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  • bic Book Industry Communication::M Medicine  (1,155)
  • thema EDItEUR::N History and Archaeology::NH History::NHD European history  (1,082)
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  • 201
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    Radboud University Press
    Publication Date: 2023-11-17
    Description: In his professional journey, travelling through an upcoming field of surgery with apparently unlimited possibilities, Kees van Laarhoven witnessed major milestones and breakthroughs. Already as a medical student, he was amazed by surgical courage. During residency, he experienced hard work, diligence and perseverance of surgical professionals. Today as a surgeon with over 25 years of clinical experience he now looks at pieces of art in surgery with professionals compassionately bringing hope to patients.But he also sees inconvenient truths in our healthcare system, with patients evolving from one predictable and preventable disease to the next and with professionals following disease trends rather than applying their knowledge to redirect disease into health. The modern disease-oriented care system becomes undesirable and unsustainable. And there are more inconvenient truths that have progressed rather than diminished in time. Healthcare is not easily accessible to the major half of the global population and for those who have access, with a growing global population, healthcare may become unaffordable in the future. Moreover, from an environmental perspective, both human and planetary health are compromised and ask for a ‘One Health’ approach. Being fascinated by the questions of how and why did this all happen, Kees van Laarhoven took up a scientific survey to comprehend and learn how things still can be changed. He found that clear solutions are there! Please join him on his journey.
    Keywords: Global population overgrowth; Economic drivers of disease; Environmental drivers of disease; Prevention and integrative health; One health; Human and planetary health ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCQ Health economics ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services ; bic Book Industry Communication::V Health & personal development ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
    Language: English
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  • 202
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    Liverpool University Press
    Publication Date: 2024-04-04
    Description: This book caters for the demand in new black histories by rediscovering several little-known Black people’s experiences in late-Victorian Britain. It centres on The African Institute of Colwyn Bay, or ‘Congo House’, at which almost 90 children and young adults from Africa and its diaspora were enrolled to train as missionaries between 1889 and 1911. Burroughs finds that, though their encounters in Britain were shaped by the racism and paternalism of the late-nineteenth-century civilising mission, the students were not simply the objects of British charity. They were also agents in a culture of evangelical humanitarianism. Some were fully absorbed in the civilising mission, becoming leading missionaries. Others adapted their experiences to new ends, participating in networks of pan-Africanism that questioned race prejudice and colonialism. In their negotiations of the challenges and opportunities at the heart of the empire, the students of Congo House reveal how the global currents of black history shaped the localised cultures of Victorian philanthropy. From racism to pan-Africanism, this study sheds new light on key issues in black British history.
    Keywords: History ; British Studies ; European Studies ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 203
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    Amsterdam University Press
    Publication Date: 2024-04-02
    Description: While it is clear that around 1800 the humanities as a discipline rose to prominence, it is less clear what the exact nature of this shift in academia was. Was it a sudden revolution caused by a momentary but powerful change in the zeitgeist or the turning point of a much longer process? In this volume, the editors have selected a series of essays that look at the origins of the humanities and find that long before 1800 the concept of the humanities was already at the fore. The shift around 1800 was thus mostly institutional, not theoretical. The Making of the Humanities traces this new finding through a broad range of disciplines including literary theory, linguistics, art history, and musicology.
    Keywords: History ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 204
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    Manchester University Press | Manchester University Press
    Publication Date: 2024-04-02
    Description: This study explores the practice of scientific enquiry as it took place in the eighteenth-century home. While histories of science have identified the genteel household as an important site for scientific experiment, they have tended to do so via biographies of important men of science. Using a wide range of historical source material, from household accounts and inventories to letters and print culture, this book investigates the tools within reach of early modern householders in their search for knowledge. It considers the under-explored question of the home as a site of knowledge production and does so by viewing scientific enquiry as one of many interrelated domestic practices. It shows that knowledge production and consumption were necessary facets of domestic life and that the eighteenth-century home generated practices that were integral to ‘Enlightenment’ enquiry.
    Keywords: History ; Modern ; 18th Century ; Science ; History ; Europe ; Great Britain ; Georgian Era (1714-1837) ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 205
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    Presses universitaires de Caen
    Publication Date: 2024-04-02
    Description: La mémoire collective nationale, qui a bien intégré le souvenir de la première femme bachelière, ne se souvient pas de celle qui fut la première à se voir décerner le titre de docteur ès lettres en histoire. Pas davantage dans sa région que dans son département d’origine ! Pourtant, elle est Normande. Après une licence de lettres obtenue à Caen et des études à la Sorbonne, c’est en 1923 que Madeleine Deries, une Saint-Loise, a ce privilège. L’événement est salué partout comme l’aboutissement d’une longue démarche d’émancipation féminine. Les amis, la presse, la communauté tout entière ne ménagent pas leurs congratulations hautement méritées. Ses thèses ont été publiées – Le district de Saint-Lô pendant la Révolution et L’École centrale du département de la Manche : an IV-an XI –, suivies d’articles d’un incontestable intérêt historique. Madeleine Deries représente cette longue revendication légitime d’égalité des sexes devant la connaissance. La jeune Saint-Loise, de ce point de vue, à la manière d’un guide de haute montagne, est une ouvreuse de voie. Son parcours, exemplaire à plus d’un titre, méritait bien qu’on s’y attarde. Et, pour ajouter à la pertinence de l’entreprise, la jeune femme, née en 1895, pleinement inscrite dans la vie locale saint-loise et caennaise du début du XXe siècle, va également vivre intensément les événements liés à la Grande Guerre avant de rejoindre Paris et sa prestigieuse université, la Sorbonne, tout en éprouvant les heurs et malheurs de la vie conjugale et de la maternité. Ce portrait de femme, raconté à la manière d’une passionnante enquête, contribue incontestablement à dissiper l’insupportable silence qui entoure ces pionnières oubliées.
    Keywords: biographie ; doctorante ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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  • 206
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    Archaeopress Publishing Ltd
    Publication Date: 2024-04-02
    Description: Over the past few decades, there has been a significant amount of research on the Roman Lower Danube frontier by international teams focusing on individual forts or broader landscape survey work; collectively, this volume represents the best of this collaboration with the aim of elevating the Lower Danube within broader Roman frontier scholarship.The Lower Danube, running between Singidunum (modern Belgrade) and Halmyris in the Danube Delta, was one of the most densely fortified regions of the Roman Empire. The region has long been a border zone, today forming part of the border between Serbia and Romania, and the majority of the border between Romania and Bulgaria. Despite its importance for understanding both Roman frontier policy and the relationship between ancient and modern borderscapes, the region has not yet made its full contribution to international Roman scholarship. Bridging the theoretical divide that exists between different regional research traditions, chapters in this volume focus on sites like Ratiaria, in modern north-western Bulgaria, while other contributors examine the complex landscape from a wider perspective oriented around roads, temporary camps, or early Christian sites. The Roman Lower Danube Frontier emphasises the importance of engaging with Roman frontier landscapes, particularly in regions such as East-Central Europe, where they remain part of a contemporary borderscape.
    Keywords: History ; Ancient ; Rome ; Social Science ; Archaeology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NK Archaeology
    Language: English
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  • 207
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-04-04
    Description: This open access book discusses the emergence and development, and in some cases also the disappearance, of social movements and activism in Sweden during the 1980s. Its aim is to nuance and problematize the image of the 1980s as unilaterally dominated by right-wing politics and neoliberalism, as well as the idea of a conflict-free Scandinavian model. The 1980s have often been described as a period when the influence of radical-left movements during the 1970s diminished. Instead, this book argues that the 1980s was a decade in which new radical social movements emerged in opposition to the prevalent political order, including the nuclear disarmament movement, the women's movement, anti-fascist movements, and the punk and environmental movements. The authors also demonstrate how issues such as squatting, nuclear resistance, rent strikes and the environment, included a variety of contentious collective action. Sweden, therefore, presents an interesting example of how resistance and conflict in a strong welfare state have been influenced by contentious social movements. Placing Sweden within the wider context of Scandinavia and Europe, this edited collection makes an important contribution to the history of social movements.
    Keywords: Political activism ; Protest ; Swedish history ; Riots ; Scandinavian history ; Conflict ; Violence ; Nuclear disarmament ; Women's movement ; Anti-fascist movement ; Punk movement ; Environmental movement ; Militancy ; Left-wing politics ; Labour history ; Welfare state ; Rent strikes ; Squatting ; History of welfare ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies
    Language: English
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  • 208
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: The purpose of this Special Issue “The Role of Nutrition in Cardiometabolic Health: Experimental, Clinical, and Community-Based Evidence” is to publish a focused, coherent, impactful, and well-cited volume on how nutrition influences diverse cardiometabolic risk factors. Cardiometabolic diseases, such as coronary heart disease, stroke, type 2 diabetes mellitus, and obesity, is the leading cause of death worldwide. In recent years, dietary habits have shifted all over the globe. At the same time, a constantly growing body of evidence demonstrates the role of caloric intake and dietary composition as determinants of cardiometabolic health. Suboptimal diet predisposes to a myriad of cardiometabolic risk factors such as impaired glucose metabolism, insulin resistance, dyslipidaemias, and high blood pressure.
    Keywords: vitamin D ; obesity ; microvascular ; bariatric surgery ; weight loss ; nitric oxide ; cardiac remodeling ; cardiac dysfunction ; echocardiogram ; obese rats ; high-fat high-sugar diet ; vascular stiffness ; blood pressure ; whey protein isolate ; older adults ; dietary factor ; cardiovascular disease ; umbrella review ; low-carbohydrate diet ; hypocaloric ; isocaloric ; women health ; conduit artery ; microvasculature ; cardiovascular risks ; primary prevention ; homocysteine ; folate ; vitamin B12 ; vascular dysfunction ; hepatocyte ; TGR5 ; glucose regulation ; homocysteine and vascular disease ; H3K27me3 ; epigenetics ; atherosclerosis ; MRI (magnetic resonance imaging) ; liver ; metabolic regulation ; laparoscopic sleeve gastrectomy ; micronutrients ; deficiency ; body mass index ; cardiotonic steroids ; left ventricular mass ; marinobufagenin ; dietary salt intake ; young adults ; bic Book Industry Communication::M Medicine
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  • 209
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: In this Special Issue, we have compiled data and opinions from leading scientists to demonstrate the recent advances in the study of function and dysfunction of synucleins. These proteins are involved in multiple normal and pathological molecular processes and consequently have various effects on cell biology of the nervous system. Three members of the synuclein family share many structural properties and have an overlapping pattern of expression and intracellular distribution in the developing and adult nervous system, which point to functional redundancy within the family. However, each synuclein has its own functions which are not shared with the two other family members, and there are certain cellular mechanisms and pathways in which these functions could be antagonistic rather than synergistic.
    Keywords: prenatal alcohol exposure ; synucleins ; alcohol consumption ; free-choice ; hippocampus ; midbrain ; mRNA expression ; α-synuclein ; rats ; dopaminergic neuron ; MPTP ; knockout mice ; Parkinson’s disease ; alpha-synuclein ; SH-SY5Y ; hiPSCs ; organoid ; aggregation ; synucleinopathy ; blood–brain barrier ; microglia ; astrocytes ; overexpression ; mutation ; Lewy body ; synucleinopathies ; multiple system atrophy ; dementia with Lewy bodies ; deep brain stimulation ; focused ultrasound ; gene therapy ; surgical techniques ; dopamine ; electroencephalogram ; frequency spectrum ; α-, β- and γ-synuclein ; epigenetic ; protein aggregation ; SNARE-complex ; protein trafficking ; phytochemicals ; methylation ; histones ; γ-synuclein ; autoantibodies ; glaucoma ; α2-macroglobulin ; tear fluid ; intraocular pressure ; SARS-CoV-2 spike RBD domain ; amyloid aggregation ; post-COVID-19 neurodegeneration ; SARS-CoV-2 vaccine ; depression ; serotonin ; raphe nuclei ; Lewy bodies diseases ; E46K-SNCA ; cognition ; nonmotor ; clustering analysis ; multimodal MRI ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 210
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: This reprint brings together a group of articles that were published as a Special Issue on prosthetic joint infection in the journal Antibiotics. They cover various aspects of risk factors and prevention, medical and surgical treatment, and outcomes of prosthetic joint infections.
    Keywords: prosthetic joint infection ; arthroplasty infection ; prosthetic joint infection functional outcome ; prosthetic joint infection ambulatory outcome ; tedizolid ; prosthetic joint infections ; prolonged oral treatment ; tolerance ; compliance ; surgical antimicrobial prophylaxis ; knee arthroplasty ; hip arthroplasty ; surgical site infection prevention ; prosthetic joint infection prevention ; intraoperative cultures ; antibiotic levels ; serum bactericidal titer ; oxazolidinones ; osteoarticular infections ; diabetic foot infections ; drug-drug interaction ; Staphylococcus aureus ; implant removal ; outcome ; rifampin ; biofilm ; knee ; total knee arthroplasty ; infection ; intra-articular injection ; surgical site infection ; epidemiology ; risk factors ; multidrug-resistant Gram-negative bacteria ; extensively drug-resistant ; hematoma ; hip hemiarthroplasty ; proximal femur fracture ; antibiotic prophylaxis ; periprosthetic joint infection ; decolonization ; daptomycin ; eosinophilic pneumonia ; Candida spp. ; fungus ; antifungal-loaded cement spacer ; two-stage exchange surgery ; Cutibacterium acnes ; surgical and medical treatment ; dalbavancin ; gram-positive ; sol-gel ; anidulafungin ; Candida albicans ; suppressive antibiotic treatment ; prolonged antibiotic ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine::MBNS Epidemiology & medical statistics
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  • 211
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    The MIT Press | The MIT Press
    Publication Date: 2024-04-04
    Description: An in-depth look at Ukraine's attempts to shape how it is perceived by the rest of the world.During times of crisis, competing narratives are often advanced to define what is happening, and the stakes of information management by nations are high. In this timely book, Göran Bolin and Per Ståhlberg examine the fraught intersection of state politics, corporate business, and civil activism to understand the dynamics and importance of meaning management in Ukraine. Drawing on fieldwork inside the country, the authors discuss the forms, agents, and platforms within the complex political and communicative situation and how each articulated and acted upon perceptions of the propaganda threat.Bolin and Ståhlberg focus their analysis on the period between 2013 and 2022, when political tensions, commercial dynamics, and new communication technologies bred novel forms of information management. As they show, entities from governments and governmental administration to commercial actors, entrepreneurs, and activists formed new alliances in order to claim a stake in information policy. Bolin and Ståhlberg also explore how the various agents engaged in information management and strove to manage meaning in communication practice; the communicative tools they took advantage of; and the subsequent consequences for narrative constructions.
    Keywords: Public diplomacy ; soft power ; strategic communication ; nation branding ; communication management ; Ukraine ; war ; protest ; revolution ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDK Science funding and policy ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDM Scientific research ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 212
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The evaluation of vascular stiffness is becoming increasingly important in cardiovascular research to determine the properties of the arterial tree and clinically assesspatients. Current research addresses and debates some unresolved technical and methodological issues with measuring arterial stiffness, with the purpose of making it more reliable and clinically suitable. This Special Issue focuses on new methodological advances in vascular stiffness, as well as preclinical and clinical applications. A privileged space is reserved for new data and targeted reviews of the application of arterial stiffness and early vascular ageing measures regarding problems such as the stratification of risk of special populations and specific diseases.
    Keywords: arterial stiffness ; Arteriograph ; obstructive sleep apnea (OSA) ; continuous positive airway pressure (CPAP) ; metabolic syndrome (MS) ; adherence ; abdominal aortic aneurysm ; diabetes mellitus type 2 ; inflammatory marker ; vascular stiffness ; cardiovascular death ; degenerative aortic stenosis ; heat failure episodes ; pulsatile index ; resistive index ; aortic valve replacement ; transcatheter aortic valve implantation ; energy drinks ; pediatrics ; prevention ; aorta ; arterial distensibility ; augmentation index ; blood pressure amplification ; cardiovascular prevention ; elastic modulus ; pulse wave analysis ; pulse wave velocity ; prediabetes ; 11-dh-thromboxane ; cardiovascular risk ; IMT ; familial hypercholesterolemia ; selective LDL apheresis ; PCSK9 inhibitor monoclonal antibody ; thyroid ; parathyroid ; cardiovascular disease ; carotid distensibility ; carotid strain ; Young’s elastic modulus ; carotid compliance ; systemic sclerosis ; scleroderma ; vascular ageing ; central hemodynamics ; gut microbiota ; gut microbiome ; inflammation ; oxidative stress ; altitude ; altitude sickness ; aortic stiffness ; aortic distensibility ; atrial natriuretic factor ; blood pressure ; vascular age ; risk factors ; carotid distension ; primary prevention ; CAVI ; CAVI0 ; PWV ; comorbidity ; aging ; echo-tracking ; vascular ultrasound ; arterial properties ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
    Language: English
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  • 213
    Publication Date: 2024-03-31
    Description: Mobilising a queer theoretical framework, by which we mean embracing unhappiness, ephemerality, and instability, this chapter reflects on processes of archiving oral histories as part of the European HIV/AIDS Archive (EHAA). It presents selected challenges and tensions that lie at the heart of remembering, narrating, and archiving the HIV/AIDS epidemic in the broader European region. The EHAA, an online collection of oral history interviews and digitised materials, has been developed to further establish HIV/AIDS history as part of the broader social memory, so as to work through the trauma of mass death and social discrimination and to document innovations, tensions, and inconsistencies in engaging with the epidemic across the region. 〈br /〉Building on a growing interest in archiving histories of HIV activism across Europe and North America, the EHAA project dates back to efforts by the ‘AIDS History into Museums Working Group’ to preserve such histories in Germany. The project was further developed and expanded in two research projects: ‘Disentangling European HIV/AIDS Policies: Activism, Citizenship and Health’ and ‘Don’t Criminalize Passion! The AIDS Crisis and Political Mobilization in the 1980s and early 1990s in Germany’. 〈br /〉Explicitly deviating from an investment in offspring as a route for the transmission of memory, the EHAA joins other queer archival work imagined as sites for handing down queer history. This chapter argues that the EHAA contributes to queer memory work as a necessary revision of public remembrance and current perceptions of the epidemic, and, at the same time, as a source of inspiration for future activism.
