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  • thema EDItEUR::N History and Archaeology::NH History  (1,356)
  • bic Book Industry Communication::M Medicine  (987)
  • thema EDItEUR::N History and Archaeology::NH History::NHD European history  (733)
  • English  (2,930)
  • Dutch  (31)
  • Swedish  (20)
  • Russian  (12)
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  • 1
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    Language and Culture on the Margins (2024)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-01
    Description: This collection of thirteen essays examines sociolinguistic phenomena in a wide variety of marginal environments, providing both an overview of globalizaiton on the margins and a foundation for an expanded understanding of the processes of linguistic and cultural changes at work in these settings. Taking an expansive conceptual view of margins, the volume is organized in three parts, looking at examples of marginal spaces in the nation-state, in online environments, and in the peripheries of urban locations, globally to call attention to new and changing discursive genres, patterns, practices, and identities emerging in these spaces as a result of contemporary mobilities, the evolving global economy, and socio-political changes. With previous research previously confined to the study of globalization in urban areas, this volume opens the door for further research on the complex sociolinguistic processes resulting from globalization on the margins, making this an ideal resource for students and scholars in sociolinguistics, globalization and heritage studies, new media, anthropology, and cultural studies. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution (CC-BY)
    Keywords: Hoe Gaan Dit ; Linguistic Landscape ; Gregory Richardson ; Local Linguistic Landscape ; Xuan Wang ; Transcarpathian Oblast ; Massimiliano Spotti ; Dutch Caribbean Island ; Thayse Figueira Guimarães ; Smart Phones ; Branca Falabella Fabrício ; Sami Language ; Luiz Paulo Moita-Lopes ; Center Periphery Dynamics ; Paja Foudree ; Young Men ; Fie Velghe ; Language Ideologies ; Hirut Woldemariam ; Finnish Lapland ; Elizabeth Lanza ; Bongo Flava ; Binyam Sisay Mendisu ; Calypso Music ; Eleni Mariou ; Main Characters ; Zane Goebel ; Standard Ukrainian ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFD Psycholinguistics and cognitive linguistics::CFDM Bilingualism and multilingualism ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Language: English
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  • 2
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    Faithful Transgressions In The American West (2023)
    University Press of Colorado | Utah State University Press
    Details
    Publication Date: 2024-04-02
    Description: The central issue Bush finds in these works is how their authors have dealt with the authority of Mormon Church leaders. As she puts it in her preface, "I use the phrase 'faithful transgression' to describe moments in the texts when each writer, explicitly or implicitly, commits herself in writing to trust her own ideas and authority over official religious authority while also conceiving of and depicting herself to be a 'faithful' member of the Church." Bush recognizes her book as her own act of faithful transgression. Writing it involved wrestling, she states, "with my own deeply ingrained religious beliefs and my equally compelling education in feminist theories that mean to liberate and empower women." Faithful Transgressions examines a remarkable group of authors and their highly readable and entertaining books. In producing the first significant book-length study of Mormon women's autobiographical writing, Bush rides a wave of memoir publishing and academic interest in autobiography and other life narratives. As she elucidates these works in relation to the religious tradition that played a major role in shaping them, she not only positions them in relation to feminist theory and current work on women's life writings but ties them to the long literary tradition of spiritual autobiography.
    Keywords: History ; Religion ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups
    Language: English
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  • 3
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    The Changing Status of German Reunification in Western Diplomacy, 1955-1966 (2022)
    Johns Hopkins University Press
    Details
    Publication Date: 2024-04-02
    Description: This book reviews the course of NATO policy on German reunification from the perspective of West German preferences and Bonn's endeavors to have them respected in the diplomatic efforts of the major allies. With its accession to NATO, the West German government under Adenauer continued its policy of rehabilitating the German people in the eyes of the Western political community by playing a willing and sometimes leading role in joint ventures whose purpose was said to transcend the nation-state.
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 4
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    Words in Space and Time (2022)
    Central European University Press
    Details
    Publication Date: 2024-04-02
    Description: With forty-two extensively annotated maps, this atlas offers novel insights into the history and mechanics of how Central Europe’s languages have been made, unmade, and deployed for political action. The innovative combination of linguistics, history, and cartography makes a wealth of hard-to-reach knowledge readily available to both specialist and general readers. It combines information on languages, dialects, alphabets, religions, mass violence, or migrations over an extended period of time. The story first focuses on Central Europe’s dialect continua, the emergence of states, and the spread of writing technology from the tenth century onward. Most maps concentrate on the last two centuries. The main storyline opens with the emergence of the Western European concept of the nation, in accord with which the ethnolinguistic nation-states of Italy and Germany were founded. In the Central European view, a “proper” nation is none other than the speech community of a single language. The Atlas aspires to help users make the intellectual leap of perceiving languages as products of human history and part of culture. Like states, nations, universities, towns, associations, art, beauty, religions, injustice, or atheism—languages are artefacts invented and shaped by individuals and their groups.
    Keywords: Ethnolinguistics, Nation states, Language politics, Nationalism, Sociolinguistics, Areal linguistics ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology
    Language: English
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  • 5
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 6
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    Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
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    De la nordicité au boréalisme (2022)
    EPURE, Éditions et presses universitaires de Reims
    Details
    Publication Date: 2024-04-02
    Description: In recent years, through novels and television series ("Vikings", "Millennium", "Borgen" or "Occupied"), Nordic culture has become more visible internationally. At the same time, researchers are questioning what the North is, its conceptualisation, its cultural implications, its geographical characteristics, its social and political challenges. This volume is part of the current debate on the Nordic imaginary based on a notion, Nordicity, which intersects with borealism. Plural and mobile, the North inspires both scriptural and figurative production based on desire, dream, fascination or fantasy. The real, tangible and contingent North is only the apparent surface of a manufactured and invented North. How can we express northernness today? Is a theory of the North possible? This volume attempts to answer these questions by bringing together contributions from researchers in Nordic studies, literature, linguistics and the humanities: each is given the opportunity to define his own conception of Nordicity. Ces dernières années, à travers romans et sériés télévisées ("Vikings", "Millennium", "Borgen" ou "Occupied"), la culture nordique a gagné en visibilité internationale. Simultanément, les chercheurs s'interrogent sur ce qu’est le Nord, sa conceptualisation, ses implications culturelles, ses caractéristiques géographiques, ses enjeux sociaux et politiques. Ce volume s’insère dans le débat actuel sur l’imaginaire nordique à partir d’une notion – la nordicité – qui interagit tout particulièrement avec le boréalisme. Pluriel et mouvant, moteur constant de redéfinitions, le Nord inspire une fabrication tant scripturale que figurale fondée sur le désir, le rêve, la fascination ou le fantasme. Le Nord réel, tangible contingent, n’est que la surface apparente d’un Nord fabriqué et inventé. Comment dire aujourd’hui la nordicité? Une théorie du Nord est-elle possible? Ce volume s’attache à répondre à ces différentes questions en réunissant les contributions de chercheurs en études nordiques, littérature, linguistique ou sciences humaines: chacun dispose ici d’une carte blanche pour définir sa conception de la nordicité.
    Keywords: Nordicity ; Scandinavia ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::1 Place qualifiers::1D Europe::1DN Northern Europe, Scandinavia ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages::2AC Germanic and Scandinavian languages::2ACS Scandinavian languages ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages::2AC Germanic and Scandinavian languages::2ACB English::2ACBC Middle English
    Language: French , English
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  • 8
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    Chapter 1 Classical heritage and European identities (2021)
    Taylor & Francis | Classical Heritage and European Identities | Routledge
    Details
    Publication Date: 2024-04-01
    Description: This book examines how different agents and institutions within the Danish nation state have situated themselves within this complex landscape of competing appropriations of classical antiquity from the eighteenth century to the present day. In particular, it focuses on the use of classical heritages to construct both European and national identities (in the plural) and especially on how Danes in this period have engaged with a sense of European commonality through their engagements with the classical past.
    Keywords: Classical heritage ; European identities ; Europe ; Danish nation ; Denmark ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 9
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    Chapter 1 Dimensions of European heritage and memory (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-01
    Description: This book is a reflection on the politics of heritage in Europe at the present time, in a moment of pluralised conceptions of the political, social and demographic organisation proper to Europe. It is not a book that seeks to survey, define or characterise an enduring ‘European heritage’ as an entity, but rather to explore what heritage does – how it is understood, instrumentalised and what it enables – within what we will argue is a ‘critical’ moment for both identities and geopolitics in Europe.
    Keywords: European heritage ; political organisation ; social organisation ; demographic organisation ; Europe ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general
    Language: English
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  • 10
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    Chapter The Chapel of Sant’Agata in Pisa. 3D surveying, Artificial Intelligence and archival heritage (2022)
    FrancoAngeli
    Details
    Publication Date: 2024-04-04
    Description: The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences.
    Keywords: Discipline of representation, History, Semiotics, Science, Technology ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: Italian , English
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  • 11
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    Neuroimmune Interface in Health and Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
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    Printing and Prophecy (2021)
    University of Michigan Press | University of Michigan Press
    Details
    Publication Date: 2024-04-02
    Description: "Printing and Prophecy: Prognostication and Media Change 1450-1550 examines prognostic traditions and late medieval prophetic texts in the first century of printing and their effect on the new medium of print. The many prophetic and prognostic works that followed Europe's earliest known printed book—not the Gutenberg Bible, but the Sibyl's Prophecy, printed by Gutenberg two years earlier and known today only from a single page—over the next century were perennial best sellers for many printers, and they provide the modern observer with a unique way to study the history and inner workings of the print medium. The very popularity of these works, often published as affordable booklets, raised fears of social unrest. Printers therefore had to meet customer demand while at the same time channeling readers' reactions along approved paths. Authors were packaged—and packaged themselves—in word and image to respond to the tension, while leading figures of early modern culture such as Paracelsus, Martin Luther, and Sebastian Brant used printed prophecies for their own purposes in a rapidly changing society. Based on a wide reading of many sources, Printing and Prophecy contributes to the study of early modern literature, including how print changed the relationship among authors, readers, and texts. The prophetic and astrological texts the book examines document changes in early modern society that are particularly relevant to German studies and are key texts for understanding the development of science, religion, and popular culture in the early modern period. By combining the methods of cultural studies and book history, this volume brings a new perspective to the study of Gutenberg and later printers."
