadian rhythms ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Presses universitaires de Rennes
    Publication Date: 2024-04-05
    Description: Ce livre s’efforce de réparer une injustice : proposer une réflexion d’ensemble sur l’œuvre du philosophe français Mikel Dufrenne (1910-1995) qui semble un peu délaissée voire méconnue aujourd’hui. Si sa démarche phénoménologique héritée de Husserl le conduit immanquablement à s’interroger sur la place singulière que l’objet esthétique occupe dans notre monde, son projet est plus ambitieux. L’attention que Mikel Dufrenne porte aux différents arts (les arts plastiques, la musique, la poésie) ainsi qu’à la richesse des expériences esthétiques vécues, décrites et commentées, lui permet en effet de viser un but supérieur : non seulement redéfinir et réorganiser la phénoménologie autour de la question de l’art, mais faire de l’œuvre ce qui permet de remonter vers un principe originaire, la Nature, qui fonde toute création. Cette tâche singulière et méconnue méritait bien un effort philosophique collectif dont le présent ouvrage est le fruit.
    Keywords: esthétique ; histoire de l'art ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: This Special Issue contains one review and five original articles, all of which address cutting-edge research in the field of water and environmental virology. The review article by Gerba and Betancourt summarizes the current status and future needs for the development of virus detection methods in water reuse systems, especially focusing on methods to assess the infectivity of enteric viruses. Original papers cover a variety of research topics, such as an environmental monitoring survey of group A rotaviruses in sewage and oysters in Japan, the occurrence and genetic diversity of noroviruses and rotaviruses in a wastewater reclamation system in China, the detection of viruses and their indicators in tanker water and its sources in Nepal, integrated culture next-generation sequencing to identify the diversity of F-specific RNA coliphages in wastewater, and the development of a portable collection and detection method for viruses from ambient air and its application to a wastewater treatment plant.
    Keywords: Q1-390 ; reuse ; aerosols ; viral indicator ; wastewater treatment ; microbial contamination ; index virus ; real-time PCR ; tanker water ; virus ; wastewater reclamation ; pathogenic virus ; infectivity ; chlorination ; molecular methods ; wastewater ; next-generation sequencing ; fecal source tracking ; oyster ; fecal-source marker ; viral contamination ; cell culture ; pathogenic microorganisms ; rotavirus ; ultraviolet disinfection ; F-specific RNA bacteriophage strain ; sewage ; waterborne gastroenteritis viruses ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
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  • 50
    Publication Date: 2024-04-05
    Description: euromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
    Keywords: RC321-571 ; Q1-390 ; Informed Consent ; Deep Brain Stimulation ; Depression ; Neurosurgery ; Movement Disorders ; Neuromodulation ; Enhancement ; Neuroethics ; Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 51
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: This Special Issue explored different topics concerning recent progress in the synthesis and characterization of suitable innovative macromolecular systems, proposed as carriers of specific antimicrobial molecules, to be employed in the biomedical and pharmaceutical fields. Many infectious diseases are induced by omnipresent micro-organisms, including bacteria, viruses, protozoa, fungi, and algae, and, consequently, are very common, accounting for a significant share of the global disease burden. Unfortunately, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this issue lies in improving the existing antimicrobial delivery systems. In this regard, nanoparticles as well as three-dimensional hydrophilic systems represent valuable tools able to ensure excellent performances. Biocompatible polymeric particles, entrapping these bioactive molecules, are capable of releasing them over a desired period of time, thereby decreasing the frequency of their administration. At the same time, these systems are able to protect antimicrobial drugs from degradation, enhancing their bioavailability. This Special Issue serves to highlight and capture the contemporary progress recorded in this field.
    Keywords: film nanocomposite ; essential oil ; supercritical CO2 ; long-term package ; hybrid nanoparticles ; biocompatible polymer ; antimicrobial amphiphiles ; dynamic light scattering ; scanning electron microscopy ; cell viability from counting of colony-forming unities ; antimicrobial activity of nanoparticles ; Escherichia coli ; Staphylococcus aureus ; Candida albicans ; hydrogel ; polyvinyl alcohol ; aliphatic dicarboxylic acids ; sustained release ; linezolid ; equilibrium swelling ratio ; accumulative release ; thermogravimetric analysis ; gram-negative bacteria ; multidrug resistance ; polymer therapeutics ; colistin ; polymyxin B ; nanoliposomes ; MDR-Bacteria ; chitosan ; nanotechnologies ; plant extracts ; agro-food-wastes ; antimicrobial agents ; polymeric nanocarriers ; mixed polymeric micelles ; drug delivery ; antibiotics ; Pluronic F127 ; antimicrobial agent ; polymeric nanomaterial ; self-assembly ; antimicrobial peptide ; silver nanoparticle ; anti-biofilm ; wound healing ; bromelain ; nisin ; bioactivity ; biomedicine ; carrier ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 52
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    Taylor & Francis | The Routledge Handbook of Philosophy and Improvisation in the Arts | Routledge
    Publication Date: 2024-04-05
    Description: The idea of improvisation, broadly defined, has been integral to our imagination of the medieval musical past. It can be related to many elements of production: to the act of un-notated creation; to the manipulation and amplification of notated materials; to our observance of rigid rules and formulae; or to spontaneous freedom. Likely a product of the Carolingian Renaissance, this is the first medieval music treatise to address an aspect of chant performance that does not only relate to a memorized repertoire, but includes an unwritten practice of extemporizing an accompanying voice to a pre-given melody. The art of “coloration” or the ornamentation of a line, whether polyphonic or monophonic, had been an integral part of extemporization since at least the time of the Ad organum faciendum treatises. When planning author's ontological inquiries, the author's would do well to remember the possible existence of creativity that is not inspired, or ephemerality that is not performer- or expression-centered.
    Keywords: Philosophy, Ontology, Music, Improvisation, Arts, Performance ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 53
    Publication Date: 2024-03-29
    Description: The integration of multisensory information is an essential mechanism in perception and in controlling actions. Research in multisensory integration is concerned with how the information from the different sensory modalities, such as the senses of vision, hearing, smell, taste, touch, and proprioception, are integrated to a coherent representation of objects. Multisensory integration is central for action control. For instance, when you grasp for a rubber duck, you can see its size and hear the sound it produces. Moreover, identical physical properties of an object can be provided by different senses. You can both see and feel the size of the rubber duck. Even when you grasp for the rubber duck with a tool (e.g. with tongs), the information from the hand, from the effect points of the tool and from the eyes are integrated in a manner to act successfully. Over the recent decade a surge of interest in multisensory integration and action control has been witnessed, especially in connection with the idea that multiple sensory sources are integrated in an optimized way. For this perspective to mature, it will be helpful to delve deeper into the information processing mechanisms and their neural correlates, asking about the range and constraints of this mechanisms, about its localization and involved networks.
    Keywords: BF1-990 ; Q1-390 ; recalibration ; haptic ; Human Information Processing ; Vision ; Perception ; reference frame ; Acoustics ; Tool Use ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 54
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    Mohr Siebeck | Mohr Siebeck GmbH & Co. KG
    Publication Date: 2024-04-08
    Description: Reflections on God, Christ and cosmos in the writings of Paul and the Pauline School show that these authors were familiar with important notions from Graeco-Roman cosmology and theology. George van Kooten comes to the conclusion that they might even have adopted a way of thinking in which Judaism and Graeco-Roman cosmology were forged into a new synthesis, and Christ was viewed as a cosmic god. In this development, Paul and the authors of the Pauline School took up various positions which were all represented in contemporary discussions about God and cosmos in the philosophical schools. Against this background this study also sheds new light on the specific relationship between Colossians and Ephesians.
    Keywords: Philosophy ; Religious ; Philosophy ; History & Surveys ; Philosophy ; Essays ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general::HRAB Philosophy of religion ; bic Book Industry Communication::H Humanities::HP Philosophy::HPC History of Western philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAB Philosophy of religion ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 55
    Publication Date: 2024-04-05
    Description: Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by linking neural activity, recorded invasively or noninvasively, to external devices, such as arm prostheses, exoskeletons that enable bipedal walking, means of communication and technologies that augment attention. In addition to many practical applications, BMIs provide useful research tools for basic science. Several articles cover challenges and controversies in this rapidly developing field, such as ways to improve information transfer rate. BMIs can be applied to the awake state of the brain and to the sleep state, as well. BMIs can augment action planning and decision making. Importantly, BMI operations evoke brain plasticity, which can have long-lasting effects. Advanced neural decoding algorithms that utilize optimal feedback controllers are key to the BMI performance. BMI approach can be combined with the other augmentation methods; such systems are called hybrid BMIs. Overall, it appears that BMI will lead to many powerful and practical brain-augmenting technologies in the future.
