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  • thema EDItEUR::N History and Archaeology::NH History::NHD European history  (1,086)
  • bic Book Industry Communication::M Medicine  (1,000)
  • bic Book Industry Communication::J Society & social sciences::JP Politics & government  (773)
  • English  (2,383)
  • French  (446)
  • Dutch  (28)
  • Russian  (9)
  • 2020-2024  (2,856)
Collection
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  • 1
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    Johns Hopkins University Press
    Publication Date: 2024-04-02
    Description: This book reviews the course of NATO policy on German reunification from the perspective of West German preferences and Bonn's endeavors to have them respected in the diplomatic efforts of the major allies. With its accession to NATO, the West German government under Adenauer continued its policy of rehabilitating the German people in the eyes of the Western political community by playing a willing and sometimes leading role in joint ventures whose purpose was said to transcend the nation-state.
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 2
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    Central European University Press
    Publication Date: 2024-04-02
    Description: With forty-two extensively annotated maps, this atlas offers novel insights into the history and mechanics of how Central Europe’s languages have been made, unmade, and deployed for political action. The innovative combination of linguistics, history, and cartography makes a wealth of hard-to-reach knowledge readily available to both specialist and general readers. It combines information on languages, dialects, alphabets, religions, mass violence, or migrations over an extended period of time. The story first focuses on Central Europe’s dialect continua, the emergence of states, and the spread of writing technology from the tenth century onward. Most maps concentrate on the last two centuries. The main storyline opens with the emergence of the Western European concept of the nation, in accord with which the ethnolinguistic nation-states of Italy and Germany were founded. In the Central European view, a “proper” nation is none other than the speech community of a single language. The Atlas aspires to help users make the intellectual leap of perceiving languages as products of human history and part of culture. Like states, nations, universities, towns, associations, art, beauty, religions, injustice, or atheism—languages are artefacts invented and shaped by individuals and their groups.
    Keywords: Ethnolinguistics, Nation states, Language politics, Nationalism, Sociolinguistics, Areal linguistics ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology
    Language: English
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  • 3
    Publication Date: 2024-04-02
    Description: Henri Hours' book on the end of the League in Lyon is one of the most important works of 16th century historiography in Lyon, although very few readers have had the opportunity to consult it. This is its main paradox and the challenge of this edition. The thesis was defended at the École Nationale des Chartes in 1951, but it has never been published and, in accordance with the rules of the École, it has never been made available. Only those who knew the author were able to read it, which does not prevent it from appearing in all bibliographies concerning the Wars of Religion. Following his death in 2017 and with the agreement of his family, the Collection Chrétiens & Sociétés has decided to publish this memoir for the first time in order to make it accessible to the public in Lyon and to historians of religious confrontations. Henri Hours meticulously analysed the last years of the League at Lyon, the crucial years 1593-1597. Since 1589, the city had swayed to the side of Catholic intransigence to the point of rejecting its sovereign, Henry IV, and maintaining a costly but necessary war effort in a region crossed by denominational borders. The bishop, Pierre d'Epinac, the consuls of Lyon, the governor of the city, the Savoyard and Spanish spies, but also the street preachers and the little people who were very inclined to be alarmed, were the main actors in these events. Here we touch on the political and religious dimensions of urban history. Through municipal deliberations, correspondence, pamphleteering and some contemporary accounts, Henri Hours unravels the skein of the city's political shift towards submission to the king. By looking back at the writings of some of these actors, notably Pierre Mathieu and Claude de Rubys, he also questions the memory of the event in the consciousness of Lyon.
    Keywords: Lyon ; Wars of religion ; Religion's War ; Urban History ; Violence ; Debt ; Coexistence ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 5
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 6
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    Presses universitaires de Perpignan
    Publication Date: 2024-04-02
    Description: Les auteurs de cet ouvrage “ Pierre et Archéologie ”, issu du Colloque international qui s’est tenu à Tautavel (14-15 mai 1998) veulent attirer l’attention sur les nombreux aspects de l’utilisation de la pierre par l’Homme depuis la Préhistoire, et les difficultés pour comprendre et expliquer son identification, son évolution et sa conservation. Mise à part l’utilisation lointaine de la pierre par l’homme préhistorique pour assurer sa survie, il reste le domaine très vaste, plus récent dans le temps, de la pierre de taille utilisée par les hommes. Déjà les gallo-romains se sont servis des pierres dites « du midi » pour des constructions que nous connaissons bien. Mais la pierre n’est pas réservée seulement aux monuments, elle fait partie de la vie quotidienne. En dehors des grands édifices, de nombreuses habitations sont bâties en pierre et souvent leur sol est pavé de pierres. Il y a aussi l’amour de la pierre tout simplement, pour le beau, le toucher : c’est par exemple la sculpture qui agrémente les monuments et même les habitations. Les sarcophages en marbre blanc, sculptés entre la fin de l’Antiquité classique et le Haut Moyen-Age, dont le problème de l’origine est traité dans cet ouvrage, montrent bien la diversité des aspects artistiques que l’Homme a su exploiter. L’ensemble des contributions présentées apporte des données originales sur les méthodes et techniques modernes utilisées pour contribuer à mieux comprendre l’évolution culturelle et artistique de l’humanité, le devenir de la pierre extraite et la restauration des monuments. Ceci montre une fois de plus la nécessité d’une recherche pluridisciplinaire, seule démarche pour assurer la protection et la pérennité de tout ce qui touche notre patrimoine.
    Keywords: histoire ; carrière ; pierre ; outil préhistorique ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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  • 7
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    EPURE, Éditions et presses universitaires de Reims
    Publication Date: 2024-04-02
    Description: In recent years, through novels and television series ("Vikings", "Millennium", "Borgen" or "Occupied"), Nordic culture has become more visible internationally. At the same time, researchers are questioning what the North is, its conceptualisation, its cultural implications, its geographical characteristics, its social and political challenges. This volume is part of the current debate on the Nordic imaginary based on a notion, Nordicity, which intersects with borealism. Plural and mobile, the North inspires both scriptural and figurative production based on desire, dream, fascination or fantasy. The real, tangible and contingent North is only the apparent surface of a manufactured and invented North. How can we express northernness today? Is a theory of the North possible? This volume attempts to answer these questions by bringing together contributions from researchers in Nordic studies, literature, linguistics and the humanities: each is given the opportunity to define his own conception of Nordicity. Ces dernières années, à travers romans et sériés télévisées ("Vikings", "Millennium", "Borgen" ou "Occupied"), la culture nordique a gagné en visibilité internationale. Simultanément, les chercheurs s'interrogent sur ce qu’est le Nord, sa conceptualisation, ses implications culturelles, ses caractéristiques géographiques, ses enjeux sociaux et politiques. Ce volume s’insère dans le débat actuel sur l’imaginaire nordique à partir d’une notion – la nordicité – qui interagit tout particulièrement avec le boréalisme. Pluriel et mouvant, moteur constant de redéfinitions, le Nord inspire une fabrication tant scripturale que figurale fondée sur le désir, le rêve, la fascination ou le fantasme. Le Nord réel, tangible contingent, n’est que la surface apparente d’un Nord fabriqué et inventé. Comment dire aujourd’hui la nordicité? Une théorie du Nord est-elle possible? Ce volume s’attache à répondre à ces différentes questions en réunissant les contributions de chercheurs en études nordiques, littérature, linguistique ou sciences humaines: chacun dispose ici d’une carte blanche pour définir sa conception de la nordicité.
    Keywords: Nordicity ; Scandinavia ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::1 Place qualifiers::1D Europe::1DN Northern Europe, Scandinavia ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages::2AC Germanic and Scandinavian languages::2ACS Scandinavian languages ; thema EDItEUR::2 Language qualifiers::2A Indo-European languages::2AC Germanic and Scandinavian languages::2ACB English::2ACBC Middle English
    Language: French , English
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  • 8
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    ANU Press
    Publication Date: 2022-04-28
    Description: Government policy; Social conditions; Aboriginal australians
    Keywords: government policy ; social conditions ; aboriginal australians ; Census ; Community Development Employment Projects ; Darwin ; Northern Territory ; Indigenous Australians ; Northern Territory ; Wadeye ; Northern Territory ; Workforce ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 9
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    Taylor & Francis | Routledge
    Publication Date: 2024-03-29
    Description: "The Politics of Trauma and Integrity uses the lenses of gender and trauma to tell the stories of narratives testified by two contrasting Japanese “comfort women” survivors. Through an innovative interdisciplinary study of the politics of gendered memory and trauma in historical context, with numerous primary sources for analysis including diaries, interviews, letters and oral testimonies, this book uncovers the life-or-death struggles of Japanese survivors in pursuit of public recognition as the victims of state violence against women. It is set within a gender history of modern Japan, supplemented by feminist activist methodology premised upon political agency that seeks social justice. The author’s analysis draws upon three key concepts: trauma, coherence of the self, and integrity. Focusing upon the role of gender and trauma as the nexus between memory construction and identity formation in modern Japan, the author reveals these women’s relentless quest for their recovery and creation of new identities. This book provides a better understanding of the victims of sexual violence and encourages readers to listen to the voice of trauma, as well as making a significant contribution to the existing research on the ongoing history of sexual violence against women in Japan, the rest of Asia and beyond. It will be of interest to scholars, researchers, activists and all who are interested in the issue of women’s human rights. It provides supplementary reading and research material for history and politics courses relating to Japan and East Asia, memory, identity, trauma, gender, war and feminist activism. This book will also be beneficial to victims of sexual violence as well as the counsellors/psychologists engaging with them."
    Keywords: Activist, Comfort Woman, Comfort Women, Conspiracy, Feminist, Gender, Human Right, Identity, Integrity, Japan, Kikumaru, Listener, Masculinity, Memory, Patriarchal, Politics, Recovery, Revisionism, Self, Sex, Shirota, Silence, Social Justice, State, Survivor, Trauma, Victim, Violence, War ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English , Japanese
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  • 10
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 11
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    University of Michigan Press | University of Michigan Press
    Publication Date: 2024-04-02
    Description: "Printing and Prophecy: Prognostication and Media Change 1450-1550 examines prognostic traditions and late medieval prophetic texts in the first century of printing and their effect on the new medium of print. The many prophetic and prognostic works that followed Europe's earliest known printed book—not the Gutenberg Bible, but the Sibyl's Prophecy, printed by Gutenberg two years earlier and known today only from a single page—over the next century were perennial best sellers for many printers, and they provide the modern observer with a unique way to study the history and inner workings of the print medium. The very popularity of these works, often published as affordable booklets, raised fears of social unrest. Printers therefore had to meet customer demand while at the same time channeling readers' reactions along approved paths. Authors were packaged—and packaged themselves—in word and image to respond to the tension, while leading figures of early modern culture such as Paracelsus, Martin Luther, and Sebastian Brant used printed prophecies for their own purposes in a rapidly changing society. Based on a wide reading of many sources, Printing and Prophecy contributes to the study of early modern literature, including how print changed the relationship among authors, readers, and texts. The prophetic and astrological texts the book examines document changes in early modern society that are particularly relevant to German studies and are key texts for understanding the development of science, religion, and popular culture in the early modern period. By combining the methods of cultural studies and book history, this volume brings a new perspective to the study of Gutenberg and later printers."
