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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This Reprint Book provides recent studies addressing encapsulation systems for active compounds (e.g., drugs and food ingredients) to improve the quality of life around the world. The content may be helpful for the colleagues and students working on encapsulation of active compounds.
    Keywords: carboxymethyl chitosan ; mangosteen ; deodorant ; skin moisturizing ; trans-2-nonenal ; accelerated stability test ; guava ; carotenoids ; microencapsulation ; mucilage ; spray-drying ; aloe vera ; Opuntia ficus-indica ; ar-turmerone ; polymeric nanoparticles ; anticancer activity ; release study ; biodegradable polymers ; apple fiber ; trehalose ; sucrose ; blackberry phenolics ; blackberry volatiles ; starch ; Bisphenol A ; Moringa leaf extract ; encapsulating Moringa leaf extract ; nanoparticles ; alginate ; chitosan ; Ib-M peptides ; E. coli ; peptide stability ; polyethylene glycol methacrylate ; oregano ; phenolic compounds ; nanoencapsulation ; bioaccessibility ; curcumin ; zebrafish embryogenesis ; oxidative stress ; neuroprotection ; PCL nanoparticles ; paraquat ; grafted microparticles ; sodium hyaluronate ; crosslinked microparticles ; metronidazole adsorption ; adsorption isotherm ; adsorption kinetics ; metronidazole release ; polyelectrolyte ; complex coacervate ; polyamine ; stimulus-responsive materials ; controlled release ; encapsulation ; hybrids ; clay ; sodium alginate ; rosemary essential oil ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: The World Health Organization recommends the consumption of plant foods instead of animal-origin foods due to their high levels of saturated fat and cholesterol. Consumption of plant products has led to research on the beneficial properties of their components beyond basic nutrients. Vegetable-derived peptides have shown multifunctional effects related to chronic diseases, attracting interest from the food, nutraceutical, and pharmaceutical industries. This reprint highlights studies on various vegetable extracts, such as chestnut, quinoa, amaranth, buckwheat, and Protium heptaphyllum gum resin, which have demonstrated antimicrobial, anti-inflammatory, and cholesterol-regulating properties. Specific compounds derived from plants, such as methyl p-coumarate and lupin protein hydrolysate, have shown effectiveness in reducing inflammation and anxiety, respectively. A vegetable extract of rosemary has been studied for its potential to treat osteogenesis imperfecta. Moreover, this repprint reviews Lycium barbarum berries, essential oils from Annonaceae species, antioxidant compounds, phytosterols, and natural compounds for the prevention and treatment of oral mucositis was discussed. Overall, these studies suggest that vegetable-derived bioactive compounds could serve as new nutraceuticals to prevent and treat a wide range of chronic diseases.
    Keywords: hypercholesterolemia ; gene expression ; HMGCR ; PCSK9 ; PPARα ; enzymatic activity ; molecular docking ; statin ; monacolin ; breu branco ; seed storage proteins ; peptides ; anti-inflammatory ; antioxidant ; trypsin inhibitors ; quinoa ; amaranth ; buckwheat ; in vitro gastro-intestinal digestion ; natural products ; Brazilian species ; essential oil ; applications ; phytosterols ; neurodegeneration ; Alzheimer’s disease ; blood brain barrier ; obesity ; oxidative stress ; dyslipidemia ; diabetes ; enzyme-assisted extraction ; plant material ; phenolic compounds ; oligosaccharides ; prebiotic ; nanocellulose ; nanofibers ; fermentation ; sustainability ; cancer ; drug delivery ; oral mucositis ; treatment ; lupin ; protein hydrolysates ; anxiety ; ApoE−/− ; functional foods ; peptidomics ; rosemary extract ; collagen type I ; unfolded protein response ; autophagy ; proteasome ; skin fibroblasts ; apoptosis ; osteogenesis imperfecta ; asthma ; methyl p-coumarate ; Th2 cytokines ; eosinophil ; NF-κB ; Castanea sativa shells ; Subcritical Water Extraction (SWE) ; antimicrobial activity ; goji berries ; pro-healthy effects ; phenolics ; biological properties ; functional ingredients ; in vitro cultures ; Ruta montana ; coumarins ; alkaloids ; antibiofilm formation ; antibacterial activity ; antioxidant activity ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Introducing “A Feasible Approach for Natural Products to Treatment of Diseases”–an exploration of the therapeutic potential locked within nature’s abundant offerings. This comprehensive reprint delves into the fascinating realm of natural products, uncovering their inherent properties, mechanisms of action, and potential roles in effective disease management. Through extensive scientific research and reviews, the authors shed light on the immense potential of natural products as a viable approach to enhancing health and combating diseases. This reprint presents a diverse and multidimensional exploration, bridging the gap between traditional wisdom and contemporary scientific understanding and offering new avenues for healthcare professionals, researchers, and enthusiasts to harness the power of nature’s remarkable resources. As a catalyst for unlocking the healing potential of natural products, this reprint inspires further investigation and innovation, and drives us towards a future where their integration into mainstream healthcare becomes indispensable. Discover the possibilities and embark on a health and well-being journey with “A Feasible Approach for Natural Products to Treatment of Diseases”.
    Keywords: cancer immunotherapy ; fructan ; FT-IR ; mass spectrometry ; young green barley ; COVID-19 ; β-glucans ; immunomodulation ; anti-inflammation ; anti-oxidant ; ACE2 regulation ; impedance ; ECIS ; antitumor activity ; anticancer properties ; betulin ; betulinic acid ; Amadori rearrangement compounds ; barley ; anti-obesity ; arginyl-fructose ; adipogenic ; ergosta-5,7,22,24(28)-tetraenol (ERGT) ; cholesta-5,7,22,24-tetraenol (CHT) ; ergosterol biosynthesis ; antimetabolite ; suicide substrate ; Trypanosoma brucei ; coronavirus SARS-CoV-2 ; main protease ; Saussurea costus ; molecular docking ; GC-MS profiling ; Molineria recurvata ; diabetic nephropathy ; urinary biomarkers ; inflammation ; oxidative stress ; walnut ; Juglans regia ; high-fat diet ; insulin resistance ; cognitive function ; JNK/NFκB pathway ; Citri Reticulatae Pericarpium ; flavonoids ; anticancer ; mechanism ; phenotype ; Angelica sinensis polysaccharide ; Astragalus membranaceus polysaccharide ; hexokinase 2 ; glycolysis ; JAK2/STAT3 pathway ; liver regeneration ; Holoptelea integrifolia ; MMP-9 ; wound healing ; friedelin ; oxalactam A ; macrolactam ; anti-Rhizoctonia solani ; Penicillium oxalicum ; molecular dynamics ; non-alcoholic fatty liver disease (NAFLD) ; natural products ; terpenoids ; mechanisms ; treatment ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint reviews a crop pest management use for several essential oils and the properties of an excellent lemon (citral) source. Research is reported on the biological properties of enhanced lemon oil along with the human intake of citrus beverages and the less common medicinal mastiha oil. Oils and hydrolates of rosemary and lavender were analyzed by headspace/GC-MS to better define their antibacterial, antioxidant and cytotoxic activities, and yeast particle encapsulation was investigated for the controlled release of bioactive terpenes.
    Keywords: monoterpenes ; mastiha oil ; absorption ; Citrus limon (L.) Osbeck ; essential oil ; citral ; nutraceuticals ; inflammation ; oxidative stress ; terpenes ; yeast particles ; antimicrobial ; anthelmintic ; prodrug ; beverages ; Citrus ; coumarins ; furocoumarins ; polymethoxyflavones ; linear retention indices ; liquid chromatography ; tandem mass spectrometry ; multiple reaction monitoring ; quality control ; Backhousia citriodora ; lemon myrtle ; lemon oils ; geranial ; neral ; iso-citrals ; citronellal ; flavor ; fragrance ; biological activity ; Lavandula angustifolia ; Rosmarinus officinalis ; essential oils ; hydrolates ; chemical analysis ; volatile compounds ; phytochemicals ; synergism ; fractional inhibitory concentration ; insect mortality rate ; phytopathogenic fungi ; insect pests ; pesticide resistance ; fungicide resistance ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PN Chemistry
    Language: English
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint includes 16 original articles published in a Special Issue that focuses on the pathological significance of amyloid-β in neurodegenerative diseases, such as Alzheimer’s disease, the main cause of dementia. Collections in this reprint provide novel insights into the underlying mechanisms and therapeutic potentials of repositioning drugs and new agents for Alzheimer’s disease and related dementias. These findings are expected to contribute to the development of innovative strategies for the prevention and treatment of such diseases.
    Keywords: activation phenotypes ; microglia ; neuroinflammation ; immunohistochemistry ; temporal cortex ; Alzheimer’s disease ; amyloid ; amyloid β-protein (Aβ) ; mAb158 ; oligomers ; protofibrils ; amyloid aggregation ; supported lipid bilayers ; time-lapse AFM ; molecular dynamics simulation ; alzheimer’s disease ; amyloid β ; bryostatin-1 ; ECE1 ; iPS ; nELAV ; neurotoxicity ; oligomer ; protein kinase C ; α-secretase ; APP mutation ; recessive inheritance ; familial Alzheimer’s disease ; Aβ oligomers ; amyloid imaging ; microbiota ; bacterial amyloid ; FUBA ; curli ; CsgA ; amyloid beta ; oxidative stress ; supplement ; phosphodiesterase III inhibitor ; cerebral micro-hemorrhage(s) ; cerebral amyloid angiopathy ; amyloid-β protein ; transgenic mice ; NMR ; CD ; Aβ ; β-amyloid peptide ; α/β-discordant ; Dutch-type mutation ; E22Q ; FAD ; Amyloid β ; Polyphenol ; Pro-oxidant ; Alzheimer’s Disease ; molecular imaging ; amyloid β-peptides ; islet amyloid polypeptide ; high-speed atomic force microscopy ; amyloid PET ; tau PET ; amyloid precursor protein ; mutation ; cerebellum ; PBB3 ; PiB ; axon ; traditional medicines ; Polygalae Radix ; diosgenin ; naringenin ; kihito ; amyloid-β ; antimicrobial ; antiviral ; antimicrobial peptide ; neurodegenerative disease ; misfolding ; fluorescence microscopy ; FRET ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented.
    Keywords: ferulic acid ; total body irradiation ; bone marrow microenvironment ; stem cell senescence ; bone marrow injury ; reactive oxygen species ; antioxidant defense system ; planarians ; model animal ; irradiation ; regeneration ; radioprotection ; radiation ; melatonin ; nDNA-repair ; mtDNA-mutations ; oxidation stress ; protection ; mitigation ; H2O2 ; ATP ; MDA ; GSH ; X-ray radiation ; 3T3 fibroblasts ; proliferation ; apoptosis ; cellular stress ; senescence ; peroxiredoxin 6 ; Prdx6 ; radioprotector ; pharmacologic ascorbate ; vitamin C ; pancreatic cancer ; Auranofin ; thioredoxin ; thioredoxin reductase ; peroxiredoxin ; nuclear and radiological emergencies ; radioprotectors ; radiomitigators ; radionuclide scavengers ; radiation biodosimetry ; Olea europaea L. cv. Caiazzana ; oleacein ; ionising radiation ; cancer ; radiotherapy ; normal tissue ; radiosensitization ; radiomodulation ; proteomic analysis ; oxidative modification profiling ; serum albumin ; amino acid sequences ; radiation biomarker ; human lactoferrin ; acute gamma irradiation ; C57Bl/6 mice ; survival rate ; open field test ; spleen ; serum homeostasis ; leukocytes ; stilbenoid ; electron paramagnetic resonance (EPR) ; FT-IR ; electron beam radiation ; radioresistance ; oxidative phosphorylation ; oncometabolites ; radiation response ; bioinformatics ; oxidative stress ; transcriptomics ; radiobiology database ; gene signature ; ionizing radiation ; intestine ; mucositis ; microbiome ; microbiota ; dysbiosis ; bacterial dietary supplement ; radiomitigator ; hyperthermia ; combination therapy ; synergistic effect ; oxygenation ; hypoxia ; immune response ; Tameron ; antioxidant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: The reprint provides the most relevant and state-of-the-art in the field, including recent developments in the production of natural compounds from various bioresources, and their formulations as bioactives. This reprint also covered the engineered approaches for enhanced biological properties and their potential applications. Identification of novel compounds and bioprocess tools to improve the quantity and quality of bioactive compounds and their formulations are exclusively covered in this reprint.
    Keywords: anti-solvent ; enzymatic saccharification ; EMIM-Ac ; ethanol ; ionic liquid ; lignocellulosic biomass ; recycling ; agro-industry ; microencapsulation ; bioactive compounds ; in vitro digestion ; yogurt ; cannabis ; cannabinoids ; postharvest ; drying ; curing ; storage ; biosynthesis ; pre-treatments ; sorption isotherm ; Raphanus sativus L. ; recombinant IFN-α2a ; apoptosis ; antiviral and antitumor activity ; Japanese knotweed rhizome bark ; SARS-CoV-2 ; COVID-19 ; virus neutralization test ; nano-formulation ; nutraceuticals ; prebiotics ; nanofabricated delivery system ; liposomes ; nano-emulsions ; Abelmoschus manihot ; neurodegenerative disease ; oxidative stress ; proliferation ; inflammation ; nucleotide excision repair ; Actinosynnema pretiosum ; ansamitocin P-3 ; ssgA ; AdpA ; morphological differentiation ; pomegranate ; pomace ; extraction ; biological activity ; functional beverages ; sensory quality ; vitamins ; formulation ; homogeneous systems ; hydrophile–lipophile balance ; Emblica officinalis ; phytochemicals ; hyperlipidemia ; pharmacology ; nanoformulation ; Prunus mume ; vasorelaxant ; hypertension ; angiotensin receptor blockers ; agro-waste ; valorization ; value-added bioproducts ; micro/nano encapsulation ; agri-food-pharma applications ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint presents the published papers of a Special Issue titled Antioxidant Activity of Essential Oils, of the journal Antioxidants, MDPI. Obviously, essential oils are a point of huge interest, due to them being rich in bioactive substances (with their recognised antioxidant, immunomodulatory, antibacterial, antiviral, etc., effects) and are also used extensively in the beauty/cosmetic industry, food products, etc. Considering the global trend of "return to nature", both in eating habits/nutrition, and in the adjuvant therapies (implying essential oils) addressed in the case of numerous diseases, and taking into account the interest of the authors who submitted their papers, the current topic can be considered to be of great interest and with increased and promising potential for future research.
    Keywords: allyl compounds ; molecular dynamic ; antioxidant enzyme ; oxidative stress ; phytochemical study ; Artemisia judaica ; essential oil ; wound healing ; inflammatory markers ; antibiofilm activity ; antioxidant activity ; Ammi visnaga L. ; chemical composition ; gas chromatography-mass spectrometry ; circular economy ; volatile compounds ; antioxidants ; pro-oxidants ; enzymatic activity ; gas chromatography ; proanthocyanidins ; polyphenols ; Salvia officinalis ; chemical analysis ; aromatherapy ; inhalation ; TBARS ; FRAP ; colour parameter ; linseed and vitamin E ; oregano and rosemary ; microbiological profile ; beef meat ; phytochemicals ; medicinal plants ; plant-based nanostructures ; eco-friendly nanotherapeutics ; therapeutics ; phytobiotics ; apiaceae family ; Valeriana pilosa ; antioxidant activities ; molecular docking ; Embelia ribes Burm. ; Vidanga ; essential oils/extracts ; embelin ; vilangin ; pharmacology ; phytochemistry ; plant-based compounds ; natural products ; Amazon ; medicinal plant ; bioactive compounds ; S. edelbergii ; essential oils ; GC-MS analysis ; in vitro and in vivo biological activities ; antioxidant ; phytotoxic ; molecular modeling ; virtual ligand screening ; Amazonian natural products ; Artemia salina ; 1,8-cineole ; (Z)-α-trans-bergamotene ; citrus essential oils ; natural aromatic compounds ; therapeutic effects of citrus EOs ; characterization of citrus EOs ; new species ; Rosmarinus officinalis ; Salvia rosmarinus ; aromatic herbs ; wastes ; residues ; LC-HRMS/MS ; sweet orange ; cold pressing ; hydrodistillation ; scavenging activity ; reducing capacity ; virulence factors ; quorum sensing ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Nowadays, diet-related non-communicable diseases and their complications are one of the most important public health problems worldwide. Food supplements and functional foods are considered food products which contribute to the achievement of optimal nutritional well-being, health status, and quality of life through reducing the risk of diseases and promoting the appropriate function of human organs and systems. Nowadays, the assessment of these functional foods and the study of their implications in nutrition and health are important challenges in societies of developed countries where consumers increasingly demand foods with added value beyond the provision of nutrients and the satisfaction of appetite. In this reprint, the characterization of the nutritional composition and phytochemicals of functional foods and food supplements as well as the evaluation of their potential health benefits in different disorders and diseases through clinical trials or preliminary studies are addressed.
    Keywords: food supplement ; folic acid ; pregnancy ; food safety ; health claims ; nutrition ; Amazonian fruits ; composition ; metabolic effects ; royal jelly ; acetylcholine ; fatty acid ; ophthalmology ; dry eye ; magnesium ; pharmacy ; food supplements ; drugstore ; functional foods ; healthy eating ; credibility ; extrinsic attributes ; conjoint analysis ; Mediterranean diet ; phytonutrients ; dietary recommendations ; healthy diet ; polyphenols ; flavonoids ; carotenoids ; organosulfur ; caffeine ; antidiabetic activity ; antioxidant activity ; inhibition of α-glucosidase ; inhibition of α-amylase ; inhibition of collagenase ; kombucha ; bacteria ; yeast ; metagenome ; metabolome ; tea polyphenols ; antioxidants ; Glossogyne tenuifolia ; exercise ; forelimb grip strength ; lactate ; ammonia ; creatine kinase ; medium-chain triglycerides (MCTs) ; obesity ; energy expenditure ; diet-derived fat ; postprandial resting metabolism ; sedentary ; octanoic acid ; decanoic acid ; creatine ; magnetic resonance spectroscopy ; cost-effectiveness ; brain ; muscle ; healthcare ; anthocyanins ; organosulfur compounds ; tannins ; phenolic acids ; Persea americana ; non-alcoholic liver disease ; liver enzymes ; inflammation ; oxidative stress ; novel foods ; novel ingredients ; extracts ; risk assessment ; dietary supplements ; HPLC ; food authenticity ; neural tube defects ; food ; food analysis ; food ingredients ; infant formula ; kynurenic acid ; (poly)phenol-based supplement ; pharmacokinetics ; urinary excretion ; bioavailability ; inter-individual variability ; non-invasive brain stimulation ; TMS ; a-tDCS ; indicaxanthin ; brain food ; cortical excitability ; homeostatic plasticity ; trans-resveratrol ; regulation ; labels ; nutrition claims ; high-performance thin-layer chromatography ; HPTLC ; glutamine ; intestinal stem cells ; crypt ; proliferation ; burns ; micronutrient ; health claim ; labeling ; European legislation ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC4 Cultural studies: food and society
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Perennial woody plants usually face multifactorial adverse conditions during their long lifespan, which impairs their growth and productivity. To cope with these adverse conditions, trees deploy morphyological, physiological and molecular responses to adapt to the environmental constraints. By using high-throughput sequencing and bioinformatic approaches, many hub genes that are involved in stress response were identified. In recent years, with the advantages of transgenic technology in woody plants, many candidate genes participating in stress responses were functionally characterized and showed great potential for tree improvement under different stresses. On the other hand, cultivation strategies (including beneficial microorganism investigation, beneficial microorganism inoculation, mixed forest and so on) also play crucial roles in tree improvement under abiotic and biotic stress.
    Keywords: Salix matsudana ; NaCl stress ; salt tolerance index ; salt tolerance gene ; transcriptome sequencing ; gene ; water deficit ; fertilization ; aquaporins ; auxin ; abscisic acid ; poplar ; walnut oil ; fatty acid ; micronutrients ; secondary metabolites ; variation ; genetic effect ; climatic factors ; SpsNAC005 gene ; Populus × hopeiensis Hu & Chow ; Salix ; stress tolerance ; Juglans regia ; biomass ; soil contamination ; oxidative stress ; antioxidant enzymes ; Santalum album L. ; auxin response factors ; qRT-PCR ; drought ; phytoremediation ; root architecture ; antioxidant enzyme activity ; chlorophyll ; photosynthesis ; fine-root distribution ; plant-available water ; hydraulic characteristics ; Robinia pseudoacacia ; Loess Plateau ; nitrogen forms ; Cunninghamia lanceolata ; Schima superba ; morphological characteristics of root system ; pecan ; scion growth ; regulation ; epigenetics ; whole-genome bisulfite sequencing (WGBS) ; mulberry ; MaTCP transcription factor ; drought tolerance ; root development ; transcription factor ; PtrWRKY51 ; salt tolerance ; photosynthetic rate ; water-use efficiency ; Paulownia fortunei ; PP2C family ; identification ; hormone treatment ; expression analysis ; drip fertigation ; optimized furrow fertilization ; soil nitrogen ; fine root traits ; poplar plantation ; Camellia oil ; foliar fertilizer ; nutrient-poor ; physiology ; organ-specific ; secondary metabolism ; transcriptome ; zinc stress ; sexual dimorphism ; siblings ; gene regulation ; ROS scavenging ; Populus × euramericana ; Camellia oleifera ; boron deficiency ; arbuscular mycorrhizal fungi (AMF) ; root morphology ; physiological parameters ; grafting ; salt stress ; gas exchange ; chlorophyll fluorescence ; Hibiscus syriacus Linn. ; Hibiscus hamabo Sieb. et Zucc ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: We are facing a complicated public health issue in the form of global drug shortages, including antibiotics. Synthetic biology empowers the next generation of antibiotics development, bringing us into a new era.
    Keywords: global regulator ; milbemycins ; Streptomyces bingchenggensis ; SspH ; actinorhodin ; avermectin ; ceftriaxone ; hepatotoxicity ; metal complexes ; oxidative stress ; Streptomyces ; comparative transcriptome ; polyether antibiotics ; salinomycin ; exporter genes ; spectroscopic studies ; antioxidant capacities ; hepatic functions ; cancer cells ; cefotaxime ; Inonotus hispidus ; natural product ; biological activity ; medicinal fungi ; phytochemicals ; antimicrobial agents ; biosynthetic pathway ; secondary metabolites ; 1-benzazepine ; l-kynurenine ; genome mining ; biosynthesis ; iterative methyltransferase ; genetic dereplication ; cyclodipeptide ; OSMAC ; cytotoxicity ; Zymomonas mobilis ; antibiotic resistance ; ampicillin ; genome editing ; CRISPR−Cas12a ; resistance selection markers ; traditional Chinese medicine ; antifungal drug ; immune regulation ; combination of drugs ; fungal infection ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: The purpose of this Special Issue, “The Role of Nutrition in Cardiometabolic Health: Experimental, Clinical, and Community-Based Evidence”, is to publish a focused, coherent, impactful, and well-cited volume on how nutrition influences diverse cardiometabolic risk factors. Cardiometabolic diseases such as coronary heart disease, stroke, type 2 diabetes mellitus, and obesity are the leading causes of death worldwide. In recent years, dietary habits have shifted all over the globe. At the same time, a constantly growing body of evidence demonstrates the role of caloric intake and dietary composition as determinants of cardiometabolic health. A suboptimal diet predisposes to a myriad of cardiometabolic risk factors such as impaired glucose metabolism, insulin resistance, dyslipidemia, and high blood pressure. The goal of this Special Issue is to provide rigorous evidence from novel experimental and observational studies that support the association between dietary factors and cardiometabolic risk and evaluate the diverse diet-related risk pathways.
    Keywords: Diet ; nutrition ; supplements ; caloric restriction ; cardiometabolic ; obesity ; diabetes ; glucose metabolism ; insulin resistance ; lipid profile ; vascular biology ; endothelial function ; cardiovascular ; nutrigenomics ; epigenetics ; weight loss ; metabolism ; coronary artery disease ; stroke ; hypertension ; atherosclerosis ; inflammation ; oxidative stress ; phytochemicals ; bariatric surgery ; microbiome ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The survival of plants under stressful environments requires the study of the mechanisms that help in reversing the adverse impacts of reactive oxygen species (ROS) excessively generated under these conditions. Understanding the mechanisms helps in adopting strategies to induce such mechanisms for the better acclimation of plants. These ROS, if not scavenged, cause damage of cellular components, including lipids, proteins, nucleic acids, and metabolites, and, in extreme cases, even the death of cells in plants. Confronted with abiotic stress, there is an initial elevation in ROS that activates redox signaling to initiate defense in plants through the activation of antioxidant activity. The improvement in the capacity of antioxidant machinery is one of the essential strategies with which to develop tolerance and relieve the pressure of abiotic-stress-induced oxidative changes for the survival of plants. This reprint provides knowledge on the following aspects: Impact of abiotic stress factors and the response of antioxidant machinery to changing abiotic stress conditions, as well as strategies with which to strengthen antioxidant machinery for the survival of plants; Strategies to improve the tolerance mechanisms of plants against abiotic stress factors; Roles and the mechanisms of the plant signaling molecules/growth modifiers/mineral nutrients/hormones/other elicitors in relieving the impacts of abiotic stresses; The utilization of approaches such as genomics, metabolomics, transcriptomics, proteomics, ionomics, and nutiomics to strengthen antioxidant machinery and make plant life easier under abiotic stress conditions.
    Keywords: tomato ; photosynthesis ; root growth ; oxidative damage ; melatonin ; drought ; gene expression ; toxic metals/metalloid ; nanoparticles ; phytohormones ; phytoremediation ; reactive oxygen species ; antioxidant enzymes ; heavy metal stress ; ubiquitination ; protein degradation ; gas exchange features ; osmotic adjustment ; water deficiency ; water-use-efficiency ; antioxidant defense ; arabidopsis ; bioinformatic analysis ; SlBAG genes ; SlBAG9 ; Solanum lycopersicum ; antioxidants ; oxidative stress ; marker-free transgenic rice ; mature seed-derived calli ; pea DNA helicase 45 ; salinity stress tolerance ; ethylene response factor ; flooding stress ; metallothionein ; monodehydroascorbic acid reductase ; resistant cultivar ; respiratory burst oxidase ; sensitive cultivar ; biochemical metabolites ; plant growth ; stigmasterol ; wheat ; polyamine ; iron-deficiency ; transcriptomics ; BAG9 ; Hsps ; thermotolerance ; ethylene ; hydrogen sulfide ; nitric oxide ; rice ; Arabidopsis ; metabolome ; ROS ; rohitukine ; ascorbate peroxidase ; catalase ; hydrogen peroxide ; NADP dehydrogenases ; NADPH oxidase ; salt stress ; superoxide dismutase ; seed priming ; spermine ; chromium ; S1fa transcription factor ; cell wall ; yeast ; antioxidant enzyme ; heat stress ; betaine ; seed germination ; physiology ; biochemistry ; Hibiscus cannabinus ; physiological changes ; bioactive constituents ; antioxidant capacity ; bioactive molecules ; carotenoids ; flavonoids ; osmotic stress ; phenolic acids ; secondary metabolites ; exogenous spermidine ; lettuce ; transcriptome ; vanadium stress ; sweet potato ; antioxidant defense system ; stomatal traits ; antioxidant systems ; Cu stress ; leucine ; nitrogen metabolism ; peach ; polyamine uptake protein ; Put2 ; ascorbate ; Dittrichia ; glutathione ; thallium toxicity ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This reprint represents a collection of scientific papers belonging to a Special Issue of Antioxidants entitled "Advances in the Astonishing World of Phytochemicals: State-of-the-Art for Antioxidants". Several studies have revealed that plants are a source of a plethora of bioactive compounds, such as phytohormones, glycosides, terpenoids, alkaloids, phenolic compounds, and essential oils, with a strong potential impact in the fields of pharmaceutics and agriculture. These phytochemicals represent a valuable weapon that plants use in self-defense in order to counteract the effects of abiotic stress disturbing the delicate equilibrium between the generation of reactive oxygen species (ROS) and antioxidant defense systems. In recent years, interest in this area of research has been increasing due to the multifaceted properties of natural compounds with antioxidants having anticancer, anti-inflammatory, and antimicrobial activity. Therefore, understanding the underlying mechanism of their action is crucial to establishing their real potential in applied sciences. This reprint focuses on the most recent advances in the study of antioxidant molecular mechanisms activated by phytochemicals, with potential pharmacological and agricultural applications. We thank all the authors for their contribution to the research topic of this reprint and all editorial staff for their valuable support.
    Keywords: antioxidant response element (ARE) ; Nrf2 signaling pathway ; bioactive byproducts ; proanthocyanidins ; oxidative stress mechanisms ; thinned apples ; polyphenols ; anti-oxidant ; anti-inflammatory ; NRF2 ; NF-κB ; proteomics ; antioxidants ; acetylcholinesterase ; 1,1-diphenyl-2-picrylhydrazyl ; HPLC ; medicinal plants ; oxidative stress ; cytotoxicity ; hepatoprotective effects ; HeLa cancer ; inflammation ; mass spectrometry ; oxidation ; prostate cancer ; phytochemical ; phenolic acids ; phenolic mixtures ; interaction effect ; antioxidant activity ; FRAP ; ORAC ; Achillea millefolium ; yarrow extract ; H. pylori ; supercritical anti-solvent fractionation ; anti-inflammatory activity ; antibacterial activity ; A. gangeticus ; protein and dietary fiber ; minerals ; phytochemicals ; HPLC-UV DPPH ; ABTS+ ; PA profiles ; NaCl ; Mexican Gordolobo ; supercritical CO2 extraction ; fatty acids ; biomass valorization ; mountain pepper ; rosella ; strawberry gum ; lemon aspen ; flavonoids ; anthocyanins ; bioavailability ; LC-MS/MS ; microalgae ; exopolysaccharides ; phycoerythrin ; biocompatibility ; wound healing ; Echinacea purpurea extracts ; fractions ; phenols/carboxylic acids ; alkylamides ; human primary macrophages ; pressurized liquid extraction ; seaweeds ; green extraction technique ; bioactive compounds ; functional ingredients ; food packaging ; future trends ; tomato-based products ; metabolic syndrome ; HFD ; antioxidant capacity ; phytonutrients ; yarrow ; fragmentation pathway ; electrospray ionization ; secondary metabolites ; horseradish ; mass spectra ; kaolinite ; phyto-carrier system ; phytocompounds ; methyl gallate ; autophagy ; apoptosis ; p53 ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
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  • 18
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories.
    Keywords: developmental origins of health and disease (DOHaD) ; gut microbiota ; hypertension ; short chain fatty acid ; oxidative stress ; probiotics ; prebiotics ; renin–angiotensin system ; fibroblast growth factor-23 ; left ventricular hypertrophy ; renin–angiotensin–aldosterone system ; losartan ; canrenone ; Hyp mice ; X-linked hypophosphatemia ; hairless SHRM ; cold acclimation ; cardiac Cx43 ; extracellular matrix ; thyroid hormones ; SHR ; sacubitril/valsartan ; ARNI ; ivabradine ; remodelling ; cardiac dysfunction ; fibrosis ; angiotensin II ; angiotensin 1-7 ; knock-out ; genome-editing ; SHRSP ; Dahl SS ; foetal programming of hypertension ; sympathetic neurotransmission ; sympathetic innervation ; vascular remodelling ; foetal undernutrition ; old SHR ; antihypertensive therapy ; blood pressure monitoring ; LV hypertrophy ; ECM markers ; cardiac fibrosis ; SHR-CRP ; SGLT-2 inhibitor ; gene expression ; age ; lipid metabolism ; nitric oxide ; l-NAME ; rostral ventrolateral medulla ; aging ; reactive oxygen species ; NADPH oxidase activator 1 ; mitochondria ; chloride ; calcium-activated chloride channel ; Na+–K+–2Cl− cotransporter 1 ; TMEM16A ; smooth muscle ; fetal undernutrition programming ; cross-fostering ; lactation period ; cardiovascular hypertrophy ; adipose tissue browning ; cardiovascular disease ; catecholamines ; liquid chromatography–tandem mass spectrometry ; SGLT-2 inhibition ; proteinuria ; uninephrectomized salt-loaded ; two-kidney ; one-clip hypertension ; fawn-hooded hypertensive rat ; ApoE KO ; apolipoprotein E knockout mice ; atherosclerosis ; Na,K-ATPase ; TCTP ; TCTP-overexpressing transgenic mice ; translationally controlled tumor protein ; TCTP-TG ; experimental hypertension ; bone ; rats ; taurine ; magnesium ; 24 h urine(24U) ; stroke-prone spontaneously hypertensive rat ; young SHR ; combination therapy ; treatment effect ; systolic blood pressure ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In this Special Issue, we aim to represent the vibrant state of protein structure studies at the end of 2021. Recent decades have brought significant changes to the protein structure research field. Thanks to the genome projects and advances in structure determination methods, the number of solved protein structures has increased significantly. Protein structure research is experiencing a new renaissance, and in 2020 the number of deposited structures in the PDB database reached a new record. An assortment of many new frontiers are presented in this collection. A single Special Issue cannot give a comprehensive overview of a large field such as proteins science, but we aim to give a broad overview of current research.