    Keywords: HIV/AIDS; archive; queer theory; queer counter-memory; utopia; European HIV/AIDS Archive; Europe; ephemera; affect theory; oral history ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases::MJCJ2 Medicine: HIV/AIDS, retroviral diseases ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPQ Later 20th century c 1950 to c 1999 ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MR 21st century, c 2000 to c 2100 ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
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  • 214
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    Eur’Orbem Éditions
    Publication Date: 2024-04-02
    Description: Through a selection of essays and articles by historian Ľubomir Lipták, the book explores the history of Slovakia, a landlocked country in the heart of Central Europe, at the junction of different linguistic areas. A multicultural country until the late 1930s, Slovakia became ethnically homogenous after the Second World War. This volume, edited by Roman Krakovsky, examines these transformations. It also invites us to reflect on the role of history and the historian in the city, collective identities. In Lipták's characteristically incisive style and writing, these texts present an uncompromising approach to the transformations that Slovakia and its region have undergone over the short twentieth century. They also help us to understand its present.
    Keywords: communism ; Public space ; ideology ; collective identities ; real communism ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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  • 215
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-04
    Description: This is the first scholarly volume to offer an insight into the less known stories of women, children, and international volunteers in the Spanish Civil War. Special attention is given to volunteers of different historical experiences, especially Jews, and voices from less researched countries in the context of the Spanish war, such as Palestine and Turkey. Of an interdisciplinary nature, this volume brings together historians and literary scholars from different countries. Their research is based on newly found primary sources in both national and private archives, as well as on post-essentialist methodological insights for women’s history, Jewish history, and studies on belonging. By bringing together a group of emerging and senior scholars from different countries, we highlight the polyphony of voices of diverse individuals drawn into the Spanish Civil War. Contributors to this volume have explored new or little researched primary sources found in archives and documentary centers, including papers held by relatives of the people we study. The volume is aimed at both scholarly and non-scholarly public, including any readers interested in the Spanish Civil War, twentieth-century European history, Jewish studies, women’s history, or anti-Fascism. The volume can be used in both undergraduate college courses and in postgraduate university seminars.
    Keywords: Spanish, Civil War, History ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
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  • 216
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    Open Book Publishers
    Publication Date: 2024-03-24
    Description: In republican times, one of Rome's deadliest enemies was King Mithridates of Pontus. In 66 BCE, after decades of inconclusive struggle, the tribune Manilius proposed a bill that would give supreme command in the war against Mithridates to Pompey the Great, who had just swept the Mediterranean clean of another menace: the pirates. While powerful aristocrats objected to the proposal, which would endow Pompey with unprecedented powers, the bill proved hugely popular among the people, and one of the praetors, Marcus Tullius Cicero, also hastened to lend it his support. In his first ever political speech, variously entitled pro lege Manilia or de imperio Gnaei Pompei, Cicero argues that the war against Mithridates requires the appointment of a perfect general and that the only man to live up to such lofty standards is Pompey. In the section under consideration here, Cicero defines the most important hallmarks of the ideal military commander and tries to demonstrate that Pompey is his living embodiment. This course book offers a portion of the original Latin text, study aids with vocabulary, and a commentary. Designed to stretch and stimulate readers, the incisive commentary will be of particular interest to students of Latin at both AS and undergraduate level. It extends beyond detailed linguistic analysis and historical background to encourage critical engagement with Cicero's prose and discussion of the most recent scholarly thought.
    Keywords: Language & Literature ; History ; thema EDItEUR::C Language and Linguistics::CJ Language teaching and learning ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval
    Language: English
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  • 217
    Publication Date: 2024-04-02
    Description: This volume presents a set of lessons learned from the United Kingdom’s Astute submarine program that could help inform future program managers. Designing and building a submarine requires careful management and oversight and a delegation of roles and responsibilities that recognizes which party—the shipbuilder or the government—is best positioned to manage risks.
    Keywords: Technology ; History ; Political Science ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::L Law::LB International law::LBB Public international law::LBBC Public international law: treaties and other sources ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
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  • 218
    Publication Date: 2023-04-05
    Description: The active molecules or bioactives (i.e., polysaccharides, fatty acids, proteins, polyphenols, diterpenes, steroids and alkaloids) from algae (seaweed and microalgae) have been widely studied in recent years for multiple pharmaceutical and nutraceutical applications. Innovative and emerging technologies, including but not limited to ultrasounds, microwaves, electric fields, high-pressure supercritical fluids, ionic fluids and plasma, are currently being explored throughout multiple stages of the pre-treatment, extraction, isolation/purification and preservation of biomolecules from algae. This Special Issue will target research papers, reviews, short communications and perspectives on the use of novel technologies for the pre-treatment, extraction, isolation‒purification, characterization and preservation of marine compounds from algae. It will particularly focus on novel research related to algal bioactives with clear and demonstrated industrial applications and focuses.
    Keywords: seaweed ; innovative technology ; extraction ; polyphenol ; nutraceuticals ; Sargassum fusiforme polysaccharides ; high-fat diet ; cecal microbiota ; fecal microbiota ; 16S rRNA gene sequencing ; fucosterol ; algae ; toxicity ; in vivo ; in vitro ; adaptive laboratory evolution ; microalgal production ; environmental tolerance ; ceramides ; MCF-7 ; Ehrlich ascites carcinoma ; VEGF-B ; TNF-α ; midkine ; apoptosis ; p53 ; LC-ESI-HRMS ; Hypnea musciformis ; Cystoseira compressa ; microwave-assisted extraction ; green extraction ; biological activity ; seasonal variations ; fatty acids ; marine biome ; marine bioactive peptides ; natural resources ; bioactivities ; pharmacology ; biomedical ; therapeutic attributes ; in silico ; biotechnology ; cryptides ; anti-hypertensive ; antioxidant ; anti-cancer ; biopharmaceuticals ; recombinant proteins ; transient expression ; viral vectors ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 219
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    Eur’Orbem Éditions
    Publication Date: 2024-04-02
    Description: En octobre 1918, l’Autriche-Hongrie implose avant même d’avoir connu sa dernière défaite militaire en Italie. En Pays tchèques, cette crise aboutit à la proclamation de la Tchécoslovaquie, projet politique inexistant quatre ans plus tôt. Cette transformation révolutionnaire emprunte à des dynamiques militaires, civiles, diplomatiques et politiques dont l’observation permet d’éclairer les forces centripètes et centrifuges qui s’exercent tant en Pays tchèques qu’à l’extérieur de la monarchie habsbourgeoise au cours de la Grande Guerre. Le présent ouvrage se propose d’observer comment ces dynamiques spatialement distinctes s’articulent pendant quatre années et laissent progressivement place à des synergies qui se combinent au cours des dernières semaines de 1917 et, surtout, du premier semestre 1918.
    Keywords: Central Europe ; intelligence ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Europe’s zero-pollution agenda should depart from an understanding of how the European citizens’ bodies are polluted by synthetic chemicals and prioritize the reduction of the chemical body burden and associated health impacts. In this context, Human Biomonitoring (HBM) is an important and valuable tool for assessing the internal exposure of humans resulting from aggregated exposure to chemicals. Though many obstacles still hinder the use of HBM data, the growing availability of HBM data offers an opportunity for improving and refining Human Risk Assessment. This Special Issue intends to illustrate, using case studies, how HBM data could be used to better estimate internal exposure and resulting risks. Case studies on exposure from consumer products (cosmetic products, non-food products, etc.) or exposures via food or water in the general population or among workers contributed to better identifying the obstacles hindering a broader use of HBM data in RA. A better understanding of population exposure and the exposure of vulnerable groups against health-based human biomonitoring guidance values also provides the basis for effective risk management to reduce impacts on health. I would like to thank all the authors for submitting their original contributions to this Special Issue. We greatly appreciate the support of all the reviewers who spent time evaluating and improving the quality of the manuscripts. I would also like to thank the editors of Toxics for their kind invitation and Selena Li of the Toxics Editorial Office for her invaluable support.
    Keywords: biomonitoring ; nanoparticles ; lung diseases ; mineralogical analysis of broncho-alveolar lavages ; occupational exposure ; human biomonitoring ; UV filters ; benzophenone-3 ; HBM4EU ; risk assessment ; RCR ; margin of safety ; oxidative stress ; MDA ; systematic review ; meta-analysis ; urinary biomarker ; reference range ; general population ; pesticides ; exposure ; operators ; workers ; residents ; bystanders ; tree-grown produce ; fruits ; vine ; systemic exposure ; paints production ; TiO2 powders ; biological monitoring ; exhaled breath condensate ; occupational health ; ortho-toluidine ; urinary mass-balance ; PBPK modelling ; human biomonitoring (HBM) ; internal exposure ; biomarkers ; endocrine disruptors ; bisphenol A (BPA) ; bisphenol S (BPS) ; bisphenols ; human biomonitoring guidance value (HBM-GV) ; physiologically based pharmacokinetic modelling (PBPK) ; organophosphorus flame retardants ; dietary exposure ; children ; malondialdehyde ; reference values ; benzene ; COVID-19 pandemic ; lockdown ; Rome ; elements ; urban traffic ; metabolomics ; dimethylformamide ; DMF ; HBM-GV ; guidance value ; biomarker ; toxicokinetics ; health effects ; liver ; carcinogenicity ; reprotoxic effects ; chlorpyrifos ; pesticide exposure ; pesticide risk assessment ; mercury ; methylmercury ; European Human Biomonitoring Initiative (HBM4EU) ; co-exposure ; workplace ; mixture risk assessment (MRA) ; adipose tissue ; meta-regression ; partition coefficients ; persistent organic pollutants ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Arthritis has a high prevalence globally and includes over 100 types; the most common types are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. All types of arthritis share common features, including monocyte infiltration, inflammation, synovial swelling, pannus formation, stiffness in the joints, and articular cartilage destruction. The exact etiology of arthritis remains unclear, and no cure exists as of yet. Anti-inflammatory drugs (NSAIDs and corticosteroids) are commonly used for the treatment of arthritis. However, these drugs are associated with significant side effects, such as gastric bleeding and an increased risk of a heart attack and other cardiovascular problems. Therefore, it is crucial that we continue to research the pathogenesis of arthritis and novel modes of therapy. This reprint summarizes and discusses the themes of 19 articles published in our Special Issue “Research of Pathogenesis and Novel Therapeutics in Arthritis 3.0”. The reprint details important novel research discoveries that contribute to our current understanding of arthritis.
    Keywords: Arthritis ; Treatment ; Molecular mechanisms ; Inflammatory cytokines ; Prevention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In order to be able to analyze and give proper advice on sport techniques, it is important to understand the biomechanical and physiological demands of different sports. In a coaching situation, feedback to the athlete should be given without too much delay. Over the past decades, sensor technology-related to sports monitoring has developed with huge steps. Senors are lighter, data transmission is mostly wireless, and software applications are more user-friendly. This reprint is addressed to all kinds of sensors that are currently being used for monitoring different sports.
    Keywords: bending sensors ; flexion ; PyzoFlex ; ski bending ; ski deflection ; micro-sensor technology ; GNSS ; IMU ; disability ; heterogenous group ; cross-country skiing race ; performance analysis ; sub-technique classification ; time factor ; kayaking ; biomechanics ; canoe polo ; inertial measurement unit ; kinetics ; lower limbs ; load cells ; foot strap ; foot rest ; force measurements ; wearable sensors ; inline figure skating ; sports biomechanics ; human movement analysis ; propulsive force ; V2-skating skiing technique ; double-poling skiing technique ; global positioning system ; tracking system ; quantification ; substitutes ; high-intensity ; compensatory training ; monitoring system ; alpine skiing ; micro-electro-mechanical system sensors ; sport engineering ; training ; neural network ; motion sensor ; dance analysis ; data visualization ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions.
    Keywords: COVID-19 ; drug repurposing ; topological data analysis ; persistent Betti function ; SARS-CoV-2 ; network-based pharmacology ; combination therapy ; nucleoside GS-441524 ; fluoxetine ; synergy ; antidepressant ; natural compounds ; QSAR ; molecular docking ; drug repositioning ; UK Biobank ; vaccine ; LC-2/ad cell line ; drug discovery ; docking ; MM-GBSA calculation ; molecular dynamics ; cytotoxicity assay ; GWAS ; multiple sclerosis ; oxidative stress ; repurposing ; ADME-Tox ; bioinformatics ; complex network analysis ; modularity clustering ; ATC code ; hidradenitis suppurativa ; acne inversa ; transcriptome ; proteome ; comorbid disorder ; biomarker ; signaling pathway ; druggable gene ; drug-repositioning ; MEK inhibitor ; MM/GBSA ; Glide docking ; MD simulation ; MM/PBSA ; single-cell RNA sequencing ; pulmonary fibrosis ; biological networks ; p38α MAPK ; allosteric inhibitors ; in silico screening ; computer-aided drug discovery ; network analysis ; psychiatric disorders ; medications ; psychiatry ; mental disorders ; toxoplasmosis ; Toxoplasma gondii ; in vitro screening ; drug targets ; drug-disease interaction ; target-disease interaction ; DPP4 inhibitors ; lipid rafts ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    Publication Date: 2024-04-02
    Description: Eschatology and discourses on the end of time are an important subject in medieval literature. In the Iberian Peninsula, the study of Beatus de Liébana has given rise to debates on the existence of apocalyptic fears linked to the approach of the year 800 or the year 1000, or following the Muslim conquest. This book aims to better integrate the Iberian situation into a broader panorama, and to highlight the scholarly character and diversity of a textual and iconographic production with multiple functions, which approaches the end of time from a perspective devoid of any apocalyptic urgency.
    Keywords: apocalypse ; Beatus of Liébana ; eschatology ; Islam ; al-Andalus ; medieval manuscript ; polemic ; millenarianism ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: French
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    University of London Press | University of London Press
    Publication Date: 2024-04-01
    Description: On 14 June 2017, flames engulfed a residential block of flats in West London. 72 people lost their lives and many hundreds more were traumatised as a national ‘cladding crisis’ unfolded. Yet the Grenfell Tower fire was a disaster foretold – the culmination of successive decades of deregulation, corporate greed and institutional failure to learn from the lessons of past multiple-fatality fires. By advocating a historical approach spanning the twentieth century, Before Grenfell deepens our contemporary understanding of the events surrounding the disaster and reveals how past decisions taken by governments and industry bodies created the conditions under which the fire occurred. Drawing upon unexplored archives as well as extensive use of published records, Shane Ewen’s book traces the underlying causes of the fire through more than four decades of deregulation of fire precautions, scientific governance and building regulations by successive governments in thrall to the ideology of neoliberalism. In drawing upon several previous, and often forgotten, multiple-fatality fires, the book sheds light on the historic failures of policymakers to heed the lessons of the past in protecting vulnerable communities, arguing that good policymaking necessitates learning with history as well as learning from history.
    Keywords: Grenfell ; fire ; fire safety ; Justice4Grenfell ; Grenfell United ; late-capitalism ; poverty ; building regulation ; housing development ; urban planning ; urban redevelopment ; high-rise ; tower blocks ; neoliberalism ; deregulation ; mass-fatality fires ; london ; tragedy ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MR 21st century, c 2000 to c 2100 ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials::TNKF Fire protection and safety
    Language: English
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    Berghahn Books | Berghahn Books
    Publication Date: 2024-04-02
    Description: It is difficult to speak about Europe today without reference to its constitutive regions—supra-national geographical designations such as “Scandinavia,” “Eastern Europe,” and “the Balkans.” Such formulations are so ubiquitous that they are frequently treated as empirical realities rather than a series of shifting, overlapping, and historically constructed concepts. This volume is the first to provide a synthetic account of these concepts and the historical and intellectual contexts in which they emerged. Bringing together prominent international scholars from across multiple disciplines, it systematically and comprehensively explores how such “meso-regions” have been conceptualized throughout modern European history.
    Keywords: History ; Historiography ; History ; Europe ; History ; Historical Geography ; thema EDItEUR::N History and Archaeology::NH History::NHA History: theory and methods::NHAH Historiography ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTP Historical geography
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    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Premier ouvrage abordant les violences faites aux femmes dans le 9e art, À coups de cases et de bulles est à même de montrer la façon dont la bande dessinée franco-belge, les comics mais aussi les mangas traitent les agressions et les crimes de sang. La bande dessinée qui ne cesse d’ouvrir de nouveaux chantiers et de revisiter des domaines déjà balisés, soit en les renouvelant, soit en les inscrivant dans une tradition, continue d’investir l’imaginaire des sociétés contemporaines. Quotidiens, hebdomadaires, trimestriels font désormais une place de plus en plus importante aux cases et aux bulles, mais si les femmes de papier ont été parfois mises à l’honneur ou étudiées, c’est rarement le cas des brutalités, des insultes et des viols qu’elles subissent. Et pourtant, les récits graphiques regorgent de femmes victimes de violences les plus diverses : mariages forcés, humiliations, agressions physiques, viols. Des bandes dessinées relèvent du témoignage et de la littérature du réel, d’autres appartiennent au registre de l’imaginaire, mais toutes traitent d’un fléau universel, parfois en une seule case, d’autres fois en plusieurs planches. La visée du présent ouvrage est d’inverser les perspectives communes, de montrer que les femmes ne sont pas enfermées dans la catégorie des femmes aguicheuses, ni dans celle des faire-valoir, ni non plus dans celles des seules victimes. En effet, même humiliées, brutalisées, martyrisées, elles conservent leur dignité ou leur fierté.