    Keywords: History ; Astrology ; Latin ; Lichtenberger ; Practica (astrology) ; Prophecy ; Woodcut ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 12
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-07
    Description: This edited volume explores a variety of aspects of associative governance, providing detailed case studies of associations and associational governance in Scandinavia. Theoretically developing a concept and approach of associative governance, the book sheds light on a dynamic way of perceiving associative aspects of community and commercial life that has been hitherto underexplored and undertheorized. It shows how governance by associations may be conducted not only bottom‑up by self‑organized and voluntary participation, but also top‑down by authoritative incorporation through government, and – not least – in multifarious interstices in between. New section by exploring a vibrant panoply of dimensions of associative governance, empirically grounded in historical analyses of a wide range of organizational repertoires, the book may provide novel insights into the significant role of associative governance in Scandinavia over the past two centuries. Finally, it provides research‑based knowledge about how to maintain “good political and economic institutions” in the future and a more holistic and dynamic approach to the literature on The Nordic model. The book will be of key interest to scholars and students of Nordic and Scandinavian studies, history, sociology, political science, marketing, social policy, organization theory, and public management. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution‑Non Commercial‑No Derivatives (CC‑BY‑NC‑ND) 4.0 license.
    Keywords: Nordic societies ; Scandinavia ; governance ; Scandinavian societies ; Nordic governance ; associative governance ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTM Regional / International studies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJU Organizational theory and behaviour ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 14
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders;celiac disease;gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 16
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 17
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    Presses universitaires François-Rabelais
    Publication Date: 2024-04-02
    Description: Comment les consommateurs arbitrent entre santé et plaisir, nutrition et saveur, bienséance et confort, croyance et science, tempérament et pression sociale, innovation et habitude, ou encore considérations éthiques et servitudes quotidiennes. Quelle légitimité accordent-ils aux paroles d’interlocuteurs venant d’horizons divers - de la médecine à la publicité, du gouvernement à la philanthropie - et qui diffusent messages et recommandations concernant la nourriture et l’hygiène de vie ? Ce sont les questions qui animent ce livre. Les chapitres contribuent à la restitution de l’univers informationnel des consommateurs depuis le XIVe au XXe siècle. Ils s’attachent à décrire et expliquer l’émergence et le fonctionnement des repères qui permettent de nous orienter dans les marchés alimentaires et des services qui s’y rattachent. Les thèmes concernent l’identification des produits et de leurs caractéristiques, l’imagination liée à l’alimentation et à la cuisine, et l’intervention des autorités publiques dans les transactions alimentaires.
    Keywords: histoire ; alimentation ; histoire contemporaine ; histoire moderne ; cuisine ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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  • 18
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 19
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    Society for Libyan Studies | Society for Libyan Studies
    Publication Date: 2024-04-02
    Description: The buildings erected in his native city by the Roman emperor Septimius Severus are amongst the most impressive and best-preserved in the Roman world. Because of their unique state of preservation, they give an unparalleled insight into what an architect with an imperial commission could do, when he had the building-materials and technical expertise of the entire empire at his disposal.〈br/>〈br/>The buildings excavated by Italian teams between the two World Wars were examined in detail by Ward-Perkins between 1948 and 1953. The study was never completed in his lifetime, though the drawings and much of the text existed at least in draft form. The present publication puts these in the public domain, together with Ward-Perkins' authoritative insights into the process by which such a grand project was executed.
    Keywords: History ; Ancient ; Rome ; Social Science ; Archaeology ; Architecture ; History ; Ancient & Classical ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::A The Arts::AM Architecture::AMX History of architecture
    Language: English
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    Historic England | Historic England
    Publication Date: 2024-03-23
    Description: St Peter's, Barton-upon-Humber, is a redundant medieval church in the care of English Heritage. As a result of a major program of research carried out between 1978 and 2007, it is now the most intensively studied parish church in the UK. Excavations between 1978 and 1984 investigated most of the interior of the building, as well as a swathe of churchyard around its exterior. At the same time, a stone-by-stone record and detailed archaeological study of the fabric and furnishings of the church was undertaken, continuing down to 2007. The twin aims of the project were to understand the architectural history and setting of this complex, multi-period building (Volume 1, Parts 1 and 2) and to recover a substantial sample of the population for palaeopathological study (Volume 2). An extensive program of historical and topographical research also took place in order to set the archaeological evidence firmly in context.
    Keywords: Architecture ; History ; History ; Europe ; Medieval ; History ; Europe ; Great Britain ; thema EDItEUR::A The Arts::AM Architecture::AMX History of architecture ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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    Presses universitaires de Rennes
    Publication Date: 2022-07-01
    Description: Ce livre est un hommage à Jean Baudouin, professeur émérite de science politique qui achève sa carrière après quatre décennies d’enseignement et de recherche à l’université Rennes 1. Après une introduction qui présente son itinéraire et son apport à la science politique française, ses collègues, amis et élèves abordent les grands domaines et les principales thématiques qui ont occupé sa pensée. Les contributions de ce volume s’organisent autour de trois parties. La première, qui porte sur les radicalités politiques, explore principalement le phénomène communiste, envisagé dans ses dimensions nationale et mondiale, tout en offrant également de nouvelles perspectives sur les évolutions récentes de l’extrême gauche et l’engagement frontiste. La deuxième partie, centrée sur la question de la démocratie libérale, associe l’étude d’auteurs classiques à un questionnement conceptuel qui vient éclairer l’actualité la plus brûlante concernant la démocratie, la place du religieux ou encore la situation de l’Union européenne. La troisième partie vient enfin contribuer à l’étude de l’engagement des intellectuels en politique, en attirant l’attention sur des figures aussi différentes que Charles Fourier, Louis Aragon, Francis Delaisi, Emmanuel Mounier, Michel Foucault ou les intellectuels maoïstes. L’ensemble se clôt sur la reprise d’un article important de Jean Baudouin, datant de 1997 et devenu aujourd’hui introuvable, précisant la conception du politique défendue par ce professeur au positionnement singulier. Cet ouvrage entend ainsi offrir au lecteur une vue panoramique sur un courant dynamique de la science politique française – la théorie politique – dont il a été l’un des principaux animateurs et dont il reste l’un des plus éminents représentants. Cet ouvrage rassemble les contributions de Jean Baudouin, Philippe Bénéton, David Bisson, Goulven Boudic, Daniel Bourmaud, Philippe Braud, Bernard Bruneteau, Sébastien Caré, Gwendal Châton, Stéphane Courtois, Jean-Marie Donégani, Michel Hastings, François Hourmant, Marc Lazar, Arnauld Leclerc, Jacques Le Goff, Pascal Perrineau, Philippe Portier, Philippe Raynaud et Thuriane Séveno. Sa publication a bénéficié du soutien de l’Institut du droit public et de la science politique (IDPSP) de l’université Rennes 1, ainsi que de la faculté de droit et de science politique.
    Keywords: communisme ; politique ; démocratie ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: French
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-03-16
    Description: This book discusses and analyses global policies and practices aimed at promoting equity in higher education participation and attainment. Although the massification of higher education systems has facilitated the participation of students from deprived backgrounds, socioeconomic inequalities persist in access to the most prestigious institutions and programmes. Privileged students benefit from a number of advantages in the competition for selective and scarce places: access to information, lower aversion to debt, higher expectations, better previous schooling and higher academic achievement. The chapters present a critical analysis of equity policies in different countries – with or without affirmative action policies, within a context of neoliberal policies or within a social democratic model – and the reasons why they have failed to promote equity and fairness, preventing students from achieving their full educational potential. This is an open access book.
    Keywords: equity in higher education ; access to higher education ; participation in higher education ; attainment and retention ; higher education policy ; Open Access ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-02
    Description: Back in 1989, many anticipated that the end of the Cold War would usher in the ‘end of history’ characterized by the victory of democracy and capitalism. At the thirtieth anniversary of this momentous event, this book challenges this assumption. It studies the most recent era of contemporary European history in order to analyse the impact, consequences and legacy of the end of the Cold War for Western Europe. Bringing together leading scholars on the topic, the volume answers the question of how the end of the Cold War has affected Western Europe and reveals how it accelerated and reinforced processes that shaped the fragile (geo-)political and economic order of the continent today. In four thematic sections, the book analyses the changing position of Germany in Europe; studies the transformation of neoliberal capitalism; answers the question how Western Europe faced the geopolitical challenges after the Berlin Wall came down; and investigates the crisis of representative democracy. As such, the book provides a comprehensive and novel historical perspective on Europe since the late 1980s.
    Keywords: Central and Eastern Europe ; Cold War ; End of Communism ; End of History ; Fall of the Berlin Wall ; Free Markets ; Nationalism ; Populism ; Shock Therapy ; 1989 ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHQ History of other geographical groupings and regions ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history
    Language: English
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    Taylor & Francis | Routledge India
    Publication Date: 2024-01-30
    Description: The Last Mile explores the gaps and dichotomy between drafted policies and their implementation, and the last mile challenges which often make public services inaccessible to the poorest and most vulnerable sections of society. It provides an in-depth overview of the dynamics between communities, research and consultation and the implementation of policies for development. Rich in empirical data and case studies from different government programmes and reports, this book examines the implementation of government service programmes for poverty reduction, women’s empowerment, and income generation for the poor, among others, from a people’s perspective. It highlights the need for policies and institutions to align their methods to community needs. Offering guidelines for redesigning as well as solutions to counter challenges related to lack of trust and effective communication, human resource management, capacity development, redressal mechanisms, and facilitating the last mile connection, the author delineates effective ways for integrating new technologies in policy implementation. The book also addresses legacy issues in institutions and re-orienting policy for better governance, transparency, and building trust. Part of the Innovations, Practice and the Future of Public Policy in India series, this book, by a senior practitioner, will be an essential resource for students and researchers of development studies, sociology, public policy and governance, economics, and South Asian studies. This book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons (CC-BY-NC-ND) 4.0 license.