    Keywords: configurational entropy ; force fields ; intrinsically disordered proteins ; protein folding ; NMR ; high hydrostatic pressure ; thermodynamic stability ; α-helical bundle ; Li-Fraumeni syndrome ; hereditary breast cancer ; germline TP53 missense variants ; quantitative prediction model ; protein conformation ; protein–protein interactions ; protein–protein binding ; protein–protein complex ; coarse-grained modeling ; multiscale modeling ; UFM1 ; UBA5 ; UFC1 ; protein-protein interactions ; complex structure ; oxidative stress ; Nrf2 ; Keap1 ; nuclear magnetic resonance spectroscopy ; hydrogen/deuterium exchange ; mass spectrometry ; circular dichroism ; intrinsically disordered ; bifidobacteria ; fucosidases ; glycosyl hydrolases ; conserved domains ; human milk ; analytical ultracentrifugation ; CO2 concentrating mechanism ; diffusion-ordered NMR spectroscopy ; electrospray ionization mass spectrometry ; homotetramer ; manganese ; metalloprotein ; photosynthesis ; small-angle X-ray scattering ; C1q ; calcium binding proteins ; genetic variation ; otoconia ; otolin-1 ; OTOL1 ; site-directed mutagenesis ; thermal shift assay ; B.1.1.7 ; B.1.617.2 ; COVID-19 ; E484Q ; T478K and L452R mutation ; N501Y mutation ; spike protein ; tetrabromobisphenol A ; tetrabromobisphenol S ; erythrocyte membrane ; retardants ; erythrocytes ; protein–ligand interactions ; protein dynamics ; FK506-binding protein ; FKBP12 ; FKBP51 ; oxidative folding ; glutathionylation ; nitrosylation ; cysteine reactivity ; ribosomal exit tunnel ; transient complex ; glutathione ; phosphorylation ; transmembrane proteins ; saturation mutagenesis ; deep sequencing ; residue packing ; deep learning ; convolutional neural network ; bidirectional long-short term memory ; protein ; prediction ; contact ; distance ; alphafold ; ProSPr ; CASP ; dataset ; retrainable ; mutual synergetic folding ; solvent accessibility of peptide bonds ; inter-subunit interaction ; solvent-accessible surface area ; Shannon information entropy ; amino acid composition ; glucose ; GlcNAc ; galactose ; GalNAc ; mannose ; xylose ; fucose ; Neu5Ac ; glucuronate ; iduronate ; tetrahydropyran ; entropy ; free energy ; free energy landscape ; energy-dependent protein folding ; co-translational protein folding ; molecular chaperones ; physical model of protein folding ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 20
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The exposure of animals to environmental stresses (restraint, bad housing conditions, irradiation, pollution, diseases, and heat stress) and endogenous stresses (metabolic and physiological disorders) can seriously disrupt the redox homeostasis, leading to impairments in animals’ health and overall performance. Under these circumstances, the self-antioxidant defense system may not be enough to neutralize ROS effects. In this context, the utilization of an exogenous source of antioxidants, mainly dietary sources, may present an effective and cost-effective solution. There are a plethora of substances, either naturally occurring or synthesized (organic acids, minerals, vitamins, hormones, and specific feed additives originating from plants such as essential oils and polyphenols), known for their antioxidant activity, that can be used to maintain adequate redox status in animals in order to preserve their well-being and/or productivity. This area of research still needs more investigations in order to clearly elucidate the effective antioxidant substances that could be used in practical applications, with an emphasis on their biological mechanisms during different physiological conditions and health statuses. We intend to bring together current research concerning the role of antioxidant substances either from natural sources or those synthesized for improving animal production, reproduction, health, and welfare.
    Keywords: antinutrient ; enzyme ; fermentation ; fiber ; gut health ; microbiota ; meta-analysis ; poultry ; prebiotic ; antioxidants ; growth ; heat stress ; rabbit ; selenium ; spirulina ; zinc ; broiler ; dietary protein level ; phytogenic feed additive ; growth performance ; immune response ; exercise ; endurance ; undenatured type II collagen ; anti-inflammatory ; cardiac injury markers ; oxidative stress ; histopathology ; Bcl-2 ; Bax ; TGF-β1 ; date palm (pollen extract) ; doxorubicin ; nitrocompounds ; nitropropanol ; nitroethanol ; biochemical parameters ; oregano essential oil ; temperature ; sea bass ; cornelian cherry extract ; glucose transporter ; gene expression ; oxidative biomarker ; chicken ; cyclic heat stress ; Spirulina platensis ; redox status ; serum metabolites ; blood hematology ; meat quality ; fipronil ; boswellic acid ; PCNA ; semen ; fertility-related markers ; Oreochromis niloticus ; antioxidant ; hematology ; nitric oxide ; lysozyme ; copper toxicity ; vitamin C ; vitamin E ; hematological parameters ; phytogenic ; phenols ; antimicrobial activity ; immunity ; phenolic antioxidant ; olive oil ; caprine ; spermatozoa ; Bayesian inference ; Duroc breed boars ; biochemistry ; blood parameters ; feeding time ; correlation coefficients ; Turraea fischeri ; polyphenolics ; semen cryopreservation ; sperm ultrastructure ; antioxidant biomarker ; apoptosis ; nano particles ; performance ; blood ; pathogens ; quails ; carcass traits ; blood biochemical constituents ; abdominal fat color ; meat fatty acid profile ; liver histology ; broilers ; Eimeria tenella ; broiler chickens ; oocyst shedding ; volatile fatty acids ; feed efficiency ; cecal health ; active yeast ; antioxidant status ; nutrient density ; trace element ; laying hen performance ; high temperature ; inflammation ; cryopreservation ; tannin ; polyphenols ; semen additives ; carcass ; fructooligosaccharide ; haemato-biochemical parameters ; cecal microbiota ; propolis ; bee pollen ; productive performance ; fertility ; Holstein ; folic acid ; pregnancy ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSV Zoology and animal sciences
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Plants under natural conditions often face multiple stresses, including drought, salinity, temperature extremes, submergence stress, bacteria, viruses, fungi, insects, etc. These biotic and abiotic stresses negatively influence plant growth and productivity. Various approaches have recently been used to overcome stresses in plants. It is necessary to evaluate and explore how diverse molecular techniques can be applied to different biological studies to improve biotic and abiotic stress tolerance in plants. This will help reduce production losses and increase crop tolerance to various stresses. It is now the time to make a difference by developing plants that can withstand biotic and abiotic stresses.
    Keywords: antioxidants ; drought ; oxidative stress ; pearl millet ; redox implications ; ROS ; chlorophyll fluorescence efficiency ; photosynthetic responses ; enzyme activity ; sugarcane ; smut ; circadian clock ; reactive oxygen species ; Al-induced PCD ; photoperiodism ; peanut ; phylogenetic ; virus-induced gene silencing ; transgenic lines ; physiological and biochemical analysis ; Glycine max L. ; PR proteins ; chitinase ; genome-wide ; plant stresses ; crop residues ; profitability ; soil fertility ; soil biology ; allelopathy ; heat shock protein 20 ; maize ; abiotic stress ; yeast-one-hybrid ; abiotic stresses ; cotton ; hormones ; signaling pathway ; WRKY ; papaya (Carica papaya) ; brassicales ; late embryogenesis abundant protein ; orthogroup ; expression profile ; artificial light ; auxins ; chicory ; callus cells ; inulin ; plant growth regulators ; milk thistle ; secondary metabolites ; ecotypes ; salinity ; growth attributes ; biotic stress ; phenolic compounds ; seaweed ; Dendrobium catenatum ; lipase ; multi-omics ; expression pattern ; gene family ; bio-fertilizer ; ionic homeostasis ; organic amendments ; vermicompost ; cold stress ; PKS5 ; stomatal aperture ; microbiota ; natural farming ; physical factors ; physiological changes ; signal transduction and stressed conditions ; Rhizobium leguminosarum ; PGPR ; Triticum aestivum L. ; cadmium stress ; tolerance ; ascorbate ; glutathione ; malondialdehyde ; chlorophylls ; disease gradient ; disease outbreak ; Puccinia ; wheat stripe rust ; plant epidemic ; dispersal ecology ; alternative plant vitrification solution ; ammonium-free medium ; cytotoxicity ; droplet-vitrification ; endangered species ; liquid overlay ; regrowth medium ; within-plant phenotypic plasticity ; combined stresses ; additive ; antagonistic and synergic effects ; VOCs ; potassium ; soybean ; water logging ; yield ; non-thermal plasma ; plant defense ; glucosinolates ; nitriles ; RNA sequencing ; Arabidopsis thaliana ; Bt toxins ; Cry1Ah1 transgenic poplar ; ecology ; environment ; rhizosphere ; candidate genes ; drought tolerance ; crop improvement ; climate change ; adaptation ; Chenopodium quinoa Willd. ; genotypes ; Sahara ; Algeria ; chitosan ; pathogen ; sustainable ; plant protection ; tomato ; melatonin ; photosynthesis ; climate changes ; antioxidant system ; Malus seedlings ; NaCl treatments ; membrane damage ; osmotic regulation ; archives ; botanical collection ; Greece ; landscape ; pre-rebellion period ; wheat ; priming ; Aspergillus niger ; qRT-PCR ; wilting ; TLP ; β-1,3-glucanase ; biostimulants ; biofertilizers ; soil microorganisms ; phytostimulator ; jewel sweet potato ; shoot tip ; axillary bud ; different MS salts concentration ; micropropagation ; plant performance ; C4 species ; heterozygosity ; transient soil salinity ; soil layers ; desertification ; arid regoins ; total flavonoid ; phenolics ; antioxidant activity ; centella ; Na+ content ; molecular markers ; MAS ; oilseeds ; SSRs ; molecular breeding ; dehydration-responsive element binding (DREB) transcription factors ; gene expression ; mosses ; stress tolerance ; common centaury ; salinity stress ; antioxidative protection ; sodium nitroprusside ; proteomic analysis ; drought stress ; sorghum ; RNS ; RSS ; signaling ; post-translational modification ; microorganisms ; stressful conditions ; sustainability ; nutrition ; Brassicaceae ; Cicer arietinum L. ; chlorophyll a fluorescence transient ; physiological and biochemical traits ; high temperature ; chocolate spot disease ; Botrytis fabae ; faba bean ; antioxidant enzymes ; protein banding and anatomy ; actinobacteria ; Streptomyces tuirus ; chilli fruit rot ; Colletotrichum scovillei ; Colletotrichum truncatum ; Fusarium oxysporum ; liquid bio-formulation ; corn smut ; fungus infection ; MDA ; proline ; quality ; halophytes ; Tripolium pannonicum ; hydrogen peroxide ; cell wall extensibility ; cell wall polysaccharide ; coleoptile ; growth inhibition ; lead (Pb) ; rice ; Bactrocera oleae ; spinosad ; kaolin ; organic oliviculture ; chlorophyll fluorescence ; leaf gas exchange ; physiological traits ; BAG (Bcl-2-associated anthanogene) family proteins ; molecular chaperone ; metabolomics ; metabolic responses ; metabolites variation ; surveillance ; Candidatus Liberibacter asiaticus ; comprehensive control ; distribution ; screen house ; Copper hyperaccumulation ; stress mitigation ; EDTA and IAA ; sunflower ; Fusarium wilt ; conventional breeding ; molecular makers ; QTLs ; genomics ; transcriptomics ; metabolomics and proteomics ; bread wheat ; AMF ; zinc ; growth parameters ; osmolyte ; osmoprotector ; ionic attributes ; PGPBs ; growth-promoting fungi ; crop productivity ; plant tolerance ; arbuscular mycorrhizal fungi ; aerobic rice ; soil enzymes ; phosphorus utilization ; P-deficient ; plant growth promotion ; chickpea ; selection indices ; drought tolerant genotypes ; abiotic and biotic stress ; CRISPR ; mega nucleases ; TALEN ; ZFN ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Reprint Book provides recent studies addressing encapsulation systems for active compounds (e.g., drugs and food ingredients) to improve the quality of life around the world. The content may be helpful for the colleagues and students working on encapsulation of active compounds.
    Keywords: carboxymethyl chitosan ; mangosteen ; deodorant ; skin moisturizing ; trans-2-nonenal ; accelerated stability test ; guava ; carotenoids ; microencapsulation ; mucilage ; spray-drying ; aloe vera ; Opuntia ficus-indica ; ar-turmerone ; polymeric nanoparticles ; anticancer activity ; release study ; biodegradable polymers ; apple fiber ; trehalose ; sucrose ; blackberry phenolics ; blackberry volatiles ; starch ; Bisphenol A ; Moringa leaf extract ; encapsulating Moringa leaf extract ; nanoparticles ; alginate ; chitosan ; Ib-M peptides ; E. coli ; peptide stability ; polyethylene glycol methacrylate ; oregano ; phenolic compounds ; nanoencapsulation ; bioaccessibility ; curcumin ; zebrafish embryogenesis ; oxidative stress ; neuroprotection ; PCL nanoparticles ; paraquat ; grafted microparticles ; sodium hyaluronate ; crosslinked microparticles ; metronidazole adsorption ; adsorption isotherm ; adsorption kinetics ; metronidazole release ; polyelectrolyte ; complex coacervate ; polyamine ; stimulus-responsive materials ; controlled release ; encapsulation ; hybrids ; clay ; sodium alginate ; rosemary essential oil ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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  • 23
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The reprint provides the most relevant and state-of-the-art in the field, including recent developments in the production of natural compounds from various bioresources, and their formulations as bioactives. This reprint also covered the engineered approaches for enhanced biological properties and their potential applications. Identification of novel compounds and bioprocess tools to improve the quantity and quality of bioactive compounds and their formulations are exclusively covered in this reprint.
    Keywords: anti-solvent ; enzymatic saccharification ; EMIM-Ac ; ethanol ; ionic liquid ; lignocellulosic biomass ; recycling ; agro-industry ; microencapsulation ; bioactive compounds ; in vitro digestion ; yogurt ; cannabis ; cannabinoids ; postharvest ; drying ; curing ; storage ; biosynthesis ; pre-treatments ; sorption isotherm ; Raphanus sativus L. ; recombinant IFN-α2a ; apoptosis ; antiviral and antitumor activity ; Japanese knotweed rhizome bark ; SARS-CoV-2 ; COVID-19 ; virus neutralization test ; nano-formulation ; nutraceuticals ; prebiotics ; nanofabricated delivery system ; liposomes ; nano-emulsions ; Abelmoschus manihot ; neurodegenerative disease ; oxidative stress ; proliferation ; inflammation ; nucleotide excision repair ; Actinosynnema pretiosum ; ansamitocin P-3 ; ssgA ; AdpA ; morphological differentiation ; pomegranate ; pomace ; extraction ; biological activity ; functional beverages ; sensory quality ; vitamins ; formulation ; homogeneous systems ; hydrophile–lipophile balance ; Emblica officinalis ; phytochemicals ; hyperlipidemia ; pharmacology ; nanoformulation ; Prunus mume ; vasorelaxant ; hypertension ; angiotensin receptor blockers ; agro-waste ; valorization ; value-added bioproducts ; micro/nano encapsulation ; agri-food-pharma applications ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 24
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The evaluation of vascular stiffness is becoming increasingly important in cardiovascular research to determine the properties of the arterial tree and clinically assesspatients. Current research addresses and debates some unresolved technical and methodological issues with measuring arterial stiffness, with the purpose of making it more reliable and clinically suitable. This Special Issue focuses on new methodological advances in vascular stiffness, as well as preclinical and clinical applications. A privileged space is reserved for new data and targeted reviews of the application of arterial stiffness and early vascular ageing measures regarding problems such as the stratification of risk of special populations and specific diseases.
    Keywords: arterial stiffness ; Arteriograph ; obstructive sleep apnea (OSA) ; continuous positive airway pressure (CPAP) ; metabolic syndrome (MS) ; adherence ; abdominal aortic aneurysm ; diabetes mellitus type 2 ; inflammatory marker ; vascular stiffness ; cardiovascular death ; degenerative aortic stenosis ; heat failure episodes ; pulsatile index ; resistive index ; aortic valve replacement ; transcatheter aortic valve implantation ; energy drinks ; pediatrics ; prevention ; aorta ; arterial distensibility ; augmentation index ; blood pressure amplification ; cardiovascular prevention ; elastic modulus ; pulse wave analysis ; pulse wave velocity ; prediabetes ; 11-dh-thromboxane ; cardiovascular risk ; IMT ; familial hypercholesterolemia ; selective LDL apheresis ; PCSK9 inhibitor monoclonal antibody ; thyroid ; parathyroid ; cardiovascular disease ; carotid distensibility ; carotid strain ; Young’s elastic modulus ; carotid compliance ; systemic sclerosis ; scleroderma ; vascular ageing ; central hemodynamics ; gut microbiota ; gut microbiome ; inflammation ; oxidative stress ; altitude ; altitude sickness ; aortic stiffness ; aortic distensibility ; atrial natriuretic factor ; blood pressure ; vascular age ; risk factors ; carotid distension ; primary prevention ; CAVI ; CAVI0 ; PWV ; comorbidity ; aging ; echo-tracking ; vascular ultrasound ; arterial properties ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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  • 25
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Europe’s zero-pollution agenda should depart from an understanding of how the European citizens’ bodies are polluted by synthetic chemicals and prioritize the reduction of the chemical body burden and associated health impacts. In this context, Human Biomonitoring (HBM) is an important and valuable tool for assessing the internal exposure of humans resulting from aggregated exposure to chemicals. Though many obstacles still hinder the use of HBM data, the growing availability of HBM data offers an opportunity for improving and refining Human Risk Assessment. This Special Issue intends to illustrate, using case studies, how HBM data could be used to better estimate internal exposure and resulting risks. Case studies on exposure from consumer products (cosmetic products, non-food products, etc.) or exposures via food or water in the general population or among workers contributed to better identifying the obstacles hindering a broader use of HBM data in RA. A better understanding of population exposure and the exposure of vulnerable groups against health-based human biomonitoring guidance values also provides the basis for effective risk management to reduce impacts on health. I would like to thank all the authors for submitting their original contributions to this Special Issue. We greatly appreciate the support of all the reviewers who spent time evaluating and improving the quality of the manuscripts. I would also like to thank the editors of Toxics for their kind invitation and Selena Li of the Toxics Editorial Office for her invaluable support.
    Keywords: biomonitoring ; nanoparticles ; lung diseases ; mineralogical analysis of broncho-alveolar lavages ; occupational exposure ; human biomonitoring ; UV filters ; benzophenone-3 ; HBM4EU ; risk assessment ; RCR ; margin of safety ; oxidative stress ; MDA ; systematic review ; meta-analysis ; urinary biomarker ; reference range ; general population ; pesticides ; exposure ; operators ; workers ; residents ; bystanders ; tree-grown produce ; fruits ; vine ; systemic exposure ; paints production ; TiO2 powders ; biological monitoring ; exhaled breath condensate ; occupational health ; ortho-toluidine ; urinary mass-balance ; PBPK modelling ; human biomonitoring (HBM) ; internal exposure ; biomarkers ; endocrine disruptors ; bisphenol A (BPA) ; bisphenol S (BPS) ; bisphenols ; human biomonitoring guidance value (HBM-GV) ; physiologically based pharmacokinetic modelling (PBPK) ; organophosphorus flame retardants ; dietary exposure ; children ; malondialdehyde ; reference values ; benzene ; COVID-19 pandemic ; lockdown ; Rome ; elements ; urban traffic ; metabolomics ; dimethylformamide ; DMF ; HBM-GV ; guidance value ; biomarker ; toxicokinetics ; health effects ; liver ; carcinogenicity ; reprotoxic effects ; chlorpyrifos ; pesticide exposure ; pesticide risk assessment ; mercury ; methylmercury ; European Human Biomonitoring Initiative (HBM4EU) ; co-exposure ; workplace ; mixture risk assessment (MRA) ; adipose tissue ; meta-regression ; partition coefficients ; persistent organic pollutants ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This reprint includes 16 original articles published in a Special Issue that focuses on the pathological significance of amyloid-β in neurodegenerative diseases, such as Alzheimer’s disease, the main cause of dementia. Collections in this reprint provide novel insights into the underlying mechanisms and therapeutic potentials of repositioning drugs and new agents for Alzheimer’s disease and related dementias. These findings are expected to contribute to the development of innovative strategies for the prevention and treatment of such diseases.
    Keywords: activation phenotypes ; microglia ; neuroinflammation ; immunohistochemistry ; temporal cortex ; Alzheimer’s disease ; amyloid ; amyloid β-protein (Aβ) ; mAb158 ; oligomers ; protofibrils ; amyloid aggregation ; supported lipid bilayers ; time-lapse AFM ; molecular dynamics simulation ; alzheimer’s disease ; amyloid β ; bryostatin-1 ; ECE1 ; iPS ; nELAV ; neurotoxicity ; oligomer ; protein kinase C ; α-secretase ; APP mutation ; recessive inheritance ; familial Alzheimer’s disease ; Aβ oligomers ; amyloid imaging ; microbiota ; bacterial amyloid ; FUBA ; curli ; CsgA ; amyloid beta ; oxidative stress ; supplement ; phosphodiesterase III inhibitor ; cerebral micro-hemorrhage(s) ; cerebral amyloid angiopathy ; amyloid-β protein ; transgenic mice ; NMR ; CD ; Aβ ; β-amyloid peptide ; α/β-discordant ; Dutch-type mutation ; E22Q ; FAD ; Amyloid β ; Polyphenol ; Pro-oxidant ; Alzheimer’s Disease ; molecular imaging ; amyloid β-peptides ; islet amyloid polypeptide ; high-speed atomic force microscopy ; amyloid PET ; tau PET ; amyloid precursor protein ; mutation ; cerebellum ; PBB3 ; PiB ; axon ; traditional medicines ; Polygalae Radix ; diosgenin ; naringenin ; kihito ; amyloid-β ; antimicrobial ; antiviral ; antimicrobial peptide ; neurodegenerative disease ; misfolding ; fluorescence microscopy ; FRET ; n/a ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions.
    Keywords: COVID-19 ; drug repurposing ; topological data analysis ; persistent Betti function ; SARS-CoV-2 ; network-based pharmacology ; combination therapy ; nucleoside GS-441524 ; fluoxetine ; synergy ; antidepressant ; natural compounds ; QSAR ; molecular docking ; drug repositioning ; UK Biobank ; vaccine ; LC-2/ad cell line ; drug discovery ; docking ; MM-GBSA calculation ; molecular dynamics ; cytotoxicity assay ; GWAS ; multiple sclerosis ; oxidative stress ; repurposing ; ADME-Tox ; bioinformatics ; complex network analysis ; modularity clustering ; ATC code ; hidradenitis suppurativa ; acne inversa ; transcriptome ; proteome ; comorbid disorder ; biomarker ; signaling pathway ; druggable gene ; drug-repositioning ; MEK inhibitor ; MM/GBSA ; Glide docking ; MD simulation ; MM/PBSA ; single-cell RNA sequencing ; pulmonary fibrosis ; biological networks ; p38α MAPK ; allosteric inhibitors ; in silico screening ; computer-aided drug discovery ; network analysis ; psychiatric disorders ; medications ; psychiatry ; mental disorders ; toxoplasmosis ; Toxoplasma gondii ; in vitro screening ; drug targets ; drug-disease interaction ; target-disease interaction ; DPP4 inhibitors ; lipid rafts ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Preeclampsia is a hypertensive disorder of pregnancy, diagnosed after the 20th week of gestation in women experiencing new-onset hypertension along with symptoms affecting the liver, kidneys, or brain. In some cases, women with preeclampsia develop novel seizures or unexplained coma, at which time they are diagnosed with eclampsia. The mechanisms contributing to preeclampsia and eclampsia are not fully elucidated, although the placenta seems to play a critical role. Previous studies suggest that improper placentation stimulates mitochondrial dysfunction and the exaggerated release of placental-derived molecules including inflammatory cytokines, anti-angiogenic factors, reactive oxygen species, and cell-free nucleic acids into the maternal circulation that cause systemic vascular dysfunction. These, along with maternally derived molecules, act in concert, leading to hypertension and target organ damage during pregnancies complicated by preeclampsia and eclampsia.In this reprint, we present the original research articles and review papers published as part of the Special Issue: "The Pathophysiology of Preeclampsia and Eclampsia" in Cells.
    Keywords: pre-eclampsia ; eclampsia ; pulmonary oedema ; biobank ; database ; placental ischemia ; seizure ; ASIC2a ; pregnancy ; RUPP ; pentylenetetrazol ; melatonin ; extracellular vesicle ; exosome ; preeclampsia ; misfold proteins ; endothelial cell activation ; p21Cip1/CDKN1A ; trophoblasts ; hypoxia ; trophoblast organoids ; fusion ; angiotensin II ; AGTR1 (angiotensin II receptor type 1) ; bradykinin ; BDKRB2 (bradykinin receptor B2) ; AT1R-B2R heteromer (protein complex formed of AT1R-B2R) ; G-protein-coupled receptor ; protein aggregation ; ARRB (beta-arrestin) ; early-onset preeclampsia ; hemorheology ; red blood cell aggregation ; red blood cell deformability ; erythrocyte ; hypertension ; IL-2 ; inflammation ; oxidative stress ; sFlt-1 ; NLRP3 ; nitric oxide ; endothelial dysfunction ; neuroinflammation ; blood–brain barrier ; cerebral edema ; gestation ; vessel ; blood pressure ; placenta ; trophoblast ; fetal growth restriction ; maternal chronic venous disease (CVeD) ; anti-inflammation ; antioxidant ; ischaemia ; vitamin E ; glucose transporter 9 ; GLUT9 ; uric acid ; cardiac dysfunction ; placental factors ; activin A ; G-protein-coupled receptors ; GPCR ; weighted gene correlation network analysis ; WGCNA ; blood-brain barrier ; in vitro studies ; cerebral biomarkers ; NfL ; tau ; NSE ; S100B ; nebivolol ; adrenoceptor ; obesity ; biomarkers ; adipokines ; adiponectin ; leptin ; ROS ; angiogenic factors ; hypoxia/reoxygenation ; sFlT-1/PlGF ratio ; primary trophoblast ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Plants show different strategies for coping with stress factors. They develop various types of adaptations to avoid the stressor or to activate defense reactions consisting of damage repair and running alternative metabolic pathways. This Special Issue, “What Makes the Life of Stressed Plants a Little Easier? Defense Mechanisms against Adverse Conditions”, contains several original articles that deal with such changes that occur at the level of the transcriptome, proteome, and metabolome, as well as structural adaptations in response to a stress factor. It also provides four review articles on drought stress, metal stress, various abiotic stress responses of cultivated beet, and crosstalk between Ca2+ and other regulators in stress signaling.
    Keywords: water deficit ; cold stress ; water content ; photosynthesis ; anatomy ; secondary metabolites ; antioxidants ; bioaccumulation ; copper toxicity ; hydroponics ; translocation factor ; F-box protein ; SCF complex ; stress response ; WD40 repeat-like protein ; wheat ; peroxidase ; ascorbate peroxidase ; catalase ; yield index ; Brachypodium distachyon ; cold acclimation ; microbiome ; amplicon and shotgun sequencing ; metagenomics ; Pseudomonas ; Streptomyces ; beet cultivation ; abiotic stress ; alkaline ; cold ; heat ; heavy metals ; stress tolerance ; ultraviolet radiation ; acidic soils ; abiotic stress tolerance ; proteomic studies ; two dimensional electrophoresis (2-DE) ; × Triticosecale Wittmack ; auxin-related compound ; Bryophyllum calycinum ; indole-3-acetic acid ; methyl jasmonate ; plant hormone dynamics ; secondary abscission ; PERK ; kinase ; RT-qPCR ; promoter ; drought ; heat stress ; Ca2+ ; abiotic stress response ; Ca2+ sensors ; signal transduction ; abiotic stress tolerance calcium ; abscisic acid ; chloroplast degeneration ; malondialdehyde ; nanoparticles ; oxidative stress ; drought stress ; osmolytes ; antioxidant enzymes ; phytohormones ; antifungal secondary metabolites ; biocontrol ; abnormal germ tube suppression of appressoria ; Streptomyces sp. ; adaptation ; priming ; defense mechanisms ; metallophyte ; phytoremediation ; tolerance ; Armeria maritima ; electrical conductivity ; functional differences ; ion accumulation ; non-ionic osmolytes ; osmotic adjustment ; potassium ; salinity ; sodium ; tissue culture ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Air pollution and the changing climate are some of the greatest threats to the health and functioning of forest ecosystems, strongly jeopardizing their ecological and economic functions as well as services. The impact of increasing temperatures and extreme weather events (droughts, storms, temperature and precipitation extremes) on the vitality of forest trees is often difficult to separate from the impact of pollution, such as nitrogen deposition and tropospheric ozone, as they can exhibit synergistic effects. The use of indicators is elementary in modern forest ecophysiological research, as they help us to disentangle complex interactions between trees and various stress-inducing factors as well as better estimate the level of damage to trees and forest ecosystems.Eleven papers are included in this Special Issue, with wide-ranging topics from various disciplines but centered around tree responses to environmental stress. The task of this Special Issue is twofold: one, to remind us that a better understanding of the physiological processes influencing tree vitality under the changing climate and air pollution pressures requires considerable research efforts and constant advancements in research methods and approaches; two, to highlight the fact that the environmental pressures instigating the use of tree stress response indicators are more present than ever, and will likely continue to affect tree vitality in the foreseeable future.
    Keywords: defoliation ; monitoring ; tree vitality ; drought ; climate change ; forest decline ; extreme climate events ; tree mortality ; climate response ; radial increment ; dendrochronology ; Fagaceae ; osmolytes ; antioxidant ; phytohormones ; trade-off mechanisms ; stress marker ; oxidative stress ; tropospheric ozone ; leaf symptoms ; PODy ; water stress ; risk assessment ; climate–growth relationship ; climate signal ; tree-ring width ; basal area increment ; blue intensity ; daily climatic data ; cadmium ; nickel ; phytoremediation ; plant hormones ; polyamines ; poplar ; Populus deltoides ; antioxidative enzymes ; chlorophyll ; defoliated trees ; hydrogen peroxide ; lipid peroxidation ; nutrient concentration ; Pinus spp. ; Quercus spp. ; undefoliated trees ; pine ; BAI ; isotopes ; iWUE ; water and thermal stress ; SPEI ; Poland ; foliar composition ; stoichiometry ; ICP Forests ; tree decline ; Quercus brantii ; cellular characteristics ; calcium oxalate crystals ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNA Agribusiness and primary industries::KNAL Forestry industry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In this Special Issue, we aim to represent the vibrant state of protein structure studies at the end of 2021. Recent decades have brought significant changes to the protein structure research field. Thanks to the genome projects and advances in structure determination methods, the number of solved protein structures has increased significantly. Protein structure research is experiencing a new renaissance, and in 2020 the number of deposited structures in the PDB database reached a new record. An assortment of many new frontiers are presented in this collection. A single Special Issue cannot give a comprehensive overview of a large field such as proteins science, but we aim to give a broad overview of current research.