    Keywords: bande dessinée ; violence sexiste ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC6 Cultural studies: customs and traditions
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    UGA Éditions
    Publication Date: 2024-04-02
    Description: Fraternité d’armes ou mésentente cordiale ? L’alliance francoitalienne dans la Première Guerre mondiale offre encore des aspects peu connus du grand public, tout particulièrement en ce qui concerne la coordination de l’effort de guerre et l’efficacité opérationnelle des appareils militaires des deux puissances latines de l’Entente. Ces questions sont abordées ici par un collectif de spécialistes italiens et français dans une perspective large et dynamique, des antécédents du conflit à ses conséquences (culturelles, sociales, géopolitiques) dans les deux pays. Grâce à des documents et à des témoignages souvent inédits (correspondances, journaux intimes), ce livre offre un nouvel éclairage sur la contribution des acteurs politiques et militaires, mais aussi des ingénieurs et des savants, à la construction d’une alliance certes imparfaite mais somme toute féconde.
    Keywords: Première Guerre mondiale ; mise en mémoire ; Grande Guerre ; aéronautique ; anciens combattants ; couple franco-italien ; bombardements ; Entente ; récits de guerre ; Caporetto ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period) ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPH Political structure and processes::JPHX Political structures: totalitarianism and dictatorship ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSD Diplomacy ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWC Military forces and sectors::JWCK Naval forces and warfare ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWC Military forces and sectors::JWCM Air forces and warfare
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: Over 70% of the Earth’s surface is covered by oceans and seas, which are massively complex and consist of diverse assemblages of life forms. Marine bacteria, fungi, and other microorganisms develop unique metabolic and physiological capabilities that enable them to survive in extreme habitats and to produce compounds that might not be produced by their terrestrial counterparts. In the last few decades, the systematic investigations of marine/marine-derived microorganisms as sources of novel biologically active agents has exponentially increased. This Special Issue will focus on aspects relating to new bioactive metabolites from marine microorganisms including the isolation, taxonomy, and/or dereplication of microorganisms and the corresponding isolation, structure elucidation, biosynthesis, and/or biological activities of the new compounds. Comprehensive topical review articles relating to marine metabolites will also be considered.
    Keywords: co-culture ; marine microbes ; natural products ; structural diversity ; biological activities ; food allergy ; deep-sea-derived viridicatol ; X-ray single crystal ; intestinal barrier ; mast cell ; calcium influx ; Chlorella ; enzymes ; lipases ; molecular modeling ; sulfated polysaccharides ; antiviral ; SARS-CoV-2 ; docking ; molecular dynamic simulations ; sea cucumber ; bioactivity ; diversity ; microorganism ; polyketides ; alkaloids ; marine-derived fungus ; Penicillium sp. ; indole-diterpenoids ; cytotoxicity ; antibacterial activity ; Leizhou Peninsula ; mangrove soil ; actinomycetia ; antimicrobial activity ; secondary metabolites ; dereplication ; metabolomics tools ; trioxacarcins ; mansouramycins ; isoquinolinequinones ; marine-derived Streptomyces sp. ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia.In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells.
    Keywords: pre-eclampsia ; eclampsia ; pulmonary oedema ; biobank ; database ; placental ischemia ; seizure ; ASIC2a ; pregnancy ; RUPP ; pentylenetetrazol ; melatonin ; extracellular vesicle ; exosome ; preeclampsia ; misfold proteins ; endothelial cell activation ; p21Cip1/CDKN1A ; trophoblasts ; hypoxia ; trophoblast organoids ; fusion ; angiotensin II ; AGTR1 (angiotensin II receptor type 1) ; bradykinin ; BDKRB2 (bradykinin receptor B2) ; AT1R-B2R heteromer (protein complex formed of AT1R-B2R) ; G-protein-coupled receptor ; protein aggregation ; ARRB (beta-arrestin) ; early-onset preeclampsia ; hemorheology ; red blood cell aggregation ; red blood cell deformability ; erythrocyte ; hypertension ; IL-2 ; inflammation ; oxidative stress ; sFlt-1 ; NLRP3 ; nitric oxide ; endothelial dysfunction ; neuroinflammation ; blood–brain barrier ; cerebral edema ; gestation ; vessel ; blood pressure ; placenta ; trophoblast ; fetal growth restriction ; maternal chronic venous disease (CVeD) ; anti-inflammation ; antioxidant ; ischaemia ; vitamin E ; glucose transporter 9 ; GLUT9 ; uric acid ; cardiac dysfunction ; placental factors ; activin A ; G-protein-coupled receptors ; GPCR ; weighted gene correlation network analysis ; WGCNA ; blood-brain barrier ; in vitro studies ; cerebral biomarkers ; NfL ; tau ; NSE ; S100B ; nebivolol ; adrenoceptor ; obesity ; biomarkers ; adipokines ; adiponectin ; leptin ; ROS ; angiogenic factors ; hypoxia/reoxygenation ; sFlT-1/PlGF ratio ; primary trophoblast ; bic Book Industry Communication::M Medicine
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-02
    Description: Slavery takes many forms. This was also true in Roman antiquity, even though modern scholarship on Roman slavery paints the picture of a very homogenous institution. This volume intends to correct that perception. In it, renowned legal historians analyse juristic writings to showcase the social differences among slaves reflected in these texts. In this way, the papers collected here convey an impression of the complexity of Roman slave law.
    Keywords: Roman law ; peculium ; slave families ; slave hierarchies ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAB Methods, theory and philosophy of law
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: The human body poses various biological barriers to protect itself from pathogens, foreign materials and is important for its functioning and development. This reprint serves as a collection of research and review articles describing novel approaches and new therapeutic modalities to overcome biological barriers. This collection is a must read for scientists working in the field of drug and vaccine delivery.
    Keywords: blood-brain barrier ; integrity marker ; sorbitol ; positron emission tomography ; focused ultrasound ; zolmitriptan ; intranasal ; bilosomes ; sodium deoxycholate ; mucoadhesive gel ; brain targeting ; blood–brain barrier ; drug formulation ; drug hybrids ; intra-arterial delivery ; intracranial malignancies ; intranasal delivery ; monoterpene ; monoterpenoid ; NEO100 ; carbomer hydrogel ; whitening agents ; enhancers ; enhancement site and mechanism ; drug release and permeation ; inhaled drug delivery ; prodrug ; liposome formulation ; propofol ; micelle ; DSPE mPEG2k ; Solutol HS 15 ; diclofenac ; optimization ; pharmacokinetic ; pharmacodynamic study ; long acting ; sustained delivery ; biologics ; silica microparticles ; exosome ; brain delivery ; BBB crossing ; transcytosis ; peptide-drug conjugates ; blood–placental barrier ; Zika virus ; BBB shuttles ; porphyrins ; antivirals ; epidermal growth factor receptor ; non-small cell lung cancer ; Lamin B2 ; AMPK ; Osimertinib ; RNA seq ; proteomics ; RT-PCR ; blood–brain tumor barrier ; permeabilization ; brain tumors ; primary central nervous system lymphoma ; tumor necrosis factor-alpha ; targeted delivery ; vascular targeting ; CD13 ; TNF ; TNF receptors ; NGR-TNF ; polyamidoamine dendrimers ; diabetic retinopathy ; protein kinase C-β inhibitor ; nanoparticles ; ruboxistaurin ; blood brain barrier ; electropermanent magnet ; magnetic resonance imaging ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    Éditions universitaires de Dijon
    Publication Date: 2024-04-02
    Description: The occupation of Dijon began on 17 June 1940. Very rapidly, numerous Dijon residents initiated the first protest against the defeat, including a family of the Saint-Michel district known as the Grenier-Godards: Alphonse, a soldier during World War I, gassed on the eastern front in 1917; Blanche, a nurse who became involved in September 1939; and their two young sons, René, fifteen, and Jean, eleven. Blanche, who organised the network, instigated secret activities: prisoner escapes, false IDs, crossing the demarcation line, secret services, and helping Jews. The network counted more than 300 members in 1942. A woman, a family, a district. How and why did the French enter the Resistance in the summer of 1940? How did a secret organisation operate at the beginning of this movement? Why was the Grenier-Godard network forgotten after being honoured and rewarded? These are the questions this monograph addresses so that the Dijon network can be rescued from the oblivion of history.
    Keywords: World War II ; resistance movements ; Côte-d’Or ; German occupation ; woman in wars ; childhood and war ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999
    Language: French
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    Amsterdam University Press
    Publication Date: 2024-04-02
    Description: Integration politics in the Netherlands has changed dramatically between 1990 and 2005. Whereas ethnic and religious differences were hitherto pacified through accommodation, a new and increasingly powerful current in Dutch politicsproblematizes the presence of minorities.This development represents a challenge to sociologists and political scientists: how to map and explain drastic changes?Arguing that extant approaches are better at explaining continuity than change, this book develops a distinct approach to the study of dynamic power relations to understand drastic transformations in the national debate as well as urban governance.
    Keywords: Political Science ; Sociology ; History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies
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    Open Press Tilburg University
    Publication Date: 2024-04-02
    Description: Do Europeans really feel European? Do they trust each other and are they solidary? What do they think of immigration and refugee influx? Do they want a greener and more sustainable Europe, and at what cost? Are democracy and human rights ingrained in Europe or are they under pressure? A new edition (2022) of the ‘Atlas of European Values’ answers these and other questions related to pressing topics such as migration, democracy, sustainability, welfare, identity, and solidarity in an attractive, visual way. In the Atlas, the reader will find maps, charts and graphs based on high-quality data of the long-term comparative survey research project, the European Values Study.
    Keywords: European values; European Identity; Welfare; Migration; Sustainability; Solidarity; Democracy ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTP Historical geography::NHTP1 Historical maps and atlases ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSN International institutions ; thema EDItEUR::1 Place qualifiers::1Q Other geographical groupings: Oceans and seas, historical, political etc::1QF Political, socio-economic, cultural and strategic groupings::1QFE EU (European Union) ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNU Sustainability ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RP Regional and area planning
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    Collège de France
    Publication Date: 2023-12-06
    Description: There is, on the one hand, life that flows from a beginning to an end, and, on the other hand, life that constitutes human singularity because it can be recounted. We may term them “biological life” and “biographical life”. Life expectancy measures the length of the former; a life story relates the richness of the latter. Only by acknowledging both can the inequality of lives be comprehended. They should be conceived of as being both distinct and connected: distinct, because the paradox of French women shows that a long life is no guarantee of a good life; connected, because the experience of African-American men stands as a reminder that a devalued life is a damaged life. This also raises the question of refugees and migrants.
    Keywords: society ; health ; public health ; sociology ; social science ; anthropology ; inequality ; life ; social inequality ; life expectancy ; lives ; inequity ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFH Illness & addiction: social aspects ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFJ Social discrimination & inequality ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Based on this evidence, a deep understanding of the immunological status and biological targets modulating immunological microenvironments should be quite informative for the development of future immunotherapy in HCC. From this point of view, this Special Issue will highlight the current state of the art in the immunotherapy of HCC from both the basic and clinical perspectives, and outline future perspectives for improving therapies.
    Keywords: cancer immunotherapy ; TCGA ; mutations ; copy number variations ; microRNAs ; PD-1 ; PD-L1 ; hepatocellular carcinoma ; predictive factors ; immunotherapy ; immune checkpoint inhibition ; check-point inhibitors ; liver disease ; outcome ; biomarkers ; combination immunotherapy ; immune-related adverse events (irAEs) ; hepatocellular carcinoma (HCC) ; alpha fetoprotein response ; immune checkpoint inhibitor ; unresectable hepatocellular carcinoma ; a disintegrin and metalloprotease 9 ; nivolumab ; natural killer ; CTLA-4 ; combination therapy ; PD-1 antibody ; PD-L1 antibody ; anti-VEGF inhibitor ; molecular classification ; immune phenotype ; stem cell marker ; oncogenic signal ; β-catenin ; genetic alteration ; liver cancer ; effectiveness ; safety ; HCC ; molecular-targeted agent ; TACE ; tyrosine kinase inhibitor ; CD14+ cells ; programmed death 1 ligands ; translational approaches ; combination therapies ; therapy resistance ; predictive markers ; tissue-resident memory CD8 T cells ; immune checkpoint blockade ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Inconnu en France, Sergueï S. Averintsev (1937-2004) est, pour le philosophe russo-américain Mikhaël Epstein, « cet éminent connaisseur de la culture russe, dont l’apport est considérable dans de nombreux domaines des sciences humaines : philologie, philosophie, théologie, études littéraires, histoire intellectuelle… ». Personnage de frêle apparence mais de grande séduction, vraie légende de la Russie des années 1970, il est ici présenté dans un contexte caractérisé, sur le plan politique, par la sortie du soviétisme et ses conséquences ; et sur le plan philosophique, par un retour aux sources hellénique et byzantine de la pensée russe. L’auteur fait appel aux témoignages des acteurs de la dissidence politico-culturelle qui, avec Averintsev, ont contribué aux changements de cette période : Lossev, Likhatchev, Mamardachvili, Galtsova, Gasparov, Sedakova. Il souligne combien Averintsev, renouant avec un vaste héritage qui va de l’hellénisme tardif à la poésie de l’Âge d’argent, pose des questions d’aujourd’hui : l’identité européenne et la transmission de l’héritage culturel ; la nécessité et les limites d’une politique conservatrice en réponse aux questions du temps ; l’évolution de la linguistique devenue une approche qui inscrit les sociétés dans une large perspective culturelle ; enfin le rôle de la pédagogie directe dans la transmission du savoir.
    Keywords: philologie ; hellénisme ; dissidence ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    University of Michigan Press
    Publication Date: 2024-04-02
    Description: Many histories of Ancient Greece center their stories on Athens, but what would that history look like if they didn’t? There is another way to tell this story, one that situates Greek history in terms of the relationships between smaller Greek cities and in contact with the wider Mediterranean. In this book, author Joshua P. Nudell offers a new history of the period from the Persian wars to wars that followed the death of Alexander the Great, from the perspective of Ionia. While recent scholarship has increasingly treated Greece through the lenses of regional, polis, and local interaction, there has not yet been a dedicated study of Classical Ionia. This book fills this clear gap in the literature while offering Ionia as a prism through which to better understand Classical Greece. This book offers a clear and accessible narrative of the period between the Persian Wars and the wars of the early Hellenistic period, two nominal liberations of the region. The volume complements existing histories of Classical Greece. Close inspection reveals that the Ionians were active partners in the imperial endeavor, even as imperial competition constrained local decision-making and exacerbated local and regional tensions. At the same time, the book offers interventions on critical issues related to Ionia such as the Athenian conquest of Samos, rhetoric about the freedom of the Greeks, the relationship between Ionian temple construction and economic activity, the status of the Panionion, Ionian poleis and their relationship with local communities beyond the circle of the dodecapolis, and the importance of historical memory to our understanding of ancient Greece. The result is a picture of an Aegean world that is more complex and less beholden narratives that give primacy to the imperial actors at the expense of local developments.
    Keywords: Ionia, Greece, Miletus, Ephesus, Classical Greece, Chios, Samos, History, temples, Alexander the Great, Panionion, Anatolia, Lydia, Peloponnesian War, Delian League, Caria, Mausolus, Didyma, Branchidae, Persia, Tissaphernes, Aspasia, regional history, Ionian League, Ionian Revolt, Artemis, Achaemenid Persia, historical memory, Ancient history, Greek history, Hellenistic Greece ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBB Literary studies: ancient, classical and medieval
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This reprint focuses on land use/land cover (LULC), natural hazards and their interactions, changes, and impacts. Over the past few decades, the risks due to natural hazards have increased significantly, to a large extent due to changes in LULC, which are triggered mainly by anthropic pressure on landscapes, i.e., urbanization, forest management practices, agricultural practices, and the like. As a result, LULC changes contribute significantly to changes in the variability or magnitude of natural hazards, such as floods, landslides, and erosion. Therefore, this reprint provides a collection of studies focused on the interactions between LULC and different types of natural hazards, which were studied in several research areas around the world.
    Keywords: flash floods ; intense rainfall ; urbanized areas ; damage ; anthropic impacts ; West Mediterranean ; Italy ; land use change ; surface runoff ; urban development ; green infrastructure ; Xiamen ; land use/land cover legacy ; airborne LiDAR-based HRDTM ; generalized additive model ; landslide susceptibility modeling ; historical landslide inventory bias ; biomass extraction ; farmers’ perception ; NDVI ; climate change ; remote sensing ; GIS ; NDBI ; flood risk ; land use ; settlement development ; agricultural land use ; flood-prone areas ; Alpine regions ; landslide modelling ; shallow landslides ; soil cohesion ; soil tillage ; river meandering ; river morphology ; centerline migration ; satellite images ; loess ; filled slope ; physical model test ; interface effect ; stability ; river morphodynamics ; Landsat data ; planform changes ; forest fire ; fire danger rating systems ; environmental fire danger ; fire indices ; drought indices ; remote sensing fire indices ; fire ignition probability ; climate change extremes ; land cover ; QGIS ; MOLUSCE ; Great Yellow River Region ; mountain hazards ; land take ; landslide hazard ; land cover change ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Publication Date: 2024-04-02
    Description: In the wake of Russia’s annexation of Crimea and attempt to destabilize eastern Ukraine, the United States will have to reexamine the basic premises of its European policy. The requirement that NATO may have to build a more robust deterrence and defense posture in Eastern Europe would require the Army and Air Force to revisit their planning assumptions that have minimized the U.S. military commitments to the region since the end of the Cold War.