    Keywords: RC321-571 ; Q1-390 ; microcircuits ; Brain machine interface (BMI) ; nootropics ; tDCStranscranial direct current stimulation ; neural networks ; neuroprosthesis ; TMS ; implants ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    KIT Scientific Publishing
    Publication Date: 2024-04-05
    Description: August Ludwig Hülsen (1765-1809) was a contributor to the emergence of German idealism. Notwithstanding, his name and works are up to this day almost entirely unknown to most scholars in the field. This monograph discusses the historical importance of Hülsen's Prüfung der von der Akademie der Wissenschaften zu Berlin aufgestellten Preisfrage: Was hat die Metaphysik seit Leibniz und Wolf für Progressen gemacht? (1796), his only book, for the emergence of German idealism, especially the thought of Reinhold and Fichte during the 1790's. The usual way of focusing on the Wissenschaftslehre, and hence, on the emergence of German idealism, is as a “response” of Fichte to the skeptical objections of Schulze-Aenesidemus to Reinhold's early Elementarphilosophie. This “response”, as Fichte himself recognized in 1798, was far from complete. Hülsen, a Fichtean thinker, restructured and regrounded those aspects of Reinhold's system that Fichte left intact: in particular, Reinhold's almost forgotten approach to the rational history of philosophy. In 1797, Hülsen's achievement prompted Fichte's recommendation of Hülsen's book in Annalen des philosophischen Tons as an introduction to his Wissenschaftslehre. This indicates that Fichte recognized Hülsen as a partner in the development of his incomplete system. Accordingly, the historical importance of Hülsen's book is that it completed Fichte's attempt to overcome Reinhold's standpoint and contributed to the emergence of German idealism.
    Keywords: German Idealism ; August Ludwig Hülsen ; Johann Gottlieb Fichte ; Karl Leonhard Reinhold ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Photovoltaic (PV) and concentrated solar power (CSP) systems for the conversion of solar energy into electricity are technologically robust, scalable, and geographically dispersed, and they possess enormous potential as sustainable energy sources. Systematic planning and design considering various factors and constraints are necessary for the successful deployment of PV and CSP systems. This book on solar power system planning and design includes 14 publications from esteemed research groups worldwide. The research and review papers in this Special Issue fall within the following broad categories: resource assessments, site evaluations, system design, performance assessments, and feasibility studies.
    Keywords: thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Open data and policy implications coming from data-aware planning entail collection and pre- and postprocessing as operations of primary interest. Before these steps, making data available to people and their decision-makers is a crucial point. Referring to the relationship between data and energy, public administrations, governments, and research bodies are promoting the construction of reliable and robust datasets to pursue policies coherent with the Sustainable Development Goals, as well as to allow citizens to make informed choices. Energy engineers and planners must provide the simplest and most robust tools to collect, process, and analyze data in order to offer solid data-based evidence for future projections in building, district, and regional systems planning. This Special Issue aims at providing the state-of-the-art on open-energy data analytics; its availability in the different contexts, i.e., country peculiarities; and its availability at different scales, i.e., building, district, and regional for data-aware planning and policy-making. For all the aforementioned reasons, we encourage researchers to share their original works on the field of open data and energy analytics. Topics of primary interest include but are not limited to the following: 1. Open data and energy sustainability; 2. Open data science and energy planning; 3. Open science and open governance for sustainable development goals; 4. Key performance indicators of data-aware energy modelling, planning, and policy; 5. Energy, water, and sustainability database for building, district, and regional systems; 6. Best practices and case studies.
    Keywords: data envelopment analysis ; Kohonen self-organizing maps ; factor analysis ; multiple regression ; energy efficiency ; social media ; energy-consuming activities ; energy consumption ; machine learning ; ontology ; energy performance certificate ; heating energy demand ; buildings ; data mining ; classification ; regression ; decision tree ; support vector machine ; random forest ; artificial neural network ; open data ; electrification modelling ; Malawi ; OnSSET ; MESSAGEix ; reproducibility ; collaborative work ; open modelling and data ; data-handling ; integrated assessment modelling ; data pre- and post-processing ; space heating ; domestic hot water ; market assessment ; EU28 ; district heating ; data analytics ; big data ; forecasting ; energy ; polygeneration ; clustering ; kNN ; pattern recognition ; heating ; building stock ; heat map ; spatial analysis ; heat density map ; building performance simulation ; parametric modelling ; energy management ; model calibration ; Passive House ; energy planning ; energy potential mapping ; urban energy atlas ; urban energy transition ; energy data ; data-aware planning ; spatial planning ; open data analytics ; smart cities ; open energy governance ; urban database ; energy mapping ; building dataset ; energy modelling ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 59
    Publication Date: 2024-04-05
    Description: Photosystem II is a 700-kDa membrane-protein super-complex responsible for the light-driven splitting of water in oxygenic photosynthesis. The photosystem is comprised of two 350-kDa complexes each made of 20 different polypeptides and over 80 co-factors. While there have been major advances in understanding the mature structure of this photosystem many key protein factors involved in the assembly of the complex do not appear in the holoenzyme. The mechanism for assembling this super-complex is a very active area of research with newly discovered assembly factors and subcomplexes requiring characterization. Additionally the ability to split water is inseparable from light-induced photodamage that arises from radicals and reactive O2 species generated by Photosystem II chemistry. Consequently, to sustain water splitting, a “self repair” cycle has evolved whereby damaged protein is removed and replaced so as to extend the working life of the complex. Understanding how the biogenesis and repair processes are coordinated is among several important questions that remain to be answered. Other questions include: how and when are the inorganic cofactors inserted during the assembly and repair processes and how are the subcomplexes protected from photodamage during assembly? Evidence has also been obtained for Photosystem II biogenesis centers in cyanobacteria but do these also exist in plants? Do the molecular mechanisms associated with Photosystem II assembly shed fresh light on the assembly of other major energy-transducing complexes such as Photosystem I or the cytochrome b6/f complex or indeed other respiratory complexes? The contributions to this Frontiers in Plant Science Research Topic are likely to reveal new details applicable to the assembly of a range of membrane-protein complexes, including aspects of self-assembly and solar energy conversion that may be applied to artificial photosynthetic systems. In addition, a deeper understanding of Photosystem II assembly — particularly in response to changing environmental conditions — will provide new knowledge underpinning photosynthetic yields which may contribute to improved food production and long-term food security.
    Keywords: QK1-989 ; Q1-390 ; Arabidopsis thaliana ; photoactivation ; photosynthesis ; Chlamydomonas reinhardtii ; cyanobacteria ; biogenesis ; Photosystem II ; photodamage ; Nicotiana tabacum ; Synechocystis sp. PCC 6803 ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
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  • 60
    Publication Date: 2024-04-05
    Description: Big data is revolutionizing our ability to measure and study the human brain. New technology increases the resolution of images that are being study as well as enables researchers to study the brain as it functions. These technological advances are combined with efforts to collect neuroimaging data on large numbers of subjects, in some cases longitudinally. This combination of advances in measurement and scope of studies requires novel development in the statistical analysis. Fast, scalable, robust and accurate models and approaches need to be developed to make headway on these problems. This volume represents a unique collection of researchers providing deep insights on the statistical analysis of big neuroimaging data.
    Keywords: RC321-571 ; Q1-390 ; fMRI ; Neuroscience ; functional connectivity ; EEG ; Classification ; prediction ; big data ; MEG ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 61
    Publication Date: 2024-03-29
    Description: A conversation between two people can only take place if the words intended by each speaker are successfully recognized. Spoken word recognition is at the heart of language comprehension. This automatic and smooth process remains a challenge for models of spoken word recognition. Both the process of mapping the speech signal onto stored representations for words, and the format of the representation themselves are subject to debate. So far, existing research on the nature of spoken word representations has focused mainly on native speakers. The picture becomes even more complex when looking at spoken word recognition in a second language. Given that most of the world’s speakers know and use more than one language, it is crucial to reach a more precise understanding of how bilingual and multilingual individuals encode spoken words in the mental lexicon, and why spoken word recognition is more difficult in a second language than in the native language. Current models of native spoken word recognition operate under two assumptions: (i) that listeners’ perception of the incoming speech signal is optimal; and (ii) that listeners’ lexical representations are accurate. As a result, lexical representations are easily activated, and intended words are successfully recognized. However, these assumptions are compromised when applied to a later-learned second language. For a variety of reasons (e.g., phonetic/phonological, orthographic), second language users may not perceive the speech signal optimally, and they may still be refining the motor routines needed for articulation. Accordingly, their lexical representations may differ from those of native speakers, which may in turn inhibit their selection of the intended word forms. Second language users also have to solve a larger selection challenge—having words in more than one language to choose from. Thus, for second language users, the links between perception, lexical representations, orthography, and production are all but clear. Even for simultaneous bilinguals, important questions remain about the specificity and interdependence of their lexical representations and the factors influencing cross-language word activation. This Frontiers Research Topic seeks to further our understanding of the factors that determine how multilinguals recognize and encode spoken words in the mental lexicon, with a focus on the mapping between the input and lexical representations, and on the quality of lexical representations.
