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  • bic Book Industry Communication::M Medicine  (1,154)
  • bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues  (828)
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  • 101
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The need for electromechanical energy conversion that takes place in electric motors, generators, and actuators is an important aspect associated with current development. The efficiency and effectiveness of the conversion process depends on both the design of the devices and the materials used in those devices. In this context, this book addresses important aspects of electrical machines, namely their materials, design, and optimization. It is essential for the design process of electrical machines to be carried out through extensive numerical field computations. Thus, the reprint also focuses on the accuracy of these computations, as well as the quality of the material models that are adopted. Another aspect of interest is the modeling of properties such as hysteresis, alternating and rotating losses and demagnetization. In addition, the characterization of materials and their dependence on mechanical quantities such as stresses and temperature are also considered. The reprint also addresses another aspect that needs to be considered for the development of the optimal global system in some applications, which is the case of drives that are associated with electrical machines.
    Keywords: switched reluctance motor drive ; model predictive control ; continuous control set ; pulse-width modulation ; magnetization surface ; electrical drive ; magnetic permeability ; effective parameters ; induction motor ; finite element method ; linear electric actuators ; linear switched reluctance actuators ; permanent magnets ; linear hybrid reluctance actuators ; machine design ; finite element analysis ; detent force reduction ; flux switching ; performance comparison ; torque density ; permanent magnet (PM) ; eddy current loss ; heat generation ; magnetic circuit ; magnetic composite material ; spatial harmonics ; concentrated winding motor ; additive manufacturing ; convolution ; infinite impulse response (IIR) filters ; additive white noise ; DC drift ; magnetic flux density ; magnetic hysteresis ; kernel ; magnetic materials ; soft magnetic materials ; selective laser melting ; iron losses ; magnetic properties ; transformer ; induction motors ; surrogate optimization ; Box–Behnken design ; Latin-hypercube sampling ; clustering ; particle swarm optimization ; pattern search ; SRM ; PV panels ; water pumping system ; multilevel converter ; fault-tolerant ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 102
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The researchers involved in this reprint will continue their studies to improve the existent dental biomaterials in order to achieve optimal dental treatment with biocompatible, bioactive, and stable properties. As the Guest Editors, we sincerely value and thank the reviewers for their insightful comments and the support of the team at Bioengineering. Finally, we express our gratitude to all contributing authors for their valuable research. Altogether, the 16 research papers/reviews in this Special Issue entitled "Recent Advances in Biomaterials and Dental Disease" reflect the importance of in vitro and in vivo studies for improving the efficacy of using biomaterials in dental treatment.
    Keywords: adhesion ; bonding ; dental porcelain ; glass ceramics ; orthodontic bracket ; shear strength ; aligner ; cytotoxicity ; estrogenicity ; invisalign ; monomer ; retainer ; 3D resin ; endodontic sealer ; polyphenols ; resveratrol ; pyrogallol ; biological activity ; piezoelectric surgery ; endodonticsurgery ; crack formation ; ultrasonic tip ; retropreparation ; antibacterial effect ; dental impressions ; disinfectant agents ; disinfection ; oral bacteria ; implant periapical lesion ; implant failure ; peri-implantitis ; endodontic surgery ; complication ; retreatment procedure ; filling materials removal ; revision system ; sonic activation ; oval-shaped canal ; decontamination ; lithium disilicate ; resin ; saliva ; shear bond strength ; crowns ; fixed prosthodontics ; resin composite ; survival ; bond strength ; contact angle ; dentin ; desensitizers ; resin cements ; 3D printing ; digital light processing ; interim crown ; in vivo study ; wear ; endodontists ; general practicing dentists ; root canal treatment ; quality ; undergraduate students ; traumatic dental injury ; tooth fracture ; adhesive reattachment ; pulp ; regeneration ; revitalization ; transplant ; root ; maxillary premolars ; upper premolars ; canal ; root canal anomalies ; anatomical variations ; root morphology ; coneless ; MEA technique ; n/a ; bic Book Industry Communication::M Medicine
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  • 103
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: This reprint focuses on recent advances in the clinical care of patients with acute and chronic coronary syndromes. We must accumulate novel scientific and clinical knowledge in this field to develop seamless treatments and preventive strategies for this patient population. Furthermore, accumulated data have implicated that there are some residual risk factors for coronary syndromes, and the clinical management of cardiovascular/non-cardiovascular complications associated with coronary syndromes is also a critical concern. We hope that this reprint will facilitate the management of future patients with coronary syndromes; however, further research is still required. It is also our hope that this reprint will promote future research to enable a better understanding of the clinical practice of coronary syndromes.
    Keywords: statin ; myocardial infarction ; renal function ; coronary CT angiography ; subtraction ; fractional flow reserve ; coronary artery disease ; Agatston score ; uric acid ; endothelial function ; ischemic heart disease ; ischemia with no obstructive coronary artery disease ; angioplasty ; drug-eluting stents ; non-ST-elevation myocardial infarction ; multivessel disease ; acute coronary syndrome ; chronic coronary syndrome ; xanthine oxidoreductase ; coronary artery spasm ; gender differences ; vasospastic angina ; microvascular spasm ; microvascular vasodilatory function ; high coronary thrombus burden ; tissue plasminogen activator ; catheter-directed thrombolysis ; olmesartan ; amlodipine ; rosuvastatin ; single pill combination ; phase III clinical trial ; computed tomography ; computed tomography perfusion ; myocardial perfusion abnormality ; aspirin ; clopidogrel ; prasugrel ; P2Y12 inhibitor ; bleeding ; nitrate ; vasodilator ; biomarker ; mortality ; risk-score model ; n/a ; NGAL ; contrast-induced acute kidney injury ; percutaneous coronary intervention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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  • 104
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint focuses on the application of the combination of synthetic aperture radars and depth learning technology. It aims to further promote the development of SAR image intelligent interpretation technology. A synthetic aperture radar (SAR) is an important active microwave imaging sensor, whose all-day and all-weather working capacity give it an important place in the remote sensing community. Since the United States launched the first SAR satellite, SAR has received much attention in the remote sensing community, e.g., in geological exploration, topographic mapping, disaster forecast, and traffic monitoring. It is valuable and meaningful, therefore, to study SAR-based remote sensing applications. In recent years, deep learning represented by convolution neural networks has promoted significant progress in the computer vision community, e.g., in face recognition, the driverless field and Internet of things (IoT). Deep learning can enable computational models with multiple processing layers to learn data representations with multiple-level abstractions. This can greatly improve the performance of various applications. This reprint provides a platform for researchers to handle the above significant challenges and present their innovative and cutting-edge research results when applying deep learning to SAR in various manuscript types, e.g., articles, letters, reviews and technical reports.
    Keywords: heterogeneous transformation ; SAR image ; optical image ; conditional generative adversarial nets (CGANs) ; self-supervised ; synthetic aperture radar (SAR) ; despeckling ; enhanced U-Net ; video synthetic aperture radar (Video-SAR) ; moving target tracking ; guided anchor Siamese network (GASN) ; interferometric synthetic aperture radar ; deep convolutional neural network ; phase unwrapping ; unsupervised change detection ; polarimetric synthetic aperture radar (PolSAR) ; UAVSAR ; multi-scale shallow block ; multi-scale residual block ; synthetic aperture radar ; image registration ; transformer ; deep learning ; SAR target detection ; multiscale learning ; ship detection ; SAR ship detection ; position-enhanced attention ; lightweight backbone ; image augmentation ; building extraction ; SAR ; semantic segmentation ; SAR dataset ; single-stage detector ; two-stage detector ; anchor free ; train from scratch ; oriented bounding box ; multi-scale detection ; computer vision ; low-grade road extraction ; remote sensing ; image segmentation ; optical images ; scene classification ; on-board ; lightweight self-supervised algorithm ; synthetic aperture radar (SAR) image ; arbitrary-oriented ship detection ; differentiable rotational IoU algorithm ; triangle distance IoU loss ; attention-weighted feature pyramid network ; multiple skip-scale connections ; attention-weighted feature fusion ; Rotated-SARShip dataset (RSSD) ; object classification ; radar image reconstruction ; convolutional neural networks ; ResNet18 ; GBSAR ; Omega-K algorithm ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 105
    Publication Date: 2023-10-05
    Description: Updates the policy context of the Agency for Healthcare Research and Quality (AHRQ) patient safety initiative; documents the current priorities and activities undertaken; and assesses contributions of health information technology projects and dissemination actions to support adoption of evidence-based safe practices. Discusses implications for future AHRQ policy, programming, and research; suggests ways to strengthen AHRQ activities.
    Keywords: Health Sciences ; Management & Organizational Behavior ; Technology ; Political Science ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJM Management & management techniques::KJMV Management of specific areas::KJMV2 Personnel & human resources management ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBQ Medicolegal issues ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBG Medical equipment & techniques::MBGR Medical research ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 106
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This book contains research articles on the advances in the aetiology of idiopathic scoliosis (IS), the spinal growth related to the implementation of growth modulation for the surgical treatment of early-onset IS, the non-surgical treatment of IS using Physiotheraputic Scoliosis Specific Exercises, and braces. Additionally, it focuses on issues related to surgical treatment, issues related to body posture and the quality of life of this sensitive group of people. The high quality of published papers in this Special Issue of the JCM serve these objectives.
    Keywords: idiopathic scoliosis ; health-related quality of life ; cultural adaptation ; Italian Spine Youth Quality of Life Questionnaire ; systematic review ; meta-analysis ; adolescent idiopathic scoliosis ; brace therapy ; brace concepts ; rigid brace ; night time brace ; ring apophysis ; maturation ; ossification ; fusion ; scoliosis ; nighttime orthotic treatment ; surgery ; quality of life ; paraspinal muscles ; cross-sectional area ; posterior approach ; computed tomography ; Italian spine youth quality of life questionnaire ; SRS-22 ; 22q11.2 deletion syndrome ; human model ; neuromuscular scoliosis ; radiography ; MRI ; curve morphology ; intraspinal anomaly ; body height ; pulmonary function test ; Cobb angle ; iTRAQ ; α-actin ; progressive ; differentially expressed proteins ; bracing ; physiotherapeutic scoliosis-specific exercise ; physical activity ; adherence ; spinal appearance ; shared decision-making ; personalised approach ; sclerostin ; osteocytes ; β-catenin ; Wnt signaling pathway ; scoliometer ; truncal asymmetry ; lateral spinal profile ; surface topography ; aetiology ; spinal deformities ; pathobiomechanics ; follow-up study ; Rett syndrome ; motor skills ; telerehabilitation ; physical therapy modalities ; home exercise program ; neurodynamic functions ; assessment ; pain ; treatment ; early onset scoliosis ; non-operative treatment ; body posture ; sports activity ; corrective exercises ; digital photography ; n/a ; bic Book Industry Communication::M Medicine
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  • 107
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Advancements in medical imaging modalities have resulted in increasing the importance and demand of pediatric radiology. This reprint showcases various examples of advanced research in pediatric radiology and nuclear medicine. These include the use of medical imaging modalities such as computed tomography, general radiography, magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and ultrasound for diagnosis, as well as the performance of artificial intelligence (AI) in computer-aided detection and diagnosis in the pediatric population. The radiation dose issue of pediatric radiological examinations and emerging AI technology for dose reduction, as well as the use of three-dimensional printing based on medical images for pediatric surgical planning, healthcare professional education, and patient–clinician communication are also covered.
    Keywords: as low as reasonably achievable ; computed tomography ; convolutional neural network ; deep learning ; dose reduction ; generative adversarial network ; image processing ; machine learning ; medical imaging ; noise ; contrast-enhanced ultrasound ; head ultrasound ; brain death ; infants ; ancillary test ; child ; paediatric ; infant ; adolescent ; chest X-ray ; CXR ; chest radiography ; COVID-19 ; SARS-CoV-2 ; coronavirus ; biliary atresia ; ultrasonography ; diagnostic accuracy ; intraoperative cholangiography (IOC) ; diagnostic performance ; elastography ; three-dimensional printing ; congenital heart disease ; children ; model ; personalized medicine ; application ; confusion matrix ; disease identification ; image interpretation ; pneumonia ; artificial intelligence (AI) ; deep learning (DL) ; paediatric pneumonia ; chest radiograph ; computer-aided detection (CAD) ; cumulative ; radiation dose ; acute tonsillitis ; shear wave elastography ; stiffness ; pediatric ; magnetic resonance imaging ; infection ; neck ; emergency medicine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 108
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: With the deep integration of cutting-edge technologies such as artificial intelligence, big data, and the Internet, ship propulsion control systems are also gradually undergoing a transformation from the mode of automatic control to intelligent control. In particular, the smart ship concept has become a key factor in the maritime industry’s ambition to achieve sustainable green development. Currently, the development of all-electric propulsion and innovative hybrid ship propulsion systems is a priority, so that the efficiency of ship propulsion systems might be improved. Therefore, the aim of this monograph is to describe the intelligent control of ship propulsion systems. In this regard, this monograph deals with new approaches to the design of ship power systems. Among them, in terms of intelligent control, and using simulation experiments for comparison, the learning ability relied on by artificial intelligence is utilized to handle the collected data and generate corresponding commands, thus ensuring the safety and stability of the ship's movement. The main objective of this Special Issue is to fill existing knowledge gaps and provide additional ideas on the intelligent control of marine propulsion systems. Finally, we would like to express our deepest gratitude to the staff of MDPI Books and the editorial team of Marine Science and Engineering, especially the assistant editors of this Special Issue, the gifted authors, and the diligent and expert reviewers.
    Keywords: automation ; autonomous guidance ; green propulsion technologies ; marine engine ; safety and efficiency ; ship propulsion dynamics ; simulation ; smart control ; optimization ; weather routing ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 109
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In the last few years, huge amounts of progress have been made regarding remote sensing in the field of computer vision. This success and progress is mostly due to the effectiveness of deep learning (DL) algorithms. In addition, the remote sensing community has shifted its attention to DL, and DL algorithms have been used to achieve significant success in many image analysis tasks. However, with regard to remote sensing, a number of challenges caused by difficulties in data acquisition and annotation have not been fully solved yet. This reprint is a collection of novel developments in the field of remote sensing using computer vision, deep learning, and artificial intelligence. The articles published involve fundamental theoretical analyses as well as those demonstrating their application to real-world problems.
    Keywords: tropical cyclone detection ; meteorological satellite images ; deep learning ; deep transfer learning ; generative adversarial networks ; image target detection ; multiple scales ; any angle object ; remote sensing of small objects ; point clouds ; 3D tracking ; state estimation ; Siamese network ; deep LK ; convolutional neural networks (CNNs) ; multilayer feature aggregation ; attention mechanism ; remote sensing image scene classification (RSISC) ; hyperspectral image classification ; variational autoencoder ; generative adversarial network ; crossed spatial and spectral interactions ; crater detection algorithm (CDA) ; R-FCN ; self-calibrated convolution ; split attention mechanism ; transfer learning ; remote sensing ; oriented object detection ; rotated inscribed ellipse ; remote sensing images ; keypoint-based detection ; gated aggregation ; eccentricity-wise ; object detection ; remote sensing image ; anchor free ; oriented bounding boxes ; deformable convolution ; three-dimensional radar imaging ; convolution neural network ; super-resolution ; side-lobe suppression ; terahertz radar ; aerial image generation ; satellite image generation ; structure map ; style vector ; high resolution image ; self-constructing graph ; semantic segmentation ; GAN ; image generation ; data augmentation ; remote sensing disaster image ; convolutional neural network ; double-stream structure ; feedback ; encoder–decoder network ; dense connections ; instance segmentation ; Swin transformer ; cascade mask R-CNN ; remote sensing image retrieval ; hashing algorithm ; binary code ; triplet ordinal relation preserving ; cross entropy ; feature distillation ; forest fire ; smoke segmentation ; Smoke-Unet ; residual block ; Landsat-8 ; band sensibility ; unsupervised domain adaptation ; bidirectional domain adaptation ; image-to-image translation ; generative adversarial networks (GANs) ; U-Net ; high-density laser scanning ; logging trails ; digital surface model ; canopy height model ; commercial thinning ; convolutional neural networks ; multiview ; satellite and UAV image ; joint description ; image matching ; neural network ; contextual information ; Anchor Free Region Proposal Network ; polar representation ; 3D object detection ; point cloud ; sampling ; single-stage ; rotated object detection ; angle-based detector ; angle-free framework ; rotated region of interests (RRoIs) ; representative points ; plastic ; UAVs ; contrastive learning ; mutual guidance ; spatial misalignment ; vehicle detection ; ANN ; automatic classification ; risk mitigation ; machine learning ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 110
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: This reprint focuses on recent advancements, technical challenges, and novel design methodologies for the energy manufacturing system, including energy management, green manufacturing, sustainable manufacturing, energy saving in manufacturing systems, the operation and maintenance of power generation, prognostics and health management of power systems, and so on. With the increasing attention paid to sustainable development around the world, improving energy efficiency and applying effective means of energy saving have gradually received worldwide attention. As the largest energy consumers, manufacturing industries also inevitably face pressures on energy optimization evolution from both governments and competitors. The rational optimization of energy consumption in industrial operation activities can significantly improve the sustainability level of an entire company.
    Keywords: multi-level structure ; non-production energy consumption (NPEC) ; sub-batch priority ; multi-objective gray wolf optimizer (MOGWO) ; high-order hidden semi-Markov model ; composite node ; model reduction ; state duration ; polynomial fitting ; residual life prognosis ; wind turbines ; opportunistic maintenance ; structural correlation ; random correlation ; carbon emissions ; fault diagnosis technology ; improved convolutional neural network ; ship electrical power system ; Simulink ; synchronous generator ; hidden Markov model (HMM) ; autocorrelation ; residual chart ; failure mode ; effects and criticality analysis ; Z-number ; rough number ; DEMATEL method ; VIKOR method ; energy–carbon emissions nexus ; causal model ; low-carbon product ; future transport-manufacturing industries ; RV reducer ; assembly quality ; dendrites ; neural network ; transmission accuracy ; sustainable ; energy optimization ; operation and maintenance ; manufacturing systems ; automated storage and retrieval system ; hybrid flowshop ; genetic algorithm ; migratory birds optimization algorithm ; GA-MBO ; urban rail transit ; operational efficiency ; energy efficiency ; carbon emission ; data envelopment analysis ; preventive maintenance ; quality cost ; multiobjective optimization ; manufacturing system ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 111
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The 10th International Conference on Modern Circuit and System Technologies on Electronics and Communications (MOCAST 2021) will take place in Thessaloniki, Greece, from July 5th to July 7th, 2021. The MOCAST technical program includes all aspects of circuit and system technologies, from modeling to design, verification, implementation, and application. This Special Issue presents extended versions of top-ranking papers in the conference. The topics of MOCAST include:Analog/RF and mixed signal circuits;Digital circuits and systems design;Nonlinear circuits and systems;Device and circuit modeling;High-performance embedded systems;Systems and applications;Sensors and systems;Machine learning and AI applications;Communication; Network systems;Power management;Imagers, MEMS, medical, and displays;Radiation front ends (nuclear and space application);Education in circuits, systems, and communications.
    Keywords: incremental power and timing optimization ; Lagrangian relaxation ; gate sizing ; multimode multicorner ; physical optimization ; two-qubit states ; quantum computers ; quantum gates ; Rabi oscillations ; single qubit quantum computer ; quantum operations simulation ; vision transformers ; computer vision ; deep learning ; artistic style recognition ; memristor model ; tantalum oxide ; memory crossbar ; nonlinear dopant drift ; window function ; LTSPICE library memristor model ; stochastic computing ; stochastic filtering ; stochastic FIR filter ; unconventional computing ; electrical masking ; interconnection delay ; Single Event Multiple Transients ; Soft Error Rate ; STA ; TCAD ; timing-masking ; transient faults ; IoT ; wireless sensor networks ; hydroponics ; smart agriculture ; Network-on-Chip ; bufferless routing ; 3D NoC ; Markov chains ; visible light communication (VLC) ; wireless communication ; analog front end (AFE) ; pre-amplification ; classification ; COVID-19 ; lightweight neural network ; medical imaging ; chest X-rays ; image sensors ; 3D pixels ; 3D sequential integration ; 3DSI ; monolithic 3D ; M3D ; coupling ; parasitic capacitances ; memristor ; emulator ; analog design ; switched capacitor ; mixed signal ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 112
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This Special Issue aimed to collate recent works regarding the planning and control of energy systems. In particular, this Special Issue focuses on microgrids. This kind of system enables optimal integration of renewable energy sources, electric vehicles, energy storage, and demand-side management strategies, thus proposing a valuable framework through which to implement the decarbonization of the electricity sector. Special attention is given to those works devoted to systems with high penetration of renewables and advanced demand response strategies. Literature reviews are also included in this Special Issue, and some real-life experiences are described and analyzed.