    Keywords: History ; Political Science ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations
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  • 242
    Publication Date: 2024-03-31
    Description: Doctors writing about menopause in France vastly outnumbered those in other cultures throughout the entire nineteenth century. The concept of menopause was invented by Frenchmen medical students in the aftermath of the French Revolution, becoming an important pedagogic topic and a common theme of doctors’ professional identities in postrevolutionary biomedicine. Older women were identified as an important patient cohort for the expanding medicalisation of French society and were advised to entrust themselves to the hygienic care of doctors in managing the whole era of life from around and after the final cessation of menses. However, menopause owed much of its conceptual weft to earlier themes of women as the sicker sex, of vitalist crisis, of the vapours, and of astrological climacteric years. This book is the first comprehensive study of the origins of the medical concept of menopause, richly contextualising its role in nineteenth-century French medicine and revealing the complex threads of meaning that informed its invention. It tells a complex story of how women’s ageing featured in the demographic revolution in modern science, in the denigration of folk medicine, in the unique French field of hygiène, and in the fixation on women in the emergence of modern psychiatry. It also reveals the nineteenth-century French origins of the still-current medical and alternative-health approaches to women’s ageing as something to be managed through gynaecological surgery, hormonal replacement, and lifestyle intervention.
    Keywords: history of menopause, French medical history, French women’s history, history of women’s ageing, women as patients in modern biomedicine, gendered medical concepts ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Musculoskeletal research deals with the effects of the orthopedic treatment of pathologies on the biomechanics of the affected areas and on the musculoskeletal system. Biomechanical measurement methods enable the quantitative determination of these influences and allow for an assessment of their extent and size for the patient (in vivo). The range of examination methods is particularly wide in this field of musculoskeletal research. On the one hand, in vitro examinations under laboratory conditions on simplified models, such as artificial bones or specimens from donors, will be implemented. With the help of these models, for example, new biomaterials or implants for the treatment of fractures are often examined for their primary stability or the influence of a joint replacement on the kinematics. In contrast to experimental in vitro studies, numerical methods will be increasingly applied to analyze a large number of implant configurations and loading scenarios. With the method of clinical motion analysis, a comprehensive view of the musculoskeletal system is performed directly in vivo on the patient. For example, it allows for the monitoring and control of therapeutic interventions. These are just a few examples from the field of musculoskeletal research and its methods. They all have the common goal of increasing patient safety. This Special Issue intends to provide the reader with an exciting overview of current research in the field of biomechanical investigations for the treatment of musculoskeletal diseases.
    Keywords: motion analysis ; kinematics, repeatability ; lower extremity ; optical infrared camera motion capturing system ; proximal femoral varization osteotomy ; blade plate ; screw side plate ; cervical spine surgery ; allograft spacer ; subsidence ; finite element model ; knee osteoarthrosis ; surgery ; posturography ; postural subsystems ; pain ; quality of life ; glycogenosis type II ; acid maltase deficiency ; enzyme replacement therapy ; balance ; lateral mass ; pedicle screws ; leg alignment ; unilateral hip osteoarthritis ; gait analysis ; joint loading ; external joint moments ; reliability ; model-based RSA ; elementary geometrical shape models ; accuracy ; hip arthroplasty ; migration ; gonarthritis ; meniscus ; articular cartilage ; biomechanical testing ; mapping ; indentation ; instantaneous modulus ; tissue biomechanics ; partial threading ; fatigue life ; biomechanical analysis ; spinal fixation ; knee joint kinematics ; wear bearing ; rolling-sliding mechanism ; test bench ; cement-in-cement ; revision ; aging cement ; joint arthroplasty ; cement ; bending strength ; joint replacement ; hip joint ; range of motion ; impingement ; TKA ; wear simulator ; ISO standard ; FEM ; finite element ; supracondylar humeral fracture ; biomechanical study ; sagittal pinning ; Kirschner wires ; digital templating ; short-stem ; lateral view ; femoral torsion ; hip deformity ; femoroacetabular impingement (FAI) ; heel strike ; toe off ; carbon dioxide lavage ; pulsatile lavage ; bone preparation ; total knee arthroplasty ; total hip arthroplasty ; polyethylene wear ; roentgen stereophotogrammetric analysis ; precision ; pelvic orientation ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-02
    Description: Providing a novel research methodology for students and scholars with an interest in dynasties, at all levels, this book explores the Spanish Habsburg dynasty that ruled the Spanish monarchy between c. 1515 and 1700. Instead of focusing on the reigns of successive kings, the book focuses on the Habsburgs as a family group that was constructed in various ways: as a community of heirs, a genealogical narrative, a community of the dead and a ruling family group. These constructions reflect the fact that dynasties do not only exist in the present, as kings, queens or governors, but also in the past, in genealogies, and in the future, as a group of hypothetical heirs. This book analyses how dynasties were ‘made’ by the people belonging to them. It uses a social institutionalist framework to analyse how family dynamics gave rise to practices and roles. The kings of Spain only had limited power to control the construction of their dynasty, since births and deaths, processes of dynastic centralisation, pressure from subjects, relatives’ individual agency, rivalry among relatives and the institutionalisation of roles limited their power. Including several genealogical tables to support students new to the Spanish Habsburgs, this book is essential reading for all students of early modern Europe and the history of monarchy.
    Keywords: Dynastic Rule;dynastic centralisation;family dynamics;Spanish Habsburg;Spanish monarchy ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history
    Language: English
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    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Dans l’entre-deux-guerres, Hong Kong est déjà une ville-monde, un emporium où transitent les marchandises venues de tous les continents, un port franc où commencent et s’achèvent les grandes lignes maritimes, une colonie britannique où s’entrechoquent les existences et, parmi celles-ci, des Françaises et des Français. À Hong Kong, la France est d’abord officiellement représentée par un consulat. Autour de cette sphère gravitent des acteurs aux statuts formels qui participent à l’essor des intérêts français. Maisons de négoce, compagnies maritimes, établissements bancaires ou encore congrégations religieuses ont des besoins similaires : se développer à partir d’un environnement stable, puis rayonner en Asie orientale. Ces groupes ne reflètent toutefois qu’une partie de la communauté française. Des présences marginales s’ajoutent, éphémères, interlopes, rebelles ou simplement jugées insignifiantes. Tous ces éléments sont liés. Leurs interactions tissent la trame d’une société hybride dont les perceptions diffèrent de celles de leurs compatriotes restés en métropole. Ce tableau de la France à Hong Kong interroge les nombreuses réalités de la notion de présences – celles-ci pouvant également être désincarnées, voire immatérielles – et questionne ce qui conduit des Français hors de leur empire. La colonie britannique est un observatoire privilégié pour étudier ces réseaux et les acteurs qui les animent.
    Keywords: Français de l'étranger ; Indochine ; influence ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: COVID-19 is the most prominent and rapidly evolving public health concern in the world currently. The gastrointestinal manifestations of COVID-19 are increasingly being recognized. SARS-CoV-2 infection has been associated with the occurrence of nausea, vomiting, and diarrhea. SARS-CoV-2 has also been causing pancreatic and hepatic injury. Emerging data have shown that COVID-19 patients continue to shed the virus into their stools, even when patients test negative for COVID-19 in pulmonary secretions. However, the epidemiology, pathogenesis, and treatment of SARS-CoV-2-related gastrointestinal manifestations are poorly understood. The pandemic has also had a significant impact on gastroenterologists, endoscopists, and other ancillary staff. Moreover, in the past, systematic respiratory virus syndrome (SARS) was shown to be transmitted by endoscopes, which is a big concern with COVID-19, as it shares many pathological features with SARS. The deferral of elective endoscopic procedures has negatively affected gastroenterologists. This Special Issue focuses on the current situation of this pandemic. It aims to provide insight into the gastrointestinal manifestations of COVID-19 and its effects on endoscopic procedures. I believe that this issue will be beneficial not only for gastroenterologists but also other healthcare workers around the world to recognize the often-ignored clinical gastrointestinal manifestations of COVID-19.
    Keywords: COVID-19 ; liver ; non-alcoholic steatohepatitis ; transient elastography ; mortality ; liver disease ; clinical manifestations ; SARS-CoV-2 ; gastroenterology ; hepatology ; endoscopy ; delivery of healthcare ; acute mesenteric ischemia ; thromboemboembolism ; endothelitis ; cytokines ; hypercoagulability ; inflammatory bowel disease ; gastrointestinal manifestations ; abdominal pain ; dyspnea ; clinical course ; upper gastrointestinal bleeding ; pandemic ; outcomes ; anxiety ; depression ; medication adherence ; severity of COVID-19 ; hospitalized patients ; risk factors ; SARS-CoV-2 infection ; gut dysbiosis ; microbiota ; gastrointestinal disorders ; intestinal inflammation ; ACE2 dysregulation ; gut microbiota ; enteric infection ; bic Book Industry Communication::M Medicine
    Language: English
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    University of New Orleans Press
    Publication Date: 2024-04-02
    Description: After the dissolution of the Austro-Hungarian Monarchy, Austria transformed itself from an empire to a small Central European country. Formerly an important player in international affairs, the new republic was quickly sidelined by the European concert of powers. Austria's post-Habsburg state suffered from enormous losses of territory and population. However, these losses did not hamper the country's innovative spirit. The essays in this twentieth anniversary volume of Contemporary Austrian Studies argue that Austria found its place in the global arena of the twentieth century, making its mark on both Europe and the world. From Freudian psychoanalysis to Auto-Marxist thought and the Austrian School of Economics, Austrian ideas continued to be vital to the intellectual community at large. Vienna remained the Austrian capital and reasserted its strong position in Central European and international business and finance. This volume also examines how increasing globalization in the 20th century impacted Austrian demography, society, and political life. Specifically, the essays discuss how Austria's place in the contemporary world became increasingly determined by the European integration process.
    Keywords: History ; Political Science ; European Studies ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The Special Issue titled “Recent Advances in Long-Acting Drug Delivery and Formulations” encompasses versatile and innovative research domains of oral, ocular, brain, and topical delivery systems and chemical approaches (e.g., prodrugs), highlighting the progress made in identifying excipients (e.g., basic amino acids to ameliorate gastric side effects of non-steroidal anti-inflammatory drugs (NSAIDs)), polymers, and molecular targets to achieve more effective sustained release systems and safer medicine. In this Special Issue, 78 authors have contributed, with eleven original research articles spanning five continents (Asia, Europe, Africa, North America, and Australasia) providing important insights into the pharmaceutical sciences.
    Keywords: drug delivery ; nanotechnology ; alzheimer’s disease ; Amyloid-β ; solid lipid nanoparticles ; SHSY5Y cells ; altretamine ; cancer therapy ; sustained delivery ; hydroxyapatite nanoparticles ; chemical precipitation method ; polymeric film ; diabetes mellitus ; skin regeneration ; wound healing ; sodium alginate ; sodium carboxy methyl cellulose ; microwave ; cross-linking ; ketoprofen ; L-arginine ; L-lysine ; tris ; basic amino acids ; writhing ; gastric ulcer ; chitosan ; 1,3,5-benzene tricarboxylic acid ; hydrogels ; rheology ; alginate ; BSA ; Maillard reaction ; age-related-macular degeneration ; drug release ; fenofibrate ; retinal cells ; HIV ; long-acting subcutaneous injection ; raltegravir ; cyclisation-activated prodrugs ; β-blockers ; NSAIDs ; corticosteroids ; ocular delivery ; drug permeability ; QSPR ; MLR ; Alzheimer’s disease ; GSK-3β-Wnt/β-catenin ; PERK/CHOP/Bcl-2 ; oxidative stress ; cocoa ; vinpocetine ; diabetes ; salbutamol ; skeletal muscle atrophy ; sarcosine ; metabolomics ; factorial design ; controlled release ; topical delivery ; texture analysis ; bioadhesion ; intermolecular interactions ; hydroxypropyl methylcellulose ; polyvinylpyrrolidone ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    Cornell University Press | Cornell University Press
    Publication Date: 2024-04-07
    Description: Danna Agmon's gripping microhistory is a vivid guide to the "Nayiniyappa Affair" in the French colony of Pondicherry, India. The surprising and shifting fates of Nayiniyappa and his family form the basis of this story of global mobilization, which is replete with merchants, missionaries, local brokers, government administrators, and even the French royal family. Agmon's compelling account draws readers into the social, economic, religious, and political interactions that defined the European colonial experience in India and elsewhere. Her portrayal of imperial sovereignty in France's colonies as it played out in the life of one beleaguered family allows readers to witness interactions between colonial officials and locals. Thanks to generous funding from Virginia Tech and its participation in TOME, the ebook editions of this book are available as Open Access volumes from Cornell Open (cornellpress.cornell.edu/cornell-open) and other repositories.
    Keywords: Pondicherry, colonialism, trade, missionaries, intermediaries, The Nayiniyappa Affair ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-27
    Description: This open-access book investigates Francophone Caribbean literature by exploring and analyzing French seventeenth-century travel writings. The book argues for a literary re-examination of the representation of the early colonial Caribbean by proposing theoretical linkages to contemporary Caribbean theories of creolization and archipelagic thinking. Using Édouard Glissant’s notion of points of entanglement, Christina Kullberg claims that the historical, social, and political messiness of the Caribbean seventeenth century make for complex representations and expressions, generating textual instability despite the travelers’ apparent desires to domesticate the islands. Taking a synoptic approach to travel narratives in French from 1620 up to the publication of Labat’s Nouveau voyage aux Isles de l’Amérique in 1722, Kullberg examines textual instances where the islands and the peoples of this period disrupt and unsettle dominant French narratives and enter productively into the construction of knowledge and the representations of the region. Kullberg’s contribution is to read French early modern travels in situ as shaped by the archipelagic geography, its history and social formations in order to interrogate both the construction and the limitations of discourses of power.
    Keywords: travel writing ; Caribbean literature ; French seventeenth-century travelogues ; Francophone Caribbean ; Édouard Glissant ; baroque period ; archipelagic ; colonialism ; geography ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBH Literary studies: c 1900 to c 2000::DSBH5 Literary studies: postcolonial literature ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
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    RAND Corporation
    Publication Date: 2024-04-02
    Description: This report discusses the 2013 French Army operations in Mali (Operation Serval) to provide a model for an expeditionary force that has attributes and competencies the United States Army seeks. The French demonstrated that they are adept at fielding small yet capable forces tailored for specific objectives and reiteratively task organizing as the situation evolves. They also have a culture and force structure geared for expeditionary operations.
    Keywords: History ; Technology ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence::JWK Military and defence strategy ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTM Military engineering
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    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Hippolyte Luc (1883-1946) est l’un des bâtisseurs de l’enseignement technique et professionnel français. Orphelin de l’Assistance publique devenu agrégé de philosophie puis haut fonctionnaire, sa trajectoire emblématique de la méritocratie républicaine est celle d’un « transclasse » pétri de doutes et d’ambivalences. Directeur général de l’enseignement technique de 1933 à 1944 dont il a théorisé le rôle dans le développement d’une économie moderne, Luc a puissamment contribué à développer le réseau d’écoles publiques de formation technique et professionnelle, à instituer les diplômes d’État comme critères de qualification et de rémunération des salariés, et il a été un des pionniers de l’orientation. Resté à son poste jusqu’en juillet 1944, authentiquement anti-nazi, Luc n’a pas collaboré avec les autorités allemandes, ni manifesté d’opinion antisémite, mais ne s’est pas davantage engagé dans une action résistante. Au prix d’une compromission avec un gouvernement dont les choix politiques étaient à l’opposé de ses convictions, il a obstinément poursuivi l’accomplissement de ce qu’il considérait comme l’œuvre de sa vie : bâtir un enseignement technique au service du peuple et du pays. En se plaçant au croisement de l’histoire intime et de l’histoire collective, ce livre apporte ainsi des éclairages inédits sur l’histoire scolaire, sociale et politique de la France contemporaine.
    Keywords: enseignement professionnel ; enseignement technique ; histoire de l'enseignement ; méritocratie ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Many cancer diagnosis and treatment modalities have been developed over time, among which radioisotopes have been widely used. Recently, with the application of magnetic nanoparticles, a wide range of non-invasive diagnosis and treatment methods using magnetic techniques have attracted attention. This Special Issue introduces a lymph node biopsy method with a magnetic probe for the treatment of cancer, rapid immunostaining using magnetic nanoparticles in pathological diagnosis, cancer imaging with MRI (magnetic resonance imaging)/MPI (magnetic particle imaging), magnetic hyperthermia for cancer treatment, and the development of magnetic nanoparticles.
    Keywords: nonpalpable breast lesion ; breast cancer ; magnetic maker ; magnetic probe ; surgery ; nanomedicine ; superparamagnetic iron oxide nanoparticles (SPIONs) ; adoptive T cell transfer ; immune therapy ; targeted transport ; solid tumor ; magnetic targeting ; sentinel lymph node biopsy ; superparamagnetic iron oxide ; magnetic tracer ; sentinel lymph node ; magnetism ; cancer ; tumor ; in vitro ; metastatic cascade ; review ; hyperthermia ; magnetic hyperthermia ; magnetic nanoparticles ; magnetic nanoparticle-induced biological effects ; clinical trial ; new therapies ; sentinel lymph node dissection ; super paramagnetic iron-oxide particles ; rat model ; magnetic technique ; superparamagnetic nanoparticles ; cancer cell photothermal therapy ; surface charge targeting ; folic acid targeting ; vitamin E TPGS modification ; magnetic particle imaging ; magnetic drug delivery ; prostate cancer ; lymphadenectomy ; metastases ; superparamagnetic iron oxide nanoparticles ; radioisotopes ; in situ diagnosis ; rapid detection ; extracellular vesical quantification ; presurgical screening ; pathological diagnosis ; sentinel node mapping ; neoadjuvant chemotherapy ; SPIO ; radioisotope ; oral cancer ; superparamagnetic iron oxide (SPIO) ; tracer distribution ; MRI ; lymphography ; histopathology ; grading system ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint focuses on new trials related to cataract surgery, intraocular lens power calculations for cataracts after refractive surgery, problems related to high myopia, toric IOL power calculations, etc. Intraoperative use of the 3D Viewing System and OCT, studies on the spectacle dependence of EDOF, IOL fixation status and visual function, and dry eye after FLAC are also discussed. Proteomic analysis of aqueous humor proteins is also discussed.