    Keywords: configurational entropy ; force fields ; intrinsically disordered proteins ; protein folding ; NMR ; high hydrostatic pressure ; thermodynamic stability ; α-helical bundle ; Li-Fraumeni syndrome ; hereditary breast cancer ; germline TP53 missense variants ; quantitative prediction model ; protein conformation ; protein–protein interactions ; protein–protein binding ; protein–protein complex ; coarse-grained modeling ; multiscale modeling ; UFM1 ; UBA5 ; UFC1 ; protein-protein interactions ; complex structure ; oxidative stress ; Nrf2 ; Keap1 ; nuclear magnetic resonance spectroscopy ; hydrogen/deuterium exchange ; mass spectrometry ; circular dichroism ; intrinsically disordered ; bifidobacteria ; fucosidases ; glycosyl hydrolases ; conserved domains ; human milk ; analytical ultracentrifugation ; CO2 concentrating mechanism ; diffusion-ordered NMR spectroscopy ; electrospray ionization mass spectrometry ; homotetramer ; manganese ; metalloprotein ; photosynthesis ; small-angle X-ray scattering ; C1q ; calcium binding proteins ; genetic variation ; otoconia ; otolin-1 ; OTOL1 ; site-directed mutagenesis ; thermal shift assay ; B.1.1.7 ; B.1.617.2 ; COVID-19 ; E484Q ; T478K and L452R mutation ; N501Y mutation ; spike protein ; tetrabromobisphenol A ; tetrabromobisphenol S ; erythrocyte membrane ; retardants ; erythrocytes ; protein–ligand interactions ; protein dynamics ; FK506-binding protein ; FKBP12 ; FKBP51 ; oxidative folding ; glutathionylation ; nitrosylation ; cysteine reactivity ; ribosomal exit tunnel ; transient complex ; glutathione ; phosphorylation ; transmembrane proteins ; saturation mutagenesis ; deep sequencing ; residue packing ; deep learning ; convolutional neural network ; bidirectional long-short term memory ; protein ; prediction ; contact ; distance ; alphafold ; ProSPr ; CASP ; dataset ; retrainable ; mutual synergetic folding ; solvent accessibility of peptide bonds ; inter-subunit interaction ; solvent-accessible surface area ; Shannon information entropy ; amino acid composition ; glucose ; GlcNAc ; galactose ; GalNAc ; mannose ; xylose ; fucose ; Neu5Ac ; glucuronate ; iduronate ; tetrahydropyran ; entropy ; free energy ; free energy landscape ; energy-dependent protein folding ; co-translational protein folding ; molecular chaperones ; physical model of protein folding ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The Special Issue titled “Recent Advances in Long-Acting Drug Delivery and Formulations” encompasses versatile and innovative research domains of oral, ocular, brain, and topical delivery systems and chemical approaches (e.g., prodrugs), highlighting the progress made in identifying excipients (e.g., basic amino acids to ameliorate gastric side effects of non-steroidal anti-inflammatory drugs (NSAIDs)), polymers, and molecular targets to achieve more effective sustained release systems and safer medicine. In this Special Issue, 78 authors have contributed, with eleven original research articles spanning five continents (Asia, Europe, Africa, North America, and Australasia) providing important insights into the pharmaceutical sciences.
    Keywords: drug delivery ; nanotechnology ; alzheimer’s disease ; Amyloid-β ; solid lipid nanoparticles ; SHSY5Y cells ; altretamine ; cancer therapy ; sustained delivery ; hydroxyapatite nanoparticles ; chemical precipitation method ; polymeric film ; diabetes mellitus ; skin regeneration ; wound healing ; sodium alginate ; sodium carboxy methyl cellulose ; microwave ; cross-linking ; ketoprofen ; L-arginine ; L-lysine ; tris ; basic amino acids ; writhing ; gastric ulcer ; chitosan ; 1,3,5-benzene tricarboxylic acid ; hydrogels ; rheology ; alginate ; BSA ; Maillard reaction ; age-related-macular degeneration ; drug release ; fenofibrate ; retinal cells ; HIV ; long-acting subcutaneous injection ; raltegravir ; cyclisation-activated prodrugs ; β-blockers ; NSAIDs ; corticosteroids ; ocular delivery ; drug permeability ; QSPR ; MLR ; Alzheimer’s disease ; GSK-3β-Wnt/β-catenin ; PERK/CHOP/Bcl-2 ; oxidative stress ; cocoa ; vinpocetine ; diabetes ; salbutamol ; skeletal muscle atrophy ; sarcosine ; metabolomics ; factorial design ; controlled release ; topical delivery ; texture analysis ; bioadhesion ; intermolecular interactions ; hydroxypropyl methylcellulose ; polyvinylpyrrolidone ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Several factors have been identified as interfering with the success, rehabilitation, and fitness of athletes from childhood to adulthood, as well as in para-sport, and special populations, according to research. The performance and health of this population are affected by the relationships between stress, maturation, training load, and recovery. Environmental approaches aim to increase efficiency and physiological adaptations in this sense. In various situations and conditions, however, this stimulus–performance–adaptation relationship varies.As a result, we received contributions related (but not limited) to the following topics: training load monitoring; stress and physiological responses during exercise or sports; recovery process after exercise; changes after stress and/or training load; physiology of training in health and sports performance.
    Keywords: visceral adipose tissue ; military ; metabolic syndrome ; cut-off points ; DXA ; warm-up ; muscle force ; performance ; resistance training ; thermal imaging ; physiology ; backstroke ; breaststroke ; start ; sink ; cortisol ; people with disabilities ; physical activities ; South Korea ; social determinants of health ; focus group interviews ; Paralympic Games ; Tokyo 2020 ; sociodemographic ; well-being ; resilience ; social support ; athletes ; disability ; performance indicators ; sports ; footwork ; reaction time ; agility ; physical activity environment ; relative importance ; priority ; pro bono ; intention ; pre-service physical activity instructor ; theory of planned behavior ; leisure time physical activity ; volunteering ; swimming ; social inclusion ; adapted physical activity ; respite care ; altitude ; hemoglobin ; erythropoietin ; hypoxia ; maximum volume of oxygen ; para powerlifting ; athletes with disabilities ; scoping review ; PAGER framework ; bibliometrics ; physical fitness ; body composition ; health ; measurement ; Down syndrome ; load-velocity relationship ; autoregulation ; load monitoring ; fixed-loading ; Wingate anaerobic performance ; paralympic sport ; para-rowing ; bibliometric analysis ; back pain ; sport ; sleep deficiency ; aerobic exercise ; oxidative stress ; hs-CRP ; stress ; hormones ; salivary glands ; endocrine ; autonomic nervous system ; immune system ; disabled athletes ; infection ; lymphocytes ; cytokines ; narrative review ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences::MFG Physiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This collection of articles provides an overview of the current and future methods for applying a personalized medicine approach to the diagnosis, management, and treatment of autism spectrum disorder.
    Keywords: fecal metabolites ; ASD ; microbiome ; gastrointestinal symptoms ; Fisher Discriminant Analysis ; digital biomarkers ; wearables ; time series analysis ; autism ; social dyads ; socio-motor parameters ; network connectivity ; non-linear complex dynamics ; stochastic analysis ; autism spectrum disorders ; copy number variants ; females ; Array-Comparative Genomic Hybridization (Array-CGH) ; autism spectrum disorder ; Ehlers-Danlos syndrome ; hypermobility spectrum disorders ; autonomic disorder ; mast cell activation syndrome ; genetic testing ; chromosomal microarray analysis ; whole exome sequencing ; whole genome sequencing ; clinical utility ; polygenic risk scores ; Temple Grandin ; biomarker ; omics ; precision medicine ; proteomics ; transcriptomics ; epigenetics ; metabolomics ; patient stratification ; mitochondria ; oxidative stress ; prenatal environment ; immune dysfunction ; immunoglobulin G ; intravenous immunoglobulin ; energy metabolism ; fatty acid oxidation ; acyl-carnitines ; resveratrol ; integrative ; model ; concomitant ; condition ; disorder ; autism spectrum disorder (ASD) ; genomics ; personalized treatment strategy ; single nucleotide polymorphisms ; clinical decision support tool ; ADHD ; PANDAS ; OCD ; anxiety ; folate receptor alpha ; folates ; pregnancy ; brain development ; fetal development ; cobalamin ; glutathione ; methylation ; methylcobalamin ; redox metabolism ; locked-in network syndrome ; resting-state functional magnetic resonance imaging ; temporal lobe epilepsy ; amygdala ; brain ; COVID-19 ; children ; cytokines ; flavonoids ; inflammation ; luteolin ; mast cells ; microglia ; SARS-CoV-2 ; stress ; nutraceuticals ; survey ; vitamins ; minerals ; B12 ; folinic acid ; quality of life ; parents ; intervention ; systematic review ; medical claims ; logistic regression analysis ; retrospective analysis ; associated risk ; monoamine neurotransmitters ; neurotransmitter deficiency ; cerebral folate deficiency ; folate receptor alpha autoantibodies ; leucovorin ; α-amylase ; cortisol ; heart rate variability ; neuromodulation ; sleep anxiety ; transdermal electrical neuromodulation ; neurostimulation ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: The close relationship between food intake and health promotion is not new; it dates back to Hippocrates’s famous “let food be your medicine and medicine be your food”, which is still as timely as ever. In recent years, some scientific evidence has supported this statement, showing that dietary plant extracts, or bioactive compounds isolated therefrom, are able to prevent or slow down the progression of chronic and degenerative diseases, making them particularly interesting from a nutraceutical point of view. On the other hand, extensive chemical investigations of functional plant extracts’ constituents are needed to rationalize certain bioactivity, in terms of efficacy and safety.
    Keywords: antioxidant effect ; lectins ; nanoliposomes ; purity grade ; quercetin ; trans-aconitic acid ; anthocyanins ; antioxidant activity ; bioactive compounds ; colorants ; fruit juices ; polyphenols ; wild blueberry ; antidiabetic ; cardioprotective ; functional foods ; nutraceuticals ; okra ; phytotherapy ; Jamaican cherry ; fermentation ; Lactobacillus plantarum ; antioxidant ; food nutrition improvement ; okra mucilage ; okra polysaccharides ; biopolymer ; α-amylase activity ; α-glucosidase activity ; antidiabetic activity ; biodegradable ; edible film ; release ; pectin ; sodium caseinate ; oil oxidation ; waste biomass ; coffee ; Coffea arabica ; phenolic ; free-radical scavenging ; iron chelating ; cytotoxic ; plant secondary metabolites ; antiviral activity ; food ; noroviruses ; MNV ; FCV ; yogurt ; betalains ; encapsulation ; lyophilization ; ionizing radiation ; radioprotection ; flavonoids ; plant extracts ; oxidative stress ; zebrafish embryo ; carotenoids ; Trapa bispinosa Roxb. ; polyphenol ; ellagitannin ; gallotannin ; α-glucosidase inhibitor ; advanced glycation end products (AGEs) ; antiglycation effect ; LC/UV/ESIMS analysis ; anti-diabetic ; abscisic acid ; Diabetes mellitus ; molecular docking ; phytohormones ; spray drying ; vegetable powders ; beetroot ; natural colorants ; violet betalain pigments ; bioactivity ; medicinal plants ; wild fruits ; industrial crops ; PCA ; HCA ; phenols ; TEAC ; roasting ; GAE ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: With the continuous improvement of people's living standards, the concern for food nutrition and safety has gradually increased. Consumers increasingly need to replace synthetic food additives with natural components extracted from food. Polysaccharides, starch, protein, pectin, and fibre are major types of biopolymer components in foods. They not only provide people with energy and nutrition, but are also used in food processing as natural additives due to their gelling, emulsifying, and film-forming properties, etc. They are characterised by high biocompatibility, low cost, and ease of access. Some natural components isolated from raw food materials have some drawbacks, such as low solubility and instability under certain conditions, which limit their application in food processing. Currently, many researchers are focusing on the modification, food technology, and future industry of polysaccharides, starch, protein, etc. These studies help to obtain the changed physicochemical and enhanced functional properties of these components, and further promote their high-value utilization in the food field. This Special Issue brings together 34 articles regarding the latest advances in the properties of polysaccharides, starch, protein, pectin, and fibre in food processing, from the improvements of the physical properties of major food components and biological activity studies to their applications in food preservation.
    Keywords: polysaccharide ; antibacterial activity ; toxicity ; body health ; gut microbiota ; pre-gelatinization ; thermal properties ; rheology ; structural properties ; microstructure ; starch gel ; polysaccharides ; inflammatory bowel disease ; mechanism ; polyphenol oxidase ; kudzu ; thermostability ; thermal inactivation kinetics ; food constituents ; conformation ; dietary fiber ; fermentation patterns ; cyanidin-3-O-glucoside ; polymeric proanthocyanidin ; degree of polymerization ; starch ; pasting ; retrogradation ; digestibility ; hyperlipidemia ; resistant starch ; Bifidobacterium pseudolongum ; gut microbes ; synbiotics ; hemp protein isolate ; (−)-epigallocatechin gallate ; covalent binding ; structural changes ; emulsifying properties ; polysaccharide-based materials ; edible packaging ; cellulose ; hemicellulose ; chitosan ; polysaccharide gums ; Holothuria leucospilota ; fermentation behaviors ; antioxidant activity ; zein ; flaxseed gum ; ultrasound ; complex particle ; Pickering emulsion ; soybean residue ; insoluble dietary fiber ; fermentation in vitro ; colon health ; pea ; protein co-precipitates ; protein blends ; surface hydrophobicity ; surimi ; setting ; water migration ; chemical interactions ; purslane polysaccharides ; selenylation ; RAW 264.7 macrophages ; splenocytes ; immune modulation ; type 2 diabetes ; β-glucan ; molecular structure ; anti-diabetic function ; macronutrient absorption ; enzyme inhibitor ; ovomucoid ; superheated steam ; modification ; allergenicity ; mass spectrometry ; acrolein ; IEC-6 cells ; autophagy ; apoptosis ; carboxymethyl chitosan ; frozen surimi ; myofibrillar protein ; denaturation ; gelling properties ; walnut protein isolates ; oxidation ; structural characteristics ; functional properties ; proteomics ; collagen peptide ; B16F10 cells ; melanogenesis ; tyrosinase ; antioxidant ; pea fiber ; industry-scale microfluidizer ; structure ; quinoa protein ; ultrasounic-assisted extraction ; in vitro digestion ; amino acid content ; nuclear magnetic resonance hydrogen spectroscopy ; Chinese yam ; structural characterization ; oxidative stress ; okara ; prebiotic ; γ-irradiation ; anthocyanins ; stable system ; inclusion complex ; hydrogen bonding ; biological activity ; packaging ; preservation ; gelatin ; mulberry leaf polysaccharides ; miscible system ; zeta potential ; rheological properties ; betanin ; gelatinization ; camelina cake polysaccharide ; carrier ; stabilizer ; purple corn cob ; by-product ; anthocyanin bioaccessibility ; tapioca ; hygroscopicity ; BET and GAB models ; particle size characteristics ; storage stability ; pea protein ; moderate enzymatic hydrolysis ; structure properties ; dual protein ; plant protein ; co-precipitation dual protein ; blended dual protein ; fish sausage ; pre-emulsion ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The article collection of this Special Issue reprint covers a wide range of neurorehabilitation modalities, although they only represent a small proportion of the whole scene. We trust that they will assist clinicians in performing evidence-based interventions and illuminate the necessity of multidisciplinary collaboration. Furthermore, they share an important motivational drive, that is, the inspiration to move forward to a new era where medical, basic research, engineering, and high-tech advances can develop more efficacious approaches, combining neuromodulation techniques under sophisticated neuroimaging guidance. These can be widely and remotely applied to all people that need them, organized under a fresh “patient-centric” approach, with home-based and tele-rehabilitation protocols replacing long stays in medical centers.
    Keywords: Covid-19 ; telerehabilitation ; post-stroke rehabilitation ; virtual reality ; stroke ; percutaneous electric nerve stimulation ; transcutaneous electric nerve stimulation ; adult ; urinary bladder ; overactive ; urinary incontinence ; tibial nerve ; multiple sclerosis ; employment ; patient-reported outcome ; MSWDQ-23 ; validation ; rTMS ; dementia ; Alzheimer’s disease ; magnetic stimulation ; non-pharmacological treatments ; refractory temporal seizures ; neurosurgery ; cognitive outcome ; memory ; long-term follow-up ; backward walking ; balance ; cerebral palsy ; mental motor imagery ; neurorehabilitation ; cost–utility ; upper extremity ; EQ-5D ; cognitive exercise therapy ; sensorimotor ; activity of daily living ; Parkinson’s disease ; salivation ; clinical features ; non-motor ; motor ; sialorrhea ; drooling ; oxidative stress ; antioxidant defense ; Oxidative Status Index (OSI) ; hydroperoxides ; rehabilitation ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Polyphenols are natural phytochemicals recognized as one of the largest and most widespread classes of plant constituents occurring throughout the plant kingdom. Over the years, polyphenols have attracted the attention of the scientific community due to their potential health-promoting effects. Owing to their several interesting properties, polyphenols have aroused considerable interest, shedding light on their chemistry, reactivity, biological properties and their beneficial effects on both plants and humans. As a result of these investigations, a huge number of research works have been reported on polyphenols. However, despite the voluminous literature studying polyphenols and their impact on human health, there are still many issues waiting to be explored in order to explain and elucidate the positive effects of polyphenols on human health. This Special Issue was intended to gather up-to-date knowledge related to the cutting-edge research in the broad scientific area of polyphenols, providing an opportunity to show the latest advances in the exploration of polyphenols and their health beneficial effects. The special issue was a great success with more than 50 published manuscripts covering various aspects related to polyphenols and their role in human health. We are confident that this Special Issue will be of great interest to the scientific community, and will contribute to the improvement of knowledge regarding the area of polyphenols, leading to a better understanding of their role in human health.
    Keywords: polyphenolic curcumin ; cisplatin ; combination therapy ; breast cancer ; apoptosis ; gemini surfactant nanoparticles ; Mucuna pruriens seed ; neuroprotective activity ; Parkinson’s disease ; anti-acetylcholinesterase activity ; L-dopa ; Mitrephora sirikitiae ; anti-inflammation ; lignans ; polyphenols ; mRNA expression ; cytokines ; gemini curcumin ; colorectal cancer ; RNA sequencing ; PPI network ; differentially expressed genes ; Ericaceae ; LC–DAD/ESI–MS ; phenolic compounds ; flavonoids ; antioxidant activity ; Artemia salina Leach ; resveratrol ; hexavalent chromium ; 8-hydroxydeoxyguanosine adduct repair ; endogenous antioxidant system ; antigenotoxic ; Opuntia sp. ; prickly pear ; inflammation ; ginseng leaf ; far-infrared irradiation ; ginsenosides ; antioxidants ; health benefits ; polysaccharides ; freeze-drying ; spray-drying ; antidiabetic ; Averrhoa carambola L. ; dihydrochalcone ; flavone glycosides ; obesity ; Oxalidaceae ; type 2 diabetes ; Alchemilla viridiflora Rothm. ; SARS-CoV-2 ; COVID-19 ; spike glycoprotein ; neuropilin-1 ; in vitro ; in silico ; Origanum compactum ; HPLC-PDA-ESI/MS ; antibacterial activity ; bioactive compounds ; nutraceuticals ; phenols ; pomegranate peels ; phytochemical ; wistin ; NADES ; total polyphenolic content ; enzyme inhibition ; functional food ; natural medicine ; Alzheimer cholinesterase inhibitors ; Maqui ; platelets ; phenolic compounds and cardiovascular ; phenolic acids ; sinapic acid ; ACE inhibition ; hypertension ; endothelial dysfunction ; Graminex pollen ; hydroalcoholic extract ; oxidative stress ; gene expression ; TRPV1 ; pterostilbene ; antioxidant ; bioavailability ; cancer ; diabetes ; Nrf2 ; Rosmarinus officinalis ; chemical analysis ; glioblastoma ; rhabdomyosarcoma ; red onion ; phytochemicals ; H9c2 rat cardiomyoblast ; primary human fibroblasts ; blood disorder ; haemoglobin ; natural product ; nutraceutical ; nutritional disease ; lichens ; neuroprotection ; cetrarioid clade ; grape polyphenols ; sarcopenia ; skeletal muscle ; clinical trial ; R. conduplicans ; lichen ; secondary metabolites ; DNA damage ; α-glucosidase inhibition ; adlay ; adlay testa ; antiglycation ; phenolic acid ; grape pomace ; anti-inflammatory ; curcumin ; poly(glycerol sebacate) ; nanoparticles ; drug delivery system ; human cervical cancer ; baicalein ; mangiferin ; quercetin ; diabetes mellitus ; peripheral artery disease ; cardiovascular diseases ; Cyperus esculentus ; tiger nut ; metabolomics ; UHPLC-ESI-QTOF-MS/MS ; foodomics ; scopolamine ; memory impairments ; phenol compounds ; polydatin ; 3-O-β-d-resveratrol-glucopyranoside ; cervical cancer ; lung cancer ; ovarian cancer ; nanosuspension ; antioxidant properties ; LPS-induced inflammation ; NO-scavenging activity ; mountain tea ; Lamiaceae ; iridoids ; phenylethanoids ; ultrasound-assisted extraction ; melittoside ; ajugoside ; verbascoside ; ferulic acid ; apoptosis and cell cycle arrest ; anti-angiogenesis ; anti-metastasis ; synergism ; Cymbopogon schoenanthus ; hyaluronidase ; acetylcholinesterase ; neurodegeneration ; skin ; hair ; human health ; immobilized PTP1B ; drug screening ; cell surface display ; salvianolic acid B ; traditional Chinese medicine ; Salicornia ; extraction technologies ; agro-industrial by-products ; biological activity ; circular economy ; health effects ; re-integration ; waste management ; blood orange peels ; infrared-assisted extraction ; optimization ; Aflatoxin B1 ; Achillea millefolium ; bioaccessibility ; Caco-2 absorption ; in vitro digestion ; sterol regulatory element-binding protein 1 ; human oral squamous cell carcinoma ; autophagy ; epidermal fatty acid-binding protein ; lentil hull ; enzymatic hydrolysis ; microwave-assisted extraction ; oligosaccharides ; Alocasia gigantea ; hepatocellular carcinoma ; histopathology ; UHPLC–DAD–ESI–MS/MS ; Salvianolic acid B ; matrix metalloproteinase 9 ; gelatinase B ; MDA-MB-231 human breast cancer cells ; TIMP-1 ; agri-food wastes ; sustainability ; polyphenols bioavailability ; polyphenols activity ; cosmeceuticals ; nano-delivery ; health ; Lithocarpus litseifolius ; trilobatin ; phloridzin ; phloretin ; metabolic pathway ; bioactivity ; honey ; functional beverage ; characterization ; alcoholic beverage ; fermented beverage ; functional foods ; beneficial effects ; biological treatment ; bioreactors ; water ; aerobic granular sludge ; conventional active ted sludge ; biofilter ; photobioreactor ; membrane bioreactor ; bio-electrochemical systems ; chitosan ; Indian borage ; biotic elicitor ; insect-based foods ; Folin–Ciocalteu method ; phenols and flavonoids ; polyphenols bioactivity ; cereal ; pre-harvest sprouting ; antiradical capacity ; antitumor activity ; bee products ; phenylamides ; multivariate statistical analysis ; Juniperus sabina ; cupressuflavone ; intranasal ; pharmacokinetic ; motor coordination ; oregano ; box–behnken ; phenolics ; HPLC-PDA analysis ; UPLC-Q-TOF MS ; olive pomace ; PBMC ; immune gene expression ; HPLC-DAD ; metabolome ; phenolic bioaccessibility ; propolis ; total phenolic compounds ; antioxidant capacity ; UHPLC-DAD-ESI-MS ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: The present Special Issue will lead you to discover the association between cardiovascular and metabolic diseases, through update reviews and original articles exploring the pathophysiological mechanisms underpinning this association and describing the latest results in term of cardiovascular event prevention. An interesting scientific journey that reflects the recent advances in pharmacological treatments and interventional procedures.
    Keywords: low-density lipoprotein receptor ; apolipoprotein E ; hyperglycemia ; type 2 diabetes ; Western diet ; diabetes mellitus ; GPCRs ; GPR26 ; monocytes ; peripheral blood cells ; metabolomics ; diabetes ; N-Acetyl asparagine ; QTc ; cardiac fibrosis ; scar tissue ; anti-fibrotic therapies ; cardiovascular diseases ; myofibroblasts ; nitric oxide synthase uncoupling ; sapropterin ; diabetic nephropathy ; atrial fibrillation ; hyperthyroidism ; warfarin ; ischemic stroke ; transient ischemic attack ; transplant ; complications ; mortality ; outcome ; glucose metabolism ; body mass index ; metabolic syndrome ; breast arterial calcifications ; cardiovascular risk ; mammograms ; risk assessment ; prevention ; cost effectiveness ; cardiac autonomic neuropathy ; oxidative stress ; inflammation ; endothelium dysfunction ; direct oral anticoagulant ; stroke prevention ; elderly ; frail ; malignancy ; extreme weight ; bioprosthetic valve ; endocannabinoid system ; CB1 cannabinoid receptor ; metabolic disease ; non-alcoholic fatty liver disease ; sodium-glucose cotransporter inhibitors ; metformin ; FibroScan® ; controlled attenuation parameter ; type 2 diabetes mellitus ; heart failure ; hemodynamics ; dapagliflosin ; adropin ; natriuretic peptide ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 40
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The production of food enriched with bioactive compounds, through natural means, represents a concept desired by nutritionists, doctors and consumers. Animal products with high nutritional quality can be designed using innovative feeding strategies. Animals are known to be able to ‘‘bio-convert’’ health-promoting components from their diet into their eggs, milk or meat. The nutritional quality of animal products depends on genetic, physiological and environmental conditions, but also upon their diets. Lately, various feed additives have been shown to increase the nutritional quality of animal-origin food, which in turn promotes a healthy human diet. Some of them have proven effects on productive parameters or on the sensory attributes of animal products, or modify the nutrient composition of products. Nutritional evaluations of animal products and feeds are necessary for establishing the bioconversion yield of nutrients, from feeds to animal-origin food. This Special Issue focuses on, but is not limited to, the development of new feeding formulas thst lead to improved animal production or the enhanced nutritional profiles of conventional or ecological animal products. Studies presenting feed additives that have beneficial effects on the production and quality of animal products, as well as natural feeding solutions that are environmentally friendly, were also welcomed. The proposed Special Issue is addressed to specialists from the domains of animal nutrition, food quality, chemistry and biology.
    Keywords: L. acidophilus ; L. plantarum ; microencapsulated probiotics ; weaning piglets ; performance ; microflora ; piglets’ health ; parsnip fermented juice ; hawthorn extract ; natural nitrite ; natural antioxidant ; lipids stability ; spoilage bacteria ; heme pigment conversion degree ; bioactive compounds ; carcass ; chromium supplementation ; ionophore ; nutrition ; yeast-based blend ; male layer-type chickens ; age ; meat quality ; fatty acids ; ruminants ; tannins ; saponins ; feed additives ; dairy cows ; Clostridium ; Bacillus ; probiotics ; resistance ; blood chemistry ; antioxidants ; detoxification ; health benefits ; Bos indicus ; NutraGen ; stress ; supplementation ; weaned calves ; artificial pigment alternative ; broiler nutrition ; carotenoids ; health ; pigment additives ; vegetal waste ; zearalenone ; piglets ; weaning ; inflammation ; oxidative stress ; signaling pathway ; olive ; atherogenic ; milk ; sheep ; lipids ; small ruminants ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFU Animals and society
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: The lifestyle associated with good quality of food is well known for its widely recognized health benefits, especially when rich in bioactive compounds. Reduced risks of some types of cancer and other diseases have been associated with the adoption of such a diet, as have increased antioxidants, inhibitors of lipid peroxidation, decrease of pro-inflammatory cytokine production, etc. The focus of this Special Issue of Toxins was to gather advances related to the cytotoxicity of natural toxins and the potential for the cytoprotection of natural compounds present in food or plants. In this context, this Special Issue of Toxins comprises eight original contributions. Special attention is given to Fridericia chica (Bignoniaceae) leaves grown in Colombia, extract from Polygonum cuspidatum, Artemisia annua and coffee extracts against mycotoxins´ effects. Studies of mycotoxins in different animal and human cell lines are also presented for zearalenone, beauvericin, α-zearalenol and β-zearalenol, among others.
    Keywords: nano-silicate platelets ; necroptosis ; reactive oxygen species ; endocytosis ; membrane integrity ; Apoptosis ; bovine mammary epithelial cells ; endoplasmic reticulum stress ; polydatin ; zearalenone ; beauvericin ; α-zearalenol ; coffee silverskin ; spent coffee ; SH-SY5Y cells ; mycotoxin ; apoptosis ; endothelial cells ; calcium ; autophagy ; granulosa cells ; PI3K-AKT-mTOR ; MAPK ; chicken ; PAT ; ROS ; oxidative stress ; mitochondrial oxidative phosphorylation ; cytotoxicity ; mycotoxins ; Fridericia chica ; protection ; extracts ; artemisinin ; anticancer effects ; stress granules ; alternative extraction procedures ; osteosarcoma cells ; HeLa cells ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 42
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Inflammation is a complex biological response to injury as a result of different stimuli such as pathogens, damaged cells, or irritants. Inflammatory injuries induce the release of a variety of systemic mediators, cytokines, and chemokines that orchestrate cellular infiltration, consequentially bringing about the resolution of inflammatory responses and the restoration of tissue integrity. However, persistent inflammatory stimuli or the disregulation of the mechanisms of the resolution phase can lead to chronic inflammation and inflammatory-based diseases. Nowadays, commercially approved anti-inflammatory drugs are represented by nonsteroidal anti-inflammatory drugs (NSAID); glucocorticoids (SAID); and, in some cases, immunosuppressant and/or biological drugs. These agents are effective for the relief of the main inflammatory symptoms. However, they induce severe side effects, and most of them are inadequate for chronic use. Starting from these premises, the demand for new, effective, and safe anti-inflammatory drugs has led research in new therapeutic directions. The recent and emerging scientific community slant is oriented towards natural products/compounds that could represent a boon for the discovery of new active molecules and for the development of new drugs and potentially useful therapeutic agents in different inflammatory-related diseases. We hope that it will stimulate the interest of the scientific community involved in studying the effects of natural and synthetic compounds in different fields of interest such as acute and chronic inflammation, inflammatory pain, inflammation-related diseases (e.g., autoimmune diseases), amongst others.
    Keywords: Padina boryana ; alginic acid ; particulate matter ; skin ; inflammation ; chelation ; BELFRIT ; immunity ; mPGES-1 ; natural compounds ; Th17 ; sulforaphane ; osteoclastogenesis ; autophagy ; JNK signaling pathway ; baicalin ; Glaesserella parasuis ; tight junctions ; peritoneum ; piglets ; calceolarioside A ; nociception ; phenylpropanoid glycosides ; Calceolaria ; citropten ; colitis ; T cell activation ; intestinal cell activation ; anti-inflammation ; MAPK ; diabetes mellitus ; infertility ; oxidative stress ; Portulaca oleracea ; Crepis ; Asteraceae ; LC-MS ; NMR ; cichoric acid ; phenolic acid ; biological activity ; mouse paw edema ; antihyperlipidemic ; NLRP3 ; IL-1β ; natural products ; docking ; design ; Allium cepa L. ; quercetin ; bioaccessibility ; design of experiments ; anti-inflammatory activity ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 43
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: Regarding the increasing use of nanomaterials in almost every area of our daily life, toxicological risk assessment is one of the major requirements for their safe handling. Especially at workplaces, inhalation is the major route of exposure and potential toxicity, and effects on the lung need to be considered. Furthermore, neurotoxicity associated with exposure to nanomaterials is a growing field of scientific investigation. However, not every single nanomaterial can be assessed in long-term animal inhalation studies, due to limited resources as well as political and societal efforts to reduce animal experiments according to the 3R principles. Thus, during the last few years, significant efforts have been dedicated to grouping nanomaterials, mainly based on advanced in vitro models. These new approach methodologies (NAMs) include detailed characterization of the respective materials in physiologically relevant media, but also more realistic exposure systems, such as co-cultures, also at the air–liquid interface, combined with comprehensive cellular investigations that provide quite detailed toxicological profiles. Thus, nanoparticles show differences in toxicity depending on their size, surface reactivity, and dissolution kinetics. Adverse cellular effects include inflammation, genotoxicity, oxidative stress, and epigenetic alterations. This Special Issue aims to highlight the recent advances in the mechanisms of nanomaterial toxicity, as well as the approaches for risk assessment, linking nanoparticle characteristics as well as in vitro toxicity to in vivo observations for advanced risk assessment.