    Keywords: community development ; governance ; public policy ; social programmes ; socioeconomic development ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKS Social welfare & social services ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCM Development economics & emerging economies ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSF Rural communities ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTB Regional studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 28
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
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  • 29
    Publication Date: 2023-09-12
    Description: The Routledge Handbook of International Human Rights Law provides the definitive global survey of the discipline of international human rights law. Each chapter is written by a leading expert and provides a contemporary overview of a significant area within the field. As well as covering topics integral to the theory and practice of international human rights law the volume offers a broader perspective though examinations of the ways in which human rights law interacts with other legal regimes and other international institutions, and by addressing the current and future challenges facing human rights. Providing up-to-date and authoritative articles covering key aspects of international human rights law, this book work is an essential work of reference for scholars, practitioners and students alike. Chapter 35 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://www.routledgehandbooks.com/doi/10.4324/9780203481417.ch35
    Keywords: books by Nigel Rodley ; counter-terrorism and human rights ; economic, social and cultural rights ; human rights enforcement ; International criminal law and human rights ; International trade and human rights ; international human rights ; international human rights law ; investment and human rights ; Nigel Rodley ; non-State actors and human rights ; UN and human rights ; bic Book Industry Communication::L Law::LA Jurisprudence & general issues ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
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    ENS Éditions
    Publication Date: 2022-07-01
    Description: L’actualité politique en France se caractérise à la fois par une unification de la classe politique dans une perspective européenne et l’émergence de porte-parole au sein d’une société civile en mouvement. Cet ouvrage interroge, à la lumière de la Révolution française, le hiatus permanent entre l’action gouvernementale et le mouvement des sujets éphémères de la résistance civile. Ainsi, tout en valorisant les ressources propres des sentiments, des actions et des paroles des « sans », véritables « sans-culottes modernes », l’auteur s’appuie sur son itinéraire d’historien de la Révolution française pour décrire les potentialités novatrices du lien entre acteurs, spectateurs et législateurs qui se déploie actuellement au sein de la dynamique des mouvements sociaux.
    Keywords: Révolution française ; France ; mouvements sociaux ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: French
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    Amsterdam University Press
    Publication Date: 2024-03-29
    Description: A Continent Moving West? argues that the conceptualization of migration as a one-way or long-term process is becoming increasingly wide of the mark. Rather, east-west labor migration in Europe, in common perhaps with other flows in and from other parts of the world, is diverse, fluid, and influenced by the dynamics of local and sector-specific labor markets and migration-related political regulations. The papers in this book contribute to critical understanding of the east-west migration within the European Union after the 2004 enlargement, from the new to the old member states.
    Keywords: Sociology ; Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 33
    Publication Date: 2024-04-02
    Description: This book offers new historical, legal and literary explorations of a status held by uncountable formerly enslaved persons in the Roman Empire: Junian Latinity. It is the first book in any language to provide comprehensive multi-disciplinary study of this status. Divided in two parts, the book sets the scene with six chapters that discuss the legal innovations that created Junian Latinity, as well as the historical contexts in which the status was conceived and in which it developed – from the late republican period to the early medieval world. Four chapters in the second book part offer then new research on key Latin literary texts to provide fresh insights into the role of Junian Latinity in Roman imperial society. The book makes a strong case for the centrality of Junian Latinity in the Roman Empire and the importance of its modern study.
    Keywords: History ; Classical Studies ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 34
    Publication Date: 2024-03-23
    Description: This book is a historical study of the Tajiks in Central Asia from the ancient times to the post-Soviet period. For millennia, these descendants of the original Aryan settlers were part of many different empires set up by Greek, Arab, Turkic and Russian invaders, as well as their own, most notably during the Middle Ages. The emergence of the modern state of Tajikistan began after 1917 under Soviet rule, and culminated in the promulgation of independence from the moribund USSR in 1991. In the subsequent civil war that raged between 1992 and 1997, Tajikistan came close to becoming a failed state. The legacy of that internal conflict remains critical to understanding politics in Tajikistan a generation later. Exploring the patterns of ethnic identity and the exigencies of state formation, the book argues that despite a strong sense of belonging underpinned by shared history, mythology and cultural traits, the Tajiks have not succeeded in forming a consolidated nation. The politics of the Russian colonial administration, the national-territorial delimitation under Stalin, and the Soviet strategy of socio-economic modernisation contributed to the preservation and reification of sub-ethnic cleavages and regional identities. The book demonstrates the impact of region-based elite clans on Tajikistan’s political trajectory in the twilight years of the Soviet era, and identifies objective and subjective factors that led to the civil war. It concludes with a survey of the process of national reconciliation after 1997, and the formal and informal political actors, including Islamist groups, who compete for influence in Tajik society. “Tajikistan: A Political and Social History is the best source of information on this important country in the English language. Drs Nourzhanov and Bleuer present a comprehensive yet detailed account of the past and prospects of this emerging nation, and have filled one of the major gaps in Central Asian scholarship. This book must be read by those who wish to grasp the vagaries of Central Asia’s evolving political and cultural landscapes.” Reuel Hanks, Professor of Geography, Oklahoma State University, and Editor of the Journal of Central Asian Studies. “If Tajikistan is known outside its region, it is often for the civil war that gravely damaged it. This volume authoritatively provides the longer perspective to the unsettling events of the 1990s and skilfully explains them in terms of history, social structure, and sub-state identities. In addition to highlighting a wealth of local factors, it is insightful on the ways in which antagonists can be transformed into broader ethnic and regional blocs. Kirill Nourzhanov and Christian Bleuer are erudite guides to an understudied part of Central Asia, while astutely instructing us about larger patterns of state-society relations and their impact on the logic of conflict.” James Piscatori, Professor of International Relations, Durham University.
    Keywords: history ; tajikistan ; Central Asia ; Dushanbe ; Soviet Union ; Tajiks ; thema EDItEUR::1 Place qualifiers::1F Asia::1FC Central Asia::1FCD Tajikistan (Tadzhikistan) ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-02
    Description: Ages, Christopher, Contemporary, Everyday, Fletcher, Middle, Objects, Political, World
    Keywords: Ages, Christopher, Contemporary, Everyday, Fletcher, Middle, Objects, Political, World ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-02
    Description: This book provides a comparative and transnational examination of the complex and multifaceted experiences of anti-labour mobilisation, from the bitter social conflicts of the pre-war period, through the epochal tremors of war and revolution, and the violent spasms of the 1920s and 1930s. It retraces the formation of an extensive market for corporate policing, privately contracted security and yellow unionism, as well as processes of professionalisation in strikebreaking activities, labour espionage and surveillance. It reconstructs the diverse spectrum of right-wing patriotic leagues and vigilante corps which, in support or in competition with law enforcement agencies, sought to counter the dual dangers of industrial militancy and revolutionary situations. Although considerable research has been done on the rise of socialist parties and trade unions the repressive policies of their opponents have been generally left unexamined. This book fills this gap by reconstructing the methods and strategies used by state authorities and employers to counter outbreaks of labour militancy on a global scale. It adopts a long-term chronology that sheds light on the shocks and strains that marked industrial societies during their turbulent transition into mass politics from the bitter social conflicts of the pre-war period, through the epochal tremors of war and revolution, and the violent spasms of the 1920s and 1930s. Offering a new angle of vision to examine the violent transition to mass politics in industrial societies, this is of great interest to scholars of policing, unionism and striking in the modern era.
    Keywords: Armed Associations ; Austria-Hungary ; Czarism ; Dublin Lockout ; Geoff Eley ; Iberian Peninsula ; Industrial vigilantism ; Proto-Fascism ; Russian Empire ; The Dark Side of the Belle Époque ; Tsarism ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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    De Gruyter | De Gruyter Oldenbourg
    Publication Date: 2024-04-02
    Description: While the economic involvement of early modern Germany in slavery and the slave trade is increasingly receiving attention, the direct participation of Germans in human trafficking remains a blind spot in historiography. This edited volume focuses on practices of enslavement taking place within German territories in the early modern period as well as on the people of African, Asian, and Native American descent caught up in them.
    Keywords: Slavery ; Germany ; Atlantic history ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTR National liberation and independence ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTS Slavery and abolition of slavery
    Language: English
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  • 38
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Open Book Publishers
    Publication Date: 2024-03-29
    Description: In view of the challenges—many of which are political—that different European countries are currently facing, scholars who work on the 18th century have compiled this anthology which includes earlier recognitions of common values and past considerations of questions which often remain pertinent nowadays. During the Enlightenment, many men and women of letters envisaged the continent’s future in particular when stressing their hope that peace could be secured in Europe. The texts gathered here, and signed by major thinkers of the time (Rousseau, Montesquieu, Voltaire, Kant, Hume or Staël for instance), as well as by writers history has forgotten, present the reflections, with a couple of chronological extensions (from Sully to Victor Hugo) of authors from the long eighteenth century—the French Empire and the fall of Napoleon generated numerous upheavals—on Europe, its history, its diversity, but also on what the nations, which, in all their diversity, make up a geographical unit, have in common. They show the historical origins of the project of a European union, the desire to consolidate the continent’s ties to the Maghreb or to Turkey, the importance granted to commerce and the worries engendered by history’s convulsions, but also the hope vested in future generations."
    Description: "Face aux défis – entre autres politiques – auxquels sont confrontés différents pays européens, les chercheurs dix-huitiémistes ont souhaité revenir sur des expressions anciennes de valeurs partagées et les interrogations passées sur des questions qui restent souvent d’actualité. Au Siècle des Lumières, nombre d’hommes et de femmes de lettres ont envisagé l’avenir du continent en particulier pour entériner leur souhait de garantir la paix en Europe. Les textes, réunis dans cette anthologie, et signés des grands écrivains du temps (Rousseau, Montesquieu, Voltaire, Kant, Hume ou encore Staël), comme d’oubliés de l’histoire, présentent, avec quelques excursus chronologiques (de Sully à Hugo) les réflexions de penseurs d’un dix-huitième siècle aux bornes chronologiques étendues – l’émergence et la chute de l’Empire engendrent des bouleversements nombreux –, sur l’Europe, son histoire, sa diversité, mais aussi sur ce qu’ont en commun les nations qui composent, dans leur variété, un ensemble géographique. Ils mettent en évidence les origines historiques d’un projet d’union européenne, le souhait de consolider les liens du continent avec le Maghreb ou la Turquie, l’importance accordée au commerce et les inquiétudes suscitées par les sursauts de l’histoire, mais aussi l’espoir placé dans les générations futures. La Société française d’étude du XVIIIe siècle, l’Université d’Augsburg, l’Université d’Oxford ont généreusement contribué à la publication de ce volume.