    Keywords: BF1-990 ; Q1-390 ; Phonological knowledge ; Second-language speech ; bilingual and bidialectal lexicon ; spoken word recognition ; lexical access ; orthographic knowledge ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 62
    Publication Date: 2024-03-31
    Description: This forum of comprehensive reviews and research studies on distinct aspects of the pathophysiology of BAV aortopathy provides both the state of the art in the knowledge on this complex disease and novel insights into its causes and consequences. The present collection of focused papers also envisions and proposes new therapeutic strategies, novel biomarkers and original risk stratification criteria, for the improvement of patient management.
    Keywords: QP1-981 ; Q1-390 ; smooth muscle cells ; microRNAs ; aortic root ; endothelial cells ; aortic surgery ; bicuspid aortic valve ; 4DFlow analysis ; aortopathy ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 63
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The diversity of wood and non-wood forest products is enormous and reflected in their anatomical, physical and chemical properties as well as their potential applications. Special attention should be given to lesser-known species and even to invasive species, which may be profitable when properly managed, thereby decreasing the overexploitation of threatened species. Besides the market importance of stem wood, other tree components and non-wood forest products, often regarded simply as forest residual materials, are valuable forest resources with various potential applications that can strengthen the circular economy. Assessing the characteristics of these diverse materials, such as their structure and anatomy as well as their physical and chemical properties, is fundamental for evaluating their potential and increasing high-quality end-uses. This knowledge will also contribute to sustainable forest management with enhanced forest diversity and species conservation in addition to the reinforcement of certification and environmental policies.
    Keywords: Calamus zollingeri ; Calamus ornatus ; dynamic vapor sorption ; basic density ; volumetric swelling ; white rot ; mold ; Quercus suber L. ; seasonal variation ; cuticular waxes ; leaves ; new species ; morphology ; wood ; properties ; chemical composition ; spectroscopy ; chemometrics ; unconventional species ; Quercus suber ; cork borer ; cork ; phenolics ; tropical species ; wood anatomy ; wood density ; wood color ; multivariate analysis ; species diversity ; dark-brown zone ; lenticular filling tissue ; quantitative anatomical characteristics ; Quercus variabilis ; reproduction cork ; scanning electron microscopy ; sclereid ; virgin cork ; Cytisus scoparius ; liquefied ; optimization ; eco-valorization ; agro-industrial residues ; Asparagaceae ; lignocellulose ; crystalline cellulose ; syringyl/guaiacyl ; anatomy ; Tilia amurensis Rupr. ; Tilia mandshurica Rupr. & Maxim. ; branch ; wood properties ; papermaking material ; tropical timber ; color parameters ; mid-infrared spectroscopy ; FTIR ratios ; environmental factors ; West African Sahel ; Cupressus funebris Endl. wood ; wood knots ; physical properties ; wood color properties ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNA Agribusiness and primary industries::KNAL Forestry industry
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  • 64
    Publication Date: 2024-03-29
    Description: This research topic stems from the "Interdisciplinary Approaches to Multilingualism" conference, which was hosted by the Language Research Centre at the University of Calgary. It was the first conference of its kind, which brought together the work of researchers, educators, and policy makers in the areas of first and second language acquisition from psycholinguistic and pedagogical perspectives. The goal was to provide an opportunity for participants to engage with the implications of multilingualism from a range of perspectives, including the effects of being bilingual from infancy to adulthood, the process and benefits of learning multiple languages, and the impact of multilingualism on society.
    Keywords: BF1-990 ; Q1-390 ; Developmental psycholinguistics ; second language literacy development ; Multilingualism ; psycholinguistic research methods ; Second language pedagogy ; bilingualism ; Second Language Acquisition ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 65
    Publication Date: 2024-04-05
    Description: The world we live in is unjust. Preventable deprivation and suffering shape the lives of many people, while others enjoy advantages and privileges aplenty. Cosmopolitan responsibility addresses the moral responsibilities of privileged individuals to take action in the face of global structural injustice. Individuals are called upon to complement institutional efforts to respond to global challenges, such as climate change, unfair global trade, or world poverty.  Committed to an ideal of relational equality among all human beings, the book discusses the impact of individual action, the challenge of special obligations, and the possibility of moral overdemandingness in order to lay the ground for an action-guiding ethos of cosmopolitan responsibility.  This thought-provoking book will be of interest to any reflective reader concerned about justice and responsibilities in a globalised world.  Jan-Christoph Heilinger is a moral and political philosopher. He teaches at Ludwig-Maximilians-Universität, Munich, Germany, and at Ecole normale supérieure, Port-au-Prince, Haiti.
    Keywords: B1-5802 ; cosmopolitanism ; global justice ; social justice ; equity ; responsibilty ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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  • 66
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: “Personalised Nutrition” represents any initiative that attempts to provide tailor-made healthy eating advice based on the nutritional needs of each individual, as these are dictated by the individual’s behaviour, phenotype and/or genotype, and their interactions. This Special Issue of Nutrients is dedicated to the development, implementation and assessment of the effectiveness of evidence-based “Personalised Nutrition” strategies. In this regard, a selection of reviews and original research manuscripts will bring together the latest evidence on how lifestyle habits, physiology, nutraceuticals, gut microbiome and genetics can be integrated into nutritional solutions, specific to the needs of each individual, for maintaining health and preventing diseases.
    Keywords: QH301-705.5 ; Q1-390 ; TX341-641 ; n/a ; gene-based ; taste ; postprandial leptin ; children ; personalised ; obesity ; macronutrient composition ; gastrointestinal symptoms ; postprandial adiponectin ; formula diet ; avoidance diet ; weight loss ; weight ; omega-3 fatty acids ; microbiome ; genotype ; nutrition ; direct-to-consumer test ; intervention ; clinical nutrition ; postprandial total ghrelin ; dietary intervention ; microbiota ; low-carbohydrate diet ; insulin ; FADS polymorphism ; adults ; genetics ; diet ; healthcare professionals ; HbA1c ; PROX1 gene ; phenotype ; high-fat meal ; glucose ; personalised nutrition ; irritable bowel syndrome ; dietary recommendation ; postprandial metabolic fingerprinting ; type 2 diabetes mellitus risk ; high-carbohydrate meal ; health ; ultra-high performance liquid chromatography ; food allergy ; normo-carbohydrate meal ; nutrimetabolomics ; type 2 diabetes ; nutrigenetics ; gene–diet interaction ; personalized nutrition ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: New scientific advances in different areas have allowed the design of more precise strategies for the prevention and treatment of metabolic disorders through nutrition. In this context emerges the term Precision Nutrition, a new approach that takes advantage of scientific knowledge about the interaction of internal and external environmental factors to develop dynamic and precise nutritional recommendations. Therefore, Precision Nutrition includes personalized advice based on genetics and well-documented gene–nutrient–phenotype interactions, as well as other factors such as individual metabolome, transcriptome, and microbiota profile; food behavior; and dietary, physical activity, and life-style habits; and the resulting interactomes. Precision Nutrition should be based at least on three sequential steps: conventional nutritional approaches (considering age, gender, and physiological states); the incorporation of nutritional and health status information (e.g., metabolites, physical and nutritional behavior); and the genetic baggage including multiomics functional integration.
    Keywords: dietary parameters ; carbohydrate intake ; obesity ; single nucleotide polymorphism ; CLOCK gene ; rs3749474 ; sodium intake ; hypertension ; single-nucleotide polymorphism ; personalized nutrition ; dietary vitamin A ; body fat ; UCP ; retinoic acid ; PBMC ; genetic variant ; weight loss ; nutrigenomics ; dietary intervention ; FTO gene ; dietary protein ; dietary carbohydrates ; dietary fat ; macronutrients ; gene-diet interaction ; glucose homeostasis ; glaucoma ; polygenetic-risk scores ; gene-gene interaction ; gene-nutrient interaction ; precision medicine ; childhood ; insulin resistance ; adipokine ; metabolomics ; biomarkers ; ELOVL ; metabolic alterations ; Mexican population ; Single Nucleotide Polymorphisms ; pediatrics ; cardiometabolic risk factors ; precision nutrition ; eating behavior ; nutrigenetics ; microbiota ; metabolic syndrome ; Mediterranean diet ; genetic risk score ; HELENA ; adolescents ; sex ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC4 Cultural studies: food and society
    Language: English
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  • 68
    Publication Date: 2024-04-05
    Description: In the last decade, sleep spindles have attracted steadily increasing attention. This interest is motivated by the many intriguing relationships between spindles and various diseases (e.g., schizophrenia, Parkinson, Alzheimer, autism, mental retardation), recovery processes (e.g., post brain stroke), and cognitive faculties (e.g., memory consolidation, intelligence, dream recall, sleep preservation). Nonetheless, a methodological wall has impeded the study of sleep spindles. Their investigation rests heavily on our ability to reliably and consistently identify spindle patterns from background EEG activity, a task involving many obstacles, including: a fuzzy definition of spindles, low inter-expert agreement on their scoring, lack of consensus on standard techniques for their automated detection, low reproducibility of observed characteristics and correlates, unavailability of large, standardized, high-quality databases, and inconsistencies in the methods used to evaluate the performance of automated detectors. The primary aims of this research topic were to bring together world-class researchers on a project designed to facilitate exchanges on methodological difficulties encountered in assessing sleep spindles and to promote standardized spindle-related resources. In preparing their contributions, authors were encouraged to use existing – or to propose new – publicly available resources for assessing sleep spindles. To allow fair and accurate comparison of reported results, the authors were also encouraged to validate their tools on a common benchmark. A database containing expert spindle scoring (i.e., the Montreal Archive of Sleep Studies) was made publicly available for that purpose.