    Keywords: optimization algorithm ; control system ; renewable energy ; PSO ; GWO ; battery storage energy ; electric vehicle ; photovoltaics ; BESS ; optimization ; AOA algorithm ; uncertainty ; distribution network ; DC multi-microgrid system ; carbon emissions ; economic dispatch ; across-time-and-space energy transmission ; cooperative multi-objective optimization ; PV ; wind turbine ; biomass system ; heap-based optimizer ; Franklin’s and Coulomb’s algorithm ; sooty tern optimization ; energy cost ; metaheuristics ; solar cell systems ; elephant herding optimization ; alpha tuned EHO ; cultural-based ; biased initialization ; parameter identification ; single diode ; double diode ; three diodes ; modular multilevel converter (MMC) ; fault-tolerant ; voltage source modular multilevel converter (VSMMC) ; SPWMLSC ; SPWMPSC ; STHILSC ; STHIPSC ; optimal energy management ; multi-agent system ; multi-energy carrier ; renewable energy sources ; microgrids management ; renewable energy resources ; isolated microgrids ; optimization techniques ; demand-side management (DSM) ; distributed generations (DGs) ; energy management systems (EMS) ; renewable energy sources (RES) ; waste to energy (W2E) ; microgrid architecture ; smart infrastructure ; resilience ; optimization model ; critical node identification ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 113
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: A full awareness of the role played by a healthy diet, as part of a healthy lifestyle, in countering or slowing-down chronic and degenerative diseases has strongly increased the interest in food bioactives and the return of ancient foods that are nowadays considered functional. In fact, these dietary substances, to which nutraceutical attributes are increasingly entrusted, could display disease-preventing effects on animals and humans. In this context, polyphenols, which are widespread and mostly copious in dietary plant sources, have gained a lot of attention thanks to their potential ability to halt or reverse oxidative stress-related diseases. Indeed, food could contain, beyond health-promoting compounds, toxicants which are naturally occurring or process-induced dietary compounds with adverse effects on human health. The presence and abundance of bioactives are strictly related to their food source. Edible plant components largely contain beneficial secondary metabolites, but understanding them fully is still an important challenge as complex biotic and abiotic interactions are involved in their biosynthesis. Analytical methods, which are increasingly powerful, could enhance our knowledge of food bioactives, whereas the deep investigation of their bioactivity and bioavailability could make them particularly useful.
    Keywords: Urtica dioica ; natural products bioactivity ; food bioactives ; nutraceuticals ; cancer therapy ; breast cancer ; Aloe vera ; Aloe vera polysaccharides ; in vitro fermentation ; SCFAs ; antioxidant capacity ; food waste recovery ; grape leaves ; UHPLC-HR-MS/MS analysis ; flavonol glycuronides recovery ; linoleic acid peroxidation products ; hexane ; gastric cells ; metabolomics ; cDNA microarray ; avocado ; LC/MS ; fat-soluble vitamins ; carotenoids ; Cannabis sativa L. ; phenylamides ; lignanamides ; hemp seeds ; high resolution tandem mass spectrometry ; U-87 glioblastoma cells ; cytotoxicity ; Pistacia vera ; antioxidant ; quality ; tocopherol ; FTIR ; discriminant analysis ; pistacia (Pistacia vera) hulls ; anticancer ; bacterial resistance ; efflux pumps ; terpenoids ; thymol ; carvacrol ; Rosmarinus officinalis L. ; fresh young shoots tincture ; polyphenols ; terpenes ; hepatoprotective ; n/a ; bic Book Industry Communication::M Medicine
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  • 114
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The reprint is devoted to the phenomena associated with exact or approximate axial symmetry in different areas of technical physics and mechanical engineering science. How can the symmetry of the problem be used most efficiently for its analysis? Why is the symmetry broken or why is it still approximately retained? These and other questions are discussed based on systems from different fields of engineering.
    Keywords: fretting wear ; axis-symmetry ; tangential contact ; torsional contact ; Abel transform ; injection molding ; concentricity ; coaxiality ; optical barrel ; bilateral telecentric lens ; optimization ; contact problem ; non-axisymmetric indenter ; extremal principle ; generalized MDR ; non-axisymmetric ; circular contact ; frictionless contact ; general solution ; closed-form solution ; series solution ; cylindrical punch ; contact stress-intensity factor ; cylindrical symmetry ; spherical symmetry ; periodic boundary conditions ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 115
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Gastrointestinal (GI) malignancies represent a diverse spectrum of cancers with notable global incidence and prevalence. The comprehensive care of individuals affected by these malignancies is a multifaceted endeavor involving the collaboration of various medical disciplines. The nonspecific clinical manifestations of GI cancers often present a formidable diagnostic challenge to primary care providers, resulting in diagnostic delays. Subsequently, the treatment regimens, once initiated, are often demanding and prolonged, and profoundly impact the patients' overall quality of life. Given the intricate involvement of the digestive system, nutritional concerns are pervasive among these patients, influencing both their quality of life and survival. Despite these considerable challenges, the evolving landscape of treatment modalities has yielded improved outcomes, enabling a greater number of patients to achieve remission or extended survival. It is now imperative that we delve deeper into understanding the unique needs of this patient population and refine the care delivery pathways through enhanced diagnostic approaches, treatment strategies, and holistic support, and ultimately enhance the overall value of care provided to individuals afflicted by GI malignancies.
    Keywords: HCV ; esophageal cancer ; male ; interferon ; mortality ; colorectal cancer ; gynecologic cancer ; retrospective cohort study ; colonoscopy screening ; gastric cancer ; ascites ; postoperative follow-up ; gastrectomy ; endoscopic submucosal dissection ; early gastric cancer ; type 2 diabetes mellitus ; glycemic control ; insulin resistance ; hepatocellular carcinoma ; annexin A2 ; prognostic marker ; survival outcome ; biliary tract cancer ; circulating tumor cell ; vimentin ; diagnosis ; prognosis ; gastric xanthelasma ; synchronous/metachronous gastric cancer ; genetic alteration ; predicting marker ; interval cancer ; screening ; endoscopy ; national cancer screening program ; c-Myc ; genetic linkage analysis ; cigarette smoking ; survival ; CRC ; CCL2 ; CCL4 ; CCL15 ; diagnostic utility ; gastrointestinal malignancies ; cancer survivorship ; calcium carbonate ; hypercalcemia ; cancer outcomes ; bic Book Industry Communication::M Medicine
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  • 116
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries.
    Keywords: infliximab ; etanercept ; TNFα inhibitors ; biologics ; biosimilars ; Germany ; policies ; incentives ; uptake ; market dynamics ; biosimilar market ; biosimilar/supply and distribution ; biosimilar sustainability ; Delphi technique ; pricing ; reimbursement ; utilization ; biosimilar ; biological ; information ; education ; communication ; patient ; Europe ; adalimumab ; biosimilarity assessment ; quality attributes (QAs) ; potentially critical quality attributes (pCQAs) ; European public assessment reports (EPARs) ; clinical governance ; Spain ; barriers ; regulatory ; review ; approval ; clinical ; queries ; regulatory science ; budget impact analysis ; savings ; pharmaceutical spending ; cost containment ; reference biological ; competitive market ; Belgium ; trastuzumab ; intravenous ; subcutaneous ; HER2-positive breast cancer ; drug costs ; healthcare costs ; cost simulation ; tender ; procurement ; off-patent ; award criteria ; switching ; interchangeability ; sustainability ; competition ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 117
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: The title of the current Special Issue, “Feature Papers in Materials Simulation and Design”, has identified the aims of this collection since its opening: the gathering of research works and comprehensive review papers that advance the understanding and prediction of material behavior at different scales, from atomistic to macroscopic, through innovative modeling and simulation.In this context, interdisciplinary researches that tackled challenging and complex material problems where the governing phenomena might span different scales of material behavior, with an emphasis on the development of quantitative approaches to explain and predict experimental observations, have been collected. Similarly, particular attention has been given to homogenization techniques for the evaluation of the mechanical properties of new materials and multi-phase composites. Innovative numerical approaches for the mechanical analysis, highlighting their accuracy, reliability, and stability features, have been also welcomed. Significant space has been also given to advanced and sustainable technologies. From the aforementioned topics, it is evident that this Special Issue represents the ideal forum for disseminating excellent research findings, as well as sharing innovative ideas in this significant field.Throughout the several months of activity, this Special Issue has been able to attract much interesting research. Its success is proven by the sixteen papers collected and published.
    Keywords: die height ; biomass compaction ; relaxation coefficient ; briquette density ; logging residues ; mechanical engineering ; scale opening mechanics ; seed extraction ; morphological structure ; numerical simulation ; computational fluid dynamics ; OpenFOAM ; cementitious materials ; Bingham rheology ; pumping ; reliability ; pentagon-based 2D material ; thermal conductivity ; thermoelectric properties ; anharmonicity ; additive manufacturing ; fused deposition modeling ; lattice structures ; TPU ; layering ; zirconia ceramics ; brittle medium ; porosity ; Kolsky method ; compressibility ; strength ; fracture ; stress growth rate ; light-harvesting ; water splitting ; photoferroics ; high-throughput screening ; Ruddlesden-Popper perovskites ; high-pressure water jet ; high-pressure water-ice jet ; paint coating ; geometric structure of the surface ; base ; surface efficiency of the process ; renovation ; acrylonitrile butadiene styrene ; artificial neural networks ; dynamic mechanical properties ; Particle Swarm Optimization ; green composite ; bumper beam ; numerical modeling ; energy absorption ; natural fibers ; axial vibration ; short-fiber-reinforced ; Fourier series ; nonlocal elasticity ; thin-walled ; FEM ; thermal buckling analysis ; tungsten trioxide ; graphene oxide ; photocatalysis ; nanocomposite ; composite laminate ; mode-II delamination ; R-curve ; temperature ; cohesive law ; nonlinear hyperelastic material ; viscoelasticity ; semi-analytical polynomial method ; large deformation ; finite element method ; numerical methods ; thin shells ; variable-stiffness structures ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 118
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Researchers have made great progress in the mechanism of mycotoxins biosynthesis, pathogenicity, and the construction of detection methods. This collection holds fundamental and applied research on pathogenic fungi and mycotoxins in China, which directly or indirectly affect the health of plants, animals, and humans. Some papers mainly study the mechanism of mycotoxin biosynthesis, including the crucial genes, environmental factors, and regulation mechanisms, which is beneficial to advancing our knowledge of this area. Some papers focus on the toxicity of mycotoxins, which is helpful to the detoxification of mycotoxins and the reduction of the hazardous effect of mycotoxins. Special attention is given to the leading detection methods, especially on-site rapid detection. These effective and feasible methods are important for discovering and controlling the risk of mycotoxins.
    Keywords: water activity ; aflatoxin biosynthesis ; conidia development ; regulatory mechanism ; AtfB ; fumonisin B1 ; BALB/c mice ; fecal bacterial flora ; 16S rRNA sequencing ; zearalenone ; gilts ; ovary ; hormone ; weaned gilt ; intestinal morphology ; ghrelin ; PCNA ; farmers’ grain storage silos ; absolute water potential ; ventilation and drying ; mycotoxins ; contamination distribution ; Alternaria toxins ; modified QuEChERS method ; ultra-high-performance liquid chromatography-tandem mass spectrometry ; mixed fruit puree ; Aspergillus flavus ; AflN ; aflatoxin ; conidiation ; rice false smut ; ustiloxins ; generic antigen ; immuno-magnetic beads ; enzyme-linked immunity ; hepatotoxicity ; nephrotoxicity ; haematological toxicity ; regulatory limit ; αB-conotoxin VxXXIVA ; epitope ; hybridoma ; monoclonal antibody ; ELISA ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 119
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: This Special Issue delves deeply into the intricate distinctions between acute and chronic pain. Crucially, chronic pain is more than a mere by-product of sensory input; it entails the activation of a complex brain network intertwined with biopsychosocial factors. As such, its management emerges as a formidable clinical challenge. Within the scope of this Special Issue, focused attention is given to postoperative pain (POP) and chronic postsurgical pain (CPSP). POP, characterized by its predictability, intensity, and short duration, contrasts starkly with the potentially persistent and troublesome nature of CPSP, which can endure for over three months if not adequately addressed. The prevention of CPSP takes on paramount importance, with regional anesthesia techniques emerging as promising tools for intervention. The pivotal role of multimodal analgesia and combined therapeutic strategies is underscored. The Special Issue also delves into the intriguing realm of gender differences in pain perception, advocating for further research to illuminate these disparities. Risk factors contributing to the development of chronic pain following surgery are meticulously identified. Lastly, this Special Issue explores the potential of new technologies in the field of telemedicine and artificial intelligence to optimize care delivery, opening new avenues for enhanced patient outcomes and treatment strategies.
    Keywords: Postoperative pain ; Chronic postoperative pain ; Pain mechanisms ; Postoperative pain management ; Physiopathology of chronic postoperative pain ; Opioids ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 120
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: The great economic and strategic importance of catalysis makes it a rapidly evolving field. Catalysis is fundamental in areas such as sustainable development, energy production, environmental protection, food production, and water purification. In the face of the significant challenges of the present day, acquiring fundamental knowledge about the structure and phenomena on the surface of catalysts and the relationships between the composition, synthesis method, properties, and performance of catalysts in industrial processes is essential. Research is still needed to improve existing catalysts or design new systems which may efficiently and selectively conduct a given reaction toward the desired product. This Special Issue was devoted to designing and characterizing heterogeneous catalytic systems for industrial chemical processes. The reprint collects 10 research articles providing insight into important aspects of modern catalyst design. The papers cover recent advances and comprehensive experimental studies of synthesis, characterization, and evaluation of catalyst performance in the following processes: ammonia synthesis, selective catalytic reduction of nitrogen oxides, hydrogen production from ethanol, and photocatalysis.
    Keywords: cobalt molybdenum nitrides ; ammonia synthesis ; phase composition ; specific surface area ; cobalt catalyst ; barium ; promoter ; optimization ; hydrogen ; ethanol ; catalyst ; TiO2 photocatalysis ; UV-C ; photolysis ; ammonia ; nitrogen removal ; water treatment ; hydrogen production ; ethanol steam reforming ; nickel-based catalyst ; manganese oxides ; potassium promoter ; gliding discharge ; plasma–catalytic system ; tar decomposition ; nickel catalyst ; nitric acid plant ; selective catalytic reduction ; clinoptilolite ; iron-modified zeolite catalyst ; TiO2-SiO2 ; mesoporous ; F127 ; high surface area ; solar photocatalysis ; dye degradation ; structure sensitivity ; size effect ; carbon support ; neodymium oxide ; support ; hydrogen poisoning ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 121
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The second volume of the Special Issue on “Micro-Electro Discharge Machining: Principles, Recent Advancements and Applications” confirms the growing interest in the micro-EDM technology as a suitable and efficient technology for machining novel, multilateral components, with demanding requirements in terms of precision, accuracy, and productivity.This volume consists of 10 original research papers which involve several approaches to micro-EDM and cover the enhancement of the process performance, such as the material removal rate, surface roughness, or machining accuracy, using advanced optimization methods. Some studies also consider several dielectric fluid additives and investigate the processability of new materials. Others investigate the combination of Reverse-micro-EDM with laser beam micromachining or explore new applications for the micro-EDM for fabricating antimicrobial nanosilver colloid.
    Keywords: electrical discharge machining ; metal matrix composite ; Taguchi ; micro-hardness ; surface roughness ; material removal rate ; wire electro-discharge machining ; polymer composite materials ; processing precision ; interelectrode gap ; micro-EDM milling ; accumulative difference ; material removal ; tool electrode wear ; analytical hierarchy process ; residual stress ; metal erosion rate ; Reverse-μEDM ; Nd: YAG LBµM ; micro-holes ; burrs ; protrusions ; electrical discharge machine ; energy consumption ; nanosilver colloid ; antimicrobial ; micro-EDM ; tungsten carbide ; carbon nanofiber ; silicon ; alumina ; shape memory alloys ; nitinol ; optimization ; near-dry wire electric discharge machining (WEDM) ; teaching–learning based optimization (TLBO) algorithm ; micro electrical discharge machining ; vibration assisted electrical discharge machining (EDM) ; high-speed camera ; array electrode ; structured surface ; efficiency ; micromachining ; performance ; quality ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 122
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Lipid-based nanosystems, including solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), cationic lipid nanoparticles, nanoemulsions, and liposomes, have been extensively studied to improve drug delivery through different administration routes. The main advantages of these systems are their ability to protect, transport, and control the release of lipophilic and hydrophilic molecules (either small-molecular-weight molecules or macromolecules); the use of generally recognized as safe (GRAS) excipients that minimize the toxicity of the formulations; and the possibility to modulate pharmacokinetics and enable the site-specific delivery of encapsulated payloads. In addition, the versatility of lipid-based nanosystems has further been demonstrated for the delivery of vaccines, the protection of active cosmetic ingredients, and the improvement of moisturizing properties of cosmetic formulations.Lipid-based nanosystems are well established and there are already different commercially approved formulations for various human disorders. This success has paved the way for the diversification of the pipeline of development, to address unmet medical needs for several indications, such as cancer, neurological disorders, and autoimmune, genetic, and infectious diseases.This Special Issue aims to update readers on the latest research on lipid-based nanosystems, both at the preclinical and clinical levels. A series of 15 articles (six reviews and nine studies) is presented, with authors from 12 different countries, showing the globality of the investigations that are being carried out in this area.
    Keywords: Echinococcus granulosus ; scolicidal ; nanoliposome ; juglone ; apoptotic activity ; hydrogel ; SLNs ; nose-to-brain delivery ; mucoadhesion ; quality by design ; antioxidant activity ; nasal administration ; nanostructured lipid carriers ; solid lipid nanoparticles ; in vitro cell cultures ; 3D nasal casts ; lung cancer ; targeted drug delivery ; lipid-based nanocarriers ; pulmonary delivery ; dry powder inhalers ; aerosols ; liposomes ; nanoemulsions ; nanotechnology ; biologically active compounds ; dermal drug delivery ; polyphenols ; phytophenols ; skin permeation ; chemotherapy ; radiotherapy ; active targeting ; passive targeting ; tumor ; immunoconjugate ; traditional liposome ; stealth liposome ; triggered release ; limitations of liposomes ; drug transfer ; in vitro release ; colloidal drug carriers ; lipid nanoparticles ; hydrogel beads ; cholesteryl nonanoate ; bovine serum albumin ; skin diseases ; lipid-based nanosystems ; cream ; ointment ; gel ; pH-sensitive ; liposome ; imidazole ; anticancer ; drug delivery ; multicellular spheroids ; dapagliflozin ; Box–Behnken design ; FTIR ; DSC ; XRD ; SEM ; AFM ; in vitro Franz diffusion cells ; lipid-based nanoparticles ; nanocarrier ; surface charge ; delivery systems ; chronic treatment ; mice ; anti-oxidant activity ; hepatoprotective effect ; phospholipid ; phytosomes ; Silymarin ; Colorectal Cancer ; Niosomes ; Oxaliplatin ; Paclitaxel ; d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) ; therapeutic nucleic acids ; schizophrenia ; quetiapine fumarate ; glycerosomes ; central composite rotatable design ; bioavailability ; pharmacokinetic ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Advanced sensing, fault diagnosis, and structural health management are important parts of the maintenance strategy of modern industries. With the advancement of science and technology, modern structural and mechanical systems are becoming more and more complex. Due to the continuous nature of operation and utilization, modern systems are heavily susceptible to faults. Hence, the operational reliability and safety of the systems can be greatly enhanced by using the multifaced strategy of designing novel sensing technologies and advanced intelligent algorithms and constructing modern data acquisition systems and structural health monitoring techniques. As a result, this research domain has been receiving a significant amount of attention from researchers in recent years. Furthermore, the research findings have been successfully applied in a wide range of fields such as aerospace, manufacturing, transportation and processes.
    Keywords: structural health monitoring ; wireless sensor network ; steel-framed construction ; corrosion ; pulsed eddy current ; tethered satellite formation ; dynamic behavior ; control ; stable deployment ; Floquet theory ; Francis turbine unit ; prognostic ; performance state evaluation ; degradation trend prediction ; DBSCAN ; Gaussian mixture model ; NSGA-II ; Gaussian process regression ; pipeline ; fatigue crack ; stress intensity factor ; finite element ; XGBoost ; bolt axial stress ; acoustoelastic effect ; scattering attenuation ; stress-dependent attenuation coefficient ; sensitive frequency band ; triaxial force transducer ; wide-range ; dynamic calibration ; Hopkinson bar ; sensitivity matrix ; status evaluation ; mining XLPE cables ; membership cloud ; D-S evidence theory ; PZT ; smart aggregate ; ECC beam ; damage monitoring ; aeromagnetic survey ; OBE interference compensation ; LSTM network ; rust detection ; transmission lines fitting ; object recognition ; faster R-CNN ; transmission safety ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The development of in vivo neuroimaging techniques has yielded an incredible amount of digital information about the brain. Neuroimaging techniques are increasingly being used to study human cognitive processes, create brain–machine interfaces, and also to identify and diagnose certain brain disorders. Currently, neuroscientists and medics actively use different methods for brain scans, including electro- and magnetoencephalography (EEG/MEG), functional near-infrared spectroscopy (fNIRS), electrocorticography (ECoG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and diffusion tensor imaging (DTI). Recent advances in signal processing and machine learning for neuroimaging data using various signal processing methods have made impressive progress in solving a number of practical tasks in medicine, healthcare, neuroscience, biomedical engineering, brain–machine interfaces, and cognitive science, to name but a few. This Special Issue aims to provide a forum for academic and industrial communities to present and discuss the latest theoretical and experimental results related to recent advances in neuroimaging data processing in terms of new theories, algorithms, architectures, and applications.