    Keywords: History ; Astrology ; Latin ; Lichtenberger ; Practica (astrology) ; Prophecy ; Woodcut ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 13
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    Inhibiting PARP as a Strategic Target in Cancer (2021)
    Frontiers Media SA
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    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 14
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    Associative Governance in Scandinavia (2024)
    Taylor & Francis | Routledge
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    Publication Date: 2024-04-07
    Description: This edited volume explores a variety of aspects of associative governance, providing detailed case studies of associations and associational governance in Scandinavia. Theoretically developing a concept and approach of associative governance, the book sheds light on a dynamic way of perceiving associative aspects of community and commercial life that has been hitherto underexplored and undertheorized. It shows how governance by associations may be conducted not only bottom‑up by self‑organized and voluntary participation, but also top‑down by authoritative incorporation through government, and – not least – in multifarious interstices in between. New section by exploring a vibrant panoply of dimensions of associative governance, empirically grounded in historical analyses of a wide range of organizational repertoires, the book may provide novel insights into the significant role of associative governance in Scandinavia over the past two centuries. Finally, it provides research‑based knowledge about how to maintain “good political and economic institutions” in the future and a more holistic and dynamic approach to the literature on The Nordic model. The book will be of key interest to scholars and students of Nordic and Scandinavian studies, history, sociology, political science, marketing, social policy, organization theory, and public management. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution‑Non Commercial‑No Derivatives (CC‑BY‑NC‑ND) 4.0 license.
    Keywords: Nordic societies ; Scandinavia ; governance ; Scandinavian societies ; Nordic governance ; associative governance ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTM Regional / International studies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJU Organizational theory and behaviour ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 15
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    Education and Sustainable Development Goals (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2024-04-02
    Description: This reprint addresses the relationship between education and sustainability from various perspectives. The main issues discussed in the 12 collected papers are concerned with (1) the quality of education, (2) SDG policy and implementation, (3) education and societal development, (4) students’ learning, and (5) global experience.
    Keywords: bridging academics ; regional sustainability ; knowledge diffusion ; public–private partnership ; multi-node knowledge link model ; stakeholders ; paradox of Chinese learners ; learning concept ; virtue model ; mind model ; Confucian culture ; mindset intervention ; interaction ; iterative process ; persuasive ; stealthy ; education for sustainable development ; China ; education policy ; sustainable development ; ESD ; SDGs ; sustainability ; higher education ; indicators ; rankings ; assessment ; university rankings ; green universities ; green campus ; education ; learning ; educational innovation ecosystem ; education sustainability ; university-industry collaboration ; Chinese higher education ; digital age ; talents cultivation ; information literacy ; online learning process ; innovation performance ; nature education ; urban residents ; perception ; survey ; sustainable growth ; social-emotional skills ; self-management skills ; solution-focused ; Kids’Skills method ; education partnership assistance ; common prosperity ; balanced and sustainable development ; capacity building ; professional learning communities in interdisciplinary subjects ; teachers’ professional development ; teacher learning ; n/a ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: English
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  • 16
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    International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 17
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    From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders；celiac disease；gluten intolerance ; bic Book Industry Communication::M Medicine
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  • 18
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    Placing Empire (2021)
    University of California Press
    Details
    Publication Date: 2024-04-01
    Description: Placing Empire examines the spatial politics of Japanese imperialism through a study of Japanese travel and tourism to Korea, Manchuria, and Taiwan between the late nineteenth century and the early 1950s. In a departure from standard histories of Japan, this book shows how debates over the place of colonized lands reshaped the social and spatial imaginary of the modern Japanese nation. In turn, this sociospatial imaginary affected the ways in which colonial difference was conceptualized and enacted. The book thus illuminates how ideas of place became central to the production of new forms of colonial hierarchy as empires around the globe transitioned from an era of territorial acquisition to one of territorial maintenance.
    Keywords: geography of civilization ; colonial difference ; taiwan ; japanese empire ; korea ; spatial history ; place ; tourism ; manchuria ; geography of cultural pluralism ; Indigenous peoples ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Microglia in Health and Disease: A Unique Immune Cell Population (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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    Civility in Uncivil Times (2022)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: Kazimierz Moczarski (1907–1975) was a journalist, soldier, and political prisoner. His life exemplifies a Central European biography under Nazism and Comunism. The addictive and moving Civility in Uncivil Times reveals the story of a man who defended law and democracy all his life. Moczarski fought for it in the authoritarian Poland of the 1930s. During the Second World War, he partook in the resistance movement. After the war, he spent eleven years in a Stalinist prison, including nine months in one cell with the Nazi Jürgen Stroop, who commanded the brutal pacification of the Warsaw Ghetto. The communists imprisoned Moczarski’s wife. After release, he rebuilt the broken marriage, rejoined social life, and wrote a work about meeting Stroop. Translated into many languages, Conversations with the Executioner is a thorough study of totalitarianism.
    Keywords: anti-Semitism ; Battle ; Biography ; Civility ; Kazimierz ; Machcewicz ; Moczarski ; Moczarski's ; Polish ; political prisoner ; post-Stalinist thaw ; Prison ; prison letters ; Quiet ; Stalinism ; Stalinist ; terror ; Times ; Truth ; Uncivil ; Underground ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    The Severan Buildings of Lepcis Magna (2023)
    Society for Libyan Studies | Society for Libyan Studies
    Details
    Publication Date: 2024-04-02
    Description: The buildings erected in his native city by the Roman emperor Septimius Severus are amongst the most impressive and best-preserved in the Roman world. Because of their unique state of preservation, they give an unparalleled insight into what an architect with an imperial commission could do, when he had the building-materials and technical expertise of the entire empire at his disposal.〈br/>〈br/>The buildings excavated by Italian teams between the two World Wars were examined in detail by Ward-Perkins between 1948 and 1953. The study was never completed in his lifetime, though the drawings and much of the text existed at least in draft form. The present publication puts these in the public domain, together with Ward-Perkins' authoritative insights into the process by which such a grand project was executed.
    Keywords: History ; Ancient ; Rome ; Social Science ; Archaeology ; Architecture ; History ; Ancient & Classical ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::A The Arts::AM Architecture::AMX History of architecture
    Language: English
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    St Peter's, Barton-upon-Humber, Lincolnshire (2021)
    Historic England | Historic England
    Details
    Publication Date: 2024-03-23
    Description: St Peter's, Barton-upon-Humber, is a redundant medieval church in the care of English Heritage. As a result of a major program of research carried out between 1978 and 2007, it is now the most intensively studied parish church in the UK. Excavations between 1978 and 1984 investigated most of the interior of the building, as well as a swathe of churchyard around its exterior. At the same time, a stone-by-stone record and detailed archaeological study of the fabric and furnishings of the church was undertaken, continuing down to 2007. The twin aims of the project were to understand the architectural history and setting of this complex, multi-period building (Volume 1, Parts 1 and 2) and to recover a substantial sample of the population for palaeopathological study (Volume 2). An extensive program of historical and topographical research also took place in order to set the archaeological evidence firmly in context.
    Keywords: Architecture ; History ; History ; Europe ; Medieval ; History ; Europe ; Great Britain ; thema EDItEUR::A The Arts::AM Architecture::AMX History of architecture ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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    COVID-19: Current Status and Future Prospects (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    The Emergence of Ukraine (2021)
    Canadian Institute of Ukrainian Studies Press
    Details
    Publication Date: 2024-04-01
    Description: This book is a collection of essays by prominent historians from Austria, Germany, Ukraine, Poland and Russia, who undertook a thorough and detailed study of one as yet inadequately researched aspect of the First World War--the occupation of Ukraine by the Central Powers in 1918. The book provides a new and fresh perspective on the historical context of Ukraine’s struggle for independence following the First World War.
    Description: Die Ukraine war zu Ende des Ersten Weltkrieges zwischen den Zwängen des zerfallenden Russischen Reiches, den Mittelmächten, die große Gebiete besetzten, und einer starken, aber zersplitterten Unabhängigkeitsbewegung, eingezwängt. Erstmals versucht mit dieser Studie ein internationales Historikerteam mit Materialien aus Archiven in Moskau, St. Petersburg, Kiew, Warschau, Wien, London, Paris, Bern, Prag, Washington und aus den deutschen Archiven ein faszinierendes Bild des Unabhängigkeitszwanges der Ukraine zu zeichnen. Dabei wurde auch ein bisher kaum bearbeitetes Thema aufgebrochen: Die vielfach rücksichtslose Besatzung des Landes durch deutsche und österreichischungarische Truppen 1918 und ihre Auswirkungen und Folgen.
    Keywords: First World War ; Ukraine ; Russian Civil War ; Interwar Years ; Erster Weltkrieg ; Ukraine ; Russischer Bürgerkrieg ; Zwischenkriegszeit ; Austria-Hungary ; Bolsheviks ; Kiev ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Displaced Memories (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: The book is a comparative case study of collective memory in two small communities situated on two Central-European borderlands. Despite different pre-war histories, Ukrainian Zhovkva (before 1939 Polish Żółkiew) and Polish Krzyż (before 1945 German Kreuz) were to share a common fate of many European localities, destroyed and rebuilt in a completely new shape. As a result of war, and post-war ethnic cleansing and displacement, they lost almost all of their pre-war inhabitants and were repopulated by new people. Based on more than 150 oral history interviews, the book describes the process of reconstruction of social microcosm, involving the reader in a journey through the lives of real people entangled in the dramatic historical events of the 20th century.
    Keywords: Collective Identity ; Deportation and resettlement ; Displaced ; Forgetting ; Galicji ; Holocaust and ethnic cleansing ; Kopernika ; Memories ; Mikołaja ; Naukowe ; Odzyskanych ; pamięć ; pamięci ; Poland ; Polish-Ukrainian conflict ; Politics of memory ; polskich ; Post ; Przesiedlenia ; przykładzie ; Remembering ; Second World War ; społecznej ; Studium ; Ukraine ; ukraińskiej ; Uniwersytetu ; Wydawnictwo ; Wylegala ; Ziem ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    1989 and the West (2023)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-02
    Description: Back in 1989, many anticipated that the end of the Cold War would usher in the ‘end of history’ characterized by the victory of democracy and capitalism. At the thirtieth anniversary of this momentous event, this book challenges this assumption. It studies the most recent era of contemporary European history in order to analyse the impact, consequences and legacy of the end of the Cold War for Western Europe. Bringing together leading scholars on the topic, the volume answers the question of how the end of the Cold War has affected Western Europe and reveals how it accelerated and reinforced processes that shaped the fragile (geo-)political and economic order of the continent today. In four thematic sections, the book analyses the changing position of Germany in Europe; studies the transformation of neoliberal capitalism; answers the question how Western Europe faced the geopolitical challenges after the Berlin Wall came down; and investigates the crisis of representative democracy. As such, the book provides a comprehensive and novel historical perspective on Europe since the late 1980s.