    Keywords: RC321-571 ; Q1-390 ; Neural oscillations ; Electroencephalography (EEG) ; Sleep ; Sleep Spindles ; Memory ; IQ ; sigma waves ; automatic detection ; biomarker ; Open access ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 69
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    Presses universitaires du Septentrion
    Publication Date: 2024-04-05
    Description: La première édition de La Naissance du paradigme herméneutique remonte à 1990. Depuis, la discussion autour de l’histoire de l’herméneutique et des enjeux qui lui sont liés tant du côté de la philosophie que des sciences interprétatives s’est considérablement développée. L’objet de cette seconde édition n’est pas de prendre position dans ce débat. Le volume reste conçu comme un recueil de matériaux devant faciliter la réévaluation du moment où la théorie herméneutique, à la fin du xviiie siècle, subit un changement d’orientation radical, dont l’un des principaux effets est de rendre possible le développement des sciences humaines ou de la culture. Aux douze contributions primitives, qui traitent de F. Schleiermacher, F. Schlegel, W. von Humboldt, A. Boeckh et de G. Droysen, deux nouveaux textes ont été ajoutés, l’un, en amont, sur Kant, l’autre, en aval, sur W. Dilthey. Denis Thouard a également écrit une postface qui replace l’ensemble des contributions dans le cadre de la discussion actuelle, et fournit ainsi au lecteur la possibilité de s’y orienter. La conviction présidant à cette collection d’études est double : d’une part, qu’il existe bien entre l’herméneutique du xviie siècle et le nouveau paradigme herméneutique une discontinuité fondamentale, d’autre part, que les notions de « méthode » et d’« objectivation », mobilisées par H.-G. Gadamer pour définir mais aussi pour discréditer les ambitions de la nouvelle herméneutique, ne permettent d’en comprendre ni l’histoire, ni les enjeux, ni peut-être et avant tout les ressources.
    Keywords: herméneutique ; Kant ; paradigme ; Dilthey ; Schleiermacher ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 70
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: Energy metabolism is central to life and altered energy expenditure (EE) is often cited as a central mechanism responsible for development of the obese phenotype. Resting EE, EE of physical activity, cold induced thermogenesis and thermic effect of feeding add to produce total EE but can also affect each other. It is thus very important that each component be well measured. Measuring energy expenditure by indirect calorimetry is extremely simple in theory but the practice if far more difficult. Taking into account temperature in small sized animals, measuring accurately the effect of activity on EE, correcting EE for body size body composition, age sex etc… add difficulties in producing reliable data. The goal of this Research Topic was to call for the practical experience of main investigators trained to practice calorimetry in order to get their feedback and the way they deal with the various and specific problems of humans and animal calorimetry. The goal is to share the questions/solutions experienced by the contributors to inititate a “guide of the good practices” that can be periodically updated and used by all those who are and will be interested in measuring energy metabolism from the 20g mouse to the human and large farm animals.
    Keywords: QP1-981 ; Q1-390 ; Body Composition ; Thermogenesis ; brown adipose tissue ; Body Size ; Energy Expenditure ; indirect calorimetry ; physical activity ; metabolic Phenotyping ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 71
    Publication Date: 2023-12-20
    Description: Landscapes have long been viewed as ‘multifunctional’, integrating ecological, economic, sociocultural, historical, and aesthetic dimensions. Landscape science and public awareness in Europe have been progressing in leaps and bounds. The challenges involved in landscape-related issues and fields, however, are multiple and refer to landscape stewardship and protection, as well as to the development of comprehensive theoretical and methodological approaches, in tandem with public sensitization and participatory governance and in coordination with appropriate top-down planning and policy instruments. Landscape-scale approaches are fundamental to the understanding of past and present cultural evolution, and are now considered to be an appropriate spatial framework for the analysis of sustainability. Methods and tools of landscape analysis and intervention have also gone a long way since their early development in Europe and the United States. Although significant progress has been made, there remain many issues which are understudied or not investigated at all—at least in a Mediterranean context. This Special Issue addresses the application of landscape theory and practice in the Eastern Mediterranean and mainly, but not exclusively, reports on the outcomes of an international conference held in Jordan, in December 2015, with the title “Landscapes of Eastern Mediterranean: Challenges, Opportunities, Prospects and Accomplishments”. The focus of this Special Issue, landscapes of the Eastern Mediterranean region, thus constitutes a timely area of research interest, not only because these landscapes have so far been understudied, but also as a rich site of strikingly variegated, long-standing multicultural human–environmental interactions. These interactions, resting on and taking shape through millennia of continuity in tradition, have been striving to adapt to technological advances, while currently juggling with manifold and multilayered socioeconomic and climate–environmental crises.
    Keywords: G1-922 ; Q1-390 ; n/a ; landscape archaeology ; Cyprus ; Landscape Character Assessment (LCA) ; Eastern Mediterranean ; Land Description Units ; stakeholders’ analysis ; UK ; local authority ; ancient sanctuaries ; East Med landscape ; Twain-born Border Lord ; Landscape Decision Support System ; mapping ; topography ; Byzantine landscape and garden art ; economy ; LCA ; classification ; churches ; Arabic-speaking ; participatory ; Landscape Risk Assessment Model ; landforms ; GIS ; planning ; typology ; Greek-speaking ; public realm ; landscape changes ; sacred space ; comparative study ; urban environment ; ideology ; political power ; Arabic landscape and garden art ; cultural sustainability ; historical maps ; religion ; rural land ; multi-functional landscapes ; Lebanon ; Mediterranean ; geographical information system ; spatial distributions ; Land Description Unit (LDU) ; political sustainability ; landscape ; landscape character assessment ; governance ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography
    Language: English
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  • 72
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    Éditions de la Maison des sciences de l’homme
    Publication Date: 2024-04-05
    Description: La publication en 2013 d'une version reconstruite du texte de Kracauer Die totalitäre Propaganda (1937-1938) a renouvelé la perception que l’on pouvait avoir de cette dimension de son œuvre et de son apport à une « théorie critique de la propagande ». La réflexion sur la propagande s’inscrit dans le contexte plus vaste de l’élaboration par les exilés allemands, au tournant des années 1930-1940, d’une grille de lecture du national-socialisme, vu comme une pathologie de la modernité, ainsi que dans celui des grands projets de recherches américains sur la propagande nazie (auxquels Adorno et Kracauer ont été associés). Au sein de la nébuleuse de la « Théorie critique » Kracauer exprime, comme Benjamin, un point de vue à certains égards dissonant. À rebours d’une approche qui insiste surtout sur la continuité entre capitalisme et nazisme, il se montre particulièrement sensible à la séduction esthétique du fascisme, et à sa mise en scène d’une réalité de substitution, qui est selon lui l’expression d’une fuite en avant nihiliste : ses analyses concrètes ne portent pas tant sur les contenus du message que sur le langage même de la propagande, et la vision de la société et de l’histoire qu’elle véhicule, dans sa forme même. Le débat complexe qui se développe à cette époque entre Adorno, Benjamin et Kracauer met notamment en œuvre les catégories de « fétichisme » (Adorno), de « fantasmagorie » et d’« esthétisation du politique » (Benjamin), d’« apparence » et de « pseudo-réalité » (Kracauer). Il présente en premier lieu un intérêt historique, en tant que l’analyse du nazisme constitue pour le projet d’une théorie critique une mise à l’épreuve, qui suscite de vifs débats internes et aboutit chez Adorno et Horkheimer, dans la Dialectique de la raison (1944-1947), à une reformulation de ce projet. Mais dans un contexte aujourd’hui bien différent, les thèmes qui sont débattus entre ces protagonistes, comme celui de la dérive autoritaire du libéralisme, des manipulations de masse, de la construction médiatique du réel n’ont rien perdu de leur actualité.
    Keywords: philosophie ; xxe siècle ; communication ; séduction ésthétique ; histoire des idées ; École de Francfort ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 73
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: In light of the considerable impact of global food supply chains on climate change, more sustainable ways of producing, distributing, and consuming food appear critical for sustainable development. With the aim of contributing to this topic, this Special Issue on sustainable food consumption and food marketing addresses various relevant issues related to food consumption, including innovative and sustainable forms of food production and consumption, animal welfare and meat consumption, price transmission, social media communication, alternative food production, and organic agriculture, among others. As such, this Special Issue sheds light on more sustainable and carbon-friendly food production and consumption systems from various angles. It delivers valuable scientific evidence for the transformation of current carbon-based food supply chains to more eco-friendly, fair, and future-oriented food supply chains.