    Keywords: MEG ; FieldTrip ; Brainstorm ; source reconstruction ; flickering ; cognitive neuroscience ; visual perception ; detrended fluctuation analysis ; long-range correlations ; electroencephalogram ; sleep deprivation ; nonstationarity ; transfer entropy ; kernel methods ; Renyi’s entropy ; connectivity analysis ; phase interactions ; brain data ; low-cost devices ; EEG ; BIDS ; neuroscience ; library ; ambiguous stimuli ; Necker cubes ; classification task ; EEG analysis ; wavelet analysis ; decision time ; perceptual errors ; time-on-task effect ; brain connectivity ; artificial neural networks ; granger causality ; time series ; brain–computer interface ; event-related potential ; beamforming ; regularization ; BCI ; graphical user interface ; wheelchair navigation ; grid map ; natural landmark ; optimal paths ; deep Q-networks ; focal epilepsy ; diffusion imaging ; electroencephalography ; structure-function coupling ; seizure onset ; structural connectivity ; functional connectivity ; cognitive load ; coupling ; bubble entropy ; transition network ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Non-destructive testing and evaluation are commonly referred to as the vast group of analysis techniques used in civil, medical, and industrial sectors to evaluate the properties of materials, tissues, components, or structures, without causing any damage. Automation offers many benefits for non-destructive testing to cope with increasing demands, including improved reliability and higher inspection speeds. Additionally, robots enable inspections in locations that are not easily accessible to human operators and allow for humans to be removed from potentially dangerous environments. However, the perceived complexity and high costs have limited the adoption of automation. As a result, the full potential that could be derived from the seamless integration of robotic platforms with sensors, actuators, and software has not been fully explored; it could still revolutionise the way that automated inspections are performed and conceived. The recent advancements in electronics, robotics, sensor technology and software pave the way for new developments in automated testing and data-driven autonomous robotic inspections in several sectors. This Special Issue aimed to attract the latest research outcomes in the field of robotic sensing. Five papers relate to inspection systems based on robotic fixed-base manipulators, three of which are associated with in-process inspection in manufacturing applications (robotic wire-arc welding and additive manufacturing). Four papers report research advancements in mobile robotic-enabled sensing.
    Keywords: wall-climbing robot ; passive adaptive mechanism ; magnetic circuit optimization ; flexible detection method ; welding robot ; seam tracking ; laser sensor ; feature point extracting ; complex welding seam ; UAVs ; inspection ; soft robotics ; non-destructive evaluation ; robotic NDE ; robotic welding ; robotic control ; in-process NDE ; ultrasonic NDE ; ultrasound ; image motion analysis ; image processing ; optical flow ; underwater robotic ; NDT ; free-form surface profiling ; autonomous robotic systems ; in-process robotic NDE ; Wire + Arc Additive Manufacture (WAAM) ; ultrasound testing ; total focusing method ; defect recognition ; aircraft inspection ; deep learning ; CNN ; UAV ; defect classification ; AI ; underwater vehicle–manipulator system ; robotics emulator ; contact management ; remote inspection ; force control ; automated eddy current testing ; eddy current arrays ; robotics ; thermography ; non-destructive testing ; image alignment ; image blending ; n/a ; bic Book Industry Communication::M Medicine
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  • 126
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: The year 2021 marks the 10th anniversary of Journal of Clinical Medicine, and as one of the major sections of JCM, we are launching a 10th anniversary Special Issue in the section “Gastroenterology & Hepatopancreatobiliary Medicine”. We accepted papers for the Special Issue, titled "Recent diagnostic and therapeutic advance in Gastroenterology & Hepatopancreatobiliary Medicine". This medical field is a complex and wide-ranging field that deals with diseases in multiple organs such as the gastrointestinal tract and hepatobiliary pancreas. With recent advances in diagnostic imaging and interventional treatment, those in endoscopic diagnosis and treatment, those in functional test and those in genetic diagnosis and drug therapy, including the molecular-targeted therapy, many new medical findings have been accumulated. In this Special Issue, we looked for reports that make full use of advances in diagnostics and therapeutics in the field of Gastroenterology and Hepatopancreatobiliary Medicine.
    Keywords: TXI ; sessile serrated lesion ; hyperplastic polyp ; colonoscopy ; endoscopic submucosal dissection ; colorectal tumor ; traction method ; carbon dioxide ; CO2 insufflation ; abdominal pain ; abdominal distention ; transnasal endoscopy ; health check ; tranexamic acid ; gastrointestinal bleeding ; mortality ; thromboembolic events ; liver metastases ; colorectal liver metastases ; non-colorectal and non-neuroendocrine liver metastases ; liver resection ; Crohn’s disease ; biologics ; small-molecule drugs ; health-related quality of life (HRQoL) ; gastric cancer ; gastric cancer screening ; endoscopy ; H. pylori ; eradication therapy ; n/a ; functional bowel disorders ; gut microbiota ; personalized diet ; machine learning ; personalized medicine ; Turkey ; machine perfusion ; normothermic ; hypothermic ; liver transplant ; survival ; ustekinumab ; perianal fistula ; radiological fistula remission ; metastatic pancreatic carcinoma ; FOLFIRINOX ; sarcopenia ; oxaliplatin ; L3 skeletal muscle index ; percutaneous endoscopic gastrostomy ; prognostic factor ; bic Book Industry Communication::M Medicine
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  • 127
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: This reprint focuses on the research of textile materials for conventional and protective clothing. More than ever, multidisciplinary research applied to the field of new textile materials and new techniques of processing and joining materials is needed. The main research topics of this Special Issue include research and development of new materials and the improvement of their properties, and the mechanical and thermal properties of yarns, materials and clothing. Simulations based on the physical and mechanical properties of fabrics for the purpose of prediction assessment of the appearance and behavior of clothing, as well as 3D virtual garment prototypes using 3D body models and involving 3D human-body scanning, are interesting and significant topics in the field of clothing engineering. The problem of microplastics that are produced during the manufacture or cleaning of synthetic textiles has also been investigated in this Special Issue.
    Keywords: electroconductive material ; polyamide ; silver ; shielding effectiveness ; wet cleaning ; dry cleaning ; polyurethane ; material ; clothing ; mechanical properties ; heat resistance ; woven fabric ; plain weave ; electrically conductive yarn ; resistance ; tensile force ; elongation ; knit ; plain stitch ; multi-filament yarn ; 3D model ; stretching ; air permeability ; fashion design ; textile material ; textile pattern ; thermal camouflage ; biomimetic ; leather ; drape coefficient ; leather rigidity ; drapability ; leather thickness ; kinematic 3D human-body model ; sitting posture ; Blender software ; virtual prototyping ; personalized clothing ; linen fabric ; warp crimp ; calculated crimp ; experimental crimp ; moisture vapor permeability ; ecofriendly fiber ; Tencel ; bamboo ; KES-F7 ; pore diameter ; fabric ; drape ; physical and mechanical properties ; polygonal model ; 3D simulation ; linen/silk fabric ; pilling resistance ; singeing ; pigment and reactive printing ; electrospinning ; nanofibres ; filtration ; particles retention ; multilayer systems ; clothing physiology ; tight-fitting sportswear ; running test on a treadmill ; thermal comfort ; skin temperature ; perspiration ; protective clothing for firefighters ; flame manikin ; fire resistant materials ; flammability of materials ; thermal decomposition ; microplastics ; wastewater ; textiles ; polyester ; polyester ageing ; bibliometric analysis ; research trend ; artificial intelligence ; Web of Science ; 3D printing ; textile applications ; polylactic acid (PLA) ; breaking force ; knee protector ; FR fabric ; printing ; wash fastness ; spectrophotometry ; cotton fabric ; Proban® ; environmentally friendly washing procedure ; flame retardant durability ; MCC ; appearance ; knitted fabric ; cycle load ; elastic limit ; elastane ; hysteresis curve ; socks ; modal ; micro modal ; yarn type ; durability ; comfort ; textile testing ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint covers topics on geographical scale of glacier and lake ice variations, as well as the engineering scale of ice properties and their practical applications via laboratory tests and numerical modeling.
    Keywords: level ice ; ice resistance ; probability distribution ; polar ship ; circumferential crack method ; ice phenology ; Eurasia ; analytical model ; climate ; altitude ; spatial statistics ; glacier resources ; glacier inventory ; climate change ; topography ; Xinjiang ; polar ships ; propeller ; ice blockage ; cavitation effect ; EFD-CFD ; Manas river basin ; Kaidu river basin ; glacier mass balance ; Geographical detector ; attribution analysis ; arctic oil and gas resources ; Kulluk platform ; mooring system ; ice load ; ice-structure interaction ; sea ice ; fresh-water ice ; parametrization scheme ; melting rate ; laboratory study ; unmanned aerial vehicles ; SIFT algorithm ; brutal force matching ; RANSAC algorithm ; ice velocity ; blasting under ice ; dynamic simulation ; blasting volume ; parameter analysis ; collaborative bearing capacity ; analytic hierarchy process ; SD model ; simulation prediction ; Ulan Suhai Lake ; lake ; wetlands ; optical satellite data ; cloud ; Wuliangsu Lake ; ship ice accumulation ; sea spray ; marine structures ; SPH-FEM coupling method ; distilled water ice ; uniaxial compressive strength ; growth temperature of ice ; strain rate ; grain size ; ice core ; fabric ; microstructure ; glacial shear margin ; Dalk Glacier ; river ice ; thickness ; GPR ; temperature ; Yellow River ; water resources from melted glaciers ; lake ice phenology ; ice properties ; ice engineering ; ecosystem under lake ice ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    Publication Date: 2023-10-05
    Description: Sino-Singapore Guangzhou Knowledge City is a planned environmentally and technologically advanced city in China’s Guangzhou Development District that will host innovative industries and their workers. This report serves as an outline for a set of strategies for Knowledge City and is intended to help the developers create conditions that are conducive to innovation and the commercialization of new technologies.
    Keywords: Business ; Technology ; History ; Economics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCM Development economics & emerging economies ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies.
    Keywords: ciguatoxins ; HRMS ; Q-TOF ; ciguatera poisoning ; C-CTX1 ; fragmentation pathways ; maitotoxins ; Gambierdiscus ; Fukuyoa ; LC-MS/MS ; QToF ; neuroblastoma cell assay ; matrix effect ; ciguatera monitoring ; SPATT passive samplers ; HP20 resin ; CBA-N2a ; WS artificial substrate ; qPCR ; HTS metabarcoding ; ciguatera ; ciguatoxin ; cytotoxicity assay ; ELISA ; HPLC ; immunoassay ; mouse bioassay ; receptor-binding assay ; ciguatoxins (CTXs) ; neuroblastoma cell-based assay (CBA) ; immunosensor ; pacific ciguatoxins ; natural product ; polycyclic ether ; ring-closing metathesis ; Tsuji-Trost allylation ; French Polynesia ; epidemiology ; toxicological analyses ; risk management ; climate change ; Gambierdiscus polynesiensis ; toxin profile ; nitrate ; urea ; culture medium acidification ; CTX1B ; 52-epi-54-deoxyCTX1B ; 54-deoxyCTX1B ; Dictyota ; Caribbean ; dinoflagellate ; benthic algae ; algal toxin ; harmful algal bloom ; the Indian Ocean ; Arabian sea ; Kuwait bay ; Aden Gulf ; Red Sea ; Gulf of Aqaba ; Andaman Sea ; Bay of Bengal ; seafood safety ; foodborne disease ; experimental exposure ; lionfish ; trophic transfer ; toxin accumulation ; Selvagens Islands ; morphology ; phylogeny ; benthic dinoflagellate ; Beibu Gulf ; Chinese waters ; least absolute shrinkage and selection operator ; machine learning ; data science ; medical informatics ; survival analysis ; foodborne diseases ; Ciguatera Fish Poisoning ; digital technologies ; open data ; risk analysis ; marine biotoxins ; Lagodon rhomboides ; pinfish ; bioaccumulation ; depuration ; Caribbean ciguatoxin ; growth dilution ; model ; kinetics ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This reprint showcases a selection of bleeding-edge articles about medical image processing and segmentation workflows based on artificial intelligence algorithms. The proposed papers are applied to multiple and different anatomical districts and clinical scenarios.
    Keywords: fundus image ; image registration ; deep learning ; computer vision applications ; nuclei segmentation ; histopathology ; Grad-CAM ; semantic segmentation ; instance segmentation ; nuclei detection ; pap smear ; cervical net ; shuffle net ; canonical correlation analysis (CCA) ; support vector machine (SVM) ; random forest (RF) ; k-nearest neighbour (KNN) ; artificial neural network (ANN) ; dual-energy CT ; two-step method ; limited-angular range ; directional total variation ; PA ; CNN ; tooth disease recognition ; image segmentation ; image preprocessing ; breast cancer ; mitotic nuclei classification ; histopathology images ; artificial hummingbird algorithm ; medical imaging ; cervical cancer ; feature fusion ; feature selection ; deep learning structures ; support vector machine ; disease discrimination accuracy ; performance comparisons ; 2D/3D registration ; orthogonal X-ray ; breast density ; CAD ; image enhancement ; textural ; auto-segmentation ; neuroimaging ; magnetic resonance imaging ; ovarian tumor ; 2D ultrasound image ; image inpainting ; lesion segmentation ; attention mechanism ; GAN ; medical image analysis ; synthetic CT ; MRI guidance ; MRI-only ; image-guided radiotherapy ; carbon ion radiotherapy ; particle therapy ; rare tumor ; PCNSL ; radiomics ; image normalization ; MRI ; prostate cancer ; prostate segmentation ; U-Net ; mp-MRI ; loss function ; automatic volume measurement ; ultrasound bladder scanner ; edge computing ; urinary disease ; artificial intelligence ; mandible ; segmentation ; 3D virtual reconstruction ; CBCT ; CT ; Convolutional Neural Networks ; comparison ; in-house ; software ; patch size ; Cranio-Maxillofacial surgery ; DICOM ; osteoarthritis ; histopathological ; hematoxylin eosin ; safranin O fast green ; DarkNet-19 ; MobileNet ; NasNet ; ResNet-101 ; ShuffleNet ; PCA ; ALO ; ensemble learning ; OCT ; pyramidal network ; scale-adaptive ; teeth segmentation ; panoramic radiographs ; mask-transformer-based networks ; panoptic segmentation ; tuberous sclerosis complex ; children ; convolutional neural network ; multi-contrast MRI ; rare neurodevelopmental disorder ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Billions of people suffer from dental problems. Paradoxically, the deteriorating state of teeth is accompanied by the ever-increasing desire to preserve the best facial appearance, which is significantly influenced by teeth aesthetics. This favors the development of dental materials and manufacturing technologies for dental prosthetics, needed to achieve expected effects of clinical treatment.This reprint focus on enhancing antimicrobial and mechanical properties of polymeric materials and composites for dentistry. In recent years, special attention has been focused on the possibility of giving materials new or improved properties by the introduction of nano or submicron size additives, fibers or whiskers. Using agents such as natural oils to enhance antimicrobial properties remains an exciting idea. Another area of research is the application of antibacterial monomers, which can be copolymerized in resins to kill oral pathogenic microflora. The use of new monomers or new compilations of various monomers to improve mechanical properties has also aroused interest. In addition, we are currently looking for new data regarding colonization of dental materials by pathogenic microbes and their influence on the other properties. Further, there are many new commercially available materials which should be investigated to verify their properties, which is important from the point of view of clinical practice. Original new research and reviews related to any of the topics mentioned above indicate the current directions of development of dental materials. We hope that the presented work will be of interest to readers.
    Keywords: dental cements ; ethanol ; water ; resistance ; DTS ; Vickers hardness ; dental materials ; dimethacrylates ; polymer networks ; structure ; morphology ; degree of conversion ; crosslink density ; physical crosslinking ; hydrogen bonds ; mechanical properties ; water sorption ; polymethyl methacrylate ; denture ; antibacterial properties ; silver ; sorption ; solubility ; wear resistance ; FRC ; bonding ; technique ; fiber ; reinforced ; composite ; spot ; mechanical ; deflection ; orthodontics ; brushing ; wear ; retainer ; splint ; load ; direct pulp capping ; indirect pulp capping ; ProRoot MTA ; MTA Angelus ; retroMTA ; biodentine ; theraCal LC ; ACTIVA BioACTIVE ; vital pulp therapy ; glass fiber ; composite post ; endodontic therapy ; etching ; post and core technique ; silane ; glass-ionomer cements ; resin-modified ; fibre ; reinforcement ; nanoparticles ; testing ; strength ; P2O5-bioglass ; zirconia ; melt-quenching ; SBF ; hydroxyapatite ; in vitro bioactivity ; essential oils ; oral pathogens ; antibacterial activity ; S. mutans ; L. acidophilus ; C. albicans ; antifungal activity ; resin composite ; wettability ; biofilm formation ; cytotoxicity ; polymers ; antimicrobial properties ; infiltrants ; metronidazole ; dental ceramics ; spectroscopy ; IR ; FT-IR ; Raman spectroscopy ; UV-Vis ; X-ray spectroscopy ; XRF ; XRD ; MS ; dental resins ; UDMA ; Bis-GMA ; Bis-EMA ; TEGDMA ; hardness ; water absorption ; water dissolution ; CAD-CAM ; inlay ; lithium disilicate ; zirconium dioxide ; root caries ; infiltration ; microstomatology ; adhesive ; bracket ; dentures ; denture adhesives ; human fibroblasts ; composite resins ; Streptococcus mutans ; dental caries ; bacterial adhesion ; oleic acid ; PMMA ; filamentation ; biofilm ; antimicrobial surface ; Candida albicans ; colonization ; penetration ; dimethacrylate copolymers ; quaternary ammonium methacrylates ; urethane-dimethacrylates ; photocurable copolymers ; water behavior ; thermoplastic materials ; laboratory protocol ; texture ; roughness ; biomaterial ; polymer ; microbial degradation ; artificial saliva ; mucins ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This Special Issue reprint, “Advanced Polymer Nanocomposites II”, addresses high-quality original and review papers, focused on the scientific discussion and practical application in the field of functional polymer nanocomposites, including: (a) optoelectronic materials (papers 1-9); (b) biomedical materials (papers 10-14); and (c) other functional polymer nanocomposites (papers 15-23). We hope that this Special Issue reprint can promote academic research exchanges and identify and respond to tremendous challenges of research in this burgeoning field.
    Keywords: hexagonal boron nitride ; jet cavitation ; silicone ; thermal conductivity ; silica sol ; soft contact lens ; poly(HEMA-co-NVP) ; oxygen permeability ; hydrophilicity ; POSS ; phenolic resin ; hydrogen bonding ; supercapacitors ; parylene ; CVD ; bioremediation ; polymer ; cellulase ; Bacillus ; Li4Ti5O12 ; polyimide ; carbon coating ; lithium ion battery ; rate performance ; polyaniline ; ferrite ; α″-Fe16N2 ; superparamagnetic ; inverse suspension polymerization ; β-tricalcium phosphate ; biocomposites ; osteoconduction ; polycaprolactone ; epoxy resin ; nanocomposites ; silica nanoparticles ; mechanical behavior ; high strain rate ; split Hopkinson bar ; FeNC catalyst ; polyimine ; two-stage calcination ; oxygen reduction reaction ; bone tissue regeneration ; chitosan nanocomposites ; critical size defect ; graphene oxide ; titanium dioxide nanoparticles ; polymer electrolytes ; composites ; biopolymers ; zinc batteries ; magnesium batteries ; properties ; graphene ; carbon nanotubes ; electromagnetic interference shielding ; Nepenthes structure ; bionic replica ; zwitterion polymers ; self-driving water ; unidirectional water delivery ; surface-enhanced Raman scattering (SERS) detection ; cable joint ; liquid silicone rubber ; nonlinear conductivity ; space charge ; magnetic nanomaterials ; conjugated polymers ; poly-N-phenylanthranilic acid ; one-step synthesis ; IR heating ; natural rubber latex ; Bi2O3 ; BaSO4 ; X-ray shielding ; gloves ; mechanical properties ; poly ionic liquids ; nanofibers ; electrospinning ; gold nanoparticles ; hybrid nanocomposites ; polyurethanes ; solution blow spinning ; dielectrics ; superparamagnetic iron oxide nanoparticles (SPION) ; dry coating ; solvent-free process ; discrete core-shell coating ; propargyl methacrylate (PMA) ; mesoporous carbon microbeads (MCMB) ; solid electrolyte interface (SEI) ; reinforcement ; nanocomposite ; application ; supramolecular micelle ; C60 ; hydroxyl radical scavenger ; surface-enhanced Raman scattering detection ; water pollutants ; bionic nanostructure ; silver nanoislands ; thermal evaporation ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: When adopting remote sensing techniques in precision agriculture, there are two main areas to consider: data acquisition and data analysis methodologies. Imagery and remote sensor data collected using different platforms provide a variety of information volumes and formats. For example, recent research in precision agriculture has used multispectral images from different platforms, such as satellites, airborne, and, most recently, drones. These images have been used for various analyses, from the detection of pests and diseases, growth, and water status of crops to yield estimations. However, accurately detecting specific biotic or abiotic stresses requires a narrow range of spectral information to be analyzed for each application. In data analysis, the volume and complexity of data formats obtained using the latest technologies in remote sensing (e.g., a cube of data for hyperspectral imagery) demands complex data processing systems and data analysis using multiple inputs to estimate specific categorical or numerical targets. New and emerging methodologies within artificial intelligence, such as machine learning and deep learning, have enabled us to deal with these increasing data volumes and the analysis complexity.
    Keywords: vineyard ; pesticide application ; variable rate application ; unmanned aerial vehicle ; satellite ; nanosatellite ; monsoon crops ; leaf area index ; leaf chlorophyll concentration ; crop water content ; multispectral ; hyperspectral ; deep learning ; forage dry matter yield ; high-throughput phenotyping ; Brazilian pasture ; nitrogen indicator ; nitrogen nutrition diagnosis ; optical sensor ; spectral index ; UAV ; wheat lodging ; lightweight ; digital surface model (DSM) ; winter wheat ; fractional order differential ; continuous wavelet transform ; optimal subset regression ; support vector machine ; wheat powdery mildew ; machine learning ; information fusion ; remote sensing monitoring ; hyperspectral imaging ; dimensionality reduction ; LDA ; PLS ; PCA ; RandomForest ; ReliefF ; XGB ; Meloidogyne ; Solanum tuberosum ; soil salinity sensitive parameter ; random forest ; optimal retrieval model ; remote sensing ; high throughput phenotyping ; UAV/drone ; biomass estimation ; oats ; wheat ; yield prediction ; random forests ; satellite imagery ; Normalized Difference Vegetation Index (NDVI) ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: In this Special Issue, we sought advanced knowledge in both basic and clinical research presented in original articles and comprehensive reviews highlighting the latest advances in MCC. Articles focus on but were not restricted to the molecular basis of the disease, translational investigations of biomarkers for prospective clinical applications, and innovative diagnostic and therapeutic approaches in MCC.