    Keywords: siècle des lumières ; age of enlightenment ; peace ; hume ; anthologie ; european union ; rousseau ; voltaire ; paix ; kant ; union européenne ; europe ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: French
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    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Cet ouvrage interroge les formes que revêtent les mémoires, le rapport du politique au passé, le rapport de la société avec les experts et les chercheurs. Évoquer la question de la reconstruction d’une société après un épisode traumatique permet de retracer les filiations qui se font ou se défont au prisme de la mémoire et de l’histoire d’un pays. Le sujet principal est ici la guerre de Vendée, mais il aborde aussi d’autres conflits intraétatiques : Saint-Domingue devenue Haïti, l’Algérie, la Nouvelle-Calédonie du xvie siècle à nos jours. Ces contributions comparatives passent par l’archéologie, l’ethnologie, la littérature et l’histoire. Ce volume permet une meilleure compréhension de l’histoire et de la mémoire des guerres civiles telles qu’elles ont été pensées, écrites, reconstruites et transmises par les acteurs, les témoins, les contemporains, les historiens. Les douze textes, ponctués par les conclusions de Jean-Clément Martin, permettent de mieux entrer dans la fabrique des mémoires des guerres civiles d’hier et d’aujourd’hui.
    Keywords: guerre civile ; amnistie ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    De Gruyter | De Gruyter
    Publication Date: 2024-04-03
    Description: Society begins at the local level. This interdisciplinary volume analyzes different kinds of local self-organization against the backdrop of the rather limited states of Antiquity and the Global South of the present. By collaborating across different periods of time the contributors get a better grasp of the mechanisms by which local governance succeeds, and advance the theoretical debate on state and society.
    Keywords: civil society ; collective identity ; global history ; limited statehood ; thema EDItEUR::D Biography, Literature and Literary studies::DB Ancient, classical and medieval texts ; thema EDItEUR::N History and Archaeology::NH History::NHA History: theory and methods ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology::NK Archaeology::NKD Archaeology by period / region ; thema EDItEUR::1 Place qualifiers::1Q Other geographical groupings: Oceans and seas, historical, political etc::1QB Historical states, empires, territories and regions::1QBA Ancient World ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPR Regional, state and other local government
    Language: English
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    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Presses universitaires de Strasbourg
    Publication Date: 2024-04-02
    Description: Dans sa Démonolâtrie (1595), le procureur général de Lorraine, Nicolas Remy, estime que « Les sorciers appartiennent la plupart du temps au monde des bourgs et des campagnes. ». Cependant, les vauderies survenues à Lyon et Arras au XVe siècle comme les cas de possession du XVIIe siècle sont autant de témoignages de la présence de la sorcellerie dans les villes européennes. Les études de cas et les essais comparatifs réunis dans ce volume montrent qu'en dépit de la diversité des sociétés urbaines, la sorcellerie apparaît comme un révélateur des enjeux de pouvoir qui traversent les villes modernes.Dans sa postface, Carlo Ginzburg insiste sur la portée d'une approche comparatiste, toujours attentive aux écarts à la norme, et souligne l'importance d’aborder les procès de sorcellerie comme une manifestation particulière des tensions sociales et culturelles.
    Keywords: époque moderne ; Europe ; histoire urbaine ; sorcellerie ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    Éditions de la Sorbonne
    Publication Date: 2024-04-02
    Description: Les deux parties de cet ouvrage présentent et analysent les professions de foi des députés de Loire-Atlantique sous la IIIe République. Ces deux parties sont à bien des égards originales : • La première, par son exploration scientifique d’un matériau généralement négligé, au motif qu’il n’aurait d’autre intérêt que de restituer la rhétorique des candidats à la députation ; • La seconde, par la reproduction des textes analysés — les proclamations électorales des députés du pays « nantais » — donnant ainsi au lecteur l’ac­cès direct aux matériaux utilisés. L’ensemble de la contribution devrait retenir l’intérêt tant des chercheurs que des lecteurs sensibilisés à une histoire politique tout à la fois concrète et néan­moins contextualisée. Par ailleurs, cet ouvrage complète, prolonge Monarchie et Modernité publié chez le même éditeur.
    Keywords: langage ; gouvernement ; sociologie politique ; parlementaire ; homme politique ; document électoral ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    Liverpool University Press
    Publication Date: 2024-03-26
    Description: An Open Access edition of this work is available on Modern Languages Open (https://www.modernlanguagesopen.org/). On 12 March 2018, Mauritius celebrated fifty years as an independent nation amidst much fanfare. Yet behind the nation's official image of multicultural 'unity in diversity' lurk deep socio-economic inequalities and inter-ethnic tensions that are insistently critiqued in its literature. Against this backdrop, this book analyses how the idea of belonging - a sense of attachment to, and identification with, a place or people - is problematised in a range of contemporary francophone Mauritian novels. The island-nation's complex history and the multi-ethnic composition of its modern-day population mean that belonging is a central but fraught issue in both reality and fiction. Waters explores how diverse forms of affirmative, affective belonging intersect with, and are frequently inhibited by, exclusionary 'politics of belonging' at communal, national or international levels. Using an eclectic theoretical approach to the central concept of belonging, Waters offers in-depth textual analyses of novels by leading Mauritian writers Nathacha Appanah, Ananda Devi, Shenaz Patel, Bertrand de Robillard, Amal Sewtohul and Carl de Souza. Despite their thematic and formal diversity, these novels are shown to be characterised by a common rejection of dominant discourses of ethnic, diasporic affiliation and by a common commitment to the ongoing, future-orientated project of Mauritian nationhood. As such, this book offers an original insight into the dynamics of belonging and exclusion in diverse, multi-ethnic societies.
    Keywords: Language & Literature ; European Studies ; African Studies ; History ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
    Language: English
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    Publication Date: 2024-04-02
    Description: This volume provides an ambitious synopsis of the complex, colourful world of textiles in ancient Mediterranean iconography. A wealth of information on ancient textiles is available from depictions such as sculpture, vase painting, figurines, reliefs and mosaics. Commonly represented in clothing, textiles are also present in furnishings and through the processes of textile production. The challenge for anyone analysing ancient iconography is determining how we interpret what we see. As preserved textiles rarely survive in comparable forms, we must consider the extent to which representations of textiles reflect reality, and critically evaluate the sources. Images are not simple replicas or photographs of reality. Instead, iconography draws on select elements from the surrounding world that were recognisable to the ancient audience, and reveal the perceptions, ideologies, and ideas of the society in which they were produced. Through examining the durable evidence, this anthology reveals the ephemeral world of textiles and their integral role in the daily life, cult and economy of the ancient Mediterranean.
    Keywords: History ; Ancient ; Rome ; History ; Ancient ; Design ; Textile & Costume ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::A The Arts::AK Design, Industrial and commercial arts, illustration::AKT Fashion and textile design
    Language: English
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  • 49
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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    CNRS Éditions
    Publication Date: 2023-09-11
    Description: While several atlases of Ancient Egypt exist, no atlas of contemporary Egypt has yet been published. Thus, this work fills a void and offers the general public an illustrated panorama of Egypt at the beginning of the 21st century. Through the contributions of some fifty researchers, it presents in an accessible form the key facts and challenges that concern present-day Egypt in the realms of politics, economics, demographics, the environment, society and culture, and geopolitics. To this end, the Atlas relies on a wide array of previously unpublished sources, most especially maps, which help to unlock and interpret the results of the official Egyptian census of 2017, providing an up-to-date view of the country and a better understanding of Egypt today.
    Keywords: Egypt ; geopolitics ; demography ; geohistory ; Greater Cairo ; Egyptian provinces ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography
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    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Terre de mélanges culturels et de politiques coloniales, la Tunisie a attiré de l’Europe des courants d’immigrations aussi bien que des visées impérialistes. La trajectoire des Juifs italiens, dits Livournais, s’inscrit au carrefour de ces axes. Une communauté enracinée en Tunisie depuis le xviie siècle, mais toujours assimilée au monde européen. Une population cosmopolite, mais jalousement attachée à Livourne et à l’Italie. Une double minorité, à l’égard tant de la nombreuse population juive locale que des cent mille émigrés italiens vivant en Tunisie au début du xxe siècle, mais toujours caractérisée par une forte identité collective. Pendant l’entre-deux-guerres, la place sociale de cette communauté fut remise en cause par une série de phénomènes convergents : l’essor du nationalisme tunisien, les tensions diplomatiques italo-françaises, et surtout par la montée au pouvoir du régime fasciste, résolu à encadrer les communautés d’émigration dans sa politique impériale. Sur la base de fonds d’archives et de témoignages inédits, ce travail reconstruit le parcours des Juifs italiens de Tunisie face aux stratégies de fascisation de Rome, en interrogeant les croisements identitaires dans les contextes d’émigration, la question de l’adhésion de masse au totalitarisme et le poids des médiateurs au sein des sociétés coloniales.
    Keywords: juifs ; judaïsme ; italien ; fascisme ; émigration et immigration ; colonialisme ; diaspora ; totalitarisme ; antisémitisme ; mémoire ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHH African history
    Language: French
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: This book investigates the ways in which soft power is used by African countries to help drive global influence. Selecting four of the countries most associated with soft power across the continent, this book delves into the currencies of soft power across the region: from South Africa’s progressive constitution and expanding multinational corporations, to Nigeria’s Nollywood film industry and Technical Aid Corps (TAC) scheme, Kenya’s sport diplomacy, fashion and tourism industries, and finally Egypt’s Pan-Arabism and its reputation as the cradle of civilisation. The book asks how soft power is wielded by these countries and what constraints and contradictions they encounter. Understandings of soft power have typically been driven by Western scholars, but throughout this book, Oluwaseun Tella aims to Africanise our understanding of soft power, drawing on prominent African philosophies, including Nigeria’s Omolúwàbí, South Africa’s Ubuntu, Kenya’s Harambee, and Egypt’s Pharaonism. This book will be of interest to researchers from across political science, international relations, cultural studies, foreign policy and African Studies.
    Keywords: African Studies ; cultural studies ; foreign policy ; international relations ; political science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTB Regional studies
    Language: English
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    Ubiquity Press
    Publication Date: 2024-03-29
    Description: While disarmament, demobilization and reintegration (DDR) and security sector reform (SSR) have become integral statebuilding tools in post-conflict states, the existing empirical literature examining their relationship has focused on supply-side considerations related to the programming of both processes. In practice, though, DDR and SSR are implemented in the wider context of war-to-peace transitions where the state is attempting to establish a monopoly over the use of force and legitimize itself in the eyes of domestic and international communities. This paper therefore assumes that to identify opportunities and constraints for establishing closer practical linkages between DDR and SSR it is important to take the local politics into consideration. It examines two past externally driven peacebuilding interventions in West Africa, namely Liberia and Sierra Leone, featuring cases in which the central state had essentially fragmented or collapsed. Through this comparative analysis, the paper aims to provide a stepping-stone for future studies examining demand-side considerations of DDR and SSR in post-conflict contexts.
    Keywords: security sector reform ; good governance ; peacebuilding ; transition ; DDR ; demobilization ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JW Warfare & defence ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence
    Language: English
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    Publication Date: 2024-03-23
    Description: This book depicts the long rich life and wide ranging work of Count Athanasius Raczyński (1788–1874). By exploring his complex personality, his processes of thought and his accomplishments, it reveals a man at once a wealthy aristocrat, a Pole in the Prussian diplomatic service, an active participant in and perceptive observer and critical commentator on political life, a connoisseur and art collector of European renown, and the author of ground breaking studies on German and Portuguese art – in short a distinguished and fascinating nineteenth century figure.