    Keywords: aqueous humor ; label free ; cataract ; risk factor ; proteomics ; alpha-2-HS-glycoprotein ; fetuin-A ; IOL power calculation after LASIK ; no-history method ; cataract surgery ; anterior–posterior ratio of the corneal radius of the curvature ; axial length ; conditional process analysis ; effective lens position ; intraocular lens power calculation ; tilted microscope positions ; 3D viewing system ; patients unable to lie flat ; n/a ; toric intraocular lens ; cataract surgery workflow ; efficiency ; refractive surgery ; refractive lens exchange ; clear lens exchange ; visual quality ; contrast sensitivity ; scleral fixation ; intraocular lens ; anterior segment OCT ; intraoperative OCT ; surgical technique ; SMILE ; IOL calculation ; ray tracing ; artificial intelligence ; EDOF ; presbyopia ; multifocal lens ; photic phenomena ; IOL accuracy ; high myope ; high axial length ; Caucasian ; Kane ; Barrett ; EVO ; Hill-RBF ; Holladay 1 ; SRK/T ; dry eye ; femtosecond laser-assisted cataract surgery (FLACS) ; phacoemulsification ; cornea ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
    Language: English
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    Manchester University Press
    Publication Date: 2024-04-08
    Description: As part of the United Kingdom’s response to the escalating HIV/AIDS crisis during the 1980s, special wards and community-based services were established to care for people living with HIV/AIDS (PWHA).  Much of the pioneering and innovative care developed at these centres can be attributed to nurses. However, UK nursing history has hitherto neglected to tell their stories. This chapter rectifies this omission by drawing on a wealth of source material including previously unseen, enlightening, and frequently moving oral histories, as well as archival and news media sources, to explore the actions and perceptions of the UK nurses who cared for PWHA, alongside the reflections of PWHA and their loved ones who received this care. 〈br /〉This chapter reveals how assertive PWHA took control of their own care, often becoming experts on their condition – a phenomenon that challenged ideas of medical paternalism by reclaiming decision-making power in the name of the patient.  We explore questions of ethics and socialisation by analysing how nurses were similarly tasked with deciding what actions were permissible in times of crisis – decisions made along the frequently blurred lines that this crisis drew between private and professional lives. Appreciating the personal draw that HIV/AIDS care had to nurses who identified as queer in particular, and the sense of duty this often evoked, offered a meaningful way of interpreting the research gathered for this chapter.  Last, this makes an important contribution to the documented history of nurses’ experiences and constructions of the care of individuals belonging to stigmatised groups.
    Keywords: nurses; HIV/AIDS; expert by experience; nursing history; responsible subversion; stigma; courtesy stigma; oral history; activism; queer ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases::MJCJ2 Medicine: HIV/AIDS, retroviral diseases ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPQ Later 20th century c 1950 to c 1999 ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MR 21st century, c 2000 to c 2100 ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    University of Toronto Press
    Publication Date: 2024-04-02
    Description: In the eighteenth and nineteenth centuries, the Russian empire opened the grasslands of southern Ukraine to agricultural settlement. Among the immigrants who arrived were communities of Prussian Mennonites, recruited as "model colonists" to bring progressive agricultural methods to the east. The three volumes of Transformation on the Southern Ukrainian Steppe document the Tsarist Mennonite experience through the papers of Johann Cornies (1789–1848), an ambitious and energetic leader of the Mennonite colony of Molochna. This volume covers the years between 1836 and 1842, beginning with the creation of the Mennonite Agricultural Society and ending with the Warkentin Affair, which pushed the Mennonite settlement to the precipice of potential religious and political disaster. Throughout this era, Johann Cornies negotiated a shifting political landscape while guiding his community through equally challenging economic times. Cornies was well connected in the imperial government, and his papers offer a window not just into the world of the Molochna Mennonites, but also into the Tsarist state’s relationship with the national minorities of the frontier: Mennonites, Doukhobors, Nogai Tatars, and Jews. This selection of his letters and reports, translated into English, is an invaluable resource for scholars of all aspects of life in Tsarist Ukraine and for those interested in Mennonite history.
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Central European University Press
    Publication Date: 2024-04-02
    Description: The proclamation of Belarusian independence on March 25, 1918, and the rival establishment of the Soviet Belarusian state on January 1, 1919, created two distinct and mutually exclusive national myths, which continue to define contemporary Belarusian society. This book examines the processes that resulted in this dual resolution in the context of World War I and the subsequent Russian Revolutions. Based on original archival material, Lizaveta Kasmach scrutinizes the development of competing concepts of Belarusian nationhood in the context of rivaling national aspirations and imperial policies. The analysis convincingly demonstrates the divisions within the nationalist movement, both politically between the moderates and socialists, and geographically between German-occupied territory with Vilna as a center versus Russian-controlled territory around Minsk. Besides the case study of Belarusian nation-building efforts, the book is a contribution to the study of the First World War in East Central Europe, approaching the war and its aftermath as a mobilizational moment in the region.
    Keywords: Belarus; Nation-Building; Empire; Nationalism; War; Borderlnds; Eastern Europe ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPF Political ideologies and movements::JPFN Nationalism ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history::NHWR Specific wars and campaigns::NHWR5 First World War ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999::3MPB Early 20th century c 1900 to c 1950::3MPBF c 1910 to c 1919::3MPBFB c 1914 to c 1918 (World War One period)
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Several factors have been identified as interfering with the success, rehabilitation, and fitness of athletes from childhood to adulthood, as well as in para-sport, and special populations, according to research. The performance and health of this population are affected by the relationships between stress, maturation, training load, and recovery. Environmental approaches aim to increase efficiency and physiological adaptations in this sense. In various situations and conditions, however, this stimulus–performance–adaptation relationship varies.As a result, we received contributions related (but not limited) to the following topics: training load monitoring; stress and physiological responses during exercise or sports; recovery process after exercise; changes after stress and/or training load; physiology of training in health and sports performance.
    Keywords: visceral adipose tissue ; military ; metabolic syndrome ; cut-off points ; DXA ; warm-up ; muscle force ; performance ; resistance training ; thermal imaging ; physiology ; backstroke ; breaststroke ; start ; sink ; cortisol ; people with disabilities ; physical activities ; South Korea ; social determinants of health ; focus group interviews ; Paralympic Games ; Tokyo 2020 ; sociodemographic ; well-being ; resilience ; social support ; athletes ; disability ; performance indicators ; sports ; footwork ; reaction time ; agility ; physical activity environment ; relative importance ; priority ; pro bono ; intention ; pre-service physical activity instructor ; theory of planned behavior ; leisure time physical activity ; volunteering ; swimming ; social inclusion ; adapted physical activity ; respite care ; altitude ; hemoglobin ; erythropoietin ; hypoxia ; maximum volume of oxygen ; para powerlifting ; athletes with disabilities ; scoping review ; PAGER framework ; bibliometrics ; physical fitness ; body composition ; health ; measurement ; Down syndrome ; load-velocity relationship ; autoregulation ; load monitoring ; fixed-loading ; Wingate anaerobic performance ; paralympic sport ; para-rowing ; bibliometric analysis ; back pain ; sport ; sleep deficiency ; aerobic exercise ; oxidative stress ; hs-CRP ; stress ; hormones ; salivary glands ; endocrine ; autonomic nervous system ; immune system ; disabled athletes ; infection ; lymphocytes ; cytokines ; narrative review ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences::MFG Physiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This collection of articles provides an overview of the current and future methods for applying a personalized medicine approach to the diagnosis, management, and treatment of autism spectrum disorder.
    Keywords: fecal metabolites ; ASD ; microbiome ; gastrointestinal symptoms ; Fisher Discriminant Analysis ; digital biomarkers ; wearables ; time series analysis ; autism ; social dyads ; socio-motor parameters ; network connectivity ; non-linear complex dynamics ; stochastic analysis ; autism spectrum disorders ; copy number variants ; females ; Array-Comparative Genomic Hybridization (Array-CGH) ; autism spectrum disorder ; Ehlers-Danlos syndrome ; hypermobility spectrum disorders ; autonomic disorder ; mast cell activation syndrome ; genetic testing ; chromosomal microarray analysis ; whole exome sequencing ; whole genome sequencing ; clinical utility ; polygenic risk scores ; Temple Grandin ; biomarker ; omics ; precision medicine ; proteomics ; transcriptomics ; epigenetics ; metabolomics ; patient stratification ; mitochondria ; oxidative stress ; prenatal environment ; immune dysfunction ; immunoglobulin G ; intravenous immunoglobulin ; energy metabolism ; fatty acid oxidation ; acyl-carnitines ; resveratrol ; integrative ; model ; concomitant ; condition ; disorder ; autism spectrum disorder (ASD) ; genomics ; personalized treatment strategy ; single nucleotide polymorphisms ; clinical decision support tool ; ADHD ; PANDAS ; OCD ; anxiety ; folate receptor alpha ; folates ; pregnancy ; brain development ; fetal development ; cobalamin ; glutathione ; methylation ; methylcobalamin ; redox metabolism ; locked-in network syndrome ; resting-state functional magnetic resonance imaging ; temporal lobe epilepsy ; amygdala ; brain ; COVID-19 ; children ; cytokines ; flavonoids ; inflammation ; luteolin ; mast cells ; microglia ; SARS-CoV-2 ; stress ; nutraceuticals ; survey ; vitamins ; minerals ; B12 ; folinic acid ; quality of life ; parents ; intervention ; systematic review ; medical claims ; logistic regression analysis ; retrospective analysis ; associated risk ; monoamine neurotransmitters ; neurotransmitter deficiency ; cerebral folate deficiency ; folate receptor alpha autoantibodies ; leucovorin ; α-amylase ; cortisol ; heart rate variability ; neuromodulation ; sleep anxiety ; transdermal electrical neuromodulation ; neurostimulation ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 260
    Publication Date: 2023-11-17
    Description: Magnetic resonance imaging of the brain and spinal cord in patients with multiple sclerosis is crucial for diagnosis as well as monitoring and predicting disease activity. Comprehensive MR measurements including assessment of brain and spinal cord volume changes have the potential to improve patient monitoring, allow earlier detection of subclinical disease activity, and identify patients with depleted brain reserve who are at highest risk of disability progression. Cerebral atrophy measurements are now a secondary outcome of many clinical trials, although their wider use in routine clinical practice is still hampered by some technical limitations. However, evidence from clinical practice shows that assessment of brain and spinal cord volume change is feasible and has the potential to improve patient treatment.
    Description: Published
    Keywords: multiple sclerosis ; brain atrophy ; diagnosis ; measurements ; disease ; monitoring ; magnetic resonance ; cerebral atrophy ; bic Book Industry Communication::M Medicine
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  • 261
    Publication Date: 2024-04-04
    Description: This open access book offers an entangled history of hygiene by showing how knowledge of purity, health and cleanliness was shaped by evangelical medical missionaries and their encounters with people in West Africa. By tracing the interactions and negotiations of six Basel Mission doctors, who practised on the Gold Coast and in Cameroon from 1885 to 1914, the author demonstrates how notions of religious purity, scientific health and colonial cleanliness came together in the making of hygiene during the age of High Imperialism. The heyday of evangelical medical missions abroad coincided with the emergence of tropical medicine as a scientific discipline during what became known as the Scramble for Africa. This book reveals that these projects were intertwined and that hygiene played an important role in all three of them. While most historians have examined modern hygiene as a European, bourgeois and scientific phenomenon, the author highlights both the colonial and the religious fabric of hygiene, which continues to shape our understanding of purity, health and cleanliness to this day.
    Keywords: Switzerland ; Hygiene ; Cleaniness ; Colonial medicine ; Medical missionaries ; West African history ; Cameroon ; Gold Coast ; Basel ; Religious purity ; High Imperialism ; Tropical medicine ; Evangelical missions ; Scramble for Africa ; History of science ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAX History of religion ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This Special Issue of Nutrients is addressing the topic ‘Nutrition, Diet and Food Allergy’. Globally, food allergy affects 1.5% of adults and 5% of children and this prevalence is increasing in recent decades, representing a public health problem. Different mechanisms are involved in food allergic diseases with distinctive clinical characteristics: IgE-mediated and non-IgE-mediated phenotypes will be distinguished in the Issue, considering the early recent literature on the prevalence, age of onset, follow-up recommendations and duration of food allergies. Moreover, the management of these fascinating diseases will be discussed with particular attention on nutritional hazards, risks of allergic reactions to new allergens, problems with missed labelling (precautionary allergen labelling (PAL)). Especially, the dietary restrictions and the re-introduction of allergens lead to a significant burden for affected patients, fear of accidental ingestions and related risk of severe reactions, resulting in a reduced quality of life among patients with food allergies.
    Keywords: nutrients ; infant gut microbiome ; pregnancy ; vegetables ; fruits ; atopic dermatitis ; dysbiosis ; food allergy ; gut ; infants ; microbiota ; skin ; 16S rRNA sequencing ; allergy ; anemia ; cow’s milk ; children ; immunology ; non-IgE-mediated food allergy ; pneumonia ; pulmonary hemosiderosis ; pulmonary infiltrates ; nut allergy ; oral food challenge ; peanut ; prick by prick ; serum specific IgE ; skin prick test ; tree nut ; milk allergy ; non-IgE mediated CMA ; food protein-induced enterocolitis syndrome ; FPIES ; labelling ; prevention ; proteomics ; mass spectrometry ; cow’s milk allergy ; food hypersensitivity ; gastrointestinal disorder ; non-IgE-mediated food hypersensitivity disorder ; wheat allergy ; anaphylaxis ; epinephrine ; schools ; scoping review ; teachers ; peach allergy ; molecular allergy ; Pru p 3 ; Pru p 7 ; peamaclein ; oral allergy syndrome ; pollen-food allergy syndrome ; oral immunotherapy ; undeclared allergens ; pediatric ; food allergies ; risk ; RASFF ; bic Book Industry Communication::M Medicine
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    Presses de l’Université Toulouse Capitole
    Publication Date: 2024-04-02
    Description: Annoncée comme une révolution, la Loi organique relative aux lois de finances (LOLF) du 1er août 2001 marquait alors une rupture. Passant d’une logique de moyens à une logique de résultats, il s’agissait de renouveler les pratiques financières de l’État et des acteurs de la gestion financière. La démarche de performance devait guider l’action de l’État comme désormais des nouveaux opérateurs de l’État. Le contrôle parlementaire devait évoluer et devenir effectif. Vingt ans après sa promulgation et face à la crise toujours permanente des finances publiques, la LOLF a-t-elle atteint ses objectifs ? Comment a évolué le rôle du Parlement depuis 2001 ? La démarche de performance guide-t-elle vraiment l’action de l’État ? Comment ont évolué les principes budgétaires ? L’intégration des finances de l’État avec les autres secteurs des finances publiques a-t-elle connu des avancées ? De multiples questions se posent aujourd’hui quant à l’avenir de la LOLF et de ses perspectives de réformes. Le colloque organisé par l’Institut Fédératif de Recherche « Mutation des normes juridiques », l’Institut Maurice Hauriou et la Société Française de Finances publiques (avec le soutien de la Faculté de droit de Toulouse et de l’Institut Universitaire Champollion d’Albi) se propose de participer à cette vaste réflexion sur les institutions financières de la France.
    Keywords: contrôle ; crise ; réforme ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    University of London Press
    Publication Date: 2024-04-02
    Description: The office of the poet laureate of Britain was a highly prominent, relevant and respectable institution throughout the long eighteenth century. First instituted for John Dryden in 1668, the laureateship developed from an honorific into a functionary office with a settled position in court (c.1689-1715), and was bestowed upon Robert Southey in 1813, whose tenure eventually transformed the office. Taking an interdisciplinary approach, this book examines the office's institutional changes and public reception, the mechanics of each laureate's appointment, and the works produced by the laureates before and after their appointments. It argues that the laureateship played a key part in some of the most vital trends in eighteenth-century culture. The conclusion is arrived at by employing a new research paradigm that it calls the conceptual geography of culture. It shows that Britons routinely used spatial concepts to understand culture throughout the period, which became increasingly abstract over time. As part of this, the court evolved from a concrete space in London to an abstract space capable of hosting the entire British public. The laureateship was a dynamic office positioned at the interface of court and public, evolving in line with its audiences. An important intervention in eighteenth-century historiography, this book presents a nuanced understanding of eighteenth-century culture and society, in which the laureateship exemplified the enduring centrality of the court to the British conceptual geography of culture.
    Keywords: History ; British Studies ; European Studies ; Language & Literature ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general::CBV Creative writing and creative writing guides
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    Casa de Velázquez
    Publication Date: 2024-04-02
    Description: Bartolomé Bennassar est un voyageur. Le temps et l’espace sont ses horizons : la profondeur historique de l’histoire espagnole, les grandes terres de l’Amérique latine. Comme tout pérégrinant, il écrit ses voyages, mais avec une plume double : celle de l’écriture romanesque - l’un de ses romans a connu une adaptation au cinéma - et celle de l’historien. Il nous livre dans ce petit ouvrage la quintessence d’un itinéraire humain et intellectuel : de la découverte de la discipline qui sera la sienne, l’histoire, à sa carrière, scandée au rythme de la publication d’une œuvre historiographique importante, de spécialiste attentif des évolutions du monde hispanique, sans oublier la passion de l’enseignement qui inlassablement l’emmène avec ses étudiants sur les routes des Andes.