    Keywords: nanotoxicology ; titanium dioxide ; synthetic amorphous silica ; agglomerates and aggregates ; realistic exposure in vitro ; nanomaterials ; agglomerates ; air-liquid interface ; pulmonary toxicity ; metal-based nanoparticles and nanowires ; solubility ; intracellular bioavailability ; oxidative reactivity ; comet assay ; FADU assay ; engineered nanomaterials ; DNA strand breaks ; genotoxicity ; ENM interference ; hazard assessment ; database ; lung toxicity ; study quality ; nanoparticles ; gene regulation ; endocytosis ; inflammation ; NR4A1 ; interlaboratory comparison ; minimal information ; quality criteria ; description standards ; graphene ; 2D ; nanoplates ; lung ; inhalation ; toxicity ; in vitro ; Cr2O3 particles ; Cr(VI) release ; cytotoxicity ; gene expression profiles ; DNA damage signaling ; DNA repair proteins ; oxidative stress ; cell death pathways ; NAMs—new approach methodologies ; ALI—air–liquid interface ; BEAS-2B ; A549 ; NM-300K ; DNA damage ; chromosomal damage ; cytokines ; TiO2 NPs ; titanium dental implants ; 3D spheroids ; osteoblasts ; safe-by-design ; hazard testing ; in vitro methods ; SAbyNA ; advanced materials ; carbon nanotubes ; in vitro models ; respiratory tract ; bronchial epithelium ; alveolar epithelium ; ciliary beating frequency ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Membrane proteins are essential for the diverse biological functions of the cells and intercellular communication in living organisms. With the recent developments in the methodologies, the research on membrane proteins has been undergoing a major transformation. In this informative book, the biological and dynamic behaviour of membrane proteins are introduced, discussed, and reviewed by some of the leading researchers in the field. The main objective of this compendium is to present the recent research in the fundamental and advanced concepts and methodologies used for studying membrane proteins. Membrane protein purification and reconstitution, protein–lipid interaction, ion/substrate transport, conformational and functional dynamics, the interaction of infectious agents, cell death, and organelle morphology are among the topics that are covered. This reprint is intended for a broad range of novice and experienced scientists with different levels of experience, from biophysicists and biochemists to microbiologists, cell biologists, and physiologists.
    Keywords: band 3 ; red blood cells ; antimalarial drugs ; molecular docking ; molecular dynamics ; membrane mechanics ; flicker-noise spectroscopy ; neurodegeneration ; amyloid-beta peptides ; pressure wave ; giant unilamellar vesicles ; membrane protein ; lipid bilayer ; membrane mimetic ; potassium channels ; tetraalkylammonium salts ; protein thermal stability ; homo-FRET ; C-type inactivation ; binding affinity ; selectivity filter conformation ; steady-state and time-resolved fluorescence anisotropy ; long-chain fatty acid ; proton transfer ; purine nucleotide ; conductance measurements in model membranes ; uncoupling ; SARS-CoV-2 ; Betacoronavirus ; Coronaviridae ; transmembrane proteins ; pathogenesis ; inflammation ; immunity ; vaccines ; CA3-CA1 synapses ; NMDA ; AMPA ; systems biology ; multiscale modeling ; Schaffer collateral-CA1 synapses ; fatty acid anion transport ; proton transport ; ADP/ATP carrier protein ; mitochondrial transporter ; arachidonic acid ; long-chain fatty acids ; nitric oxide ; ferroptosis ; lipid peroxidation ; lipoxygenase structure ; O2 and NO● binding mechanisms ; 1-stearoyl-2-arachidonoyl phosphatidylethanolamine (1-SA-2-ETE-PE or SAPE) ; lipidomics ; MD simulations ; influenza virus fusion peptides ; peptide-membrane interactions ; membrane fusion ; membrane ; peptidoglycan ; efflux pump assembly ; resistance ; Pseudomonas ; AAA-type protease ; Arabidopsis thaliana ; FtsH metalloprotease ; chloroplast ; embryo lethal ; leaf variegation ; plastid biogenesis ; protein import ; oxidative stress ; lipid–protein interaction ; cryo-electron microscopy ; hydrogen–deuterium exchange mass spectrometry ; native mass spectrometry ; single-molecule Förster resonance energy transfer ; double electron–electron resonance ; angulin-1 ; LSR ; tricellulin ; tricellular tight junction ; paracellular water transport ; tight epithelium ; MDCK C7 cells ; intermediate-tight epithelium ; HT-29/B6 cells ; apoptosis ; mitochondria ; Bcl-2 family ; Bax ; Bid ; protein–protein interaction ; protein oligomerization ; fluorescence ; single particle detection ; tetraspanins ; CD81 ; CD82 ; gangliosides ; single-molecule tracking ; microdomain ; membrane diffusion ; fluorescence microscopy ; integral membrane protein ; membrane lipid ; structure ; function ; oligomeric state ; cryo-EM ; advanced mass spectrometry ; membrane mimetic systems ; HMG-CoA reductase ; HMGR ; HMGR vesicle ; ER-HMGR domain ; mevalonate ; endoplasmic reticulum ; OSER ; high-pressure freezing ; chemical fixation ; Archaerhodopsin-3 ; microfluidics ; cell-free gene expression ; cytochrome b5 reductase ; cytochrome b5 ; superoxide anion radical ; electron transfer ; protein intrinsic dynamics ; odorant receptor ; chemosensory ; membrane traffic ; heterologous expression ; mitochondrial carriers ; uncoupling proteins ; ADP/ATP carrier ; membrane protein structure and function ; regulation and mechanism of proton transport ; membrane protein oligomerization ; ATP synthesis ; biphasic proton transport model ; alternating access mechanism ; reactive oxygen species control ; chloroplast-targeting pathways ; chloroplast outer membrane proteome ; signal anchored protein ; tail anchored protein ; β-barrel protein ; β-signal ; chloroplast transit peptide ; TOC complex ; AKR2 ; OEP80 ; ATP-binding cassette (ABC) transporter ; multidrug and toxic compound extrusion (MATE) transporter ; monosaccharide transporter (MST) ; sucrose transporter (SUT) ; amino acid transporter ; detoxification ; nutrient transport ; stress adaptation ; proton gradient ; cellular pH ; small HSP ; membrane chaperone ; membrane fluidity ; stress response ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography
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  • 45
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Abiotic stress includes not only single adversities, i.e., drought, salt, temperature, and elevated CO2, but also complex stresses, i.e., saline and alkali soil, and karst environment. Abiotic stresses strongly affect many aspects of a plant’s substance and energy metabolism. Meanwhile, abiotic stress not only affects the physiological processes of photosynthesis, water metabolism, and inorganic nutrient absorption, but it also influences the electrophysiology and other physical parameters of plants. Plant physiological information, especially online physiological information, helps us to understand the plant’s adaptive mechanism and take the effective measures to improve the production of horticultural plants. This Special Issue contains a collection of 11 important research works, which deepen the connotation and expand the denotation of plant physiology under abiotic stress. These works will provide a theoretical basis for the production of horticultural crops under single stresses, such as drought and salt stress, or under complex stresses, such as saline and alkali and karst environments. Readers from all over the globe are expected to greatly benefit from this Special Issue collection both in terms of their own work and to improve the productivity of horticultural crops under complex abiotic stresses. In the future, we hope that the field of plant (horticultural crop) physiology under abiotic stresses flourishes in terms of academic research and publications.
    Keywords: genovese ; leaf area ; root length ; nitrogen balance index ; anthocyanin ; epicuticular leaf waxes ; drought stress ; GABA: gamma aminobutyric acid ; metabolism ; pea ; Pisum sativum L. ; seedling growth ; water deficit ; agricultural production ; redox ; photorespiration ; chlorophyll fluorescence ; dose effect ; Annonaceae ; antioxidant enzymes ; carbohydrates ; liriodenine ; photosynthesis ; garlic ; chitosan ; yeast ; antioxidant system ; reactive oxygen species ; citrus ; oxidative stress ; proline ; water potential ; vascular bundle modifications ; electrophysiological signals ; intracellular water metabolism ; bioenergetics ; plant physiological information ; water shortage response ; coastal areas ; ornamental plants ; gas exchange ; chlorophyll a fluorescence ; enzyme activity ; jujube ; saline–alkali stress ; sugar metabolism ; antioxidant enzyme ; RT-qPCR ; salinity ; biomass ; chlorophyll ; woody plants ; tolerance ; electrophysiology ; anatomical structure ; cell elasticity ; water status ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes
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  • 46
    facet.materialart.
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Membrane proteins are essential for the diverse biological functions of the cells and intercellular communication in living organisms. With the recent developments in the methodologies, the research on membrane proteins has been undergoing a major transformation. In this informative book, the biological and dynamic behaviour of membrane proteins are introduced, discussed, and reviewed by some of the leading researchers in the field. The main objective of this compendium is to present the recent research in the fundamental and advanced concepts and methodologies used for studying membrane proteins. Membrane protein purification and reconstitution, protein–lipid interaction, ion/substrate transport, conformational and functional dynamics, the interaction of infectious agents, cell death, and organelle morphology are among the topics that are covered. This reprint is intended for a broad range of novice and experienced scientists with different levels of experience, from biophysicists and biochemists to microbiologists, cell biologists, and physiologists.
    Keywords: band 3 ; red blood cells ; antimalarial drugs ; molecular docking ; molecular dynamics ; membrane mechanics ; flicker-noise spectroscopy ; neurodegeneration ; amyloid-beta peptides ; pressure wave ; giant unilamellar vesicles ; membrane protein ; lipid bilayer ; membrane mimetic ; potassium channels ; tetraalkylammonium salts ; protein thermal stability ; homo-FRET ; C-type inactivation ; binding affinity ; selectivity filter conformation ; steady-state and time-resolved fluorescence anisotropy ; long-chain fatty acid ; proton transfer ; purine nucleotide ; conductance measurements in model membranes ; uncoupling ; SARS-CoV-2 ; Betacoronavirus ; Coronaviridae ; transmembrane proteins ; pathogenesis ; inflammation ; immunity ; vaccines ; CA3-CA1 synapses ; NMDA ; AMPA ; systems biology ; multiscale modeling ; Schaffer collateral-CA1 synapses ; fatty acid anion transport ; proton transport ; ADP/ATP carrier protein ; mitochondrial transporter ; arachidonic acid ; long-chain fatty acids ; nitric oxide ; ferroptosis ; lipid peroxidation ; lipoxygenase structure ; O2 and NO● binding mechanisms ; 1-stearoyl-2-arachidonoyl phosphatidylethanolamine (1-SA-2-ETE-PE or SAPE) ; lipidomics ; MD simulations ; influenza virus fusion peptides ; peptide-membrane interactions ; membrane fusion ; membrane ; peptidoglycan ; efflux pump assembly ; resistance ; Pseudomonas ; AAA-type protease ; Arabidopsis thaliana ; FtsH metalloprotease ; chloroplast ; embryo lethal ; leaf variegation ; plastid biogenesis ; protein import ; oxidative stress ; lipid–protein interaction ; cryo-electron microscopy ; hydrogen–deuterium exchange mass spectrometry ; native mass spectrometry ; single-molecule Förster resonance energy transfer ; double electron–electron resonance ; angulin-1 ; LSR ; tricellulin ; tricellular tight junction ; paracellular water transport ; tight epithelium ; MDCK C7 cells ; intermediate-tight epithelium ; HT-29/B6 cells ; apoptosis ; mitochondria ; Bcl-2 family ; Bax ; Bid ; protein–protein interaction ; protein oligomerization ; fluorescence ; single particle detection ; tetraspanins ; CD81 ; CD82 ; gangliosides ; single-molecule tracking ; microdomain ; membrane diffusion ; fluorescence microscopy ; integral membrane protein ; membrane lipid ; structure ; function ; oligomeric state ; cryo-EM ; advanced mass spectrometry ; membrane mimetic systems ; HMG-CoA reductase ; HMGR ; HMGR vesicle ; ER-HMGR domain ; mevalonate ; endoplasmic reticulum ; OSER ; high-pressure freezing ; chemical fixation ; Archaerhodopsin-3 ; microfluidics ; cell-free gene expression ; cytochrome b5 reductase ; cytochrome b5 ; superoxide anion radical ; electron transfer ; protein intrinsic dynamics ; odorant receptor ; chemosensory ; membrane traffic ; heterologous expression ; mitochondrial carriers ; uncoupling proteins ; ADP/ATP carrier ; membrane protein structure and function ; regulation and mechanism of proton transport ; membrane protein oligomerization ; ATP synthesis ; biphasic proton transport model ; alternating access mechanism ; reactive oxygen species control ; chloroplast-targeting pathways ; chloroplast outer membrane proteome ; signal anchored protein ; tail anchored protein ; β-barrel protein ; β-signal ; chloroplast transit peptide ; TOC complex ; AKR2 ; OEP80 ; ATP-binding cassette (ABC) transporter ; multidrug and toxic compound extrusion (MATE) transporter ; monosaccharide transporter (MST) ; sucrose transporter (SUT) ; amino acid transporter ; detoxification ; nutrient transport ; stress adaptation ; proton gradient ; cellular pH ; small HSP ; membrane chaperone ; membrane fluidity ; stress response ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 47
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Cumulative evidence demonstrates that healthy nutrient intake and regular physical exercise are both powerful lifestyle strategies that modulate lifelong health through their ability to improve body composition, musculoskeletal health, sex steroid hormones, sleep quality, and physical and cognitive performance, as well as to prevent chronic diseases across the lifespan, especially in women. While the benefits of nutrition and physical exercise are commonly studied separately, the integration of nutrition and physical exercise has the potential to produce greater benefits in women than strategies focusing only on one or the other. Studying the specificities of women in response to interventions is of the utmost importance for providing optimal healthcare and aids the design of guidelines that are better suited for women. A better knowledge regarding nutrient intake and physical exercise and their interaction in women is therefore needed. This Special Issue entitled “nutrient intake and physical exercise as modulators of healthy women” will comprise manuscripts that highlight this integrational approach as a potential modulator of lifelong outcomes in women.
    Keywords: soy ; ambulatory blood pressure monitoring ; aerobic exercise ; menopause ; blood pressure variability ; sedentary ; sex difference ; exercise intensity ; ventilation threshold ; fat oxidation ; octanoate ; decanoate ; women ; sex hormones ; menstrual cycle ; exercise performance ; nutritional intake ; macronutrients ; interindividual variability ; physical exercise ; aging ; oxidative stress ; antioxidant ; muscle contraction performance ; diabetes ; sarcopenia ; dietary fiber ; hypertension ; obesity ; metabolomics ; nuclear magnetic resonance ; diet ; nutrition ; dietary habits ; uterine leiomyoma ; endometriosis ; polycystic ovary syndrome ; gynecological malignancies ; normal weight obesity ; high-protein diet ; high protein snack ; body composition ; dieting ; emotional eating ; uncontrolled eating ; rumination ; weight ; restraint theory ; physical activity ; psychological aspects ; body image ; preference ; college women ; body size ; dietary restraint ; dietary behaviors ; diet quality ; online survey ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Explore a decade of groundbreaking research in "10th Anniversary of Cells—Advances in Plant, Algae, and Fungi Cell Biology." This reprint offers a comprehensive journey into the realms of plant, algae, and fungi cell biology. Delve into the world of genomics, cellular defense mechanisms, mycorrhizal fungi, and the physiology of extremophile algae. A celebration of scientific excellence, this reprint is a valuable resource for researchers, educators, and enthusiasts passionate about these fascinating domains. Join us in commemorating a decade of discovery and advancement in cellular biology.
    Keywords: membrane proteins ; overproduction ; production platform ; protein purification ; Saccharomyces cerevisiae ; solute carrier 39 ; SLC39 ; family ; yeast ; zinc ; zinc transporters ; ZIPs ; Agave americana ; crassulacean acid metabolism ; genetic engineering ; Nicotiana sylvestris ; phosphoenolpyruvate carboxylase ; photosynthesis ; drought tolerance ; salt tolerance ; microalgae ; Chlamydomonas reinhardtii ; starch ; supraoptimal temperature ; cell cycle ; pilot-scale production ; DNA methylation ; Fusarium graminearum ; in vitro subcultures ; virulence reduction ; ddRAD-MCSeEd ; virulence genes ; 13C ; 14C ; aldol ; Calvin-Benson cycle ; light respiration ; isotope labeling ; cytokinin ; endocytosis ; cytoskeleton ; actin ; plant immunity ; induced resistance ; Parachlorella kessleri ; supra-optimal temperature ; energy reserves ; growth processes ; reproduction events ; deuterium ; deuterated starch ; deuterated lipid ; soft scale insects ; Ophiocordyceps ; symbiosis ; transovarial transmission ; Verticillium wilt ; Glomus viscosum Nicolson ; arbuscular mycorrhizal fungi ; oxidative stress ; antioxidant systems ; defense ability ; ABI5 ; ABF ; AREB ; abiotic stress response ; abscisic acid ; phytohormone crosstalk ; salinity stress ; chloroplast ; plastid ; osmolytes ; osmotic adjustment ; reactive oxygen species ; herbivory ; membrane potential ; ion channel ; Arthrospira ; haloalkalotolerant cyanobacteria ; metagenomics ; phylogenomics ; fatty acid ; enveloped virus ; Ebola virus ; HIV ; herpes simplex virus ; human cytomegalovirus ; influenza virus ; MERS-CoV ; SARS-CoV-2 ; N-glycosite ; O-glycosite ; high-mannose glycan ; complex N-glycans ; Vicieae man-specific lectin ; T/Tn-specific lectin ; specific interaction ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Plants under natural conditions often face multiple stresses, including drought, salinity, temperature extremes, submergence stress, bacteria, viruses, fungi, insects, etc. These biotic and abiotic stresses negatively influence plant growth and productivity. Various approaches have recently been used to overcome stresses in plants. It is necessary to evaluate and explore how diverse molecular techniques can be applied to different biological studies to improve biotic and abiotic stress tolerance in plants. This will help reduce production losses and increase crop tolerance to various stresses. It is now the time to make a difference by developing plants that can withstand biotic and abiotic stresses.
    Keywords: antioxidants ; drought ; oxidative stress ; pearl millet ; redox implications ; ROS ; chlorophyll fluorescence efficiency ; photosynthetic responses ; enzyme activity ; sugarcane ; smut ; circadian clock ; reactive oxygen species ; Al-induced PCD ; photoperiodism ; peanut ; phylogenetic ; virus-induced gene silencing ; transgenic lines ; physiological and biochemical analysis ; Glycine max L. ; PR proteins ; chitinase ; genome-wide ; plant stresses ; crop residues ; profitability ; soil fertility ; soil biology ; allelopathy ; heat shock protein 20 ; maize ; abiotic stress ; yeast-one-hybrid ; abiotic stresses ; cotton ; hormones ; signaling pathway ; WRKY ; papaya (Carica papaya) ; brassicales ; late embryogenesis abundant protein ; orthogroup ; expression profile ; artificial light ; auxins ; chicory ; callus cells ; inulin ; plant growth regulators ; milk thistle ; secondary metabolites ; ecotypes ; salinity ; growth attributes ; biotic stress ; phenolic compounds ; seaweed ; Dendrobium catenatum ; lipase ; multi-omics ; expression pattern ; gene family ; bio-fertilizer ; ionic homeostasis ; organic amendments ; vermicompost ; cold stress ; PKS5 ; stomatal aperture ; microbiota ; natural farming ; physical factors ; physiological changes ; signal transduction and stressed conditions ; Rhizobium leguminosarum ; PGPR ; Triticum aestivum L. ; cadmium stress ; tolerance ; ascorbate ; glutathione ; malondialdehyde ; chlorophylls ; disease gradient ; disease outbreak ; Puccinia ; wheat stripe rust ; plant epidemic ; dispersal ecology ; alternative plant vitrification solution ; ammonium-free medium ; cytotoxicity ; droplet-vitrification ; endangered species ; liquid overlay ; regrowth medium ; within-plant phenotypic plasticity ; combined stresses ; additive ; antagonistic and synergic effects ; VOCs ; potassium ; soybean ; water logging ; yield ; non-thermal plasma ; plant defense ; glucosinolates ; nitriles ; RNA sequencing ; Arabidopsis thaliana ; Bt toxins ; Cry1Ah1 transgenic poplar ; ecology ; environment ; rhizosphere ; candidate genes ; drought tolerance ; crop improvement ; climate change ; adaptation ; Chenopodium quinoa Willd. ; genotypes ; Sahara ; Algeria ; chitosan ; pathogen ; sustainable ; plant protection ; tomato ; melatonin ; photosynthesis ; climate changes ; antioxidant system ; Malus seedlings ; NaCl treatments ; membrane damage ; osmotic regulation ; archives ; botanical collection ; Greece ; landscape ; pre-rebellion period ; wheat ; priming ; Aspergillus niger ; qRT-PCR ; wilting ; TLP ; β-1,3-glucanase ; biostimulants ; biofertilizers ; soil microorganisms ; phytostimulator ; jewel sweet potato ; shoot tip ; axillary bud ; different MS salts concentration ; micropropagation ; plant performance ; C4 species ; heterozygosity ; transient soil salinity ; soil layers ; desertification ; arid regoins ; total flavonoid ; phenolics ; antioxidant activity ; centella ; Na+ content ; molecular markers ; MAS ; oilseeds ; SSRs ; molecular breeding ; dehydration-responsive element binding (DREB) transcription factors ; gene expression ; mosses ; stress tolerance ; common centaury ; salinity stress ; antioxidative protection ; sodium nitroprusside ; proteomic analysis ; drought stress ; sorghum ; RNS ; RSS ; signaling ; post-translational modification ; microorganisms ; stressful conditions ; sustainability ; nutrition ; Brassicaceae ; Cicer arietinum L. ; chlorophyll a fluorescence transient ; physiological and biochemical traits ; high temperature ; chocolate spot disease ; Botrytis fabae ; faba bean ; antioxidant enzymes ; protein banding and anatomy ; actinobacteria ; Streptomyces tuirus ; chilli fruit rot ; Colletotrichum scovillei ; Colletotrichum truncatum ; Fusarium oxysporum ; liquid bio-formulation ; corn smut ; fungus infection ; MDA ; proline ; quality ; halophytes ; Tripolium pannonicum ; hydrogen peroxide ; cell wall extensibility ; cell wall polysaccharide ; coleoptile ; growth inhibition ; lead (Pb) ; rice ; Bactrocera oleae ; spinosad ; kaolin ; organic oliviculture ; chlorophyll fluorescence ; leaf gas exchange ; physiological traits ; BAG (Bcl-2-associated anthanogene) family proteins ; molecular chaperone ; metabolomics ; metabolic responses ; metabolites variation ; surveillance ; Candidatus Liberibacter asiaticus ; comprehensive control ; distribution ; screen house ; Copper hyperaccumulation ; stress mitigation ; EDTA and IAA ; sunflower ; Fusarium wilt ; conventional breeding ; molecular makers ; QTLs ; genomics ; transcriptomics ; metabolomics and proteomics ; bread wheat ; AMF ; zinc ; growth parameters ; osmolyte ; osmoprotector ; ionic attributes ; PGPBs ; growth-promoting fungi ; crop productivity ; plant tolerance ; arbuscular mycorrhizal fungi ; aerobic rice ; soil enzymes ; phosphorus utilization ; P-deficient ; plant growth promotion ; chickpea ; selection indices ; drought tolerant genotypes ; abiotic and biotic stress ; CRISPR ; mega nucleases ; TALEN ; ZFN ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Consumers and stakeholders are increasingly demanding that the meat industry guarantees high-quality meat products with stable and acceptable sensory and safety properties. To do this, it is necessary to understand the mechanisms that underlie the conversion of muscle into meat, as well as the impact of pre- and post-harvest procedures on the final quality and safety of meat products. Over the last two decades, sophisticated OMICs technologies—genomics, transcriptomics, proteomics, peptidomics, metabolomics and lipidomics, also known as foodomics—have been powerful approaches that extended the scope of traditional methods and have established impressive possibilities of addressing meat quality issues. Foodomics were further used to elucidate the biological basis/mechanisms of phenotypic variation in the technological and sensory quality traits of meat from different species. Overall, these techniques aimed to comprehensively study the dynamic link(s) between the genome and the quality traits of the meat that we eat compared to traditional methods, hence improving both the accuracy and sensitivity thanks to the large quantities of data that can be generated. This Special Issue focused on the cutting-edge research applications of OMICs tools to characterize or manage the quality of muscle foods. The research papers applied transcriptomics, targeted and untargeted proteomics, metabolomics, and genomics, among others, to evaluate meat quality, determine the molecular profiles of meat and meat products, discover and/or evaluate biomarkers of meat quality traits, and to characterize the safety, adulteration, and authenticity of meat and meat products.
    Keywords: sea bream ; fish ; spoilage ; metabolomics ; multivariate analysis ; biomarkers ; meat tenderness ; fat ; proteomics ; proteins ; enzymes ; quantification ; biological pathways ; chemometrics ; wooden breast ; myopathy ; feed efficiency ; upstream regulator analysis ; foodomics ; beef tenderness ; bovine biomarkers ; muscle ; proteome ; liquid chromatography-tandem mass spectrometry (LC-MS/MS) ; septuple PCR ; adulteration ; meat species ; mitochondrial genes ; multiplex PCR ; cellular compartments ; protein extractability ; sarcoplasmic proteins ; myofibrillar proteins ; meat quality biomarkers ; DFD meat ; oxidative stress ; certified reference material ; digital PCR ; duck interleukin 2 ; mitochondrial gene ; meat adulteration ; ovine ; color stability ; enzyme ; bioinformatics ; intensive management ; extensive management ; mixing unfamiliar animals ; pre-slaughter stress ; protein biomarkers ; sheep ; tenderness ; novel isoforms ; alternative splicing ; CTCF ; Iso-seq ; ChIP-seq ; DNA metabarcoding ; animal species ; species identification ; NGS ; food adulteration ; validation ; interlaboratory ring trial ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The Special Issue provides twelve contributions, of which three original articles, seven narrative reviews, one systematic review, and one meta-analysis that, altogether, offer a multifaceted and multidisciplinary overview that allows to draw a picture as intriguing and fascinating as possible on the benefits of curcumin and also to suggest potential fields of activities still to be explored. Among the biological activities exerted by curcumin, the anti-oxidative and anti-inflammatory properties reported in many studies make it a potential effective tool in preventing and counteracting chronic-degenerative diseases, very often associated with obesity and aging, such as cardiovascular diseases, T2D, metabolic dysfunctions, neurodegenerative diseases, and cancer, all of them characterized by the presence of oxidative and inflammatory processes. The main concerns that arise from the evaluation of the preventive/therapeutic effects of curcumin are, first of all, the still small number of randomized placebo-control studies available; in addition, small sample sizes have generally been considered, and different protocols and different formulations as well as different routes of administration of curcumin have been used. Thus, it is quite difficult to compare the results and to provide a standard protocol for the use of this promising natural compound. For these reasons, and taking in account the growing use of curcumin by the general population, further investigations to confirm and expand current findings are mandatory and research on curcumin and its effects on human health have to be fostered and promoted.
    Keywords: curcumin ; glycogen synthase kinase-3 ; insulin resistance ; Islet amyloid polypeptide ; type 2 diabetes mellitus ; inflammatory bowel disease ; proctocolitis ; turmeric ; complementary therapies ; phytotherapy ; gut microbiota ; polyphenols ; health ; fish oil ; mood ; subjective memory complaints ; APOE4 ; randomized controlled trial ; pregnancy ; pregnancy complications ; postpartum depression ; fetal development ; preterm birth ; adverse effects ; bioactive nutraceutical ; nutriepigenomics ; DNA methylation ; breast cancer ; chemoprevention ; curcuma ; type 2 diabetes ; dyslipidemia ; meta-analysis ; randomized control trial ; glioblastoma ; anticancer ; molecular signaling mechanism ; obesity ; inflammation ; adipose tissue ; aging ; brain ; cognition ; bioavailability ; oxidative stress ; antioxidant ; microbiota ; micelles ; apoptosis ; comet assay ; genotoxicity ; senolytics ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Dive into the fascinating world of photosynthesis through the latest publications. This comprehensive work delves deep into the intricate regulatory mechanisms that underpin the vital process of photosynthesis. From the molecular reactions at the core to the overarching responses of entire plants, explore the diverse facets of this fundamental phenomenon. Discover how plants adeptly adapt to an ever-changing and often challenging environment. Gain valuable insights with real-world applications, spanning agriculture, forestry, and biotechnology. Whether you're a scientist, educator, or enthusiast, this reprint promises to unravel the mysteries of life's essential processes. Join us in this exploration of photosynthesis as we bridge the gap between scientific inquiry and practical knowledge, ensuring a sustainable future for both natural ecosystems and cultivated environments.
    Keywords: abiotic stressors ; environmental stress ; growth ; light intensity ; photosynthetic pigments ; picocyanobacteria ; plant physiology ; Alternaria brassicicola ; chlorophyll a fluorescence ; chloroplast ultrastructure ; defense response ; microarray ; photosynthesis ; susceptibility ; chlorophyll fluorescence ; extremely low frequency magnetic field ; Schumann resonance frequencies ; photosynthetic light reactions ; non-photochemical quenching ; quantum yield of photosystem II ; wheat ; pea ; endophytes ; culture filtrate ; exogenously hormone ; Phaseolus vulgaris ; antioxidant enzymes ; antioxidants ; carotenoids ; photochemical efficiency ; protein ; tocopherol ; xanthophyll cycle ; zeaxanthin ; root ; rhizosphere ; rhizobacteria ; root morphology ; abiotic stresses ; phase-sensitive imaging ; magnetopriming ; UV exclusion ; leaf venation ; leaf hydraulics ; high light ; thylakoid membrane ; microdomains ; photoprotection ; Synechocystis ; photoinhibition ; photosystems ; seed priming ; nanotechnology ; germination ; seed resistance ; sustainability ; cold plasma technology ; machine learning ; proton gradient regulation 5 (PGR5) ; PGR5-like photosynthetic phenotype 1 (PGRL1) ; photosynthetic electron transport ; PSI photoinhibition ; oxidation of P700 ; oxidative stress ; combined effect ; Pisum sativum L. ; nanoparticles ; cerium oxide ; zinc oxide ; metal uptake ; hydroponic culture ; photomorphogenesis ; Pinus sylvestris ; light of various spectral composition ; gene expression ; pigment content ; lipid droplets ; microalgae ; Raman spectroscopy ; Surface-enhanced Raman Spectroscopy ; cyanobacteria ; heavy metals ; nitrogenase ; heterocyst ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: With the aging of the population, the incidence rate and number of elderly nervous system diseases have increased sharply. This event has brought huge problems to society. Despite significant efforts being made to explore new treatment options and drugs, the results have been limited. The reason may be due to people's incomplete understanding of the pathogenesis of these age-related diseases. Iron is the most abundant trace element in the human body and is essential for normal life activities. Previous studies have shown that brain iron levels increase with age. The abnormal increase in brain iron levels is closely related to age-related neurological diseases. The disruption of the redox balance may be an important mechanism for the occurrence of neurological diseases caused by brain iron abnormalities. This Special Issue mainly highlights and discusses the latest research progress related to the regulation of brain iron metabolism, redox balance, and the pathogenesis of neurological diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), cerebral ischemia, cancer and maintenance of cellular stemness. The molecular mechanisms of iron-misregulation-induced redox imbalance in disease pathogenesis were analyzed. On this basis, further discussions were conducted on potential therapeutic targets for regulating iron metabolism to achieve effective intervention in elderly neurological diseases.
