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  • thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology  (295)
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  • 2020-2024  (544)
  • 2010-2014
  • 1990-1994
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In recent years, the fascination with shape memory alloys (SMAs) has grown across industries such as aerospace, automotive, naval, civil, and biology. SMAs possess unique properties, including the ability to recover from deformation when heated, exhibit pseudoelastic stress-strain behavior for large deformations, and exceptional biocompatibility for bioengineering applications. However, a comprehensive understanding of critical characteristics like transformation temperature and stress values is necessary to fully utilize SMAs. The shape memory effect, where SMAs regain their original shape after deformation under specific thermal conditions, has driven innovative applications in various sectors. In aerospace, SMAs are used in wing structures and actuation systems, enabling morphing and improving aerodynamics. In healthcare, they are integrated into orthopedic devices, simplifying surgical procedures and providing necessary support. The automotive industry also benefits from SMAs, using them in seatbelts and vibration damping systems for enhanced safety and comfort. Accurate knowledge of critical characteristics is essential for effective utilization of SMAs, unlocking their potential in different fields. The remarkable versatility of SMAs, with their deformation recovery, pseudoelasticity, and biocompatibility, positions them as a material of immense interest. As research and development continue, SMAs are poised to drive future innovations, shaping various industries.
    Keywords: shape memory alloy (SMAs) ; shape memory effect (SME) ; superelasticity ; smart materials ; constitutive models ; simulation and modeling ; smart devices ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mg alloy is the lightest metallic structural material and possesses the advantages of high specific strength, high specific stiffness, good electromagnetism shield, good damping capacity, good machinability, and easy recycling, etc. Therefore, it has extremely broad application prospects and has drawn considerable interest in the fields of automobile, electronics, electrical appliances, transportation, aerospace, and aviation. In addition, Mg alloys are gradually showing application potential in emerging industries, serving as biodegradable metals in the biomedical field, functional material for hydrogen storage, and so on. This Special Issue (SI), entitled “Research Progress in High-Performance Magnesium Alloy and Its Applications”, presents recent developments and excellent results in the field of Mg alloys, and includes 10 articles and one editorial covering some interesting aspects of the topic.
    Keywords: grain refinement ; high strength and toughness ; {10–12} twin ; Mg-Gd-Y alloy ; multidirectional impact forging ; Mg-Zn-Mn-Ca ; Ca2Mg6Zn3 phase ; corrosion behaviors ; SKPFM ; boride ; MgB2 ; mechanical alloying ; ignition ; combustion ; flame temperature ; magnesium alloy ; biocompatibility ; surface coating modification ; corrosion resistance ; implantable bio-metal materials ; filler material ; welding ; scandium ; microstructure modification ; mechanical properties ; microstructure ; texture ; stretch formability ; high temperature cross-rolling ; annealing ; wire arc additive manufacturing ; cold metal transfer ; Al-Mg alloys ; orthogonal experiment ; Mg-Bi-Ca alloy ; hot deformation ; constitutive model ; dynamic recrystallization kinetics ; Mg alloy ; twinning ; random orientation ; compression ; room temperature ; backward extrusion ; tensile strength ; failure mechanism ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Supply Chain 4.0 is designed, planned, managed and optimized using Industry 4.0 technologies. There are many research issues and challenges associated with Supply Chain 4.0, a data rich complex system. The available data can interpret what happened in the past, what is currently happening, what will happen in the future and what are the best actionable decisions. Digitalization, visibility, connectivity and interoperability are integrated in Supply Chain 4.0. The operational, tactical and strategic plans across the supply chain are digitally interlinked and real-time synchronized with a 360-degree view. The win–win partnerships are dynamic and sustainable, with agility, flexibility and responsiveness to uncertain business environments. New models and methods are advocated to implement Supply Chain 4.0 research and development. With the progress and implementation of Industry 4.0 technologies, it is anticipated that there will be more and more breakthroughs in the models and methods of Supply Chain 4.0. This Special Issue will serve as a helpful reference for Supply Chain 4.0 researchers and practitioners.
    Keywords: Industry 4.0 ; supply chain management and optimization ; Supply Chain 4.0 ; supply chain analytics ; supply chain visibility and connectivity ; supply chain synchronization and coordination ; sustainable supply chain management&nbsp ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The ongoing deployment of 5G networks is a key enabler for realizing upcoming services at scale, including the massive deployment of the Internet of Things, providing communications to support autonomous vehicles, and supporting the realization of smart cities. However, as the limitations of existing approaches become apparent, the need for next-generation technologies is growing, in terms of improving spectral efficiency, increasing network data rates and densification, supporting local/wide area wireless coordination, and more. In this Special Issue, we present some technologies to meet these demanding requirements and facilitate coordinating wireless networks to support future Beyond 5G networks.
    Keywords: 5G fiber optic networks ; data-driven service assurance ; next generation networks ; predictive analytics ; live-video delivery ; 5G networks ; virtualized content delivery networks ; network function virtualization ; service function chain deployment ; deep reinforcement learning ; MAC classification ; vehicular networks ; VANETs ; distributed MAC ; centralized MAC ; multi-channel MAC ; single-channel MAC ; spectrum allocation ; private 5G ; mmWave RAN ; modulation and coding schemes ; spectral efficiency ; self-organization ; self-optimization ; self-healing ; SON applications and architecture ; SON design and dimensioning ; machine learning (ML) and artificial intelligence (AI) for SON ; massive Machine-Type Communication (mMTC) ; IoT ; URLLC ; backhauling ; SON for 3G/4G ; 5G and B5G networks ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Energy is an important material basis that can promote the development of human society. Despite the increasing use of renewable energy, the overall energy supply is dominated by fossil fuels. For a long period of time, the main consumption proportion of fossil energy will not change. With the perspective of fossil fuels such as coal, oil, natural gas, shale oil, shale gas, and combustible ice, energy exploration, reservoir reconstruction, and intelligent applications in energy exploitation and energy occurrence geology are currently explored from the perspectives of exploration and exploitation technology. This reprint summarizes the intelligent unmanned mining and its development trends and conducts various research studies, including the stratigraphic correlation of sandy conglomerate in the Yellow River Delta Sag of the Bohai Bay basin, the growth and distribution of coal-measured hydrocarbon source rocks in a mixed platform, the physical and mechanical properties of sandstone, mudstone and granite in the geological environment of deep energy reservoirs, the formation mechanism of energy reservoirs and gas reservoirs, the two-phase flow experiment and numerical simulation in energy mining, the evolution law of cracks in the surrounding rock and the reinforcement principle of gradient support, and the comparison of particle pickup by axial flow and swirling flow in horizontal pneumatic conveying.
    Keywords: intelligent mine ; smart mining ; intelligent working face ; intelligent control ; adaptive ; robotic technology ; seismic rock physics ; sandstone and mudstone ; P-wave and S-wave velocity ; pressure ; temperature ; sandy conglomerate ; Huanghekou Sag ; stratigraphic correlation ; calcite U-Pb dating ; detrital zircon ; pressure-controlled pyrolysis ; oil–water separation ; centrifugal force ; two-phase vapor separation ; cyclone separation ; Tarim Basin ; mixed platform ; delta ; coal-measure distribution ; coal-measure logging response ; axial flow ; swirling flow ; pickup behavior ; coefficient of variation ; tight sandstone gas reservoir ; nuclear magnetic resonance ; fracture ; water blocking ; n/a ; rock mechanical properties ; MMTS ; geothermal development ; geothermal reservoir ; different depth of occurrence ; gas storage ; injection production simulation ; effective permeability ; seepage law ; two-dimensional simulation experiment ; fracture evolution law ; fractured seepage zone ; gradient failure support ; hierarchical control mechanism ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint focuses on basic and applied research on fatigue and fracture processes in engineering of materials and composites. Special attention is given to understanding fracture processes from the point of view of micro and nano damage mechanisms related to material microstructure. Advanced experimental methods such as tomography, digital image correlation, high resolution electron microscopy and fractography are applied in combination with theoretical multiscale models based on finite element methods and fracture mechanics to reveal the fundamental causes of material failure.
    Keywords: cyclic indentation ; Vickers hardness ; inverse analysis ; numerical simulations ; cyclic material properties ; fatigue life ; advanced high-strength steels ; hydrogen embrittlement ; in-situ testing ; scanning electron microscopy ; plasma charging ; coarse-grained Ni-based superalloys ; crystal plasticity ; notch effect ; strain concentration factor ; hull fracture ; inspection manholes ; bulk carrier ; cracks ; corrosion fatigue ; steel quality ; cleavage fracture ; finite element analysis ; local approach ; Weibull stress ; synchrotron tomography ; short fatigue crack growth ; residual stress ; very high cycle fatigue ; silicon carbide ; ceramic matrix composites ; creep properties ; high-temperature strength ; molecular dynamics ; artificial neural network ; forged titanium alloy ; low-cycle fatigue ; cycle wave form ; durability ; crack meso-tunneling ; fractography ; crack growth duration ; ultrasonic fatigue ; frequency effect ; strain rate effect ; environmental effect ; size effect ; high cycle fatigue ; underload cycles ; crack closure ; threshold ; fatigue crack growth ; oxidation ; EA4T steel ; fracture ; gigacycle fatigue ; surface morphology ; kinetic equation ; laminated metallic composites ; toughening mechanisms ; interfaces ; fatigue crack propagation ; large chamber SEM ; ultra-high steel grades ; tensile characteristics ; fracture toughness ; temperature dependence ; modelling fracture ; ductile-to-brittle transition ; local approach to fracture ; ferritic steel ; synchrotron radiation X-ray imaging ; fatigue performance ; fatigue crack ; FGH96 alloy ; microstructure ; micro-indentation ; mechanical and fracture properties identification ; optimisation analysis ; 316L stainless steel ; selective laser melting ; fatigue damage ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: We invite you to read the Special Issue on innovation for sustainable business. It is a collection of 7 articles published in a Special Issue of Sustainability MDPI in 2021-2022. Many of the articles in this reprint are related to leadership. In the context of sustainable development, issues such as dynamic capabilities, CSR, succession management and innovative projects were addressed. Sustainable innovation is also considered from other perspectives. One of them is the topic of introducing sustainable innovations to new ventures. In addition, drivers and impacts of eco-innovation were also examined. There was also research in the area of ​​live commerce, which includes the perspective of consumer behavior.
    Keywords: dynamic capabilities ; eco-innovation ; leadership ; corporate social responsibility ; the attitude of future managers towards CSR ; ethical aspects of companies’ operations ; sustainability ; green technologies ; environmental innovation ; industry ; Brazil ; capability ; organization ; survival ; workforce ; live commerce ; hunger marketing ; perceived trust ; perceived value ; impulse buying behavior ; Sustainable Industry 4.0 ; innovative projects ; interdisciplinarity ; project team competencies ; sustainable innovation ; knowledge search ; organizational learning ; strategic flexibility ; new ventures ; QCA ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint focuses on the position of sustainability in engineering and points to the multidimensionality of the issue. Architecture, civil and engineering issues are main themes of discussion, with special attention to research and design. Attention is focused on four thematic groups: energy (including energy harvesting), economy (including building circularity), pro-health activities, and design.