    Keywords: historiographie ; Espagne ; Valladolid ; Braudel ; mémoires ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Terrestrial and marine environments are inexhaustible sources of compounds and active extracts which have been employed in medicine since ancient times. The aim of this reprint is to collect new approaches around compounds and extracts isolated from natural products and their biological activity, with a focus on anti-inflammatory pathways. Thus, this reprint compiles full original papers and reviews articles published during 2023 in a Special Issue of Life, titled “Inflammation and Natural products”. The publications within this reprint are focused on secondary metabolites of plants demonstrating significant antioxidants and anti-inflammatory properties, among others, and clinical relevance in various pathological conditions. It also includes reviews that focus on natural therapies for topics such as arthritis, lung diseases, neuroprotection, skin photoprotection, and the impact of gender in the use of medicinal plants in relation to vascular diseases. The reprint of this Special Issue will serve as a reference text for researchers and academics, as well as those studying natural products and their pharmacological activities.
    Keywords: Laurus nobilis ; Arbutus undeo ; volatile compounds ; anti-diabetic ; anti-inflammatory ; antimicrobial ; Ziziphus jujuba leaves ; rutin ; quercetin ; chlorogenic acid ; lipophilic ointment ; healing activity ; anti-inflammatory properties ; Alzheimer’s disease ; biflavonoids ; ginkgetin ; neuroprotection ; ginkgo ; vascular dysfunction ; endothelium ; plant extracts ; gender ; safety ; botanicals ; garlic ; traditional medicine ; ethnopharmacology ; hesperidin ; inflammation ; respiratory lung diseases ; flavonoids ; usnic acid ; enantioselective ; plumbagin ; plumbaginaceae ; natural compound ; antioxidant ; antibacterial ; antiparasitic ; anti-senescence ; stem cells ; Polypodium leucotomos ; Fernblock® ; photoprotection ; photodermatoses ; photoaging ; hyperpigmentation ; rheumatoid arthritis ; triterpenes ; celastrol ; betulinic acid ; ginsenosides ; saponins ; essential oils ; Melissa officinalis ; oregano ; lavender ; Chios Mastic (Mastiha) ; glucocorticoid receptor ; anti-inflammatory actions ; apoptosis ; anti-hyperglycemic actions ; royal jelly ; anti-inflammatory activity ; antioxidant activity ; natural products ; anticancer potential ; biological activity ; systemic lupus erythematosus ; clinical ; autoimmune diseases ; natural product ; supplement ; medicinal plant ; immunomodulatory ; review ; herbal medicine ; psoriasis ; Ficus carica fruit extract ; JAK–STAT modulation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Research in ophthalmic drug delivery has developed significant advances in the last few years, and efforts have been made to develop more effective topical formulations to increase drug bioavailability, efficiency, and safety. Drug delivery to the posterior segment of the eye remains a great challenge in the pharmaceutical industry due to the complexity and particularity of the eye's anatomy and physiology. Some advances have been made with the purpose of maintaining constant drug levels in the site of action. The anatomical ocular barriers have a great impact on drug pharmacokinetics and, subsequently, on the pharmacological effect.Despite the increasing interest in efficiently reaching the posterior segment of the eye with reduced adverse effects, there is still a need to expand the knowledge of ocular pharmacokinetics that allow the development of safer and more innovative drug delivery systems. These novel approaches may greatly improve the lives of patients with ocular pathologies.
    Keywords: excitotoxicity ; neurodegeneration ; retina ; microparticles ; controlled drug release ; rebamipide ; sustained delivery system ; dry eye ; eyelid ; mucin ; ocular pharmacokinetics ; ocular drug delivery systems ; ocular routes of drug administration ; intravitreal administration ; topical administration ; anti-angiogenesis ; corneal neovascularization (NV) ; epigallocatechin gallate (EGCG) ; gelatin ; hyaluronic acid (HA), nanoparticles ; RGD peptide ; eye drops ; retinal penetration ; neuroprotection ; protein aggregation ; stability ; intravitreal delivery ; CNTF ; corticosteroids ; drug delivery systems ; intravitreal dexamethasone implant ; intravitreal injections ; Ozurdex ; drug delivery ; glaucoma ; ROCK inhibitor ; fasudil ; PLGA microspheres ; intravitreal injection ; trabecular meshwork ; Schlemm’s canal ; retinal pigment epithelium ; Electric Cell-Substrate Impedance Sensing ; dexamethasone acetate ; cyclodextrins ; hydrogels ; rheology ; cytotoxicity studies ; transcorneal permeation ; radiolabeled ocular biopermanence ; blood-retinal barrier ; cationic drug ; transport ; lysosomal trapping ; atropine ; ophthalmic solution ; myopia ; amphotericin B ; γ-cyclodextrins ; fungal keratitis ; lutein ; PLGA ; PLGA–PEG–biotin ; ARPE-19 ; macular edema ; age-related macular degeneration ; biotin-decorated nanoparticles ; polymeric nanoparticles ; targeted therapy ; ocular drug delivery ; half-life extension ; albumin ; therapeutic proteins ; size exclusion chromatography ; iron ; retinal degeneration ; retinitis pigmentosa ; transferrin ; gene therapy ; plasmid electrotransfection ; dexamethasone ; poly(lactic-co-glycolic) acid ; ophthalmology ; microspheres ; periocular administration ; gamma sterilization ; tolerance ; in vitro model ; in vitro drug release ; intravitreal implants ; SLA 3D-printing ; triamcinolone acetonide ; USP apparatus 4 ; USP apparatus 7 ; vitreous substitute ; dissolution ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Plastic and reconstructive surgery has a broad spectrum of different reconstructive techniques, including split skin transplantation and local and free flaps. By means of microsurgery and perforator flaps, every reconstructive issue can be addressed by tailored techniques. Flaps can comprise different tissues and can be designed using new imaging technologies in order to increase the safety of the procedures and to retain the form and function of the reconstructed area in accordance with the donor site morbidity. This Special Issue of the Journal of Personalized Medicine focuses on the following topics:Individualized microsurgery;Flap imaging;Customized perforator flaps;Monitoring flap perfusion;Tailored tissue engineering for reconstruction;Biofabrication applications in personalized plastic and reconstructive surgery.
    Keywords: flap grafting ; microsurgery ; biosensor ; bioelectrical impedance ; rat ; hyperspectral imaging ; Allen’s test ; radial forearm free flap ; microvascular surgery ; reconstructive surgery ; perfusion monitoring ; flap imaging ; critical bone defect ; vascularized fibula ; Capanna technique ; Masquelet induced membrane ; intercalary reconstruction ; bone tumor ; ballistic trauma ; perforator flaps ; DIEP ; thermal imaging ; laser Doppler ; perineal reconstruction ; VRAM flap ; neourethra ; urethral reconstruction ; posttraumatic lymphedema ; long bone fractures ; soft tissue injury ; lower extremity ; HSI ; objective ; hyperspectral signature ; timely recognition ; reconstruction ; head and neck ; non-invasive ; non-contact ; cytostatic agents ; doxorubicin ; indocyanine green ; oncology ; perfusion ; surgical oncology ; peripheral nerve injury ; psychosocial factor ; nerve repair ; neuroma ; brachial plexus injury ; compression neuropathy ; pain ; depression ; disability ; quality of life ; scar ; scar therapy ; algorithm ; free flap ; tissue transfer ; perforator propeller flap ; combined perforator propeller flap ; soft tissue reconstruction ; propeller flap ; perforator flap ; irradiation ; imaging ; malperfusion ; sternal defect reconstruction ; deep sternal wound infection ; DSWI ; reconstructive microsurgery ; tensor fasciae latae flap ; TFL flap ; muscle transplantation ; rat gastrocnemius ; in situ stimulation ; muscle contraction ; perfusion-decellularization ; autologous breast reconstruction ; free tissue transfer ; indocyanine green angiography ; transit-time flowmetry ; neurofibromatosis ; craniofacial ; surgical treatment ; multidisciplinary team ; plexiform neurofibroma ; forequarter amputation ; targeted muscle reinnervation ; osteomusculocutaneous flap ; fillet flap ; epaulette flap ; interscapulothoracic amputation ; spare parts ; CTA ; DIEP flap ; MS-TRAM flap ; perforator ; personalized medicine ; reconstructive breast surgery ; mastectomy-skin-flap perfusion ; mastectomy-skin-flap necrosis ; suture materials ; crush load ; mechanical properties ; wound closure ; adipose-derived stem cells ; ADSC ; MCF-10A ; mammary epithelial cells ; fibroblasts ; epithelial-mesenchymal transition ; mesenchymal markers ; breast infection ; peri-prosthetic infection ; breast implant infection ; silicone prostheses ; negative pressure wound therapy ; instillation ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MN Surgery
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint focused on the advancements in the field of shoulder arthroplasty in recent years. These concern surgical indications that have dramatically evolved and planification and navigation. The rapid development of surgical techniques and new prosthetic designs, as well as glenoid and humeral reconstruction for various conditions, is also overviewed. Despite the important progress highlighted in this reprint, there is currently a myriad of prosthetic designs, highlighting the evolving nature of this field.
    Keywords: reverse total shoulder arthroplasty ; DSA ; LSA ; lateralization ; distalization ; radiographic analysis ; shoulder arthroplasty ; glenohumeral osteoarthritis ; avascular necrosis of the humeral head ; hemi arthroplasty ; total shoulder arthroplasty ; young patients ; prosthesis ; design ; range of motion ; degeneration ; PROMs ; results ; complication ; reverse shoulder arthroplasty ; proximal humerus fracture ; hemiarthroplasty ; projections ; revision ; shoulder ; arthroplasty ; anatomic arthroplasty ; reverse arthroplasty ; periprosthetic shoulder infection ; two-stage exchange ; mortality ; reimplantation ; defect ; reconstruction ; autologous graft ; survivorship ; loosening ; integration ; patient reported outcome measures ; VBHC ; value-based health care ; patient value ; quality ; costs ; COVID ; coronavirus ; length of stay ; same-day discharge ; pandemic ; tranexamic acid ; TXA ; arthroscopy ; bleeding ; systematic review ; meta-analysis ; acromion morphology ; glenoid retroversion ; wear ; osteoarthritis ; computed tomography ; anatomic total shoulder replacement ; reverse total shoulder replacement ; Lazarus score ; Sirveaux score ; older patients ; clinical scores ; conversion ; failed hemiarthroplasty ; shoulder hemiprosthesis ; modular reverse prosthesis ; glenohumeral osteoarthrosis ; shoulder dislocation ; shoulder instability ; dislocation arthropathy ; stemless ; inlay ; onlay ; augment ; head split ; splitting ; tuberosity ; healing ; union ; trauma ; humerus ; low ; high ; energy ; double shadow ; pelican sign ; anatomical total shoulder arthroplasty ; posteroinferior approach ; rotator cuff-sparing ; anatomical study ; cuff tear arthropathy ; polyethylene ; scapular notching ; larger glenosphere ; clinical outcome ; metal back glenoid ; midterm results ; radiologic outcome ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Berghahn Books
    Publication Date: 2024-04-02
    Description: Over the course of its history, the German Empire increasingly withheld basic rights-such as joining the army, holding public office, and even voting-as a form of legal punishment. Dishonored offenders were often stigmatized in both formal and informal ways, as their convictions shaped how they were treated in prisons, their position in the labour market, and their access to rehabilitative resources. With a focus on Imperial Germany's criminal policies and their afterlives in the Weimar era, Citizens into Dishonored Felons demonstrates how criminal punishment was never solely a disciplinary measure, but that it reflected a national moral compass that authorities used to dictate the rights to citizenship, honour and trust.
    Keywords: History ; European Studies ; Political Science ; Peace & Conflict Studies ; Law ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPV Political control and freedoms::JPVH Human rights, civil rights ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAZ Legal history
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    Edinburgh University Press | Edinburgh University Press
    Publication Date: 2024-04-02
    Description: Bringing together specialists in ancient history, archaeology and Roman law, this book provides new perspectives on long-distance trade in the Roman world. Recent archaeological work has shown that maritime trade across the Mediterranean intensified greatly at the same time as the Roman state was extending its power overseas. This book explores aspects of this development and its relationship with changes in the legal and institutional apparatus that supported maritime commerce. It analyses the socio-legal framework within which maritime trade was conducted, and in doing so presents a new understanding of the role played by legal and social institutions in the economy of the Roman world.
    Keywords: History ; Ancient ; Rome ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: The Special Issue entitled “Pediatric and adolescent nephrology facing the future: diagnostic advances and prognostic biomarkers in everyday practice” contains articles written in the era when COVID-19 had not yet been a major clinical problem in children. Now that we know its multifaceted clinical course, complications concerning the kidneys, and childhood-specific post-COVID pediatric inflammatory multisystem syndrome (PIMS), the value of diagnostic and prognostic biomarkers in the pediatric area should be appreciated, and their importance ought to increase.
    Keywords: chronic kidney disease ; cytokines ; solitary functioning kidney ; tumor necrosis factor-like weak inducer of apoptosis ; netrin-1 ; renal tubular damage ; premature newborns ; overactive bladder ; urinary microbiome ; children ; adolescents ; cystatin C ; galectin-3 ; periostin ; primary hypertension ; arterial damage ; blood pressure ; neurogenic bladder ; myelomeningocele ; markers ; furosemide stress test ; hyperfiltration ; [IGFBP-7] × [TIMP-2] ; NGAL ; renal angina index ; renal functional reserve ; tubular damage ; tubuloglomerular feedback ; neurotrophins ; transcutaneous electrical nerve stimulation ; hemopexin ; nephrotic syndrome ; HNF1B ; hyperuricemia ; PTH ; renal function ; uric acid ; FEUA ; sclerostin ; obesity ; childhood ; dental caries ; gingivitis ; kidney injury ; glomerulopathy ; glomerular injury ; alpha-1 acid glycoprotein ; urinary mRNA expression of podocyte-associated proteins ; cathepsin B ; premature neonates ; immaturity ; NT-proBNP ; cardiovascular disease ; common carotid artery intima-media thickness ; bone morphogenetic protein (BMP)-2 ; bone morphogenetic protein (BMP)-6 ; extracellular matrix metalloproteinases inducer (EMMPRIN) ; macrophage migration inhibitory factor (MIF) ; tubular functional reserve ; cytokeratin-18 ; endoglin ; transforming growth factor-β1 ; renal fibrosis ; congenital obstructive nephropathy ; diabetic kidney disease ; vascular endothelial markers ; eGFR ; adenine nucleotide metabolites ; chronic renal failure ; antibiotic resistance ; Escherichia coli ; inflammatory markers ; urinary tract infection ; B2M ; cancer ; CCS ; CKD ; nephropathies ; renal toxicity ; voiding cystography ; infection ; urinary tract ; IgA nephropathy ; IgA vasculitis with nephritis ; vanin-1 ; biomarker ; urinary tract infections ; artificial intelligence ; machine learning ; medical decision support system ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Hepatic encephalopathy (HE) is a complex neurological syndrome, characteristic of patients with liver disease, that causes a wide and complex spectrum of nonspecific neurological and psychiatric manifestations, ranging from a subclinical entity such as minimal or covert hepatic encephalopathy to a deep form in which a complete alteration of consciousness can be observed: overt hepatic encephalopathy. Both minimal and overt hepatic encephalopathy have a high impact on patients, caregivers, and national health services, driving substantial consumption of economic resources. In this Special Issue, we discussed the current state-of-the-art research, address ongoing knowledge gaps, and ongoing controversies related to the pathogenesis, diagnosis, and therapeutic management of hepatic encephalopathy.
    Keywords: hyperammonemia ; liver ; mitochondria ; ketogenesis ; gluconeogenesis ; brain energy crisis ; cirrhosis ; liver disease ; epidemiology ; hepatic encephalopathy ; transjugular portosystemic intrahepatic shunt ; liver cirrhosis ; minimal hepatic encephalopathy ; nerve conduction ; thermal sensitivity ; autonomic testing ; n/a ; bile acids ; antibiotic resistance ; enema ; capsules ; hospitalizations ; cognitive function ; liver failure ; encephalopathy ; delirium ; coma ; porto-sinusoidal vascular liver disease ; idiopathic non-cirrhotic portal hypertension ; portal vein thrombosis ; porto-systemic shunt ; sarcopenia ; myosteatosis ; protein caloric-malnutrition ; dietary intervention ; mortality ; quality of life ; sleep disorders ; therapy ; non-absorbable disaccharides ; rifaximin ; bic Book Industry Communication::M Medicine
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    UGA Éditions
    Publication Date: 2024-04-02
    Description: Par le biais de l’examen d’une pluralité de sources, cet ouvrage analyse l’évolution du regard que les voyageurs français portèrent sur l’architecture et sur le paysage vénitien, entre 1756 et 1850. Lentement façonnée par les siècles, la Sérénissime est le produit de l’histoire et le miroir le plus éloquent du passage du temps comme le prouve le curieux dialogue qui s’est peu à peu instauré entre la nature et les vieilles pierres de ses édifices. Comment les voyageurs ont-ils perçu, d’un siècle à l’autre, l’étroite connivence qui se manifeste à Venise entre la nature sauvage et le bâti harmonieux ? Tout en se démarquant de la domination qu’exercent les études littéraires dans le domaine du voyage à Venise, cette étude reconstitue donc les transformations du regard sur l’architecture et analyse le processus de « réévaluation » progressive de l’eau lagunaire, du voyage naturaliste de la fin du XVIIIe siècle, à l’apparition d’un tourisme balnéaire dans la Venise des Habsbourg.