    Keywords: 19th-century Berlin ; aristocracy ; art collecting ; art historiography ; German painting ; History of collections ; history of diplomacy ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGA History of art ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day
    Language: English
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  • 55
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 56
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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    Maven Publishers
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
    Language: English
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    Johns Hopkins University Press
    Publication Date: 2024-04-02
    Description: Originally published in 1974. Focusing on a set of Jewish communities, Robert Chazan tells how, by the eleventh century, French Jews had created for themselves a role as local merchants and moneylenders in adapting to the political, economic, and social limits imposed on them. French society, striving to become more powerful and civilized, was willing to extend aid and protection to the Jews in return for general stimulation of trade and urban life and for the immediate profit realized from taxation. While the authorities were relatively successful in protecting the Jews from others, there was no power to impose itself between the Jews and their protectors. The political and social well-being of the Jews was, therefore, dependent on the will of the governing authorities who taxed their holdings and regulated their activities. During the twelfth and thirteenth centuries, the position of the Jews was constantly under attack by reform elements in the church concerned with Jewish moneylending and blasphemous materials in Jewish books; these reformers were eventually devoted to a serious missionizing effort within the Jewish community. The Jews' situation was further complicated by deep popular animosity, expressing itself in a damaging set of slanders and occasionally in physical violence. Despite the impressive achievements of the Jews in medieval northern France, by the thirteenth century their community was increasingly constricted; and in 1306, they were expelled from royal France by Philip IV. Overcoming the handicap of a lack of copious source material, Chazan analyzes the Jews' political status, their relations with key elements of Christian society, their demographic development, their economic outlets, their internal organization, and their attitudes toward the Christian environment. As it highlights aspects of French society from an unusual perspective, Medieval Jewry in Northern France should be of special interest to the historian of medieval France as well as to the student of Jewish history. This story is also significant for all who are fascinated by the capacity of human groups to respond and adapt creatively to a hostile and limiting environment.
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Central European University Press
    Publication Date: 2024-04-04
    Description: This social, cultural, and political history of Slavic Muslim women of the Yugoslav region in the first decades of the post-Ottoman era is the first to provide a comprehensive overview of the issues confronting these women. It is based on a study of voluntary associations (philanthropic, cultural, Islamic-traditionalist, and feminist) of the period. It is broadly held that Muslim women were silent and relegated to a purely private space until 1945, when the communist state “unveiled” and “liberated” them from the top down.  After systematic archival research in Bosnia, Croatia, Serbia, and Austria, Fabio Giomi challenges this view by showing:  How different sectors of the Yugoslav elite through association publications, imagined the role of Muslim women in post-Ottoman times, and how Muslim women took part in the construction or the contestation of these narratives.  How associa­tions employed different means in order to forge a generation of “New Muslim Women” able to cope with the post-Ottoman political and social circumstances.  And how Muslim women used the tools provided by the associations in order to pursue their own projects, aims and agendas.  The insights are relevant for today’s challenges facing Muslim women in Europe. The text is illustrated with exceptional photographs.
    Keywords: History ; Women ; History ; Europe ; Eastern ; Social Science ; Gender Studies ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Helsinki University Press | Helsinki University Press
    Publication Date: 2024-04-02
    Description: Arendt, Eichmann and the Politics of the Past offers a critical analysis of the original American debate over Hannah Arendt’s report of the trial of Adolf Eichmann. First published in 2008, Tuija Parvikko’s book discusses both the campaign against Arendt organised by American Zionist organisations and the controversy Arendt’s report caused within American Jewish intellectual circles. Parvikko’s analysis carefully draws from the historical background of the report, discussing Arendt’s early studies of Zionism and her critique of the Jewish state. The volume also gives an account of Eichmann’s capture in Argentina and the reception of the report among legal scholars and the world press.;This edition includes a new prologue in which Parvikko reflects on her own account in connection to recent academic discussions on the controversy. The author’s analysis also covers contributions that have attempted to follow Arendt’s notion of thinking without banisters. With them, Parvikko engages in debate about going beyond Arendt’s theoretical reflections on cohabitation, sharing the world, and discussing the new political evils of the present world without pregiven norms and patterns of thought.
    Keywords: political judgement ; the politics of the past ; the Eichmann trial ; victimology ; political trial ; Hannah Arendt ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::Y Children’s, Teenage and Educational::YF Children’s / Teenage fiction and true stories::YFT Children’s / Teenage fiction: Historical fiction ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
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  • 62
    Publication Date: 2024-03-12
    Description: This book explores the ethics of national security intelligence institutions operating in contemporary liberal democracies. Intelligence collection by agencies such as the CIA, MI6, and Mossad involves practices that are apparently inconsistent with the principles of ordinary morality – practices such as lying, spying, manipulation, and covert action. However, in the defence of national security, such practices may not only be morally permissible, but may also under some circumstances be morally obligatory. One approach to the ethics of national security intelligence activity has been to draw from the just war tradition (so-called ‘just intelligence theory’). This book identifies significant limitations of this approach and offers a new, institutionally based, teleological normative framework. In doing so, it revises some familiar principles designed for application to kinetic wars, such as necessity and proportionality, and invokes some additional ones, such as reciprocity and trust. It goes on to explore the applications of this framework and a revised set of principles for national security intelligence institutions and practices in contemporary and emerging political and technological settings. This book will be of much interest to students of intelligence studies, ethics, security studies and International Relations.
    Keywords: ethical institutions;best practice;intelligence services;new technologies;just war model ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JW Warfare & defence ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTJ Peace studies & conflict resolution ; bic Book Industry Communication::H Humanities::HP Philosophy::HPQ Ethics & moral philosophy ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMR Cognition & cognitive psychology::JMRN Intelligence & reasoning
    Language: English
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    Historic England | Historic England
    Publication Date: 2024-04-04
    Description: This volume offers a new and up-to-date synthesis of Lincoln's long history as a major city and regional capital, from prehistory to 1945. The 'City by the Pool' was a major religious centre long before the Roman invasion and from bronze-age shamans to early Baptists people have always been attracted here for spiritual as well as mundane purposes. The authors argue for the presence of a major ritual causeway of the late Bronze and Iron Age and outline the extent to which ritual monuments also contributed to the character of Roman Lincoln. This book is based on more than a hundred publicly-funded excavations and building surveys undertaken between 1945 and 2000. It surveys all aspects of city life, from housing and fortifications to the water supply and rubbish disposal. It includes a CD Rom with a Geographic Information System (GIS) and a relational data-base known as LARA (the Lincoln Archaeological Research Assessment).
    Keywords: Social Science ; Archaeology ; History ; Europe ; Great Britain ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    Publication Date: 2024-04-14
    Description: The authors comprehensively analyze all the available information regarding the ritual practices of Slavic pre-Christian religion that can be found in written medieval texts. After investigating every kind of reference to such practices, they offer a reconstruction of Slavic pre-Christian religion on the basis of these medieval testimonies. In doing so, they overcome the challenges presented by the fact that all of these sources are indirect, since the Slavs did not acquire literacy until they became Christians. Thus the writers of these texts mostly professed a monotheistic religion, being Christians and in some cases Muslims. The picture that they offer is biased and determined by their own faith. The present analysis innovatively combines testimonies from every Slavic area (Eastern, Western, and Southern), showing their mutual correspondences and emphasizing the relationship between the Slavic pre-Christian religion and its Indo-European roots.
    Keywords: Slavic peoples;Baltic peoples;folklore;pagan religions;early Middle Ages ; thema EDItEUR::V Health, Relationships and Personal development::VX Mind, body, spirit::VXW Mysticism, magic and occult interests::VXWS Shamanism, paganism and Druidry ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBG Popular beliefs and controversial knowledge::JBGB Folklore studies / Study of myth (mythology) ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFF Historical and comparative linguistics
    Language: English
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    Éditions de la Maison des sciences de l’homme
    Publication Date: 2024-03-23
    Description: Organized through the initiative of the Ministry of Culture and Communication, the symposium “Lascaux and Preservation Issues in Subterranean Environments” was held in Paris on February 26 and 27, 2009 under the chairmanship of Jean Clottes. It brought together nearly three hundred participants from seventeen countries with the goal of confronting research and interventions conducted in Lascaux Cave since 2001 with the experiences gained in other countries in the domain of preservation in subterranean environments. Twelve presentations addressed questions related to disciplines such as hydrogeology, climatology and microbiology in relation to the protection and valorization of decorated caves. The talks were followed by debates allowing the experts and all other participants to freely express themselves. This volume, which constitutes the proceedings of this symposium, is composed of the studies presented during the sessions and full transcriptions of the debates. It provides both a synthesis of the conservation activities realized at Lascaux between 2001 and 2009 and the state of research and the conditions of the cave as of 2009.
    Keywords: peinture murale ; grotte de Lascaux ; conservation préventive ; microbiologie ; milieu souterrain ; thema EDItEUR::A The Arts::AB The arts: general topics::ABC Conservation, restoration and care of artworks ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NK Archaeology
    Language: French
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  • 66
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
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    University of New Orleans Press
    Publication Date: 2024-04-02
    Description: This volume celebrates the study of Austria in the twentieth century by historians, political scientists and social scientists produced in the previous twenty-four volumes of Contemporary Austrian Studies. One contributor from each of the previous volumes has been asked to update the state of scholarship in the field addressed in the respective volume. The title Austrian Studies Today, then, attempts to reflect the state of the art of historical and social science related studies of Austria over the past century, without claiming to be comprehensive. The volume thus covers many important themes of Austrian contemporary history and politics since the collapse of the Habsburg Monarchy in 1918―from World War I and its legacies, to the rise of authoritarian regimes in the 1930s and 1940s, to the reconstruction of republican Austria after World War II, the years of Grand Coalition governments and the Kreisky era, all the way to Austria joining the European Union in 1995 and its impact on Austria's international status and domestic politics.
    Keywords: History ; Political Science ; European Studies ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
    Language: English
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    Taylor & Francis | The Hispanic-Anglosphere from the Eighteenth to the Twentieth Century | Routledge
    Publication Date: 2024-04-02
    Description: The Hispanic and Anglo worlds are often portrayed as the Cain and Abel of Western culture, antagonistic and alien to each other. This book challenges such view with a new critical conceptual framework – the ‘Hispanic-Anglosphere’ – to open a window into the often surprising interactions of individuals, transnational networks and global communities that, it argues, made of the British Isles (England, Ireland, Scotland, Wales, the Channel Islands and the Isle of Man) a crucial hub for the global Hispanic world, a launching-pad and a bridge between Spanish Europe, Africa, America and Asia in the late eighteenth to the early twentieth centuries. Perhaps not unlike today, that was a time marked by social uncertainty, pandemics, the dislocation of global polities and the rise of radicalisms. The volume offers insights on many themes including trade, the arts, education, language, politics, the press, religion, biodiversity, philanthropy, anti-slavery and imperialism. Established academics and rising stars from different continents and disciplines combined original, primary research with a wide range of secondary sources to produce a rich collection of ten case-studies, 25 biographies and seven samples of interpreted material culture, all presented in an accessible style appealing to scholars, students and the general reader alike.