    Keywords: CFD ; mechanical ventilation ; industrial buildings ; thermal comfort ; air quality ; natural environment ; construction sector ; steel ; sustainable development ; cradle-to-gate with options ; Life Cycle Assessment ; life cycle costs ; maintenance costs ; warranty period ; number of use cycles ; building circularity assessment ; material flow model ; building circularity material passport ; building circularity calculation method ; adaption ; landscape pattern ; local microclimate ; comprehensive analysis ; morphological parameters ; space syntax ; façade configuration ; visual perception ; built heritage ; Kaunas ; cultural sustainability ; PV system ; social acceptability ; system dynamics ; CO2 emissions ; feed-in-tariffs ; subsidy policy ; water management ; housing environment quality ; multi-family settlements ; Bio-Morpheme ; greenery ; automated design ; plant selector ; sustainability ; algorithmic design ; landscape design ; BIM ; green BIM ; city breathability ; urban ventilation ; urban air quality management ; blue-green infrastructure ; integrated urban planning ; economic analysis ; marketplace regeneration ; optimisation ; spatial analysis ; urban design ; vibration ; energy harvesting ; green gardens ; multifunctionality ; plus-energy building ; thermal stack ; solar energy ; integrated design ; prefabricated rural housing ; PEST ; entropy weighted TOPSIS ; implementation potential ; Chongqing ; n/a ; urban planning ; building layout ; energy demand ; climate ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
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  • 18
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mountains encompass more than 30% of all land and 23% of the Earth’s forests, with high levels of biodiversity and endemism, and they support diverse habitats and refuges for approximately 85% of amphibian, bird, and mammal species. More than 1/4 of the global human population inhabits mountain environments, many of whom are among the world’s poorest people. The climate and anthropogenic changes have had a tremendous impact on biodiversity and ecosystems around the world. On the Qinghai–Xizang Plateau, which is characterized by a low temperature, short growing season, and diverse ecosystems, global changes such as the warming climate might reduce biodiversity and alter ecosystem functions. This reprint contains studies with a focus on the Qinghai–Xizang Plateau and the south-west mountainous areas of China. The topic deals with the application of multiscale methods and approaches in the context of biodiversity, from the scale of genes and individuals to ecosystems and landscapes, including the adaptations of organisms, like plants, birds, and micro-organisms, spatial–temporal variations in vegetation patterns and land use statuses, and the possible driving factors of the functional adaptation of organisms to climate and anthropogenic changes.
    Keywords: adaptation ; biogeography ; ecosystem functions ; functional traits ; genetic and species diversity ; global change ; landscape heterogeneity ; mountain environment ; NDVI ; sustainable development&nbsp ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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  • 19
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    The MIT Press | The MIT Press
    Publication Date: 2024-04-14
    Description: How Bulgaria transformed the computer industry behind the Iron Curtain—and the consequences of that transformation for a society that dreamt of a brighter future.Bulgaria in 1963 was a communist country led by a centralized party trying to navigate a multinational Cold War. The state needed money, and it sought prestige. By cultivating a burgeoning computer industry, Bulgaria achieved both but at great cost to the established order. In Balkan Cyberia, Victor Petrov elevates a deeply researched, local story of ambition into an essential history of global innovation, ideological conflict, and exchange. Granted tremendous freedom by the Politburo and backed by a concerted state secret intelligence effort, a new, privileged class of technical intellectuals and managers rose to prominence in Bulgaria in the 1960s. Plugged in to transnational business and professional networks, they strove to realize the party's radical dreams of utopian automation, and Bulgaria would come to manufacture up to half of the Eastern Bloc's electronics. Yet, as Petrov shows, the export-oriented nature of the industry also led to the disruption of party rule. Technicians, now thinking with and through computers, began to recast the dominant intellectual discourse within a framework of reform, while technocratic managers translated their newfound political clout into economic power that served them well before and after the revolutions of 1989.Balkan Cyberia reveals the extension of economic and political networks of influence far past the reputed fall of communism, along with the pivotal role small countries played in geopolitical games at the time. Through the prism of the Bulgarian computer industry, the true nature of the socialist international economy, and indeed the links between capitalism and communism, emerge.
    Keywords: Computer Science/History of Computing ; Science, Technology & Society/History of Technology ; Economics/Economic History ; Business/Business Technology ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
    Keywords: chronic rhinosinusitis ; B-cell lymphoproliferative disorder ; sinus ; nasal allergies ; tannery worker ; Kanpur ; asthma ; ovalbumin ; saffron ; salbutamol ; IL’s ; TNF-α ; allergic rhinitis ; bronchial asthma ; allergy ; Th17 cells ; IL-17 ; IL-33 ; microRNA ; miR ; airway mucosal inflammation ; united airway disease ; acute rhinosinusitis ; acute recurrent rhinosinusitis ; Mediterranean diet ; nutritional evaluation ; nutritional therapy ; olfactory dysfunction ; anosmia ; post-acute COVID-19 ; nitric oxide ; NO ; exhaled NO ; FENO ; nasal peak flow ; atopic status ; total IgE ; specific IgE ; childhood asthma ; immunoblot ; ImmunoCAP ; otolaryngology ; sinusitis ; ethnic groups ; patient-reported outcome measures ; quality of life ; social justice ; n/a ; bic Book Industry Communication::M Medicine
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
    Keywords: model-informed precision dosing (MIPD) ; efficacy PKPD indexes ; pharmacokinetics ; pharmacodynamics ; PKPD modeling and simulation ; dosing algorithms ; nomograms ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented.
    Keywords: ferulic acid ; total body irradiation ; bone marrow microenvironment ; stem cell senescence ; bone marrow injury ; reactive oxygen species ; antioxidant defense system ; planarians ; model animal ; irradiation ; regeneration ; radioprotection ; radiation ; melatonin ; nDNA-repair ; mtDNA-mutations ; oxidation stress ; protection ; mitigation ; H2O2 ; ATP ; MDA ; GSH ; X-ray radiation ; 3T3 fibroblasts ; proliferation ; apoptosis ; cellular stress ; senescence ; peroxiredoxin 6 ; Prdx6 ; radioprotector ; pharmacologic ascorbate ; vitamin C ; pancreatic cancer ; Auranofin ; thioredoxin ; thioredoxin reductase ; peroxiredoxin ; nuclear and radiological emergencies ; radioprotectors ; radiomitigators ; radionuclide scavengers ; radiation biodosimetry ; Olea europaea L. cv. Caiazzana ; oleacein ; ionising radiation ; cancer ; radiotherapy ; normal tissue ; radiosensitization ; radiomodulation ; proteomic analysis ; oxidative modification profiling ; serum albumin ; amino acid sequences ; radiation biomarker ; human lactoferrin ; acute gamma irradiation ; C57Bl/6 mice ; survival rate ; open field test ; spleen ; serum homeostasis ; leukocytes ; stilbenoid ; electron paramagnetic resonance (EPR) ; FT-IR ; electron beam radiation ; radioresistance ; oxidative phosphorylation ; oncometabolites ; radiation response ; bioinformatics ; oxidative stress ; transcriptomics ; radiobiology database ; gene signature ; ionizing radiation ; intestine ; mucositis ; microbiome ; microbiota ; dysbiosis ; bacterial dietary supplement ; radiomitigator ; hyperthermia ; combination therapy ; synergistic effect ; oxygenation ; hypoxia ; immune response ; Tameron ; antioxidant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 23
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: This reprint presents groundbreaking discoveries, practical techniques, and rigorous analyses related to the cultivation, preparation, and exploitation of mycelium composites. The papers cover a wide range of topics, including functional modifications of mycelium with inorganic particles, modifying and assessing the mechanical properties of mycelium composites, strategies for improving the flexural behaviour of composites, beehives from fungal materials, bio-welding and reinforcement of composites, bioreactors for fungal production, co-production of composites by fungi and bacteria, growing large-scale mycelium structures, sound absorption by composites, and the geometrical parameterisation of fungi. This informative compendium of techniques, methods, and insights on growing fungal material appeals to readers from all walks of life, from high school pupils to university professors, from mathematicians, computer scientists, and engineers to chemists, from craft practitioners to industrial producers of fungal materials, and from biologists to architects and artists.
    Keywords: mycelium-based composites ; additive manufacturing ; bio-based materials ; circular construction ; digital fabrication ; mycelium ; bio-composites ; bio-fabrication ; ultrasonic welding ; wood printing ; robotic fabrication ; reinforced composites ; natural fiber reinforced polymers ; NFRP ; growing materials ; rattan ; lightweight structure ; architecture ; structural design ; computational design ; subtractive manufacturing ; circular economy ; compressive structures ; compressive strength ; digital image correlation ; masonry ; growth ; mechanical properties ; materials science ; mycelium-based composite ; biomaterials ; natural composites ; bacterial cellulose ; biocompatibility ; knitted fabric ; material tinkering ; lignocellulosic fibers ; natural fiber reinforcement ; mechanical characteristics ; manufacturing variables ; nanoclay ; fungal fruiting bodies ; parametric design thinking ; plasticity ; linearity ; non-linearity ; biohybrid architecture ; bio fabrication ; living architecture ; beehive ; 3D printing ; mycelium materials ; symbiosis ; multispecies architecture ; healthy materials ; binding capacity ; bio-adhesives ; building biomaterials ; fungal mycelium ; mechanical performance ; acoustic materials ; sound absorption ; fungal architecture ; myceliated material ; living material ; sustainability ; biotechnology ; compression ; bending ; waste upcycling ; mycoremediation ; myco-materials ; myco-fabrication ; sustainable buildings ; sustainable structures ; architectural design ; material ethics ; modular chain bioreactor ; solid-state fermentation ; mycelium production ; Ganoderma lucidum ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases.
    Keywords: household air pollution ; fine particulate matter ; international environmental health ; cookstove ; respiratory disease ; brick worker ; particulate matter ; heavy metals ; Sulfate-Nitrate-Ammonium ; pollution levels ; mobile sources ; aerosols ; PAHs ; OC and EC ; transport sources ; urbanized coastal station ; grain dust ; health risk assessment ; Monte Carlo simulation ; disability adjusted life year ; multi-media exposure ; health risk ; probabilistic risk assessment ; Lake Chaohu ; PM10 ; health risks ; extreme learning machine ; echo state network ; neural networks ; pollution ; concentration ; indicators ; aberrant values ; nitrogen oxides ; ARIMA ; GRNN ; ARIMA–GRNN ; isolation forest ; LOF ; AOD ; classification ; dendrogram ; PCA ; air quality index ; polluting agents ; respiratory diseases ; monitoring stations ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: This reprint focusses on Smartness, a multidisciplinary topic, which is examined from four perspectives: Sensors, IoT, and Data Generation; Data and Information Processing; Actuation; and Digital Systems and Infrastructure. We see smartness in the way sensing is embedded in a system, the way data and information are processed, how a system interacts internally and with its environment, and whether a system is ubiquitous or limited by space (cloud-based or edge-enabled). This reprint contains a total of 14 chapters, which are grouped according to their areas of application: mobility and transportation, healthcare, industrial environments, and other urban infrastructures. This book covers a range of topics, including mobility; healthcare; image analysis; permeable pavements; solid-waste management; sensor node and gateway architectures; cloud, fog, and edge computing; air-quality monitoring; thermal anomalies and smart helmets in industrial environments; smart airports; smart districts; smart travel choices; sensor cities; artificially intelligent cities; platform urbanism; and more.