    Keywords: Central and Eastern Europe ; Cold War ; End of Communism ; End of History ; Fall of the Berlin Wall ; Free Markets ; Nationalism ; Populism ; Shock Therapy ; 1989 ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHQ History of other geographical groupings and regions ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history
    Language: English
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    Dogmatism (2024)
    Bloomsbury Academic | Bloomsbury Academic
    Details
    Publication Date: 2024-04-02
    Description: Why does the history of dogmatism deserve our attention? This open access book analyses uses of the term, following dogmatism from Victorian Britain to Cold War America, examining why it came to be regarded as a vice, and how understandings of its meaning have evolved. Whilst the field of scientific thought is committed to continuous innovation, ideas about dogmatism – with their roots in ancient philosophy – are pervasive in scientific thought today. Carrying connotations of both vice and ecclesiastical authority, the term’s prevalence during the ‘age of science’, and the rise of new thought categories such as totalitarianism and creationism, prompted scholars to repeat the old wisdom that science is incompatible with dogmatism. Tracing the concept across decades and different disciplines, Paul and Stoeger demonstrate how it has survived not only the passage of time, but changes in language and scientific methodologies. The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 licence on bloomsburycollections.com. Open access was funded by Dutch Research Council (NWO).
    Keywords: dogmatism ; history of science ; history of dogmatism ; historiography ; history of the humanities ; scientific methodology ; history of dogma ; 19th century history ; 20th century history ; 21st century history ; age of science ; scientific thought ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHA History: theory and methods
    Language: English
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    Pathogenesis and Targeted Therapy of Epilepsy (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Chapter Rereading Italian Travellers to Africa: Precursors, Identities and Interracial Relations in Narratives of Italian Colonialism (2022)
    Firenze University Press
    Details
    Publication Date: 2024-04-01
    Description: This essay considers a number of travellers’ writings about Africa which are reread to construct and deconstruct Italian colonial identity. It focuses on Cesare Cesari’s Viaggi africani di Pellegrino Matteucci (1932), which deems Matteucci a precursor of Fascist colonialism and contributor to Fascist “colonial science”. The essay then moves on to explore the more recent rereading by Angelo Del Boca and Igiaba Scego of respectively Indro Montanelli’s XX Battaglione Eritreo (1936) and Errico Emanuelli’s Settimana nera (1961). By bringing together and rereading these texts, the essay maps the transformations of Italianness from colonial to postcolonial times and reveals how colonial identity relied on a series of gender, racial and sexual tropes of exploration and conquest.
    Keywords: Africa ; colonial identity ; race ; sex ; gender ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Nutraceuticals and Human Health (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-01
    Description: In this Special Issue, we have published papers on the health-promoting effects of nutraceuticals from different sources, and their effects in different pathologies. Extracts from plants have been analyzed, for example, extracts from olive leaves, Mikania micrantha, the devil’s claw, raspberries and others, alongside marine phytoplankton, egg-yolk and marketed dietary supplements. The effects of these extracts and dietary supplements have been studied in diseases associated with obesity, and in diseases where inflammation pathways are involved. The effectiveness of resveratrol and curcumin to support the anticancer activity of cisplatin has also been reported, as well as the ability of devil’s claw root extract to stimulate the CB2 receptors in synoviocytes in osteoarthritis patients. The anti-oxidant effect of marine phytoplankton has been studied on muscle damage, both in humans and in an animal model, and the effects of the metabolite of antocianin were analyzed in a mouse model of amyotrophic lateral sclerosis. Finally, reviews on the use of lactoferrin, ω3 and ω6 and abscisic acid have been reported, in addition to the crosstalk between prostate cancer and microbiota inflammation. Although it is not yet possible to draw definitive conclusions on the use of nutraceuticals, several mechanisms of action for many of them have been further clarified.
    Keywords: fertility ; ingredients ; male reproduction ; semen parameters ; supplements ; allithiamine ; garlic ; hyperglycaemia ; advanced glycation end-products ; cytokines ; abscisic acid ; prediabetes ; type 2 diabetes mellitus ; metabolic syndrome ; insulin resistance ; adipocyte browning ; AMP-activated protein kinase ; food supplement ; frambinone ; meal frequency ; open-field test ; elevated plus maze ; sensory motor gating ; pre-pulse inhibition ; c-Fos ; amyotrophic lateral sclerosis ; anti-inflammatory ; antioxidant ; phenolic acid ; neuroprotective ; neurodegeneration ; obesity ; overweight ; beta-glucans ; chitosan ; follow up study ; weight loss programs ; weight gain ; weight loss ; body weight changes ; phytoplankton ; antioxidants ; muscle damage ; muscle recovery ; muscle soreness ; Viburnum opulus ; phenolic compounds ; adipogenesis ; PPARγ ; lipase inhibition ; green tea ; epigallocatechin ; lipid profile ; high-fat diet ; fast food ; osteoarthritis ; nutraceuticals ; polyphenols ; volatile compounds ; β-caryophyllene ; eugenol ; FAAH ; cannabinoid receptors ; phospholipases ; lactoferrin ; bovine milk ; nutraceutical ; human health ; resveratrol ; curcumin ; cisplatin ; head and neck cancer ; cell cycle ; apoptosis ; prostate cancer ; microbiota ; nutraceutical compounds ; fecundation ; inflammation ; cytokine ; growth factors ; metabolomics ; lipidomics ; ω-3PUFAs ; ω-6PUFAs ; endocannabinoids ; CRC ; fatty acids ; Gymnema inodorum ; gymnemic acid ; Mikania micrantha ; anti-hypercholesterolemia ; steatosis ; olive leaf ; macrophages ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
    Language: English
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
    Language: English
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    Implementation and Scale Up of Point of Care (POC) Diagnostics in Resource-Limited Settings (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-01
    Description: Scale up and implementation of new point-of-care (POC) diagnostics is a global health priority to enable the adoption of new evidence-based POC diagnostics and to replicate and extend the reach of POC diagnostics. Global private and public sector agencies have significantly increased their investment in the development of POC diagnostics to meet the unmet needs of patients in resource-limited settings, particularly disease burdened settings with limited access to laboratory infrastructure. However, previous research has demonstrated that the availability of health technologies in these settings does not always guarantee patient-centered outcomes. The applicability, effectiveness and sustainability of diagnostic technologies is affected by the involvement of all stakeholders during planning and implementation, which must be relevant to each specific context and sensitive to local culture. Factors such as infrastructure, resources, values and characteristics of participants can influence the implementation, scalability and sustainability of health interventions such as POC diagnostics. This book, “Implementation and Scale up of Point of Care (POC) Diagnostics in Resource-Limited Settings”, presents literature reviews and primary research studies focusing on the implementation and scale up of POC diagnostics in resource-limited settings.
    Keywords: point-of-care-ultrasound ; ultrasound ; implementation ; point of care ultrasound ; augmented reality ; telemedicine ; spatial accessibility ; blood group ; rhesus type ; point-of-care testing ; maternal healthcare ; Upper East Region ; Ghana ; point-of-care ultrasound ; medical education ; syphilis ; maternal mortality ; interrupted time series ; segmented regression analysis ; point-of-care CD4+ t testing ; qualitative survey ; acceptability ; patients ; healthcare providers ; primary healthcare clinics ; HIV self-testing ; scale-up ; key stakeholder ; quality HIV point-of-care-diagnostics ; nominal group technique ; stakeholder engagement ; self-testing ; novel coronavirus disease-19 ; blockchain ; artificial intelligence ; geographical access ; glucose-6-phosphate dioxygenase deficiency ; antenatal care ; upper east region ; schistosomiasis ; barriers to diagnostics ; access to healthcare ; end-user perspectives ; neglected tropical diseases ; Nigeria ; case management ; electronic health information system ; diagnosis ; treatment ; point-of-care ; low and middle income countries ; point-of-care diagnostics ; healthcare services ; COVID-19 era ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
    Language: English
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    Junian Latinity in the Roman Empire Volume 1 (2023)
    Edinburgh University Press
    Details
    Publication Date: 2024-04-02
    Description: This book offers new historical, legal and literary explorations of a status held by uncountable formerly enslaved persons in the Roman Empire: Junian Latinity. It is the first book in any language to provide comprehensive multi-disciplinary study of this status. Divided in two parts, the book sets the scene with six chapters that discuss the legal innovations that created Junian Latinity, as well as the historical contexts in which the status was conceived and in which it developed – from the late republican period to the early medieval world. Four chapters in the second book part offer then new research on key Latin literary texts to provide fresh insights into the role of Junian Latinity in Roman imperial society. The book makes a strong case for the centrality of Junian Latinity in the Roman Empire and the importance of its modern study.
    Keywords: History ; Classical Studies ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Droits et voix / Rights and Voices : La Criminologie (2021)
    Les Presses de l’Université d’Ottawa | University of Ottawa Press
    Details
    Publication Date: 2024-04-01
    Description: This volume commemorates the 40th anniversary of the University of Ottawa’s Department of Criminology, founded in 1968. It relates the history of the department from its origins to today, focusing on the theoretical debates that have influenced its critical and self reflexive approach to criminology. The contributions to this volume continue in that vein by questioning the traditional perspective of criminology on a variety of topics including police studies, mental health, political violence, suicide, and crime prevention. Rights and Voices reveals the significant role that the University of Ottawa has played in redefining criminology to advocate activism, social justice, and compassion.
    Keywords: H1-99 ; law ; criminology ; social justice ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Augustine and the Art of Ruling in the Carolingian Imperial Period (Open Access) (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-01
    Description: This volume is an investigation of how Augustine was received in the Carolingian period, and the elements of his thought which had an impact on Carolingian ideas of ‘state’, rulership and ethics. It focuses on Alcuin of York and Hincmar of Rheims, authors and political advisers to Charlemagne and to Charles the Bald, respectively. It examines how they used Augustinian political thought and ethics, as manifested in the De civitate Dei, to give more weight to their advice. A comparative approach sheds light on the differences between Charlemagne’s reign and that of his grandson. It scrutinizes Alcuin’s and Hincmar’s discussions of empire, rulership and the moral conduct of political agents during which both drew on the De civitate Dei, although each came away with a different understanding. By means of a philological–historical approach, the book offers a deeper reading and treats the Latin texts as political discourses defined by content and language.