    Keywords: aquaponics ; Structural Equation Modeling ; consumer behavior ; purchase intention ; willingness to pay ; sustainability ; food market ; veganic ; vegan-organic ; vegan ; stockless ; attitudes ; environmental marketing ; green product ; green consumer ; green purchase decision ; consumer behaviour ; theory of planned behaviour ; sustainable consumption ; Bangladesh ; out-of-home catering ; sustainable nutrition ; variety seeking ; spontaneous choice ; company canteens ; trust ; social media ; small and medium enterprises ; Bresse Gauloise ; choice experiment ; dual-purpose breeds ; faba beans ; Kollbecksmoor ; theory of planned behavior ; Vorwerkhuhn ; White Rock ; green products ; palm oil free ; structural equation modeling ; SEM ; sustainable food consumption ; food waste ; theoretical framework ; food tourism ; community-based tourism ; sustainable development ; community engagement ; rural development ; food heritage ; carbon-friendly food ; emotions ; animal welfare ; cured ham ; discrete choice experiment ; latent construct model ; market instability ; nonlinear empirical dynamics ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 74
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Cognitive building is a pioneering topic envisioning the future of our built environment. The concept of "cognitive" provides a paradigm shift that steps from the static concept of the building as a container of human activities towards the modernist vision of "machine à habiter" of Le Corbusier, where the technological content adds the capability of learning from users' behavior and environmental variables to adapt itself to achieve major goals such as user comfort, energy-saving, flexible functionality, high durability, and good maintainability. The concept is based on digital frameworks and IoT networks towards the concept of a smart city.
    Keywords: explainable post occupancy ; humanoid robot ; lighting simulation software ; BIM ; openBIM ; IFC ; IoT ; sensors ; cognitive buildings ; asset management ; digital twin ; BEM ; simulation modelling ; dynamic simulation ; Building Information Modelling (BIM) ; Internet of Things (IoT) ; facility management ; cyber-physical systems ; Building Management System ; Digital Twin ; Post-Occupancy Evaluations ; cognitive ; digital twins ; building lifecycle management ; artificial intelligence ; decision support ; self-learning ; optimization ; building performance simulation ; lighting simulation ; lighting quality ; visual comfort ; office field study ; evidence-based design ; building information modeling ; HVAC ; fan coil ; Internet of Things ; predictive maintenance ; fault detection ; smart building ; sustainable building ; construction projects ; BIM implementation ; stakeholders ; barriers ; construction product ; servitization ; level of evidence ; level curves ; ground slopes ; embankments ; road and rail design ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 75
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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  • 76
    Publication Date: 2024-04-05
    Description: This is the first of two volumes of the proceedings from the 30th International Wittgenstein Symposium in Kirchberg, August 2007. In addition to several new contributions to Wittgenstein research (by N. Garver, M. Kross, St. Majetschak, K. Neumer, V. Rodych, L. M. Valdés-Villanueva), this volume contains articles with a special focus on digital Wittgenstein research and Wittgenstein's role for the understanding of the digital turn (by L. Bazzocchi, A. Biletzki, J. de Mul, P. Keicher, D. Köhler, K. Mayr, D. G. Stern), as well as discussions - not necessarily from a Wittgensteinian perspective - about issues in the philosophy of information, including computational ontologies (by D. Apollon, G. Chaitin, F. Dretske, L. Floridi, Y. Okamoto, M. Pasin and E. Motta).
    Keywords: B1-5802 ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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  • 77
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    Taylor & Francis | Kierkegaard, Mimesis, and Modernity | Routledge
    Publication Date: 2024-04-08
    Description: “Chapter 6” systematizes and analyzes Kierkegaard’s insightful remarks on human affectivity in relation to moral emotions, body, contagion, and collectivity. Following a brief outline of the conceptualization of affects and human affectivity from Plato, Aristotle, Descartes, Spinoza, Tomkins, and Massumi, the first part zooms in on empathy and sympathy in two important precursors of Kierkegaard, namely David Hume and Adam Smith. The second part argues for Kierkegaard’s distinctively affective reading of admiration, which I locate in its being fundamentally linked with other emotions such as envy, but also in its being oriented toward the mediocre and base, having a limited motivational capacity, and being highly contagious. Affective admiration is then related to the contemporary discussion on moral exemplars, posing a challenge to the view of the epistemological and moral trustworthiness of admiration in moral exemplarity espoused primarily by Linda Zagzebski. The third part centers on the affective character of Kierkegaard’s crowd psychology. Therein I examine his critical remarks on human collectivity, focusing on such key concepts from his social and political philosophy as “crowd” and “the public.” Reading his philosophy alongside two French theorists of mass society, Gabriel Tarde and René Girard, I draw out Kierkegaard’s great interest in such mimetic terms as magnetism, fascination, somnambulism, scapegoating, and violence.
    Keywords: Philosophy, Kierkegaard, 19th century philosophy, history of philosophy, aesthetics, religion and philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPC History of Western philosophy::HPCF Western philosophy, from c 1900 - ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general::HRAB Philosophy of religion ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHR Western philosophy from c 1800 ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAB Philosophy of religion
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  • 78
    Publication Date: 2024-04-05
    Description: Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases.
    Keywords: QH426-470 ; Q1-390 ; DNA Repair ; Aging ; helicases ; Telomere ; Cancer ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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  • 79
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: The practical importance of economic valuation information can hardly be overstated. Coastal and marine resource policy planning and management benefit from complete information on the impact of policy decisions.
    Keywords: Q1-390 ; internet survey ; open access ; contingent valuation method ; coastal management ; tourism ; Thailand ; marine ; wetlands ; harmful algae blooms ; environmental valuation ; quota ; cyanobacteria ; estuarine and coastal ecosystems ; wealth accounting ; seawater quality ; economic analysis ; remote sensing ; ecosystem restoration ; coastal ecosystems ; random utility model ; contingent behavior ; public policy ; habitat–fishery linkages ; Barbados ; coastal ecosystem services valuation ; fishery ; mangroves ; ecosystem services valuation ; coral reefs valuation ; recreational boating ; regulated open access ; non-market value ; economic valuation ; ecosystem services ; coastal ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
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  • 80
    Publication Date: 2024-03-27
    Description: This reprint focuses on exploring the relationship between urban form, mobility, and social well-being across neighborhoods, cities, and regions. Understanding more about these relationships is helpful in shaping integrated sustainable urban planning and transport development strategies. All reprint chapters primarily contribute to the existing literature on the interdisciplinary field of the impact of urban planning and transport on social well-being and facilitate novel ways of measuring the abstract concept of well-being, particularly in Asian and European countries. We suggested that further research could explore these themes in greater depth by means of both theoretical frameworks and methodological developments in this integrated field.
    Keywords: social well-being ; social equity ; quality of life ; behavioural change and decision making ; urban mobility ; travel behaviour ; sustainable transport development ; urban and transport modelling ; urban form ; urban planning ; sustainable cities ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 81
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.
    Keywords: QH301-705.5 ; Q1-390 ; STRIPAK ; skin cancer ; n/a ; Lats2 ; transcription ; myofibroblast ; epigenetic ; Hippo ; cancer immunity ; TAZ ; Taz ; TAZ (transcriptional co-activator with PDZ-binding motif) ; adaptive immunity ; fibroblasts ; innate immunity ; LATS ; MST (mammalian STE20-like protein kinase) ; phosphorylation ; stem cells ; wound healing ; signal transduction ; angiogenesis ; LATS1/2 ; EMT ; protein-protein interactions ; structure biology ; Hippo pathway ; hippo pathway ; autoimmunity ; Mps one binder ; YAP/TAZ ; GPCR ; fibrosis ; MST1/2 ; YAP (yes-associated protein) ; YAP ; Yap ; protein kinase ; LATS (large tumor suppressor kinase) ; peripheral nerve sheath tumor ; signal cross-talk ; stem cell ; skin development ; STK38 ; tumorigenesis ; NDR ; schwannoma ; G protein-coupled receptor ; anti-cancer therapy ; feedback loops ; vascular mimicry ; castration resistance ; chromatin ; Hippo signalling ; ECM ; MST ; prostate cancer ; TEAD ; cancer ; zebrafish ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 82
    Publication Date: 2024-03-29
    Description: The visual system consists of hierarchically organized distinct anatomical areas functionally specialized for processing different aspects of a visual object (Felleman & Van Essen, 1991). These visual areas are interconnected through ascending feedforward projections, descending feedback projections, and projections from neural structures at the same hierarchical level (Lamme et al., 1998). Accumulating evidence from anatomical, functional and theoretical studies suggests that these three projections play fundamentally different roles in perception. However, their distinct functional roles in visual processing are still subject to debate (Lamme & Roelfsema, 2000). The focus of this Research Topic is the roles of feedforward and feedback projections in vision. Even though the notions of feedforward, feedback, and reentrant processing are widely accepted, it has been found difficult to distinguish their individual roles on the basis of a single criterion. We welcome empirical contributions, theoretical contributions and reviews that fit into any one (or a combination) of the following domains: 1) their functional roles for perception of specific features of a visual object 2) their contributions to the distinct modes of visual processing (e.g., pre-attentive vs. attentive, conscious vs. unconscious) 3) recent techniques/methodologies to identify distinct functional roles of feedforward and feedback projections and corresponding neural signatures. We believe that the current Research Topic will not only provide recent information about feedforward/feedback processes in vision but also contribute to the understanding fundamental principles of cortical processing in general.