    Keywords: artificial intelligence (AI) ; artificially intelligent city ; artificially intelligence commons ; smart city ; smart urban technology ; urban informatics ; sustainable urban development ; climate change ; pandemics ; natural disasters ; sensor city ; City 4.0 ; smart urbanism ; smart governance ; disruptive urban transition ; Internet-of-Things (IoT) ; technology giants ; sensors ; transit ; bus ; transfer ; smart card ; spatial analysis ; mode choice ; internet of everything (IoE) ; 6th generation (6G) networks ; artificial intelligence ; Distributed AI as a Service (DAIaaS) ; fog computing ; edge computing ; cloud computing ; smart airport ; smart districts ; PPE ; OHS ; risk detection ; naive Bayes ; support vector machine ; convolutional neural network ; deep learning ; microcontroller ; edge-fog-cloud computing ; Internet of Things ; robotics ; autonomous driving ; image registration ; smart sensor ; real time big data ; land-use ; air quality ; particulate matter (PM10 PM2.5) ; Intelligent Transportation Systems ; functional requirements ; machine learning ; model actionability ; model evaluation ; cloud server ; customized sensor node ; customized gateway ; FLoRa simulation ; LoRa range radio ; solid waste management ; smart cities ; big data ; event detection ; road traffic ; distributed machine learning ; automatic labeling ; social media ; data analytics ; social media analytics ; Arabic tweets ; 3D microstructure reconstruction ; permeable pavement ; generative adversarial networks ; tiny AI ; tiny ML ; distributed AI as a service (DAIaaS) ; skin disease diagnosis ; healthcare ; smart societies ; smart healthcare ; reference architecture ; TensorFlow ; visually impaired ; smart mobility ; LiDAR ; ultrasonic ; obstacle detection ; obstacle recognition ; assistive tools ; green computing ; sustainability ; Arduino Uno ; smart app ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: There has been a rapid development in the academic literature over the last ten years on papers relating to individualization, personalization, patient-, client-, consumer- and person-centredness, with work on conceptual, instrumental, observational, and experimental levels. This Special Issue presents papers that can further establish the current state of science on these topics relating to personalized nursing and health care. We collected papers that highlight and further the knowledge base conceptually, instrumentally, observationally, and experimentally with sound theoretical and methodological underpinnings and implications for research, theory, and clinical work in the disciplines of nursing, medicine, allied health, and beyond.
    Keywords: anxiety ; life satisfaction ; life–work concerns ; melatonin ; cortisol ; biopsychosocial model ; obstetric complications ; patients’ rights ; student ; nursing ; personalized medicine ; HIV ; mobile health ; smartphone application ; symptom management ; nurse practitioners ; nursing home ; COVID-19 ; palliative care ; end-of-life ; dignified death ; older adults ; accidental falls ; fall prevention ; barriers ; patient compliance ; music therapy ; dementia ; caregiver ; RCT ; patient-centred care ; competence ; assessment ; instrument ; measurement ; validity ; reliability ; individual care ; nurses ; older diabetes patients ; physicians ; support ; Parkinson’s disease ; nursing training ; integrated care ; Parkinson nurse ; personalized care ; multidisciplinary care ; patient-centered ; arthritis ; autoimmune disease ; sociopsychological factors ; emotion ; depression ; self-identity ; qualitative study ; observational study ; dysmenorrhea ; kinesio tape ; auricular acupressure ; pain ; nursing care ; patient care planning ; quality of health care ; conditional inference trees ; education ; distance ; learning ; digital ; drawings ; Nigeria ; perinatal loss ; social networks ; stillbirth ; stillborn ; functional status ; health care ; hospitalization ; activities of daily living ; pelvic floor muscle exercises ; pelvic floor dysfunction ; qualitative research ; therapeutic exercise ; therapeutic adherence ; women’s health physiotherapy ; diabetes mellitus type 2 ; prediction model ; LogicRegression ; interpretability ; pelvic organ prolapse ; lifestyle changes ; women’s experience ; n/a ; foot ; foot self-care ; methodological review ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Dry pasta is one of the most popular staple foods worldwide due to its convenience in terms of affordability, versatility, long shelf life, as well as sensory and nutritional value. As such, it represents a suitable carrier for health-promoting substances providing specific physiological functions. This Special Issue deals with the continuum aspects, “from seed to fork”, that could have an impact on the nutritional, sensory, and technological aspects of pasta. In this Special Issue, we aimed to publish innovative research and review papers on physico-chemical and sensorial characteristics, nutritional value, functional and technological properties of pasta, and pasta-making processes. New raw materials, new functional ingredients, up-cycling of waste materials, in vivo experiments to test the effect of assumption of the supplemented pasta, and innovative packaging systems will also be addressed in this Special Issue. Predictions of pasta quality adopting chemometrics as well as multi-variate and statistical data analysis approaches were welcomed. Finally, in the medium term, the international pasta market is expected to stay negative unless tangible product innovations are introduced, particularly regarding the technological innovations aimed at improving the products’ health benefits. This Special Issue aimed to provide a fundamental understanding and present the current strategies to improve the technological, nutritional, and sensory properties of pasta.
    Keywords: innovative pasta raw materials ; durum ; emmer ; spelt ; pasta ; brewers’ spent grain ; dietary fiber ; einkorn ; functional pasta ; tritordeum ; upcycling ; unconventional ingredients ; nutritional value ; cooking quality ; legumes ; Spirulina Platensis ; resistant starch ; hydrolysis index ; dietary fibre ; annealing ; slowly digestible starch ; carbohydrates ; fiber ; in vitro digestion ; micronization ; brown rice ; air fractionation ; parboiling ; rice pasta ; enriched pasta ; bioactive compound ; tuna ; sea bass ; Ω-3 fatty acids ; sensometrics ; TPA (texture profile analysis) ; glycemic index ; glycemic response ; durum wheat ; landraces ; starch ; available carbohydrates ; glycemic load ; texture profile analysis ; gluten-free ; celiac disease ; fish ; allergy ; pear, date, and apple by-products ; wheat flour ; sensorial properties ; scanning electron microscopy ; multiple factor analysis ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated.
    Keywords: RSV ; ectodomain G protein ; heparan sulfate ; protein–ligand interaction ; fluorescence quenching ; molecular docking ; molecular dynamic simulation ; quercetin ; CCL4 ; neurotoxicity ; VirtualToxLab ; oxidative stress markers ; Huperzine A ; molecular dynamics simulation ; fluorescence spectroscopy ; human serum albumin ; neurodegenerative disorders ; drug–protein interactions ; erlotinib ; bovine serum albumin ; binding interaction ; competition ; hepatitis E virus ; methyltransferase ; protein stability ; enzyme assay ; garlic ; antioxidant ; anti-glycation ; glycation ; AGEs ; HSA ; quetiapine ; hydrophobic interaction ; thermodynamic parameters ; seproxetine ; antidepressant ; charge transfer ; π-acceptors ; DFT ; haloperidol ; antipsychotics ; keratoconus ; MMP-2 ; MMP-9 ; molecular dynamics ; MM-GBSA calculations ; pharmacophore mapping ; α-amylase ; advanced glycation end-products ; caffeic acid ; coumaric acid ; coronary artery disease ; phytotherapy ; network pharmacology ; angiogenesis ; zebrafish ; dynamics molecular docking ; NEK7 ; virtual screening ; DFTs ; deep learning ; drug design ; drug repurposing ; structural-based ; cancer ; A. aspera ; β-amyrin ; C. gigantea ; C. procera ; GC-MS ; Minimum inhibitory concentration (MIC) ; Molecular docking ; MD simulations ; Tuberculosis (TB) ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 29
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Buildings are important consumers of energy; in fact, they represent 30–45% of the global energy use and one-third of total greenhouse gas emissions, as well as contributing to the urban heat-island effect. In consequence, the correct design and execution of buildings, use of new materials that reduce energy demand, and efficient use of renewable energy are all necessary to reduce the impacts that occur during their life-cycle. This book shows some examples, focused on improving the energy-efficiency of buildings, in accordance with circular economy policies and life-cycle phases, including design, construction and use. The editor wishes to thank all the authors for contributing to this book, as well as to the assistance of MDPI’s editorial office.
    Keywords: climate-oriented ; buildings ; building construction ; climate zones ; climate change ; bibliometric ; climate zone ; building ; energy demand ; building resilience ; air quality ; air pollution ; SUNSPACE ; PM removal ; azure chemistry ; circular economy ; sustainability ; SDG 11 ; SDG 12 ; buying intention ; energy-efficient home appliances ; green self-identity ; theory of planned behavior ; waste glass ; light reflectance ; building material coatings ; soda–lime–silica glass ; lead–silica glass ; cool surface ; cool material ; cool roof ; urban heat island ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint includes 22 research papers and an editorial, collected from the Special Issue "Modelling, Monitoring, Control and Optimization for Complex Industrial Processes", highlighting recent research advances and emerging research directions in complex industrial processes. This reprint aims to promote the research field and benefit the readers from both academic communities and industrial sectors.
    Keywords: open-die forging ; reinforcement learning ; double deep Q-learning ; process design ; process optimization ; RTO ; data reconciliation ; natural gas processing ; economic evaluation ; sequential-modular approach ; electric vehicle ; charging station ; photovoltaic ; maximum power point tracking ; data-driven ; state prediction ; fault classification ; multi-agent system ; parameter acquisition ; mechanism model ; forging machine ; continuous stirring reactors ; fault detection ; T-S fuzzy model ; channel fading ; performance optimization ; steam generator level control ; knowledge-informed simplex search method ; historical iteration information ; iteration termination control ; TLSCA-SVM ; optimization method ; fault diagnosis ; transfer learning ; porous structure ; finite element analysis ; CAD ; centroidal Voronoi diagram ; block cutting ; data reconstruction ; convex polyhedron (CPH) ; convex polygon (CPG) ; path optimization ; average material removal rate (AMRR) ; permanent magnet synchronous motor ; characteristic model ; linear golden-section adaptive control ; model-based design ; dividing-wall distillation column ; genetic algorithm ; temperature inferential control ; temperature difference ; quality estimator ; discrete element method ; particle modelling ; multi-sphere method ; simulation analysis ; anti-corrosion pill particle ; leakage current ; common-mode voltage ; model predictive control ; transformerless inverter ; H8 ; weak grid ; hyperchaotic complex system ; tracking control ; fractional order ; mathematical modeling ; production scheduling ; advanced optimization methodologies ; modeling of industrial processes ; VSM ; durability ; logistics 4.0 ; methodology ; automobile ; wiring ; wind farms ; inspection ; path planning ; chaotic neural network ; time delay ; bidirectional free-riding ; differential game ; bilateral cost-sharing decisions ; artificial intelligence (AI) ; music generation ; natural language processing ; transformer ; GANs ; green growth ; influencing factor ; factor identification ; DEMATEL method ; manufacturing enterprises ; resilient dynamically triggering controller (DTRC) ; dynamically triggering mechanisms (DTMs) ; denial-of-service (DoS) ; networked nonlinear systems (NNSs) ; resilient dynamically event-triggering (RDET) ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This book presents a collection of papers revealing the impact of advanced computation and instrumentation on healthcare. It highlights the increasing global trend driving innovation for a new era of multifunctional technologies for personalized digital healthcare. Moreover, it highlights that contemporary research on healthcare is performed on a multidisciplinary basis comprising computational engineering, biomedicine, biomedical engineering, electronic engineering, and automation engineering, among other areas.
    Keywords: eHealth ; mHealth ; telemedicine ; telehealth ; social sciences ; bibliometrics ; telediagnostic ; project management ; funding ; IT infrastructure ; cross-border multiprofessional team ; European Union ; Interreg ; reporting ; quality control ; resident ; diagnostic error ; artificial intelligence ; healthcare AI ; deployment and scaling ; medical center ; critical factors ; stakeholders ; health information technology ; information sharing ; hospital costs ; poverty ratio ; concentration ; continuous glucose monitoring ; insulin pump ; continuous subcutaneous insulin infusion ; pediatric diabetes ; biomedical data ; medical imaging ; shared data ; massive databases ; AI-based healthcare solutions ; trueness ; 3D printing ; milling ; interim dental crown ; digital dentistry ; dental device ; data mining ; bio-signal analysis ; bio-signal repository ; execution engine ; bio-signal monitoring ; digital healthcare ; patient-centric ; blockchain ; federated learning ; coronavirus (COVID-19) ; pandemic management ; healthcare transformation ; public health strategies ; stroke detection ; portable head scanner ; low-intensity EM waves ; intrinsically safe ; low carbon footprint ; orthodontic treatment ; clear aligners ; smart application ; AI ; computerized learning ; behavior change techniques ; decision tree algorithm ; digital interventions ; mental health literacy ; audiovisual ; dentistry ; computer-controlled local anesthetic delivery ; ultrasounds ; chemomechanical caries removal ; modern technologies ; laser ; ozone ; healthcare ; emergency department ; patient flow ; simulation modeling ; agent-based modeling ; pandemic decision support ; additive manufacturing ; patient-centric dosage form ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Twelve edited original papers on the latest and state-of-art results of topics ranging from calibration, validation, and science to a wide range of applications using ALOS-2/PALSAR-2. We hope you will find them useful for your future research.