    Keywords: miR-375 ; antagomiRs ; Merkel cell carcinoma ; Hippo signaling ; focal adhesion ; diagnosis ; treatment ; review ; guideline ; Merkel cell polyoma virus ; tumor microenvironment ; CD8 lymphocytes ; ulceration ; E-cadherin ; artesunate ; MCC ; polyomavirus ; ferroptosis ; radiation therapy ; immunotherapy ; surgical intervention ; survival ; multidisciplinary communication ; biomarkers ; cell tropism ; signaling pathways ; therapy ; transgenic mice ; tumorigenesis ; histogenesis ; ATOH1 ; GLI1 ; sonic hedgehog ; hair follicle ; Merkel cell polyomavirus ; skin carcinogenesis ; T antigens ; human polyomaviruses ; DNA tumor viruses ; viral oncoproteins ; merkel cell carcinoma ; merkel cell polyoma virus ; sex ; radiotherapy ; UV ; cell line ; MYC ; TP53 ; RB1 ; whole-exome ; significantly mutated genes ; copy number variation ; virus positive Merkel cell carcinoma ; virus negative Merkel cell carcinoma and copy number variant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: With increasing requirements for energy, resources and space, rock engineering projects are being constructed more often and are operated in large-scale environments with complex geology. Meanwhile, rock failures and rock instabilities occur more frequently, and severely threaten the safety and stability of rock engineering projects. It is well-recognized that rock has multi-scale structures and involves multi-scale fracture processes. Meanwhile, rocks are commonly subjected simultaneously to complex static stress and strong dynamic disturbance, providing a hotbed for the occurrence of rock failures. In addition, there are many multi-physics coupling processes in a rock mass. It is still difficult to understand these rock mechanics and characterize rock behavior during complex stress conditions, multi-physics processes, and multi-scale changes. Therefore, our understanding of rock mechanics and the prevention and control of failure and instability in rock engineering needs to be furthered. The primary aim of this Special Issue “Mathematical Problems in Rock Mechanics and Rock Engineering” is to bring together original research discussing innovative efforts regarding in situ observations, laboratory experiments and theoretical, numerical, and big-data-based methods to overcome the mathematical problems related to rock mechanics and rock engineering. It includes 12 manuscripts that illustrate the valuable efforts for addressing mathematical problems in rock mechanics and rock engineering.
    Keywords: rock mechanics ; rock engineering ; mathematical problem ; dynamic mechanics ; rock classification ; macroscopic deformation ; thermal treatment ; cooling condition ; acoustic emission ; pollution evaluation ; open-pit rock blasting ; extreme learning machine ; dynamic response ; freeze-and-thaw damage ; intelligent prediction ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: In the treatment of acute stroke, thrombolysis and thrombectomy have proven to be highly effective. Many patients have seen significant improvement after reperfusion therapy. This reprint aims to address current knowledge gaps and promote advancements in the use of thrombolysis and thrombectomy for the treatment of acute ischemic stroke.
    Keywords: ischemic stroke ; acute kidney injury ; contrast media ; endovascular treatment ; outcome ; hyperglycemia ; acute ischemic stroke ; large vessel occlusion ; mechanical thrombectomy ; stroke ; ischemia ; machine learning ; cerebral infarction ; biomarkers ; recanalization therapy ; reperfusion ; temperature ; time to admission ; prehospital delay ; prior stroke ; basilar artery ; brain ischemia ; intracranial atherosclerosis ; embolism ; infarction ; clinical symptoms ; intravenous thrombolysis ; endovascular therapy ; recanalization times ; clinical outcome ; hypoperfusion index ratio ; collateral circulation ; collateral scoring ; CTA ; CTP ; thrombolysis ; C-reactive protein ; white blood cell count ; prognosis ; hypoperfusion ; collaterality ; thrombectomy ; frailty ; elderly patients ; hospital frailty risk score ; acute stroke ; perfusion imaging ; CT perfusion ; MR perfusion ; RAPID ; fasting hyperglycemia ; fasting normoglycemia ; long-term outcome ; hemorrhagic transformation ; parenchymal hematoma ; GWAS ; single nucleotide variants ; anterior circulation ; bridging therapy ; recanalization ; stroke risk score ; COVID-19 ; Lithuania ; reperfusion therapies ; outcomes ; safety ; prehospital stroke diagnosis ; ultrasound ; brain perfusion ; SONAS® ; prehospital stroke scales ; point-of-care diagnostics ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: This is a reprint of the Special Issue entitled “Wood-Based Materials in Building” and deals with the latest developments in reinforcing construction materials, their joining, glulam–concrete composite beams, the effect of fire-retarding wood on its strength, and the applicability of newly developed wood-based boards and composite insulation materials produced with the use of wood by-products.
    Keywords: timber–timber joints ; single-step joint ; double-step joint ; resource efficient construction ; digital image correlation ; finite element analysis ; wood ; fire retardants ; artificial ageing ; compression strength ; polyurethane foam ; wood by-products ; filler ; cellular structure ; performance properties ; bolts ; dowels ; dowel-type fasteners ; FEM ; frame connection ; fully threaded screws ; glued laminated timber ; numerical model ; rotational stiffness ; bark ; chipboard ; sawdust ; wood-based material ; wood chips ; formaldehyde emission ; mechanical properties ; UF resin ; plywood ; wood-base materials ; bolts and dowels ; apex connection ; folding mechanism ; FEA ; panelized light frame roof ; glulam-concrete composite beam ; timber board interlayer ; bending performance ; finite element model ; parametric study ; glued laminated beams ; fibre-reinforced timber ; load-bearing capacity ; stiffness ; ductility ; modulus of elasticity ; bending test ; carbon cords ; carbon laminates ; knots ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    RAND Corporation
    Publication Date: 2023-10-05
    Description: Is the United States in danger of losing its competitive edge in science and technology? This volume reviews the arguments surrounding this issue and contrasts them with relevant data, including trends in research and development investment; information on the size, composition, and pay of the U.S. science and engineering workforce; and domestic and international education statistics. The authors conclude with recommendations for policymakers.
    Keywords: Technology ; Management & Organizational Behavior ; Education ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJW Office & workplace::KJWX Working patterns & practices ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: As Editor-in-Chief of the journal Diabetology, I am pleased to announce that the Special Issue “Diabetology: Feature Papers 2022” has now been published as a reprint. Diabetology (ISSN 2673-4540) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to the epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In this Special Issue, “Feature Papers”, we aimed to publish outstanding contributions in the main fields covered by the journal, which will make a great contribution to the community. This reprint covers the whole spectrum of diabetology from risk screening, risk markers, pathways of disease in type 1 diabetes and insulin treatment, and management of the disease and comorbidities.
    Keywords: older people ; diabetes mellitus ; management ; insulin therapy ; frailty ; sarcopenia ; type 1 diabetes ; type 2 diabetes ; insulin ; beta cell preservation ; verapamil ; thioredoxin-interacting protein (TXNIP) ; Chronic Care Model ; self-management of type 2 diabetes ; chronic disease ; healthcare system of Pakistan ; patients’ quality of life ; obstructive sleep apnoea ; DM ; obesity ; inflammation ; polysomnography ; coronavirus disease 2019 ; COVID-19 ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; diabetes ; diabetic ketoacidosis ; DKA ; hyperglycemia ; mortality ; innate immunity ; cytokine storm ; angiotensin-converting enzyme 2 ; pancreatic β-cell damage ; pediatrics ; HbA1c ; telemedicine ; continuous glucose monitoring ; prediabetes ; liver enzymes ; rhenium (V) compound ; triglycerides ; NAFLD ; fructose ; injection technique ; lipohypertrophy ; sodium glucose co-transporter 2 (SGLT2) inhibitors ; nocturia ; sodium intake ; key informant interviews ; prevention of type 2 diabetes ; National DPP ; DSMES ; telehealth ; provider experiences ; lipodystrophy ; clinical detection ; recommendations ; rehabilitation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Non-metallic inclusions have a great influence on the cleanliness and mechanical properties of steel. Controlling the size and composition of inclusions contributes to the excellent properties of “clean steel”. At the same time, in terms of our understanding of inclusions’ behavior using thermodynamics principles, the design and control of the composition, shape, size, and distribution of non-metallic inclusions in different steels can significantly enhance steel properties. This reprint introduces the latest developments in inclusion engineering, aiming to control the cleanliness and microstructure of steel through thermodynamic calculations and experimental work. Special attention is paid to the formation mechanism and evolution of inclusions during refining and solidification in real steel plants, the aggregation and floating of inclusions, and the kinetics of inclusion adsorption by refining slag.
    Keywords: MnS ; inclusion ; cerium ; sulfur ; fracture ; Cr5 ; back-up roller ; forged ingot ; large-size inclusions ; SiO2-MnO-Al2O3 ; contact angle ; aluminum deoxidation ; magnetic particle inspection ; defects ; nonmetallic inclusion ; cleanliness ; Ti-bearing IF steel ; reoxidation ; long producing process ; U75V heavy rail steel ; Cerium treatment ; gleeble ; MgO saturation ; industrial trial ; non-metallic inclusions ; thermodynamic calculation ; nonmetallic inclusions ; MgO-Al2O3 ; CaO-MgO-Al2O3 ; thermodynamic ; kinetic ; electroslag remelting ; evolution ; CAFE ; equiaxed crystal ratio ; macrosegregation ; numerical simulation ; continuous casting ; process optimization ; rare earth Ce ; inclusions ; modification ; non-oriented silicon steel ; rare earth oxysulfides ; rare earth La–Ce ; magnetic property ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Electronic cigarettes (ECs) have been present on the consumer market for over a decade, and the number of related scientific publications in the PubMed database has now exceeded seven thousand. Despite the number of publications, there is still no consensus in the scientific community regarding their safety. However, it should be emphasized that a comparison of equivalent quantities of tobacco smoke and the aerosol produced from e-cigarettes showed that there was a significantly lower quantity of toxic compounds in the aerosol compared with the tobacco smoke. Therefore, the use of ECs could be seen as a way of reducing the health damage to cigarette smokers who cannot or are unwilling to quit using conventional methods. In addition, randomized studies are emerging suggesting that ECs could be useful in smoking cessation. On the other hand, ECs are now widely used among adolescents and may pose a serious risk of future nicotine dependence and health problems in this population, as they counteract their advantages in the population gained from smokers who quit using them. Therefore, as most authors stress, further research that will convincingly resolve the current controversies is needed. Clinicians urgently need evidence-based knowledge to better inform their patients about the use of these emerging tobacco products as a harm-reduction strategy, and regulators should regulate these products in ways that best serve public health, especially taking the youth population into account.
    Keywords: e-cigarettes ; global health ; vaping ; tobacco smoke ; toxicants ; cessation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: In the last century, the average life expectancy at birth increased from roughly 45 years in the early 1900s to more than 80 years of age at present. However, living longer is often related to different levels of frailty. There is no curative treatment for frailty—the interventions that have been described as effective to slow or delay the onset of frailty are physical activity and nutritional interventions. Maintaining adequate nutrition status is important to reduce the risk of chronic diseases, many of which are age-related. On the other hand, frailty itself may have a negative effect on eating and, thus, on the nutritional status. This Special Issue, "Nutrition, Diet Quality, Aging and Frailty", addresses the existing knowledge on nutrition regarding the causative factors of frailty and disease due to aging, i.e., strategies for delaying the pathological effects of aging. It consists of twelve peer-reviewed papers covering original research, protocol development, methodological studies, narrative or systematic reviews, and meta-analyses, to better understand these complex relationships.
    Keywords: diet ; metabolism ; nutrient ; glucose ; lipid ; insulin ; neuroinflammation ; Alzheimer’s disease ; anti-ageing ; eating habits ; functional foods ; skin ageing ; breakfast ; meals ; older adults ; protein intake ; hyperhomocysteinemia ; vitamin B deficiency ; amyloid beta-peptides ; disease models ; animal ; memory and learning tests ; dietary diversity ; activities of daily living ; cohort study ; adults ; mortality ; QOL ; ADL ; Serum albumin ; self-assessed chewing ability ; inflammaging ; cognitive impairment ; cytokines ; physical frailty ; aged ; dietary inflammatory index ; dietary patterns ; frailty ; inflammation ; muscle function ; muscle mass ; sarcopenia ; prevalence ; nutrition ; physical activity ; meta-analysis ; meta-regression ; dairy products ; dietary pattern ; malnutrition ; food groups ; Mediterranean dietary pattern ; Westernized dietary pattern ; cross-sectional study ; aging ; lifespan ; carbohydrates ; whole grain ; protein ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories.
    Keywords: developmental origins of health and disease (DOHaD) ; gut microbiota ; hypertension ; short chain fatty acid ; oxidative stress ; probiotics ; prebiotics ; renin–angiotensin system ; fibroblast growth factor-23 ; left ventricular hypertrophy ; renin–angiotensin–aldosterone system ; losartan ; canrenone ; Hyp mice ; X-linked hypophosphatemia ; hairless SHRM ; cold acclimation ; cardiac Cx43 ; extracellular matrix ; thyroid hormones ; SHR ; sacubitril/valsartan ; ARNI ; ivabradine ; remodelling ; cardiac dysfunction ; fibrosis ; angiotensin II ; angiotensin 1-7 ; knock-out ; genome-editing ; SHRSP ; Dahl SS ; foetal programming of hypertension ; sympathetic neurotransmission ; sympathetic innervation ; vascular remodelling ; foetal undernutrition ; old SHR ; antihypertensive therapy ; blood pressure monitoring ; LV hypertrophy ; ECM markers ; cardiac fibrosis ; SHR-CRP ; SGLT-2 inhibitor ; gene expression ; age ; lipid metabolism ; nitric oxide ; l-NAME ; rostral ventrolateral medulla ; aging ; reactive oxygen species ; NADPH oxidase activator 1 ; mitochondria ; chloride ; calcium-activated chloride channel ; Na+–K+–2Cl− cotransporter 1 ; TMEM16A ; smooth muscle ; fetal undernutrition programming ; cross-fostering ; lactation period ; cardiovascular hypertrophy ; adipose tissue browning ; cardiovascular disease ; catecholamines ; liquid chromatography–tandem mass spectrometry ; SGLT-2 inhibition ; proteinuria ; uninephrectomized salt-loaded ; two-kidney ; one-clip hypertension ; fawn-hooded hypertensive rat ; ApoE KO ; apolipoprotein E knockout mice ; atherosclerosis ; Na,K-ATPase ; TCTP ; TCTP-overexpressing transgenic mice ; translationally controlled tumor protein ; TCTP-TG ; experimental hypertension ; bone ; rats ; taurine ; magnesium ; 24 h urine(24U) ; stroke-prone spontaneously hypertensive rat ; young SHR ; combination therapy ; treatment effect ; systolic blood pressure ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This reprint aims to promote and disseminate applied research in the field of corrosion of steel structures and technological equipment. Within the text, the focus is firmly placed on the detailed study of corrosion processes affected by specific environments, as well as on the effects of corrosion damage on the reliability and service life of structural components and technological equipment. Special attention is paid to the study of the impact of corrosion processes on pipelines.
    Keywords: Q235B steel ; desulfurization solution ; corrosion mechanism ; pitting corrosion ; high pressure and high temperature ; O2–CO2 coexistence environment ; flow-induced corrosion ; reinforcing steel ; corrosion ; chloride ; experiment ; bow shaped device ; concrete ; cathodic protection ; buried pipelines ; rust layer ; electrochemical acceleration test ; applied current density ; required current ; low-alloy steel ; SEM ; inclusion ; anodic dissolution ; steel pipeline ; in-line inspection results ; interacting corrosion defects ; structural integrity ; galvanostatic test method ; underground infrastructure ; long-term corrosion ; carbon steel ; ASTM A516-65 steel ; weld ; hydrogen-induced cracking ; galvanic corrosion ; sour environment ; vinyltrimethoxysilane ; silane ; sol–gel ; response surface methodology ; Box–Behnken design ; modeling ; soil environment ; carbon steel corrosion ; stray current corrosion ; pipeline ; calcareous deposit ; corrosion mitigation ; failure analysis ; low-carbon steel pipe ; aluminum inclusions ; pearlite inhomogeneity ; steel structures ; crevice corrosion ; lattice towers ; bolted lap joints ; weathering steel ; experimental tests ; numerical modelling ; corrosion current density ; sulfate ; galvanized steel ; alkaline solutions ; linear polarization resistance ; electrochemical impedance spectroscopy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: The challenges in identifying effective therapies for CNS tumors continue to be daunting. Potentially effective targeted therapies must be able to penetrate the blood–brain barrier to reach the tumor and, in sufficient concentrations, to result in meaningful treatment responses. Moreover, molecular targets must be key drivers in the growth and progression of CNS tumors. Numerous potentially efficacious therapies have failed in randomized clinical trials due to other factors, including subclonal genetic intratumoral heterogeneity (particularly within malignant gliomas), epigenetic heterogeneity, and failure to target important factors involved in the tumor microenvironment. Developing effective targeted therapies requires a thorough fundamental understanding of the genetic and epigenetic factors driving tumor progression, the interactions between CNS tumor cells and the tumor microenvironment, and the key mechanisms of tumor treatment resistance. In this Special Issue, experts in the field of CNS tumors will highlight the most promising molecular targets in the development of treatments for patients with CNS tumors.
    Keywords: glioblastoma molecular classification ; ERK/MAPK pathway ; PI3K/PTEN pathway ; receptor tyrosine kinase ; EGFR ; PDGFRA ; FGFR3 ; MET ; EPHB2 ; NF1 ; immunotherapy ; glioblastoma ; blood–brain barrier ; central nervous system ; T cells ; T lymphocytes ; PCNSL ; CNS lymphoma ; methotrexate ; novel therapies ; novel therapeutics ; neurofibromatosis ; low grade glioma ; plexiform neurofibroma ; vestibular schwannoma ; glioma ; tumor mutation burden ; neoantigen ; immune score ; germline mutation ; antigen processing and presentation ; ependymoma ; subependymoma ; RELA ; YAP1 ; ZFTA ; PFA ; PFB ; MYCN ; Group A ; Group B ; myxopapillary ; targeted therapy ; diffuse midline gliomas ; molecular targets ; potential therapy development ; intraparenchymal metastases ; CNS disease ; metastatic disease ; tyrosine kinase inhibitors ; monoclonal antibodies ; Warburg effect ; mass spectrometry ; isotope labeling ; cancer metabolism ; pediatric brain tumor ; adenosine ; tumor microenvironment ; A2AAR antagonist ; immune evasion ; adenosine receptors ; bevacizumab ; temozolomide ; progression ; biomarker ; neoplastic ; meningitis ; leptomeningeal ; chemotherapy ; radiotherapy ; intrathecal ; GBM ; U87MG ; A172 ; Metformin ; LPS ; antioxidant ; cell cycle arrest ; apoptosis ; low-grade glioma ; preclinical models ; IDH-mutant glioma ; patient avatars ; methylation ; methylomics ; G-CIMP ; MGMT ; DNMT ; ATRX ; H3K27M ; CpG island ; tumor suppressor ; methyltransferases ; histone acetylation ; brain tumor ; brain metastasis ; lung cancer ; lung malignancy ; progression-free survival ; epidermal growth factor receptor ; lung carcinoma ; molecular therapy ; whole-brain radiation therapy ; stereotactic radiosurgery ; KIF11 ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: International experts contribute to Fractional- and Integer-Order System: Control Theory and Applications, providing an authoritative overview of the most recent developments in control theory as well as practical examples of fractional- and integer-order systems. Generously referenced and illustrated, the reprint highlights the growing interest in control science and is an invaluable resource for applied and industrial mathematicians, biological, control, electrical and electronics engineers and scientists.
    Keywords: fractional fourier transform ; weighted-type fractional fourier transform ; multiweighted-type fractional Fourier transform ; unitarity ; direct autotuning methods ; indirect autotuning methods ; fractional-order controllers ; simulation results ; interval analysis ; interval estimator ; finite-time convergence ; bounded uncertainties ; infectious diseases ; SEIR epidemic model ; fractional calculus ; neutral systems ; fixed-point theory ; distributed interval observer ; fractional-order multiagent systems ; monotone system theory ; generalized Caputo derivate ; fractional diffusion equation ; finite difference method ; collocation method ; error ; stability and convergence analysis ; autonomous underwater vehicle ; fuzzy logic control ; particle swarm optimization algorithm ; initial value problem ; fractional differential systems ; fractional integral equation ; infinite-state approach ; Riemann–Liouville integral ; frequency distributed exponential function ; fractional-order differential equations ; verification of pseudo-state enclosures ; Mittag-Leffler-type enclosures ; exponential enclosures ; fractional order ; synchronization ; event triggered ; uncertain ; n/a ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KNT Media, information & communication industries::KNTX Information technology industries ; bic Book Industry Communication::U Computing & information technology::UY Computer science ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 148
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Fresh fruit and vegetables are considered as essential components of a healthy human diet, due to their pleasant taste and rich nutrients. However, fruits and vegetables are characterized by production seasonality, regionality, and perishability, which greatly affect the acceptance of consumers and increase the challenges of their post-harvest storage and preservation. A plurality of preservation technologies, including chemical treatment (calcium chloride, 1-methylcyclopropene, salicylic acid, etc.), physical methods (low-temperature conditioning, controlled atmosphere storage, ultraviolet-C irradiation, etc.), and biotechnology (such as genetic engineering technology) have been applied to maintain storage quality and to extend the storage life of fresh fruit and vegetables in recent years. Developing advanced preservation techniques to prolong the storage life of fruit and vegetables is of importance for improving social and economic benefits. Therefore, we invited authors to contribute original research articles and review articles focused on the innovative preservation technology of fresh produce, addressing storage problems, such as post-harvest quality deterioration caused by senescence, physiological disorders, and disease, to extend the shelf-life of fresh produce and reduce post-harvest loss.