    Keywords: voyageurs français ; nature ; paysage ; architecture ; thermalisme ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    Cornell University Press | Cornell University Press
    Publication Date: 2024-04-02
    Description: In The Cold War from the Margins, Theodora K. Dragostinova reappraises the global 1970s from the perspective of a small socialist state—Bulgaria—and its cultural engagements with the Balkans, the West, and the Third World. During this anxious decade, Bulgaria's communist leadership invested heavily in cultural diplomacy to bolster its legitimacy at home and promote its agendas abroad. Bulgarians traveled the world to open museum exhibitions, show films, perform music, and showcase the cultural heritage and future aspirations of their "ancient yet modern" country. As Dragostinova shows, these encounters transcended the Cold War's bloc mentality: Bulgaria's relations with Greece and Austria warmed, émigrés once considered enemies were embraced, and new cultural ties were forged with India, Mexico, and Nigeria. Pursuing contact with the West and solidarity with the Global South boosted Bulgaria's authoritarian regime by securing new allies and unifying its population. Complicating familiar narratives of both the 1970s and late socialism, The Cold War from the Margins places the history of socialism in an international context and recovers alternative models of global interconnectivity along East-South lines. Thanks to generous funding from The Ohio State University Libraries and its participation in TOME (Toward an Open Monograph Ecosystem), the ebook editions of this book are available as Open Access volumes from Cornell Open (cornellpress.cornell.edu/cornell-open) and other repositories.
    Keywords: Cultural diplomacy, global cold war, socialist bulgaria, communist bulgaria, globalization ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSD Diplomacy
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint is an excellent collection of articles that deal with difficult-to-treat infections in the ICU environment. Multiresistant bacteria and fungi create severe treatment problems to the physician charged with their care. We hope that this book will help everyday dilemmas and add useful information on difficult topics.
    Keywords: Acinetobacter ; pandrug-resistant ; antimicrobial combinations ; synergy ; renal replacement therapy ; Monte Carlo simulation ; antibiotics ; pharmacokinetics ; pharmacodynamics ; microbiome ; probiotics ; intensive care unit ; dysbiosis ; ventilator-associated pneumonia ; extracorporeal membrane oxygenation ; ECMO ; critical illness ; antibiotic choices ; HAP ; VAP ; colonization ; antibiotic pressure ; bloodstream infection ; bacteraemia ; sepsis ; septic shock ; empirical ; probabilistic antibiotics ; source control ; de-escalation ; ICU ; intensive care ; antimicrobial stewardship ; COVID-19 ; procalcitonin ; C-reactive protein ; presepsin ; infection ; biomarker ; guided antimicrobial therapy ; APACHE II score ; bacteremia ; broth microdilution ; colistin ; colistin-resistant ; Gram-negative ; mortality ; SOFA score ; candidemia ; incidence ; epidemiology ; Candida species ; non-albicans Candida species ; fluconazole resistance ; critically ill ; beta-lactam antibiotics ; Acinetobacter baumannii ; antibiotic optimisation ; antibiotic stewardship (AMS) ; aspiration pneumonia ; hospital-acquired pneumonia (HAP) ; multidrug-resistance (MDR) ; non-fermentative Gram-negative bacilli (GNB) ; polymicrobial ; pneumonia resolution ; ventilator-associated pneumonia (VAP) ; carbapenem-resistant A. baumannii (CRAb) ; infection control ; antimicrobial agents ; carbapenems ; antibiotic resistance ; clinical pharmacy services ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; salvage treatment ; double carbapenem ; newer β-lactam-β-lactamase inhibitors ; cefiderocol ; eravacycline ; SARS-CoV-2 infection ; mechanical ventilation ; risk factors ; blood stream infection ; defined daily dose ; antibiotics utilization ; empiric ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: This reprint offers a comprehensive and updated overview of the current state-of-the-art techniques in the management of various neurological disorders. These disorders include neurodegenerative diseases, neurovascular disorders, and neuro-oncological diseases. The reprint also presents the latest advances and innovations in the diagnosis, treatment, and prevention of these complex conditions, emphasizing the role of cutting-edge technologies, such as neurobiology, neuroimaging, neuroinformatics, neuropharmacology, and neurosurgery. This reprint is a useful resource for researchers, clinicians, students, and anyone interested in the current challenges and perspectives of neurological disorders.
    Keywords: atherosclerotic ; residual stenosis ; reocclusion ; endovascular treatment ; Alzheimer’s disease ; mild cognitive impairment ; tau positron emission tomography ; deep learning radiomics ; glioblastoma ; natural killer cells ; immune function ; interferon ; gross total resection ; neuropsychological tests battery ; machine learning ; screening tool ; Florzolotau PET ; functional connectivity ; neuronal intranuclear inclusion disease ; NIID ; mitochondrial dysfunction ; MELAS ; reversible DWI hyperintensities ; virtual reality ; neurological ; cognitive ; rehabilitation ; diagnosis ; metaverse ; Erdheim–Chester disease ; histiocytosis ; neurohistiocytosis ; cerebellar ataxia ; myelin proteolipid protein ; protein structure prediction ; functional analysis ; multiple sclerosis ; amyotrophic lateral sclerosis ; NOTCH2NLC ; intermediate-length repeats ; nucleotide repeat expansion ; Tau PET ; radiomics ; Alzheimer’s Disease ; Mild Cognitive Impairment ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: This reprint focuses on fundamental and applied research on asymmetry of movement and postural balance and underlying functions in humans. Experimental protocols based on kinetic, kinematic, radiological, functional magnetic resonance imaging and transcranial Doppler ultrasound data taken from healthy, young, elderly and pathological individuals provide new insights into asymmetry in human movement and posture and are presented in the Special Issue.
    Keywords: gait ; kinematics ; spatio-temporal ; multiple sclerosis (MS) ; cyclograms ; angle-angle diagrams ; symmetry ; self-face recognition ; right hemisphere ; self-awareness ; asymmetry ; human ; development ; locomotion ; posture ; walking robot ; dominant leg ; acute exercise ; fatigue ; sport practice ; middle cerebral artery ; diameter ; blood flow ; stroke ; shear stress ; neonate ; handedness ; sidedness ; brain asymmetry ; children posture ; side dominance ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Arc Humanities Press
    Publication Date: 2024-04-07
    Description: The problem of fraternal relations in the early Middle Ages has not been hitherto studied in detail, especially in comparison with the multitude of studies dealing with the models of marriage, gender-based social roles, or the relations between generations. Historians have been often prone to assume that relations between siblings in European culture were naturally constant, based on loyalty, solidarity, and readiness to act in the common interest, stemming from blood ties. However, this conviction equates the category of brotherhood/fraternitas used by medieval authors with concepts associated with sources from later periods. This study does not concern narrowly defined family history, but is an attempt to examine fraternal relations in the early Middle Ages as a multidimensional cultural phenomenon. As the author seeks to demonstrate, it is difficult to speak of kinship in the ninth century and later without being aware of the religious and ideological implications of the transformations taking place at the time, even if direct traces of the impact of moralizing and theological teachings on the conduct of individuals are hard to capture in the sources.
    Keywords: early Middle Ages;kinship;brotherhood;brothers ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English
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    Bloomsbury Academic | Bloomsbury Publishing (UK)
    Publication Date: 2024-04-02
    Description: This open access book brings together an eclectic cast of scholars in related disciplines to examine ageing in the Soviet Union, covering the practice of geriatrics, the science of gerontology, and the experience of growing old. Chapters in the book focus on concepts and themes that analyse Soviet ageing in its medical, political and social contexts, both in the Soviet Union and internationally. Ageing was hardly a uniquely Soviet phenomenon: over the past fifty years, moreover, governments and societies have been dealing with steady increases in their ageing populations. Almost paradoxically, however, societal focus on this ageing population, its lives, and its social impact remains extremely limited. Compared to most sciences, gerontology is pitifully underfunded; geriatrics is amongst the least prestigious branches of medicine; and while the world’s population is growing undeniably older, great disagreement remains over what can and should be done in response. These were the same challenges that the USSR faced in the post-war decades (1945-1991), and the contributions included in this volume help to flesh out and contextualize the example of Soviet gerontology and geriatrics as one possible model of response. Geriatrics and Ageing in the Soviet Union captures the growing interest in this important subject, demonstrating the influence of ageing on Soviet science and society and the impact of Soviet gerontology and geriatrics at a global level. The book is available under a CC BY-NC-ND 3.0 licence on bloomsburycollections.com. Open access was funded by the Wellcome Trust and Liverpool John Moores University.
    Keywords: ageing ; geriatrics ; Soviet Union ; Russia ; modern history ; history ; society ; culture ; social history ; cultural history ; medicine ; history of medicine ; politics ; political history ; domestic issues ; domesticity ; internationality ; science ; gerontology ; global history ; internationalism ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-02
    Description: In 2020, a group of European researchers got a European Union (EU) grant to do a project called TRANSFORM. The objective of TRANSFORM was to integrate the principle of responsible research and innovation (RRI) into the research and innovation policies of three European regions: Lombardy, Brussels, and Catalonia. This book tells the story of how TRANSFORM translated RRI into practice, all the way from philosophy of technology to EU policy jargon, to the project contract, and finally into the real-life events in these regions. Responsibility was translated in creative ways, with surprising goals and ambiguous outcomes. Armed with these stories, the book analyses the broader context of the desire for better governance of technoscience and draws two lessons: Firstly, that there is more governance than one may see at first sight, and secondly, that there is a need to rethink the borders of technoscience and the spaces in which it resides. The book proposes to think of governance in technoscience, rather than governance of technoscience.
    Keywords: Responsible Research and Innovation;technoscience ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history
    Language: English
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    De Gruyter | De Gruyter
    Publication Date: 2024-03-27
    Description: Italian literature emerged around 1600 at the intersection of poetological and religious attempts at standardization and under the attentive watch of a literary community and its critical discussions as well as the censorship and inquisition of the Counter-Reformation. This volume sheds light on creativity under the conditions of this twofold "observance" by looking at texts from various genres written between ca. 1550 and 1650.
    Keywords: Censorship ; Aristotelianism ; Counter-Reformation ; opera libretto ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTZ General studies and General knowledge ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: German , English
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-07
    Description: The monograph realigns political culture and countermeasures against slave raids, which rose during the breakup of the Golden Horde. By physical defense of the open steppe border and embracing the New Israel symbolism (exodus from slavery in Egypt/among the Tatars), Muscovites found a defensive model to expand the empire. Recent debates on slaving are introduced to Russian and imperial history, while challenging entrenched perceptions of Muscovy.
    Keywords: Muscovite slavery ; Russian history ; imperial history ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Casa de Velázquez
    Publication Date: 2024-04-02
    Description: Durant la minorité de Charles II, des polémiques opposent Juan José de Austria, fils naturel de Philippe IV, aux favoris successifs de la reine-mère qui exerce la régence. Au terme de guerres de plumes, ce prince obtient l’exil des favoris et devient Premier ministre. Sa trajectoire originale met en évidence des pratiques politiques qui, en misant sur la force de l’écrit, permettent de résister aux autorités — sans désobéir ouvertement — et de gravir les marches du pouvoir. Ainsi ces guerres de plumes ont-elles bouleversé les cultures politiques, modifié les pratiques de gouvernement et contribué, peut-être, à l’avènement d’une opinion publique.
    Keywords: opinion ; libelle ; pamphléte ; valido ; Valenzuela ; Consuegra ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: Dual disorders, meaning the coexistence in the same individual of a substance use disorder and another mental disorder, have become an area of great interest in the fields of psychiatry and addiction and in health overall due to their high prevalence, clinical relevance and multicultural presence. This book includes a compilation of papers published between the end of 2021 and the beginning of 2023 focused on recent advances in dual disorders. The contributions present a broad look at various relevant aspects. Among them are the characterization of patients treated in different services, with special interest in the risk of overdoses, suicidal attempts and HIV, as well as the so-forgotten gender perspective and the impact of the COVID-19 pandemic on the attention of addiction centers. One of the first studies to consider the comorbidity of gambling disorders with substance use is also presented. The possible usefulness of explanatory models of machine learning for diagnosis and for performing chronobiological measurements that allow a more individualized treatment stand out among the novel contributions to the field of dual disorders. The aim of each of the contributions of this reprint is to be transferred for the benefit of clinical practice.
    Keywords: circadian rhythm ; dual disorders ; chronobiology ; substance use disorders ; schizophrenia ; major depressive disorder ; bipolar disorder ; distal skin temperature ; dual diagnosis ; consultation liaison service ; quality of life ; gender ; substance use disorder ; genetic polymorphisms ; neurocognition ; chronobiological therapy ; exposure to natural light ; clinical course ; alcohol-use disorders ; personality disorders ; externalizing ; network analysis ; antisocial personality disorder ; borderline personality disorder ; dual disorder ; mental disorders ; screening ; cocaine use disorder ; alcohol use disorder ; substance-related disorders ; treatment retention ; cannabis use disorder ; machine learning ; dual pathology ; COVID-19 ; care activity ; pandemic ; drug addiction ; mental health ; gambling disorder ; gambling-related offenses ; dropout ; relapse ; psychopathology ; personality ; substance use ; psychiatric comorbidity ; impulsivity ; co-occurring disorders ; suicidality ; overdose ; HIV ; patient navigation ; barriers to care ; social determinants of health ; syndemic framework ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Berghahn Books
    Publication Date: 2024-04-02
    Description: Presenting a new historical narrative on European integration and identity this title examines how the concept of Europe has been entangled in a dynamic and dramatic tension between calls for unity and arguments for borders and division. Through an in-depth intellectual history of the idea of Europe, Mats Andren interrogates the concept of integration and more recent debates surrounding European identity across the nineteenth and early twentieth centuries and the post-war period. Applying a broad range of original sources this unique work will be key reading for students and researchers studying European History, European Studies, Political History and related fields.
    Keywords: History ; European Studies ; Political Science ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::N History and Archaeology::NH History::NHA History: theory and methods::NHAH Historiography
    Language: English
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    Cornell University Press | Cornell University Press
    Publication Date: 2024-04-02
    Description: In The World Refugees Made, Pamela Ballinger explores Italy's remaking in light of the loss of a wide range of territorial possessions—colonies, protectorates, and provinces—in Africa and the Balkans, the repatriation of Italian nationals from those territories, and the integration of these "national refugees" into a country devastated by war and overwhelmed by foreign displaced persons from Eastern Europe. Post-World War II Italy served as an important laboratory, in which categories differentiating foreign refugees (who had crossed national boundaries) from national refugees (those who presumably did not) were debated, refined, and consolidated. Such distinctions resonated far beyond that particular historical moment, informing legal frameworks that remain in place today. Offering an alternative genealogy of the postwar international refugee regime, Ballinger focuses on the consequences of one of its key omissions: the ineligibility from international refugee status of those migrants who became classified as national refugees. The presence of displaced persons also posed the complex question of who belonged, culturally and legally, in an Italy that was territorially and politically reconfigured by decolonization. The process of demarcating types of refugees thus represented a critical moment for Italy, one that endorsed an ethnic conception of identity that citizenship laws made explicit. Such an understanding of identity remains salient, as Italians still invoke language and race as bases of belonging in the face of mass immigration and ongoing refugee emergencies. Ballinger's analysis of the postwar international refugee regime and Italian decolonization illuminates the study of human rights history, humanitarianism, postwar reconstruction, fascism and its aftermaths, and modern Italian history.
    Keywords: refugees, repatriation, citizenship, decolonialization, Italy, national assistance, humanitarian response to displacement ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFG Refugees and political asylum ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPV Political control and freedoms::JPVH Human rights, civil rights
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    Casa de Velázquez
    Publication Date: 2024-04-02
    Description: L’histoire contemporaine de l’Espagne n’est pas toute orientée vers le drame de la Guerre civile et du franquisme, pas plus que vers la quête de leurs origines. Sortir de ce « labyrinthe » signifie replacer, dans la durée, l’Espagne dans une histoire de l’Europe et des espaces coloniaux pour faire émerger d’autres logiques moins déterministes. Peu à peu, depuis deux décennies, ce renouvellement s’est imposé, et Gérard Chastagnaret en a été l’un des acteurs importants. Les textes réunis dans ce livre explorent des thèmes que G. Chastagnaret a directement abordés ou qu’il a su encourager : l’histoire des mines, des entreprises, des innovations, l’histoire de l’État et des élites de la fin du xviiie siècle au milieu du xxe siècle. Ce volume n’est pas bilan complaisant, il veut être un témoignage de la fécondité des échanges entre historiens français et espagnols, hier et aujourd’hui.
    Keywords: colonialisme ; industrialisation ; histoire économique ; Philippines ; Cadix ; minérie ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    Casa de Velázquez
    Publication Date: 2024-04-02
    Description: This book reconstructs Perpignan's economic activities and the merchant networks, particularly foreign ones, that deployed them across the Mediterranean between the end of the 13th century and the end of the 15th century. Thanks to a wealth of handwritten correspondence, it also traces the career and profile of the city's leading businessman at the turn of the 15th century, the origin of an influential lineage. It thus reconstructs a little-known part of the city's history.
    Keywords: Perpignan ; trade ; Mediterranean ; ego-document ; Roussillon ; Consulate of the Sea ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: French
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    Bloomsbury Academic | Bloomsbury Academic
    Publication Date: 2024-04-02
    Description: Interwar European minority questions have been predominantly discussed in the context of Eastern Europe until now. This open access book challenges that geographical emphasis by examining both Eastern and Western European experiences. It thus lays the foundation for a new comparative international history of the relations between national majorities and minorities in Europe after the Great War. Building on the assumption that nationalist conflicts are based on dynamic interactions between multiple actors, this book brings together different perspectives and methodological approaches (political, social and transnational) to provide a comprehensive account of minority questions between the two World Wars. With contributions from leading academics and emerging scholars based in Austria, Ireland, Poland, Spain, Switzerland, the UK and the USA among others, Sovereignty, Nationalism, and the Quest for Homogeneity in Interwar Europe is a wide-ranging study which is firmly anchored in the history of the transition from empires to nation-states as well as in the history of human rights and the nation-state. The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 licence on bloomsburycollections.com. Open access was funded by the Swiss National Science Foundation (SNSF).