    Keywords: Sentinel-1 ; ALOS/PALSAR-2 ; land subsidence ; accuracy assessment ; Alexandria City ; Egypt ; local climate zone ; random forest ; feature importance ; land surface temperature ; grid cells ; Sentinel-2 ; PALSAR-2 ; ASTER ; soil moisture ; ALOS-2 ; GA-BP ; water cloud model ; L-band ; SAR ; backscattering ; soil moisture content ; LAI ; HH and HV polarization ; flood ; NoBADI ; Florida ; Hurricane Irma ; synthetic aperture radar ; polarimetric radar ; co-polarized phase difference ; radar scattering ; vegetation ; radar applications ; agriculture ; leaf area index ; leave-one-out cross-validation ; oil palm ; radar vegetation index ; vegetation descriptors ; ecosystem carbon cycle ; L-band SAR ; vegetation index ; random forest regression ; plantation ; permafrost ; InSAR ; Qinghai-Tibet Plateau ; ALOS ; thermal melting collapse ; Sentinel-1A ; SBAS-InSAR ; heavy forest area ; potential landslide identification ; SAR-based landslide detection ; Growing Split-Based Approach (GSBA) ; Hokkaido landslide ; Putanpunas landslide ; SAR polarimetry ; model-free 3-component decomposition for full polarimetric data (MF3CF) ; radar polarimetry ; calibration ; Faraday rotation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In the last decade, design and material innovations for manufacturing composites have reached new heights. Thermoplastic polymers and their composites have become the most in-demand materials in recent times as they provide numerous advantages over thermoset composites. Thermoplastic polymers have a high damage tolerance, high impact resistance, recyclability, formability, weldability, repairability, and cost-effectiveness compared with thermoset composites. Thermoplastic polymers and composites are widely used in automotive, aerospace, electrical and electronics, industrial, and medical applications. Thermoplastic composites are estimated to grow from USD 28.0 billion in 2019 to USD 36.0 billion by 2024. High-performance thermoplastic materials are used in conjunction with a multitude of manufacturing processes like injection moulding, thermoforming, prepreg, liquid injection processes, automated tape placement, filament winding, pultrusion, additive manufacturing, and other processes. The material limits, design, and assembly requirements, as well as the processing constraints, are significantly important for the realisation of novel product development using a manufacturing process by simultaneously optimising reliability, safety, and other performance-related issues. The current thermoplastic material systems and manufacturing techniques still have plenty of room for optimisation and advancement. This reprint presents the latest scientific and technical advances in thermoplastic materials and their composites, processing, characterisation, product development, and manufacturing process parameter optimisations.
    Keywords: thermoplastic composites ; automated tape placement ; fibre misalignment ; voids ; CT scan ; circular distribution ; textured surface ; scratch ; scratch resistance ; thermoplastic polymer ; finite element modelling ; antimicrobial ; metallic ions ; ligand ; copper nanoparticles ; polypropylene ; thermoplastic resin ; process modeling ; filament winding ; automated fiber placement ; EWF ; polymer-layered silicates ; oMMT ; clay minerals ; mechanical properties ; nanocomposite ; physio-thermo-mechanical properties ; polyurethane ; polymers ; bio-applications ; energetic binder ; block copolyurethane ; sensitivity ; mechanical property ; thermal behavior ; bone scaffold ; recycled bone powder ; chitosan ; PLA ; PCL ; antibacterial activity ; aircraft cabin interior panels ; optimal curing of prepregs ; foams ; non-structural composite panels ; thermoplastic starch ; nanocomposites ; biopolymers ; properties ; packaging ; nanofiller ; vacuum forming ; thermoplastic face sheets ; polyphenylene sulfone ; cardo fragments ; IR spectroscopy ; heat resistance ; thermostability ; FDM ; oil palm fiber ; ABS ; rheology ; 4D printing ; material programming ; digital fabrication ; shape-memory polymers ; PPS ; carbon nanotubes ; thermal analysis ; electrical properties ; rheological properties ; resin transfer molding ; non-crimp fabrics ; consolidation ; ultra-high molecular weight component ; rheological property ; crystallization behavior ; polyimide foam ; rigid closed-cell foam ; high temperature ; benzimidazole ; polyamide 12 ; carbon nanofiller ; carbon nanotube ; graphene nanoplatelet ; 3D printing ; thermal conductivity ; compound ; fluorinated aromatic polyimide ; low dielectric loss ; molecular chain orientation ; molecular dynamics simulation ; long-fiber-reinforced thermoplastic ; fiber length ; fiber orientation ; injection molding ; hollow composite tubes ; bending ; failure mechanisms ; in situ consolidation ; void content ; processing parameters ; thermosetting resins ; thermoplastics ; co-bonding ; interphase ; diffusion ; adhesion ; phosphorescent composites ; compatibilizer ; thermal and mechanical ; composite ; thermoplastic ; thermoforming ; simulation ; Taguchi ; DOE ; oil palm fiber composites ; 3D composites ; thermoset ; off-axis flexure behaviour ; on-axis flexure behaviour ; hybrid fibers ; hybrid composites ; vacuum assisted resin infusion (VARI) ; fracture toughness ; fractography ; reinforcements ; thermal properties ; biobased polymer composites ; polymer modification ; PBAT ; starch ; microcrystalline cellulose ; biodegradable ; polyethylene glycol ; poly(butylene adipate-co-terephthalate) ; supercritical CO2 ; foam ; thermoplastic matrix composites ; impregnation processes ; manufacturing ; fiber reinforced ; processing ; retrogradation ; extrusion ; co-plasticization ; isosorbide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint presents a collection of contributions on the application of high-performing computational strategies and enhanced theoretical formulations to solve a wide variety of linear or nonlinear problems in a multiphysical sense, together with different experimental studies.
    Keywords: nanotwin ; detwinning ; extreme hardness ; excellent stability ; electrospinning ; nanofibrous membrane ; geometric modeling ; uniaxial tensile ; buckling ; electromagnetic field ; nanobeam ; shifted chebyshev polynomial ; rayleigh-ritz method ; nanocomposites ; FG-CNTRC ; truncated cone ; critical combined loads ; multi-scale mechanics ; finite element analysis ; material testing ; cellulose nanofiber ; polymer composites ; tensile modulus ; cove-edges ; defects ; fracture ; graphene ; molecular dynamics ; strength ; recycling ; circular economy ; nanometric carbon-based ashes ; AJ®P ; non-piezoelectric polymers ; tactile sensors ; robotic gripper ; fluorinated epoxy resin ; fluorinated graphene oxide ; ordered filling ; elastic modulus ; glass transition temperature ; microscopic parameters ; surface bonding ; nanocone arrays ; molecular dynamics simulation ; axially functionally graded materials ; differential quadrature method ; flexural–torsional buckling ; nonlocal elasticity theory ; tapered I-beam ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book focuses on advanced techniques to reduce the impact of the transport sector and, more specifically, of Spark-Ignition (SI) Internal Combustion Engines (ICEs) on atmospheric air pollution and climate change. Hybrid vehicles represent the most suitable option for addressing these issues in the medium term, since hybridization allows us to overcome the major disadvantages of ICEs, electric units, and energy storage devices and merge their respective benefits. In this scenario, ICEs will remain the core component of automotive propulsion systems in the years to come. Of course, further efforts to improve the efficiency and reduce the pollutant and CO2 emissions of ICEs are necessary.
    Keywords: washcoat ; powder material bulk density ; coating ; backpressure ; PN filtration efficiency ; spark ignition engine ; combined method of power regulation ; fuel economy ; the idling mode ; switching off the cylinder group ; spark-ignition engine ; model predictive control ; electric pump ; engine thermal management ; Miller cycles ; early intake valve closing ; electro hydraulic valve train ; energy balance ; heat losses ; spark plug ; new design ; experimental analysis ; thermo-mechanical model ; Inconel 601 ; virtual engine calibration ; ultra-lean combustion ; hybrid vehicle ; 0D-1D engine modelling ; internal combustion engine ; combustion ; emission ; RANS simulation ; turbocharged gasoline engine ; port water injection ; predictive combustion model ; knock mitigation ; engine performance ; virtual test rig ; engine fan ; rotor blade ; electromagnetic scattering characteristic ; dynamic simulation ; grid transformation ; hybrid powertrain ; optimization strategy ; computational efficiency ; energy management ; biodiesel ; load ; heat loss ; cylinder pressure ; heat release rate ; python ; CFD ; cycle-to-cycle variations ; knock ; efficiency improvement ; CO2 emissions ; control ; adaptive strategy ; modeling ; transport ; engines ; diesel oil ; biocomponents ; environment ; sustainable development ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TR Transport technology and trades
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint aims to address the challenges modern-day buildings face in the context of high energy and resource consumption and climate change. One of the ways to address the issues is holistic design and operation of high-performance buildings in the area of energy efficiency, occupant health, and comfort. All this should be achieved through synergic interconnectedness between parameters such as the indoor–outdoor environment, sustainability, and resilience. Through different chapters, this reprint highlights the key areas, namely, the optimization of building design parameters, the impact of the use of modern-day phase-change materials, the adaptation of occupants and buildings to climate change, the mitigation of urban overheating by cool roofs, and reducing energy demand and CO2 emissions.
    Keywords: climate change ; bioclimatic design ; passive design ; energy efficiency ; overheating ; building resilience ; robustness ; shape factor ; building ; thermal envelope ; energy demand ; CO2 emissions ; white roofs ; cool roofs ; reflective material ; cost-benefit ; energy savings ; urban heat island ; thermal comfort ; indoor environmental quality ; educational buildings ; energy consumptions ; local discomfort ; building energy retrofitting ; phase change materials ; aerogel render ; heat stress risk ; emission ; lifecycle cost ; peak cooling load ; residential building ; building envelope ; multi-objective genetic algorithm ; TRNSYS ; climate zone ; multi-criteria decision making ; CRITIC ; TOPSIS ; capture devices ; variables ; field surveys ; thermal perceptions ; adaptive actions ; hostel dormitories ; composite climate of India ; reflective materials ; mitigation ; outdoor comfort ; visual comfort ; heat stress ; optimization ; skyscrapers ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: As we know, strokes are one of the world's leading causes of death, and the cruel aspect of a stroke is that it leaves people with severe functional disability and/or cognitive impairment. Strokes have a significant impact on economies worldwide, as it is estimated that about 10% of the male population and 8% of the female population are affected by them. Such people need personal help in their everyday life and must be materially supported by social services. With the advancement of medicine, artificial intelligence, and new technologies have been developing rapidly and are gradually applied in diseases of the nervous system, increasingly helping diagnosis, treatment, rehabilitation, and prognosis of disease.This Special Issue has collected the 14 papers on artificial intelligence and new technologies in strokes, including in the aspects of diagnosis, treatment, prognosis, rehabilitation, and nursing. We welcome your reading.