    Keywords: Anti-slavery, Biodiversity, Hispanic-anglosphere, Philanthropy ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    Taylor & Francis | Routledge
    Publication Date: 2024-01-30
    Description: Climate change is perhaps the greatest threat to humanity today and plays out as a cruel engine of myriad forms of injustice, violence and destruction. The effects of climate change from human-made emissions of greenhouse gases are devastating and accelerating; yet are uncertain and uneven both in terms of geography and socio-economic impacts. Emerging from the dynamics of capitalism since the industrial revolution — as well as industrialisation under state-led socialism — the consequences of climate change are especially profound for the countryside and its inhabitants. The book interrogates the narratives and strategies that frame climate change and examines the institutionalised responses in agrarian settings, highlighting what exclusions and inclusions result. It explores how different people — in relation to class and other co-constituted axes of social difference such as gender, race, ethnicity, age and occupation — are affected by climate change, as well as the climate adaptation and mitigation responses being implemented in rural areas. The book in turn explores how climate change – and the responses to it - affect processes of social differentiation, trajectories of accumulation and in turn agrarian politics. Finally, the book examines what strategies are required to confront climate change, and the underlying political-economic dynamics that cause it, reflecting on what this means for agrarian struggles across the world. The 26 chapters in this volume explore how the relationship between capitalism and climate change plays out in the rural world and, in particular, the way agrarian struggles connect with the huge challenge of climate change. Through a huge variety of case studies alongside more conceptual chapters, the book makes the often-missing connection between climate change and critical agrarian studies. The book argues that making the connection between climate and agrarian justice is crucial. The chapters in this book were originally published in The Journal of Peasant Studies.
    Keywords: Agrarian justice;Climate change;Climate Smart Agriculture;Critical Agrarian Studies;Environmental Politics ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RND Environmental policy & protocols
    Language: English
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: Steep socioeconomic hierarchy in post-industrial Western society threatens public health because of the physiological consequences of material and psychosocial insecurities and deprivations. Following on from their previous books, the authors continue their exploration of the geography of early mortality from age-related chronic conditions, of risk behaviors and their health outcomes, and of infant and child mortality, all due to rigid hierarchy. They divide the 50 states into those that gave their electoral college votes to Trump and those that gave theirs to Clinton in the 2016 presidential election and compare the two sets for socioeconomic and public health profiles. They deliberately apply only simple standard statistical methods in the public health analyses: t-test, Mann-Whitney test, bivariate regression, and backward stepwise multivariate regression. The book assumes familiarity with basic statistics. The authors argue that the unequal power relations that result in eroding public health in the nation and, in particular, in the Trump-voting states, largely cascade from the collapse of American industry, and they analyze the Cold War roots of that collapse. In two largely independent chapters on economics, they explore both the suppression of countervailing forces, such as organized labor, and the diversion of technical resources to the military as essential foundations to the population-level suffering that expressed itself in the 2016 presidential election. This interdisciplinary book has several primary audiences: creators of public policies, such as legislators and governmental staff, public health professionals and social epidemiologists, economists, labor union professionals, civil rights advocates, political scientists, historians, and students of these disciplines from public health through the social sciences. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.
    Keywords: Business and Management;Development economics and emerging economies;Economics;International economics;Political economy;Medicolegal issues;Public health and preventive medicine;Politics and government ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCM Development economics & emerging economies ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCL International economics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBQ Medicolegal issues ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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    Publications de l’École française de Rome
    Publication Date: 2024-04-02
    Description: Ce quatrième et dernier volume du programme L’héritage byzantin en Italie (VIIIe-XIIe siècle), qui cherchait à analyser et à comparer l’évolution des régions autrefois soumises à l’autorité byzantine, de la Vénétie à la Sicile et à la Sardaigne en passant par Ravenne, Rome, Naples, le Salento et la Calabre, a pour thème des realia. On s’est intéressé aux originalités touchant à l’occupation du sol, aux formes de la grande propriété, aux contrats agraires et aux platee (listes de dépendants), enfin à la production et au commerce. La Sicile (sous les dominations byzantine et islamique) et la Sardaigne judicale (souvent négligée) sont bien représentées, à côté des diverses régions continentales ayant dépendu de l’Exarchat. Si, comme on s’y attendait, les évolutions sont dissemblables, les conclusions de Chris Wickham montrent la force de la tradition byzantine à propos de la grande propriété et du commerce ; l’héritage byzantin n’est pas uniforme, mais, même dans ces domaines éloignés de l’idéologie, il a laissé des traces durables.
    Keywords: Italie ; Byzance ; économie agraire ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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    Publication Date: 2022-04-28
    Description: Papua New Guinea has a complex ‘law and order’ problem and an entrenched epidemic of HIV. This book explores their interaction. It also probes their joint challenges and opportunities—most fundamentally for civic security, a condition that could offersome immunity to both. This book is a valuable and timely contribution to a limited but growing body of scholarship in the social and structural contexts of HIV epidemiology in Papua New Guinea. The volume offers a unique collection of interdisciplinary insights on the connections between law and order and the HIV epidemic and is presented in a manner accessible to a wide audience, scholars and lay people alike… Significantly, this is the first volume to critically examine the complex and inexorable links between HIV, gender, violence, and security within a theoretical framework thv at illuminates the challenges of the epidemic for PNG’s future cohesion and stability as a young nation…The importance of this courageous book cannot be overstated. While it communicates an urgent and potent message about the need for immediate action … it offers insightful reflections on the processes and possibilities of social transformation that undoubtedly will have enduring scholarly and practical value. Dr Katherine Lepani, Social Foundations of Medicine, The Australian National University.
    Keywords: politics and goverment ; law enforcement ; social conditions ; papua new guinea ; aids ; crime ; hiv infections ; Condom ; HIV/AIDS ; Portable Network Graphics ; Prostitution ; Rape ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::L Law::LA Jurisprudence & general issues::LAQ Law & society
    Language: English
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    Amsterdam University Press
    Publication Date: 2024-04-02
    Description: Scholarship on early medieval England has seen an exponential increase in scholarly work by and about women over the past twenty years, but the field has remained peculiarly resistant to the transformative potential of feminist critique. Since 2016, Medieval Studies has been rocked by conversations about the state of the field, shifting from #MeToo to #WhiteFeminism to the purposeful rethinking of the label “Anglo-Saxonist.” This volume takes a step toward decentering the traditional scholarly conversation with thirteen new essays by American, Canadian, European, and UK professors, along with independent scholars and early career researchers from a range of disciplinary perspectives. Topics range from virginity, women’s literacy, and medical discourse to affect, medievalism, and masculinity. The theoretical and political commitments of this volume comprise one strand of a multivalent effort to rethink the parameters of the discipline and to create a scholarly community that is innovative, inclusive, and diverse.
    Keywords: Medieval, Old English, women, gender ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls::JBSF11 Feminism and feminist theory
    Language: English
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    Éditions Universitaires d’Avignon
    Publication Date: 2022-07-01
    Description: De plus en plus d’institutions culturelles renouvellent leurs dispositifs d’aide à la visite en intégrant les plus récentes technologies et en sollicitant la participation des publics. L’intérêt de cet ouvrage interdisciplinaire est de mobiliser des études de cas et des analyses complémentaires afin de mettre en exergue les enjeux muséographiques, politiques et économiques de ces mises en scène patrimoniales, du Palais des Papes d’Avignon au secteur Unesco de Lyon notamment. Dans une perspective proche de celle des cultural studies, les textes relient les questions épistémologiques de chercheurs en sciences humaines et sociales avec les pratiques médiatiques des professionnels et publics du patrimoine.
    Keywords: médiation numérique ; muséologie ; patrimoine culturel ; scénographie d'exposition ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: French
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    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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    Manchester University Press
    Publication Date: 2024-03-29
    Description: Deportation limbo traces the efforts of two Nordic welfare states, Denmark and Sweden, to address the so-called implementation gap in deportation enforcement. It offers an original, empirically grounded account of how often-futile, injurious policy measures devoted to pressuring non-deported people to leave are implemented and contested in practice. In doing so, it presents a critique of the widespread, normalised use of detention, encampment, and destitution, which routinely fail to enhance deportations while exposing deportable people to conditions that cause their premature death. The book takes the ‘deportation limbo’ as a starting point for exploring the violent nature of borders, the racial boundaries of welfare states, and the limits of state control over cross-border mobility. Building on unprecedented access to detention and deportation camps and migration offices in both countries, it presents ethnographic material capturing frontline officials’ tension-ridden efforts to regulate non-deported people using forced deportation, incarceration, encampment, and destitution. Using a continuum of state violence as the analytical lens, the book offers a uniquely comprehensive account of how the borders of Nordic welfare states are drawn through practices that subject racialised ‘others’ to expulsion, incarceration, and destitution. The book is the first to systematically document the renewed deportation turn in Denmark and Sweden, and to critically examine its implications: for the people targeted by intensified deportation measures, and for the individual officials, institutions, and societies enforcing them. It offers an important, critical contribution to current debates on the violence of deportation regimes, the politico-bureaucratic structures and practices that sustain them, and their human costs.
    Keywords: deportation ; political ethnography ; Denmark ; Sweden ; detention ; violence ; welfare state ; humanitarianism ; critical border studies ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFN Migration, immigration & emigration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFH Migration, immigration and emigration ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PB Relating to peoples: ethnic groups, indigenous peoples, cultures and other groupings of people::5PBC Relating to migrant groups / diaspora communities or peoples ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2021-02-10
    Description: This open access book seeks to understand how politics is being made in a pluralistic sense, and explores how these political struggles are challenging and transforming gender, sexuality, and colonial norms. As researchers located in Sweden, a nation often cited as one of the most gender-equal and LGBTQ-tolerant nations, the contributions investigate political processes, decolonial struggles, and events beyond, nearby, and in between organizations, states, and national territories. The collection represents a variety of disciplines, and different theoretical conceptualizations of politics, feminist theory, and postcolonial and queer studies. Students and researchers with an interest of queer studies, gender studies, critical whiteness studies, and civil society studies will find this book an invaluable resource.