    Keywords: glioma ; ferroptosis ; lipid peroxidation ; molecular mechanisms ; treatment ; CHIR99021 ; glycogen synthesis kinase 3 ; classical Wnt signaling pathway ; ferritin ; Neuro-2a ; cell stemness ; MitoQ ; PMMP ; autophagy ; radioprotection ; energy phenotype ; coenzyme Q10 ; tissue concentrations ; therapeutics ; Alzheimer’s disease ; dementia ; vascular dementia ; Lewy body dementia ; IRP2 ; Hif2 inhibition ; Fe-S clusters ; ferritinophagy ; microcytic anemia ; iron homeostasis ; iron dysregulation ; inflammation ; infection ; cancer ; iron chelation ; glucose metabolism ; NLRP3 inflammasome ; insulin resistance ; oxidative stress ; CY-09 ; OTUD3 ; ER stress ; IRE1α ; XBP1s ; Fortilin ; intracellular iron homeostasis ; neuroinflammation ; neurodegenerative diseases ; Nrf2 ; NF-κB ; 4-HNE ; Parkinson’s disease ; stroke ; neurodevelopment ; iron chelator ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: Overcoming biological barriers is a significant challenge in drug development, and recent advancements in drug delivery systems and technologies offer promising solutions. This Special Issue highlights the innovative approaches and techniques being used to improve drug permeability and absorption, as well as their potential impact on a wide range of therapeutic goals. These advancements being made in drug delivery and permeability offer exciting possibilities to improve patient outcomes.
    Keywords: brain tumor ; glioma ; drug delivery ; injection ; intra-arterial ; chemotherapy ; targeted therapy ; immunotherapy ; nanoparticles ; treatment ; blood–brain barrier modulation ; tight junction ; active efflux ; transcytosis ; oligonucleotide ; lipid conjugates ; LNP ; delivery ; cholesterol ; fatty acid ; tocopherol ; squalene ; intranasal ; nose-to-brain ; CNS ; nanocarriers ; niosomes ; catechin ; dermal delivery ; antioxidant activity ; oxidative stress ; skin barrier ; penetration ; cellular uptake ; focused ultrasound ; blood–brain barrier opening ; therapeutic agent delivery ; ultrasound parameters ; ultrasound safety ; review ; lung metastasis ; targeting ; colorectal cancer ; liposome ; immunogenicity ; CRISPR-Cas9 ; blood-brain barrier ; intestinal epithelial barrier ; drug permeability ; wound healing ; natural products ; advanced delivery ; traditional medicine ; alternative medicine ; camptothecin ; metastasis ; mitochondria ; 2-(dimethylamino) ethyl methacrylate ; dissolution ; absorption ; inhalation ; dry powders ; fine particle dose ; anxiety ; blood–brain barrier ; brain bioavailability ; depression ; drug molecule functionalization ; nanoemulsions ; nanosystems ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: With the advancements in the medical and scientific fields, the global community has acquired a comprehensive understanding about brain insults and pathologies. In addition, new findings and discoveries are being made globally every day, which keep our curiosity high and drive a knowledge gain. Any brain insult or pathology is multifactorial, including a cascade of inflammation, necrotic, and apoptotic pathways; can be influenced by genetic or environmental factors; and may lead to chronic neurodegeneration or disabilities. This Special Issue, entitled “Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach”, has addressed various important aspects of brain injury and neurodegeneration, such as TBI, cerebral hypoxia, epilepsy, AD, and SARS-CoV-2-mediated brain damage. It received appreciable global response, and published 18 peer-reviewed articles, including 10 research articles and 8 reviews. Briefly, it explores the recent coronavirus infection-mediated cerebral damage; discusses the mechanism of TBI, ischemia, hypoxia, and epilepsy; talks about neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and CONDCA; and, finally, reviews the translational values of phytochemicals in brain pathologies. In conclusion, this Special Issue provides a unique review on brain injury and neurodegeneration, and will be a good tool in enhancing knowledge in terms of brain disease-related pathology, mechanisms, and translational approach.
    Keywords: neurodegenerative diseases ; phytochemicals ; natural products ; neuroprotection ; neurotrauma ; neuroinflammation ; excitotoxicity ; oxidative stress ; apoptosis ; edema ; brain injury ; therapeutic strategies ; 18F-FDG PET ; anosmia ; COVID-19 ; SARS-CoV-2 ; olfactory dysfunction ; anti-convulsants ; anti-epileptic drugs ; drug targets ; epileptogenesis ; non-communicable disease ; seizures ; transcriptional modifications ; pseudo-resistance ; ischemia ; FABP3 ; FABP5 ; FABP7 ; mPGES-1 ; PGE2 ; treadmill exercise ; Parkinson’s disease ; neural mitochondrial functions ; amyloid beta ; Alzheimer’s disease ; inflammation ; gene regulation ; organelle dysfunction ; AGTPBP1 ; CCP1 ; CONDCA ; neurodegeneration ; NNA1 ; pcd ; microglia ; chronic alcoholism ; HHV-6 ; Substantia Nigra ; ischemic stroke ; epigenetics ; histone deacetylase ; histone deacetylase inhibitor ; mechanical stimulations ; traumatic brain injury (TBI) ; stretching ; neurons ; GSK-3β ; p-Tau ; extracellular matrix ; icariin ; icaritin ; middle cerebral artery occlusion ; traumatic brain injury ; blunt-force TBI ; post-traumatic seizures ; zebrafish ; sonic hedgehog signaling ; purmorphamine ; mild traumatic brain injury ; microRNA ; exomiRNA ; exosome ; TBI ; tRNA ; miRNA ; isomiR ; RNAseq ; moderate traumatic brain injury ; reactive oxygen species ; cognitive impairment ; mitochondria ; hypoxia ; neuraxis ; hypoxic-ischemic injuries ; neural ischemia ; neural tissue hypoxic injuries ; neuro-recovery ; neurorehabilitation ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue provides an update on the state of the art and current trends in polymeric drug delivery systems specifically designed for improving drug bioavailability. The multiple contributions received further strengthen the role of polymers in modern drug delivery and targeting, illustrating the different approaches possible and unveiling what the future may bring.
    Keywords: Histoplasma capsulatum ; PLGA ; Itraconazole ; macrophage ; functionalized nanoparticle ; F4/80 receptor ; rutin ; nanocrystals ; anti-inflammatory ; hydroxypropyl beta-cyclodextrin ; nanoparticles ; budesonide ; chitosan ; colon delivery ; eudragit ; pellets ; ferrisilicate ; PEG ; insulin ; encapsulation ; diabetic mellitus ; polypeptides ; drug delivery ; doxorubicin ; cancer ; topology of poly-l-cystein ; antimicrobial ; antifouling ; pH sensitivity ; zwitterionic polymers ; gamma radiation ; copolyester ; SPION ; cysteine ; bioconjugation ; and enzymatic release ; polymeric nanoparticles ; drug delivery and targeting ; ocular posterior segment ; oxidative stress ; retinal degeneration ; nerve growth factor ; peanut agglutinin ; zebrafish ; molecular dynamics simulation ; interaction energy ; hydrogen bonding ; solid dispersion ; hot melt extrusion ; amorphous formulation ; tacrolimus ; sucrose acetate isobutyrate ; amorphous solid dispersion ; dissolution ; stability ; pharmacokinetics ; phytomedicine ; nanosponges ; lactoferrin ; bioavailability ; MDA-MB-231 cells ; caspase-3 ; cyclin-D1 ; dendrimers ; Janus nanoparticles ; biocompatibility ; nanoformulation ; pharmaceuticals ; 3D printing ; hybrid scaffold ; polycaprolactone ; vancomycin ; mesenchymal stem cells ; tissue engineering ; drug delivery systems (DDSs) ; osteomyelitis ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: Parasitic infections pose a significant public health challenge, particularly in developing countries, and can lead to long-term illness, disability, and even death. This reprint focuses on parasitic diseases and how parasites respond to the oxidative and nitrosative stress generated by the host's immune system. The articles in this Special Issue cover various aspects of this topic, including the localization of parasites within the host, the impact of nutrition and drugs, and the role of the host's immune defense cells in the parasitic response to oxidative and nitrosative stress. Understanding the mechanisms underlying parasitic diseases is crucial for developing innovative treatments that can target parasites' defense against oxidative stress. This Special Issue serves as a valuable resource for researchers, students, and physicians interested in parasitic infections.
    Keywords: Entamoeba histolytica ; neutrophil extracellular traps (NETs) ; neutrophils ; reactive oxygen species (ROS) ; myeloperoxidase ; auranofin ; drug resistance ; transcriptomics ; redoxomics ; thioredoxin reductase ; chronic Chagas disease ; Trypanosoma cruzi ; antioxidant ; immunomodulation ; immunohistochemistry ; essential oils ; Lippia alba ; limonene ; caryophyllene oxide ; ROS ; antimalarials ; Plasmodium falciparum ; malaria and oxidative stress ; Leishmania braziliensis ; nitric oxide resistance ; American Tegumentary Leishmaniasis (ATL) ; nitrosative stress ; reactive oxygen species ; reactive nitrogen species ; quantitative proteomics ; FASP ; mass spectrometry ; glycolysis ; glutathione metabolism ; Lactobacillus acidophilus ; probiotic ; cysteine proteases ; platyhelminthes ; Cestoda ; oxygen tension ; anaerobic metabolism ; tegument ; mitochondria ; ticks ; mosquitoes ; oxidative stress ; microbiome ; acaricide ; insecticide resistance ; antioxidants ; excretory–secretory products ; helminth ; immune defence ; oxidative burst ; ruminants ; trematode ; parasite ; worm ; trypanosomatids ; growth and differentiation ; parasite oxidative stress ; mitochondrial function ; ATP synthesis ; parasite lipid content ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine::MBNS Epidemiology & medical statistics
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The prevalence of dietary supplement is increased in the world. The primary purpose of dietary supplements is the provide nutrients, such as vitamin and mineral, to maintain health. However, the functional ingredients in food, especially polyphenols, have attracted attention in recent decades, and these ingredients have beneficial effects on human health. On the other hand, a lot of ingredients with poor evidence as to their effects have also been marketed as dietary supplements, and adverse events associated with dietary supplement use have been reported. It is important to choose dietary supplements whose efficacy and safety for our health have been studied.
    Keywords: tinnitus ; antioxidant supplementation ; oxidative stress ; a-lipoic acid ; multi-vitamin supplement ; dietary supplements ; fish protein ; marine protein ; hydroxybutyrate ; TMAO ; biomarkers ; test–retest ; nutritional supplement ; vitamin ; mineral ; herbal ; natural ; botanical ; nutraceutical ; Euglena gracilis EOD-1 ; β-glucan ; paramylon ; fatigue ; selective attention ; antioxidant ; B-vitamins supplement ; vitamin B6 ; ageing ; B-vitamin bioavailability ; ultra-high performance liquid chromatography coupled with mass spectrometry ; excretion ; alternative medicine ; public health ; Internet ; asymptomatic hyperuricemia ; DKB114 ; Chrysanthemum indicum Linn ; Cinnamomum cassia ; clinical trial ; uric acid ; isoflavones ; flavonoids ; phytoestrogens ; soy ; bone health ; cardiovascular risk ; cancer ; menopausal symptoms ; sage ; Salvia officinalis ; Salvia lavandulaefolia ; polyphenols ; cognition ; Cosmos caudatus ; cognitive function ; mood ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC4 Cultural studies: food and society
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Mycotoxins are a diverse group of chemicals that present wide toxicological responses in animals and humans. Their ingestion causes toxic effects that go from acute toxicity to long-term or chronic health disorders. Some mycotoxins have caused outbreaks of human toxicoses, and at least one mycotoxin, aflatoxin B1, is an assumed human hepatocarcinogen. As part of a comprehensive effort to curtail the adverse health effects posed by mycotoxins, substantial research has been conducted to determine the mechanism of action of mycotoxins. Although much information has been obtained regarding the action of several mycotoxins, future research topics should continue to address several areas of critical concern.In vitro studies in different cell lines could detail and explain many of these mechanisms, while in vivo can give a real scenario in the development of a toxic effect. This Special Issue of Toxins collected the most recent reports on the mechanism of action of mycotoxins on single or combined mycotoxins studied in vivo or in vitro, the identification of known and unknown mycotoxins metabolites and other metabolites in different cell lines and animals or matrices (including organs, urine, or blood), and the development of analytical skills to study these mechanisms. A total of eleven papers, eight research papers and three review articles, are included in this reprint.
    Keywords: claudins ; mycotoxins ; intestinal barrier ; tight junctions ; food toxins ; infancy/childhood nutrition ; quality control ; bioaccessibility ; chromatography ; aflatoxin B1 ; bovine ; liver ; RNA-seq ; oxidative stress ; inflammatory response ; toll-like receptor 2 ; zearalenone ; zearalanone ; chicken ; lamb ; pig ; intestinal porcine jejunal epithelial cells ; Keap1-Nrf2 signaling pathway ; glucose nutrient absorption ; fumonisin B1 ; nanobody ; phage-display technology ; detoxification ; efficacy test ; fumonisin ; sphingolipid ; ceramide ; sphingomyelin ; muscle ; heart ; T-2 ; metabolites ; glutathione ; antioxidant enzymes ; mycotoxin ; aflatoxin ; toxicity ; metabolism ; swine ; decontamination ; ROS ; cytotoxicity ; plant extracts ; insulin resistance ; kidney ; metabolic flexibility ; patulin ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Due to global climate change, environmental issues have become more conscious. Seaweeds play a major role in blue carbon, which fixes carbon to the ocean by taking in carbon dioxide through photosynthesis and producing polysaccharides. In addition to environmental problems, marine polysaccharides have various modifying groups and have been found to have different functionality from land plants. Marine polysaccharides have been used in foods and medicines. Recently, novel biocatalysis of polysaccharide-relating enzymes has been discovered. As a result, the functionality of oligosaccharides from marine polysaccharides has been clarified, e.g., health functionality such as anti-cancer, anti-inflammatory effect, intestinal regulation and antioxidant activity. This Special Issue aims to accumulate the knowledge of preparation, function, structure, and application of bioactive oligosaccharides and polysaccharides-relating enzymes from marine organisms. This Special Issue aimed to contribute to the achievement of multiple goals of Sustainable Development Goals (SDGs) (No. 2, 3, 12, 14), and we invited scientists to submit their latest research findings in this field. Comprehensive review papers are also welcomed.
    Keywords: chitinases ; crystalline chitin ; chitooligosaccharides ; N,N′-diacetylchitobiose ; Pseudoalteromonas ; Ulva ; polysaccharide ; oligosaccharide ; structure ; preparation ; activity ; glucanase ; Vibrio ; carbohydrate-binding domain ; glycoside hydrolase family 17 ; keto-deoxy-sugar ; 2-keto-3-deoxy sugar acid ; 2-keto-3-deoxy-l-galactonate ; agarose ; red algae ; 3,6-anhydro-l-galactose ; Codium fragile ; sulfated polysaccharides ; anti-inflammatory activity ; RAW 264.7 cells ; zebrafish ; alginate lyase ; biochemical characterization ; endo/exolytic ; psychrophilic ; cold-tolerant ; fucoidan lyase ; polysaccharides ; crystal structure ; catalytic mechanism ; endo-type ; alkaliphilic ; polyM-preferred ; cold-adaption ; high degree of polymerization ; chitosan oligosaccharide ; N-acetylated chitosan oligosaccharide ; ARPE-19 ; oxidative stress ; Nrf2 ; cancer ; migration ; adhesion ; fucoidans ; human colorectal cancer ; Ecklonia radiata ; Ecklonia maxima ; Sargassum elegans ; monkeypox virus ; protein A29 ; protein A35 ; heparin ; sea cucumbers ; marine sulfated glycans ; surface plasmon resonance ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Due to increasing concern about the use of pesticides and its potential side effects, this book considers the development and application of alternative, environmental-friendly, plant protection methods for the control of weeds, disease, and pests (predators, parasitoids, competitors, plant-plant interactions, microelements, biopesticides). Some of the main advantages of the measures presented in papers are the absence of toxicity to humans and vertebrates, beneficial organisms, and the environment, as well as the absence of pest resistance. In order to provide sustainable and eco-friendly food production, those are important subjects, both in conventional, organic and integrated agricultural farming. Through reviews and original research articles, this reprint covers all aspects of alternative measures in plant protection.
    Keywords: biopesticides ; agriculture ; food supply ; microorganisms ; antifungal ; Botryosphaeriaceae ; chitosan ; GTDs ; madder ; stevioside ; Vitis vinifera ; biocontrol ; Heterorhabditis ; pest and pathogen management ; Photorhabdus ; marketing ; fungi ; Fusarium ; selenium ; micronutrient ; inhibition ; bioactivity ; biologically active compounds ; fungistatic effects ; quercetin ; red alga ; rosmarinic acid ; basal stem rot (BSR) ; phenolic compounds ; lignin ; cellulose ; hemicellulose ; silica body ; crystalline cellulose ; biodegradation ; nematode management ; biological control ; mechanisms ; host plant resistance ; synthetic nematicide ; botanicals ; optimizing strategies ; allelopathy ; oxidative stress ; maize ; soybean ; sunflower ; entomopathogenic fungi ; Tenebrio molitor ; virulence ; pathogenicity ; growth stimulation ; plant–microbe–pest interactions ; rhizosphere competence ; gallic acid ; catechin ; epicatechin ; fungal diseases ; grape berry ; hybrids ; Penicillium ; Botrytis ; Colletotrichum ; Alternaria ; Monilinia ; post-harvest diseases ; Tetranychus urticae ; Euseius stipulatus ; Typhlodromus sp. ; Phytoseiulus persimilis ; citrus orchard ; monitoring ; predators ; pest ; treatments ; aphid ; conservation biocontrol ; parasitoid ; Aphidius colemani ; floral resource plant ; field margin ; Erysiphe alphitoides ; the shoot-biomass amount ; Compu Eye, Leaf & Symptom Area ; antifungal endophytes ; secondary metabolites ; volatile compounds ; anti-oomycete ; Phytophthora infestans ; sporangia germination ; Solanum lycopersicum ; integrated disease management ; plant extracts ; defense inducers ; incidence ; AUDPC ; germination ; biopesticide ; plant–nematode interactions ; nematode effectors and control ; plant resistance ; amino acids ; biostimulant ; glutathione ; herbicide ; safener ; organic waste ; formulation ; improvement ; antifungal activity ; marine ; saline ; wetland ; post-harvest ; antifungal effect ; chloroxylenol ; phenic ; phenol ; Sclerotium rolfsii ; tomato plants ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Spinal cord injury (SCI) leads to paralysis, sensory, and autonomic nervous system dysfunctions. However, the pathophysiology of SCI is complex, and not limited to the nervous system. Indeed, several other organs and tissue are also affected by the injury, directly or not, acutely or chronically, which induces numerous health complications. Although a lot of research has been performed to repair motor and sensory functions, SCI-induced health issues are less studied, although they represent a major concern among patients. There is a gap of knowledge in pre-clinical models studying these SCI-induced health complications that limits translational applications in humans. This reprint describes several aspects of the pathophysiology of spinal cord injuries. This includes, but is not limited to, the impact of SCI on cardiovascular and respiratory functions, bladder and bowel function, autonomic dysreflexia, liver pathology, metabolic syndrome, bones and muscles loss, and cognitive functions.
    Keywords: micturition ; external urethral sphincter ; spinal cord injury ; serotonin ; electromyogram ; fecal microbiota transplant ; inflammation ; anxiety ; rehabilitation ; autonomic dysreflexia ; immune dysfunction ; SCI-IDS ; primary afferents ; nociceptor ; reach-to-grasp ; forelimb function ; upper extremity function ; cardiovascular ; contusion ; neuroplasticity ; osteopenia ; bone loss ; recovery of function ; monoamines ; GABA ; neuromodulation ; pain ; spasticity ; ionic plasticity ; repetitive transcranial magnetic stimulation ; phrenic motor network ; motoneuron excitability ; diaphragm muscle ; spinal cord injury severity ; cardiometabolic disease ; liver and cardiac dysfunctions ; fibrosis ; pathophysiology ; oxidative stress ; contusion model ; respiratory function ; diaphragmatic activity ; phrenic motoneurons ; neuroinflammation ; cytokines ; tumor necrosis factor ; immune cells ; microglia ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Plants produce a wide range of phytochemicals, known as non-nutrition compounds, to confirm their identity, and they are used for the production of natural pharmaceuticals, cosmetics, and functional food, among other things, due to their pro-health properties. The use of modern chromatographic techniques allows for accurate quantitative and qualitative identification of the above-mentioned phytochemicals and their natural products. Liquid chromatography is one of the most efficient and robust specific techniques due to the merits of convenience and strong separation ability, as well as a wide range of material applications for identification. Liquid chromatography is widely used to analyze plants, nutraceuticals, pharmaceuticals, and cosmetics and in natural product quality control or quantitative determination of bioactive compounds. The most commonly used for identifying different plant materials and pharmaceuticals are ultra- and high-performance liquid chromatography with UV-VIS, fluorescence, and diode array, which is equipped with mass spectrometry or tandem mass spectrometry detection methods. Therefore, for this Special Issue, we published studies concerning the latest scientific news, insights, and advances in the field of innovation of liquid chromatography for the analysis of bioactive compounds for pharmaceuticals, cosmetics, and functional food interests.
    Keywords: antibiotics ; food safety ; oral fluid ; pigs ; UHPLC-MS/MS ; dietary supplement ; food supplement analysis ; LC-MS/MS ; release test ; quality control ; food composition ; pentacyclic triterpenoids ; plant feedstock ; supercritical fluid chromatography ; tandem mass spectrometry ; bioactive compounds ; in vitro biological potency ; medical plant ; marsh woundwort ; clover sprouts ; Trifolium ; isoflavones ; prostate cancer ; breast cancer ; cytotoxic ; COVID-19 ; HPLC-UV ; quality control of Umckaloabo ; Pelargonium sidoides root extract ; umckalin ; Astragalus fruticosus ; HPLC–MS/MS profiling ; colorectal cancer ; cytotoxic activity ; contezolid ; CSF ; plasma ; capillary electrophoresis ; mass spectrometry ; online preconcentration ; stacking ; tyrosine kinase inhibitors ; tiamulin ; withdrawal time ; Crocus sativus L. ; phorone ; crocins ; picrocrocin ; safranal ; DPPH ; FRAP ; total antioxidant capacity ; antimicrobial activity ; anticoagulant activity ; antidiabetic activity ; Allium cepa L. ; direct thermal desorption–gas chromatography–mass spectrometry ; multi-response optimization ; onion ; organosulfur compounds ; LC-MS ; tissue ; morphine ; fentanyl ; opioids ; antipsychotic drug LQFM05 ; sample pretreatment ; tissue distribution ; bioanalytical methods ; LC-QTOF/MS ; antioxidants ; radioresistant microorganisms ; radioprotection ; biofilm ; co-operative growth ; oxidative stress ; chlorogenic acids ; ion trap MS analyzer ; isomers recognition ; ERMS ; solid-phase extraction ; CDK4/6 inhibitors ; therapeutic drug monitoring ; liquid chromatography ; bioanalysis ; patient plasma ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Neurodegenerative diseases (NDs) are a heterogeneous group of complex diseases characterized by neuronal loss and progressive degeneration of different areas of the nervous system. NDs represent a significant health problem worldwide, with an increasing incidence rate. Although the exact pathogenesis of NDs remains unclear, a complex interaction among genetic, epigenetic, and environmental factors has been proposed. To date, no effective therapeutics have been developed to slow, halt, or prevent any NDs. Thus, information on the molecular mechanisms underlying the pathogenesis of NDs is strongly sought after. This Special Issue collected papers discussing advances in the field of NDs.
    Keywords: menopause ; estrogen ; neurodegenerative disease ; Alzheimer’s disease ; IGF-1 ; NMDAR ; Parkinson’s disease ; neurodegeneration ; genetics ; non-coding RNAs ; microbiome ; mitochondria ; epigenetics ; biomarkers ; precision medicine ; EAE ; glutamate receptor antagonist ; excitotoxicity ; oxidative stress ; -SH groups ; superoxide dismutase ; circulating microRNA ; relapsing–remitting multiple sclerosis ; secondary progressive multiple sclerosis ; biomarker ; neuroinflammation ; Rab1 ; GTPases ; secretory pathway ; Golgi fragmentation ; autophagy ; α-synuclein ; LRRK2 ; mercury ; central nervous system ; proteomic ; motor functions ; rotenone ; dopamine ; dopamine-D3-receptor ; buspirone ; chicoric acid ; peripheral immune system ; spleen ; gut ; 6-hydroxydopamine ; apoptosis ; mitochondrial membrane potential ; neurodegenerative diseases ; cell culture techniques ; neurodegenerative disorders ; neuroprotective effect ; biological products ; striatum ; caspase-3 ; spiny projection neurons ; dendritic spines ; long-term depression ; Q-VD-OPh ; mice ; blood–brain barrier ; extracellular matrix ; fibronectin ; liposomes ; multiple sclerosis ; nanomedicine ; oligodendrocytes ; PLGA ; remyelination ; therapeutic targets ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In recent years, there has been a growing need for both nutritional and healthy foods with superior functional properties. In this line, bioactive compounds are economically available in different foods systems with limitations in quality and functionality.The present Special Issue is placed in this context, and aimed to provide a collection of modern chemical strategies developed with the intent of extracting, characterizing, tracing, or authenticating food bioactive compounds. Original research articles dealing with innovative techniques for the extraction (e.g., green chemistry) of bioactive compounds were welcomed. In addition, when discussing modern analytical methods, the structural characterization and identification of these active components were required. Attention was also devoted to theoretical aspects of the determination of the bioactivity and mechanisms of action of food bioactive compounds, as well as challenging properties for application as drug agents. Review articles providing an overview of the latest trends in this area of interest were also very welcomed.
    Keywords: Tartary buckwheat powder ; airflow ultrafine-grinding ; grinding pressure ; particle size ; chemical compositions ; morphology ; Parkinson’s disease ; CPO-B ; MPP+ ; Erk1/2 ; neuroprotection ; soluble dietary fiber ; resistant oligosaccharide ; viscous fiber ; gut microbiota ; human health ; effect-directed analysis ; healthy food ; food processing ; adulteration ; authentication ; hairless canary seed groats ; carotenoid identification ; LC-MS/MS ; baked products ; phenolic compounds ; high hydrostatic pressure ; reactive oxygen species ; biosynthesis ; extraction ; stress response ; cell wall modification ; flavonoid extraction ; mung bean ; phenolic extraction ; pressurized liquid extraction ; response surface methodology ; diabetes ; Bauhinia strychnifolia ; α-glucosidase ; dipeptidyl peptidase-IV ; glucose uptake ; flavonoids ; milk phospholipids ; sphingomyelin ; skin hydration ; Nrf2 ; hyaluronic acid ; Cupressus sempervirens essential oil ; antibacterial activity ; membrane permeability ; replication and transcription inhibition ; computational toxicology ; molecular docking ; zebrafish ; byproducts ; enriched pasta ; potato peel ; physical properties ; sensory traits ; spearmint ; commercial materials ; antimicrobial activity ; antioxidant activity ; untargeted metabolomics ; bioprospection ; Cowpea ; Mo soil treatment ; Fe and Zn foliar application ; ODAP ; neurotoxin ; grass pea ; Lathyrus sativus ; growth stage ; neurolathyrism ; non-protein amino acids ; Canarium odontophyllum ; cytotoxicity ; antioxidant ; fatty acid profiles ; geographical location ; acrylamide ; antioxidant capacity ; ascorbic acid ; cell cycle ; ionome ; oxidative stress ; Schizosaccharomyces pombe ; rosehip ; bioactive compounds ; encapsulation ; specialized pro-resolving mediators ; resolvins ; maresins ; annexins ; lipoxins ; protectins ; glial cells ; neuroinflammation ; neurodegeneration ; cerebrovascular disorders ; multiple sclerosis ; dementia ; bromelain ; expression ; purification ; catalytic activity ; metal ion ; traditional medicine ; Bergenia ligulata ; anti-urolithiatic ; anti-pyretic ; anti-diabetic ; anti-inflammatory ; cardiovascular diseases ; olive oil ; fluorescence spectroscopy ; olive oil conservation ; packaging ; quality parameters ; olive mill wastewater ; microfiltration ; fermentation ; microbial pool ; hydroxytyrosol ; functional beverage ; antidiabetic potential ; constant electric field ; drying ; magnetic field ; pretreatment ; pulsed electric field ; total phenolic content ; antimicrobial agents ; Staphylococcus aureus ; hemolysis ; membranes ; fluidity ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Taurine (2-aminoethanesulfonic acid) has been reported to have a lot of physiological and pharmacological functions in various tissues, cells, and organelles in many species since discovered in the gall bladder of bovine in 1827, and its novel functions and roles have now been focused in many fields. This Special Issue consisted of eight original and two review articles contains the newest findings on the roles of taurine as an essential nutrient for development and growth in fetuses and infants, and functional maintenance in the brain, skeletal muscles, and others in adults, in mammalian, chicken, and fish.
    Keywords: taurine ; NAT ; carnitine ; ACT ; acetyl-CoA ; mitochondria ; endurance exercise ; skeletal muscle ; transport ; blood-testis barrier ; seminiferous tubules ; antioxidant ; infertility ; CRF ; chicks ; isolation stress ; sedation ; hypnosis ; osmolytes ; muscle ; Duchenne Muscular Dystrophy ; mdx ; 2-aminoethanesulfonic acid ; developmental programming ; GABAA receptors ; glycine receptors ; neural progenitor ; neural stem cell ; perinatal nutrition ; placental transfer ; obesity ; taurine transporter ; N-chlorotaurine ; lung inflammation ; cytokine ; muscle wasting ; atrophy ; diabetes ; GLUT-2 ; oxidative stress ; glycogen ; glucose metabolism ; knockout mice ; brain ; body weight ; behavior ; TXNIP ; Ets-1 ; ERK ; fat metabolism ; liver fat accumulation ; RNA–Seq ; Epinephelus coioides ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue, “Biotechnology Applications of Microalgae”, is focused on the latest novel advances related to the production of different bioactive compounds from microalgae and their biotechnological use.
    Keywords: enzymatic activity ; fluid dynamics ; microalgae ; oxidative stress ; static magnetic fields ; violaxanthin ; reactive oxygen species ; ascorbic acid ; glutathione ; tocopherols ; phenolic compounds ; carotenoids ; thraustochytrids ; antioxidants ; saturated fatty acids ; polyunsaturated fatty acids ; transcriptomics ; sustainability ; industrial valorization ; carbon dioxide fixation ; biological activities ; phytosterol ; Saccharomyces cerevisiae ; Phaeodactylum tricornutum ; Sparus aurata ; β-glucans ; pulse feeding ; immune tolerance ; salt stress ; seawater cultivation ; Internet of Things ; proteomics ; blue light ; astaxanthin ; fatty acid ; heme ; cell wall ; salicylic acid ; fucoxanthin ; green consumption ; food consumption ; amino acids ; carbohydrates ; radical scavenging activity (RSA) ; RP-HPLC ; Chromochloris zofingiensis ; lutein ; CO2 aeration ; cGMP-dependent kinase ; biodiesel ; microalgal biotechnology ; natural antioxidants ; Yarrowia lipolytica ; Chlorella vulgaris ; growth ; fatty acids ; Spirulina ; healthcare ; space missions ; medicine applications ; microgravity effects ; humic substances ; microalgae cultivation ; hormetic effects ; increased nutrient availability ; improved protection against abiotic stress ; higher accumulation of bioactive ingredients ; enhanced microalgal productivity ; Dunaliella salina ; chlorpropham ; herbicide ; phytoene ; Nannochloropsis ; mixotrophy ; photobioreactors ; CHN analysis ; metabolomics ; bioassay ; cell death pathway ; autophagy ; antitumoral activity ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: The articles discussed in this reprint show the potential health benefits of nutraceuticals, which are products containing bioactive compounds that can prevent and treat chronic diseases. This book explores various functional ingredients, including plant-derived products, mushrooms, microalgae, and goji berries, for their therapeutic, hypoallergenic, and sporting purposes. The study of the gut microbiome and its interactions with dietary components is also discussed. Additionally, the importance of sustainable and environmentally friendly practices in the food industry also stands out. As consumers seek out natural and functional food products, continued research on and the development of nutraceuticals will be critical in promoting healthy aging and addressing chronic diseases.