    Keywords: non-invasive brain stimulation ; stroke ; spasticity ; meta-analysis ; hemiplegia ; electromyographic bridge ; upper limb rehabilitation ; randomized controlled trial ; hypoxic ischemic encephalopathy ; disorders of consciousness ; metabolic connectivity ; positron emission tomography ; 18F-fluorodeoxyglucose ; hand function rehabilitation ; hand rehabilitation robot ; computer vision technology ; wearable devices ; sensors ; artificial intelligence ; brain–computer interface ; active rehabilitation training ; motor function ; brain function ; executive function ; postural control ; gait ; repetitive transcranial stimulation ; facial paralysis ; peripheral magnetic stimulation ; blood flows ; laser speckle ; stroke rehabilitation ; upper limb ; automated system ; motor function assessment ; Fugl-Meyer Assessment ; motor attempt (MA) ; EEG ; deep learning method ; overlapping time window ; facial expression recognition (FER) ; vision transformer (ViT) ; convolutional neural networks (CNNs) ; rehabilitation ; assessment ; upper extremity ; hand ; brain–computer interfaces ; motor task ; sensorimotor rhythm ; hand rehabilitation ; motor imagery ; virtual reality ; rTMS ; DTI ; immersive virtual reality ; post-stroke cognitive impairment ; aging ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This overview of the most recent advances in the field of SMA research and applications in civil engineering aims to help remove the knowledge barriers across disciplines and sheds considerable light on the opportunity to commercialize SMA products in the construction industry.
    Keywords: seismic analysis ; rocking pier ; shape memory alloy ; ECC material ; bridge engineering ; television transmission tower ; seismic excitation ; shape memory alloy damper ; parametric study ; vibration control ; shape memory alloys ; engineered cementitious composites ; composites materials ; self-recovery capacity ; bending behavior ; machine learning ; artificial neural networks ; superelastic ; parameter identification ; constitutive model ; thermodynamic parameters ; shape memory alloy (SMA) ; self-centering SMA brace ; loading rate ; initial strain ; energy dissipation coefficient ; self-centering ; beam-column joints ; seismic performance ; iron-based shape memory alloy (Fe-SMA) ; shape memory effect ; martensitic transformation ; prestressing ; low cycle fatigue ; seismic ; damping ; transmission tower ; wind excitation ; SMA damper ; energy response ; viscoelastic ; brace ; hybrid control ; seismic resilience ; self-centering rocking (SCR) piers ; seismic fragility ; resilience ; life-cycle loss ; ferrous shape memory alloys ; prestress ; recovery stress ; relaxation ; thermomechanical behavior ; fatigue ; active materials ; low-cost SMAs ; civil engineering applications ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials::TNKX Conservation of buildings and building materials
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Hyperbaric oxygen is a known therapeutic agent, and treatments using this agent remain a matter of discussion and research. This Special Issue collection will add new knowledge and also offer some not so usual approaches to foster contemporary understanding and potential benefit for patients and scholars.
    Keywords: hyperbaric oxygen therapy (HBOT) ; Hyperoxia ; wound healing ; antimicrobial properties ; Coronavirus Disease-19 (COVID-19) ; critical flicker fusion frequency ; threshold of flicker fusion ; neuropsychology ; diving and hyperbaric medicine ; minimal hepatic encephalopathy ; diabetes ; hyperbaric oxygen therapy ; glycaemia ; oxygen ; hyperbaric oxygen ; epigenetics ; normobaric oxygen paradox ; hyperoxic-hypoxic paradox ; frostbite ; classification ; cold disease ; prognosis ; amputation ; medical outcome ; atmosphere exposure chambers ; diving physiology ; decompression ; periodontal disease ; oral health index ; dental mobility ; periodontal pockets depth ; subfoveal choroidal thickness ; intraocular pressure ; central corneal thickness ; central serous chorioretinopathy ; flow-mediated dilation ; arterial stiffness ; endothelial dysfunction ; n/a ; FMD ; underwater ; hyperbaric ; commercial diver ; off-shore energy operation ; human ; adverse effects ; autonomic nervous system ; lung ultrasound ; mixed gas diving ; pulmonary function ; technical diving ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This is a reprint of a Special Issue of Energies, titled "Condition Monitoring and Failure Prevention of Electric Machines". This Special Issue primarily focused on the issues related to the advanced monitoring, diagnosis, and prevention of typical and complex faults in all kinds of electric machines. Four guest editors, namely Prof. Yu-Ling He (Department of Mechanical Engineering, North China Electric Power University, China), Prof. David Gerada (PEMC group, University of Nottingham, UK), Prof. Conggan Ma (School of Automotive Engineering, Harbin Institute of Technology, China), and Prof. Haisen Zhao (School of Electrical and Electronics Engineering, North China Electric Power University, China), worked together on this Special Issue.
    Keywords: synchronous generator ; dynamic rotor interturn short circuit (DRISC) ; electromagnetic torque (EMT) ; magneto-motive force (MMF) ; harmonic component ; line start permanent magnet assisted synchronous reluctance motor ; power factor curve valley ; efficiency ; whole load region ; in situ efficiency ; induction motors ; quantum particle swarm optimization ; trust region algorithm ; QPSO-TRA ; rotor slot harmonics frequencies ; linear motor feeding system ; lack of abnormal samples ; deep neural network ; anomaly detection ; semi-supervised anomaly detection generative adversarial network (GANomaly) ; long short-term memory (LSTM) network ; doubly fed induction generator (DFIG) ; radial static air-gap eccentricity (RSAGE) ; radial dynamic air-gap eccentricity (RDAGE) ; radial hybrid air-gap eccentricity (RHAGE) ; circulating current inside parallel branches (CCPB) ; hydro-turbine modeling ; dynamic modeling ; transient processes ; hydropower ; hydropower plants ; mathematical modeling ; water flow inertia ; artificial neural networks ; contrast estimation ; fault diagnosis ; short-circuited turns ; transformer fault ; vibroacoustic signals ; condition monitoring ; demagnetization ; direct torque control ; eccentricity ; field oriented control ; high resistance connection ; turn-to-turn short circuit ; permanent magnet synchronous machine ; supervised classification ; power supply systems ; unbalanced load flows ; unbalanced load ; parameter identification ; hybrid surrogate model ; performance optimization ; Kriging ; RBF ; genetic algorithm ; pulse-jet cleaning ; field-oriented control ; symmetrical components ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration.
    Keywords: bone ; collagen type I ; alginate ; conditioned medium ; viability ; MSC ; osteogenesis ; pulsed electromagnetic field ; osteogenic factors ; wool keratin scaffolds ; bone tissue engineering ; biocompatibility ; biomaterials ; bone augmentation ; bone conduction ; bone grafting ; calcium hydroxyapatite ; tissue regeneration ; dental implants ; osseointegration ; osteoporosis ; zoledronate ; animal model ; titanium membrane ; titanium foil ; occlusive titanium barrier ; guided bone regeneration ; osteoporotic condition ; xenograft ; bone regeneration ; titanium implants ; additive manufacturing ; reused powder ; unit cell topology ; tissue engineering ; mechanical properties ; stem cells ; surface functionalization ; titanium ; protein adsorption ; surface modifications ; cell interactions ; collagen hydrogel ; cell delivery ; olfactory ectomesenchyme stem cells ; bioactive glasses ; alkali-free ; sol–gel ; bone remodeling ; bone disorders ; biomechanics ; scaffolds ; microenvironment ; 3D bioprinting ; computational modeling ; bone implant ; bone defects ; chitosan ; degree of deacetylation ; bone formation ; X-ray micro CT ; histology ; sheep tibia ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Water resource management includes the consideration of all disciplines of hydrology and water sources. Water supplies are allocated and diverted to cover the water needs of a range of agricultural, municipal, industrial, hydro-electrical, and ecological water uses. These water uses are, usually, very competitive, as the available water resources are limited and it is not possible to cover the total water needs in a basin, requiring the setting of water use priorities to best serve societal and ecological needs. To manage the water resources and waterworks may, sometimes, lead to confrontational deliberations and negotiations. As a result, water resource management is one of the world’s greatest challenges due to competition for limited resources, regional disparities in water supply and affluence, mounting global water demand, aquifer depletion, and pollution- and climate-change-induced water stress. Proper policy and governance for sustainable water resource management is essential and require new fresh ideas, innovation, and international cooperation. This book includes seven papers by invited renowned researchers and engineers to cover issues of water resource management, governance, and policy. These issues include the following topics: Integrated water resource management; Water resource systems and water availability; National and international water policy, institutional arrangements, and water law; Water conflict resolution, public participation, and decision making; Water resource management, policy and governance in socially and environmentally sensitive areas and regions.
    Keywords: water allocation ; planning ; river/reservoir systems ; water availability modeling ; global change ; integrated assessment modelling ; system dynamics simulation ; water resources management ; water supply ; climate change ; earth system ; feedback ; conflicts ; environmental flows ; small-scale hydropower projects ; institutional change ; nestedness ; governance mode ; legal pluralism ; mulberry-dyke-fish pond ecosystem ; spatial evolution analysis ; remote sensing ; Guangdong–Hong Kong–Macao Greater Bay Area ; prolonged drought ; scarcity ; indicators ; transboundary river basins ; Iberian Peninsula ; climate crisis ; water adaptation ; Greece ; Koronia lake ; sustainability ; Mygdonia Basin ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This reprint focuses on the current progress in sports medicine, with a specific interest in surgery, exercise therapy, and multi-disciplinary research. With the advancement of society, more attention is paid to the quality of life, which emphasizes the importance of sports and exercise. Correspondingly, there is a great need for sports medicine. This issue collected novel findings on sports medicine in surgery, conservative therapy, and the application of exercise training in other disorders
    Keywords: shoulder ; rotator cuff ; allografts ; demineralized bone matrix ; biologics ; diabetes mellitus ; aerobic training ; resistance training ; vascular function ; meta-analysis ; femoroacetabular impingement ; hip arthroscopy ; longitudinal capsulotomy ; femoroplasty ; labrum repair ; degenerative lumbar diseases ; albumin-to-alkaline phosphatase ratio ; spinal fusion rate ; prognostic marker ; arterial hypertension ; exercise hypertension ; blood pressure ; exercise testing ; sports injuries ; machine learning ; injury prediction ; sports monitorization ; elite football ; performance ; systemic inflammation ; physical endurance ; physical fitness ; maximal aerobic capacity ; gingivitis ; cardiac rehabilitation ; exercise therapy ; balance exercises ; cardiovascular diseases ; ACLR ; hamstring tendon with preserved tibial insertion ; MRI ; T2 ; cartilage volume ; gait retraining ; running-related injuries ; kinetics ; kinematics ; rehabilitation ; rotator cuff tear ; rotator cuff repair ; bone quality ; osteopenia ; osteoporosis ; anchor pullout ; pullout strength ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Novel Anticancer Strategies (Volume II) reviews important findings and updates within the cancer therapy field of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key Features:Nanoparticle-based drug delivery in cancer therapy;Nanoerythrosomes;Cancer immunotherapy;Therapeutic vaccines;Oncogenic and tumor suppressive components of the cell cycle;Antimitotics in cancer clinical trials;Multifunctional enzymes as anti-cancer drug targets;Targeting undruggable proteins and non-coding RNAs;Cell-penetrating peptides;Repurposed cancer drugs in clinical trials;Circulating tumour cells.