    Keywords: Augustine ; De Civitate Dei ; Rulership ; Alcuin ; Hincmar ; Early medieval Europe ; Carolingian ; Ethics ; Political thought ; Charlemagne ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Acute and Chronic Changes in Neural Excitability During Physical Activity in Non-Pathological States (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-01
    Description: Neural control of human motor output and how it is modified by alterations in physical activity levels is complex and multidimensional. The use of various experimental designs has vastly increased our knowledge of how the nervous system integrates descending, segmental, and ascending information to produce motor outputs, yet there is still much to learn. A more complete picture of the neurophysiology underlying the control of human motor outputs may prove useful in guiding rehabilitation programs aimed at reducing motor impairments following disease or injury. The purpose of this Special Issue is to collect original articles that explore neural excitability in various states. Studies examining neural excitability on a moment-to-moment basis (acute) or following prolonged periods of exercise or skill training and disuse (chronic) are encouraged. Original research studies using various experimental measures (e.g., transcranial magnetic stimulation, transmastoid electrical stimulation, single motor unit recordings, electroencephalography, and measures of spinal reflexes) in various states (e.g., fatigued, non-fatigued, and resting) during different types of motor outputs (tonic or dynamic) are encouraged. Experimental studies and literature reviews are welcome.
    Keywords: thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Language: English
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    Tajkistan: A Political and Social History (2021)
    ANU Press
    Details
    Publication Date: 2024-03-23
    Description: This book is a historical study of the Tajiks in Central Asia from the ancient times to the post-Soviet period. For millennia, these descendants of the original Aryan settlers were part of many different empires set up by Greek, Arab, Turkic and Russian invaders, as well as their own, most notably during the Middle Ages. The emergence of the modern state of Tajikistan began after 1917 under Soviet rule, and culminated in the promulgation of independence from the moribund USSR in 1991. In the subsequent civil war that raged between 1992 and 1997, Tajikistan came close to becoming a failed state. The legacy of that internal conflict remains critical to understanding politics in Tajikistan a generation later. Exploring the patterns of ethnic identity and the exigencies of state formation, the book argues that despite a strong sense of belonging underpinned by shared history, mythology and cultural traits, the Tajiks have not succeeded in forming a consolidated nation. The politics of the Russian colonial administration, the national-territorial delimitation under Stalin, and the Soviet strategy of socio-economic modernisation contributed to the preservation and reification of sub-ethnic cleavages and regional identities. The book demonstrates the impact of region-based elite clans on Tajikistan’s political trajectory in the twilight years of the Soviet era, and identifies objective and subjective factors that led to the civil war. It concludes with a survey of the process of national reconciliation after 1997, and the formal and informal political actors, including Islamist groups, who compete for influence in Tajik society. “Tajikistan: A Political and Social History is the best source of information on this important country in the English language. Drs Nourzhanov and Bleuer present a comprehensive yet detailed account of the past and prospects of this emerging nation, and have filled one of the major gaps in Central Asian scholarship. This book must be read by those who wish to grasp the vagaries of Central Asia’s evolving political and cultural landscapes.” Reuel Hanks, Professor of Geography, Oklahoma State University, and Editor of the Journal of Central Asian Studies. “If Tajikistan is known outside its region, it is often for the civil war that gravely damaged it. This volume authoritatively provides the longer perspective to the unsettling events of the 1990s and skilfully explains them in terms of history, social structure, and sub-state identities. In addition to highlighting a wealth of local factors, it is insightful on the ways in which antagonists can be transformed into broader ethnic and regional blocs. Kirill Nourzhanov and Christian Bleuer are erudite guides to an understudied part of Central Asia, while astutely instructing us about larger patterns of state-society relations and their impact on the logic of conflict.” James Piscatori, Professor of International Relations, Durham University.
    Keywords: history ; tajikistan ; Central Asia ; Dushanbe ; Soviet Union ; Tajiks ; thema EDItEUR::1 Place qualifiers::1F Asia::1FC Central Asia::1FCD Tajikistan (Tadzhikistan) ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Everyday Political Objects (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-02
    Description: Ages, Christopher, Contemporary, Everyday, Fletcher, Middle, Objects, Political, World
    Keywords: Ages, Christopher, Contemporary, Everyday, Fletcher, Middle, Objects, Political, World ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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    Corporate Policing, Yellow Unionism, and Strikebreaking, 1890-1930 (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-02
    Description: This book provides a comparative and transnational examination of the complex and multifaceted experiences of anti-labour mobilisation, from the bitter social conflicts of the pre-war period, through the epochal tremors of war and revolution, and the violent spasms of the 1920s and 1930s. It retraces the formation of an extensive market for corporate policing, privately contracted security and yellow unionism, as well as processes of professionalisation in strikebreaking activities, labour espionage and surveillance. It reconstructs the diverse spectrum of right-wing patriotic leagues and vigilante corps which, in support or in competition with law enforcement agencies, sought to counter the dual dangers of industrial militancy and revolutionary situations. Although considerable research has been done on the rise of socialist parties and trade unions the repressive policies of their opponents have been generally left unexamined. This book fills this gap by reconstructing the methods and strategies used by state authorities and employers to counter outbreaks of labour militancy on a global scale. It adopts a long-term chronology that sheds light on the shocks and strains that marked industrial societies during their turbulent transition into mass politics from the bitter social conflicts of the pre-war period, through the epochal tremors of war and revolution, and the violent spasms of the 1920s and 1930s. Offering a new angle of vision to examine the violent transition to mass politics in industrial societies, this is of great interest to scholars of policing, unionism and striking in the modern era.
    Keywords: Armed Associations ; Austria-Hungary ; Czarism ; Dublin Lockout ; Geoff Eley ; Iberian Peninsula ; Industrial vigilantism ; Proto-Fascism ; Russian Empire ; The Dark Side of the Belle Époque ; Tsarism ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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    Our Unswerving Loyalty (2021)
    ANU Press
    Details
    Publication Date: 2024-04-02
    Description: The story of the Communist Party of Australia has been told in various ways. Until now, however, archival collections that have borne on this story have been relatively inaccessible to the ordinary, interested reader. This book begins to redress that deficiency by bringing together 85 key documents from the Russian State Archives of Social and Political History (RGASPI), selected from a collection of thousands of documents concerning the relations between the Communist International and the Communist Party of Australia. The selection focuses on the relationship between the CPA and the Comintern because the activities of the CPA are essentially incomprehensible without understanding the international communist context within which the CPA operated. That context was dominated by the newly-created Soviet state and its decision to authorize and utilize a network of communist parties throughout the world. The documents in this work suggest three major propositions about the relationship between the CPA and the Comintern. First, that the Comintern was crucial in the formation of the CPA, via its emissaries, instructions and authority. Second, that the Comintern played a major role in directing the policies of the CPA in domestic matters (not to mention in international matters, where the Comintern’s decisions were supreme). And third, that the leadership of the CPA was, from 1929 onwards, shaped, trained and authorized by the Comintern. With access to the documents, readers now have a chance not just to hear the voices of the times, but to make their own judgements about the relationship between the CPA and Moscow. The book also includes two extended introductory essays that outline the development of the Comintern and its relations with the CPA, as well as supporting materials that provide information on individuals, organizations and tactics mentioned within the documents themselves.
    Keywords: politics and government ; relations ; australia ; history ; soviet union ; communism ; Capitalism ; Moscow ; Trade union ; Working class ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    A Journey to Inner Africa (2022)
    Amherst College Press | Amherst College Press
    Details
    Publication Date: 2024-04-02
    Description: In 1847, Russian military engineer and diplomat Egor Petrovich Kovalevsky embarked on a journey through what is today Egypt, Sudan, Eritrea, and Ethiopia, recording his impressions of a region in flux. Invited by Egyptian ruler Mohammed Ali to look for gold and construct mines in the area between the Blue and White Nile, Kovalevsky captured the social milieu of both elites and ordinary people as well as compiled a rich record of the Upper Nile’s climate and natural resources. A Journey to Inner Africa, masterfully translated into English for the first time by Anna Aslanyan, is both a tale of encounter between Russia and northern Africa and an important document in the history and development of the Russian imperial project.
    Keywords: Kovalevskīĭ, E. P. (Egor Petrovich), -- 1811-1868 -- Travel -- Africa. ; Kovalevskīĭ, E. P. (Egor Petrovich), -- 1811-1868 -- Travel -- Egypt. ; Russians -- Africa -- History -- 19th century. ; Mining engineering -- Egypt -- History -- 19th century. ; Africa -- History -- To 1884. ; Egypt -- History -- 1798- ; Russia -- Foreign relations -- Africa. ; Africa -- Foreign relations -- Russia. ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHQ History of other geographical groupings and regions
    Language: English
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    Beyond Exceptionalism (2021)
    De Gruyter | De Gruyter Oldenbourg
    Details
    Publication Date: 2024-04-02
    Description: While the economic involvement of early modern Germany in slavery and the slave trade is increasingly receiving attention, the direct participation of Germans in human trafficking remains a blind spot in historiography. This edited volume focuses on practices of enslavement taking place within German territories in the early modern period as well as on the people of African, Asian, and Native American descent caught up in them.
    Keywords: Slavery ; Germany ; Atlantic history ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTR National liberation and independence ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTS Slavery and abolition of slavery
    Language: English
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    Chapter Il rilievo di strada tra conoscenza e valorizzazione urbana: via dei Papareschi a Roma (2022)
    FrancoAngeli
    Details
    Publication Date: 2024-04-03
    Description: The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences.
    Keywords: Discipline of representation, History, Semiotics, Science, Technology ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: Italian , English
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    Disasters and History (2021)
    Cambridge University Press
    Details
    Publication Date: 2024-04-01
    Description: This monograph provides an overview of research into disasters from a historical perspective, making two new contributions. First, it introduces the field of ‘disaster studies’ to history, showing how we can use history to better understand how societies deal with shocks and hazards and their potentially disastrous outcomes. Second, we introduce historians to the topic of disasters and the field of disaster studies, and explicitly show the relevance of studying past disasters to better understand the social, economic, and political functioning of past societies.