    Keywords: BF1-990 ; Q1-390 ; projections ; processes ; Feedback ; Vision ; feedforward ; Visual System ; mechanisms ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 83
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    Taylor & Francis
    Publication Date: 2024-04-07
    Description: Analyzing features of Wittgenstein's philosophical work and including in-depth textual analyses, this study investigates the impact of Ludwig Wittgenstein's work on contemporary German and French novelists. Drawing upon aesthetics, architectural history, philosophy of science, and photography, the book seeks to explain why references both to Wittgenstein as a person, as well as to his work are more pervasive than other equally renowned twentieth century philosophers and asks why some authors such as Händler and Roubaud, are less well-known and only partially translated into Eng.
    Keywords: sebalds ; narratives ; wenn ; wir ; jacques ; roubaud ; text ; wittgensteins ; reflections ; warburg ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought
    Language: English
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  • 84
    Publication Date: 2024-04-05
    Description: The eBook "Building Strategies for Porcine Cancer Models" presents a series of articles demonstrating the state-of-the-art developments in pig models for cancer research. Renowned researchers dedicated to the reproduction, genomic and biological engineering of the pig model for biomedicine contribute to this special research area. Although advances in these areas are occurring at surprising speeds, they are still far from realizing all the potential benefits that this biological model could provide to science. The current biomedical models may limit the frontier of knowledge in the cancer research.
    Keywords: QH426-470 ; Q1-390 ; Pigs ; Cloning ; Genetic engineering ; Comparative Genomics ; Gene Editing ; Animal Models ; Cancer ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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  • 85
    Publication Date: 2024-04-05
    Description: This e-book summarizes recent advances in the young and rapidly developing field of microbial volatiles. Articles included here reveal novel information about the chemical diversity of bacterial and fungal volatiles, their functions, their roles in inter-specific and inter-kingdom interactions and the metabolic and physiological changes their exposure causes in the target organisms. The e-book is divided in three chapters: (1) Natural Functions of Microbial Volatiles; (2) Volatile Production and Ecosystem Functioning and (3) Volatile Detection and Identification.
    Keywords: QR1-502 ; Q1-390 ; microorganisms ; infochemicals ; natural functions ; induced systemic resistance ; Plants ; antimicrobials ; plant growth promotion ; volatiles ; interactions ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Phytochemicals from natural products are now widely used as food additives (antioxidants, pigments), food supplements, cosmetic ingredients, etc. Currently, the majority of the extraction processes implemented on an industrial scale for the production of bioactive-enriched extracts are based on solvents of petroleum origin. However, contemporary trends in green extraction techniques dictate a minimization of solvent use, low-energy processes and novel eco-friendly materials that are environmentally benign. The search for liquids and/or extraction technologies that could meet such requirements is, therefore, an intriguing concept. This book addresses the concept of recovering natural bioactive substances from plant resources, using state-of-the-art extraction technologies, with prospects in the food, cosmetic and pharmaceutical industries.
    Keywords: cosmeceutical product ; long-lived trees ; simplex-centroid mixture design ; deep eutectic solvents ; bioactivity ; flavonoids ; extraction ; deep eutectic solvents (DES) ; natural deep eutectic solvents (NaDES) ; Moringa oleifera ; polyphenols ; ultrasonication pretreatment ; antioxidants ; hydroxypropyl β-cyclodextrin ; potato peels ; grape seed ; grape skin ; green extraction ; antioxidant activity ; chlorogenic acid ; caffeine ; β-cyclodextrin ; coffee pulp ; sensory analysis ; cold brew ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 87
    Publication Date: 2024-04-05
    Description: Planting trees in the agricultural landscape, in the form of establishing agroforestry systems, has a significant role to play in potentially improving ecosystem services, such as increased biodiversity, reduced soil erosion, increased soil carbon storage, improved food security and nutrition, and reduced greenhouse gas emissions. While the role of trees in agroforestry systems in improving ecosystem services has been researched, studies in new systems/regions and new agroforestry system designs are still emerging. This Special Issue includes selected papers presented at the 4th World Congress on Agroforestry, Montpellier, France 20–22 May 2019, and other volunteer papers. The scope of articles includes all aspects of agroforestry systems.
    Keywords: QH301-705.5 ; Q1-390 ; S1-972 ; farmers’ knowledge ; ahannon-wiener index ; economic benefits ; alley cropping ; lignin ; shelterbelts ; agroforestry ; natural capital ; forest farming ; nutrient content ; agroforestry system ; review ; Amazonia ; cropland ; riparian buffers ; climate change ; subtropical acidic forest soil ; bees ; phosphorus ; pollination ; 15N tracing experiment ; stable isotope ; West Java ; interspecific competition ; growth form ; cropping system ; climate change mitigation ; gross N transformation rates ; East Africa ; improved-fallow ; N-fixing trees ; carbon sequestration ; home garden ; margalef index ; windbreaks ; leaf nutrient diagnosis ; agroforestry systems ; pollinators ; sorption ; forestland ; China ; temperature change ; fractionation ; hedgerows ; native trees ; slash-and-mulch ; soil N ; shade tree species ; soil C ; Alpinia oxyphylla ; sustainable management ; plant water use ; rubber-based agroforestry system ; ecosystem services ; Indonesia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 88
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    University of Hawai'i Press
    Publication Date: 2024-03-26
    Description: From Sung times, and throughout the Ming period, one of the dominant philosophies of China had been a dualistic rationalism thought to be firmly grounded on the classics. Tai Chen (1723-1777) was a scholar and philosopher during the Ch'ing period- a time when China produced few philosophic thinkers. He was the greatest of these, and his views are embodied chiefly in Yuan Shan and in Meng Tzu txu-yi shu-cheng. In place of the prevailing Sung dualism, Tai Chen propounded a rationalistic monism seldom before insinuated in a Chinese philosophy. He declines to accept current dogmas and preferred to seek his own truths. His commentaries opposed the time-honored interpretations of Chu Hsi, and he discredited them on purely philosophical grounds. But with few disciples to carry on his teachings, he was virtually forgotten or ignored in China for more than a hundred years after his death. It was not until early in the present century- with China under the pressures of Western aggression and internal disorders-that Tai Chen's nearness to Western thought was rediscovered and his important role in the history of philosophy recognized. Curiously, this first of China's Western-oriented philosophers even today remains little known in the West and his major writings largely untranslated.
    Keywords: Philosophy ; History ; thema EDItEUR::D Biography, Literature and Literary studies::DN Biography and non-fiction prose::DNB Biography: general ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHC East Asian and Indian philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 89
    Publication Date: 2023-12-20
    Description: In this eBook, Conceptual Categories and the Structure of Reality, the title very well describes the book's content. Within the book's pages a selection of academics from a variety of human behaviour, human/social science and humanities disciplines write about their research all of which can be typified by their consideration of how categories are used to structure understanding of phenomena. These authors have considered how reality may be understood through notions such as categorial and structural ontologies, part-whole relatoinships (mereology), the qualitative, quantitative and philosophical use of the facet theory approach to research, mapping sentences and declarative mapping sentence, hermeneutics, concepts and constructs, similarities and differences. The resulting collection presents the foregoing conceptual and empirical approaches to knowledge development in general (chapter 1&3 Hackett); Phillips and Wislons' review of compositional syntax in bird calls (chapter 2); neurobehavioral decision systems (chapter 4 Foxall); representations of human psychological processes (chapter 5 Juan-Miguel López-Gil; Rosa Gil; Roberto García); free associations mirroring and its relation to self- and world-related concepts (chapter 6 Martin Kuška; Radek Trnka; Aleš Antonín Kuběna; Jiří Růžička); local knowledge and going beyond the data (chapter 7 Steven Phillips); categorical etiologies of speech sound disorders (chapter 8 Kelly Farquharson); similarity of visual appearance (chapter 9 Nao Nakatsuji; Hisayasu Ihara; Takeharu Seno; Hiroshi Ito); and a consideration of the seminal writing of David Oderberg's on the categorial classification of reality (chapter 10 Hackett).