    Keywords: Breast cancer treatment ; Photodynamic therapy ; Inorganic nanoparticles ; Active targeting ; cathepsins ; BAX ; MOMP ; ubiquitination ; apoptosis ; chemotherapy ; cancer ; nanoerythrosome ; nanoerythrocyte ; nanovesicles ; biomimetic ; cancer therapy ; diagnostics ; imaging agents ; cell cycle ; cyclin-dependent kinase ; p16 ; p21 ; p27 ; breast cancer ; prognosis ; drug delivery ; HL60 ; leukemia ; prodrug ; resistance ; retinoic acid ; vitamin K ; drug repurposing ; COVID-19 ; pandemic ; vaccination ; multi-drug resistance ; enhanced permeation and retention effect ; nanotherapeutics ; cancer theranostic ; clinical translation ; cell-penetrating peptides ; protein transduction domains ; tumor imaging ; targeted therapies ; dog ; comparative oncology ; molecular targets ; spheroids ; tumoroids ; hydrogel ; collagen ; agarose ; mammary spheroids ; tissue engineering ; cisplatin ; melanoma ; melanin nanoparticles ; cytotoxicity ; laser medical applications ; hyperthermia ; antimitotics ; mitotic slippage ; spindle assembly checkpoint ; clinical trials ; TRAIL ; cancer stem cells ; TRAIL resistance ; angiogenesis ; on-demand drug delivery systems ; electrospun nanofibers ; poly (N-isopropylacrylamide) ; gold nanorods ; paclitaxel ; β-Cyclodextrin ; SPIONs ; metallodrugs ; RAPTA derivatives ; phosphino-amine ligands ; CTCs ; NSCLCs ; metastasis suppression ; curcumin ; flavonoids ; TNBC ; immunotherapy ; immune checkpoint ; nanocarrier ; combinational immunotherapy ; lung cancer ; miRNA ; oncomiRs ; photodynamic therapy PDT ; porphyrin ; iron oxide nanoparticles ; mesoporous silica nanoparticles ; antibody functionalization ; targeted drug delivery systems ; molecular-targeted therapies ; multifunctional enzymes ; HCC ; CHRNA5 ; metastasis ; stemness property ; sorafenib sensitivity ; neoantigens ; vaccine ; Patched ; chemotherapy resistance ; metastases ; persistent cells ; adrenocortical carcinoma ; BUB3 ; mitosis ; senescence ; anticancer target ; boron neutron capture therapy ; 4-borono-l-phenylalanine ; drug discovery ; solubility ; mebendazole ; polymer ; HPMA ; controlled drug release ; PLK1 ; BI2536 ; Navitoclax ; slippage ; PD-1 ; gemcitabine ; new anti-cancer drugs ; precision medicine ; undruggable targets ; non-coding RNAs ; oligonucleotide therapeutics ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint delves deep into the principles, practices, and possibilities of the sustainable circular bioeconomy. Within these pages, you will find a wealth of knowledge and insights contributed by experts, researchers, and practitioners who have dedicated their lives to advancing the boundaries of sustainability. Each chapter of this reprint is carefully crafted to provide a holistic view of the subject, covering a wide range of topics, including renewable energy, waste management, food–energy–water nexus, digital innovation in sustainability, aquaculture, agriculture, biotechnology, and more.
    Keywords: bioeconomy ; digitalization ; platform-based bioeconomy ; smart and sustainable development ; governance ; oyster mushroom ; agro-industry ; wastes ; productivity ; quality ; DDGS ; alternative diet for swine ; byproduct diet ; global warming potential ; standard corn–soybean meal ; biomass ; self-sufficiency ; material flow ; import dependency ; Kolleru Lake ; land use ; aquafarming ; fishponds ; illegal fishponds ; food–water–soil–ecosystem nexus ; Google Earth Engine ; freshwater ecosystem web model ; India’s largest freshwater lake ; NTFP ; NWFP ; Kashmir Himalayas ; livelihood ; income inequality ; Lorenz curve ; Gini coefficient ; aqueous two-phase systems (ATPS) ; liquid–liquid extraction (LLE) ; pressurized hot water extraction (PHWE) ; solid–liquid extraction (SLE) ; natural products ; cocoa bean shell (CBS) ; precipitation ; total phenolic content (TPC) ; land expansion ; biofuels ; Green GDP ; computable general equilibrium ; life cycle impact assessment ; Water-Energy-Food nexus ; excellence models ; agro-industrial companies ; decision-support tool ; sustainable development ; innovative solutions ; new business ; horizon scanning ; Phoenix dactylifera L. ; date palm drying ; solar dryer ; PV winnower ; economic evaluation ; hybrid solar dryer ; apparel ; clothing industry ; apparel consumer behavior ; circular economy lens ; mindful clothing consumption ; sustainable fashion ; green fashion ; circular textiles ; sustainable garments ; green consumer ; life cycle thinking of textiles ; responsible consumption ; bioeconomy strategy ; policy coherence ; policy framework ; strategic development ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Almost all fields of dentistry are closely related to newly developed materials, and all clinical improvements often follow, or, in any case, go hand in hand with the creation and the development of innovative and higher performing materials, instruments, and equipment. Thanks to contemporary applications of dental materials, the effectiveness of clinical dentistry has made remarkable advances. In recent years, thanks to digital technology and the frenetic development of the dental industry, new materials have been developed and proposed in many fields of dentistry: prosthesis, restorative dentistry, endodontics, implantology, and orthodontics. Unfortunately, as often happens, this productive challenge is not always accompanied by valid scientific research, and consequently the clinician finds new materials at their disposal that are not necessarily better than the old. Further studies are needed to gain relevant evidence for all recently introduced dental materials. This reprint includes research articles, clinical studies, review articles, and case reports focused on the latest advances and prospects of dental materials concerning all fields of dentistry.
    Keywords: MIH ; hypersensitivity ; enamel infiltration ; hypomineralization ; marginal adaptation ; fixed partial denture ; dental technology ; cobalt–chromium alloys ; scanning electron microscopy ; titanium ; dental implants ; hydrophilic ; hydrocarbon ; biological ageing ; UV photofunctionalization ; alveolar bone defects ; guided bone regeneration ; titanium meshes ; customized titanium meshes ; laser melting process ; electron beam melting ; composite restoration ; microleakage ; oblique layering technique ; horizontal layering technique ; composite ; fluorescence ; de-bonding ; residuals ; enamel damage ; orthodontics ; radiolucent sign ; OPG ; CBCT ; third molar ; oral surgery ; periapical sign ; biofilm ; bone healing capacity ; infected gutta-percha ; rat calvarium ; zirconia ; airborne particle abrasion ; femtosecond laser ; flexural strength ; surface roughness ; bond strength ; brackets ; dry ; wet and moistened enamel ; adhesion ; calcium phosphate ; radiation-induced center ; hyperfine interaction ; EDNMR ; ESEEM ; ENDOR ; biomaterial ; bone regeneration ; bone substitute ; dental implant ; octacalcium phosphate ; TiN ion plating ; metal allergy ; orthodontic wire ; micro-implants ; success rate ; insertion ; loading ; biocompatibility ; compliance ; dental material ; restorative material ; glass ionomer ; resin-modified glass ionomer ; pH ; acidity ; oral environment ; dental filling ; dental restoration ; apical negative pressure irrigation ; calcium hydroxide removal ; intracanal medicament ; mechanical activation ; ultrasonic activation ; osseoincorporation ; osseointegration ; trabecular metal ; guided tissue regeneration ; barrier membranes ; allergology ; demineralized dentin matrix ; human demineralized dentin matrix ; human ; bone graft ; FT-MIR ; SEM ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Semiconductor lasers are carriers of both energy for industry and information for optical communications. The recent progress in research on semiconductor lasers has offered new perspectives regarding both their material growth and structural design. Most of the papers are review papers that briefly overview different types of semiconductors. Some of the papers include the newest research results. We all hope that this Special Issue can shed light on recent advances in the field of semiconductor lasers and their applications so that most of the readers’ concerns about semiconductor lasers can be addressed and a conversation can be initiated.
    Keywords: silicon substrate ; narrow linewidth ; widely tunable ; external cavity ; high-power semiconductor laser ; failure mechanisms ; accelerated aging test ; failure analysis techniques ; FSBDG ; FBG ; silicon-based waveguide ; confocal F-P cavity ; DFB laser array ; multi-wavelength ; series and parallel ; optical communication ; photonic integrated circuits ; selective area epitaxy ; MOCVD ; semiconductor laser ; quantum dot ; heteroepitaxy ; EML ; multi-wavelength laser arrays ; optical crystals ; 1.3 μm laser ; passively Q-switched laser ; all-solid-state-laser ; saturable absorber ; perovskite lasers ; perovskite semiconductors ; solution process ; vertical external cavity surface-emitting laser ; laser resonator ; wireless power charging ; detection ; ECQCL ; QCL ; tunable ; diode laser array ; external cavity feedback ; volume Bragg grating ; tuning central wavelength ; diamond ; thermal effect ; high power ; thermal-structural coupling model ; temperature effects ; carrier confinement ; internal quantum efficiency ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Childhood cancer or pediatric cancer is one of the leading causes of death among children. Treatment strategies for pediatric cancers include chemotherapy, surgery, radiation, and stem cell transplantation. These therapeutic regimens are well known to develop highly toxic and long-lasting side-effects including secondary cancers in the future lifespan of pediatric patients. Despite these intensive therapeutic regimens, cancer may still relapse as refractory and metastatic cancer. Therefore, further understanding the causes of different pediatric cancers, mechanisms of drug-resistance, and causes of relapse and metastasis is required for developing and advancing less toxic and more effective therapeutic strategies for pediatric cancers. Recent advancements in immunotherapies and targeted therapeutic approaches using pharmacological inhibitors are one step in this direction.In this Special Issue of Cancers, authors contributed original research and review articles focusing on different aspects of pediatric cancer development, causes, maintenance, and therapeutic strategies. The collected articles in this Special Issue will further enhance our knowledge and understanding of pediatric cancers and drive the development of novel therapeutic strategies.
    Keywords: infections ; cancer ; children ; bacteremia ; pneumonia ; sarcoma ; solid tumor ; outcome ; KI67 ; EZRIN ; 18F-FDG PET/CT ; random forest ; radiogenomics ; chemotherapy response ; metastasis ; serine-threonine kinase receptor-associated protein ; neuroblastoma ; CRISPR-Cas9 ; metronomic chemotherapy ; maintenance therapy ; high-risk ; Ewing sarcoma ; RNA-binding proteins ; regulation network ; prognosis prediction ; risk model ; melanotic neuroectodermal tumor of infancy ; inoperable ; metastatic ; recurrent ; chemotherapy ; adjuvant ; neoadjuvant ; systemic treatment ; childhood malignant bone tumors ; survivorship ; late effects ; somatic disease ; cohort study ; rhabdomyosarcoma ; targeted therapies ; cell surface proteomics ; B7-H3 ; stress ; allostasis ; stress regulatory pathways ; stress dysregulation ; stress reactivity ; early life stress ; childhood cancer ; cytotoxic cancer treatment ; interventions ; ependymoma ; risk stratification ; molecular group ; prognosis ; nephroblastoma ; clinical malformations ; cancer predisposition syndromes ; tumor surveillance ; n/a ; DSRCT ; EWSR1-WT1 ; preclinical model ; in vitro model ; pediatric cancer ; pediatric ; brain ; tumor ; medulloblastoma ; glioma ; natural products ; drug discovery ; fungal secondary metabolites ; soil microbes ; RH30 ; RD ; EZH2 ; epigenetic ; EPZ005687 ; DZNep ; AdOx ; malignant rhabdoid tumor ; hepatoblastoma ; small cell undifferentiated (SCUD) hepatoblastoma ; SMARCB1 ; INI1 ; pediatric liver tumors ; drug repurposing ; PI3K pathway ; epigenetics ; Fimepinostat ; LPAR1 ; LPA ; tumor metastasis ; bioinformatics analysis ; ulixertinib ; ERK inhibition ; combination therapy ; c-Myc/N-Myc ; cell differentiation ; ATRA ; SOX4 ; diffuse intrinsic pontine glioma ; immunotherapy ; immune microenvironment ; immune checkpoint inhibitor ; vaccine ; oncolytic virus ; myeloid sarcoma ; chloroma ; acute myeloid leukemia ; pediatric cancers ; VIPN ; DIC ; MDR ; drug transporters ; childhood acute leukemia ; early complication ; hyperleukocytosis ; risk factor ; survival outcome ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The researchers involved in this reprint will continue their studies to improve the existent dental biomaterials in order to achieve optimal dental treatment with biocompatible, bioactive, and stable properties. As the Guest Editors, we sincerely value and thank the reviewers for their insightful comments and the support of the team at Bioengineering. Finally, we express our gratitude to all contributing authors for their valuable research. Altogether, the 16 research papers/reviews in this Special Issue entitled "Recent Advances in Biomaterials and Dental Disease" reflect the importance of in vitro and in vivo studies for improving the efficacy of using biomaterials in dental treatment.