    Keywords: goji berry ; functional foods ; antioxidant ; health ; antibacterial ; health promotion ; chitosan ; high-fat diet ; hyperlipidemia ; dyslipidemia ; cardiovascular diseases ; obesity ; Basidiomycetes-X (BDM-X) ; Shirayukidake ; Ceraceomyces tessulatus ; Mibyou ; Mibyou-care functional food ; healthy lifespan expenditure ; buckwheat ; fava bean ; hemp ; anthocyanin ; flour fortification ; functional food ; berries ; soft fruit ; agricultural waste ; bilberry ; anti-allergy ; Coriandrum sativum L. ; cedar pollen ; degranulation ; RBL-2H3 cell ; coriander leaf ; antioxidants ; aging theories ; cohort study ; healthy diet ; longevity ; nutraceuticals ; oxidative stress ; reactive oxygen species ; senescence ; vitamins ; fruit ; food ; sugar ; athlete ; comfort ; mucilages ; ecological functions ; human and animal health-promoting properties ; application in agriculture ; genes ; nutritional components ; quercetin ; docosahexaenoic acid ; pectin ; polymeric conjugate ; biological properties ; anti-inflammation ; antioxidant activity ; chronic disease ; diabetes ; phenols ; testa ; prebiotic ; alginate ; alginate oligosaccharides ; intestinal microbiota ; microbial metabolites ; short-chain fatty acids ; colon simulation ; European black elderberry extract ; natural substance ; anthocyanins ; phenolic compounds ; SARS-CoV-2 ; antiviral ; COVID-19 ; coronavirus ; SARS-CoV-2 variants of concern ; microalgae ; mitochondria ; PUFA ; carotenoids ; sterols ; polyphenols ; chronic diseases
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The COVID-19 pandemic is considered to be a global public health emergency. Due to its route of transmission via contact with droplets and aerosols, dentists are at high risk of acquiring an infection while treating patients. The impact of the coronavirus on the dental community is eminent, and the greatest challenge is how we can offer dental treatment despite the outbreak. Dental education programs in both under- and postgraduate forms will also suffer from the ramifications of the pandemic. This topical collection offers many perspectives on the management of the COVID-19 crisis within the dental community.
    Keywords: COVID-19 ; dentistry ; teleassistance ; remote sensing technology ; orthodontics ; teledentistry ; teleorthodontics ; SARS-CoV-2 ; dental care ; children ; dentist-patient relation ; pandemic ; oral oncology ; dental ; oral surgery ; head and neck cancer ; cancer patients ; oral manifestation ; xerostomia ; dysgeusia ; coronavirus pandemic ; temporomandibular disorders ; bruxism ; orofacial pain ; dental anxiety ; periodontitis ; bio-inspired ; nonsurgical periodontal therapy ; dental hygiene ; Angiotensin Converting Enzyme 2 (ACE-2) ; saliva ; inflammation ; oxidative stress ; dental practice ; n/a ; candidiasis ; critical care ; macroglossia ; oral manifestations ; pressure ulcer ; prone position ; oral health ; IES-R ; DASS-21 ; stress ; anxiety ; depression ; dentists ; psychological impact ; RT-PCR testing ; antigen ; antibody ; aerosols ; body fluids ; viral load ; epidemiological monitoring ; adverse effects ; BNT162 vaccine ; cross-sectional studies ; Czech Republic ; drug-related side effects and adverse reactions ; health personnel ; mass vaccination ; prevalence ; coronavirus ; resumption ; mitigating measures ; vaccination ; rapid testing ; Google Trends ; COVID-19 pandemic ; dental education ; OSPE ; communications skills ; remote ; surgery ; oral ; dental implantation ; retrospective studies ; population characteristics ; cross-sectional study ; oral cavity ; taste disorders ; maxillofacial injuries ; facial bone fractures ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The Special Issue “Fucoxanthin and Astaxanthin—Production, Biofunction, and Application” focuses on the research of marine fucoxanthin and astaxanthin and contains two reviews, ten articles, and one communication.
    Keywords: brown seaweed ; fucoxanthin ; osteoclastogenesis ; MAP kinase ; Nrf2 ; oxidative stress ; calcification ; heart valve interstitial cell ; Haematococcus pluvialis ; astaxanthin ; nonmotile cells ; phosphorus deficiency ; Scenedesmus ; Coelastrella ; carotenoprotein ; astaxanthin-binding protein ; diatom ; eicosapentaenoic acid (EPA) ; transcriptomics ; trophic transition ; marine carotenoid ; crustacyanin ; European lobster ; NusA-tag ; Escherichia coli ; delivery system ; skin ; cosmetics ; drugs ; drug release ; Phaeodactylum tricornutum ; high performance countercurrent chromatography (HPCCC) ; countercurrent chromatography (CCC) ; centrifugal partition chromatography (CPC) ; microalgae ; macroalgae ; carotenoids ; Scopus ; bibliometric ; applications ; biosynthesis ; health benefits ; production ; benign prostatic hyperplasia ; pharmacodynamics ; SOD activity ; RPE cells ; phagocytosis ; visible light ; docosahexaenoic acid ; photosynthetic efficiency ; microfluidics ; photobioreactor ; monocaprin ; bioavailability ; fucoxanthinol ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PN Chemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The purpose of this reprint based on the Special issue "Molecules in Diabetes Melitus, Dyslipidemia and Cardiovascular Disease”, IJMS journal, MDPI, is to present the impact in clinical practice as well as in medical research of novel molecules that have been introduced in the treatment of diabetes mellitus, dyslipidemia, and cardiovascular disease.
    Keywords: nicotinamide mononucleotide ; retinal ischemia/reperfusion ; oxidative stress ; neuroprotection ; inflammation ; sacubitril/valsartan ; mortality ; morbidity ; heart failure ; ejection fraction ; diabetes mellitus ; α-glucosidase ; abietane diterpenoids ; levopimaric acid ; quinopimaric acid ; molecular docking ; ADMET ; PFK15 synthesis ; sunitinib L-malate ; HUVEC ; angiogenesis ; synergy ; cardiovascular medicine ; diabetes ; hypertension ; GIP ; GLP-1 ; glucagon ; incretins ; LY3298176 ; meta-analysis ; obesity ; SUMMIT ; SURMOUNT ; SURPASS ; SYNERGY ; Tirzepatide ; common carotid artery occlusion ; retinal ischemia ; dyslipidemia ; statin ; children ; adolescents ; metabolic syndrome ; liver ; hsa-miR-193b-3p ; peroxisome proliferator activated receptor gamma coactivator 1 alpha ; lipid metabolism ; n/a ; empagliflozin ; type 2 diabetes mellitus ; leptin ; sphingolipids ; sphingomyelinase ; vasorelaxation ; endothelial nitric oxide synthase ; type 2 diabetes ; thromboxane prostanoid receptor ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Tryptophan is a rate-limiting essential amino acid and a unique building block of peptides and proteins. This largest amino acid serves as the precursor for the important endogenous indoleamines serotonin, N-acetylserotonin, and melatonin that act as neurotransmitters, neuromodulators, and neurohormones. Kynurenic acid is the most potent endogenous antiexitotoxic agent. Other highly relevant pathways of tryptophan are the reversible transamination to indole-3-pyruvate with formation related indolic acids that act as potent antioxidant agents. Tryptophan metabolites, such as melatonin, and structurally related agents, such as indole-3-propionic acid, act as potent catalytic antioxidants and bioenergetic agents that facilitate regeneration and protection against stress and aging. Several indole compounds act as uremic toxins since these agents can induce radical formation that is associated with enhanced oxidative stress and damage. The exploration of the effects of these protective and toxic tryptophan derived agents has revealed important molecular mechanisms and mediators of adaptation and aging. Research on tryptophan in nutrition and health can facilitate the development of new approaches to extend human health and life span. Amino acids are the building blocks of life that enable repair, as well as recycling and regeneration. Research on nutrients like amino acids, such as tryptophan and its metabolites, as well as peptides and proteins, or extracts containing this molecular metabolism modifiers can improve health. Research into the indololome is a new emerging and rapidly growing field of utmost relevance to science and society.
    Keywords: tryptophan ; kynurenine ; kynurenic acid ; FICZ ; AhR ; melanoma ; proliferation ; cell death ; aryl hydrocarbon receptor ; chronic kidney disease ; developmental origins of health and disease (DOHaD) ; hypertension ; indole ; melatonin ; serotonin ; uremic toxin ; virus ; immunity ; codon ; depression ; chronic mild stress ; oxidative stress ; tryptophan catabolites pathway ; methylation ; expression ; escitalopram ; 5-hydroxytryptophan ; natural sources ; microbial production ; biosynthetic pathways ; physiological effects ; animal ; human ; kynurenine pathway ; MEL biosynthesis ; Saccharomyces cerevisiae ; yeast ; tryptophan extraction ; LC-MS/MS ; soybean ; skin ; atopic dermatitis ; psoriasis ; severe acute respiratory syndrome ; SARS-CoV-2 ; COVID-19 ; malignant melanoma ; urine ; autofluorescence ; transplantation ; ischemia-reperfusion ; tolerance ; rejection ; indoleamine-2,3-dioxygenase ; L-tryptophan ; amino acids ; MAC-T cell ; proteomics ; omics ; β-casein ; mTOR ; systemic inflammation ; dysbiosis ; gut ; microbiota ; obesity ; mice ; tyrosine ; cytokines ; behavior ; inflammation ; liver morphology ; color ; cell culture media ; LC-MS ; antioxidant ; cytotoxicity ; biomanufacturing ; 5-hydroxytryptamine ; secretion ; metabolism ; nitrofurantoin ; antibiotics ; human serum albumin ; molecular interactions ; FTIR ; fluorescence ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: The aim of this Special Issue was to publish high-quality papers on poultry nutrition and the inter-relations between nutrition, metabolism, gut microflora, and poultry performance. Therefore, we present here original research articles in the following topics:- the nutrient requirements of poultry;- the impact of dietary fibre on poultry health and performance;- the use of feed additives to improve gut microflora and performance;- the effect of feeding on poultry meat and egg quality;- factors that cause variation in feed ingredients used in poultry diets;- alternative feed ingredients for use in poultry feed formulations;- the impact of gastrointestinal pH on nutrient bioavailability and the intestinal microbiota in poultry;- phytate and xylan ‘susceptibility’ in relation to the effects of enzymes;- factors that influence reactivity and enzyme efficacy;- in vitro models to determine the digestibility of poultry diets.
    Keywords: geese ; feeding ; rye ; oats ; slaughter value ; quality traits ; date by-product ; date stone ; poultry ; nutritive value ; production performance ; amino acids ; broiler ; heat stress ; heat tolerance ; protein metabolism ; microbial metabolites ; gastrointestinal peptides ; glycolipid metabolism ; chicken ; high temperature ; regulatory factors ; protein degradation ; growth ; broilers ; betaine ; performance ; meat quality ; blood constituents ; ZnNPs ; CurNPs ; Bacillus ; microbial aspects ; acute heat stress ; cecum metagenome ; insoluble fiber ; steam-exploded pine ; antioxidant ; growth performance ; gut microbiota ; quercetin ; protease ; dietary protein ; nutrient utilization ; organic ; aromatic plants ; laying hens ; Salvia officinalis L. ; malondialdehyde (MDA) ; Enterobacteriaceae ; poultry fat ; plasma lipid ; muscle FAs content ; aging corn ; oxidative stress ; broiler performance ; intestinal health ; microbiota ; fermented feed ; laying hen ; cecal microbiota ; gut health ; nutrition ; egg quality ; rapeseed cake ; fermentation ; hydrobarothermal treatment ; age ; amino acid ; barley ; corn ; digestibility ; PBMCs ; primary cell culture ; immunomodulating compounds ; breast ; carcass traits ; cinnamon bark ; L-arginine ; in ovo feeding ; antioxidant capacity ; slow-growing chicken ; non-starch polysaccharide degradation ; nutrient digestibility ; ginger ; hematological parameters ; curcumin ; physiological efficiency ; poultry welfare ; stress ; turkey ; neurodegeneration ; methionine ; lysine ; arginine ; Gallus domesticus ; Tribulus Terrestris ; histology ; liver ; kidney ; intestine ; phytase ; bone mineralization ; phytate phosphorus ; broiler chickens ; Acacia Senegal ; performance, gene expression ; morphology ; broiler breeder ; glycerol ; mineral ; superdosing ; yolk sac ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSV Zoology & animal sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-08-08
    Description: This Special Issue of Cancers contains research and review articles on “PARPs, PAR and NAD metabolism and their inhibitors in Cancer”. It focuses on selected papers from the PARP2019 conference on “New Avenues in Basic and Translational PARP research”, that took place in Budapest (Hungary), on 20–23 May 2019.
    Keywords: MDS ; PARP inhibitors ; olaparib ; hematopoietic differentiation ; PARP1 ; AML ; poly-ADP-ribose polymerase 1 (PARP1) ; brahma-related gene 1 (BRG1) ; histone acetyltransferase p300 (EP300) ; gene transcription ; cancer cell ; head and neck squamous cell carcinoma ; CAL27 ; SCC90 ; p60/p150 CAF-1 subunits ; DNA repair ; homologous recombination ; biomarkers ; personalized treatment ; UVB ; PARP ; mitochondria ; metabolism ; biogenesis ; autophagy ; carcinogenesis ; transcription ; PARylation ; DNA damage ; transcription silencing ; carryover effect ; TOP1 activity ; TDP1 ; irinotecan ; immunomodulation ; tumor microenvironment ; trapping ; cancer therapeutic strategy ; arginine-specific mono-ADP-ribosylation ; bacterial toxin ; cholera toxin ; ART1 ; ARH1 ; tumorigenesis ; loss of heterozygosity ; membrane repair ; gender bias ; Syk ; EGFR ; squamous cell carcinoma ; PARP-Akt interplay ; PI3K ; mTOR ; cytoprotection ; apoptosis resistance ; oxidative stress ; mitochondrial protection ; drug development ; synthetic lethality ; clinical trials ; ADP-ribosylation ; cancer ; macrodomain ; ADP-ribosyl hydrolase ; ARTD ; MACROD1 ; MACROD2 ; TARG1 ; ATM ; ATR ; PARP inhibitor ; prostate cancer ; pancreatic cancer ; lung cancer ; Tumor microenvironment ; PARPs ; hypoxia ; CHK1 ; replication stress ; homologous recombination DNA repair ; cell cycle ; cytotoxicity ; PARP Inhibitors ; beta-lapachone ; NQO1 ; PARG ; NAMPT ; cancer therapeutics ; cMET ; poly (ADP-ribose) glycohydrolase ; radiosensitization ; poly (ADP-ribose) polymerase ; ES cells ; poly (ADP-ribose) polymerase inhibitors (PARPi) ; ataxia telangiectasia and Rad3 related inhibitors (ATRi) ; cell cycle checkpoints ; NAD+ ; NMNAT1 ; cisplatin ; chemotherapy ; apoptosis ; osteosarcoma ; DNA damage response ; immunotherapy ; immune checkpoint inhibitor ; PD-1 ; PD-L1 ; CTLA-4 ; combination therapy ; solid tumors ; the PARP inhibitor PJ34 ; distorted mitotic spindles ; exclusive eradication of human cancer cells ; nucleolus ; poly(ADP-ribosyl)ation ; ARTDs ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSB Biochemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The impairment of neurogenesis may be induced after pre- and post-natal chemical and biological toxin, alcohol, or radiation exposure, drug treatment, hormone imbalances, stress, pain, hypoxia, brain trauma, malnutrition, and aging. It also occurs as a result of genetic disorders such as Down syndrome (DS), autism, fragile X syndrome (FXS), neurological disorders including Alzheimer's disease (AD), Parkinson's disease (PD) epilepsy, and Huntington's disease (HD), and neuropsychiatric disorders such as depression and schizophrenia; however, the causal relationship between the impairment of neurogenesis and neurological and neuropsychiatric disorders remains unknown. In this Special Issue, entitled “Induced Impairment of Neurogenesis and Brain Diseases”, original animal or cell experimental research and review papers were combined to discuss different causes of the impairment of neurogenesis, relevant neurobehavioral changes, molecular mechanisms, and therapeutic approaches. The aim is to update researchers and clinicians about the complexity of the development of the impairment of neurogenesis, the importance of the involvement of the impairment of neurogenesis in neurological and neuropsychiatric disorders, and to provide some clues for designing novel therapeutic approaches by targeting the impairment of neurogenesis to effectively prevent or treat different genetic, neurological, and neuropsychological disorders.
    Keywords: neurogenesis ; TGF-β ; smad ; depression ; stress ; complementary and alternative medicines ; natural products ; peripheral nerve injury ; nerve repair ; nerve regeneration ; functional recovery ; neuroinflammation ; microglia ; TSPO ; mitochondria ; cytokines ; antioxidants ; γ-irradiation ; miR-34a-5p ; tia1 ; N6-methyladenosine ; Mettl3 ; Mettl14 ; Fto ; Ythdf1 ; neurodevelopment ; neurodegeneration ; SMG6 ; NMD ; neurodevelopmental syndromes ; ionizing radiation ; aging ; brain ; oxidative stress ; mitochondrial dysfunction ; DNA damage ; gut microbiota ; gut-brain axis ; adult neurogenesis ; ageing ; neural stem cells ; nutrients ; polyphenols ; TRIM32 ; excitatory-inhibitory imbalance ; cortex development ; ASD ; NPCs ; GHSR1 ; ghrelin ; hypoxia ; transcription factors ; progenitor cells ; adult hippocampal neurogenesis ; Alzheimer’s disease ; Aβ peptide ; DNA methylation ; gene expression ; NXN ; CNTNAP1 ; SEPT5-GP1BB ; TBX5 ; miR-146b ; cognition ; anxiety ; astrocytes ; neuronal development ; Gdnf ; microcephaly ; MCPH1 ; central domain ; brain development ; gonad development ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The book is a reprint of a Special Issue with the same title published online in the chemical journal Molecules (ISSN 1420-3049) within the section of Medicinal Chemistry. It was edited by academic guest editors from September 2020 to April 2022. In total, it includes eighteen research/review articles including the editorial.
    Keywords: oxygen detection ; dendrogram analysis ; hierarchical clustering ; cancer cells ; luminescence lifetime ; hydrogen peroxide ; oxidative stress ; photodynamic therapy ; time-resolved imaging ; breast cancer ; NRF2 ; polyphenols ; melatonin ; acute myeloid leukemia (AML) ; metformin ; MCL-1 inhibitor S63845 ; reactive oxygen species (ROS) ; AQP3 ; AQP5 ; Anneslea fragrans ; antioxidant ; guided isolation ; flavonoid glycosides ; spheroids ; HT29 cells ; cluster analysis ; principal component analysis ; hydrolysable tannins ; HHDP-digalloylglucose isomer ; dihydroxyphenyl-γ-valerolactone ; autophagy ; colorectal cancer cells ; reactive oxygen species ; endoplasmic reticulum stress ; pentoxifylline ; astaxanthin ; particle encapsulation ; ionizing radiations ; macrophages ; radiation-induced fibrosis ; Rhopilema nomadica ; apoptosis ; cell cycle arrest ; HepG2 ; soybean ; peptides ; antioxidant capacity ; magnetite nanoparticles ; conjugation ; multicomponent reaction ; copper complexes ; glutathione depletion ; cysteine ; Casiopeina ; intermediate ; copper reduction ; papaverine ; cancer ; morphology ; proliferation ; cell cycle ; chain-transfer agent ; chemotherapy ; free radical chain reaction ; lipid peroxidation ; lipophilic thiol ; oxidative cell death ; prooxidative drug ; radical propagation ; rate-limiting step ; mitochondria ; bioenergetics ; anticancer ; cheminformatics ; in silico ; Keap1 ; molecular docking ; molecular dynamics ; myeloperoxidase ; NADPH oxidase ; seed antioxidant peptide ; xanthine oxidase ; osteosarcoma ; naringenin ; ROS ; ER stress ; ferroptosis ; inducers ; inhibitors ; drug-likeness ; neurodegenerative ; polyphenol ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This reprint presents recent advances in understanding the molecular processes that take place in adipose tissue inflammation in the context of obesity. It discusses the impact of adipose tissue inflammation on systemic metabolic alterations associated with excess adiposity, as well as its repercussion in several pathological conditions that may help to understand obesity-associated metabolic derangements.
    Keywords: adipose tissue ; fatty acid-binding protein 4 ; proinflammatory adipokine ; insulin resistance ; gestational diabetes mellitus ; type 2 diabetes mellitus ; adiponectin ; body mass index ; colostrum ; leptin ; phagocytes ; obesity ; overweight ; oxidative stress ; adipose tissue inflammation ; pancreatic ductal adenocarcinoma ; BDNF ; Val66Met polymorphism ; adipogenesis ; arterial thrombosis ; physical exercise ; Il-6 ; Mcp-1 ; Tnf-α ; liver ; inflammation ; steatosis ; liver resection ; liver transplantation ; lipectomy ; type 2 diabetes ; bariatric surgery ; mast cells ; coagulopathy ; COVID-19 ; cytokine storm ; SARS-CoV-2 ; adipokines ; body fat distribution ; obesity pathophysiology ; hypoxia ; steroid receptor RNA activator 1/SRA1 ; TLRs ; IRFs ; type-2 diabetes ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: The discovery of new drugs is one of pharmaceutical research's most exciting and challenging tasks. Unfortunately, the conventional drug discovery procedure is chronophagous and seldom successful; furthermore, new drugs are needed to address our clinical challenges (e.g., new antibiotics, new anticancer drugs, new antivirals).Within this framework, drug repositioning—finding new pharmacodynamic properties for already approved drugs—becomes a worthy drug discovery strategy.Recent drug discovery techniques combine traditional tools with in silico strategies to identify previously unaccounted properties for drugs already in use. Indeed, big data exploration techniques capitalize on the ever-growing knowledge of drugs' structural and physicochemical properties, drug–target and drug–drug interactions, advances in human biochemistry, and the latest molecular and cellular biology discoveries.Following this new and exciting trend, this book is a collection of papers introducing innovative computational methods to identify potential candidates for drug repositioning. Thus, the papers in the Special Issue In Silico Strategies for Prospective Drug Repositionings introduce a wide array of in silico strategies such as complex network analysis, big data, machine learning, molecular docking, molecular dynamics simulation, and QSAR; these strategies target diverse diseases and medical conditions: COVID-19 and post-COVID-19 pulmonary fibrosis, non-small lung cancer, multiple sclerosis, toxoplasmosis, psychiatric disorders, or skin conditions.
    Keywords: COVID-19 ; drug repurposing ; topological data analysis ; persistent Betti function ; SARS-CoV-2 ; network-based pharmacology ; combination therapy ; nucleoside GS-441524 ; fluoxetine ; synergy ; antidepressant ; natural compounds ; QSAR ; molecular docking ; drug repositioning ; UK Biobank ; vaccine ; LC-2/ad cell line ; drug discovery ; docking ; MM-GBSA calculation ; molecular dynamics ; cytotoxicity assay ; GWAS ; multiple sclerosis ; oxidative stress ; repurposing ; ADME-Tox ; bioinformatics ; complex network analysis ; modularity clustering ; ATC code ; hidradenitis suppurativa ; acne inversa ; transcriptome ; proteome ; comorbid disorder ; biomarker ; signaling pathway ; druggable gene ; drug-repositioning ; MEK inhibitor ; MM/GBSA ; Glide docking ; MD simulation ; MM/PBSA ; single-cell RNA sequencing ; pulmonary fibrosis ; biological networks ; p38α MAPK ; allosteric inhibitors ; in silico screening ; computer-aided drug discovery ; network analysis ; psychiatric disorders ; medications ; psychiatry ; mental disorders ; toxoplasmosis ; Toxoplasma gondii ; in vitro screening ; drug targets ; drug-disease interaction ; target-disease interaction ; DPP4 inhibitors ; lipid rafts ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This reprint presents information to update the state-of-the-art knowledge on young, professional or recreational, male and female athletes. Moreover, it addresses current gaps in the literature on issues that have an impact on athletes (e.g., Crohn’s disease, Olympic weightlifting, and velocity speed loss). Importantly, this reprint contributes to knowledge on how to improve load monitoring (of training and competition) and health care for athletes through direct or indirect research.
    Keywords: football ; male ; training ; youth ; RPE ; GPS ; running ; high-speed running ; sprint ; performance ; load monitoring ; match load ; player load ; long-term ; talent identification ; team sport ; multivariate analysis ; electromyography ; lower trapezius ; muscle strength ; shoulder kinematics ; sports injuries ; psychological factors ; Bayesian network ; sport metabolomics ; oxidative stress ; hormone signalling ; adiponectin ; basketball ; n/a ; correlation ; external intensity ; inertial device ; internal intensity ; perceived exertion ; SIATE ; agility ; soccer ; flexibility ; predictors ; outcome ; strength ; power ; reactive strength ; players ; plyometric training ; resistance training ; external load ; contextual variables ; amateur ; home match ; away match ; combat sports ; elite athletes ; rapid weight loss ; extreme weight loss ; weight management ; female ; Hooper Index ; internal load ; load ; match ; training load ; inflammation ; bowel ; malnutrition ; physical activity ; high-intensity interval training ; sport ; mental load ; Stroop ; triathlon ; sports medicine ; sports physiology ; female athlete ; VO2 max ; ultra-endurance ; bone mass density ; bone remodelling markers ; bone formation ; bone resorption ; athlete ; exercise ; injury ; aquatic training ; bicycling training ; meniscal allograft transplantation ; rehabilitation ; dynamic balance ; range of motion ; external training load ; technology ; wearable inertial measurement units ; heart rate ; monitoring ; sports technology ; load quantification ; competition phases ; exercise monitoring ; athletic performance ; reproducibility ; coping with stress ; SARS-CoV-2 ; COVID-19 ; cross-cultural research ; blood flow restriction ; body composition ; low-intensity aerobic training ; recreational runner ; physical fitness ; vascular responses ; isometric ; jump ; stability ; static balance ; Clean and Jerk ; Olympic exercises ; Power Clean ; Snatch ; Squat ; weightlifting derivatives ; physical exercise ; saliva ; metabolomics ; proteomics ; sex ; hearing-impaired ; skill ; inspiratory muscle training ; center of pressure ; soccer players ; velocity–based training ; one–repetition maximum ; maximum strength ; training efficiency ; ports physiology ; women ; maximal aerobic speed ; athletics ; sprint/power athletes ; endurance athletes ; VDR ; rs2228570 polymorphism ; personality trials ; Big Five ; resilience ; athletes ; car drivers ; mindfulness ; awareness ; psychosocial variables ; fast day ; adaptation ; lifestyle ; men ; mental health ; interlimb ; symmetry ; injury risk ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: 10th Anniversary of Plants—Recent Advances and Perspectives is a scientific paper collection specially published on the anniversary of Plants. Covering all major areas of plant science, it is a valuable guide through current achievements and future discoveries in this scientific field.