    Keywords: BF1-990 ; Q1-390 ; mereology ; similarities ; hermeneutics ; concepts ; category ; ontology ; facet theory ; declarative mapping sentence ; bic Book Industry Communication::J Society & social sciences::JM Psychology
    Language: English
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  • 90
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This reprint is devoted to studying RE-doped bulk and nanocrystalline materials from a scientific point of view and to presenting their possible applications in any field. This reprint is intended to serve as a unique multidisciplinary forum covering all aspects of science, technology and applications of rare-earth-doped crystals, starting from the growth techniques with specific attention to the optical and spectroscopic properties of these materials and their applications.
    Keywords: luminescence thermometry ; phosphors ; Er3+ ; Judd–Ofelt ; Slater integrals ; anisotropy ; particle synthesis ; luminescence ; europium-doping ; Lu(OH)2Cl ; Lu2O3 ; europium luminescence ; charge compensation ; niobium ; microwave synthesis ; hafnia ; dispersion ; photoluminescence ; co-precipitation ; anti-counterfeiting ; CaWO4 ; nanoparticles ; in situ TEM ; ion irradiation ; thermal annealing ; ceria ; rare-earth orthochromites ; magnetization reversal ; magnetocaloric effect ; phosphor ; Eu3+ ; niobates ; Judd-Ofelt ; quantum efficiency ; refractive index ; microwave heating ; cerium oxide ; temperature field ; morphology ; SrWO4 ; fingerprint ; K0.3Bi0.7F2.4 ; nanophosphors ; lanthanide ; infrared spectroscopy ; Nd-luminescence ; yttria-stabilized zirconia ; Tb4O7-doped ; annealed in H2/Ar atmosphere ; optical properties ; optical floating-zone method ; saturation spectroscopy ; LYB ; ytterbium ; erbium ; spectral hole ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 91
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: This volume provides information and analyses to better grasp the social implications of geographical borders as well as the individuals who travel between them and those who live in border regions. Sociologists, anthropologists, philosophers, linguists, and scholars of international relations and public health are just some of the authors contributing to Rethinking Borders. The diversity in the authors’ disciplines and the topics they focus on exemplify the intricacies of borders and their manifold effects. This openness to so many schools of thought stands in contrast to the solidification of stricter borders across the globe. The contributions range from case studies of migrants’ sense of belonging and safety to theoretical discussions about migration and globalization, from empirical studies about immigrant practices and exclusionary laws to ethical concerns about the benefits of inclusion. It is timely that this collective work is published in the middle of a pandemic that has affected every single part of the world. Unprecedented border closures and stringent travel restrictions have not been enough to contain the virus entirely. As COVID-19 shows, diseases, ideas, and xenophobic and racist discourses know no borders. Plans that transcend borders are vital when dealing with global threats, such as climate change and pandemics.
    Keywords: distributive justice ; political legitimacy ; international legitimacy ; liberal theory of international relations ; immigration ; political self-determination ; territorial rights ; nationalism ; statism ; migration crisis ; ideal type ; refugees ; immigrants ; migration policy ; methodological nationalism ; nation-state ; state/anarchy model ; globalization ; epistemic ideals ; human mobility ; citizenship ; children in detention ; border policing ; illegalization ; neoliberalism ; USA ; Australia ; immigration detention ; care ; migration ; migration management ; nursing ; recruitment ; globalized labor markets ; Germany ; migration and crime ; human security ; border wall ; safest American city ; Latinos ; decolonisation ; SADC borders ; regional integration ; diversity ; superdiversity ; multiculture ; critical diversity studies ; racism ; discrimination ; diversity policies ; English name ; Chinese name ; Taiwan ; pragmalinguistics ; sociolinguistics ; naming practices ; identity ; nickname ; anti-immigration ; populism ; xenophobia ; globalists ; borders ; global health diplomacy (GHD) ; CARICOM ; public health ; health security ; epidemics ; Coronavirus 2019 (COVID-19) ; non-communicable diseases (NCDs) ; peace ; foreign policy ; Caribbean ; border ; homelessness ; hard drug users ; self-inflicted violence ; body without organs ; group asylum ; sovereignty ; ethics of recognition ; ethics of care ; solidarity ; Axel Honneth ; Jürgen Habermas ; mental health ; point in time ; diagnosis ; border walls ; fences ; limited migration ; open borders ; free movement ; regionalism ; localism ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 92
    Publication Date: 2024-03-29
    Description: Foreword by Richard J. Stevenson, Macquarie University (Australia): It was long thought that the human nose might be able to discriminate somewhere in the order of 10,000 different odourants. The recent finding that the human nose can discriminate something like a trillion different smells serves as yet another reminder that we have again underestimated the capacity of our sense of smell (Bushdid, Magnasco, Vosshall & Keller, 2014). This volume serves as a further corrective for anyone who should hold the view that olfaction is unimportant in human affairs. The papers presented in this ebook, carefully collated and overseen by Aldo Zucco, Benoist Schaal, Mats Olsson and Ilona Croy, showcase a large number of quite different reasons for studying the applied side of olfaction, and indeed human olfaction in general. The 23 contributions presented here cover a broad range of topics, which illustrate contemporary interests in our field. Although with a strong applied focus, a noteworthy feature of this ebook is the richness of the theoretical perspectives that are developed. These range from considerations of olfactory perception, memory, expertise, and priming right the way through to receptor genetics. These contributions, from many leading experts in the field, will surely shape much of the applied work linking olfaction to disease, which is a further focus of this ebook. In respect to health and disease, the chapters on aging, pregnancy, depression, alcohol dependency and environmental odours, present overviews and rich new data on many contemporary problems, to which the study of olfaction is now contributing. A particularly notable aspect of olfactory experience is the affective impact that odours can have on people and their lives. The ebook covers some particularly intriguing aspects of work in this area, with empirical studies investigating dissociations between wanting and liking, stress reduction in the elderly, mother-infant bonding, and the emotions that different odourants can evoke. This affective line of work is nicely complemented by empirical studies on expertise, the effect of odours on visual attention, and the relationship between particular personality traits and interest in olfaction. The gradual appropriation of methods from cognitive neuroscience into olfaction is also nicely represented in this ebook, with at least three of the chapters reporting data using neuroimaging, including a particular intriguing study looking at recognition of odours in mixtures. Finally, the close links between olfactory perception and sensory evaluation are also reflected in a chapter on wine. I hope that readers of this e-book will be struck, as I have been in reading its various chapters, how much olfaction affects our lives, and how the study of this sense can enrich it.
    Keywords: BF1-990 ; Q1-390 ; Disease ; Health ; Everyday Life ; Cognition ; Applied olfaction ; Expertise ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The intention of this Special Issue is to focus on new aspects of drug discovery, including the search for new molecular targets of various diseases, the creation of new modern methods for diagnosing diseases, the development of new test systems and kits for assessing the selectivity and effectiveness of new drugs, the study of the molecular mechanisms of biologically active compounds, the formulation of new drugs, pharmacokinetic and pharmacodynamic studies, and preclinical trials of important molecules.