    Keywords: adhesion ; bonding ; dental porcelain ; glass ceramics ; orthodontic bracket ; shear strength ; aligner ; cytotoxicity ; estrogenicity ; invisalign ; monomer ; retainer ; 3D resin ; endodontic sealer ; polyphenols ; resveratrol ; pyrogallol ; biological activity ; piezoelectric surgery ; endodonticsurgery ; crack formation ; ultrasonic tip ; retropreparation ; antibacterial effect ; dental impressions ; disinfectant agents ; disinfection ; oral bacteria ; implant periapical lesion ; implant failure ; peri-implantitis ; endodontic surgery ; complication ; retreatment procedure ; filling materials removal ; revision system ; sonic activation ; oval-shaped canal ; decontamination ; lithium disilicate ; resin ; saliva ; shear bond strength ; crowns ; fixed prosthodontics ; resin composite ; survival ; bond strength ; contact angle ; dentin ; desensitizers ; resin cements ; 3D printing ; digital light processing ; interim crown ; in vivo study ; wear ; endodontists ; general practicing dentists ; root canal treatment ; quality ; undergraduate students ; traumatic dental injury ; tooth fracture ; adhesive reattachment ; pulp ; regeneration ; revitalization ; transplant ; root ; maxillary premolars ; upper premolars ; canal ; root canal anomalies ; anatomical variations ; root morphology ; coneless ; MEA technique ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Transportation is one of the most crucial aspects across the world, supporting the daily life of human beings and the sustainable development of the whole of society. Generally, meteorology causes various impacts on transportation operation, safety and efficiency. In the context of global warming, increasing numbers of extreme weather and climate events (such as fog, icy roads, and extreme winds) have been detected worldwide and are expected to occur more frequently in the future. Meanwhile, extreme events, such as dense fog, rainstorm, and blizzard, tend to damage transportation and traffic facilities (such as express ways, port, airport, and high-speed railway) and induce serious traffic blocks and accidents. In recent decades, concentrated and continuous efforts have been made to carry out meteorological analyses regardless of urban traffic or transportation conditions, including those of highways, shipping, aviation, etc. A number of methods and techniques have been intensively developed to promote the qualities of both observations and forecasts. More recently, state-of-the-art machine learning frameworks have also been widely introduced into studies regarding transportation meteorology and many other fields.
    Keywords: transportation meteorology ; pavement temperature prediction ; deep learning ; BiLSTM ; attention mechanisms ; winter icing ; air pollution ; traffic vitality ; built environment ; spatial correlation ; spatial lag model ; phone signaling data ; air quality ; behavioral habits ; activity density ; population distribution ; land use mix ; wind forecast ; error decomposition ; bias ; distribution ; sequence ; urban meteorology ; observation ; forecast ; early warning ; review ; China ; low-level wind shear ; ensemble learning classifiers ; Bayesian optimization ; SHapley Additive exPlanations ; wind shear ; go-around ; machine learning ; dynamic ensemble selection ; civil aviation safety ; pilot reports ; self-paced ensemble ; Shapley additive explanations ; climate change ; climatology ; sea ice ; marginal sea ; East Asia ; time-series modeling ; pavement temperature ; nowcasting ; variation characteristics ; forecast validation ; relative humidity ; microwave radiometer data ; total rainfall ; precipitation duration ; vertical distribution ; Beijing–Tianjin–Hebei region ; rail breakage ; frequency ; high-speed railway ; Siberian high ; teleconnection ; temperature ; Qinling mountains ; rainfall ; change characteristics ; geographical factors ; highways ; road blockage ; fuzzy analytic hierarchy process ; CRITIC weight assignment method ; road network vulnerability ; spatiotemporal distribution ; precipitation forecast ; ConvLSTM ; PredRNN ; expressway ; agglomerate fog ; risk level prediction of fog-related accidents ; meteorological conditions ; road hidden dangers ; traffic flow conditions ; visibility ; Yellow Sea and Bohai Sea ; observation data ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TR Transport technology and trades
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: This reprint focuses on recent advances in the clinical care of patients with acute and chronic coronary syndromes. We must accumulate novel scientific and clinical knowledge in this field to develop seamless treatments and preventive strategies for this patient population. Furthermore, accumulated data have implicated that there are some residual risk factors for coronary syndromes, and the clinical management of cardiovascular/non-cardiovascular complications associated with coronary syndromes is also a critical concern. We hope that this reprint will facilitate the management of future patients with coronary syndromes; however, further research is still required. It is also our hope that this reprint will promote future research to enable a better understanding of the clinical practice of coronary syndromes.
    Keywords: statin ; myocardial infarction ; renal function ; coronary CT angiography ; subtraction ; fractional flow reserve ; coronary artery disease ; Agatston score ; uric acid ; endothelial function ; ischemic heart disease ; ischemia with no obstructive coronary artery disease ; angioplasty ; drug-eluting stents ; non-ST-elevation myocardial infarction ; multivessel disease ; acute coronary syndrome ; chronic coronary syndrome ; xanthine oxidoreductase ; coronary artery spasm ; gender differences ; vasospastic angina ; microvascular spasm ; microvascular vasodilatory function ; high coronary thrombus burden ; tissue plasminogen activator ; catheter-directed thrombolysis ; olmesartan ; amlodipine ; rosuvastatin ; single pill combination ; phase III clinical trial ; computed tomography ; computed tomography perfusion ; myocardial perfusion abnormality ; aspirin ; clopidogrel ; prasugrel ; P2Y12 inhibitor ; bleeding ; nitrate ; vasodilator ; biomarker ; mortality ; risk-score model ; n/a ; NGAL ; contrast-induced acute kidney injury ; percutaneous coronary intervention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: There has been significant growth in branches of industry directly related to new materials, such as metals, polymers, and composite materials. Considering the increase in material costs, it has become exceedingly important to produce lightweight constructions through the use of certified materials with appropriate mechanical properties. Many composite materials, especially in building engineering, are characterized by the use of waste materials, allowing them to meet environmental demands and often also positively affecting the performance (as well as mechanical) properties of the whole construction. A similar phenomenon has been noticed in polymers and metals, with the “ecologically friendly” factor having increasing influence in such materials. The main aim of our Special Issue was to gather novel research results concerning different materials available for all important industries—building engineering, the heavy industry, automotive, aerospace, and medicine. Such a general title has been proposed to also include different manufacturing technologies using various materials—conventional (milling, casting, forming, and turning) and novel (hybrid and additive manufacturing).
    Keywords: additive manufacturing ; powder bed fusion ; 316L stainless steel ; ultrasonic atomization ; gas atomization ; three-point bending ; polyamide-based composites ; fused filament fabrication ; concrete additives ; concrete fibers ; concrete strength tests ; threshold effect ; flake graphene ; graphene oxide ; reduced graphene oxide ; lubricants ; grease ; fatigue life prediction ; CuZn37 brass ; machine learning ; IPCs ; ceramic preform ; ceramic–elastomer composite ; silane coupling agent ; hot isostatic pressing (HIP) ; wettability ; mechanical properties ; mechanical engineering ; laser powder bed fusion ; 21 NiCrMo2 steel ; process parameters ; post-heat treatment ; torsional strength ; cellular structures ; 20MnCr5 Steel ; cement–glass composite bricks ; digital image correlation analysis ; material extrusion ; PET-G ; waste disposal ; hybrid additive manufacturing ; lattice structures ; hot isostatic pressing ; fatigue behaviour ; polymer–straw boards ; thermoplastic polymers ; annual plants ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint is based on “Antimicrobial resistance and anti-biofilms” in the journal Antibiotics since November of 2020. This reprint has one editorial article, eight research articles, one review article, and one case report article, covering a time period of 15 months from December of 2021 to February of 2023. Containing three major sub-topics in this reprint, four manuscripts regarding the prevalence of resistant microbes, the emergence and evolution of resistance, and the molecular investigation of resistance mechanisms fall into the first sub-topic as “Antimicrobial resistance in microorganisms: epidemiology and molecular mechanism”; three manuscripts fall into the second sub-topic as “New antibiofilm strategy against fungal and/or bacterial biofilms”; and three manuscripts regarding the production and characteristics of these functional material encapsulated/ delivered natural compounds, in vitro and in vivo antimicrobial and antivirulent effects, and their potential applications, such as in food and medicine, fall into the third sub-topic as “Influence of Functional Material-Based Encapsulation/Delivery on the Antimicrobial and Antivirulent Effects of Natural Compounds”. Articles contained in this reprint have provided comprehensive knowledge and insight in understanding of antimicrobial resistance epidemiology and molecular mechanism and new antibiofilm strategies.
    Keywords: carbapenem-resistant Enterobacteriaceae ; metallo-β-lactamases ; NDM producers ; complicated urinary tract infections ; outcomes ; costs ; burden of illness ; Medicare ; Serratia marcescens ; multidrug resistance ; mcr-9 ; blaIMP-26 ; megaplasmids IMP-26 ; evolutionary pathway ; Canarium patentinervium Miq. ; antibiofilm activity ; AcrAB-TolC efflux pump ; molecular docking ; Autodock Vina ; Staphylococcus aureus ; persisters ; biofilm ; antimicrobial activity ; drug combination ; Ralstonia mannitolilytica ; chronic obstructive pulmonary disease (COPD) ; catheter-related bloodstream infection (CRBSI) ; commensal ; pathogen ; chitosan ; nanoparticle ; antibiofilm ; cinnamaldehyde ; invasive plants ; natural products ; molecular networking ; Candida albicans ; betulinic acid ; biofilms ; extracellular matrix ; quorum sensing ; antibiotic resistance ; Streptococcus mutans ; dental caries ; Casearia sylvestris ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Coal is an important natural resource. Improving the safety levels of the coal mining process while ensuring that coal production is at an acceptable level are problems to which we must attribute great importance. This reprint focuses on the safety of coal mine production, including the latest work from leading researchers. It discusses and studies the progress of research on safety in theory, experiments and simulation. The content covers the safety of coal mine-related fields, including mine ventilation, fire and explosion prevention, gas drainage, coal dust prevention, safety equipment, and other aspects of safety technology research. Despite the interdisciplinary nature of the different studies, the common theme of security is closely linked to the different studies in this period.