    Keywords: history ; disaster studies ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Chapter Frank Lloyd Wright: Models in Exhibitions (1932-1949) (2022)
    FrancoAngeli
    Details
    Publication Date: 2024-04-06
    Description: The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences.
    Keywords: Discipline of representation, History, Semiotics, Science, Technology ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: Italian , English
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    Local Self-Governance in Antiquity and in the Global South (2023)
    De Gruyter | De Gruyter
    Details
    Publication Date: 2024-04-03
    Description: Society begins at the local level. This interdisciplinary volume analyzes different kinds of local self-organization against the backdrop of the rather limited states of Antiquity and the Global South of the present. By collaborating across different periods of time the contributors get a better grasp of the mechanisms by which local governance succeeds, and advance the theoretical debate on state and society.
    Keywords: civil society ; collective identity ; global history ; limited statehood ; thema EDItEUR::D Biography, Literature and Literary studies::DB Ancient, classical and medieval texts ; thema EDItEUR::N History and Archaeology::NH History::NHA History: theory and methods ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology::NK Archaeology::NKD Archaeology by period / region ; thema EDItEUR::1 Place qualifiers::1Q Other geographical groupings: Oceans and seas, historical, political etc::1QB Historical states, empires, territories and regions::1QBA Ancient World ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPR Regional, state and other local government
    Language: English
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    Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
    Language: English
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    Prognostic Factors for Pediatric Tumors (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Rethinking Interdisciplinarity across the Social Sciences and Neurosciences (2021)
    Springer Nature | Palgrave Macmillan
    Details
    Publication Date: 2024-04-01
    Description: This book offers a provocative account of interdisciplinary research across the neurosciences, social sciences and humanities. Setting itself against standard accounts of interdisciplinary 'integration,' and rooting itself in the authors' own experiences, the book establishes a radical agenda for collaboration across these disciplines. Rethinking Interdisciplinarity does not merely advocate interdisciplinary research, but attends to the hitherto tacit pragmatics, affects, power dynamics, and spatial logics in which that research is enfolded. Understanding the complex relationships between brains, minds, and environments requires a delicate, playful and genuinely experimental interdisciplinarity, and this book shows us how it can be done.
    Keywords: neurosciences ; interdisciplinarity ; social sciences ; interdisciplinary research ; integration ; humanities ; Des Fitzgerald ; Epistemology ; Sociology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    The Mauritian Novel (2023)
    Liverpool University Press
    Details
    Publication Date: 2024-03-26
    Description: An Open Access edition of this work is available on Modern Languages Open (https://www.modernlanguagesopen.org/). On 12 March 2018, Mauritius celebrated fifty years as an independent nation amidst much fanfare. Yet behind the nation's official image of multicultural 'unity in diversity' lurk deep socio-economic inequalities and inter-ethnic tensions that are insistently critiqued in its literature. Against this backdrop, this book analyses how the idea of belonging - a sense of attachment to, and identification with, a place or people - is problematised in a range of contemporary francophone Mauritian novels. The island-nation's complex history and the multi-ethnic composition of its modern-day population mean that belonging is a central but fraught issue in both reality and fiction. Waters explores how diverse forms of affirmative, affective belonging intersect with, and are frequently inhibited by, exclusionary 'politics of belonging' at communal, national or international levels. Using an eclectic theoretical approach to the central concept of belonging, Waters offers in-depth textual analyses of novels by leading Mauritian writers Nathacha Appanah, Ananda Devi, Shenaz Patel, Bertrand de Robillard, Amal Sewtohul and Carl de Souza. Despite their thematic and formal diversity, these novels are shown to be characterised by a common rejection of dominant discourses of ethnic, diasporic affiliation and by a common commitment to the ongoing, future-orientated project of Mauritian nationhood. As such, this book offers an original insight into the dynamics of belonging and exclusion in diverse, multi-ethnic societies.
    Keywords: Language & Literature ; European Studies ; African Studies ; History ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Polymer Materials in Biomedical Application (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    Textiles in Ancient Mediterranean Iconography (2021)
    Oxbow Books | Oxbow Books
    Details
    Publication Date: 2024-04-02
    Description: This volume provides an ambitious synopsis of the complex, colourful world of textiles in ancient Mediterranean iconography. A wealth of information on ancient textiles is available from depictions such as sculpture, vase painting, figurines, reliefs and mosaics. Commonly represented in clothing, textiles are also present in furnishings and through the processes of textile production. The challenge for anyone analysing ancient iconography is determining how we interpret what we see. As preserved textiles rarely survive in comparable forms, we must consider the extent to which representations of textiles reflect reality, and critically evaluate the sources. Images are not simple replicas or photographs of reality. Instead, iconography draws on select elements from the surrounding world that were recognisable to the ancient audience, and reveal the perceptions, ideologies, and ideas of the society in which they were produced. Through examining the durable evidence, this anthology reveals the ephemeral world of textiles and their integral role in the daily life, cult and economy of the ancient Mediterranean.
    Keywords: History ; Ancient ; Rome ; History ; Ancient ; Design ; Textile & Costume ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::A The Arts::AK Design, Industrial and commercial arts, illustration::AKT Fashion and textile design
    Language: English
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    How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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    Chapter La normalizzazione iconografica della pittura vascolare per l’insegnamento. Il cratere attico del Pittore di Providence (2022)
    FrancoAngeli
    Details
    Publication Date: 2024-04-03
    Description: The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences.
    Keywords: Discipline of representation, History, Semiotics, Science, Technology ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: Italian , English
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    The Word Illuminated (2023)
    Details
    Publication Date: 2024-04-01
    Description: Diplomatic gifts, war prizes, or library treasures of royal and princely libraries—handwritten Qurʾans have also been endowed to mosques, tombs, and other religious complexes to perpetuate and transmit their baraka (divine blessing). Artistic, historic, and religious contexts and materiality of Qurʾans are investigated, from use of costly materials such as gold and parchment to development of special scripts, intricate illuminated designs, and meticulously tooled bindings. This edited collection resulted from a 2016 symposium at the Smithsonian’s Arthur M. Sacker Gallery in conjunction with the exhibition The Art of the Qurʾan: Treasures from the Museum of Turkish and Islamic Arts.
    Keywords: Quran'ic studies ; manuscript studies ; Islamic studies ; Islamic art ; Arabic ; calligraphy ; art history ; illumination ; book arts ; codicology ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Chapter The Luwian Goddess Darawa (2023)
    Firenze University Press
    Details
    Publication Date: 2024-04-01
    Description: The PN Kammalia-Tarawa in an Old Assyrian tablet seems to be the earliest reference of the deity Darawa. The Luwian background this deity is also apparent, e.g., from the plural form DDa-ra-ú-wa-an-zi or from those texts mentioned in CTH 457 and the etymological interpretation of the divine name to the Luwian verb tarāwi(ya)-. Since the early Middle Hittite period Darawa also found her way into the Hattian milieu and as a goddess connected with the family life, she is mentioned several times in festivals for a queen (CTH 646), but also in the Hittite Prayer to the Sun-goddess of the Netherworld (CTH 371) which is – in my opinion – the only Hittite texts mentioning Darawa within the “pantheon of the state”. Texts from the Hurrian and Kizzuwatnaean milieu (e.g., CTH 351) also refer several times to Darawa, but this is clearly the result of a secondary and marginal dissemination of the goddess. In conclusion one might say that Darawa from her Luwian background also came into contact with various milieus of the “Hittite pantheon”, functioning as a goddess providing good (and evil) to humans in everyday life.
    Keywords: Darawa ; Kuduili ; Festival of a Queen ; non-state religion ; Luwian-Hittite contacts ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Athanasius Raczyński (1788–1874). Aristocrat, Diplomat, and Patron of the Arts (2024)
    Brill
    Details
    Publication Date: 2024-03-23
    Description: This book depicts the long rich life and wide ranging work of Count Athanasius Raczyński (1788–1874). By exploring his complex personality, his processes of thought and his accomplishments, it reveals a man at once a wealthy aristocrat, a Pole in the Prussian diplomatic service, an active participant in and perceptive observer and critical commentator on political life, a connoisseur and art collector of European renown, and the author of ground breaking studies on German and Portuguese art – in short a distinguished and fascinating nineteenth century figure.
    Keywords: 19th-century Berlin ; aristocracy ; art collecting ; art historiography ; German painting ; History of collections ; history of diplomacy ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGA History of art ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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    Chapter Alberi monumentali e giardini storici: un processo virtuoso di disseminazione e fruizione (2022)
    FrancoAngeli
    Details
    Publication Date: 2024-04-06
    Description: The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences.