    Keywords: European history ; General and world history ; Political science and theory ; Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: The present Special Issue will lead you to discover the association between cardiovascular and metabolic diseases, through update reviews and original articles exploring the pathophysiological mechanisms underpinning this association and describing the latest results in term of cardiovascular event prevention. An interesting scientific journey that reflects the recent advances in pharmacological treatments and interventional procedures.
    Keywords: low-density lipoprotein receptor ; apolipoprotein E ; hyperglycemia ; type 2 diabetes ; Western diet ; diabetes mellitus ; GPCRs ; GPR26 ; monocytes ; peripheral blood cells ; metabolomics ; diabetes ; N-Acetyl asparagine ; QTc ; cardiac fibrosis ; scar tissue ; anti-fibrotic therapies ; cardiovascular diseases ; myofibroblasts ; nitric oxide synthase uncoupling ; sapropterin ; diabetic nephropathy ; atrial fibrillation ; hyperthyroidism ; warfarin ; ischemic stroke ; transient ischemic attack ; transplant ; complications ; mortality ; outcome ; glucose metabolism ; body mass index ; metabolic syndrome ; breast arterial calcifications ; cardiovascular risk ; mammograms ; risk assessment ; prevention ; cost effectiveness ; cardiac autonomic neuropathy ; oxidative stress ; inflammation ; endothelium dysfunction ; direct oral anticoagulant ; stroke prevention ; elderly ; frail ; malignancy ; extreme weight ; bioprosthetic valve ; endocannabinoid system ; CB1 cannabinoid receptor ; metabolic disease ; non-alcoholic fatty liver disease ; sodium-glucose cotransporter inhibitors ; metformin ; FibroScan® ; controlled attenuation parameter ; type 2 diabetes mellitus ; heart failure ; hemodynamics ; dapagliflosin ; adropin ; natriuretic peptide ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Cornell University Press | ILR Press
    Publication Date: 2024-04-03
    Description: Crafting the Movement presents an explanation of why the Swedish working class so unanimously adopted reformism during the interwar period. Jenny Jansson discusses the precarious time for the labor movement after the Russian Revolution in 1917 that sparked a trend towards radicalization among labor organizations and communist organizations throughout Europe and caused an identity crisis in class organizations. She reveals that the leadership of the Trade Union Confederation (LO) was well aware of the identity problems that the left-wing factions had created for the reformist unions. Crafting the Movement explains how this led labor movement leaders towards a re-formulation of the notion of the worker by constructing an organizational identity that downplayed class struggle and embraced discipline, peaceful solutions to labor market problems, and cooperation with the employers. As Jansson shows, study activities arranged by the Workers' Educational Association became the main tool of the Trade Union Confederation's identity policy in the 1920s and 1930s and its successful outcome paved the way for the well-known "Swedish Model." Thanks to generous funding from Uppsala University, the ebook editions of this book are available as Open Access volumes from Cornell Open (cornellpress.cornell.edu/cornell-open) and other Open Access repositories.
    Keywords: Sweden, Class formation, Labor leaders, Trade union movement, Identity entrepreneurs ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNX Industrial relations, occupational health and safety::KNXN Industrial arbitration and negotiation ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJH Entrepreneurship / Start-ups ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Open Book Publishers
    Publication Date: 2024-04-02
    Description: The European Experience brings together the expertise of nearly a hundred historians from eight European universities to internationalise and diversify the study of modern European history, exploring a grand sweep of time from 1500 to 2000. Offering a valuable corrective to the Anglocentric narratives of previous English-language textbooks, scholars from all over Europe have pooled their knowledge on comparative themes such as identities, cultural encounters, power and citizenship, and economic development to reflect the complexity and heterogeneous nature of the European experience. Rather than another grand narrative, the international author teams offer a multifaceted and rich perspective on the history of the continent of the past 500 years. Each major theme is dissected through three chronological sub-chapters, revealing how major social, political and historical trends manifested themselves in different European settings during the early modern (1500–1800), modern (1800–1900) and contemporary period (1900–2000). This resource is of utmost relevance to today’s history students in the light of ongoing internationalisation strategies for higher education curricula, as it delivers one of the first multi-perspective and truly ‘European’ analyses of the continent’s past. Beyond the provision of historical content, this textbook equips students with the intellectual tools to interrogate prevailing accounts of European history, and enables them to seek out additional perspectives in a bid to further enrich the discipline.
    Keywords: modern European history;European prospective;identities;cultural encounters;power;citizenship;economic development ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: It is well known that pregnancy complications, including preeclampsia, preterm birth, stillbirth, and intrauterine growth restriction affect over 12% of all pregnancies worldwide. These complications negatively impact both maternal and neonatal health and have short- and long-term effects such as an increased risk of neurodevelopmental and cardiovascular diseases. Over the past decade, numerous groups have investigated the use of new and/or existing drugs to either prolong gestation, such as in cases of threatened preterm labour; alleviate hypertension in preeclampsia; or promote adequate blood flow and nutrient delivery to the placenta to facilitate growth in IUGR. The overarching goal has been to promote healthier pregnancies and neonatal health, but it has been difficult to translate this work into the clinical setting, with problems in terms of drug delivery, specificity, and importantly, the early diagnostic capacities for complications in pregnancy. This book focuses on the early detection, potential novel therapeutic targets, risk factors, maternal outcomes, and long-term consequences of this critical problem.
    Keywords: ultrasonography ; elastography ; uterine cervix ; term pregnancy ; parturition ; genotyping ; preeclampsia ; MMP-9 ; MMP-2 ; SNPs ; tocolytic ; preterm birth ; preterm labor ; neonate ; prematurity ; pregnancy ; therapeutic ; progesterone ; fetus ; sex as a biological variable ; sex differences ; pregnancy complications ; placenta ; prenatal diagnosis ; fetal growth restriction ; miscarriage ; chorio-deciduitis ; grade ; amnionitis ; acute histologic chorioamnionitis ; intra-amniotic inflammatory response ; beta-blocker ; endothelial dysfunction ; cardiovascular disease ; pregnancy loss ; immunology ; vascular endothelial growth factor ; galectin-9 ; interleukin-4 ; proteomics ; urine ; biomarkers ; IBP4 ; SHBG ; RPL ; NK cells ; sildenafil ; PDE5A ; VEGF-A ; angiotensin ; infant ; newborn ; female ; abruptio placentae ; Apgar score ; pregnant women ; gestational age ; IL-1 blockade ; anakinra ; canakinumab ; human ; inflammation ; fetal growth restriction (FGR) ; intra-uterine growth restriction (IUGR) ; SPINT1 ; HAI-1 ; stillbirth ; placental insufficiency ; histopathology ; cardiovascular risk ; postpartum screening ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    UGA Éditions
    Publication Date: 2024-04-02
    Description: Cet ouvrage raconte l’incroyable histoire du citoyen romain le plus célèbre du Moyen Âge, Cola di Rienzo (1313-1354). Homme instruit et brillant, il subjugue les foules par de beaux discours, rêve de rendre Rome à son antique gloire et prend le pouvoir en 1347. Il a alors trente-trois ans. Visionnaire politique, humaniste ou encore homme de foi attiré par des idéaux de réforme révolutionnaires, il est considéré à l’époque romantique comme un précurseur de l’Unité italienne. Personnalité complexe, ambitieux et plein de contradictions, il se met en scène dans de superbes cérémonies, s’imaginant déjà empereur. Il connaîtra toutefois une fin tragique. Cette nouvelle biographie illumine ce personnage hors du commun qui possédait l’art inné d’utiliser les mots pour séduire et convaincre. L’auteur décrypte les ressorts d’une propagande qui permit à cet homme du peuple d’accéder au pouvoir. Il nous amène ainsi à réfléchir sur le thème toujours d’actualité de la dangereuse puissance de la propagande et des rhétoriques populistes.
    Keywords: histoire médiévale ; Moyen Âge ; propagande ; empire Romain ; biographie ; tribun ; anonyme romain ; papauté ; rhétorique ; cité romaine ; politique ; pouvoir ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3K CE period up to c 1500
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Coronavirus disease 2019 (COVID-19) is a new respiratory disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused a global pandemic. COVID-19 patients often develop acute respiratory distress syndrome (ARDS), which involves acute and lethal respiratory failure. In a meta-analysis, the median incidence of ARDS in COVID-19 patients was found to be 35 (2-79)%, while the mortality rate in COVID-19-associated ARDS patients was found to be 39 (12.5-73.1)% (Hasan, et al. Expert Rev Repoir Med. 2020; 14: 1149). As of 12 December 2021, 270,373,764 cases had been confirmed as COVID-19 and 5,321,321 cases had resulted in death, according to the World Health Organization webpage. Various symptoms such as persistent fatigue, myalgia, and insomnia can persist after recovery from COVID-19; these symptoms are called “long COVID-19”. Patients with COVID-19 who survive but develop pulmonary fibrosis may experience persistent dyspnea upon exertion, a decrease in pulmonary function, and/or a radiological abnormal shadow. Antifibrotic drugs including nintedanib and pirfenidone are candidate drugs for the treatment of pulmonary fibrosis due to COVID-19; randomized controlled trials are ongoing. However, there are limited studies about respiratory disease caused by COVID-19. Given the clinical significance of this topic and its impact on clinical practice and public health, Medicina have published a Special Issue entitled “Respiratory Disease in the COVID-19 Era” with the aim of gathering accurate and up-to-date scientific information of this topic.
    Keywords: heart rate ; COVID-19 ; pulmonary rehabilitation ; COVID-19 vaccines ; adult ; pneumonia ; risk ; SARS-CoV-2 ; Pneumocystis jirovecii pneumonia ; interstitial pneumonia ; steroids ; immunosuppressive drugs ; spontaneous pneumomediastinum ; subcutaneous emphysema ; therapeutic plasma exchange ; ARDS ; inflammatory markers ; survival ; immunocompromised host ; Bruton’s tyrosine kinase ; persistent infection ; pulmonary paragonimiasis ; Paragonimus westermani ; post-COVID-19 condition ; delayed diagnosis ; case cluster ; Bamlanivimab ; Etesevimab ; lung ultrasound ; RT-qPCR ; HRCT ; diabetes mellitus ; computed tomographic severity score ; immunocompromised ; coronavirus disease 2019 ; hydroxychloroquine ; severe acute respiratory syndrome ; n/a ; diaphragm ; thoracic mobilization ; respiratory function ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine::MBNS Epidemiology & medical statistics
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: It is a great pleasure to provide you this Special Issue of Nutrients related to the 5th International Conference “Vitamin D—Minimum, Maximum, Optimum”, under the auspices of the European Vitamin D Association (EVIDAS). The conference and the forthcoming papers serve as an international forum for the presentation and discussion of current basic and clinical research in the field of vitamin D. Organizing this subsequent Special Issue was truly challenging, given that vitamin D has recently been shown by prestigious medical journals to be an epiphenomenon that coincides with diseases, and that the correction of vitamin D deficits has limited clinical meaning. On the other hand, it was recognized that vitamin D deficiency is a global health problem with potential negative consequences on health, welfare, and morbidity during growth and adulthood, therefore influencing healthcare services worldwide. Thus, due to mutually exclusive conclusions, it was essential to discuss and share scientific reports and evidence demonstrating both the benefits and lack thereof in relation to human health. Prof. Dr. Pawel Pludowski Guest Editor
    Keywords: vitamin D ; calcidiol ; supplementation ; COVID-19 ; RCT ; clinical trial ; cholecalciferol ; randomized controlled trial ; epidemiology ; mortality ; infections ; nutrition ; 25-hydroxyvitamin D ; infection ; study design ; clinical trials ; Alzheimer’s disease ; cancer ; cardiovascular disease ; diabetes ; hypertension ; Mendelian randomization ; vitamin D status ; prevalence ; female migrants ; United Arab Emirates ; blood pressure ; cardiovascular risk ; vitamin D deficiency ; recommendations ; guidelines ; treatment ; juvenile idiopathic arthritis ; calcium/phosphate metabolism ; methotrexate ; children ; inflammation ; pneumonia ; SARS-CoV-2 ; CYP24A1 ; pregnancy ; hypercalcemia ; fertility ; lactation ; intoxication ; idiopathic infantile hypercalcemia ; 25(OH)D ; B cell subsets ; inflammatory markers ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
    Language: English
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    Cornell University Press | Cornell University Press
    Publication Date: 2024-04-02
    Description: In the sixteenth and seventeenth centuries, Russians from all ranks of society were bound together by a culture of honor. Here one of the foremost scholars of early modern Russia explores the intricate and highly stylized codes that made up this culture. Nancy Shields Kollmann describes how these codes were manipulated to construct identity and enforce social norms—and also to defend against insults, to pursue vendettas, and to unsettle communities. She offers evidence for a new view of the relationship of state and society in the Russian empire, and her richly comparative approach enhances knowledge of statebuilding in premodern Europe. By presenting Muscovite state and society in the context of medieval and early modern Europe, she exposes similarities that blur long-standing distinctions between Russian and European history. Through the prism of honor, Kollmann examines the interaction of the Russian state and its people in regulating social relations and defining an individual's rank. She finds vital information in a collection of transcripts of legal suits brought by elites and peasants alike to avenge insult to honor. The cases make clear the conservative role honor played in society as well as the ability of men and women to employ this body of ideas to address their relations with one another and with the state. Kollmann demonstrates that the grand princes—and later the tsars—tolerated a surprising degree of local autonomy throughout their rapidly expanding realm. Her work marks a stark contrast with traditional Russian historiography, which exaggerates the power of the state and downplays the volition of society. ; In the sixteenth and seventeenth centuries, Russians from all ranks of society were bound together by a culture of honor. Here one of the foremost scholars of early modern Russia explores the intricate and highly stylized codes that made up this culture. Nancy Shields Kollmann describes how these codes were manipulated to construct identity and enforce social norms—and also to defend against insults, to pursue vendettas, and to unsettle communities. She offers evidence for a new view of the relationship of state and society in the Russian empire, and her richly comparative approach enhances knowledge of statebuilding in premodern Europe. By presenting Muscovite state and society in the context of medieval and early modern Europe, she exposes similarities that blur long-standing distinctions between Russian and European history.Through the prism of honor, Kollmann examines the interaction of the Russian state and its people in regulating social relations and defining an individual's rank. She finds vital information in a collection of transcripts of legal suits brought by elites and peasants alike to avenge insult to honor. The cases make clear the conservative role honor played in society as well as the ability of men and women to employ this body of ideas to address their relations with one another and with the state. Kollmann demonstrates that the grand princes—and later the tsars—tolerated a surprising degree of local autonomy throughout their rapidly expanding realm. Her work marks a stark contrast with traditional Russian historiography, which exaggerates the power of the state and downplays the volition of society.
    Keywords: History of specific lands ; Legal history ; Sociology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Peter Lang International Academic Publishers
    Publication Date: 2023-11-16
    Description: The NEUROGES® analysis system is an objective and reliable interdisciplinary research tool for analysis of body movement and gesture. The system has been field-tested on more than 500 individuals from cultures of five continents, including healthy adults and children as well as individuals with mental illness or brain damage, and further, on non-human primates. Following up on the first book on theoretical background of the NEUROGES® system, which was published in 2013, this book contains the complete coding manual for the application of the system in research including an interactive video learning tool with video examples of all NEUROGES® hand movement and gesture types, training videos, and a template file for the Multimedia Annotator ELAN.
    Keywords: algorithmic analysis ; Analysis ; Behavior ; Coding ; cognition ; Complete ; Gesture ; Hedda ; including ; interaction ; Interactive ; kinesic behaviour ; Lausberg ; Learning ; Manual ; mental state ; movement analysis ; NEUROGES® ; Nonverbal ; System ; Template ; Tool ; Video ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: The lifestyle associated with good quality of food is well known for its widely recognized health benefits, especially when rich in bioactive compounds. Reduced risks of some types of cancer and other diseases have been associated with the adoption of such a diet, as have increased antioxidants, inhibitors of lipid peroxidation, decrease of pro-inflammatory cytokine production, etc. The focus of this Special Issue of Toxins was to gather advances related to the cytotoxicity of natural toxins and the potential for the cytoprotection of natural compounds present in food or plants. In this context, this Special Issue of Toxins comprises eight original contributions. Special attention is given to Fridericia chica (Bignoniaceae) leaves grown in Colombia, extract from Polygonum cuspidatum, Artemisia annua and coffee extracts against mycotoxins´ effects. Studies of mycotoxins in different animal and human cell lines are also presented for zearalenone, beauvericin, α-zearalenol and β-zearalenol, among others.
    Keywords: nano-silicate platelets ; necroptosis ; reactive oxygen species ; endocytosis ; membrane integrity ; Apoptosis ; bovine mammary epithelial cells ; endoplasmic reticulum stress ; polydatin ; zearalenone ; beauvericin ; α-zearalenol ; coffee silverskin ; spent coffee ; SH-SY5Y cells ; mycotoxin ; apoptosis ; endothelial cells ; calcium ; autophagy ; granulosa cells ; PI3K-AKT-mTOR ; MAPK ; chicken ; PAT ; ROS ; oxidative stress ; mitochondrial oxidative phosphorylation ; cytotoxicity ; mycotoxins ; Fridericia chica ; protection ; extracts ; artemisinin ; anticancer effects ; stress granules ; alternative extraction procedures ; osteosarcoma cells ; HeLa cells ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
    Language: English
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