    Keywords: tomato ; bacteriocin ; soft rot ; biocontrol ; vegetable preservation ; loquat fruit ; calcium chloride ; chilling injury ; reactive oxygen species ; ascorbate–glutathione cycle ; chive ; senescence ; quality ; antioxidant capacity ; amino acids ; organosulfur compounds ; peptide PAF56 ; citrus fruit ; changes cell structure ; spores ; membrane permeability ; acetic acid ; decontamination ; lactic acid ; pitaya fruit ; p-Anisaldehyde ; reactive oxygen species (ROS) ; AsA-GSH cycle ; antioxidant activity ; ripening ; enzymatic activities ; anthracnose ; shelf-life ; cold shock ; MAP ; cucumber ; storage ; VOCs ; photodynamic inactivation (PDI) ; antimicrobial ; biofilm ; fresh-cut pakchoi ; preservation ; hydrogen sulfide ; antioxidant enzyme ; energy ; proline ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 149
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Humans and animals are continuously exposed to different unwanted actions of compounds, including mycotoxins present in food, water, and air. The presence of mycotoxins is a reason for different disease states or tissue and organism dysfunction. New work should facilitate a more accurate description of the degree of species sensitivity and more efficient dietary management, using environmental influences to improve plant material and animal health quality during primary production. On the other hand, better knowledge of the different forms of enzymes participating in mycotoxin biotransformation would enable more efficient preventive and therapeutic actions in many disease states in which the aetiology was not fully understood until now.
    Keywords: zearalenone ; digestive tract ; carryover factor ; ERs mRNA ; CYP1A1 mRNA ; GSTP1 mRNA ; pre-pubertal gilts ; low doses ; carry-over ; myocardium ; vascular reactivity ; mastitis ; ovarian cysts ; pyometra ; hepatic portal system ; dairy cows ; biosensors ; deoxynivalenol ; immunosensors ; feed ; antibody ; aptamer ; molecularly imprinted polymer ; low dose ; bone marrow microenvironment ; haematology ; AMH ; cattle ; long-term monitoring ; sub-clinical contamination ; SAA ; urine ; intestines ; CYP1A1 and GSTπ1 ; prepubertal gilts ; amoxicillin ; doxycycline ; Ussing chamber ; swine jejunum mucosa explants ; gonads ; hypothalamus ; pituitary gland ; steroid hormones ; immunohistochemistry ; oestrogen receptors ; gilts before puberty ; n/a ; bic Book Industry Communication::M Medicine
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  • 150
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Blockchain applications in different industries are booming, yet there are many unresolved challenges with the mass adoption of the technology. This reprint is an attempt to review some of the applications in different industries and propose solutions to some of the critical challenges in technology adoption.
    Keywords: distributed ledger technology ; blockchain ; decentralized applications ; technology review ; development guidelines ; architecture ; anti-counterfeiting ; decentralization ; product authenticity ; end-to-end traceability ; supply chain integrity ; supply chain provenance ; NFC-Enabled Anti-Counterfeiting System ; Near-Field communication ; Internet-of-Things ; Internet of Things ; information technology ; innovation ; supply chains ; transparency ; traceability ; safety ; food systems ; transactions ; smart contracts ; electrical network frequency (ENF) ; Proof-of-ENF (PoENF) ; consensus ; security ; Internet of Video Things (IoVT) ; proof of work ; proof of stake ; consensus mechanism ; 51% attack ; double-mining attack ; technological development ; scalability ; storage ; data integrity ; performance ; smart contract ; M2X ; smart autonomous devices ; e-governance ; lifecycle management ; smart grid ; internet of vehicles ; demand response ; systematic literature review ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 151
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: It was recently reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Human and industrial activities generate various forms of residual wastes and by-products in a solid, liquid, or gaseous state. Waste generation starts with simple processes such as living, eating, and breathing. Managing waste and minimizing associated environmental impacts have become more challenging as worldwide populations and economies continue to grow. Once these hazardous chemicals are present in the environment, people can become exposed to them. Human health can be influenced by many factors, including exposure to physical, chemical, biological, and radiological contaminants in the environment.This reprint comprises research papers related to the aspects of environmental exposure to multiple toxic chemicals and human health. The manuscripts are focused on toxicology, biomonitoring, exposure and risk assessment, and endocrine disruptors.
    Keywords: pesticide ; insecticide ; herbicide ; fungicide ; rheumatoid arthritis ; autoimmune disease ; n/a ; ovary ; endocrine disruptors ; follicular growth ; hormonal secretions ; gene expression ; bisphenols ; plasticiser ; ewe ; tetracyclines ; sulfonamides ; quinolones ; streptomycines ; meat ; antibiotics ; risk assessment ; air pollution ; endothelium ; inflammation ; cardiovascular disease ; ALS ; Alzheimer’s ; Aβ1–42 ; α synuclein ; children ; cerebrospinal fluid ; cisternal CSF ; fronto-temporal dementia ; Metropolitan Mexico City ; nanoparticles ; olfactory bulb granule cells ; PM2.5 ; Parkinson’s ; hyperphosphorylated tau ; TDP-43 ; cadmium ; crab ; crustaceans ; heavy metal toxicity ; nutrition ; pollution ; biomagnification ; biomonitoring ; benchmark dose ; BMDL ; BMDU ; creatinine clearance ; chronic kidney disease ; eGFR ; NOAEL ; urine cadmium ; plant protection products ; residential exposure ; agriculture ; Africa ; exposure pathway ; intake dose ; temporal variations ; spatial variations ; pollutants ; women exposure ; microRNAs ; PAHs ; paint production plant ; volatile organic compounds (VOCs) ; inhalation exposure ; cancer risk ; non-cancer risk ; economic loss ; subway PM exposure ; health burden ; long-term mortality ; morbidity ; 3-PBA ; pyrethroid pesticides ; pregnancy ; newborn ; anthropometry ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 152
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Special Issue is intended to lay the foundation of AI applications focusing on oral health, including general dentistry, periodontology, implantology, oral surgery, oral radiology, orthodontics, and prosthodontics, among others.
    Keywords: machine learning ; artificial intelligence ; malocclusion ; diagnostic imaging ; active learning ; maxillary sinusitis ; convolutional neural network ; deep learning ; segmentation ; oral microbiota ; LEfSe ; PCoA ; alloprevotella ; prevotella ; core microbiota ; artificial neural networks ; oral cancer diagnosis ; oral cancer prediction ; pit and fissure sealants ; caries assessment ; visual examination ; clinical evaluation ; convolutional neural networks ; transfer learning ; deep learning network ; YOLOv4 ; mandibular third molar ; inferior alveolar nerve ; contact relationship ; panoramic radiograph ; deep learning methods ; caries diagnosis ; dental panoramic images ; radiography ; Fourier transform infrared spectroscopy ; FTIR imaging ; spectral biomarker ; multivariate analysis ; discriminant model ; oral squamous cell carcinoma ; oral epithelial dysplasia ; oral potentially malignant disorder ; risk stratification ; early oral cancer detection ; dentigerous cysts ; histopathology images ; image classification ; odontogenic keratocysts ; radicular cysts ; AI ; screening ; diagnosis ; dentistry ; ultrasonography ; tongue ; algorithm ; dysphagia ; impacted ; tooth ; detection ; neural networks ; proximal caries ; training strategy ; small dataset ; periapical radiograph ; X-ray ; tooth extraction ; oroantral fistula ; operative planning ; n/a ; bic Book Industry Communication::M Medicine
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  • 153
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The 5th conference on sustainability in civil engineering was held online on August 03, 2023, by the Department of Civil Engineering of Capital University of Science and Technology, Islamabad, Pakistan. The major topics included green construction materials and structures, construction management, and resilient infrastructure and environment. A total of 133 submissions from the UK, Ireland, Canada, Australia, Italy, Cyprus, China, Kazakhstan, Nigeria, Malaysia, KSA, and Pakistan were received. All papers had undergone a comprehensive and critical double-blind review process. In total, 57 reviewers from 16 different countries reviewed papers. In the conference, nine9 speakers delivered keynote lectures, and 56 accepted papers were presented. Civil engineers from academia and industry shared their practical experiences and different research findings.
    Keywords: Civil Engineering ; Sustainability ; Construction Materials ; Composite Materials ; Modern Materials ; Structural Material Behavior ; Structural Analysis ; Structural Design ; Earthquake Engineering ; Engineering Dynamics ; Building Information Modelling (BIM) ; Project Management for Sustainable Development ; Sustainability in Construction Projects ; Construction Safety ; Construction Contracts ; Smart and Sustainable Construction ; Construction Waste Management ; IT applications in Construction ; Environmental Engineering ; Environmental Sciences ; Irrigation Engineering ; Water Resource Engineering &amp ; Management ; Highway &amp ; Traffic Engineering ; Urban &amp ; Transportation Planning ; Geotechnical Engineering ; Geological Engineering&nbsp ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 154
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This reprint is of interest regarding contaminated sites remediation, which integrates the research results within 20 publications covering contaminated sites remediation's full life cycle. They include pollution investigation, environmental fate, pollution control, and review. In addition, the reprint addresses all aspects of contaminated site remediation, including heavy metal pollution, organic pollution, and combined pollution. These results can help to understand the remediation of the contaminated sites in depth throughout the life cycle and help break through the bottleneck of contaminated sites remediation and provide new ideas and methods for the development of contaminated sites remediation.
    Keywords: magnetic composites ; tetracycline ; adsorption ; advanced oxidation processes ; solid waste ; soil contamination ; biochar ; Brassica campestris L. ; Cd ; Pb ; hexavalent chromium ; chrome plating site ; pollution distribution ; leachability ; speciation ; site investigation ; in situ pXRF ; multivariate adaptive regression splines (MARS) ; heavy metals ; rapid field screening ; bone char ; hydrogen peroxide treatment ; cadmium ; adsorption mechanism ; ion interchange ; BDE-209 ; soil suspension ; photodegradation ; products ; mechanism ; surface sediment ; ecological risk assessment ; Pearl Bay ; heavy metal ; sediment ; ecological risk ; Shantou Bay ; copper ; water spinach ; antioxidant enzymes ; microbial community ; tailings pond ; form ; rhizosphere ; miscanthus floridulus ; electroplating factory ; groundwater ; soil ; multivariable analysis ; environmental evaluation ; penetration curve ; petroleum pollution ; PHE ; soil column ; typical oilfields ; vertical migration ; soil remediation ; cadmium contamination ; recent advances ; challenges and prospects ; winter jujube ; Yellow River Delta ; granular-activated carbon ; polybrominated diphenyl ethers ; Triton X-100 ; soil-washing effluent ; density functional theory calculation ; human-health risk ; numerical simulation ; polyethylene ; phenanthrene ; soil properties ; soil enzyme ; pyrite ; AMD ; surface passivation ; band bending ; lead ; ecotype ; accumulation and translocation ; Cr(VI) ; migration ; model ; slag ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 155
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint focuses on novel findings of diagnostic dermatopathology, such as diagnosable new morphological (histopathologic) findings, immunohistochemical and immunofluorescent markers, and molecular techniques. Dermatopathology is the most sophisticated area in anatomic pathology; we can easily observe superficial skin lesions using our eyes without the need for an invasive approach and can easily compare gross configurations to microscopic and immunohistochemical findings. Meanwhile, dermatopathology has recently focused on the study of various cutaneous diseases at the molecular biology level. Many cutaneous diseases are now being well-researched, and special attention is paid to keratoacanthoma, lichen sclerosus (et atrophicus), mycosis fungoides, atopic dermatitis, epidermolysis bullosa, extramammary Paget’s disease, malignant melanoma, psoriasis, and secondary neoplasms associated with nevus sebaceous.
    Keywords: extramammary Paget’s disease ; dermcidin ; prognosis ; lymph node metastasis ; survival ; mechanical intermittent compression ; malignant melanoma ; in vitro model ; cancer progression ; mycosis fungoides ; early stage ; diagnostic algorithm ; T-cell receptor rearrangement ; tumor-specific marker ; microRNA ; keratoacanthoma ; squamous cell carcinoma (SCC) ; keratoacanthoma-like SCC ; keratoacanthoma with malignant transformation ; crateriform neoplasms ; crateriform verruca ; crateriform seborrheic keratosis ; crateriform Bowen disease ; crateriform SCC arising from actinic keratosis ; crater form of infundibular SCC ; psoriasis ; STAT3 ; cancer ; immunohistochemistry ; atopic dermatitis ; biologic agents ; neuroimmune interactions ; type 2 inflammation ; PSORS1C3 ; PSORS1C1/CDSN ; LOC105375015 ; rs1062470 ; rs887466 ; rs10484554 ; single-nucleotide polymorphism ; epidermolysis bullosa ; mutation ; heterogeneity ; nevus sebaceus ; malignant tumor ; basal cell carcinoma ; sebaceus carcinoma ; lichen sclerosus ; extracellular matrix protein 1 ; lipoid proteinosis ; basement membrane zone ; laminin-332 ; collagen IV ; collagen VII ; glycosaminoglycan ; n/a ; bic Book Industry Communication::M Medicine
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  • 156
    Publication Date: 2023-10-05
    Description: This study draws lessons regarding technological countermeasures to radioactive contamination caused by the Fukushima Dai-Ichi nuclear power plant accident. It focuses on contamination measurement, efforts to limit dispersal, decontamination, and storage of radioactive materials. The report analyzes technological successes and identifies capability gaps that could be redressed through novel technologies or improved use of existing technologies.
    Keywords: Business ; History ; Sociology ; Technology ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KNB Energy industries & utilities ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFC Social impact of disasters ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 157
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: “Soft Computing and Machine Learning in Dam Engineering” is a comprehensive, edited Special Issue that explores the latest advances in the application of soft computing and machine learning techniques to dam engineering. This reprint covers a range of topics, including dam design, construction, monitoring, and maintenance, and provides readers with a deep understanding of the theoretical foundations and practical applications of these techniques.Featuring contributions from leading experts in the field, the reprint presents a collection of 11 papers that offer insights into state-of-the-art approaches in dam engineering. The chapters cover topics such as fuzzy logic, genetic algorithms, artificial neural networks, and support vector machines, and provide practical examples of how these techniques can be applied to solve real-world dam engineering problems.Whether you are a researcher, engineer, or student in the field of dam engineering, “Soft Computing and Machine Learning in Dam Engineering” provides a valuable resource for staying up-to-date with the latest techniques and approaches in the field.
    Keywords: dams ; Polynomial Chaos Expansion ; random fields ; random forest ; vibration analysis ; gravity dams ; safety assessment ; probabilistic analysis ; parameter uncertainty ; sample optimization ; variance-based sensitivity analysis ; sensitivity analysis ; polynomial chaos expansion ; uncertainty ; deep neural networks ; rockfill dams ; anomaly detection ; machine learning ; support vector machines ; one-class classification ; concrete dam ; machine learning methods ; structural behaviour ; model validation ; ice loads ; concrete dams ; back-calculation ; dam safety ; monitoring ; arch dams ; seismic safety ; endurance time analysis ; non-linear seismic analysis ; concrete damage model ; tensile and compressive damage ; design variable ; finite element ; feasibility design ; surrogate ; AutoML ; roller compacted concrete (RCC) ; risk-informed design ; Cascadia subduction zone (CSZ) ; non-linear structural analysis ; multilayer perceptron neural network model ; structural health monitoring ; threshold definition ; moving average of the residuals ; moving standard deviation of the residuals ; DBSCAN ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 158
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: With the continuous advancement of coastal, offshore, and deep-sea engineering construction (e.g. marine oil, gas, and mineral resource development, offshore wind power projects), associated studies on marine geological environments and hazards have also advanced in parallel. This reprint“Advances in Marine Engineering: Geological Environment and Hazards” is formed by a Special Issue (SI) that was organized by Prof. Xiaolei Liu from the Ocean University of China, Prof. Thorsten Stoesser from the University College London, and Dr. Xingsen Guo from the University College London to document research advances in the topics of marine engineering, including marine geological environments, marine geological hazards, marine engineering geology, marine hydrodynamics, marine fluid mechanics, and marine geotechnical engineering. The high-quality papers collected in this book involve many classic and innovative methodologies in this research field, including but not limited to analytical and statistical analyses, numerical simulations, laboratory testing, and marine surveys. The book represents the state-of-the-art in the latest research concepts, advanced methods, and data that will contribute greatly to the development of the field of marine geological environments and hazards.
    Keywords: gas-hydrate-bearing sediments ; mechanical behavior ; dynamic loading ; discrete element simulation ; macro-meso ; South China Sea ; submarine soft soil ; triaxial test ; mechanical properties ; normalized behavior ; CO2 hydrate slurry ; rheology ; shear-thickening ; Herschel–Bulkley-type model ; sediment acoustic ; frequency dependence ; sound speed ; attenuation ; Biot–Stoll model ; seafloor sediments ; XGBoost ; the East China Sea ; groundwater ; hydrochemistry ; Guangdong coastal zone ; seawater intrusion ; nitrate pollution ; undrained shear strength ; clay samples ; mini-ball penetration test ; low temperature ; strength of bound water ; viscosity of free water ; seafloor bedform ; multibeam bathymetry ; sub-bottom profile ; bottom current ; laterally loaded piles ; initial stiffness ; undrained clay slope ; nonlinear formulations ; finite-element analysis ; cyclic shear test ; silt–steel interface ; stress–displacement mechanical properties ; submarine landslide ; in-situ investigation ; physical modelling ; numerical simulation ; calcareous sand ; cyclic load ; cumulative axial strain ; stiffness ; damping ratio ; deep-buried tunnel ; analytical solution ; anisotropic flow ; conformal mapping ; seepage field ; gas hydrate ; high-resolution seismic ; ultra-high-energy plasma source ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 159
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: Polypharmacy is a necessary and important aspect of drug treatment; however, it becomes a challenge when the medication risks outweigh the benefits for an individual patient. Drug–drug interactions and the introduction of prescribing cascades are common features of polypharmacy, which can lead to ineffectiveness and increased risk of adverse drug reactions (ADR). Genes encoding CYP450 isozymes and other drug-related biomarkers have attracted considerable attention as targets for pharmacogenetic (PGx) testing due to their impact on drug metabolism and response. This Special Issue is devoted to explore the status and initiatives taken to circumvent ineffectiveness and to improve medication safety for polypharmacy patients. Specific areas include drug–drug interactions and consequences thereof in therapeutic management, including PK- and PD-profiling; the application of PGx-based guidance and/or decision tools for drug–gene and drug–drug gene interactions; medication reviews; development and application of deprescribing tools; and drivers and barriers to overcome for successful implementation in the healthcare system.
    Keywords: acute kidney injury ; early biomarker ; plasma neutrophil gelatinase-associated lipocalin ; soluble urokinase plasminogen activator receptor ; medication optimization ; older patients ; emergency department ; multimorbidity ; polypharmacy ; potentially inappropriate medication use ; older adults ; prevalence ; determinants ; chronic ; outpatient ; 2019 Beers criteria ; Ethiopia ; pharmacogenomics ; persons with diabetes ; drug–drug interactions ; drug–gene interactions ; cytochrome P450 ; SLCO1B1 ; drug interaction checkers ; adverse drug reactions ; pharmacogenetics ; personalized medicine ; phenprocoumon ; DOACs ; bleeding ; thromboembolism ; HLA ; drug hypersensitivity ; abacavir ; allopurinol ; flucloxacillin ; antiepileptic drugs ; cost-effectiveness ; shared medication record ; medication reconciliation ; drug information service ; hospital pharmacy service ; electronic prescribing ; electronic medical record ; clinical pharmacist ; CYP2D6 ; CYP2D7P ; CYP2D8P ; copy number variation ; CNV ; genotyping ; 5’nuclease assay ; HRM ; high resolution melting ; drug metabolization ; extracellular vesicles ; exosomes ; microvesicles ; pharmacogene expression ; medication review ; deprescriptions ; quality of life ; aged ; 80 and over ; nursing homes ; deprescribing ; medication-based risk score ; health outcomes ; cytochromes ; CYP1A2 ; adverse drug reaction ; antipsychotics ; olanzapine ; clozapine ; loxapine ; children ; youth ; digital decision-support ; health services research ; general practice ; process evaluation ; antidepressants ; utility ; population-based ; appropriateness ; medication adherence ; digital health ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 160
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This reprint focuses on fish otoliths, as one of the most useful and important biological structures for fishery scientists and managers around the world. Collected papers cover several different research areas, from the otolith macro- to the microstructure and microchemistry, analyzing different types of otoliths and investigating various freshwater and marine species in their larval, juvenile and adult stages. Special attention is given to different approaches in otolith research and to many practical applications of such studies. The obtained data served to determine the age and growth of individual fish; to study habitat interactions, migration patterns, or habitats that the fish live in; to detect water temperatures or the presence of certain pollutants in the environment; and to reveal all other vital information about the life history of the fish.