    Keywords: Discipline of representation, History, Semiotics, Science, Technology ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: Italian , English
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    Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Recent advances in γδ T cell biology: New ligands, new functions, and new translational perspectives (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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    ME/CFS – the Severely and Very Severely Affected (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-01
    Description: Manuscripts in this monograph are sorted into five categories: 1. Case Reports: a description of living as a bedridden patient; structured interviews with severely affected ME/CFS patients; how past events contribute to severe ME/CFS; a comparison of moderately ill, severely ill, and very severely ill; case reports of ME/CFS in children. 2. A healthcare provider’s view of managing ME/CFS patients. 3. Characterization of the Severely and Very Severely Affected: (1) the most troubling symptoms; (2) disease severity diminishes capacity for exercise, (3) operationalized definitions of the severely ill and very severely ill; (4) the usefulness of a modified Korean Chalder Fatigue Scale Questionnaire; (5) cardiac dimensions and function in patients; (6) an easier tilt test; and (7) review of sleep studies. 4. Progress in Diagnosis and Treatment: (1) objective measures for grading ME/CFS; (2) a sitting tilt test for orthostatic intolerance; (3) the benefits of IVIgG; (4) risks and protective factors in suicidality; (5) malnutrition and overcoming it; (7) partnerships between patients, caregivers, and providers, and the use of technology; (8) a holistic model of care, “Compassion in Practice; and (9) the effects of suffering, utilizing a four-phase model. 5. Impact of the Disease: (1) a historical perspective; (2) the impact of ME/CFS on psychosocial dynamics; (3) the educational needs of school-aged; and (4) the economic impact of ME/CFS
    Keywords: Adolescence ; Adulthood ; Apnea ; Apnea-hypopnea index ; Bedbound ; Cardiac Function ; Cardiopulmonary Exercise Testing ; Caregivers ; Case Study ; Cerebral Blood Flow ; Chronic Fatigue Syndrome ; Clinical Presentation ; Compassion In Practice ; Diagnosis ; Economic Impact ; Education ; Enteral Nutrition ; EUROMENE ; Europe-Wide ; Grief ; Homebound ; Illness progression ; Immunoglobulin Therapy ; Infection ; Isolation ; IVIgG ; Jarisch&ndash ; Herxheimer Reaction ; Laboratory Tests ; Lived experience ; Loss ; Malnutrition ; Mental Health ; ME/CFS ; Moderately Ill ; Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ; Orthostatic Stress ; Parenteral nutrition ; Patient Assessment ; Patient Management ; Prevention ; Psychological Causation ; Psychosocial ; Severely Ill ; Sleep ; Social Isolation ; Stigma ; Student Learning ; Suicidality ; Symptoms ; Telemedicine ; Trauma ; Treatment ; Tube feeding ; Very Severely III ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
    Language: English
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    Traditional Medicines and Globalisation (2021)
    Maven Publishers
    Details
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
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    Medieval Jewry in Northern France (2022)
    Johns Hopkins University Press
    Details
    Publication Date: 2024-04-02
    Description: Originally published in 1974. Focusing on a set of Jewish communities, Robert Chazan tells how, by the eleventh century, French Jews had created for themselves a role as local merchants and moneylenders in adapting to the political, economic, and social limits imposed on them. French society, striving to become more powerful and civilized, was willing to extend aid and protection to the Jews in return for general stimulation of trade and urban life and for the immediate profit realized from taxation. While the authorities were relatively successful in protecting the Jews from others, there was no power to impose itself between the Jews and their protectors. The political and social well-being of the Jews was, therefore, dependent on the will of the governing authorities who taxed their holdings and regulated their activities. During the twelfth and thirteenth centuries, the position of the Jews was constantly under attack by reform elements in the church concerned with Jewish moneylending and blasphemous materials in Jewish books; these reformers were eventually devoted to a serious missionizing effort within the Jewish community. The Jews' situation was further complicated by deep popular animosity, expressing itself in a damaging set of slanders and occasionally in physical violence. Despite the impressive achievements of the Jews in medieval northern France, by the thirteenth century their community was increasingly constricted; and in 1306, they were expelled from royal France by Philip IV. Overcoming the handicap of a lack of copious source material, Chazan analyzes the Jews' political status, their relations with key elements of Christian society, their demographic development, their economic outlets, their internal organization, and their attitudes toward the Christian environment. As it highlights aspects of French society from an unusual perspective, Medieval Jewry in Northern France should be of special interest to the historian of medieval France as well as to the student of Jewish history. This story is also significant for all who are fascinated by the capacity of human groups to respond and adapt creatively to a hostile and limiting environment.
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Outdoor Adventure Education (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-02
    Description: The overall focus, scope, and purpose of this Special Issue on outdoor adventure is to provide the current and anticipated future trends, offer innovative ideas for new programs, support decision making for managers to move plans and intentions into action, inspire pioneering staff training and leadership development, incite policy reviews and revisions, promote resource (re)allocation where needed, and stimulate culture shifts among outdoor leaders and managers. Furthermore, this Special Issue is situated within the existing literature by depicting major trends in the field, exploring organizational issues and successes, identifying gaps between research and practice, and formulating solutions to some of the field’s most pressing challenges. Of particular interest were manuscripts reporting the following: • Adventure education across diverse cultures; • Innovative partnerships for experiential education outdoors; • Land management agencies working with adventure education programs; • Leadership and/or management issues and challenges; • Programming advances, participation trends; • Recruitment and retention of diverse staff, workforce enhancement; • Social groups/identity and outdoor spaces (e.g., people of color and outdoor adventure; women in the outdoors—where have we been, where are we going?; LGBTQ trends and future directions; youth and outdoor adventure); • Socioeconomic factors and solutions; • Technology influences and adventure education; • Working with schools/school districts and being in sync with curriculum needs, supporting transportation challenges, etc.
    Keywords: outdoor adventure education ; social justice ; inclusive praxis ; Outward Bound ; policy ; purposes ; practice ; barriers ; outdoor learning ; outdoor and adventure education ; international perspectives ; comparative ; experiential learning ; transformative learning ; equity ; pedagogy ; whiteness ; gender ; critical theory ; outdoor education ; outdoor skills ; partnership ; outdoor programs ; outdoor education in urban areas ; outdoor recreation ; female empowerment ; single-gender ; adolescent programming ; adolescent girls ; outdoor camp ; girls’ camp ; youth development ; treasure hunt ; mobile learning ; geocaching ; smartphone ; educational app ; Lesvos island ; secondary education students ; undergraduate students ; nature-based programs ; ecological framework ; COVID-19 impact ; n/a ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: English
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    Making Muslim Women European (2021)
    Central European University Press
    Details
    Publication Date: 2024-04-04
    Description: This social, cultural, and political history of Slavic Muslim women of the Yugoslav region in the first decades of the post-Ottoman era is the first to provide a comprehensive overview of the issues confronting these women. It is based on a study of voluntary associations (philanthropic, cultural, Islamic-traditionalist, and feminist) of the period. It is broadly held that Muslim women were silent and relegated to a purely private space until 1945, when the communist state “unveiled” and “liberated” them from the top down.  After systematic archival research in Bosnia, Croatia, Serbia, and Austria, Fabio Giomi challenges this view by showing:  How different sectors of the Yugoslav elite through association publications, imagined the role of Muslim women in post-Ottoman times, and how Muslim women took part in the construction or the contestation of these narratives.  How associa­tions employed different means in order to forge a generation of “New Muslim Women” able to cope with the post-Ottoman political and social circumstances.  And how Muslim women used the tools provided by the associations in order to pursue their own projects, aims and agendas.  The insights are relevant for today’s challenges facing Muslim women in Europe. The text is illustrated with exceptional photographs.
    Keywords: History ; Women ; History ; Europe ; Eastern ; Social Science ; Gender Studies ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups
    Language: English
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    Ginseng and Borderland (2021)
    University of California Press | University of California Press
    Details
    Publication Date: 2024-04-01
    Description: Ginseng and Borderland explores the territorial boundaries and political relations between Qing China and Chosŏn Korea during the period from the early seventeenth to the late nineteenth centuries. By examining a unique body of materials written in Chinese, Manchu, and Korean, and building on recent studies in New Qing History, Seonmin Kim adds new perspectives to current understandings of the remarkable transformation of the Manchu Qing dynasty (1636–1912) from a tribal state to a universal empire. This book discusses early Manchu history and explores the Qing Empire’s policy of controlling Manchuria and Chosŏn Korea. Kim also contributes to the Korean history of the Chosŏn dynasty (1392–1910) by challenging conventional accounts that embrace a China-centered interpretation of the tributary relationship between the two polities, stressing instead the agency of Chosŏn Korea in the formation of the Qing Empire. This study demonstrates how Koreans interpreted and employed this relationship in order to preserve the boundary—and peace—with the suzerain power. By focusing on the historical significance of the China-Korea boundary, this book defines the nature of the Qing Empire through the dynamics of contacts and conflicts under both the cultural and material frameworks of its tributary relationship with Chosŏn Korea.
    Keywords: History ; General ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Research Topics in Medicines and How Our Board Members Are Engaged in Them (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Arendt, Eichmann and the Politics of the Past (2022)
    Helsinki University Press | Helsinki University Press
    Details
    Publication Date: 2024-04-02
    Description: Arendt, Eichmann and the Politics of the Past offers a critical analysis of the original American debate over Hannah Arendt’s report of the trial of Adolf Eichmann. First published in 2008, Tuija Parvikko’s book discusses both the campaign against Arendt organised by American Zionist organisations and the controversy Arendt’s report caused within American Jewish intellectual circles. Parvikko’s analysis carefully draws from the historical background of the report, discussing Arendt’s early studies of Zionism and her critique of the Jewish state. The volume also gives an account of Eichmann’s capture in Argentina and the reception of the report among legal scholars and the world press.;This edition includes a new prologue in which Parvikko reflects on her own account in connection to recent academic discussions on the controversy. The author’s analysis also covers contributions that have attempted to follow Arendt’s notion of thinking without banisters. With them, Parvikko engages in debate about going beyond Arendt’s theoretical reflections on cohabitation, sharing the world, and discussing the new political evils of the present world without pregiven norms and patterns of thought.
    Keywords: political judgement ; the politics of the past ; the Eichmann trial ; victimology ; political trial ; Hannah Arendt ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::Y Children’s, Teenage and Educational::YF Children’s / Teenage fiction and true stories::YFT Children’s / Teenage fiction: Historical fiction ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: English
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    Chapter Il disegno delle gemme sfaccettate. Fonti iconografiche e trattatistica, analisi geometrica, rilevamento, modellazione parametrica (2022)
    FrancoAngeli
    Details
    Publication Date: 2024-04-03
    Description: The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences.
    Keywords: Discipline of representation, History, Semiotics, Science, Technology ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: Italian , English
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    History and Drama (2021)
    De Gruyter
    Details
    Publication Date: 2024-03-24
    Description: Historiography and literature are verbal representations of actions and events that either have happened or could happen in the human lifeworld. As such, they possess an uncanny ‘family resemblance’ that has impelled theorists since Antiquity to define the limits of the two ‘sister arts.’ Historiographical texts, from one point of view, are liable to veer towards fiction.
    Keywords: history ; literature ; thema EDItEUR::D Biography, Literature and Literary studies ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    The City by the Pool (2021)
    Historic England | Historic England
    Details
    Publication Date: 2024-04-04
    Description: This volume offers a new and up-to-date synthesis of Lincoln's long history as a major city and regional capital, from prehistory to 1945. The 'City by the Pool' was a major religious centre long before the Roman invasion and from bronze-age shamans to early Baptists people have always been attracted here for spiritual as well as mundane purposes. The authors argue for the presence of a major ritual causeway of the late Bronze and Iron Age and outline the extent to which ritual monuments also contributed to the character of Roman Lincoln. This book is based on more than a hundred publicly-funded excavations and building surveys undertaken between 1945 and 2000. It surveys all aspects of city life, from housing and fortifications to the water supply and rubbish disposal. It includes a CD Rom with a Geographic Information System (GIS) and a relational data-base known as LARA (the Lincoln Archaeological Research Assessment).