    Keywords: Streptococci ; antimicrobials ; QSAR ; MD simulation ; Kunitz-type peptides ; neuroprotective activity ; sea anemones ; TRPV1 ; P2X7R ; Parkinson’s disease (PD) ; diffuse large B cell lymphoma (DLBCL) ; deep neural network ; drug discovery ; drug combination ; biomarker ; cancer severity ; cancer prognosis ; MAFB ; tumor-associated macrophages ; prostate cancer ; photodynamic therapy ; magnetic resonance imaging ; ex vivo ; anti-inflammatory substance ; N-acylhydrazone ; naphthyl-N-acylhydrazone ; LASSBio-1524 analogues ; phosphacoumarin ; azomethine ylide ; cycloaddition ; anti-cancer ; cytotoxicity ; quantum chemistry ; pravastatin ; metformin ; radiation-induced intestinal injury ; minipigs ; epithelial regeneration ; inflammation ; arylazo sulfones ; DNA binding ; DNA cleavage ; DNA photocleavage ; A375 melanoma cells ; molecular docking ; radicals ; N–S bond homolysis ; platinum(II) ; five-coordinate complexes ; glycoconjugation ; cytotoxic activity ; protein X-ray structure ; lipophilicity ; natural products ; acetylcholinesterase inhibitors ; butyrylcholinesterase inhibitors ; Alzheimer’s disease ; central nervous system ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-01-31
    Description: This edition is a reprint of the Special Issue published online in the open access journal Remote Sensing (ISSN 2072-4292) from 2016–2017 (available at: http://www.mdpi.com/journal/remotesensing/special issues/rsALS), complemented by selected articles published in Remote Sensing
    Keywords: G1-922 ; Q1-390 ; Airborne Lidar Systems ; Data Processing
    Language: English
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  • 95
    Publication Date: 2024-04-05
    Description: Women drinking during pregnancy can result in Fetal Alcohol Spectrum Disorder (FASD), which may feature variable neurodevelopmental deficits, facial dysmorphology, growth retardation, and learning disabilities. Research suggests the human brain is precisely formed through an intrinsic, genetic-cellular expression that is carefully orchestrated by an epigenetic program. This program can be influenced by environmental inputs such as alcohol. Current research suggests the genetic and epigenetic elements of FASD are heavily intertwined and highly dependent on one another. As such, now is the time for investigators to combine genetic, genomic and epigenetic components of alcohol research into a centralized, accessible platform for discussion. Genetic analyses inform gene sets which may be vulnerable to alcohol exposure during early neurulation. Prenatal alcohol exposure indeed alters expression of gene subsets, including genes involved in neural specification, hematopoiesis, methylation, chromatin remodeling, histone variants, eye and heart development. Recently, quantitative genomic mapping has revealed loci (QTLs) that mediate alcohol-induced phenotypes identified between two alcohol-drinking mouse strains. One question to consider is (besides the role of dose and stage of alcohol exposure) why only 5% of drinking women deliver newborns diagnosed with FAS (Fetal Alcohol Syndrome)? Studies are ongoing to answer this question by characterizing genome-wide expression, allele-specific expression (ASE), gene polymorphisms (SNPs) and maternal genetic factors that influence alcohol vulnerability. Alcohol exposure during pregnancy, which can lead to FASD, has been used as a model to resolve the epigenetic pathway between environment and phenotype. Epigenetic mechanisms modify genetic outputs through alteration of 3D chromatin structure and accessibility of transcriptional machinery. Several laboratories have reported altered epigenetics, including DNA methylation and histone modification, in multiple models of FASD. During development DNA methylation is dynamic yet orchestrated in a precise spatiotemporal manner during neurulation and coincidental with neural differentiation. Alcohol can directly influence epigenetics through alterations of the methionine pathway and subsequent DNA or histone methylation/acetylation. Alcohol also alters noncoding RNA including miRNA and transposable elements (TEs). Evidence suggests that miRNA expression may mediate ethanol teratology, and TEs may be affected by alcohol through the alteration of DNA methylation at its regulatory region. In this manner, the epigenetic and genetic components of FASD are revealing themselves to be mechanistically intertwined. Can alcohol-induced epigenomic alterations be passed across generations? Early epidemiological studies have revealed infants with FASD-like features in the absence of maternal alcohol, where the fathers were alcoholics. Novel mechanisms for alcohol-induced phenotypes include altered sperm DNA methylation, hypomethylated paternal allele and heritable epimutations. These studies predict the heritability of alcohol-induced epigenetic abnormalities and gene functionality across generations. We opened a forum to researchers and investigators the field of FASD to discuss their insights, hypotheses, fresh data, past research, and future research themes embedded in this rising field of the genetics and epigenetics of FASD. This eBook is a product of the collective sharing and debate among researchers who have contributed or reviewed each subject.
    Keywords: QH426-470 ; QH301-705.5 ; Q1-390 ; DNA Methylation ; Fetal Alcohol Syndrome ; histone modification ; Epigenetic medicine ; Genomics ; Alcoholism ; transgenerational ; Pregnancy drinking ; FASD ; Gene environmental interaction ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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  • 96
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    EuroPhilosophie Éditions
    Publication Date: 2024-04-05
    Keywords: B1-5802 ; johannisme ; politique ; état ; éducation ; religion ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 97
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: In this book are reported nine works related to land subsidence monitoring using remote sensing techniques. Land subsidence is a common phenomenon in many regions of the world, where it causes degradation of local ecosystems and disruption of economic activities. Its effects are more evident in densely populated areas in particular in low-lying territories such as river deltas and coastal areas where the combination of land subsidence and sea level rise increases the flooding risk. For this reason, the monitoring of ground deformations is a crucial step to obtain important information for the development of risk mitigation strategies. In the presented papers, the characteristics of land subsidence occurring in different study areas are described, and recent developments in the used methodologies for the monitoring of the ground displacements are discussed and validated also by means of ground-based data. Moreover, advantages and disadvantages of the adopted techniques are highlighted. The outcomes of these research works can provide national and local authorities with useful information for the implementation of integrated monitoring systems in the areas most affected by land subsidence.
    Keywords: land subsidence ; IPTA ; land-use ; water resource utilization ; groundwater change ; deformation ; geology ; Gävle ; InSAR ; PSI ; precise levelling ; sentinel-1 ; subsidence ; Sweden ; ALOS/PALSAR ; time series analysis ; SBAS ; hot spring water ; hydrothermal fluids ; Hakone Volcano ; satellite geodesy ; radar interferometry ; persistent scatterers ; distributed scatterers ; orbit combination ; Sentinel-1 ; cavern field ; salt deposit ; geophysical modeling ; underground gas storage ; GNSS ; ground movement ; subsidence monitoring ; integrated numerical simulation ; Dubrovnik ; satellite altimetry ; tide gauges ; vertical land motion ; DInSAR ; mining-induced tremors ; land surface deformation ; Upper Silesian Coal Basin ; Interferometry ; SNAP-StaMPS ; Ground deformation ; Po River Delta ; integrated monitoring ; time-series analysis ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 98
    Publication Date: 2024-04-05
    Description: The brain of each animal shows specific traits that reflect its phylogenetic history and its particular lifestyle. Therefore, comparing brains is not just a mere intellectual exercise, but it helps understanding how the brain allows adaptive behavioural strategies to face an ever-changing world and how this complex organ has evolved during phylogeny, giving rise to complex mental processes in humans and other animals. These questions attracted scientists since the times of Santiago Ramon y Cajal one of the founders of comparative neurobiology. In the last decade, this discipline has undergone a true revolution due to the analysis of expression patterns of morphogenetic genes in embryos of different animals. The papers of this e-book are good examples of modern comparative neurobiology, which mainly focuses on the following four Grand Questions: a) How are different brains built during ontogeny? b) What is the anatomical organization of mature brains and how can they be compared? c) How do brains work to accomplish their function of ensuring survival and, ultimately, reproductive success? d) How have brains evolved during phylogeny? The title of this e-book, Adaptive Function and Brain Evolution, stresses the importance of comparative studies to understand brain function and, the reverse, of considering brain function to properly understand brain evolution. These issues should be taken into account when using animals in the research of mental function and dysfunction, and are fundamental to understand the origins of the human mind.
    Keywords: RC321-571 ; Q1-390 ; comparative neurobiology ; brain evolution ; phylogeny ; ontogeny ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 99
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: Satellite Earth observation (EO) data have already exceeded the petabyte scale and are increasingly freely and openly available from different data providers. This poses a number of issues in terms of volume (e.g., data volumes have increased 10
    Keywords: G1-922 ; Q1-390 ; knowledge base ; metadata ; Synthetic Aperture Radar ; versioning ; web services ; web application ; sustainable development goals ; earth observations ; FAIR principles ; land cover classification ; semantic enrichment ; satellite imagery ; imagery ; analysis ; information extraction ; ARD ; analysis ready data ; swiss DC ; data cube ; Open Data Cube ; UN 2030 Agenda for Sustainable Development ; time-series ; graph data ; Digital Earth Australia ; query store ; open data cube ; pyroSAR ; R ; earth oberservation ; image cube ; sentinel ; open science ; Sentinel ; reproducibility ; change ; big EO data ; earth observation ; big Earth data ; Earth Observations ; Australia ; geospatial standards ; big earth data ; visualization ; UN System of Environmental Economic Accounting ; interferometric coherence ; dynamic data citation ; intelligent semantic agents ; data curation ; snow cover ; big data ; Analysis Ready Data ; climate change ; topology based map algebra ; data provenance ; Sentinel-1 ; Sentinel-2 ; remote sensing ; interoperability ; image data cube ; optical remote sensing ; dual-polarimetric decomposition ; GIS ; Gran Paradiso National Park ; data sharing ; SAR ; map algebra ; Earth observation ; Armenian DC ; data cubes ; Data Cube ; data discovery ; Earth observation data ; persistent identifier ; Landsat ; GRASS GIS ; subset ; landsat ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography
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  • 100
    Publication Date: 2024-04-05
    Description: The advent of next-generation sequencing technologies has resulted in a remarkable increase our understanding of human and animal neurological disorders through the identification of disease causing or protective sequence variants. However, in many cases, robust disease models are required to understand how changes at the DNA, RNA or protein level affect neuronal and synaptic function, or key signalling pathways. In turn, these models may enable understanding of key disease processes and the identification of new targets for the medicines of the future. This e-book contains original research papers and reviews that highlight either the impact of next-generation sequencing in the understanding of neurological disorders, or utilise molecular, cellular, and whole-organism models to validate disease-causing or protective sequence variants.
    Keywords: RC321-571 ; Q1-390 ; Stem Cells ; glycine receptor ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; PET imaging ; LRRK2 ; Zebrafish ; Inflammation ; GABA-A receptor ; NMDA receptors ; Intellectual Disability ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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