    Keywords: sagittal otolith ; somatic growth ; long-lived fishes ; ontogeny ; teleost anatomy ; development ; fish morphology ; Fourier ; marking ; alizarin complexone ; hard tissue ; fin ray ; otolith ; scale ; silver carp (Hypophthalmichthys molitrix) ; age ; growth ; otoliths ; morphometry ; Sphyraena sphyraena ; fish age determination ; Greenland halibut ; deep learning ; dataset shift ; domain adaptation ; red snapper ; wavelet ; genetic diversity ; population structure ; asteriscus ; side effect ; otolith shape ; geographical effect ; temperature effect ; pH ; brook trout ; fish kill ; anadromy ; otolith microchemistry ; crucian carp ; strontium ; marking efficiency ; restocking ; time delay ; fish otoliths ; CNN ; age determination ; web tool ; Kokanee ; homing ; stocking ; Anguilla anguilla ; fish biology ; ecosystem variability ; minho river ; stock assessment ; Coilia nasus ; river estuary ; Yellow Sea ; elemental signature ; stable isotopic signature ; stock spatial structure ; atherinids ; trade-off ; daily growth ; spawning ; European hake ; length–frequency distribution ; sex-ratio ; hydro-morpho-sedimentary characteristics ; marginal increment analysis ; band deposition ; Thunnus thynnus ; growth curves ; edge analysis ; growth performance index ; quartile of marginal growth band method ; k-fold cross-validation ; back-calculation ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 161
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This book discusses the manifold applications of several non-destructive methods to a few classes of materials. In particular, X-ray imaging techniques (both in the laboratory and at synchrotron radiation sources) as well Eddy current and magnetic methods are used in a few example materials (metals, concrete and others) to assess the quality of large components and these techniques' suitability as materials characterization tools. Advanced non-destructive evaluation techniques, such as neutron and synchrotron X-ray diffraction, only available at large-scale installations, are also shown to yield particularly relevant information about the residual stress of additively manufactured materials and components. Such large-scale techniques complement laboratory tools well in accessing all the scales of application from micro-level to conventional non-destructive techniques.
    Keywords: micro-scale ; X-ray imaging ; characterization ; metrology ; components ; micro-parts ; quality ; eddy currents ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 162
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Advanced ceramics are referred to in various parts of the world as technical ceramics, high-tech ceramics, and high-performance ceramics. Advanced ceramics have better performances in quality as well as new applications that traditional ones do not have. They have multiple physical and mechanical properties including high hardness, high strength, thermal shock resistance, wear resistance, corrosion resistance, and high-temperature resistance. In view of these characteristics, advanced ceramics are often high value-added products. Developments in advanced ceramics continue at a rapid pace, constituting what can be considered a revolution in the kind of materials and properties obtained.This reprint is intended for material researchers and application developers who seek information on the microstructural design and processing control of advanced ceramics, including piezoelectric ceramics, high-temperature ceramic composites, ceramic coatings, metal glasses, etc.
    Keywords: Aurivillius phase ceramic ; Bi3TiNbO9 ; electrical conduction behaviors ; impedance spectrum ; electrical modulus ; composite ceramic fibers ; boron nitride ; silicon nitride ; SrBi4Ti4O15 ; high-temperature piezoceramics ; oxide additives ; curie temperature ; piezoelectric coefficient ; ion substitution ; Al2TiO5 ; ceramics ; crystal structure ; residual stresses ; neutron diffraction ; Ti3SiC2-PbO-Ag composites ; tribo-chemical reaction ; self-lubricating composite ; tribo-oxidation ; photodeposition ; electron escape ; semiconductor photocatalyst ; MAX phase ; SPS ; Ti3SiC2/Cu composites ; sintering characteristic ; ferroelectrics ; BiFeO3 ; humidity response ; sol–gel preparation ; CaBi4Ti4O15 ; ion doping ; electrical conduction ; dielectric relaxation ; oxygen vacancies ; BMGs ; microstructural inhomogeneity ; tribological behaviors ; HRRF ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 163
    Publication Date: 2023-10-05
    Description: U.S. communities depend on reliable, safe, and secure rail systems. Each weekday, more than 12 million passengers take to U.S. railways. This book explains a framework for security planners and policymakers to guide cost-effective rail-security planning, specifically for the risk of terrorism. Risk is a function of threat, vulnerability, and consequences. This book focuses on addressing vulnerabilities and limiting consequences.
    Keywords: Political Science ; Transportation Studies ; Technology ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPW Political activism::JPWL Terrorism, armed struggle ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::W Lifestyle, sport & leisure::WG Transport: general interest
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  • 164
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Acoustic sensors have an extremely wide range of applications in many fields, including underwater acoustics, architectural acoustics, engineering acoustics, physical acoustics, environmental acoustics, psychoacoustics, and so on. The signals collected by high-sensitivity acoustic sensors contain a large amount of valid information that facilitates further processing of the collected acoustic signals. In particular, detection and feature extraction, as two important measures of acoustic sensor signal processing, can capture more information regarding the target and extract features with separability.
    Keywords: Scholte wave detection ; multilayer elastic bottom ; acoustic pressure field ; source depth ; propagation distance ; feature extraction ; target recognition ; neural networks ; underwater acoustic signals ; acoustic ranging ; acoustic thermometry ; digital lock-in filtering ; electrical conduit ; time-of-flight estimation ; delay estimation ; singular value decomposition ; GCC-PHAT-ργ weighting ; generalized cross-correlation ; SPB method ; sound pass-by ; low-noise surfaces ; noise modeling ; road traffic noise ; unattended noise measurement procedure ; traffic measurements ; noise emission ; environmental noise ; sound ; partial updates ; least mean squares ; Leaky LMS ; structural active noise control ; deconvolved beamforming ; fractional Fourier transform ; direction of arrival estimation ; linear frequency modulation signal ; fault diagnosis ; hierarchical slope entropy ; white shark optimizer ; optimized support vector machine ; bearing signals ; metro traction motor bearings ; multisignal fusion ; Markov transition field ; optimized deep residual network ; diagnosis of compound faults ; multistable stochastic resonance ; adaptive parameter ; improved grey wolf algorithm ; bearing fault detection ; state estimation ; unknown statistical characteristics of noise ; cost-reference particle filter ; multi-population cooperation ; intelligent resample ; Gaussian mutation ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: The global financial crisis plunged the global economy into a great recession. Many central banks responded with unconventional monetary policies such as quantitative easing, negative policy rates, and forward guidance to calm down financial markets. The COVID-19 pandemic led the global economy, financial markets, and central banks to face even more severe problems. Central banks set up further asset purchase programmes to complement existing unconventional monetary policy measures that have already been in place to help the economy to absorb the COVID-19 shock. The new crisis has increased the importance of preserving financial stability through the international cooperation of central banks around the globe. Managing the expectations of market participants plays a crucial role in the context of financial stability. Therefore, the aim of this Special Issue is to disseminate important empirical and theoretical research questions concerning the connection between monetary policy and international financial markets and to stimulate discussion among academics and policymakers. A special focus is devoted to emerging and developing economies. The Special Issue covers several different articles on a variety of topics from the fields of monetary policy and international financial markets. The contributions address research questions on exchange rates, cryptocurrencies, stock markets, the connection between money supply and inflation after the COVID-19 pandemic, the role of commodity price shocks for banking system stability in developing countries, global liquidity effects, the twin deficit, and the Taylor rule.
    Keywords: exchange rates ; cryptocurrencies ; inflation ; COVID-19 ; commodity prices ; emerging and developing countries ; stock markets ; banking ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 166
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Laser-based additive manufacturing (LAM) is a revolutionary advanced digital manufacturing technology developed in recent decades, which is also a key strategic technology for technological innovation and industrial sustainability. This technology unlocks the design and constraints of traditional manufacturing and meets the needs of complex geometry fabrication and high-performance part fabrication. A deeper understanding of the design, materials, processes, structures, properties and applications is desired to produce novel functional devices, as well as defect-free structurally sound and reliable LAM parts.The topics in this Special Issue reprint include macro- and micro-scale additive manufacturing with lasers, such as structure/material design, fabrication, modeling and simulation, in situ characterization of additive manufacturing processes and ex situ materials characterization and performance, with an overview that covers various applications in aerospace, biomedicine, optics and energy.In this Special Issue reprint, papers on different subjects were published after the high-quality reviewing process, with a total of 17 contributions (1 editorial, 2 review papers and 14 original research papers) and times viewed being over 13K (as of Nov 15 2022). Six articles were selected as Editor’s Choice, and one article was selected as the Issue Cover (Volume 13, Issue 8).
    Keywords: Mg-Zn solid solution ; laser sintering ; mechanical alloying ; corrosion resistance ; directed energy deposition ; additive manufacturing ; bimetal ; analytical model ; printability maps ; femtosecond laser ; hyaluronic acid methacryloyl ; polyethylene glycol diacrylate ; stimuli-responsiveness ; selective laser melting ; laser powder bed fusion ; Ti–6Al–4V ; heat treatment ; annealing ; laser cutting ; non-contact process ; neutron tube shells ; 304 stainless steel ; fiber laser ; thermal transmission simulation ; Ti-6Al-4V ; dynamic behaviors ; porosity ; spall ; NiTi alloy ; CuSn10 alloy ; dissimilar materials ; interfacial bonding properties ; laser material deposition ; pulse wave laser ; temperature field simulation ; surface quality ; microstructural features ; corrosion behavior ; laser melting injection ; W particles ; Al alloys ; wear ; iron bone implant ; zinc sulfide ; degradation properties ; passivation film ; thermal management materials ; titanium-coated diamond/copper composites ; copper-coated diamond/copper composites ; selective laser sintering ; carbon fiber reinforced polyamide composites ; strain rate ; hygroscopicity ; additively manufacture ; 17-4PH stainless steel ; laser additive manufacturing ; Poisson’s ratio ; anti-tetrachiral stents ; biocompatibility ; spatter ; in situ detection ; generation mechanism ; detrimental effects ; counter-measures ; compression ; microstructure transformation ; dislocation pinning ; recovery ability ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: The research scope of this reprint mainly focuses on GNSS data processing methods; GNSS applications; precise GNSS positioning and navigation; theories, models, and methods for processing wojGNSS errors; multi-GNSS positioning technologies; positioning and navigation methods under challenging environments; and low-cost GNSS positioning and navigation.
    Keywords: relative positioning ; GPS/BDS ; multi-baseline solution ; deformation monitoring ; positioning and navigation ; indoor positioning ; Beacons selection ; signal anomaly detection ; BeiDou-3 Navigation Satellite System ; real-time clock offset ; PPP-B2b service ; BDS-3 ; clock offsets estimated ; inter-satellite links ; two-way satellite time and frequency transfer ; GNSS ; independent baseline ; GNSS network solution ; observation-max ; shortest ; observation density ; minimum spanning tree ; high-rate GNSS ; structural health monitoring ; PPP ; PPP-AR ; RTK ; BDS-3 new signals ; RT-PPP ; single-/dual-frequency RT-PPP ; ASV-PWV model ; radiosonde ; ERA5 ; Qinghai Tibet Plateau ; real-time Precise Point Positioning (RT-PPP) ; Inertial Navigation Pystem (INS) ; odometer ; tightly coupled integration ; BDS ; B1I/B3I frequencies ; B1C/B2a frequencies ; iGMAS ; precise orbits ; GPS ; Galileo ; single point positioning (SPP) ; positioning performance ; GNSS/INS sensors ; Smartphone Xiaomi Mi8 ; kinematic-trajectory acquisition ; u-blox ZED-F9P and ZED-F9R ; mobile mapping system (MMS) ; Android ; multi-GNSS ; real-time kinematic (RTK) positioning ; receiver channel-dependent bias ; differential inter-system bias (DISB) ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: The objective of this book is to publish the most recent technological advancements, and theoretical and practical research outcomes, alongside high-quality literature reviews on wireless power transfer to charge electric vehicles. More substantial research is proposed due to the fast-growing market for electric vehicles, and recent advances in wireless power transfer techniques have the potential to make this technology available for all consumers by overcoming its drawbacks. For instance, one of the major downsides to EVs is the requirement for an automobile to be idle during charging times. This problem can be solved by implementing dynamic wireless power transfer (WPT) with a higher power transfer efficiency (PTE). So, this book endeavors to create a major forum for investigating recent advances and the envisioned future in wireless power transfer for electric vehicles in terms of modeling, design, performance, operation, control, implementation, storage, electric machines, power electronics converters, optimization, cost, charging techniques, and applications. This book provides valuable contributions to the field of electric vehicles: inductive power transfer concepts; airport inductive charging infrastructures; the design of a wireless charging system for an e-bike with grid connection; control of renewables; social, economic, political, and technical factors for dynamic wireless charging; the influence of posture and coil position on the safety of a WPT; double-coil dynamic shielding technology for WPT; reduction in cogging torque in a PM brushless DC motor; and optimal dynamic scheduling of EVs in a parking lot.
    Keywords: charging cost ; dynamic charging ; economics ; electric vehicles ; optimization ; parking lots ; static charging ; PMBLDC motor ; cogging torque ; finite element analysis ; virtual work method ; shifting angle ; electromagnetic field ; wireless power transfer ; shielding ; electric vehicle ; EMF safety ; numerical dosimetry ; wireless charging ; dynamic wireless power transfer ; EV charging infrastructure ; stakeholder engagement ; electric road systems ; system demand ; APF ; power quality ; SRF ; UPC ; VAR ; brushless doubly fed reluctance generator (BDFRG) ; crowbar ; symmetrical fault ; unsymmetrical fault ; wind turbine (WT) ; inductive power transfer ; e-bikes ; forward converter ; dynamic wireless charging ; airport apron ; airport infrastructure planning ; electric busses ; charging automation ; electric vehicles (EVs) ; wireless power transfer (WPT) ; production ; automation ; inductive power transfer (IPT) ; manufacturing ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This reprint brings together fifteen articles published in the Special Issue of the journal Atmosphere, entitled “High-Performance Computing Serving Atmospheric Transport & Dispersion Modelling”. These articles cover a wide variety of topics related to air quality in urban areas and nature-based solutions to improve it in the context of climate change; impact studies on human health and the environment of facilities and infrastructure projects as well as risk studies; the assessment of emerging threats; and preparations for and responses to emergencies involving toxic, flammable, or explosive atmospheric releases. As the fifteen articles presented here remarkably illustrate, what these contemporary topics have in common is the implementation of multi-scale simulations of atmospheric transport and dispersion by means of physical models of computational fluid dynamics (CFDs), whose potential is enhanced by high-performance computing (HPC). This reprint thus addresses the answers provided by modelling and the most advanced simulations to some societal matters of major interest.
    Keywords: operational emergency modeling ; atmospheric release ; high-resolution metric grid ; 3D ; PMSS modeling system ; Code_Saturne ; EMERGENCIES project ; lattice Boltzmann method ; large eddy simulation ; pollutant dispersion ; urban physics ; urban air pollution ; nature-based solutions ; green infrastructure ; PMSS Lagrangian model ; NOx ; PM10 ; large-eddy simulation ; plume dispersion ; urban area ; coupling simulation ; mesoscale meteorological simulation model ; meteorological observation ; graphics processing unit computing ; atmospheric dispersion modelling ; microscale dispersion ; model validation ; database ; on-site meteorological observation ; water mist dispersion ; lagrangian dispersion model ; web visualization ; web mapping ; emergencies project ; atmospheric boundary layer ; OpenFOAM ; gas dispersion ; CFD ; turbulence model ; hazard assessment ; horizontal homogeneity ; wind field ; deposition ; machine learning ; hazardous release ; WRF ; FLEXPART ; prediction ; air pollution ; air quality modelling ; ADMS-Urban ; high performance computing ; HPC ; West Midlands ; air quality ; urban scale ; traffic emissions ; micro-scale dispersion models ; aerosols ; South Asia ; WRF-Chem ; precipitation ; CAPE ; CIN ; urban dispersion ; complex terrain ; fast-response dispersion modeling ; computational fluid dynamics ; RANS ; urban dispersion modelling ; Reynolds-averaged Navier–Stokes ; situational awareness ; CityGML ; air quality impact study ; PMSS model ; high resolution grid ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: Streams and rivers are subject to considerable hydrodynamic loads. Flow interactions with natural or man-made structures in open channels lead to the development of complex dynamic processes, requiring further studies to comprehend fully. This Special Issue has been conceived to facilitate improvement or propose new approaches, summarize the most important findings of previous studies, and encourage the development of further knowledge in the field of open-channel flows. Various topics are addressed in this SI, including flow interaction with hydraulic structures, flow dynamics in estuaries, flow-vegetation interactions, bed sediment effects on flow structures, and the effect of channel curvature on flow behaviors and sediment transport. The studies published in this Special Issue certainly help readers understand the turbulent flow involved in open channels and apply that understanding to the design and practice of hydraulic engineering and river management.
    Keywords: sinuous channel ; velocity fluctuations ; river bend erosion ; structure function ; debris flows ; flow velocity ; sediment concentration ; prevision ; river hydraulics ; vegetation ; flow resistance ; turbulence ; numerical methods ; scour ; equilibrium condition ; velocity field ; secondary currents ; acoustic Doppler velocimeter ; rough bed ; secondary flow ; turbulent bursting ; turbulence kinetic energy ; friction coefficient ; open-channel flow ; entropy ; Reynolds number ; rigid vegetation ; bed roughness ; turbulent flow ; Turbulent Kinetic Energy (TKE) ; energy spectra ; bridge scour ; empirical formulae ; riprap sloping structure ; flow contraction ; overtopping flow ; stochastic analysis ; forecasting ; extreme events ; solitary wave ; turbulent coherent structures ; length scales ; wavelet transform ; turbulent velocity ; transport mechanism ; tidal range ; suspended sediment flux ; Oued Sebou estuary ; bathymetry ; dredging ; SWAN ; wave spreading ; flow hydrodynamic structures ; lateral deflectors ; gentle-slope tunnel ; water-wing ; shock wave ; energy dissipation ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The reprint provides the most relevant and state-of-the-art in the field, including recent developments in the production of natural compounds from various bioresources, and their formulations as bioactives. This reprint also covered the engineered approaches for enhanced biological properties and their potential applications. Identification of novel compounds and bioprocess tools to improve the quantity and quality of bioactive compounds and their formulations are exclusively covered in this reprint.
    Keywords: anti-solvent ; enzymatic saccharification ; EMIM-Ac ; ethanol ; ionic liquid ; lignocellulosic biomass ; recycling ; agro-industry ; microencapsulation ; bioactive compounds ; in vitro digestion ; yogurt ; cannabis ; cannabinoids ; postharvest ; drying ; curing ; storage ; biosynthesis ; pre-treatments ; sorption isotherm ; Raphanus sativus L. ; recombinant IFN-α2a ; apoptosis ; antiviral and antitumor activity ; Japanese knotweed rhizome bark ; SARS-CoV-2 ; COVID-19 ; virus neutralization test ; nano-formulation ; nutraceuticals ; prebiotics ; nanofabricated delivery system ; liposomes ; nano-emulsions ; Abelmoschus manihot ; neurodegenerative disease ; oxidative stress ; proliferation ; inflammation ; nucleotide excision repair ; Actinosynnema pretiosum ; ansamitocin P-3 ; ssgA ; AdpA ; morphological differentiation ; pomegranate ; pomace ; extraction ; biological activity ; functional beverages ; sensory quality ; vitamins ; formulation ; homogeneous systems ; hydrophile–lipophile balance ; Emblica officinalis ; phytochemicals ; hyperlipidemia ; pharmacology ; nanoformulation ; Prunus mume ; vasorelaxant ; hypertension ; angiotensin receptor blockers ; agro-waste ; valorization ; value-added bioproducts ; micro/nano encapsulation ; agri-food-pharma applications ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: Mangrove communities represent a coastal habitat located in the intertidal zone or brackish water of tropical and subtropical coastal areas, between 5°N and 5°S latitudes, spanning over 118 countries. The special ecological conditions of mangroves include high salinity, nutrient limitation, tidal gradients, high temperatures, excessively high light, and muddy anaerobic or sandy soil, which lead to various morphological and physiological adaptations of inhabiting species and act as an effective selector for the metabolic pathway via the generation of unique functional metabolites with highly unique chemical scaffolds and pharmaceutical application potential. In recent decades, numerous metabolites with uncommon structures and efficacious bioactivities have been discovered in mangrove-derived microorganisms, along with mangrove plants. For this reason, mangrove ecosystems have taken the limelight as an attractive biodiversity hotspot, attracting significant attention from organic chemists and pharmacologists. Additionally, many unique and novel chemical structures with a wide range of structural classes have suggested various biosynthetic origins containing novel functional genes and corresponding enzymes with unique catalytic functions. In this Special Issue, we welcome articles describing recent studies and pertinent reviews focusing on the latest and most important developments in bioactive product discovery from mangrove ecosystems and correlating structures with chemical synthesis, biosynthesis, genomic and metabolomics approaches, biological activities, and pharmaceutical mechanisms. We are now in the process of putting together a group of top researchers whose work we would like to feature in this collection, and we would like you to participate.
    Keywords: mangrove ecosystems ; bio-active products ; signaling pathway ; chemical synthesis and biosynthesis ; genomic and metabolomics approaches ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: The world has never been richer than today. The distribution of our global wealth, however, is hugely biased. Since 1980, the gains were mainly captured by the rich: The top 1% obtained twice as much of the income growth as compared to the bottom 50%. Nevertheless, within economics, debates about inequality have remained rather marginal, despite long-term research by renowned scholars such as Tony Atkinson. Within the public arena, concerns about inequality emerged as a result of a number of developments: First, the global financial crisis in 2008 exposed the risks of the financing of the economy; secondly, 2013, Thomas Picketty’s book “Capital in the 21st century” demonstrated that, against the trend of the overall 20th century, capital returns outstrip the gains through economic growth in recent decades, thus threatening social coherence and democratic institutions and thirdly, the Millennium Campaign presented impressive achievements regarding poverty but stirred doubts whether the most deprived were left even further behind. Since 2015, then, the stated aim of SDG 10 is to “reduce inequality within and among countries”. There is growing consensus that economic growth is not sufficient to reduce poverty, and that our efforts to make it more inclusive so far were insufficient. The very first step reduce inequality is to adopt a systemic perspective, allowing an integrative analysis covering both ends of the ladder. Policies should be universal in principle and pay attention to the needs of disadvantaged and marginalized populations. Predicated on comparison, inequality reminds us that it’s not enough to study lower earners and the poor. Instead, the term demands that we expand our perspective, scrutinizing how economic value is generated, accumulated, at whose cost, and – not least – how the overall system could be made fairer. “Transitioning to Reduced Inequalities” therefore explores inequality trends worldwide, offers a debate on different measures and comparative perspectives, highlights key actors who either benefited or suffered from recent economic trends, and explores policy options to reduce inequality and thus contribute to SDG 10. The volume considers particularly: conceptual frameworks with regards to the inequality debate; the relationship between poverty reduction, economic growth and inequality; measures of inequality; overlooked/bypassed groups in developing countries; analysis on income/wealth growth for different groups in the global north; discussion about policies to reduce inequality; and further research in the realm of inequality. Transitioning to Reduced Inequalities is part of MDPI's new Open Access book series Transitioning to Sustainability. With this series, MDPI pursues environmentally and socially relevant research which contributes to efforts toward a sustainable world.