    Keywords: Social Science ; Archaeology ; History ; Europe ; Great Britain ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Rituals in Slavic Pre-Christian Religion (2023)
    Arc Humanities Press
    Details
    Publication Date: 2024-04-14
    Description: The authors comprehensively analyze all the available information regarding the ritual practices of Slavic pre-Christian religion that can be found in written medieval texts. After investigating every kind of reference to such practices, they offer a reconstruction of Slavic pre-Christian religion on the basis of these medieval testimonies. In doing so, they overcome the challenges presented by the fact that all of these sources are indirect, since the Slavs did not acquire literacy until they became Christians. Thus the writers of these texts mostly professed a monotheistic religion, being Christians and in some cases Muslims. The picture that they offer is biased and determined by their own faith. The present analysis innovatively combines testimonies from every Slavic area (Eastern, Western, and Southern), showing their mutual correspondences and emphasizing the relationship between the Slavic pre-Christian religion and its Indo-European roots.
    Keywords: Slavic peoples;Baltic peoples;folklore;pagan religions;early Middle Ages ; thema EDItEUR::V Health, Relationships and Personal development::VX Mind, body, spirit::VXW Mysticism, magic and occult interests::VXWS Shamanism, paganism and Druidry ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBG Popular beliefs and controversial knowledge::JBGB Folklore studies / Study of myth (mythology) ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFF Historical and comparative linguistics
    Language: English
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    Global health issues of aflatoxins in food and agriculture: Challenges and opportunities (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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    Austrian Studies Today (2023)
    University of New Orleans Press
    Details
    Publication Date: 2024-04-02
    Description: This volume celebrates the study of Austria in the twentieth century by historians, political scientists and social scientists produced in the previous twenty-four volumes of Contemporary Austrian Studies. One contributor from each of the previous volumes has been asked to update the state of scholarship in the field addressed in the respective volume. The title Austrian Studies Today, then, attempts to reflect the state of the art of historical and social science related studies of Austria over the past century, without claiming to be comprehensive. The volume thus covers many important themes of Austrian contemporary history and politics since the collapse of the Habsburg Monarchy in 1918―from World War I and its legacies, to the rise of authoritarian regimes in the 1930s and 1940s, to the reconstruction of republican Austria after World War II, the years of Grand Coalition governments and the Kreisky era, all the way to Austria joining the European Union in 1995 and its impact on Austria's international status and domestic politics.
    Keywords: History ; Political Science ; European Studies ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    Emerging Materials for Additive Manufacturing (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Ceramics and the Spanish Conquest (2021)
    Brill
    Details
    Publication Date: 2024-03-23
    Description: The Spanish colonization dramatically interrupted the autonomous development of ancient Mesoamerican culture. Nevertheless, indigenous societies learnt to live with the conquest. It was not only a time of crisis, but also an extraordinarily creative time period in which material culture reflected indigenous peoples’ varied responses and adaptations to the changing circumstances. This work presents insights into the process of cultural continuity and change in the indigenous world by focusing on pottery technology in the Nahua (Aztec) region of Central Mexico. The late pre-colonial, early colonial and present-day characteristics of this industry are explored in order to come to a renewed understanding of its long-term development.
    Keywords: material culture ; colonial ceramics ; spanish conquest ; ceramic technology ; colonial mesoamerica ; cultural continuity ; ethnographic ceramics ; colonialism ; ceramics ; Aztecs ; Clay ; Mexico ; Pottery ; Pre-Columbian era ; Race and ethnicity in the United States Census ; Valley of Mexico ; thema EDItEUR::1 Place qualifiers::1K The Americas::1KL Latin America – Mexico, Central America, South America::1KLC Mexico and Central America::1KLCM Mexico ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Marine Compounds and Cancer (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Language: English
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    Chapter Material Culture (2023)
    Taylor & Francis | The Hispanic-Anglosphere from the Eighteenth to the Twentieth Century | Routledge
    Details
    Publication Date: 2024-04-02
    Description: The Hispanic and Anglo worlds are often portrayed as the Cain and Abel of Western culture, antagonistic and alien to each other. This book challenges such view with a new critical conceptual framework – the ‘Hispanic-Anglosphere’ – to open a window into the often surprising interactions of individuals, transnational networks and global communities that, it argues, made of the British Isles (England, Ireland, Scotland, Wales, the Channel Islands and the Isle of Man) a crucial hub for the global Hispanic world, a launching-pad and a bridge between Spanish Europe, Africa, America and Asia in the late eighteenth to the early twentieth centuries. Perhaps not unlike today, that was a time marked by social uncertainty, pandemics, the dislocation of global polities and the rise of radicalisms. The volume offers insights on many themes including trade, the arts, education, language, politics, the press, religion, biodiversity, philanthropy, anti-slavery and imperialism. Established academics and rising stars from different continents and disciplines combined original, primary research with a wide range of secondary sources to produce a rich collection of ten case-studies, 25 biographies and seven samples of interpreted material culture, all presented in an accessible style appealing to scholars, students and the general reader alike.
    Keywords: Anti-slavery, Biodiversity, Hispanic-anglosphere, Philanthropy ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Personalized Medicine for Parkinson's Disease (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
    Language: English
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    Urological Cancer 2022 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Epigenetics of B Cells and Antibody Responses (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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    Feminist Approaches to Early Medieval English Studies (2023)
    Amsterdam University Press
    Details
    Publication Date: 2024-04-02
    Description: Scholarship on early medieval England has seen an exponential increase in scholarly work by and about women over the past twenty years, but the field has remained peculiarly resistant to the transformative potential of feminist critique. Since 2016, Medieval Studies has been rocked by conversations about the state of the field, shifting from #MeToo to #WhiteFeminism to the purposeful rethinking of the label “Anglo-Saxonist.” This volume takes a step toward decentering the traditional scholarly conversation with thirteen new essays by American, Canadian, European, and UK professors, along with independent scholars and early career researchers from a range of disciplinary perspectives. Topics range from virginity, women’s literacy, and medical discourse to affect, medievalism, and masculinity. The theoretical and political commitments of this volume comprise one strand of a multivalent effort to rethink the parameters of the discipline and to create a scholarly community that is innovative, inclusive, and diverse.
    Keywords: Medieval, Old English, women, gender ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls::JBSF11 Feminism and feminist theory
    Language: English
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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    Creative Spaces (2021)
    University of London Press | University of London Press
    Details
    Publication Date: 2024-04-01
    Description: Creative Spaces: Urban Culture and Marginality is an interdisciplinary exploration of the different ways in which marginal urban spaces have become privileged locations for creativity in Latin America. The essays within the collection reassess dominant theoretical notions of ‘marginality’ in the region and argue that, in contemporary society, it invariably allows for (if not leads to) the production of the new. While Latin American cities have, since their foundation, always included marginal spaces (due, for example, to the segregation of indigenous groups), the massive expansion of informal housing constructed on occupied land in the second half of the twentieth century have brought them into the collective imaginary like never before. Originally viewed as spaces of deprivation, violence, and dangerous alterity, the urban margins were later romanticized as spaces of opportunity and popular empowerment. Instead, this volume analyses the production of new art forms, political organizations and subjectivities emerging from the urban margins in Latin America, neither condemning nor idealizing the effects they produce. To account for the complex nature of contemporary urban marginality, the volume draws on research from a wide spectrum of disciplines, ranging from cultural and urban studies to architecture and sociology. Thus the collection analyzes how these different conceptions of marginal spaces work together and contribute to the imagined and material reality of the wider city.
    Keywords: marginality ; liminality ; urbanity ; diaspora ; migration ; population ; History ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Immune responses to AAV vectors, from bench to bedside (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
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    Music and the Making of Portugal and Spain (2023)
    University of Illinois Press
    Details
    Publication Date: 2024-04-02
    Description: How music embodies and contributes to historical and contemporary nationalism What does music in Portugal and Spain reveal about the relationship between national and regional identity building? How do various actors use music to advance nationalism? How have state and international heritage regimes contributed to nationalist and regionalist projects? In this collection, contributors explore these and other essential questions from a range of interdisciplinary vantage points. The essays pay particular attention to the role played by the state in deciding what music represents Portuguese or Spanish identity. Case studies examine many aspects of the issue, including local recording networks, so-called national style in popular music, and music’s role in both political protest and heritage regimes. Topics include the ways the Salazar and Franco regimes adapted music to align with their ideological agendas; the twenty-first-century impact of UNESCO’s Intangible Cultural Heritage program on some of Portugal and Spain's expressive practices; and the tensions that arise between institutions and community in creating and recreating meanings and identity around music. Contributors: Ricardo Andrade, Vera Marques Alves, Salwa El-Shawan Castelo-Branco, Cristina Sánchez-Carretero, José Hugo Pires Castro, Paulo Ferreira de Castro, Fernán del Val, Héctor Fouce, Diego García-Peinazo, Leonor Losa, Josep Martí, Eva Moreda Rodríguez, Pedro Russo Moreira, Cristina Cruces Roldán, and Igor Contreras Zubillaga
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Racism in Modern Russia (2022)
    Bloomsbury Academic | Bloomsbury Academic
    Details
    Publication Date: 2024-04-02
    Description: In October 2013, one of the largest anti-migrant riots took place in Moscow. Clashes and arrests continued late into the night. Some in the crowd, which grew to several thousand people, could be heard chanting “Russia for the Russians” with their animus directed towards dark-skinned labor migrants from the southern border. The slogan “Russia for the Russians” is not a recent invention. It first gained notoriety in the very last years of the tsarist regime, appealing primarily to individuals drawn to the radical right. Analyzing a wide range of printed and visual sources, Racism in Modern Russia marks the first serious attempt to understand the history of racism over a span of 150 years. A brilliant examination of the complexities of racism, Eugene M. Avrutin’s panoramic book asks powerful questions about inequality and privilege, denigration and belonging, power and policy, and the complex historical links between race, whiteness, and geography. The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 license on www.bloomsburycollections.com.