    Keywords: Secale cereale ; Secale montanum ; Secale strictum ; QTL mapping ; molecular marker ; self-incompatibility ; fertility ; seed set ; abiotic stress ; cell homeostasis ; heterologous host synthetic approach ; terpenophenolics ; brown spot ; ACT ; fungus culture filtrate ; mycotoxin ; fruit development ; fruit gauge ; VPD ; Mangifera indica ; cell division ; cell expansion ; ripening ; pulegone ; isomenthone ; menthone ; thymol ; p-cymene ; chemotypes ; seasonal variation ; enantiomeric distribution ; label-free proteomics ; Panax ginseng ; ginsenosides ; cytochrome p450 ; UDP-glycosyltransferase ; MEP pathway ; MVA pathway ; TCA/acetone ; methanol/chloroform ; endophytes ; foliar pathogens ; pathogenicity ; taxonomy ; Thymus vulgaris ; Crithmum maritimum ; leather artifacts ; essential oils ; anti-bacterial activity ; Euphorbia dendroides L. ; aerial parts ; polyphenols ; antioxidant activity ; anti-inflammatory activity ; toxicity ; calcium oxalate crystals ; colleter ; extrafloral nectaries ; resin gland ; bud protection ; plant-environment interaction ; carbohydrate metabolism ; microarray ; crop ; rice ; productivity ; endosperm ; geometry ; morphology ; seed shape ; Vitaceae ; exDNA ; environmental DNA ; DNA sensing ; self-DNA inhibition ; autotoxicity ; plant response ; DAMP ; PAMP ; EDAP ; climate change ; food security ; Mediterranean countries ; sustainable exploitation ; phytogenetic resources ; candidate gene ; quantitative trait locus ; recombinant inbred line ; soybean drought tolerance ; weighted drought coefficient ; antioxidants ; biostimulants ; biotic stress ; GABA ; metabolism ; phytohormones ; reactive oxygen species ; signaling ; tricarboxylic acid cycle ; bacterial functions ; co-presence networks ; metagenomics ; microbial ecology ; plant domestication ; trace element ; plant nutrient ; salinity ; antioxidant defense system ; glyoxalase system ; biochar ; licorice ; soil enzymes ; nutrients ; root system ; ALS ; BCAA ; low oxygen ; flooding ; AIP1 ; Eucommia ulmoides Oliver ; trait variations ; probability grading ; quantitative traits ; planting models ; leaves ; cytokinin ; TD-K ; thidiazuron ; INCYDE ; CPPU ; isopentenyl transferase ; IPT ; cytokinin oxidase/dehydrogenase ; CKX ; wheat ; barley ; yield ; cucumber ; QTL-seq ; SNP markers ; white immature fruit skin color ; ecological costs ; germination models ; herbicide resistance ; hydrotime ; target-site resistance ; hydrogen peroxide ; sodium hypochlorite ; generalized regression neural network ; genetic algorithm ; scarification ; seed dormancy ; plant tissue culture ; foliar descriptors ; leaf area ; models ; vine leaves ; Olea europaea L. ; olive ; genotype by sequencing (GBS) ; single-nucleotide polymorphism (SNP) ; whole-genome sequencing (WGS) ; reference genome ; plastid markers ; DNA barcoding ; ISSR markers ; Egyptian barley ; agro-morphological traits ; cluster analysis ; genetic variation ; biplot ; drought stress ; drying processes ; mathematical model ; plant hydric stress tolerance ; rate of weight loss ; RWLMod ; water evaporation ; photosynthesis ; elevated CO2 ; Rubisco ; electron transport ; light ; diurnal cycle ; sexual propagation ; cold stratification ; in situ ; ex situ ; plant endemism ; Morocco ; biodiversity ; ex-situ conservation ; protocols ; germplasm ; forest berries ; brushing ; lettuce ; chicory ; phytochemicals ; antioxidant capacity ; Ziziphus lotus ; phenolics ; SH-SY5Y cell line ; chromatography ; Koelreuteria paniculata ; dry ethanol extracts ; GC-MS analysis ; chemical compounds ; antitumor and antimicrobial activities ; medicinal plant ; bioactive compounds ; plant-derived secondary metabolites (PDSM) ; cell suspension culture (CSC) ; bioreactor engineering ; apple ; Golden Delicious ; Top Red ; fruitlet thinners ; light reactions ; electron transport rate ; photoprotective mechanism ; state transitions ; PSII repair cycle ; vegetation structure ; environmental variables ; PC-ORD ; plant community assembly ; Himalaya ; allopolyploidy ; interspecific hybridization ; unreduced gametes ; cytological diploidization ; genomic changes ; root length ; root/shoot ratio ; specific root length ; Saragolle Lucana ; seed coating ; heavy metals ; evolution ; hyperaccumulation ; black chokeberry (Aronia melanocarpa) ; anthocyanin stability ; herbs ; co-pigmentation ; color stability ; functional foods/beverages ; biotechnological tools ; ethnomedicine ; in vitro culture ; genetic improvement ; pollen ; tip growth ; calcium ; calcium dependent protein kinase ; Rho Guanine Dissociation Inhibitor ; ROP GTPase ; RhoGDI displacement factor ; polarity ; guar ; gene expression ; qRT-PCR ; RNA-Seq ; salt stress ; salt tolerance ; stress ; transcriptome ; D-tagatose ; IFP48 ; induced resistance ; sweet immunity ; sugar-enhanced defense ; Plasmopara viticola ; Botrytis cinerea ; Vitis vinifera ; human diet ; edible wild plants ; Plantago coronopus L. ; Rumex acetosa L. ; Cichorium intybus L. ; Artemisia dracunculus L. ; phytochemistry ; anti-inflammatory properties ; stem photosynthesis ; hydraulic recovery ; soaking ; X-ray micro-CT ; bark water uptake ; embolism ; genetic resources ; Solanaceae ; Cucumis ; Lactuca ; diversity ; vegetables ; genebank ; essential oil ; iNOS ; interleukin ; lavenders ; NF-κB ; glycosyltransferases ; ER-Golgi trafficking ; mechanism of protein sorting ; COPI and COPII complexes ; sequences and motifs involved in trafficking ; Arabidopsis ; gene regulation ; protein-protein interaction ; transcription factor ; WRI1 ; TCP20 ; lipases ; lipid metabolism ; plant-environment interactions ; reproductive development ; vegetative development ; Urtica dioica ; soilless systems ; cultivated nettle ; stress factors ; functional properties ; preharvest sprouting ; MKK3 ; maternal and paternal expressed genes ; imprinted genes ; polycomb repressive complex 2 ; mRNA processing bodies ; ribonucleic binding proteins ; monosomes ; ethylene ; elicitors ; fruit ripening ; ACC synthase/oxidase ; GC-MS ; polyamines ; Vigna genus ; introgression ; hybridisation ; phylogeny ; de novo domestication ; feralisation ; novel ecosystems ; complex networks ; tree communities ; Lantana camara ; Prosopis juliflora ; ascorbic acid ; genetic diversity ; molecular markers ; aquaculture pond sediment ; recovery ; Triticum aestivum ; chlorophyll fluorescence ; wheat grass juice quality ; UV-B radiation ; olive tree ; metabolomic ; phenolic profile ; lipophilic profile ; ecophysiology ; environment ; arbuscular mycorrhizal symbiosis ; comparative transcriptomics ; Arum-type ; Paris-type ; Solanum lycopersicum ; Rhizophagus irregularis ; Gigaspora margarita ; Camelina sativa ; semi-arid lands ; biofuel feedstock ; biodiesel ; renewable diesel ; crop breeding ; transgenesis ; genome editing ; Xanthomonas euvesicatoria ; host associate factor ; comparative genomics ; Cannabis sativa L. ; chemovars ; secondary metabolites ; trichomes ; residual by-products ; biogeography ; cardioid ; islands ; geometric models ; Mediterranean flora ; Silene ; super-ellipse ; abscisic acid ; aromatic herb ; ascorbate-glutathione cycle ; jasmonic acid ; lipoic acid ; oxidative stress ; salicylic acid ; Salvia officinalis ; drought ; state of stress ; tolerance ; avoidance ; stress survival ; amino acids ; nitrate reductase ; glutamine synthetase ; plants mycorrhized ; dark septate ; Daphne genkwa ; Thymelaeaceae ; flavonoids ; design of experiments ; blooming stages ; germination stimulant ; witchweed ; methyl phenlactonoates (MPs) ; Nijmegen-1 ; weed ; plant development ; vasculature ; leaf traces ; structure ; microtomography ; Euphorbiaceae ; in vitro crop ; gamma radiation ; ionizing radiation ; mutants ; Fumaria scheleicheri Soy. Will. ; isoquinoline alkaloids ; HPLC-DAD ; in vitro anti-cholinesterase ; cytotoxic ; antioxidant ; ABC model ; hop ; transcription factors ; type-II MADS box ; type-I MADS-box ; AFLP ; carpological traits ; genetic structure ; molecular systematics ; plastid phylogeny ; Valerianaceae ; auxins ; embryogenic calli ; HPLC ; IAA ; immunohistochemistry ; deficit irrigation ; grape quality ; phenology ; plant diseases ; bacterium ; symptoms ; molecular classification ; common juniper ; common larch ; Cupressaceae ; Pinaceae ; SPME-GC-MS ; volatile compounds ; herbicidal activity ; weed control ; trait association ; GCV ; genetic variability ; genetic advance ; heritability ; PCV ; Cicer arietinum L. ; gold nanoparticles ; carbon nanotubes ; ATR-FTIR spectroscopy ; machine learning techniques ; principal component analysis ; support vector machine classification ; citrus ; melanose ; Diaporthe citri ; epidemiology ; symptomatology ; Pseudomonas cannabina pv. alisalensis ; resistance-nodulation-cell division transporter ; type-three secretion system ; phytoalexin ; brassinin ; glucosinolate ; cabbage ; flowering ; juvenile traits ; genetic stability ; flow cytometry ; somaclonal variation ; thorniness ; carbohydrates ; protein ; lipids ; fatty acids ; minerals ; plastome ; Plicosepalus acaciae ; Plicosepalus curviflorus ; loranthaceae ; mistletoe ; phylogenetic relationship ; plastome structure ; comparative analysis ; magnetic resonance imaging ; Solanum tuberosum ; multi-exponential transverse relaxation ; water stress ; broccoli ; human nutrition ; improved health ; melatonin ; postharvest ; apricot ; pollen tube ; pollination ; Prunus armeniaca ; S-alleles ; Populus ; hexokinase ; sucrose metabolism ; sugar signaling ; stress and defense ; centres of origin ; crop wild relatives ; crop domestication ; cryopreservation ; conservation ; in vitro storage ; ecosystem restoration ; plant breeding ; acidification ; alkalinisation ; bud burst ; freezing ; Malus domestica ; pH ; Picea abies ; Pinus cembra ; histone modification ; Taraxacum kok-saghyz ; natural rubber ; high light stress ; singlet oxygen ; signalling ; GPX5 ; beta cyclocitral ; acrolein ; glutathione peroxidase ; carbonyl ; transcription ; SLIM1 transcription factor ; sulfur deficiency ; Arabidopsis thaliana ; sulfate transporter ; sulfate assimilation ; stress tolerance ; LRR-RLK receptors ; dodders ; parasitic plants ; proteomics ; virus vertical transmission ; CMV-Fny strain ; pseudorecombinant virus ; chimeric virus ; infection rate ; seed-growth tests ; electron microscopy ; circular dichroism spectroscopy ; viral assembly ; Adiantetea capilli-veneris ; demographic analysis ; ecology ; IUCN ; plant conservation ; phytosociology ; rupicolous habitat ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: Studies focusing on the perinatal period face unique challenges, yet research in this area is extremely important, as this period of life is highly delicate and adverse events might have a long-lasting impact. With the advent of powerful high-resolution and high-throughput analytical methods, researchers have started to successfully develop and implement novel approaches in this area. New insights have great potential to be translated into novel diagnostic tools, as well as alternative preventive and treatment approaches. This book collects a series of timely review and original research articles focusing on metabolomic, oxidative, and nitrosative stress in the perinatal period.We would like to thank all involved authors for their high-quality contributions and their commitment to the publication of this work and hope that this book will be a useful resource for students, scientists, and doctors working in this specific area of application.
    Keywords: glutathione ; glutamate ; oxidative stress ; hypoxia ischemia ; endotoxin ; magnetic resonance spectroscopy ; N-acetylcysteine ; vitamin D ; neonatal HIE ; MRS ; preterm birth ; sex differences ; male disadvantage ; female advantage ; bronchopulmonary dysplasia ; retinopathy of prematurity ; necrotizing enterocolitis ; intraventricular hemorrhage ; periventricular leukomalacia ; mortality ; transposition of the great arteries ; balloon atrial septostomy ; hypoxemia ; metabolomics ; newborn ; liquid chromatography-mass spectrometry (LC-MS) ; allopurinol ; hypothermia ; hypoxic-ischemic encephalopathy ; oxidative damage ; donor milk ; treatment ; Holder pasteurization ; breastmilk ; preterm ; antioxidant capacity ; asphyxia neonatorum ; non-invasive diagnostics ; saliva ; neonatal hypoxia–ischemia ; kynurenic acid (KYNA) ; neuroprotection ; hyperoxia ; prematurity ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: 10th Anniversary of Plants—Recent Advances and Perspectives is a scientific paper collection specially published on the anniversary of Plants. Covering all major areas of plant science, it is a valuable guide through current achievements and future discoveries in this scientific field.
    Keywords: Secale cereale ; Secale montanum ; Secale strictum ; QTL mapping ; molecular marker ; self-incompatibility ; fertility ; seed set ; abiotic stress ; cell homeostasis ; heterologous host synthetic approach ; terpenophenolics ; brown spot ; ACT ; fungus culture filtrate ; mycotoxin ; fruit development ; fruit gauge ; VPD ; Mangifera indica ; cell division ; cell expansion ; ripening ; pulegone ; isomenthone ; menthone ; thymol ; p-cymene ; chemotypes ; seasonal variation ; enantiomeric distribution ; label-free proteomics ; Panax ginseng ; ginsenosides ; cytochrome p450 ; UDP-glycosyltransferase ; MEP pathway ; MVA pathway ; TCA/acetone ; methanol/chloroform ; endophytes ; foliar pathogens ; pathogenicity ; taxonomy ; Thymus vulgaris ; Crithmum maritimum ; leather artifacts ; essential oils ; anti-bacterial activity ; Euphorbia dendroides L. ; aerial parts ; polyphenols ; antioxidant activity ; anti-inflammatory activity ; toxicity ; calcium oxalate crystals ; colleter ; extrafloral nectaries ; resin gland ; bud protection ; plant-environment interaction ; carbohydrate metabolism ; microarray ; crop ; rice ; productivity ; endosperm ; geometry ; morphology ; seed shape ; Vitaceae ; exDNA ; environmental DNA ; DNA sensing ; self-DNA inhibition ; autotoxicity ; plant response ; DAMP ; PAMP ; EDAP ; climate change ; food security ; Mediterranean countries ; sustainable exploitation ; phytogenetic resources ; candidate gene ; quantitative trait locus ; recombinant inbred line ; soybean drought tolerance ; weighted drought coefficient ; antioxidants ; biostimulants ; biotic stress ; GABA ; metabolism ; phytohormones ; reactive oxygen species ; signaling ; tricarboxylic acid cycle ; bacterial functions ; co-presence networks ; metagenomics ; microbial ecology ; plant domestication ; trace element ; plant nutrient ; salinity ; antioxidant defense system ; glyoxalase system ; biochar ; licorice ; soil enzymes ; nutrients ; root system ; ALS ; BCAA ; low oxygen ; flooding ; AIP1 ; Eucommia ulmoides Oliver ; trait variations ; probability grading ; quantitative traits ; planting models ; leaves ; cytokinin ; TD-K ; thidiazuron ; INCYDE ; CPPU ; isopentenyl transferase ; IPT ; cytokinin oxidase/dehydrogenase ; CKX ; wheat ; barley ; yield ; cucumber ; QTL-seq ; SNP markers ; white immature fruit skin color ; ecological costs ; germination models ; herbicide resistance ; hydrotime ; target-site resistance ; hydrogen peroxide ; sodium hypochlorite ; generalized regression neural network ; genetic algorithm ; scarification ; seed dormancy ; plant tissue culture ; foliar descriptors ; leaf area ; models ; vine leaves ; Olea europaea L. ; olive ; genotype by sequencing (GBS) ; single-nucleotide polymorphism (SNP) ; whole-genome sequencing (WGS) ; reference genome ; plastid markers ; DNA barcoding ; ISSR markers ; Egyptian barley ; agro-morphological traits ; cluster analysis ; genetic variation ; biplot ; drought stress ; drying processes ; mathematical model ; plant hydric stress tolerance ; rate of weight loss ; RWLMod ; water evaporation ; photosynthesis ; elevated CO2 ; Rubisco ; electron transport ; light ; diurnal cycle ; sexual propagation ; cold stratification ; in situ ; ex situ ; plant endemism ; Morocco ; biodiversity ; ex-situ conservation ; protocols ; germplasm ; forest berries ; brushing ; lettuce ; chicory ; phytochemicals ; antioxidant capacity ; Ziziphus lotus ; phenolics ; SH-SY5Y cell line ; chromatography ; Koelreuteria paniculata ; dry ethanol extracts ; GC-MS analysis ; chemical compounds ; antitumor and antimicrobial activities ; medicinal plant ; bioactive compounds ; plant-derived secondary metabolites (PDSM) ; cell suspension culture (CSC) ; bioreactor engineering ; apple ; Golden Delicious ; Top Red ; fruitlet thinners ; light reactions ; electron transport rate ; photoprotective mechanism ; state transitions ; PSII repair cycle ; vegetation structure ; environmental variables ; PC-ORD ; plant community assembly ; Himalaya ; allopolyploidy ; interspecific hybridization ; unreduced gametes ; cytological diploidization ; genomic changes ; root length ; root/shoot ratio ; specific root length ; Saragolle Lucana ; seed coating ; heavy metals ; evolution ; hyperaccumulation ; black chokeberry (Aronia melanocarpa) ; anthocyanin stability ; herbs ; co-pigmentation ; color stability ; functional foods/beverages ; biotechnological tools ; ethnomedicine ; in vitro culture ; genetic improvement ; pollen ; tip growth ; calcium ; calcium dependent protein kinase ; Rho Guanine Dissociation Inhibitor ; ROP GTPase ; RhoGDI displacement factor ; polarity ; guar ; gene expression ; qRT-PCR ; RNA-Seq ; salt stress ; salt tolerance ; stress ; transcriptome ; D-tagatose ; IFP48 ; induced resistance ; sweet immunity ; sugar-enhanced defense ; Plasmopara viticola ; Botrytis cinerea ; Vitis vinifera ; human diet ; edible wild plants ; Plantago coronopus L. ; Rumex acetosa L. ; Cichorium intybus L. ; Artemisia dracunculus L. ; phytochemistry ; anti-inflammatory properties ; stem photosynthesis ; hydraulic recovery ; soaking ; X-ray micro-CT ; bark water uptake ; embolism ; genetic resources ; Solanaceae ; Cucumis ; Lactuca ; diversity ; vegetables ; genebank ; essential oil ; iNOS ; interleukin ; lavenders ; NF-κB ; glycosyltransferases ; ER-Golgi trafficking ; mechanism of protein sorting ; COPI and COPII complexes ; sequences and motifs involved in trafficking ; Arabidopsis ; gene regulation ; protein-protein interaction ; transcription factor ; WRI1 ; TCP20 ; lipases ; lipid metabolism ; plant-environment interactions ; reproductive development ; vegetative development ; Urtica dioica ; soilless systems ; cultivated nettle ; stress factors ; functional properties ; preharvest sprouting ; MKK3 ; maternal and paternal expressed genes ; imprinted genes ; polycomb repressive complex 2 ; mRNA processing bodies ; ribonucleic binding proteins ; monosomes ; ethylene ; elicitors ; fruit ripening ; ACC synthase/oxidase ; GC-MS ; polyamines ; Vigna genus ; introgression ; hybridisation ; phylogeny ; de novo domestication ; feralisation ; novel ecosystems ; complex networks ; tree communities ; Lantana camara ; Prosopis juliflora ; ascorbic acid ; genetic diversity ; molecular markers ; aquaculture pond sediment ; recovery ; Triticum aestivum ; chlorophyll fluorescence ; wheat grass juice quality ; UV-B radiation ; olive tree ; metabolomic ; phenolic profile ; lipophilic profile ; ecophysiology ; environment ; arbuscular mycorrhizal symbiosis ; comparative transcriptomics ; Arum-type ; Paris-type ; Solanum lycopersicum ; Rhizophagus irregularis ; Gigaspora margarita ; Camelina sativa ; semi-arid lands ; biofuel feedstock ; biodiesel ; renewable diesel ; crop breeding ; transgenesis ; genome editing ; Xanthomonas euvesicatoria ; host associate factor ; comparative genomics ; Cannabis sativa L. ; chemovars ; secondary metabolites ; trichomes ; residual by-products ; biogeography ; cardioid ; islands ; geometric models ; Mediterranean flora ; Silene ; super-ellipse ; abscisic acid ; aromatic herb ; ascorbate-glutathione cycle ; jasmonic acid ; lipoic acid ; oxidative stress ; salicylic acid ; Salvia officinalis ; drought ; state of stress ; tolerance ; avoidance ; stress survival ; amino acids ; nitrate reductase ; glutamine synthetase ; plants mycorrhized ; dark septate ; Daphne genkwa ; Thymelaeaceae ; flavonoids ; design of experiments ; blooming stages ; germination stimulant ; witchweed ; methyl phenlactonoates (MPs) ; Nijmegen-1 ; weed ; plant development ; vasculature ; leaf traces ; structure ; microtomography ; Euphorbiaceae ; in vitro crop ; gamma radiation ; ionizing radiation ; mutants ; Fumaria scheleicheri Soy. Will. ; isoquinoline alkaloids ; HPLC-DAD ; in vitro anti-cholinesterase ; cytotoxic ; antioxidant ; ABC model ; hop ; transcription factors ; type-II MADS box ; type-I MADS-box ; AFLP ; carpological traits ; genetic structure ; molecular systematics ; plastid phylogeny ; Valerianaceae ; auxins ; embryogenic calli ; HPLC ; IAA ; immunohistochemistry ; deficit irrigation ; grape quality ; phenology ; plant diseases ; bacterium ; symptoms ; molecular classification ; common juniper ; common larch ; Cupressaceae ; Pinaceae ; SPME-GC-MS ; volatile compounds ; herbicidal activity ; weed control ; trait association ; GCV ; genetic variability ; genetic advance ; heritability ; PCV ; Cicer arietinum L. ; gold nanoparticles ; carbon nanotubes ; ATR-FTIR spectroscopy ; machine learning techniques ; principal component analysis ; support vector machine classification ; citrus ; melanose ; Diaporthe citri ; epidemiology ; symptomatology ; Pseudomonas cannabina pv. alisalensis ; resistance-nodulation-cell division transporter ; type-three secretion system ; phytoalexin ; brassinin ; glucosinolate ; cabbage ; flowering ; juvenile traits ; genetic stability ; flow cytometry ; somaclonal variation ; thorniness ; carbohydrates ; protein ; lipids ; fatty acids ; minerals ; plastome ; Plicosepalus acaciae ; Plicosepalus curviflorus ; loranthaceae ; mistletoe ; phylogenetic relationship ; plastome structure ; comparative analysis ; magnetic resonance imaging ; Solanum tuberosum ; multi-exponential transverse relaxation ; water stress ; broccoli ; human nutrition ; improved health ; melatonin ; postharvest ; apricot ; pollen tube ; pollination ; Prunus armeniaca ; S-alleles ; Populus ; hexokinase ; sucrose metabolism ; sugar signaling ; stress and defense ; centres of origin ; crop wild relatives ; crop domestication ; cryopreservation ; conservation ; in vitro storage ; ecosystem restoration ; plant breeding ; acidification ; alkalinisation ; bud burst ; freezing ; Malus domestica ; pH ; Picea abies ; Pinus cembra ; histone modification ; Taraxacum kok-saghyz ; natural rubber ; high light stress ; singlet oxygen ; signalling ; GPX5 ; beta cyclocitral ; acrolein ; glutathione peroxidase ; carbonyl ; transcription ; SLIM1 transcription factor ; sulfur deficiency ; Arabidopsis thaliana ; sulfate transporter ; sulfate assimilation ; stress tolerance ; LRR-RLK receptors ; dodders ; parasitic plants ; proteomics ; virus vertical transmission ; CMV-Fny strain ; pseudorecombinant virus ; chimeric virus ; infection rate ; seed-growth tests ; electron microscopy ; circular dichroism spectroscopy ; viral assembly ; Adiantetea capilli-veneris ; demographic analysis ; ecology ; IUCN ; plant conservation ; phytosociology ; rupicolous habitat ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Asthma is a prevalent chronic inflammatory disease of the airways with complex etiology and mechanistic pathways and variable clinical presentation. Such heterogeneity renders the search for targeted therapies difficult. Currently, the best-known disease phenotype with tailored biological treatment is eosinophilic asthma; however, even in some of these patients, anti-IL5 treatment is ineffective. Furthermore, about a quarter of patients, especially those with a severe phenotype, develop progressive and irreversible airway obstruction, leading to persistent symptoms despite optimized treatment. Therefore, new therapeutic approaches are still needed, particularly in severe asthma. The Special Issue presents asthma research focusing on modern personalized therapeutic approaches. Particular interest is directed to novel asthma biomarkers, including molecular and epigenetic ones, shining new light on pathogenesis, phenotyping, and customized therapy in various airway inflammatory patterns of the disease. In addition, research articles on airway epithelial cell dysfunction, airway remodeling, and the overlap between asthma and chronic obstructive pulmonary disease are welcomed. Stanislawa Bazan-Socha (Guest Editors)
    Keywords: bronchial epithelial cells ; extracellular vesicles ; miRNAs ; airway epithelium ; asthma ; cellular compartmentalization ; allergic rhinitis ; allergen immunotherapy ; bronchial asthma ; component-resolved diagnosis ; sublingual immunotherapy ; fungal sensitization ; IL-17A ; Candida albicans ; mediation effect ; oxidative stress ; CBA assay ; airway remodeling ; severe asthma ; bronchial fibroblasts ; fibrosis ; Bcl10 ; NF-κB pathway ; cytokines ; efficacy ; investigational ; Phase I ; Phase II ; RCT ; allergy ; eosinophils ; immune health ; natural therapeutics ; prostacyclin ; allergic inflammation ; proinflammatory ; anti-inflammatory ; BLT2 ; G-CSF ; 12-LO ; neutrophil ; airway inflammation ; n/a ; miRNA ; children ; serum ; exhaled breath condensate ; diagnosis ; exacerbation ; biomarkers ; factors ; bic Book Industry Communication::M Medicine
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  • 84
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The Special Issue “Marine Anti-Inflammatory and Antioxidants Agents 2.0” collects in vitro and/or in vivo experimental investigations highlighting the role of marine-derived bioactive compounds as modulators of inflammation and/or oxidative stress, papers describing the mechanisms of action and molecular interactions of compounds isolated from marine organisms, and comprehensive review articles summarizing knowledge on marine anti-inflammatory and/or antioxidant agents in support of human health.
    Keywords: nanoselenium ; chondroitin sulfate derived from shark cartilage ; structure characterization ; antioxidant activity ; brown seaweed extract ; metabolic and inflammatory markers ; prediabetes ; deep-sea fungus ; A. unguis ; variotin ; coniosulfide ; anti-inflammatory ; antioxidant enzymes ; DNA damage ; ischemia and reperfusion ; lipid peroxidation ; lipid-soluble carotenoid ; neuroprotection ; functional foods ; health benefits ; seaweeds ; secondary metabolites ; functional feeds ; protein hydrolysate ; innate immunity ; fish robustness ; Posidonia oceanica ; AGEs ; marine antioxidants ; oxidative stress ; intestinal glucose uptake ; intestinal barrier integrity ; seaweed ; metabolic syndrome ; sulfated polysaccharide ; anti-inflammation ; cholesterol ; Ulva ; microbiome ; anti-inflammatory activity ; inflammatory pathways ; marine drugs ; echinoderm ; sea cucumber ; sea urchin ; starfish ; cadmium ; oyster protein hydrolysate ; hepatic injury ; inflammatory response ; hepatocyte apoptosis ; n/a ; bic Book Industry Communication::M Medicine
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  • 85
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: Optic neuropathies are conditions in which there is damage to the optic nerve (ON) caused by a variety of causes, including glaucoma, inflammation, gene abnormalities, ischemia, trauma, and toxicity. ON damage triggers a process of axon degeneration, inflammatory cytokine upregulation, breakdown of the blood–optic nerve barrier, and, eventually, the induction of apoptosis of retinal ganglion cells (RGCs), resulting in optic atrophy. To date, there is no effective treatment for most optic neuropathies; however, because the damage initially is axogenic, there may exist a window of therapeutic opportunity before the death of RGCs. Thus, the search for effective treatments for various optic neuropathies before there is permanent damage to prevent or limit visual dysfunction and the development of methods to stimulate axon and/or RGC regeneration to restore vision after damage has occurred is pivotal.This reprint collected 19 articles published in this Special Issue of IJMS which covers the molecular mechanisms to protect RGCs and/or axonal damage, translational research, gene therapy, regenerative medicine, and neuroprotection for glaucoma.
    Keywords: neuroprotection ; retinal ganglion cells ; optic neuropathy ; glaucoma ; pattern electroretinogram ; NMO ; astrocytes ; apoptosis ; BID ; inflammation ; neuroimmunology ; erythropoietin ; retinal ganglion cell ; optic nerve protection ; neuromyelitis optica spectrum disease ; aquaporin-4 ; myelin oligodendrocyte glycoprotein ; ocular coherence tomography ; complement ; microcystic macular degeneration ; Müller cell ; astrocyte ; oligodendrocyte ; microglia ; optic nerve head ; lamina cribrosa ; lamina cribrosa cells ; scleral fibroblasts ; glial cells ; intraocular pressure ; rat anterior ischemic optic neuropathy model ; retinal ganglion cell death ; TBP associated factor 9 ; TP53 regulated inhibitor of apoptosis 1 ; transcriptome ; optic nerve ; epigenetics ; myelin ; regeneration ; oligodendrocytes ; atypical optic neuritis treatment ; typical optic neuritis ; MOG ; MS prevention ; retina ; transcription ; CNS repair ; oncomodulin ; myeloid cells ; glaucomatous optic neuropathy ; fibrosis ; miR-29 ; extracellular matrix ; optic nerve crush ; azithromycin ; NAION ; neural injury ; neural ischemia ; neural inflammation ; Leber’s hereditary optic neuropathy ; LHON ; whole exome sequencing ; nuclear modifier genes ; leber’s hereditary optic neuropathy ; mitochondrial disorder ; mitochondrial optic neuropathy ; hereditary optic neuropathy ; neuro-ophthalmology ; idebenone ; nonarteritic anterior ischemic optic neuropathy ; rodents ; gene expression ; models ; diabetes ; ischemic optic neuropathy ; pioglitazone ; HSF1 ; Klf4 ; Oct4 ; Sox2 ; Yamanaka factors ; optic nerve regeneration ; zebrafish ; oligodendrocyte precursor cells ; secondary degeneration ; oxidative stress ; DNA damage ; proliferation ; blood-brain barrier ; CNS injury ; optic nerve injury ; synaptamide ; A8 ; axonal degeneration ; neuronal survival ; visual evoked potential ; n/a ; bic Book Industry Communication::M Medicine
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: This reprint, edited by Prof. Gaetano Santulli, MD, PhD, collects the most up-to-date peer-reviewed scientific papers dealing with cardiovascular medicine, from basic science to pre-clinical and clinical investigations, highlighting the fundamental importance of translational medicine in the challenging quest for new therapies to cure cardiovascular disease. Indeed, cardiovascular disease is the leading cause of death worldwide, and the search for novel mechanisms and therapeutics is desperately needed. Therefore, both basic and translational studies in the cardiovascular field represent a paramount strategy to identify novel therapeutic targets and improve the quality of life of patients with cardiovascular disorders.
    Keywords: cardiovascular disease ; vaccine ; clinical trials ; translational medicine ; atherosclerosis ; oxLDL ; phosphorylcholine ; RBP-4 ; insulin resistance ; severity of CAD ; T2D ; atherosclerotic CAD ; endothelial dysfunction ; hypoxia ; HIF-1α ; mitochondria ; oxidative stress ; inflammation ; cardiovascular diseases ; cancer ; therapeutic target ; extracellular NAD+ metabolism ; extracellular NMN metabolism ; vascular endothelial cells ; CD38 ; CD73 ; myocardial infarction ; neuregulin ; glial growth factor 2 ; pre-clinical therapy ; skeletal muscle ; gene expression ; RNA sequencing ; inflammatory bowel disease ; limb ischemia ; endothelial function ; ROS ; acute myocardial infarction ; diabetes ; lactic acid ; carbonic anhydrase ; CD34 ; endothelial cells ; ERG ; hypothermic oxygenated perfusion ; liver transplantation ; machine perfusion ; nestin ; VEGFR ; IDH1 ; foam cell ; macrophage ; ferroptosis ; NRF2 ; atrial fibrillation ; obesity ; immune infiltration ; biomarkers ; cardiac fibrosis ; lncRNAs ; TGF-β ; ECMs ; exosome ; red blood cells ; chemotherapy ; anemia ; microcirculation ; laser diffraction ; osmotic fragility test ; microfluidics ; valvular heart disease ; degenerative aortic valve stenosis ; irisin ; periostin ; osteoglycin ; IL-18 ; HMGB-1 ; PCSK9 ; blood–brain barrier ; blood pressure ; cerebrovascular disease ; hBMECs ; hypertension ; HUVEC ; microRNA ; miRNA ; miR-4432-3p ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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  • 87
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: The aim of this Special Issue is to collect reports regarding all the recent strategies, directed at the improvement of antineoplastic activity of drugs in cancer progression, engaging all the expertise needed for the development of new anticancer drugs: medicinal chemistry, pharmacology, molecular biology, and computational and drug delivery studies.
    Keywords: EGR-1 ; flavonoid ; (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile ; MDA-MB-231 ; MMP9 ; TNFα ; pancreatic ductal adenocarcinoma ; cyclodextrin inclusion complex ; phase solubility studies ; preformulation studies ; biphenylnicotinamide derivatives ; dual inhibitor ; EGFR ; VEGFR2 ; ligand-based pharmacophore ; molecular docking ; molecular dynamics ; leukemias ; doxorubicin ; inflammation ; drug delivery ; tumor targeting ; elastin-like polypeptide ; cell penetrating peptide ; matrix metalloproteinase ; doxorubicin resistance ; photosensitizer delivery system ; PAMAM dendrimer ; photodynamic therapy ; cytotoxicity ; phototoxicity ; colorectal adenocarcinoma ; dicarboximides ; chemical synthesis ; apoptosis ; kinases ; anticancer ; gene profiling ; SAR ; biomarkers ; colorectal cancer ; early detection examination ; liquid biopsy ; personalized medicine ; tumor treatment ; exosomes ; ctDNA ; CTC ; cytotoxic activity ; pyrazole derivatives ; MTT assay ; ADMET analysis ; single-crystal diffraction ; FTIR spectroscopy ; NMR spectroscopy thermogravimetric analysis ; acute myelogenous leukemia ; platelets ; microparticles ; γδ T cells ; immunotherapy ; tumor resistance ; combination therapy ; tumor microenvironment ; immune checkpoint inhibitor ; neuroblastoma ; molecular iodine ; cyclophosphamide ; xenografts ; metronomic therapy ; tamoxifen ; CYP2D6 ; MCF-7 ; Ishikawa cells ; SERM ; TNBC ; uterotrophic ; α-mangostin ; poly(amidoamine) dendrimer ; targeted drug delivery ; biotin targeting ; glioblastoma multiforme ; squamous cell carcinoma ; antiparasitic therapy ; diclofenac ; indomethacin ; oleanolic acid derivative conjugates ; NF-κB ; Nrf2 ; MAPKs ; PSN-1 cells ; reactive oxygen species ; glioblastoma ; brain tumor ; extracellular vesicles ; pancreatic cancer ; paclitaxel ; clathrin ; endocytosis ; sulforaphane ; nicotine ; metalloproteinase-9 ; gastric cancer ; cell invasion ; Arylquin 1 ; colon cancer ; tumor progression ; azelastine ; oxidative stress ; autophagy ; mitotic catastrophe ; chronic myeloid leukemia ; imatinib ; tyrosine kinase ; ketoconazole ; P-glycoprotein ; drug efflux transporter ; non-small-cell lung cancer ; cisplatin resistance ; aldehyde dehydrogenase ; isothiocyanates ; disulfiram ; epithelial to mesenchymal transition ; aminopeptidase N ; acetamidophenones ; Schiff bases ; semicarbazones ; thiosemicarbazones ; inhibition of proliferation ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
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  • 88
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: It is widely accepted that antioxidants can help in disease prevention by effectively quenching free radicals or inhibiting damage caused by oxidative stress. However, the final fate of antioxidants in the gut, how antioxidant metabolites affect gut microbiota, and how gut microbiota affect the metabolism of antioxidants are not fully understood. This Special Issue collected the latest research findings and review articles, bringing together current research and critical thinking on the fate of phytochemical antioxidants in the gut and the role antioxidant gut metabolites play in reducing oxidative stress in various gut and metabolic diseases. Both in vitro and in vivo studies relating to any of the following topics will be considered: fate of antioxidants in the gut; antioxidative activities of phytochemicals in the digestive system; molecular mechanisms of phytochemical antioxidants in maintaining gut health; and interactions of antioxidant metabolites and gut microbiota.