    Keywords: poverty ; inequality reduction ; equality ; economic development ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: This Special Issue in Cancers is focused on cell therapy, bispecific antibodies, and other immunotherapies against cancer. It includes reports on cell therapies such as CAR-NK cell therapies, and bispecific antibodies against multiple myeloma and B cell lymphoma. Immunotherapies against solid tumors include TGF-beta-PDL-1 fusion protein and EpCAM-CD3 bispecific antibody generated with mRNA-lipid nanoparticles (LNP) against colorectal tumors. The clinical studies ongoing with bi- and tri-specific T cell engager antibodies against solid tumors and advantages versus cell therapies are discussed. This Special Issue highlights novel approaches to cell therapies, bispecific antibodies, vaccines, and immunotherapies that will be interesting for cancer cell researchers, biologists, and oncologists.
    Keywords: cell therapy ; bispecific antibody ; chimeric antigen receptor ; cancer ; immunotherapy ; vaccine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: This reprint is a collection of the peer-reviewed papers published in the Special Issue “Surface engineering & coatings technologies for corrosion and tribocorrosion resistance" in the Materials journal. The Special Issue reprint aims to bring together the latest developments in this technologically, economically, and environmentally important area. It provides a forum for researchers to share their original work or insight reviews in this field.
    Keywords: advanced high-strength steel ; phosphate coating ; acid cleaning ; electrochemical impedance spectroscopy ; electro spark deposition (ESD) ; Mo coating ; H13 steel ; microhardness ; wear resistance ; corrosion resistance ; polymer derived ceramics ; coatings ; fillers ; stainless steel ; hydrothermal corrosion ; n/a ; tribocorrosion ; abrasive wear ; hot-forming process ; boron steel ; heat treatment ; hot-dip zinc galvanizing ; coating hardness ; plasma immersion ion implantation ; niobium ; bipolar plate ; metals ; electrophoretic deposition (EPD) ; cataphoretic (CPD) and anaphoretic deposition (APD) ; inhibited formulations (INFOR) ; organosilanes ; corrosion inhibitors ; metal corrosion ; anti-corrosion inhibitor ; polymeric inhibitor ; adsorption ; titanium alloys ; plasma nitriding ; TEM ; HRTEM ; galvanized steel ; adhesive bonding ; interfacial interaction ; molecular dynamics (MD) ; density functional theory (DFT) ; laser shock processing ; aeronautical components ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This second Special Issue was compiled because of the interest demonstrated by the great success of the first Special Issue devoted to "Sensor Systems for Gesture Recognition".We believe this reprint acts as a meaningful window towards "Gesture Recognition" and the related sensors allowing the gathering of necessary data.
    Keywords: abnormal gait behavior ; OpenPose ; machine learning ; XGBoost ; random forest ; horse locomotion ; training effect ; inertial measurement units ; sports technology ; football ; motion analysis ; IMU ; trajectory reconstruction ; human-computer interactive ; data glove ; virtual hand ; emotion driven ; test ; visual tracking ; Siamese tracker ; tracking drift ; background clutter ; deep learning ; surgical skills assessment ; computer vision ; surgical education ; biomedical engineering ; multi-modal ; human activity recognition ; markerless ; RGB-D ; general movements ; infant movement analysis ; movement disorders ; surface electromyography ; forearm amputee ; hand posture ; visual feedback training ; pattern recognition ; artificial neural network ; hand gesture recognition ; electromyography ; inertial measurement unit ; reinforcement learning ; deep Q-network ; extreme learning machine ; force myography ; grasshopper optimization algorithm ; k-tournament selection ; frequency emphasis ; ensemble learning ; sign language recognition ; gloss prediction ; transformer ; pose-based approach ; pose estimation ; emotion judgment system ; adaptive interactive game ; set of optimal signal features ; sensor ; MARG ; MIMU ; orientation estimation ; sensor fusion algorithm ; dataset ; orientation algorithm benchmarking ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    Radboud University Press
    Publication Date: 2023-11-17
    Description: In his professional journey, travelling through an upcoming field of surgery with apparently unlimited possibilities, Kees van Laarhoven witnessed major milestones and breakthroughs. Already as a medical student, he was amazed by surgical courage. During residency, he experienced hard work, diligence and perseverance of surgical professionals. Today as a surgeon with over 25 years of clinical experience he now looks at pieces of art in surgery with professionals compassionately bringing hope to patients.But he also sees inconvenient truths in our healthcare system, with patients evolving from one predictable and preventable disease to the next and with professionals following disease trends rather than applying their knowledge to redirect disease into health. The modern disease-oriented care system becomes undesirable and unsustainable. And there are more inconvenient truths that have progressed rather than diminished in time. Healthcare is not easily accessible to the major half of the global population and for those who have access, with a growing global population, healthcare may become unaffordable in the future. Moreover, from an environmental perspective, both human and planetary health are compromised and ask for a ‘One Health’ approach. Being fascinated by the questions of how and why did this all happen, Kees van Laarhoven took up a scientific survey to comprehend and learn how things still can be changed. He found that clear solutions are there! Please join him on his journey.
    Keywords: Global population overgrowth; Economic drivers of disease; Environmental drivers of disease; Prevention and integrative health; One health; Human and planetary health ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCQ Health economics ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services ; bic Book Industry Communication::V Health & personal development ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: The Special Issue constitutes the collection of the selected papers, which results were presented during the XVIII Conference on Automation, Operation and Maintenance of Control and Communication Systems ASMOR 2022. The conference took place in Władysławowo (Poland) on 12-14 October 2022. The scope of the conference was mainly focused on automation and exploitation aspects of the control and communications systems. In order to meet the highest quality standards for published papers, only the articles selected by the ASMOR Scientific Committee and the Electronics Editors were qualified for an extensive reviewing process.
    Keywords: NIR DLP spectroscopy ; reflectance time-non-stable spectra ; artificial neural network ; SLAM ; 3D mapping ; mobile robot ; underground inspection ; evolutionary neural networks ; hill climb ; control ; classification ; collision avoidance ; path planning ; obstacle detection ; autonomous underwater vehicle ; artificial intelligence ; autonomous navigation ; autonomous navigation system ; maneuver auto-negotiation ; multi-agent system ; obstacle avoidance ; real-time path planning ; unmanned surface vehicle ; LTE ; NB-IoT ; reception quality indicators ; data concentrator ; robotic deburring ; machining ; machining parameters ; pneumatic tools ; industrial robots ; optical scanner ; programming ; neural decision-making system ; communication ; robot ; laser tracker ; design of robotic system ; measurement in robotics ; signal analyzer ; tune master ; test signal viewer ; robot monitoring ; attitude ; aircraft ; UAV ; fixed-wing ; quaternions ; Euler angles ; avionics ; UWA channel ; impulse response ; underwater communication ; signal propagation ; channel stationarity ; chirp signal ; biomimetic underwater vehicle ; depth controller ; genetic algorithms ; particle swarm optimization ; Pareto optimization ; magnetic launcher ; levitation force ; dynamics modeling ; numerical simulation ; automation of control systems ; operation and maintenance of control systems ; automation of communication systems ; operation and maintenance of communication systems ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: Since the first works introducing the aluminum intercalated clay family in the early 1970s, interest in the synthesis of Pillared InterLayered Clays (PILC) has increased tremendously, especially research into their properties and energetic and environmental applications. After our comprehensive reviews and book on the synthesis and catalytic applications of these materials, new references have appeared in the literature and the interest in this field is continuously increasing. The aim of this Special Issue is to collect the recent advances developed considering this family of solids.
    Keywords: clays ; Al-PILC ; pillared clays ; scale up ; pillaring solution ; Keggin ion ; reutilization ; Keggin polycation ; concentrated media ; microwave radiation ; pillared montmorillonite ; AlNi-PILC ; Pd-Ce ; catalytic combustion ; benzene ; TPD/TPSR ; ZnO-TiO2/delaminated montmorillonite ; heterostructures ; Ag-coating ; solar photocatalytic activity ; water purification ; cadmium ; chitosan ; modification ; 13X molecular sieve ; removal ; dye remediation ; adsorption ; azo dye ; wastewater ; pillared porous phosphate heterostructures ; isotherm ; sericite ; thermal modification ; acid activation ; sodium modification ; montmorillonite/hydrotalcite composite ; montmorillonite/titania composite ; organoclay ; inverse micelle ; Mn-Al mixed oxide ; combustion catalysts ; ciprofloxacin ; smectite ; pillared clay ; keggin-like mixed Al/Fe polyoxocation ; mineralogical composition ; catalytic wet peroxide oxidation ; mesosilica ; methyl orange ; palygorskite ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The replacement of the bridging H atom in H-bonds by a multitude of other, more electronegative, atoms has led to the rapidly growing study of related noncovalent bonds generally known as halogen, chalcogen, and pnicogen bonds. It has recently been recognized that elements of the tetrel family (C, Si, Ge, Sn, Pb) also engage in such bonds, wherein the tetrel atom serves as an electron acceptor to an incoming Lewis base, and that these bonds can be quite strong. This type of bond has the potential to be of importance comparable even to that of the well-researched H-bond, as it may be far more prevalent than has been realized, perhaps a common feature of chemical and biological systems too numerous to mention. The articles included in this volume delve into the many facets of tetrel bonds: the factors determining their strength, their geometrical requirements, various phenomena in which they play an outsized role, and the means by which they can be detected and measured.
    Keywords: noncovalent bond ; carbon bond ; &nbsp ; sigma-hole ; pi-hole ; methyl groups ; spectroscopy ; pnicogen bond ; chalcogen bond ; halogen bond ; anion binding ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 181
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This book reprints articles from the Special Issue "Advances in Computer-Aided Technology" published online in the open-access journal Machines (ISSN 2075-1702). This book consists of thirteen published articles. This Special Issue belongs to the "Mechatronic and Intelligent Machines" section. Industry 4.0 is characterized by the integration of advanced technologies, such as artificial intelligence, the Internet of Things, and cloud computing, into traditional manufacturing and production processes. CAx (Computer-Aided Systems) systems are a set of computer software tools used in engineering and product design, covering various stages of the product development cycle. Advanced CAx tools combine many different aspects of product lifecycle management (PLM), including design, finite element analysis (FEA), manufacturing, production planning and product. In connection with the transition to Industry 4.0 concepts, the concept of the digital twin comes to the fore, and existing CAx systems must adapt to this trend. The Special Issue deals with a number of research areas, such as: - New trends in CAx systems; Digital manufacturing; Internet of Things in manufacturing; Simulation of production systems and processes; Systems for advanced finite element analysis; Material engineering; Digitization and 3D scanning.
    Keywords: tensor glyph ; golden section ; vector space ; sandwich ; springback ; Vegter yield criterion ; numerical simulation ; PAM-STAMP 2G ; isotropic hardening law ; kinematic hardening law ; bending ; Bauschinger effect ; machine learning ; artificial neural network ; additive manufacturing ; high precision metrology ; CAD ; predictive model ; ship hull structure ; computer-aided design of structure ; database ; function soft block ; gun drill tool ; deep-drilling technology ; optimization ; tool life ; angle ; digital implant impression ; interimplant distance ; intraoral scanner ; trueness ; sewing machine ; needle bar ; floating needle ; electromagnet ; electromagnetic simulation ; noise reduction ; cycloidal gearbox ; friction ; actuator ; servomotor ; permanent magnet synchronous machine ; fixture design ; machining ; sustainable manufacturing ; process innovation ; complex-shape part ; signal processing ; monitoring system ; laser profiler ; surface roughness ; quality assessment ; non-contact method ; vision-based method ; frequency analysis ; abrasive water jet ; wood plastic composite ; natural reinforcement ; knitting machine ; stroke ; drive ; simulation ; cylinder ; dynamic modeling ; load spectrum reconstruction ; fatigue test ; hydraulic excavator ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 182
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: The purpose of this Special Issue “The Role of Nutrition in Cardiometabolic Health: Experimental, Clinical, and Community-Based Evidence” is to publish a focused, coherent, impactful, and well-cited volume on how nutrition influences diverse cardiometabolic risk factors. Cardiometabolic diseases, such as coronary heart disease, stroke, type 2 diabetes mellitus, and obesity, is the leading cause of death worldwide. In recent years, dietary habits have shifted all over the globe. At the same time, a constantly growing body of evidence demonstrates the role of caloric intake and dietary composition as determinants of cardiometabolic health. Suboptimal diet predisposes to a myriad of cardiometabolic risk factors such as impaired glucose metabolism, insulin resistance, dyslipidaemias, and high blood pressure.
    Keywords: vitamin D ; obesity ; microvascular ; bariatric surgery ; weight loss ; nitric oxide ; cardiac remodeling ; cardiac dysfunction ; echocardiogram ; obese rats ; high-fat high-sugar diet ; vascular stiffness ; blood pressure ; whey protein isolate ; older adults ; dietary factor ; cardiovascular disease ; umbrella review ; low-carbohydrate diet ; hypocaloric ; isocaloric ; women health ; conduit artery ; microvasculature ; cardiovascular risks ; primary prevention ; homocysteine ; folate ; vitamin B12 ; vascular dysfunction ; hepatocyte ; TGR5 ; glucose regulation ; homocysteine and vascular disease ; H3K27me3 ; epigenetics ; atherosclerosis ; MRI (magnetic resonance imaging) ; liver ; metabolic regulation ; laparoscopic sleeve gastrectomy ; micronutrients ; deficiency ; body mass index ; cardiotonic steroids ; left ventricular mass ; marinobufagenin ; dietary salt intake ; young adults ; bic Book Industry Communication::M Medicine
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  • 183
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: In this Special Issue, we have compiled data and opinions from leading scientists to demonstrate the recent advances in the study of function and dysfunction of synucleins. These proteins are involved in multiple normal and pathological molecular processes and consequently have various effects on cell biology of the nervous system. Three members of the synuclein family share many structural properties and have an overlapping pattern of expression and intracellular distribution in the developing and adult nervous system, which point to functional redundancy within the family. However, each synuclein has its own functions which are not shared with the two other family members, and there are certain cellular mechanisms and pathways in which these functions could be antagonistic rather than synergistic.
    Keywords: prenatal alcohol exposure ; synucleins ; alcohol consumption ; free-choice ; hippocampus ; midbrain ; mRNA expression ; α-synuclein ; rats ; dopaminergic neuron ; MPTP ; knockout mice ; Parkinson’s disease ; alpha-synuclein ; SH-SY5Y ; hiPSCs ; organoid ; aggregation ; synucleinopathy ; blood–brain barrier ; microglia ; astrocytes ; overexpression ; mutation ; Lewy body ; synucleinopathies ; multiple system atrophy ; dementia with Lewy bodies ; deep brain stimulation ; focused ultrasound ; gene therapy ; surgical techniques ; dopamine ; electroencephalogram ; frequency spectrum ; α-, β- and γ-synuclein ; epigenetic ; protein aggregation ; SNARE-complex ; protein trafficking ; phytochemicals ; methylation ; histones ; γ-synuclein ; autoantibodies ; glaucoma ; α2-macroglobulin ; tear fluid ; intraocular pressure ; SARS-CoV-2 spike RBD domain ; amyloid aggregation ; post-COVID-19 neurodegeneration ; SARS-CoV-2 vaccine ; depression ; serotonin ; raphe nuclei ; Lewy bodies diseases ; E46K-SNCA ; cognition ; nonmotor ; clustering analysis ; multimodal MRI ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 184
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: This reprint brings together a group of articles that were published as a Special Issue on prosthetic joint infection in the journal Antibiotics. They cover various aspects of risk factors and prevention, medical and surgical treatment, and outcomes of prosthetic joint infections.
    Keywords: prosthetic joint infection ; arthroplasty infection ; prosthetic joint infection functional outcome ; prosthetic joint infection ambulatory outcome ; tedizolid ; prosthetic joint infections ; prolonged oral treatment ; tolerance ; compliance ; surgical antimicrobial prophylaxis ; knee arthroplasty ; hip arthroplasty ; surgical site infection prevention ; prosthetic joint infection prevention ; intraoperative cultures ; antibiotic levels ; serum bactericidal titer ; oxazolidinones ; osteoarticular infections ; diabetic foot infections ; drug-drug interaction ; Staphylococcus aureus ; implant removal ; outcome ; rifampin ; biofilm ; knee ; total knee arthroplasty ; infection ; intra-articular injection ; surgical site infection ; epidemiology ; risk factors ; multidrug-resistant Gram-negative bacteria ; extensively drug-resistant ; hematoma ; hip hemiarthroplasty ; proximal femur fracture ; antibiotic prophylaxis ; periprosthetic joint infection ; decolonization ; daptomycin ; eosinophilic pneumonia ; Candida spp. ; fungus ; antifungal-loaded cement spacer ; two-stage exchange surgery ; Cutibacterium acnes ; surgical and medical treatment ; dalbavancin ; gram-positive ; sol-gel ; anidulafungin ; Candida albicans ; suppressive antibiotic treatment ; prolonged antibiotic ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine::MBNS Epidemiology & medical statistics
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  • 185
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: Advanced X-by-wire technologies for vehicular electrified chassis play an essential role in the development of new energy intelligent vehicles, which is the inevitable choice for intelligent vehicles in the future. This technology is involved in mechanical engineering, electronic and electrical engineering, computer technology, control engineering, signal processing, and artificial intelligence. Advanced electrified chassis control technology transmits control signals through cables and acts directly on the actuator to implement corresponding actions. The application of X-by-wire technologies for vehicular electrified chassis has changed the complex mechanical connections among actuators and hydraulic and pneumatic equipment in the past, greatly promoting energy efficiency, integration, and intelligence. This reprint focuses on advanced X-by-wire technologies in strong reliability design, modeling, integration control, thermal management, energy management, fault diagnosis, and fault-tolerant control with the vehicular electrified chassis. Therefore, the aim of this reprint was to solicit recent advanced X-by-wire technologies for vehicular electrified chassis.
    Keywords: energy consumption optimization ; torque distribution ; energy efficiency ; motor efficiency ; four in-wheel motor drive electric vehicle ; nonlinear model predictive control ; four-wheel drive ; acceleration slip regulation ; intervention and exit mechanisms ; autonomous driving ; planning algorithm ; variable Gaussian safety field ; reinforcement learning ; policy gradient ; x-by-wire vehicle ; trajectory tracking control ; model predictive control ; hierarchical control ; distributed drive electric vehicles ; additional roll moment ; decoupling control ; load transfer rate ; electronically controlled air suspension ; solenoid valve ; extended Kalman filter bank ; fault diagnosis ; fault-tolerant control ; distributed driving electric vehicles ; polynomial path planning ; torque allocation ; obstacle avoidance path tracking ; fuzzy neural network ; particle swarm algorithm ; PID control ; active suspension ; MATLAB/Simulink simulation ; suspension ; mechatronic inerter ; bridge network ; high-order impedance ; real vehicle test ; autonomous vehicle ; path tracking control ; non-singular fast terminal sliding mode control ; model reference control ; vehicle ; fractional-order electrical network ; structure-immittance approach ; optimal design ; multi-agent coordinated control system ; active collision avoidance ; blackboard model ; real-time ; electric vehicles ; regenerative braking ; energy recovery ; genetic algorithm ; braking stability ; seat suspension ; inerter ; mechatronic system ; permanent magnet synchronous machine (PMSM) ; position sensorless compound control ; high frequency (HF) signal injection method ; I/F control ; model-based techniques ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 186
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This overview of the most recent advances in the field of SMA research and applications in civil engineering aims to help remove the knowledge barriers across disciplines and sheds considerable light on the opportunity to commercialize SMA products in the construction industry.
    Keywords: seismic analysis ; rocking pier ; shape memory alloy ; ECC material ; bridge engineering ; television transmission tower ; seismic excitation ; shape memory alloy damper ; parametric study ; vibration control ; shape memory alloys ; engineered cementitious composites ; composites materials ; self-recovery capacity ; bending behavior ; machine learning ; artificial neural networks ; superelastic ; parameter identification ; constitutive model ; thermodynamic parameters ; shape memory alloy (SMA) ; self-centering SMA brace ; loading rate ; initial strain ; energy dissipation coefficient ; self-centering ; beam-column joints ; seismic performance ; iron-based shape memory alloy (Fe-SMA) ; shape memory effect ; martensitic transformation ; prestressing ; low cycle fatigue ; seismic ; damping ; transmission tower ; wind excitation ; SMA damper ; energy response ; viscoelastic ; brace ; hybrid control ; seismic resilience ; self-centering rocking (SCR) piers ; seismic fragility ; resilience ; life-cycle loss ; ferrous shape memory alloys ; prestress ; recovery stress ; relaxation ; thermomechanical behavior ; fatigue ; active materials ; low-cost SMAs ; civil engineering applications ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 187
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The evaluation of vascular stiffness is becoming increasingly important in cardiovascular research to determine the properties of the arterial tree and clinically assesspatients. Current research addresses and debates some unresolved technical and methodological issues with measuring arterial stiffness, with the purpose of making it more reliable and clinically suitable. This Special Issue focuses on new methodological advances in vascular stiffness, as well as preclinical and clinical applications. A privileged space is reserved for new data and targeted reviews of the application of arterial stiffness and early vascular ageing measures regarding problems such as the stratification of risk of special populations and specific diseases.