    Keywords: Gender and Sexuality ; Queer Theory ; Politics and Gender ; Culture and Gender ; Gender Studies ; Queer Studies ; Gender and Culture ; communities of belonging ; homonationalism ; femonationalism ; decoloniality ; intersectionality ; transnationalism ; Open Access ; Gender studies, gender groups ; Gay & Lesbian studies ; Politics & government ; Cultural studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies
    Language: English
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    Taylor & Francis | Routledge
    Publication Date: 2024-03-29
    Description: This introductory chapter sets out with a review of the existing literature on differentiation in the European Union (EU); it explains the related concepts and includes a cursory glossary of them at the end. In a nutshell, we conceive of differentiation as an umbrella term covering a wide range of both integrationist and – albeit to a much lesser extent – disintegrationist techniques and processes such as multi-speed Europe, variable geometry, and à la carte Europe. While differentiation has not been a constituent feature in the early stages of the European project starting after World War II, it became ever more central since the 1970s and, in particular, in the aftermath of the Treaty of Maastricht when the EU was characterized as a system of differentiated integration rather than integration only. In light of ‘Brexit’, i.e. the United Kingdom’s withdrawing from the EU, however, differentiation also accounts for processes of disintegration. Most importantly, differentiation may ultimately also prove to be an important element towards sustaining – if not self-reinforcing – integration. Finally, this chapter also provides overview of contemporary studies of differentiation in the EU and provides an overview of the contents and contributions of this Handbook.
    Keywords: differentiation; European Union; differentiated integration; disintegration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
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    Presses universitaires de Rennes
    Publication Date: 2024-04-02
    Description: Depuis plus d’un siècle la notion de « nuisible » fait l’objet d’une contestation de plus en plus vive. Pourtant elle connaît une singulière persistance sociale en tant que concept opérationnel qui donne aux hommes une certaine légitimité pour gérer, et souvent détruire, certaines espèces. À l’heure où la France vient d’adopter la loi sur la reconquête de la biodiversité, la question des « nuisibles » reprend une singulière acuité avec la multiplication d’espèces exotiques envahissantes et les vives controverses qui demeurent autour du loup, du renard mais aussi de l’utilisation des insecticides et des herbicides pour se défaire de « gêneurs ». Si la notion de « nuisible » demeure centrale dans la gestion du sauvage par nos sociétés, elle s’avère très variable selon l’époque, l’espèce, le territoire ou le groupe social considéré. Pour dresser un état de la recherche, historiciser cette notion et éclairer les enjeux actuels, il convient de croiser les regards afin de caractériser les différentes conceptions de la notion de « nuisible » qui coexistent actuellement et d’en retracer les origines, tout en s’ouvrant aux acteurs du présent. Ainsi cet ouvrage entend contribuer à explorer les interactions entre les sociétés et la nature, et permettre de mieux saisir leurs coévolutions.
    Keywords: environnement ; histoire longue durée ; sciences humaines et sociales ; biodiversité ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RND Environmental policy and protocols
    Language: French
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    Publications de l’École française de Rome
    Publication Date: 2024-03-29
    Description: Cet ouvrage collectif naît d’abord d’un contexte. À une époque où les crises s’enchaînent au point de paraître permanentes, les législations d’urgence et les mesures dérogatoires connaissent une expansion telle que l’exception semble devenir la règle. Pourtant, le concept même d’état d’exception ne va pas de soi et alimente, dans le champ académique, de nombreux débats. Ne masque-t-il pas, derrière le sentiment partagé de quitter un monde politique et constitutionnel stabilisé, des situations juridiques très différentes ? Ce faisant, ne nous rend-il pas, paradoxalement, impuissants à penser le monde qui vient ? Les textes rassemblés ici proposent d’élargir ces réflexions en les réinscrivant dans une perspective historique longue. Ils présentent un vaste répertoire des formes historiques de « l’exceptionnalité », depuis l’institution romaine de la dictature jusqu’à l’état d’urgence contemporain, en tenant compte des normes et des pratiques juridico-politiques, mais aussi des concepts qui leur ont été associés. Au fil d’un dialogue entre histoire et philosophie, l’ouvrage s’ouvre à d’autres disciplines et aux réflexions transversales qui ont accompagné ces concepts. Il interroge la manière dont des termes « dictature » ou « état d’exception » circulent et se modifient, en laissant émerger des questions récurrentes, notamment autour du rapport du droit et du politique à l’histoire et au temps.
    Keywords: pouvoirs exceptionnels ; autoritarisme ; philosophie politique ; mesures d’exception ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: French
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    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Language: English
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  • 87
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    University of Illinois Press
    Publication Date: 2024-04-02
    Description: How music embodies and contributes to historical and contemporary nationalism What does music in Portugal and Spain reveal about the relationship between national and regional identity building? How do various actors use music to advance nationalism? How have state and international heritage regimes contributed to nationalist and regionalist projects? In this collection, contributors explore these and other essential questions from a range of interdisciplinary vantage points. The essays pay particular attention to the role played by the state in deciding what music represents Portuguese or Spanish identity. Case studies examine many aspects of the issue, including local recording networks, so-called national style in popular music, and music’s role in both political protest and heritage regimes. Topics include the ways the Salazar and Franco regimes adapted music to align with their ideological agendas; the twenty-first-century impact of UNESCO’s Intangible Cultural Heritage program on some of Portugal and Spain's expressive practices; and the tensions that arise between institutions and community in creating and recreating meanings and identity around music. Contributors: Ricardo Andrade, Vera Marques Alves, Salwa El-Shawan Castelo-Branco, Cristina Sánchez-Carretero, José Hugo Pires Castro, Paulo Ferreira de Castro, Fernán del Val, Héctor Fouce, Diego García-Peinazo, Leonor Losa, Josep Martí, Eva Moreda Rodríguez, Pedro Russo Moreira, Cristina Cruces Roldán, and Igor Contreras Zubillaga
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 88
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    ASP editions - Academic and Scientific Publishers | UPA
    Publication Date: 2024-04-08
    Description: Continuing the tradition of L’Afrique des grands lacs. Annuaire, this companion volume to Conjonctures de l’Afrique centrale (Paris, L’Harmattan) offers a survey of political developments in Burundi, the Democratic Republic of Congo, Rwanda and Uganda throughout 2019. In Burundi, the year has been marked by the run-up to the 2020 elections. President Nkurunziza announced he would not stand for another term, which could make the contest more open. However, the opposition inside and outside the country remained weak, and political space continued to be constrained. The DRC has been marked by the search for a viable cohabitation between President Tshisekedi’s Cap pour le changement (CACH) and his predecessor Joseph Kabila’s Front commun pour le Congo (FCC). Despite some incidents between these political platforms, the two men have avoided institutional stalemate, but Tshisekedi’s room for manoeuvre has proved limited. Insecurity in the east of the country continues to claim many civilian lives. Rwanda was marked by business as usual, with an autocratic regime suppressing dissident voices and committing considerable human rights abuses. However, technocratic governance remains good. Uganda is gearing up for elections in 2021, and President Museveni will stand for a sixth term, and possibly for a presidency for life. Faced with resistance, the regime is attempting to remain in control, and is doing so heavy-handedly. At the regional level, relations between the DRC and Rwanda have improved, but those between Rwanda on the one hand, and Burundi and Uganda on the other, have remained hostile and marred by serious incidents.
    Keywords: Africa ; politics ; African lakes ; Burundi ; development ; democratic republic of Congo ; Congo ; Rwanda ; Uganda ; elections ; president Nkurunziza ; president Museveni ; president Tshisekedi ; Joseph Kabila ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general::HRAM Religious issues & debates::HRAM2 Religion & politics ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography::RGCP Political geography ; bic Book Industry Communication::1 Geographical Qualifiers::1H Africa::1HF Sub-Saharan Africa::1HFJ Central Africa::1HFJZ Democratic Republic of Congo (Zaire) ; bic Book Industry Communication::1 Geographical Qualifiers::1H Africa::1HF Sub-Saharan Africa::1HFG East Africa::1HFGQ Burundi ; bic Book Industry Communication::1 Geographical Qualifiers::1H Africa::1HF Sub-Saharan Africa::1HFG East Africa::1HFGR Rwanda ; bic Book Industry Communication::1 Geographical Qualifiers::1H Africa::1HF Sub-Saharan Africa::1HFG East Africa::1HFGU Uganda ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAM Religious issues and debates::QRAM2 Religion and politics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGC Human geography::RGCP Political geography ; thema EDItEUR::1 Place qualifiers::1H Africa::1HF Sub-Saharan Africa::1HFJ Central Africa::1HFJZ Democratic Republic of Congo ; thema EDItEUR::1 Place qualifiers::1H Africa::1HF Sub-Saharan Africa::1HFG East Africa::1HFGQ Burundi ; thema EDItEUR::1 Place qualifiers::1H Africa::1HF Sub-Saharan Africa::1HFG East Africa::1HFGR Rwanda ; thema EDItEUR::1 Place qualifiers::1H Africa::1HF Sub-Saharan Africa::1HFG East Africa::1HFGU Uganda ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics
    Language: English , French
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  • 89
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    Bloomsbury Academic | Bloomsbury Academic
    Publication Date: 2024-04-02
    Description: In October 2013, one of the largest anti-migrant riots took place in Moscow. Clashes and arrests continued late into the night. Some in the crowd, which grew to several thousand people, could be heard chanting “Russia for the Russians” with their animus directed towards dark-skinned labor migrants from the southern border. The slogan “Russia for the Russians” is not a recent invention. It first gained notoriety in the very last years of the tsarist regime, appealing primarily to individuals drawn to the radical right. Analyzing a wide range of printed and visual sources, Racism in Modern Russia marks the first serious attempt to understand the history of racism over a span of 150 years. A brilliant examination of the complexities of racism, Eugene M. Avrutin’s panoramic book asks powerful questions about inequality and privilege, denigration and belonging, power and policy, and the complex historical links between race, whiteness, and geography. The ebook editions of this book are available open access under a CC BY-NC-ND 4.0 license on www.bloomsburycollections.com.
    Keywords: Society ; culture ; racial studies ; race ; prejudice ; hate crimes ; modern history ; Russian history ; social history ; discrimination ; anti-racism ; anti-racist ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MR 21st century, c 2000 to c 2100
    Language: English
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  • 90
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    Presses universitaires de Paris Nanterre
    Publication Date: 2022-07-01
    Description: La marchandisation tendancielle de portions grandissantes de la vie humaine et des ressources communes doit-elle être interprétée comme un pillage nuisible et destructeur ou comme un processus collectivement profitable ? Force est de constater qu’elle conduit aujourd’hui à l’extension du domaine des biens privés, au détriment de celui des biens publics et des biens communs. Face à celle-ci s’élabore une série de revendications multiples autour du commun et des communs en vue de contester l’accaparement capitaliste et de promouvoir une gouvernance démocratique de ceux-ci. Que sont les biens communs ? Comment peuvent-ils être légitimement pensés, gérés ? En quoi nous permettent-ils de repenser et de réinstituer le rapport des humains à la propriété, à leur(s) milieu(x), à leur environnement ? Cet ouvrage collectif s’attache à développer ces questions sur les plans d’abord des théories puis des terrains.