    Keywords: anthocyanins ; berries ; polyphenols ; bioaccesibility ; differential pulse voltammetry ; first-pass metabolism ; HPLC-ESI-QTOF-MS ; apparent permeability ; oxidative stress ; inflammation ; antioxidant ; anthocyanin ; phenolic acid ; antioxidant capacity ; medium chain fatty acids ; short chain fatty acids ; gut microbiome ; Ougan (Citrus reticulata cv. Suavissima) ; polymethoxyflavones ; gut microbiota ; metabolism in vivo ; metabolite identification ; beneficial regulatory effect ; Dendropanax morbifera ; hepatoprotective ; leaf extract ; liver damage ; alcoholism ; oxidative damage ; dietary polyphenols ; metabolites ; epigenetics ; microflora ; cardiometabolic complications ; selenium ; zinc ; bioaccumulation ; antioxidant capacities ; intestinal microbiota ; inhibition ; metabolism ; catabolism ; biotransformation ; bioactive compounds ; health ; diversity ; dysbiosis ; leaky gut ; endotoxemia ; fatty liver disease ; ethanol ; phytochemicals ; quercetin ; high-fat diet ; insulin resistance ; Bacillus amyloliquefaciens SC06 ; IPEC-J2 ; autophagy ; apoptosis ; AKT–FOXO ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
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  • 89
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The book is a reprint of a Special Issue with the same title published online in the chemical journal Molecules (ISSN 1420-3049) within the section of Medicinal Chemistry. It was edited by academic guest editors from September 2020 to April 2022. In total, it includes eighteen research/review articles including the editorial.
    Keywords: oxygen detection ; dendrogram analysis ; hierarchical clustering ; cancer cells ; luminescence lifetime ; hydrogen peroxide ; oxidative stress ; photodynamic therapy ; time-resolved imaging ; breast cancer ; NRF2 ; polyphenols ; melatonin ; acute myeloid leukemia (AML) ; metformin ; MCL-1 inhibitor S63845 ; reactive oxygen species (ROS) ; AQP3 ; AQP5 ; Anneslea fragrans ; antioxidant ; guided isolation ; flavonoid glycosides ; spheroids ; HT29 cells ; cluster analysis ; principal component analysis ; hydrolysable tannins ; HHDP-digalloylglucose isomer ; dihydroxyphenyl-γ-valerolactone ; autophagy ; colorectal cancer cells ; reactive oxygen species ; endoplasmic reticulum stress ; pentoxifylline ; astaxanthin ; particle encapsulation ; ionizing radiations ; macrophages ; radiation-induced fibrosis ; Rhopilema nomadica ; apoptosis ; cell cycle arrest ; HepG2 ; soybean ; peptides ; antioxidant capacity ; magnetite nanoparticles ; conjugation ; multicomponent reaction ; copper complexes ; glutathione depletion ; cysteine ; Casiopeina ; intermediate ; copper reduction ; papaverine ; cancer ; morphology ; proliferation ; cell cycle ; chain-transfer agent ; chemotherapy ; free radical chain reaction ; lipid peroxidation ; lipophilic thiol ; oxidative cell death ; prooxidative drug ; radical propagation ; rate-limiting step ; mitochondria ; bioenergetics ; anticancer ; cheminformatics ; in silico ; Keap1 ; molecular docking ; molecular dynamics ; myeloperoxidase ; NADPH oxidase ; seed antioxidant peptide ; xanthine oxidase ; osteosarcoma ; naringenin ; ROS ; ER stress ; ferroptosis ; inducers ; inhibitors ; drug-likeness ; neurodegenerative ; polyphenol ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 90
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: This book focuses on how nanoscale systems can be used to deliver molecules to help with cancer management. It provides a broad overview of some of the key strategies for nanocarrier design. These strategies are brought together by the wide compositional variety of these systems and the diversity of molecules that may be carried. Additionally, functionalization strategies, codelivery, and combination with other treatment modalities highlight a very active research field.
    Keywords: nanostructured lipid carriers ; doxorubicin ; mucositis ; cell internalization ; albumin ; BSA ; CPP ; gold nanorods ; gold nanoprisms ; arginine-rich peptide ; glutathione ; nanoparticles ; oxidative stress ; breast cancer ; gastric cancer ; nanoparticle ; fucoidan ; d-alpha-tocopherylpoly (ethylene glycol) succinate ; combination chemotherapy ; G-quadruplex ; nucleolin ; DNA nanocages ; intracellular localization ; cancer targeting ; molecular dynamics simulations ; mesoporous silica nanoparticles ; radiotherapy ; immunotherapy ; tumor microenvironment ; abscopal effect ; magnetofection in vivo ; magnetic nanoparticles ; iron oxide ; gene delivery ; gene vectors ; codelivery nanocarriers ; photodynamic therapy ; anticancer therapies ; combination therapy ; phthalocyanine ; uterine cervical neoplasms ; photochemotherapy ; in vitro ; in vivo ; nanocarrier ; polyplexes ; siRNA delivery ; glioblastoma therapy ; amphiphilic poly(α)glutamate ; P-selectin ; prodrug ; drug delivery ; targeted therapy ; chemotherapy ; prostate cancer ; prostate-specific membrane antigen ; targeted delivery ; encapsulation ; cabazitaxel ; nanocarriers ; nanosystems ; radiosensitizer ; hypoxia ; synergism ; cancer ; photothermal therapy ; combined antitumor effect ; oxygenation ; hydrogel ; hypoxic tumor ; n/a ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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  • 91
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: In this Special Issue, "Pathogenesis of Pregnancy-Related Complications", 4 reviews, 13 original papers, 1 communication, and 1 case report are compiled. These papers were published by scientific teams from 24 countries, including China, Tunisia, Canada, France, Serbia, Portugal, Spain, Chile, Singapore, Australia, the USA, Mexico, the Czech Republic, Germany, Sweden, Finland, the United Kingdom, Norway, Poland, Greece, Japan, Italy, Switzerland, and Israel, which is a really great achievement.
    Keywords: pregnancy-induced CVD ; chronic venous disease ; proinflammatory cytokines ; hypertensive vascular disorder ; MeSH ; preeclampsia ; MenSCs ; trophoblast invasion ; galectin ; maternal–fetal interface ; pathologic pregnancy ; gestational diabetes mellitus ; fetal growth restriction ; preterm birth ; FGF2 ; angiogenesis ; oxidative stress ; L-NAME ; gene expression ; placenta ; cardiovascular microRNAs ; early pregnancy ; prediction ; screening ; whole peripheral venous blood ; chorionic villus sampling ; congenital malformations ; prenatal testing transcriptome sequencing ; endometriosis ; pyroptosis ; PGE2 ; cell migration ; glucose uptake ; SLC2A3 ; SLC2A1 ; insulin ; glucagon ; infertility ; assisted reproductive technology ; implantation failure ; endometrium immunomodulation ; blood–brain barrier ; endothelium ; fetal hypoxia ; neuronal damage ; tight junctions ; tight junction proteins ; IL-6 ; IL-8 ; inflammation ; pregnancy ; pregnancy complications ; microRNAs ; miRNAs ; small RNA sequencing ; small RNA-seq ; sPTD ; miR-23b-5p ; miR-125a-5p ; miR-4732-5p ; primary hyperparathyroidism ; forensic ; pulmonary metastatic calcification ; B cells ; idiopathic recurrent pregnancy loss ; reproductive immunology ; meta-analysis ; ficolin-2 ; FCN2 ; newborn ; neonate ; prematurity ; single nucleotide polymorphism ; very low birthweight ; diabetes mellitus ; human ; RNA sequencing ; CD24 ; placental-derived immortalized cells ; JEG-3 cells ; BeWo cells ; STOX1-A/B ; in vitro preeclampsia models ; immune tolerance ; amino acid transporters ; SLC38A1 ; SLC38A2 ; SLC38A4 ; ischemic placental syndrome ; soluble endoglin (sEng) ; soluble fms-like tyrosine kinase-1 (sFlt-1) ; placental growth factor (PlGF) ; sFlt-1/PlGF and sFlt-1*sEng/PlGF ratios ; pregnancy adverse outcomes ; n/a ; bic Book Industry Communication::M Medicine
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  • 92
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Proteins and polysaccharides are two kinds of versatile natural macromolecules that are ubiquitous in nature. A tailored diet fortified with proteins and polysaccharides has been developed to ameliorate a wide array of diseases. This reprint contains experimental studies, reviews and systemic reviews that cover all beneficial aspects related to protein or polysaccharide fortification, especially for the treatment of various disorders and their complications.
    Keywords: water-insoluble β-glucan ; structure characterization ; physicochemical properties ; lipid metabolism ; low-protein diet ; nutritional status ; adult ; inherited metabolic disorders ; lactoferrin ; ferrous sulfate ; iron ; β-glucan ; doxorubicin cardiotoxicity ; heart failure ; oxidative stress ; hypertension ; plant protein ; animal protein ; total protein ; China Health and Nutrition Survey ; bone remodeling ; soy peptide CBP ; osteoblast ; differentiation ; p38-MAPK ; RUNX2 ; polysaccharide ; phytochemical ; ferroptosis ; liver injury ; protein–energy malnutrition ; global burden of disease ; prevalence ; death ; disability-adjusted life years ; anorexia ; physical function ; walking speed ; muscle strength ; dynapenia ; nutrition ; elderly ; diet ; egg protein ; malnutrition ; weight loss ; athletes ; sarcopenia ; brown adipose tissue ; visceral adipose tissue ; muscle mass ; brain natriuretic peptide ; breast milk ; bioactive protein ; proteomic analysis ; lactation periods ; burns ; carbohydrate–fat ratio ; enteral nutrition ; hypermetabolism ; organ damage ; blood pressure ; blood lipids ; cardiovascular disease ; casein hydrolysate ; n/a ; anti-aging ; mechanism ; Caenorhabditis elegans ; Drosophila melanogaster ; mice ; aging indicators ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC4 Cultural studies: food and society
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This reprint describes the ability of some foods or natural substances extracted by plants to counteract some of the most common diseases at present, such as obesity, diabetes, intestinal inflammatory diseases, and neurodegeneration. It is well accepted that high-fat diets that are rich in saturated fats are involved in the onset and progression of obesity and its dangerous comorbidities. It is also well accepted that a balanced diet is useful to maintain a good health status and the choice of certain foods could help to counteract the onset of chronic diseases. Foods and natural substances rich in compounds with anti-inflammatory and antioxidant properties should be paid attention. Most of these foods belong to the Mediterranean Diet, and they are famous for being rich of unsaturated fatty acids, such as the oleic acid found in extra-virgin olive oil, or the omega 3 contained in fish, vitamin D and vitamin C with their high anti-oxidant capacity, and spices and nuts that can counteract inflammatory status. These substances have also anti-obesity properties, because they are able to reduce fat mass and and restore the physiological role of fat tissue. Therefore, strict adherence to this healthy diet could be enough to prevent the onset of chronic diseases linked to fatty diets or aging. The scientific data collected in this reprint could provide new insights, allowing for readers to change their own dietary habits and make more informed food choices.
    Keywords: Alzheimer’s disease ; amyloid-β peptide ; oxidative stress ; inflammation ; nobiletin ; shea nut oil ; lipids ; triterpenes ; osteoarthritis ; pain ; hyaluronic acid ; cartilage ; FlexPro MD ; krill oil ; astaxanthin ; docosahexaenoic acid ; eicosapentaenoic acid ; functional food ; gout ; human health ; hyperuricemia ; PUFA ; SLC22A12 ; transporter ; uric acid ; uricosuric activity ; axillary osmidrosis treatment ; bioactivity investigation of food extract ; body odor ; food ingredient ; Glycine max ; health promotion ; MRP8 ; phytochemicals ; antioxidants ; Chlorella ; dietary fibers ; dietary supplements ; folate ; lutein ; vitamin B12 ; vitamin D2 ; Phaseolus multiflorus var. albus Bailey (PM) ; Pleurotus eryngii var. ferulae (PF) ; anti-obesity ; pancreatic lipase ; α-amylase ; macroalgae ; bioactive compounds ; bioactivities ; antimicrobial ; antiproliferative activity ; polysaccharides ; Euglena gracilis ; paramylon ; autonomic nervous system ; Aphanizomenon flos-aquae ; blue-green algae ; inflammatory bowel disease ; myopia ; lactoferrin ; IL-6 ; MMP-2 ; collagen ; gastric inflammation ; ethnopharmacology ; Cameroonian plants ; interleukin 8 ; interleukin 6 ; NF-κB ; COX-2 ; antioxidant ; metabolic syndrome ; Gum Arabic ; Acacia senegal ; Acacia seyal ; Garcinia cambogia ; nutritional supplements ; weight loss ; hepatotoxicity ; serotonin toxicity ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC4 Cultural studies: food and society
    Language: English
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Plant-derived phenolic compounds whose most important classes are flavonoids (i.e., catechin, epicatechin) quinones, stilbenes (i.e., resveratrol) and essential oils (i.e., thymol, carvacrol), widely found in fruits, seeds, flowers, and leaves, are considered as beneficial molecules for prevention and treatment of several diseases, since it has been shown that they have antioxidant, anticarcinogenic, cardioprotective, neuroprotective, and anti-inflammatory properties. The Special Issue contains contributions concerning different aspects of the use of phenolic plant-derived molecules for prevention and therapy of several diseases, in order to understand the mechanisms involved in their protective role, their bioavailability and their metabolism in human tissue. Moreover, the use of different strategies for extraction, synthesis, and delivery of these compounds, has been covered.
    Keywords: Allium subhirsutum L. ; wound-healing activity ; antioxidant potential ; inflammatory marker ; oxidative stress ; caffeic acid ; metabolic syndrome ; phenolic compound ; obesity ; dyslipidemia ; hyperglycemia ; hypertension ; curcumin ; GSK-3β ; inflammation ; DNA damage ; polyphenolic compounds ; quercetin ; hematological disorders ; anti-proliferative effect ; apoptosis ; autophagy ; epigenetic modifications ; procyanidin B1 ; mouse ; SCNT ; embryo ; reactive oxygen species ; resveratrol ; Bax ; Bcl-2 ; Caspase-3 ; multidrug resistance ; pancreatic cancer ; solid lipid nanoparticles ; grape seed–derived extract ; drug delivery ; X-ray diffraction ; antioxidant activity ; fish cells ; hepato-nephrotoxicity ; HPLC analysis ; O. stricta ; testicular damage ; n/a ; saffron petal extracts ; antifungal effect ; postharvest diseases ; biochemical analysis ; GC-MS ; FT-IR ; bioactive compounds ; antioxidants ; agricultural residues ; fruits ; vegetables ; mass spectrometry ; extraction ; catechin ; dimyristoylphosphatidylglycerol ; DSC ; FTIR ; molecular dynamics ; Paralepista flaccida ; Lepista nuda ; biomolecules ; Moroccan mushroom ; wild edible mushroom ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 95
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Halophytes are a fascinating group of wild plants adapted to highly saline natural habitats, where most plant species and all our conventional crops would not survive. In fact, some halophytes can withstand even seawater salinity. In the current climate change scenario, increasing average temperatures and drought episodes contribute to the accelerated salinisation of irrigated cropland, especially in arid and semiarid regions, by the progressive accumulation in the soil of salts dissolved in irrigation water. This ‘secondary salinisation’ is one of the major causes of reducing crop yields worldwide. In this context, halophytes represent ideal experimental systems to investigate the mechanisms plants use to respond to high-salinity conditions. This knowledge will be essential for the genetic improvement of crop salt tolerance, which represents the most sensible strategy to address the abovementioned problem. Furthermore, halophytes could be the basis of a sustainable, ‘saline’ agriculture, after domestication and some breeding to improve agronomic characteristics. Then, they could be commercially cultivated for food, feed, fibre, or the production of biomolecules of industrial interest. Since they could be grown in saline land and irrigated with brackish water, they will not compete with our conventional crops for these limited resources, fertile land and good-quality water for irrigation. The articles included in this Special Issue address these different aspects of halophytes’ research, although most focus on basic studies on salt-tolerance mechanisms.
    Keywords: halophytes ; Amaranthaceae ; salinity ; antioxidant enzymes ; phenolic compounds ; salt stress ; growth responses ; ion accumulation ; osmolytes ; oxidative stress biomarkers ; antioxidants ; climate change ; growth ; osmolyte accumulation ; phytohormones ; polyamines ; salicylic acid ; biosaline agriculture ; salt tolerance ; osmotic stress ; pre-conditioning ; intraspecific variability ; bioactive compounds ; flavonoids ; fatty acids ; Suaeda ; physiology ; oxidative stress ; potential toxic elements ; betacyanin ; carbon ; nitrogen ; phytoremediation ; rice ; halophyte ; root ; microelectrode ion flux ; MIFE ; transporters ; inflorescences ; ion localization ; forage legumes ; ions ; mineral nutrition ; salinity tolerance ; strawberry clover ; morphology ; anatomy ; catalase ; peroxidase ; hydrogen peroxide ; chlorophyll content ; Sarcocornia fruticosa ; Salicornia europaea ; Salicornia veneta ; drought stress ; stress recovery ; ion transport ; oxidative stress markers ; salt glands ; recretohalophytes ; endemism ; water deficit ; osmolytes accumulation ; drought tolerance ; conservation programmes ; climate emergency ; crops’ wild relatives ; glycophytes ; salt tolerance mechanisms ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PST Botany & plant sciences
    Language: English
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  • 96
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: A major task for health professionals and health systems is effectively preventing and treating cardiovascular and metabolic diseases. This reprint offers an updated set of experimental and clinical information on the usefulness of nutraceutical products for the management of cardiometabolic diseases, which range from obesity and diabetes mellitus and their complications to hypercholesterolemia. The nutraceutical option may be used according the “beyond diet, before drug” strategy and is particularly relevant in the cardiometabolic field. The chapters of this reprint offer a deep insight into relevant issues in this nutraceutical field, such as experimental research for the preclinical identification of interesting compounds of natural origin, quality of nutraceutical products and their efficacy and safety, regulatory aspects, and the quality of evidence-based medicine.
    Keywords: Atherosclerotic Cardiovascular Diseases ; Gut Microbiota ; next generation sequencing ; oxysterols ; 24-OHC ; 25-OHC ; 27-OHC ; cholesterol metabolism ; probiotic ; cardiovascular risk ; hypercholesterolemia ; monacolin K ; nutraceutical ; very-low calorie ketogenic diet ; obesity ; insulin resistance ; diabetic retinopathy ; macular xanthophylls ; carotenoids ; macular pigment ; macular pigment optical density ; MPOD ; lutein ; zeaxanthin ; meso-zeaxanthin ; diabetes ; retinal neurodegeneration ; neuroprotection ; phytosterols ; plant sterols ; cholesterol ; cardiovascular disease ; supplements ; functional foods ; PREDIMED ; Mediterranean diet ; lipid profile ; polyphenols ; menopause ; body fat ; biomarkers ; tartaric acid ; nutraceuticals ; dyslipidaemia ; atherosclerosis ; tree nuts ; peanuts ; fatty acids ; prospective studies ; randomized clinical trials ; type-2 diabetes ; cancer ; hypertension ; cognitive function ; mortality ; body weight ; blood lipids ; inflammation ; dietary lipids ; immune-inflammation ; microbiota ; Cameroonian spice extracts ; SW 872 adipocytes ; triglyceride accumulation ; glucose uptake ; oxidative stress ; pro-inflammatory cytokines ; Prunus domestica L. ; chemical characterization ; digestive enzyme inhibition ; HMG-CoA reductase inhibition ; anti-inflammatory activity ; guidelines ; nutraceutical product ; metabolic disease ; type 2 diabetes mellitus ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
    Language: English
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  • 97
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Autophagy is a conserved degradative mechanism essential for cellular homeostasis in eukaryotic organisms. It is a cellular response mechanism that helps cells adapt and survive under various stressful conditions. It involves the degradation and recycling of cellular components to maintain cellular homeostasis and protect against damage from stressors like nutrient deprivation, oxidative stress, infection, and protein misfolding. However, the understanding of the molecular mechanisms of autophagy regulation is still in significant development, including the involvement of gasotransmitters and small signaling molecules, such as those produced under ROS, RNS and RSS. Dysregulation of autophagy has been implicated in various diseases, making it an important area of research to improve biomedical therapies and strategies for overcoming the challenges from environmental stresses. Therefore, this Special Issue aims to review the current developments regarding autophagy research.
    Keywords: mitophagy ; aging ; Reactive Oxygen Species ; PINK1 ; mitochondria ; Alzheimer ; Parkinson ; melatonin ; metabolic syndrome ; autophagy ; lipophagy ; Harderian gland ; degradation ; vacuole ; autophagosomes ; autophagy-related protein ; energy stress ; ER stress ; nutrient stress ; oxidative stress ; regulation ; autophagy-related genes (ATG) ; hydrogen sulfide ; persulfidation ; OXPHOS ; mitochondrial diseases ; Harlequin ; heart ; skeletal muscle ; cerebellum ; brain ; ULK1 ; CHK2 ; ROS ; mTOR ; AMD ; DR ; glaucoma ; hypoxia ; inflammation ; rapamycin ; clinical trial ; intestinal homeostasis ; colorectal cancer ; stress response ; GPCR ; Gq ; mechanotransduction ; extracellular matrix ; non-alcoholic fatty liver disease ; stevia ; stevioside ; PPARα ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Language: English
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  • 98
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint represents a collection of papers that aimed to highlight the importance of immunohistochemical findings and their role in improving the understanding of organ tissue functions. We focused our attention on farm animals because they represent not only a source of food in the supply chain, but also a source of income for breeders, a source of employment, and a primary tool in the quest for sustainable food production. To achieve this last aim, we asked authors for research that could potentially be applied to the purpose of this study, and whose results could be useful in improving farm management practices and the responsible use of natural resources. A total of 20 papers were contributed to this issue, written by 118 authors from 4 countries, and comprising 18 research articles and 2 communications articles.
    Keywords: yak ; ERK1/2 ; ovary ; oviduct ; uterus ; NF-κB ; mitochondria ; oxidative stress ; back-fat ; placenta ; pig ; acrylamide ; stomach ; enteric nervous system ; CART ; VAChT ; nNOS ; domestic turkey ; pineal ; melatonin ; plasma ; rhythm ; intestine ; epithelium ; folds ; renewal ; rainbow trout ; inflammation ; sympathetic innervation ; caudal mesenteric ganglion ; chemical plasticity ; gilt ; mandibular gland ; feed physical form ; apelin ; aquaporin 5 ; complex carbohydrates ; 3,5-diiodo-L-thyronine ; zebrafish ; diet-induced obesity ; intestinal inflammation ; brain inflammation ; immunohistochemical analysis ; RT-PCR ; IGFs ; GSH ; CYP1A ; Dicentrarchus labrax ; organic aquaculture ; SARS-CoV-2 ; ACE2 ; lagomorphs ; virus–receptor complex ; in silico ; RIA ; PAG ; gestation ; sheep ; postpartum ; breed ; multiple pregnancy ; single pregnancy ; blood biochemistry ; performances ; rabbits ; semen quality ; thyme essential oil ; aging ; Mic60 ; OPA1 ; myocardial mitochondria ; Tibetan sheep ; horse ; squamous cell carcinoma of the larynx (SCCL) ; epithelial to mesenchymal transition (EMT) ; equine papillomavirus type 2 (EcPV2) ; CB1R ; CB2R ; TRPV1 ; TRPA1 ; 5-HT1aR ; endocannabinoid system ; immunohistochemistry ; gastro-intestinal apparatus ; feed additive ; small ruminants ; goats ; neuropeptides ; natural compound ; polyphenols ; embryonic mortality ; pregnancy-associated glycoproteins ; progesterone ; ultrasonography ; buffalo ; feed supplementation ; Ovis aries ; metabolic hormones ; BCS ; drought stress ; Italian Central Apennine ; marine collagen ; wound healing ; regenerative medicine ; innovative therapies ; skin substitute ; sea urchin ; biomaterials ; tissue engineering ; circular economy ; 3D scaffolds ; healthy reference individuals ; high-welfare farm ; metabolic profile ; subclinical disorders ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 99
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Polyphenols are natural phytochemicals recognized as one of the largest and most widespread classes of plant constituents occurring throughout the plant kingdom. Over the years, polyphenols have attracted the attention of the scientific community due to their potential health-promoting effects. Owing to their several interesting properties, polyphenols have aroused considerable interest, shedding light on their chemistry, reactivity, biological properties and their beneficial effects on both plants and humans. As a result of these investigations, a huge number of research works have been reported on polyphenols. However, despite the voluminous literature studying polyphenols and their impact on human health, there are still many issues waiting to be explored in order to explain and elucidate the positive effects of polyphenols on human health. This Special Issue was intended to gather up-to-date knowledge related to the cutting-edge research in the broad scientific area of polyphenols, providing an opportunity to show the latest advances in the exploration of polyphenols and their health beneficial effects. The special issue was a great success with more than 50 published manuscripts covering various aspects related to polyphenols and their role in human health. We are confident that this Special Issue will be of great interest to the scientific community, and will contribute to the improvement of knowledge regarding the area of polyphenols, leading to a better understanding of their role in human health.
    Keywords: polyphenolic curcumin ; cisplatin ; combination therapy ; breast cancer ; apoptosis ; gemini surfactant nanoparticles ; Mucuna pruriens seed ; neuroprotective activity ; Parkinson’s disease ; anti-acetylcholinesterase activity ; L-dopa ; Mitrephora sirikitiae ; anti-inflammation ; lignans ; polyphenols ; mRNA expression ; cytokines ; gemini curcumin ; colorectal cancer ; RNA sequencing ; PPI network ; differentially expressed genes ; Ericaceae ; LC–DAD/ESI–MS ; phenolic compounds ; flavonoids ; antioxidant activity ; Artemia salina Leach ; resveratrol ; hexavalent chromium ; 8-hydroxydeoxyguanosine adduct repair ; endogenous antioxidant system ; antigenotoxic ; Opuntia sp. ; prickly pear ; inflammation ; ginseng leaf ; far-infrared irradiation ; ginsenosides ; antioxidants ; health benefits ; polysaccharides ; freeze-drying ; spray-drying ; antidiabetic ; Averrhoa carambola L. ; dihydrochalcone ; flavone glycosides ; obesity ; Oxalidaceae ; type 2 diabetes ; Alchemilla viridiflora Rothm. ; SARS-CoV-2 ; COVID-19 ; spike glycoprotein ; neuropilin-1 ; in vitro ; in silico ; Origanum compactum ; HPLC-PDA-ESI/MS ; antibacterial activity ; bioactive compounds ; nutraceuticals ; phenols ; pomegranate peels ; phytochemical ; wistin ; NADES ; total polyphenolic content ; enzyme inhibition ; functional food ; natural medicine ; Alzheimer cholinesterase inhibitors ; Maqui ; platelets ; phenolic compounds and cardiovascular ; phenolic acids ; sinapic acid ; ACE inhibition ; hypertension ; endothelial dysfunction ; Graminex pollen ; hydroalcoholic extract ; oxidative stress ; gene expression ; TRPV1 ; pterostilbene ; antioxidant ; bioavailability ; cancer ; diabetes ; Nrf2 ; Rosmarinus officinalis ; chemical analysis ; glioblastoma ; rhabdomyosarcoma ; red onion ; phytochemicals ; H9c2 rat cardiomyoblast ; primary human fibroblasts ; blood disorder ; haemoglobin ; natural product ; nutraceutical ; nutritional disease ; lichens ; neuroprotection ; cetrarioid clade ; grape polyphenols ; sarcopenia ; skeletal muscle ; clinical trial ; R. conduplicans ; lichen ; secondary metabolites ; DNA damage ; α-glucosidase inhibition ; adlay ; adlay testa ; antiglycation ; phenolic acid ; grape pomace ; anti-inflammatory ; curcumin ; poly(glycerol sebacate) ; nanoparticles ; drug delivery system ; human cervical cancer ; baicalein ; mangiferin ; quercetin ; diabetes mellitus ; peripheral artery disease ; cardiovascular diseases ; Cyperus esculentus ; tiger nut ; metabolomics ; UHPLC-ESI-QTOF-MS/MS ; foodomics ; scopolamine ; memory impairments ; phenol compounds ; polydatin ; 3-O-β-d-resveratrol-glucopyranoside ; cervical cancer ; lung cancer ; ovarian cancer ; nanosuspension ; antioxidant properties ; LPS-induced inflammation ; NO-scavenging activity ; mountain tea ; Lamiaceae ; iridoids ; phenylethanoids ; ultrasound-assisted extraction ; melittoside ; ajugoside ; verbascoside ; ferulic acid ; apoptosis and cell cycle arrest ; anti-angiogenesis ; anti-metastasis ; synergism ; Cymbopogon schoenanthus ; hyaluronidase ; acetylcholinesterase ; neurodegeneration ; skin ; hair ; human health ; immobilized PTP1B ; drug screening ; cell surface display ; salvianolic acid B ; traditional Chinese medicine ; Salicornia ; extraction technologies ; agro-industrial by-products ; biological activity ; circular economy ; health effects ; re-integration ; waste management ; blood orange peels ; infrared-assisted extraction ; optimization ; Aflatoxin B1 ; Achillea millefolium ; bioaccessibility ; Caco-2 absorption ; in vitro digestion ; sterol regulatory element-binding protein 1 ; human oral squamous cell carcinoma ; autophagy ; epidermal fatty acid-binding protein ; lentil hull ; enzymatic hydrolysis ; microwave-assisted extraction ; oligosaccharides ; Alocasia gigantea ; hepatocellular carcinoma ; histopathology ; UHPLC–DAD–ESI–MS/MS ; Salvianolic acid B ; matrix metalloproteinase 9 ; gelatinase B ; MDA-MB-231 human breast cancer cells ; TIMP-1 ; agri-food wastes ; sustainability ; polyphenols bioavailability ; polyphenols activity ; cosmeceuticals ; nano-delivery ; health ; Lithocarpus litseifolius ; trilobatin ; phloridzin ; phloretin ; metabolic pathway ; bioactivity ; honey ; functional beverage ; characterization ; alcoholic beverage ; fermented beverage ; functional foods ; beneficial effects ; biological treatment ; bioreactors ; water ; aerobic granular sludge ; conventional active ted sludge ; biofilter ; photobioreactor ; membrane bioreactor ; bio-electrochemical systems ; chitosan ; Indian borage ; biotic elicitor ; insect-based foods ; Folin–Ciocalteu method ; phenols and flavonoids ; polyphenols bioactivity ; cereal ; pre-harvest sprouting ; antiradical capacity ; antitumor activity ; bee products ; phenylamides ; multivariate statistical analysis ; Juniperus sabina ; cupressuflavone ; intranasal ; pharmacokinetic ; motor coordination ; oregano ; box–behnken ; phenolics ; HPLC-PDA analysis ; UPLC-Q-TOF MS ; olive pomace ; PBMC ; immune gene expression ; HPLC-DAD ; metabolome ; phenolic bioaccessibility ; propolis ; total phenolic compounds ; antioxidant capacity ; UHPLC-DAD-ESI-MS ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences
    Language: English
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  • 100
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Humans have eaten nuts for thousands of years, yet their consumption was discouraged just a few decades ago due to their high-fat content. This perspective began to change in the early 1990s due to seminal publications from the Adventist Health Study, which showed that nut consumption significantly improved heart health-related outcomes. Many randomized clinical trials, epidemiological studies, and in vitro/in vivo mechanistic studies have since explored the role of eating nuts and its relation to health. Similarly, dried fruits have been scrutinized due to their concentrated sugar content despite their non-sodium micronutrient and fiber density. Due to accumulating evidence on nut and dried fruit intake and health outcomes, an international scientific meeting was organized for leading experts to examine and recapitulate in detail what is well known and established and what avenues of knowledge are still lacking in nut and dried fruit research. These findings highlight the beneficial health potentials of nuts for researchers, health professionals, other stakeholders, and the public while simultaneously pinpointing areas for further investigation to continue informing and guiding health practices and policies.
    Keywords: nuts ; cholesterol ; lipids ; apolipoproteins ; diabetes ; glycemic control ; insulin resistance ; tree nuts ; peanuts ; nutrition ; cardiovascular diseases ; review ; environment ; sustainability ; reproduction ; sexual function ; diet ; dietary patterns ; cognitive performance ; brain health ; dementia ; lifespan ; aging ; epidemiological studies ; clinical trials ; inflammation ; non-communicable diseases ; oxidative stress ; energy ; calories ; mastication ; appetite ; food intake ; body weight ; obesity ; dried fruits ; cancer ; cancer survivors ; mortality ; gut health and microbiome ; cardiometabolic diseases ; bone health ; dietary guidance ; n/a ; gut health ; microbiota ; digestion ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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