    Keywords: Society ; culture ; racial studies ; race ; prejudice ; hate crimes ; modern history ; Russian history ; social history ; discrimination ; anti-racism ; anti-racist ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MR 21st century, c 2000 to c 2100
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    Afghanistan’s Islam: From Conversion to the Taliban (2021)
    University of California Press
    Details
    Publication Date: 2024-04-02
    Description: This book provides the first overview of the history and development of Islam in Afghanistan. Written by leading international experts, chapters cover every era from the conversion of Afghanistan through the medieval period to the present day. Based on primary sources in Arabic, Persian, Pashto, Uzbek, and Urdu, its depth of coverage is unrivalled in providing a developmental picture of Afghanistan’s Islam, including such issues as the rise of Sufism, women’s religiosity, state religious policies, and transnational Islamism. Looking beyond the unifying rhetoric of theology, the book reveals the disparate and contested forms of Afghanistan’s Islam.
    Keywords: islam ; muslims ; afghanistan ; Herat ; Naqshbandi ; Pashtuns ; Sufism ; Timurid dynasty ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general
    Language: English
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    How Intelligence Can Be a Solution to Consequential World Problems (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-01
    Description: Intelligence research is mainly concerned with basic science questions; what is the psychometric structure of intelligence? What are the cognitive bases of intelligence? What are the brain-based correlates of intelligence? What does intelligence predict? Such research is needed, but there are also problems larger than those presented in intelligence tests, including problems of today. What is the role of human intelligence in solving consequential real-world problems? Here, leading scholars in the field of intelligence each address one real-world problem—a problem of their choice—and explain how intelligence has been, or could be, essential for a solution.
    Keywords: intelligence ; IQ ; giftedness ; transactional giftedness ; transformational giftedness ; critical thinking ; real-world problems ; innovation ; talent selection and development ; gifted education ; social returns ; cognitive aptitudes and creativity ; grand societal challenges ; Sustainable Development Goals ; complex problems ; consequential world problems ; mental tests ; cognitive ageing ; cognitive epidemiology ; mortality ; cognitive development ; wisdom ; education ; conflict resolution ; problem-solving ; decision making ; history-wars ; Wechsler scales ; WAIS-IV ; federal judges ; Supreme Court ; fluid reasoning ; processing speed ; crystallized knowledge ; working memory ; aging-IQ research ; computerized adaptive testing ; test construction ; collective intelligence ; metacognition ; wellbeing ; inequity ; social issues ; functional literacy ; job complexity ; nonadherence to treatment ; noncommunicable disease ; diabetes ; diabetes self-management ; behavioral risk factors ; global burden of disease ; epidemiological transition ; social movements ; theory of social change, cultural evolution, and human development ; social intelligence ; practical intelligence ; abstract intelligence ; COVID-19 ; cultural evolution ; adaptive intelligence ; George Floyd protests ; higher-order thinking ; real-world environments ; infectious diseases ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues
    Language: English
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    Chapter 4 Quarantine in Ceuta and Malta in the travel writings of the late-eighteenth-century Moroccan ambassador Ibn Uthmân Al-Meknassî (2021)
    Manchester University Press | Mediterranean quarantines, 1750–1914: Space, identity and power
    Details
    Publication Date: 2024-04-02
    Description: This chapter examines the writings of the renowned late-eighteenth-century Moroccan ambassador Ibn Uthmân Al-Meknassî, the first known traveller from his country to leave an account of European quarantine as experienced during his two diplomatic missions in Spain’s Ceuta (1779) and Malta’s Valletta (1782). It shows that quarantine, on the one hand, acted as a marker of otherness by which Ibn Othman was identified as a Muslim, though this was not a uniform process, owing to the fact that significant differences existed in the degree of alterity experienced in Spain and Malta, and indeed other parts of the Mediterranean. The subjective opinion on quarantine, on the other hand, was also one of the means through which Ibn Uthmân situated himself within Makhzen (Moroccan government) elites at a time when a division between those who declared themselves in favour of European-style modernisation and those who advocated a rejection of European novelties was already visible.
    Keywords: ibn uthmân al-meknassî ; spain ; diplomatic missions ; morocco ; 18th century ; quarantine ; malta ; muslim identity ; ibn uthmân al-meknassî ; spain ; diplomatic missions ; morocco ; 18th century ; quarantine ; malta ; muslim identity ; Ceuta ; Epidemic ; Mediterranean Sea ; Tangier ; Travel literature ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine
    Language: English
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    History without Chronology (2021)
    Lever Press
    Details
    Publication Date: 2024-04-01
    Description: Although numerous disciplines recognize multiple ways of conceptualizing time, Stefan Tanaka argues that scholars still overwhelmingly operate on chronological and linear Newtonian or classical time that emerged during the Enlightenment. This short, approachable book implores the humanities and humanistic social sciences to actively embrace the richness of different times that are evident in non-modern societies and have become common in several scientific fields throughout the twentieth century. Tanaka first offers a history of chronology by showing how the social structures built on clocks and calendars gained material expression. Tanaka then proposes that we can move away from this chronology by considering how contemporary scientific understandings of time might be adapted to reconceive the present and pasts. This opens up a conversation that allows for the possibility of other ways to know about and re-present pasts. A multiplicity of times will help us broaden the historical horizon by embracing the heterogeneity of our lives and world via rethinking the complex interaction between stability, repetition, and change. This history without chronology also allows for incorporating the affordances of digital media.
    Keywords: history ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    Civic Spaces and Desire (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2024-04-01
    Description: Civic Spaces and Desire presents an original and critical appraisal of civic spaces for a novel theoretical intersection of architecture and human geography. The authors address civic spaces that embody a strong moral code, such as a remembrance park or a casino, in various places in the United Kingdom, Europe, North America, Australia and Asia. The consecutive chapters of the book present these chosen spaces as the interconnection between the everyday and the ideological. By doing so the book reimagines the socio-political effects of the countercultural assemblages and ontologies of difference that these spaces produce, represent and foster, as presented through outcasts and nomads of various kinds and forms. The book reflects on different interpretations of the key texts from primarily post-linguistic theoreticians, such as Gilles Deleuze, Félix Guattari and Jacques Derrida. It will benefit students and academics in architecture, geography, philosophy and urban studies and planning, who seek to understand the politics of space, place and civility. By deconstructing normative ideological constructs, the book uses the concept of desire to explore the tensions between expectations of civic spaces and the disappointment and wonder of their immanent existence.
    Keywords: civic spaces ; architecture ; human geography ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    The System of the Inquisition in Medieval Europe (2021)
    Peter Lang International Academic Publishing Group
    Details
    Publication Date: 2024-04-01
    Description: This book reexamines the origins and growth of the medieval inquisition which provided a framework for the large-scale operations against religious dissidents. In the last quarter of the twelfth century, the papacy launched concerted efforts to hunt out heretics, mostly Cathars and Waldensians, and directed operations against them all across Latin Christendom. The bull of Pope Lucius III Ad abolendam of 1184 became a turning point in the formation of the inquisitorial system which made both the clergy and the laity responsible for suppressing any religious dissent. From a comparative perspective, the study analyzes political, social and religious developments which in the High Middle Ages gave birth to the mechanism of repression and religious violence supervised by the papacy and operated by bishops and, starting from the 1230s, papal inquisitors, extraordinary judges delegate staffed mostly by Dominican and Franciscan friars.
    Keywords: Europe ; Heresy ; Heresy trials ; Inquisition ; Inquisitorial registers ; Kras ; Medieval ; Medieval Christendom ; Religious violence ; System ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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    The Eve of Spain (2022)
    Johns Hopkins University Press
    Details
    Publication Date: 2024-04-02
    Description: The Eve of Spain demonstrates how the telling and retelling of one of Spain’s founding myths played a central role in the formation of that country’s national identity. King Roderigo, the last Visigoth king of Spain, rapes (or possibly seduces) La Cava, the daughter of his friend and counselor, Count Julian. In revenge, the count travels to North Africa and conspires with its Berber rulers to send an invading army into Spain. So begins the Muslim conquest and the end of Visigothic rule. A few years later, in Northern Spain, Pelayo initiates a Christian resistance and starts a new line of kings to which the present-day Spanish monarchy traces its roots.Patricia E. Grieve follows the evolution of this story from the Middle Ages into the modern era, as shifts in religious tolerance and cultural acceptance influenced its retelling. She explains how increasing anti-Semitism came to be woven into the tale during the Christian conquest of the peninsula—in the form of traitorous Jewish conspirators. In the sixteenth century, the tale was linked to the looming threat of the Ottoman Turks. The story continued to resonate through the Enlightenment and into modern historiography, revealing the complex interactions of racial and religious conflict and evolving ideas of women’s sexuality.In following the story of La Cava, Rodrigo, and Pelayo, Grieve explains how foundational myths and popular legends articulate struggles for national identity. She explores how myths are developed around few historical facts, how they come to be written into history, and how they are exploited politically, as in the expulsion of the Jews from Spain in 1492 followed by that of the Moriscos in 1609. Finally, Grieve focuses on the misogynistic elements of the story and asks why the fall of Spain is figured as a cautionary tale about a woman’s sexuality.
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Chapter Tra reale e virtuale: il medievale castello di Mussomeli (2022)
    FrancoAngeli
    Details
    Publication Date: 2024-04-16
    Description: The 43rd UID conference, held in Genova, takes up the theme of ‘Dialogues’ as practice and debate on many fundamental topics in our social life, especially in these complex and not yet resolved times. The city of Genova offers the opportunity to ponder on the value of comparison and on the possibilities for the community, naturally focused on the aspects that concern us, as professors, researchers, disseminators of knowledge, or on all the possibile meanings of the discipline of representation and its dialogue with ‘others’, which we have broadly catalogued in three macro areas: History, Semiotics, Science / Technology. Therefore, “dialogue” as a profitable exchange based on a common language, without which it is impossible to comprehend and understand one another; and the graphic sign that connotes the conference is the precise transcription of this concept: the title ‘translated’ into signs, derived from the visual alphabet designed for the visual identity of the UID since 2017. There are many topics which refer to three macro sessions: - Witnessing (signs and history) - Communicating (signs and semiotics) - Experimenting (signs and sciences) Thanks to the different points of view, an exceptional resource of our disciplinary area, we want to try to outline the prevailing theoretical-operational synergies, the collaborative lines of an instrumental nature, the recent updates of the repertoires of images that attest and nourish the relations among representation, history, semiotics, sciences.
    Keywords: Discipline of representation, History, Semiotics, Science, Technology ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTD Semiotics / semiology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: Italian , English
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    Marine Natural Products as Anticancer Agents 2.0 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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