    Keywords: bien commun ; appropriation ; capitalisme ; bien public ; propriété ; bien privé ; accaparement ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTG General studies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: French
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  • 91
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: By 2100, more than 80 per cent of the world’s population is expected to live in Afrasia (Africa and Asia). This book draws lessons from history, provides a new cognitive map of the world, and discusses multiple challenges global citizens will face in the age of Afrasia, an emerging macro-region. The centre of gravity of the world is shifting. Whether the world can manage a soft landing into sustainable equilibrium depends on the nature of the dialogue people in Africa and Asia will organise. The author argues that a state of equilibrium between the two is achievable, provided issues related to gender, employment, agriculture, human–nature relationships, and multicultural coexistence are simultaneously addressed. Can future Afrasia present itself as a community determined not to allow the return of predatory practice internally and externally? Will the fates of African and Asian peoples converge or diverge? How about the future relationships between Afrasia and the rest of the world? Exploring these questions using multiple disciplines, this book will be of interest to professional researchers and graduate students in IR and Afro-Asian relations, as well as Asian and African area studies, demography, geography, history, development economics, anthropology, language education, and religious studies.
    Keywords: Politics and government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 92
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    Manchester University Press | Mediterranean quarantines, 1750–1914: Space, identity and power
    Publication Date: 2024-04-02
    Description: This chapter examines the writings of the renowned late-eighteenth-century Moroccan ambassador Ibn Uthmân Al-Meknassî, the first known traveller from his country to leave an account of European quarantine as experienced during his two diplomatic missions in Spain’s Ceuta (1779) and Malta’s Valletta (1782). It shows that quarantine, on the one hand, acted as a marker of otherness by which Ibn Othman was identified as a Muslim, though this was not a uniform process, owing to the fact that significant differences existed in the degree of alterity experienced in Spain and Malta, and indeed other parts of the Mediterranean. The subjective opinion on quarantine, on the other hand, was also one of the means through which Ibn Uthmân situated himself within Makhzen (Moroccan government) elites at a time when a division between those who declared themselves in favour of European-style modernisation and those who advocated a rejection of European novelties was already visible.
    Keywords: ibn uthmân al-meknassî ; spain ; diplomatic missions ; morocco ; 18th century ; quarantine ; malta ; muslim identity ; ibn uthmân al-meknassî ; spain ; diplomatic missions ; morocco ; 18th century ; quarantine ; malta ; muslim identity ; Ceuta ; Epidemic ; Mediterranean Sea ; Tangier ; Travel literature ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine
    Language: English
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  • 93
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: This chapter describes, justifies, presents the pros and cons of and illustrates the use of simulation modeling as a handy, cost-effective and agile tool for policymakers. Simulation modeling is flexible enough to accommodate different levels of detail, precision and time frameworks. It also serves the purpose of a concrete communication platform that facilitates scenario analysis, what-if alternatives and forward looking. We specifically define agent-based modeling within the larger simulation domain, provide a brief overview of other computation modeling methodologies and discuss the concepts of multiple models, verification, validation and calibration. The conceptual framework section closes with a discussion of advantages and disadvantages of using simulation modeling for policy at various stages of implementation. Finally, we present a panorama of actual applications of simulation modeling in policy, with an emphasis on economic analysis.
    Keywords: public administration; policy; future research directions; policy analysis; policy tools; public administration; public management; policymaking; public policy ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration
    Language: English
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  • 94
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    Johns Hopkins University Press
    Publication Date: 2024-04-02
    Description: The Eve of Spain demonstrates how the telling and retelling of one of Spain’s founding myths played a central role in the formation of that country’s national identity. King Roderigo, the last Visigoth king of Spain, rapes (or possibly seduces) La Cava, the daughter of his friend and counselor, Count Julian. In revenge, the count travels to North Africa and conspires with its Berber rulers to send an invading army into Spain. So begins the Muslim conquest and the end of Visigothic rule. A few years later, in Northern Spain, Pelayo initiates a Christian resistance and starts a new line of kings to which the present-day Spanish monarchy traces its roots.Patricia E. Grieve follows the evolution of this story from the Middle Ages into the modern era, as shifts in religious tolerance and cultural acceptance influenced its retelling. She explains how increasing anti-Semitism came to be woven into the tale during the Christian conquest of the peninsula—in the form of traitorous Jewish conspirators. In the sixteenth century, the tale was linked to the looming threat of the Ottoman Turks. The story continued to resonate through the Enlightenment and into modern historiography, revealing the complex interactions of racial and religious conflict and evolving ideas of women’s sexuality.In following the story of La Cava, Rodrigo, and Pelayo, Grieve explains how foundational myths and popular legends articulate struggles for national identity. She explores how myths are developed around few historical facts, how they come to be written into history, and how they are exploited politically, as in the expulsion of the Jews from Spain in 1492 followed by that of the Moriscos in 1609. Finally, Grieve focuses on the misogynistic elements of the story and asks why the fall of Spain is figured as a cautionary tale about a woman’s sexuality.
    Keywords: European history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 95
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 96
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    CNRS Éditions
    Publication Date: 2024-04-02
    Description: À un moment où l’on s’efforce de combler le fossé économique, politique et psychologique qui sépare les rives nord et sud de la Méditerranée, il a paru utile de présenter une pratique peu connue - la caravane maritime - qui a, partiellement, joué ce rôle pendant un siècle et demi. Ce vocable quelque peu inattendu désignait la prestation de service que rendirent, de la fin du XVIIe au début du XIXe siècle, les marins européens aux sujets de l’Empire ottoman. Ils assuraient la plupart des liaisons maritimes pour cette immense construction politique à peu près dépourvue de navires de commerce, bien que bordant la majeure partie du littoral méditerranéen. Après avoir exposé les conditions juridiques qui ont encouragé ce type d’association temporaire, Daniel Panzac présente les marins, la pratique quotidienne de la caravane, avant d’évoquer ensuite les affréteurs ottomans. C’est principalement à travers leurs différends que se révèlent les éphémères relations de ces hommes et leur façon de surmonter leur méfiance et leurs préjugés. Ce faisceau dense de liaisons maritimes favorisa la constitution d’un ensemble économique, une « économie-monde », facteur essentiel de cohésion de cet État aussi vaste qu’hétérogène que fut l’Empire ottoman, ensemble dont l’effondrement dans la première moitié du XIXe siècle précéda l’éclatement politique.
    Keywords: Europe ; commerce ; Empire ottoman ; liaison maritime ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: French
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  • 97
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    Pennsylvania State University Press | University of Pennsylvania Press
    Publication Date: 2024-04-02
    Description: In 1803 in the colonial South American city of La Plata, Doña Martina Vilvado y Balverde presented herself to church and crown officials to denounce her husband of more than four years, Don Antonio Yta, as a "woman in disguise." Forced to submit to a medical inspection that revealed a woman's body, Don Antonio confessed to having been María Yta, but continued to assert his maleness and claimed to have a functional "member" that appeared, he said, when necessary. Passing to América is at once a historical biography and an in-depth examination of the sex/gender complex in an era before "gender" had been divorced from "sex." The book presents readers with the original court docket, including Don Antonio's extended confession, in which he tells his life story, and the equally extraordinary biographical sketch offered by Felipa Ybañez of her "son María," both in English translation and the original Spanish. Thomas A. Abercrombie's analysis not only grapples with how to understand the sex/gender system within the Spanish Atlantic empire at the turn of the nineteenth century but also explores what Antonio/María and contemporaries can teach us about the complexities of the relationship between sex and gender today. Passing to América brings to light a previously obscure case of gender transgression and puts Don Antonio's life into its social and historical context in order to explore the meaning of "trans" identity in Spain and its American colonies. This accessible and intriguing study provides new insight into historical and contemporary gender construction that will interest students and scholars of gender studies and colonial Spanish literature and history. This book is freely available in an open access edition thanks to TOME (Toward an Open Monograph Ecosystem)-a collaboration of the Association of American Universities, the Association of University Presses and the Association of Research Libraries-and the generous support of New York University. Learn more at the TOME website: openmonographs.org.
    Keywords: History ; Latin American Studies ; European Studies ; Feminist & Women's Studies ; Gender Studies ; Law ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSJ LGBTQ+ Studies / topics ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAZ Legal history
    Language: English
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  • 98
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-04-02
    Description: Religion as a form of cultural expression constitutes a critical element in the relationship between Germany and India. The discovery of Indian traditions in Germany and re-interpretations of those traditions in India fueled not only new theological and philosophical explorations, but also extensive innovations in the fields of music, dance, bodily experience, and political intervention. Seeking to uncover the enfolding of colonial thought structures through presentations of the Self, while placing them in the context of global colonial value chains that connected the peripheries with the centre, this interdisciplinary volume addresses India through the lens of an entangled relationship. Adopting the position that the acceleration of communication, technical development, and colonisation locally triggered re-interpretations of the religious sphere, This volume takes a look at the period from 1800 to the end of National Socialism, tracing the strands of an Indo-Germanic religion in the making as it goes along. A special emphasis is placed on the artistic expressions of religious experience including re-enactments of musical compositions and dance configurations, which were created to embody India in Germany. This is an open access book.
    Keywords: Kaiserreich ; Ahmadiyya Islam ; coloniality ; völkisch ; Madame Menaka ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAC Comparative religion ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history
    Language: English
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  • 99
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    Vandenhoeck & Ruprecht
    Publication Date: 2024-04-02
    Description: Ancient Rome has always been considered a compendium of City and World. In the Renaissance, an era of epistemic fractures, when the clash between the 'new science' (Copernicus, Galileo, Vesalius, Bacon, etcetera) and the authority of ancient texts produced the very notion of modernity, the extended and expanding geography of ancient Rome becomes, for Shakespeare and the Elizabethans, a privileged arena in which to question the nature of bodies and the place they hold in a changing order of the universe. Drawing on the rich scenario provided by Shakespeare's Rome, and adopting an interdisciplinary perspective, the authors of this volume address the way in which the different bodies of the earthly and heavenly spheres are re-mapped in Shakespeare's time and in early modern European culture. More precisely, they investigate the way bodies are fashioned to suit or deconstruct a culturally articulated system of analogies between earth and heaven, microcosm and macrocosm. As a whole, this collection brings to the fore a wide range of issues connected to the Renaissance re-mapping of the world and the human. It should interest not only Shakespeare scholars but all those working on the interaction between sciences and humanities.
    Keywords: History ; Europe ; Renaissance ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 100
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
    Language: English
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