    Keywords: arterial stiffness ; Arteriograph ; obstructive sleep apnea (OSA) ; continuous positive airway pressure (CPAP) ; metabolic syndrome (MS) ; adherence ; abdominal aortic aneurysm ; diabetes mellitus type 2 ; inflammatory marker ; vascular stiffness ; cardiovascular death ; degenerative aortic stenosis ; heat failure episodes ; pulsatile index ; resistive index ; aortic valve replacement ; transcatheter aortic valve implantation ; energy drinks ; pediatrics ; prevention ; aorta ; arterial distensibility ; augmentation index ; blood pressure amplification ; cardiovascular prevention ; elastic modulus ; pulse wave analysis ; pulse wave velocity ; prediabetes ; 11-dh-thromboxane ; cardiovascular risk ; IMT ; familial hypercholesterolemia ; selective LDL apheresis ; PCSK9 inhibitor monoclonal antibody ; thyroid ; parathyroid ; cardiovascular disease ; carotid distensibility ; carotid strain ; Young’s elastic modulus ; carotid compliance ; systemic sclerosis ; scleroderma ; vascular ageing ; central hemodynamics ; gut microbiota ; gut microbiome ; inflammation ; oxidative stress ; altitude ; altitude sickness ; aortic stiffness ; aortic distensibility ; atrial natriuretic factor ; blood pressure ; vascular age ; risk factors ; carotid distension ; primary prevention ; CAVI ; CAVI0 ; PWV ; comorbidity ; aging ; echo-tracking ; vascular ultrasound ; arterial properties ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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  • 188
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This Special Issue includes nine original contributions focused on river hydraulics. Four of these resulted from cooperation between universities from different countries: (a) Russia and Poland , (b) Taiwan and the USA , (c) Iran and Italy, and (d) India and Italy . The other contributions resulted from research carried out in universities from South Korea [5], Greece [6], China , and Japan .
    Keywords: bed roughness ; open-channel flow ; OpenFOAM ; Reynolds-averaged Navier–Stokes model ; turbulence model ; two-dimensional dune ; 60° bend ; bed shear stress ; turbulent kinetic energy ; Reynolds shear stress ; log-law ; continuous bend ; transition section ; correlation of flow movement ; width/depth ratio ; circulation structure ; circulation intensity ; numerical simulation ; local scour ; spur dike ; angle of repose ; river sediment transport modeling ; alluvial channels ; hydraulic riverbed resistance ; mathematical modeling ; van Rijn sediment transport formula ; local scouring ; bridge pile group ; material harvesting pit ; hydrodynamic bridge pier ; flow pattern ; FLOW-3D ; bed load transport ; random forests ; Gaussian processes regression ; Meyer–Peter and Müller formula ; sediment transport ; incision ; meandering ; bedrock ; curved channel ; bed configurations ; annular flume ; cover lid rotation speed ; developing flow ; fully-developed flow ; Reynolds stress anisotropy tensor ; seepage flow ; turbulence intensity ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 189
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: In recent years, applied marine sciences and engineering has attracted worldwide attention, which includes basic theoretical research and applied research on marine hydrology, meteorology, physics and geology. Besides, new viewpoints, new developments, new theories, new methods, new applications and new experiences of investigation, research and management in the marine environment and big data, ocean and coastal engineering, marine/coastal disaster and risk assessment, river dynamics, marine ecological environment, marine instruments and equipment, etc. are also included. This Special Issue aims to address the recent advances in marine environmental information and the application of marine environmental information.
    Keywords: Marine science ; Ocean Engineering ; Marine geology ; Marine environment ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 190
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint features 12 research articles that contribute to the research on lubricated bearings. The articles focus on the latest steps in understanding bearing operating behavior, its interaction with lubricants, and its role as a component in the drive train. In addition to the description of novel modeling approaches, a variety of experimental data are presented to provide interesting identification results as well as validation data for the research and engineering community.
    Keywords: journal bearing ; rotor stability ; floating ring bearing ; lobe bearing ; wave bearing ; lemon bearing ; Hopf bifurcation ; sliding bearings ; tilting pad journal bearings ; flow transition ; laminar flow ; turbulent flow ; non-laminar regime ; temperature reduction ; load capacity increase ; tilting-pad journal bearing ; pad deformation ; heat transfer ; trailing edge groove ; CFD ; power loss ; run-up simulation ; semi-floating ring bearing ; thrust bearing ; two-phase flow cavitation ; oil-whirl and oil-whip ; aerostatic bearings ; compensation ; infinite stiffness ; diaphragm valve ; design ; acoustic ; computational fluid dynamics (CFD) ; lubrication ; roughness ; planet gear bearing ; misalignment ; mixed friction ; wear ; wind turbine gearbox ; structure deformation ; metal-polymer plain bearings ; PA6-based polyamide composites ; dispersed glass and carbon fibers ; temperature ; Young’s modulus ; maximum contact pressures and resource ; boundary and dry friction ; lithium grease ; graphene ; load-carrying capacity ; wear scar ; infrared thermography ; vibration analysis ; damping ratio ; wettability ; lubrification ; oleophilicity ; hydrophobicity ; laser surface texturing ; experimental investigation ; lubrication method ; flooded bearing design ; non-flooded bearing design ; spray-bar ; leading edge groove ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 191
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Our era is characterized by two major phenomena. On the one hand, we are confronted by climate and environmental crises constituted by, among others, changing weather patterns, loss of biodiversity and natural wildlife, and ecosystem degradation. On the other hand, we are experiencing an ongoing technological evolution culminating in the rise of artificial intelligence (AI). The popular notion of “AI for Sustainability” constitutes an attempt to connect these two phenomena in a beneficial way by using AI to alleviate climate and environmental worries. AI is increasingly being used in the analysis, mitigation, and prevention of the climate and environmental crises and their effects. Much less attention has been paid to the idea of the “Sustainability of AI”, which focusses on the materiality of AI technologies themselves. Indeed, what are the hidden costs of AI? Although we use AI in combatting the climate and environmental crises, does it not have its own contributions to these crises? And, if so, how do we account for these contributions? The Special Issue is the first attempt to address the topic of “Sustainable AI” from a multi-disciplinary perspective. The authors that contributed to this issue come from diverse fields such as philosophy, ethics, sociology, law, and engineering. The included papers represent the first steps in understanding what it means to tackle the climate and environmental crises with AI while refraining from aggravating these crises.
    Keywords: artificial intelligence ; Sustainable Development Goals ; ESG ; CSR ; reporting ; disclosure ; sustainability ; sustainable AI ; greenwashing ; unfair commercial practices ; AI Act ; digitalization ; sustainable digitalization ; sustainable development ; SDGs ; Assessment Framework ; mindful ; digital age ; digitainability ; digital technologies ; qualitative research ; environmental impact ; carboncentric ; technocentric ; surrogate-based optimisation ; surrogate model ; sequential model-based optimisation ; Bayesian optimisation ; Green AI ; machine learning ; intergenerational justice ; future generations ; policy-making ; explainability ; transparency ; AI ; AI governance ; ethics ; ethical AI ; differential privacy ; AI certification ; ethics of AI ; AI ethics ; checklist ethics ; ethics of carefulness ; ethics of desirability ; climate justice ; infrastructure ; climate change ; nudging ; digital nudging ; libertarian paternalism ; autonomy ; carbon footprint ; LCA ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 192
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Primary energy consumption around the world has been increasing steadily since the Industrial Revolution and shows no signals of slowing down in the coming years. This trend is accompanied by the increasing pollutant concentration on the Earth’s biosystems and the general concerns over the health and environmental impacts that will ensue. Air quality, water purity, atmospheric CO2 concentration, etc., are some examples of environmental parameters that are degrading due to human activities. These ecosystems can be safeguarded without renouncing industrial development, urban and economic development through the use of low environmental impact technologies instead of equivalent pollutant ones or through the use of technologies to mitigate the negative impact of high emissions technologies. Pollutant abatement systems, carbon capture technologies, biobased products, etc. need to be established in order to make environmental parameters more and more similar to the pre-industrialization values of the planet Earth. In 15 papers international scientists addressed such topics, especially combining a high academic standard coupled with a practical focus on green processes and a quantitative approach to environmental impacts.
    Keywords: environmental compliance ; enterprise innovation ; Chinese manufacturing enterprises ; U-shaped relationship ; anaerobic digestion ; digestate ; liquid-solid separation ; membrane separation ; nutrient recovery ; membrane fouling ; biomass ; syngas scrubber wastewater ; environmental pollution ; pollutant abatement technologies ; biochar ; adsorption ; air quality ; Saharan dust ; mineral dust ; toxicity assessment ; luminescent bacteria ; acute and chronic toxicity ; environmental stringency policies ; human development ; CO2 emissions ; panel cointegration and causality analyses ; hydroelectricity consumption ; economic growth ; urbanization ; China ; crop production ; agricultural carbon emissions ; EKC ; decoupling ; LMDI ; innovative human capital ; CO2 emission ; Chinese provinces ; emissions trading system ; green total factor productivity ; spatial difference-in-difference ; energy efficiency ; green innovation ; industry structure ; spatial heterogeneity ; carbon tax ; low-carbon economy ; double dividend ; CGE model ; tax neutrality ; carbon tax recycling system ; human resource management (HRM) ; green psychological climate (GPC) ; green organizational culture (GOC) ; environmental concerns ; economic performance ; CEO tournament incentive ; tournament theory ; state-owned enterprises ; carbon tax recycling policy ; green economy ; technological progress ; triple dividend ; carbon emissions ; channeled emission ; emission factor ; particulate matter ; abatement technology ; ceramic industry ; PM10, PM2.5, and PM1 ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 193
    Publication Date: 2023-10-05
    Description: Advances in information technology are heavily influencing ways in which business, society, and government work and function throughout the globe, bringing many changes to everyday life, in a process commonly termed the "information revolution." This book paints a picture of the state of the information revolution today and how it will likely progress in the near- to mid-term future (10 to 15 years), focusing separately on different regions of the world-North America, Europe, the Asia-Pacific region, Latin America, the Middle East and North Africa, and sub-Saharan Africa.
    Keywords: Political Science ; Technology ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 194
    Publication Date: 2023-04-05
    Description: The active molecules or bioactives (i.e., polysaccharides, fatty acids, proteins, polyphenols, diterpenes, steroids and alkaloids) from algae (seaweed and microalgae) have been widely studied in recent years for multiple pharmaceutical and nutraceutical applications. Innovative and emerging technologies, including but not limited to ultrasounds, microwaves, electric fields, high-pressure supercritical fluids, ionic fluids and plasma, are currently being explored throughout multiple stages of the pre-treatment, extraction, isolation/purification and preservation of biomolecules from algae. This Special Issue will target research papers, reviews, short communications and perspectives on the use of novel technologies for the pre-treatment, extraction, isolation‒purification, characterization and preservation of marine compounds from algae. It will particularly focus on novel research related to algal bioactives with clear and demonstrated industrial applications and focuses.
    Keywords: seaweed ; innovative technology ; extraction ; polyphenol ; nutraceuticals ; Sargassum fusiforme polysaccharides ; high-fat diet ; cecal microbiota ; fecal microbiota ; 16S rRNA gene sequencing ; fucosterol ; algae ; toxicity ; in vivo ; in vitro ; adaptive laboratory evolution ; microalgal production ; environmental tolerance ; ceramides ; MCF-7 ; Ehrlich ascites carcinoma ; VEGF-B ; TNF-α ; midkine ; apoptosis ; p53 ; LC-ESI-HRMS ; Hypnea musciformis ; Cystoseira compressa ; microwave-assisted extraction ; green extraction ; biological activity ; seasonal variations ; fatty acids ; marine biome ; marine bioactive peptides ; natural resources ; bioactivities ; pharmacology ; biomedical ; therapeutic attributes ; in silico ; biotechnology ; cryptides ; anti-hypertensive ; antioxidant ; anti-cancer ; biopharmaceuticals ; recombinant proteins ; transient expression ; viral vectors ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 195
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Europe’s zero-pollution agenda should depart from an understanding of how the European citizens’ bodies are polluted by synthetic chemicals and prioritize the reduction of the chemical body burden and associated health impacts. In this context, Human Biomonitoring (HBM) is an important and valuable tool for assessing the internal exposure of humans resulting from aggregated exposure to chemicals. Though many obstacles still hinder the use of HBM data, the growing availability of HBM data offers an opportunity for improving and refining Human Risk Assessment. This Special Issue intends to illustrate, using case studies, how HBM data could be used to better estimate internal exposure and resulting risks. Case studies on exposure from consumer products (cosmetic products, non-food products, etc.) or exposures via food or water in the general population or among workers contributed to better identifying the obstacles hindering a broader use of HBM data in RA. A better understanding of population exposure and the exposure of vulnerable groups against health-based human biomonitoring guidance values also provides the basis for effective risk management to reduce impacts on health. I would like to thank all the authors for submitting their original contributions to this Special Issue. We greatly appreciate the support of all the reviewers who spent time evaluating and improving the quality of the manuscripts. I would also like to thank the editors of Toxics for their kind invitation and Selena Li of the Toxics Editorial Office for her invaluable support.
    Keywords: biomonitoring ; nanoparticles ; lung diseases ; mineralogical analysis of broncho-alveolar lavages ; occupational exposure ; human biomonitoring ; UV filters ; benzophenone-3 ; HBM4EU ; risk assessment ; RCR ; margin of safety ; oxidative stress ; MDA ; systematic review ; meta-analysis ; urinary biomarker ; reference range ; general population ; pesticides ; exposure ; operators ; workers ; residents ; bystanders ; tree-grown produce ; fruits ; vine ; systemic exposure ; paints production ; TiO2 powders ; biological monitoring ; exhaled breath condensate ; occupational health ; ortho-toluidine ; urinary mass-balance ; PBPK modelling ; human biomonitoring (HBM) ; internal exposure ; biomarkers ; endocrine disruptors ; bisphenol A (BPA) ; bisphenol S (BPS) ; bisphenols ; human biomonitoring guidance value (HBM-GV) ; physiologically based pharmacokinetic modelling (PBPK) ; organophosphorus flame retardants ; dietary exposure ; children ; malondialdehyde ; reference values ; benzene ; COVID-19 pandemic ; lockdown ; Rome ; elements ; urban traffic ; metabolomics ; dimethylformamide ; DMF ; HBM-GV ; guidance value ; biomarker ; toxicokinetics ; health effects ; liver ; carcinogenicity ; reprotoxic effects ; chlorpyrifos ; pesticide exposure ; pesticide risk assessment ; mercury ; methylmercury ; European Human Biomonitoring Initiative (HBM4EU) ; co-exposure ; workplace ; mixture risk assessment (MRA) ; adipose tissue ; meta-regression ; partition coefficients ; persistent organic pollutants ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 196
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Arthritis has a high prevalence globally and includes over 100 types; the most common types are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. All types of arthritis share common features, including monocyte infiltration, inflammation, synovial swelling, pannus formation, stiffness in the joints, and articular cartilage destruction. The exact etiology of arthritis remains unclear, and no cure exists as of yet. Anti-inflammatory drugs (NSAIDs and corticosteroids) are commonly used for the treatment of arthritis. However, these drugs are associated with significant side effects, such as gastric bleeding and an increased risk of a heart attack and other cardiovascular problems. Therefore, it is crucial that we continue to research the pathogenesis of arthritis and novel modes of therapy. This reprint summarizes and discusses the themes of 19 articles published in our Special Issue “Research of Pathogenesis and Novel Therapeutics in Arthritis 3.0”. The reprint details important novel research discoveries that contribute to our current understanding of arthritis.
    Keywords: Arthritis ; Treatment ; Molecular mechanisms ; Inflammatory cytokines ; Prevention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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  • 197
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In order to be able to analyze and give proper advice on sport techniques, it is important to understand the biomechanical and physiological demands of different sports. In a coaching situation, feedback to the athlete should be given without too much delay. Over the past decades, sensor technology-related to sports monitoring has developed with huge steps. Senors are lighter, data transmission is mostly wireless, and software applications are more user-friendly. This reprint is addressed to all kinds of sensors that are currently being used for monitoring different sports.
    Keywords: bending sensors ; flexion ; PyzoFlex ; ski bending ; ski deflection ; micro-sensor technology ; GNSS ; IMU ; disability ; heterogenous group ; cross-country skiing race ; performance analysis ; sub-technique classification ; time factor ; kayaking ; biomechanics ; canoe polo ; inertial measurement unit ; kinetics ; lower limbs ; load cells ; foot strap ; foot rest ; force measurements ; wearable sensors ; inline figure skating ; sports biomechanics ; human movement analysis ; propulsive force ; V2-skating skiing technique ; double-poling skiing technique ; global positioning system ; tracking system ; quantification ; substitutes ; high-intensity ; compensatory training ; monitoring system ; alpine skiing ; micro-electro-mechanical system sensors ; sport engineering ; training ; neural network ; motion sensor ; dance analysis ; data visualization ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 198
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions.
    Keywords: COVID-19 ; drug repurposing ; topological data analysis ; persistent Betti function ; SARS-CoV-2 ; network-based pharmacology ; combination therapy ; nucleoside GS-441524 ; fluoxetine ; synergy ; antidepressant ; natural compounds ; QSAR ; molecular docking ; drug repositioning ; UK Biobank ; vaccine ; LC-2/ad cell line ; drug discovery ; docking ; MM-GBSA calculation ; molecular dynamics ; cytotoxicity assay ; GWAS ; multiple sclerosis ; oxidative stress ; repurposing ; ADME-Tox ; bioinformatics ; complex network analysis ; modularity clustering ; ATC code ; hidradenitis suppurativa ; acne inversa ; transcriptome ; proteome ; comorbid disorder ; biomarker ; signaling pathway ; druggable gene ; drug-repositioning ; MEK inhibitor ; MM/GBSA ; Glide docking ; MD simulation ; MM/PBSA ; single-cell RNA sequencing ; pulmonary fibrosis ; biological networks ; p38α MAPK ; allosteric inhibitors ; in silico screening ; computer-aided drug discovery ; network analysis ; psychiatric disorders ; medications ; psychiatry ; mental disorders ; toxoplasmosis ; Toxoplasma gondii ; in vitro screening ; drug targets ; drug-disease interaction ; target-disease interaction ; DPP4 inhibitors ; lipid rafts ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: The book is the reprint of the Special Issue 'Advances in Sustainable and Digitalized Factories: Manufacturing, Measuring Technologies and Systems' published in the journal Applied Science (MDPI). It contains 17 articles, including 1 Editorial, 14 Research Papers, and 2 Reviews.
    Keywords: Industry 4.0 ; continuous improvement ; lean manufacturing ; lean production systems ; lean 4.0 ; systematic literature review ; tiny RFID ; metallic electromagnetic isolation ; analog manometer ; Ansys HFSS simulator ; passive digitization ; ontology ; production simulation ; multi-agent ; digital twin ; augmented reality ; industry 4.0 ; quality 4.0 ; metrology ; assembly ; turbine blades ; re-manufacturing ; uncertainty ; robust scheduling ; case-based reasoning ; failure mode ; effect and criticality analysis ; knowledge-based system ; nearest neighbor ; reliability-centered maintenance ; virtual reality ; cyber physical system ; OPC UA ; CAD ; industrial IoT ; prototyping ; retrofitting solutions ; embedded solutions ; low-cost ; value chain ; additive manufacturing ; subtractive manufacturing ; cost comparison ; plant simulation ; technology comparison ; hybrid dependability modelling ; production scheduling ; dynamic failure rate ; discrete event simulation ; time-driven simulation ; machine learning ; manufacturing ; artificial intelligence ; smart manufacturing ; digitization ; smart surface ; friction force field ; under-actuation ; feeding ; simulation ; material flow handling ; intralogistics ; robotic bin-picking ; simulation model ; ADAMS ; pick-point determination ; MATLAB/Simulink ; 2-F robotic gripper ; performance analysis ; plastic injection molding ; design of experiments ; process optimization ; facility layout problem ; evolutionary algorithms ; numerical modeling ; multi-objective optimization ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
    Language: English
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  • 200
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Marine engines are efficient machines, but stricter legislation about emissions makes continuous research necessary in order to reduce their consumption and improve their efficiency. This Special Issue, “Marine Engines Performance and Emissions II”, is a continuation of “Marine Engines Performance and Emissions”. It contains a set of peer-reviewed works about marine engine performance and emissions.
    Keywords: turbocharger diagnostics ; large diesel engine ; acoustic spectral analysis ; DFT leakage ; mechanical properties ; tensile strength ; laser sintering ; fracture ; additive technology ; rapid prototyping ; silencer ; composite scrubber ; transmission loss ; pressure drop ; noise reduction ; sulfur oxides ; marine gearboxes ; gear wheel shapes ; forged spur gear ; casted spur gear ; meshing stiffness ; gear teeth deformation ; FEM ; emissions ; alternative fuels ; combustion engine ; environment ; ammonia ; decarbonization ; marine engines ; ship emission ; scenario simulation ; automatic identification system (AIS) ; carbon emissions ; geographic information system (GIS) ; linear rolling systems ; ship emissions ; vibrodiagnostics ; wear ; compact system ; sold liquids ; metrology ; gas station dispensers ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
    Language: English
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