    Keywords: coal mining ; process safety ; disaster prevention and control ; sustainable mining ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTU Mining technology and engineering
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This essential collection, edited by Dr. Zeheng Wang and Dr. Jing-Kai Huang, unveils the latest advancements in semiconductor technology that are considered to be the cornerstone of the modern digital era. Spanning cutting-edge research in semiconductor materials, devices, and systems, this reprint is an indispensable guide through the innovative realms of microelectronics and nanotechnology.Dive into expert discussions on device architectures, from high-electron-mobility transistors to innovative designs resistant to extreme conditions. Explore the frontiers of material science and fabrication techniques, witnessing groundbreaking methods that enhance device performance and reliability. Uncover the evolving landscape of energy efficiency and power management, crucial for next-generation telecommunications and electric vehicles. Lastly, immerse yourself in the dynamic world of optoelectronics, where advancements in light-based technologies are redefining possibilities.Bringing together pioneering research papers, this volume is not just an academic resource but a beacon for industry professionals and scholars alike, pointing the way to the future of semiconductor technology.
    Keywords: derating ; DC–DC converter ; eGaN ; PoL ; conductive polymer tantalum chip capacitor ; reliability ; MTBF ; quartz flexible accelerometer ; electric field coupling noise ; lock-in amplifier circuit ; AlGaN/GaN ; high-electron-mobility transistor ; passivation ; HfO2 ; power clamp circuit ; ESD ; HBM ; false trigger ; bulk electron accumulation (BEA) ; extended superjunction trench gate ; extended drain (ED) ; BV and Ron,sp ; fluorides ; diamond ; ultrashort-pulse laser ; direct laser inscription ; photoluminescent microbits ; vacancy clusters ; Micro-LED ; metasurface ; light extraction efficiency ; angular deflection ; polarization ; a-IGZO ; magnetron sputtering ; thin-film transistors ; oxygen vacancy ; oxygen flow rate ; band-to-band tunneling (BTBT) ; linear energy transfer value (LET) ; single-particle irradiation effect ; anti-irradiation optimization ; GaN ; high electron mobility transistors ; nanochannel ; tri-gate ; dual-gate ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The increasing concern regarding environmental issues has led to the adoption of stringent regulations worldwide to facilitate the urgent move towards green mobility and sustainable transportation. In this regard, electrified powertrains are bound to replace conventional thermal engines to reduce greenhouse gases and pollutant emissions. The synergy between the internal combustion engine and the electric unit in hybrid electric vehicles (HEVs) significantly reduces fuel consumption and emissions while maintaining high vehicle performance and driving comfort. Moreover, unlike pure electric vehicles, the hybrid electric powertrain fulfills even the most demanding energetic requirements, ranging from light- and heavy-duty vehicles to agricultural machinery, vessels, and aircraft, thus becoming the optimal sustainable solution in the short term. Nonetheless, the full potential of HEVs can only be exploited using a multidisciplinary approach to design the mechanical and electrical equipment and implement the optimal energy management strategy. This Special Issue, “Frontiers in Hybrid Vehicles Powertrain”, provides a broad perspective on the current challenges and research trends of the hybrid electric powertrain collecting nine peer-reviewed papers dealing with the main mechanical, electrical, controls, and energetic issues of HEVs.
    Keywords: hybrid vehicle powertrain ; hybrid electric vehicle ; alternative propulsion system ; e-mobility ; electrified powertrain ; power-split hybrid ; parallel hybrid ; hybrid electric tractors ; hybrid electric air-ground vehicle ; mechanical power transmission ; electric continuously variable transmission ; multimode transmission ; power-split hybrid transmission ; compound split transmission ; planetary gear trains ; mechanical efficiency ; power-flow ; global efficiency ; energy management strategy ; control strategy ; torque allocation control logic ; model predictive control ; Pontryagin&rsquo ; s minimum principle ; drivability and emission trade-off ; emissions reduction ; pollutant emissions ; CO2 emission ; NOx emissions ; battery ageing ; battery lifetime ; battery temperature ; calibration optimization ; thermal management ; hydrogen ; floating PV system ; &nbsp ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This book contains research articles on the advances in the aetiology of idiopathic scoliosis (IS), the spinal growth related to the implementation of growth modulation for the surgical treatment of early-onset IS, the non-surgical treatment of IS using Physiotheraputic Scoliosis Specific Exercises, and braces. Additionally, it focuses on issues related to surgical treatment, issues related to body posture and the quality of life of this sensitive group of people. The high quality of published papers in this Special Issue of the JCM serve these objectives.
    Keywords: idiopathic scoliosis ; health-related quality of life ; cultural adaptation ; Italian Spine Youth Quality of Life Questionnaire ; systematic review ; meta-analysis ; adolescent idiopathic scoliosis ; brace therapy ; brace concepts ; rigid brace ; night time brace ; ring apophysis ; maturation ; ossification ; fusion ; scoliosis ; nighttime orthotic treatment ; surgery ; quality of life ; paraspinal muscles ; cross-sectional area ; posterior approach ; computed tomography ; Italian spine youth quality of life questionnaire ; SRS-22 ; 22q11.2 deletion syndrome ; human model ; neuromuscular scoliosis ; radiography ; MRI ; curve morphology ; intraspinal anomaly ; body height ; pulmonary function test ; Cobb angle ; iTRAQ ; α-actin ; progressive ; differentially expressed proteins ; bracing ; physiotherapeutic scoliosis-specific exercise ; physical activity ; adherence ; spinal appearance ; shared decision-making ; personalised approach ; sclerostin ; osteocytes ; β-catenin ; Wnt signaling pathway ; scoliometer ; truncal asymmetry ; lateral spinal profile ; surface topography ; aetiology ; spinal deformities ; pathobiomechanics ; follow-up study ; Rett syndrome ; motor skills ; telerehabilitation ; physical therapy modalities ; home exercise program ; neurodynamic functions ; assessment ; pain ; treatment ; early onset scoliosis ; non-operative treatment ; body posture ; sports activity ; corrective exercises ; digital photography ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Advancements in medical imaging modalities have resulted in increasing the importance and demand of pediatric radiology. This reprint showcases various examples of advanced research in pediatric radiology and nuclear medicine. These include the use of medical imaging modalities such as computed tomography, general radiography, magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and ultrasound for diagnosis, as well as the performance of artificial intelligence (AI) in computer-aided detection and diagnosis in the pediatric population. The radiation dose issue of pediatric radiological examinations and emerging AI technology for dose reduction, as well as the use of three-dimensional printing based on medical images for pediatric surgical planning, healthcare professional education, and patient–clinician communication are also covered.
    Keywords: as low as reasonably achievable ; computed tomography ; convolutional neural network ; deep learning ; dose reduction ; generative adversarial network ; image processing ; machine learning ; medical imaging ; noise ; contrast-enhanced ultrasound ; head ultrasound ; brain death ; infants ; ancillary test ; child ; paediatric ; infant ; adolescent ; chest X-ray ; CXR ; chest radiography ; COVID-19 ; SARS-CoV-2 ; coronavirus ; biliary atresia ; ultrasonography ; diagnostic accuracy ; intraoperative cholangiography (IOC) ; diagnostic performance ; elastography ; three-dimensional printing ; congenital heart disease ; children ; model ; personalized medicine ; application ; confusion matrix ; disease identification ; image interpretation ; pneumonia ; artificial intelligence (AI) ; deep learning (DL) ; paediatric pneumonia ; chest radiograph ; computer-aided detection (CAD) ; cumulative ; radiation dose ; acute tonsillitis ; shear wave elastography ; stiffness ; pediatric ; magnetic resonance imaging ; infection ; neck ; emergency medicine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: A collection of articles published under the guidance of Assoc. Prof. Ph.D. Andrei Victor SANDU in the Special Issue "Obtaining and Characterization of New Materials, Volume II". The published articles under this Special Issue represent an excellent collection of research and review articles with cutting-edge results that promote sustainable development in the field of material engineering.
    Keywords: sheep wool thermal-insulating mattresses ; air quality ; water vapor permeability ; formaldehyde ; road concrete ; porosity ; (NMR) relaxometry ; freeze–thaw ; blast furnace slag ; bismuth ; intermetallic compound ; IMC thickness ; mechanical properties ; isothermal annealing ; geopolymer ; fly ash ; GGBFS ; compressive strength ; soil stabilization ; flowable composite resin ; hydrochloric acid ; surface roughness ; toothbrush ; thermal insulation ; recycling ; polyethylene terephthalate (PET) ; polyester (PES) ; natural fibres ; sheep wool ; chia seed oil ; fatty acids composition ; epoxidized vegetable oil ; epoxy equivalent weight ; shear thickening fluids ; aging ; lightfastness ; product degradation ; rigid pavement ; fly ash based geopolymer ; acid resistance ; selective laser sintering ; spread the powder quality ; parameter optimization ; DEM ; RSM ; NSGA-II ; 9K medium ; bioleaching ; Thiobacillus ferrooxidans ; pollution indices ; ecological risk ; polyoxyethylene alkyether sulphate foam ; blended geopolymer foam ; high temperature ; pre-foaming method ; hydroxyapatite ; lysine ; inorganic–organic composite ; glassy carbon electrode ; electrode coating ; electrochemical analysis ; Nile blue A ; multi-beam box girder bridge ; ESP strengthening ; field test ; load lateral transferring performance ; structural stiffness ; densified wood ; ammonia ; Brinell hardness ; Paulownia ; hornbeam ; geopolymers ; laser sintering ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint covers the latest developments in the field of eco-polymeric materials and natural polymer processing and utilization, highlighting cutting-edge research focusing on the processing of advanced polymers and their composites. It demonstrates that the field of eco-polymeric materials and natural polymers is still gaining increased attention. Innovative approaches as well as advanced applications of eco-polymeric materials and natural polymers in different fields, such as energy, environment, biomedical, biomaterial, and engineering, are reported in this reprint.
    Keywords: outdoor wood mats-based engineering composite ; wood-degrading fungi ; decay resistance ; durability ; nanohydrogels ; citral ; sustained-release ; mechanism ; bamboo ; anti-mould ; rosin modification ; round bamboo culm ; visual characteristics ; eye tracking ; surfactant ; urea-formaldehyde resin ; laminated bamboo veneer ; gluability ; wood–plastic composites ; heat transfer modeling ; sweet sorghum ; high-density polyethylene ; hot-pressing ; fibrovascular bundle ; salacca frond ; modified orientation board ; citric acid ; Aquilaria crassna wood ; natural rubber ; antifungal ; lignin ; proteins ; compression performance ; load–displacement curves ; digital image correlation (DIC) ; failure mode ; coupling agent ; interfacial bonding ; oriented strand–thermoplastic composites ; wood veneer–thermoplastic composites ; cross-laminated timber ; stability coefficient ; axial compression ; timber structures ; slenderness ratio ; Chinese pine wood ; pine needles ; bamboo culms ; bamboo leaves ; industrial hemp hurd ; CMC ; DS ; mechanical properties ; TG ; XRD ; FTIR ; chitosan ; tartaric acid ; nanocrystal ; self-assembly ; evaporation ; dehydration of crystallization ; biopolymers ; sustainability ; emergy accounting ; polyhydoxyalkanoates ; slaughterhouse residues ; poly(lactic acid) ; impact modifier ; polymer blends ; properties ; multilayered bamboo fiber ; topochemistry ; microscopic imaging ; gradient micromechanics ; core–shell structure ; hydrogel ; double load ; response surface ; acidic treatment ; colour ; mould-resistant ; starch ; Phyllostachys pubescens ; fibre ; lignification ; micro-morphological regions of cell wall ; syringyl lignin ; guaiacyl lignin ; visible-light spectrophotometry ; electrochemical method ; moisture content ; shrinkage strain ; wood water loss ; konjac glucomannan ; oxidized hyaluronic acid ; hydrogels ; tung oil ; thermal treatment ; color ; cellulose fibers ; adsorption ; Cr(VI) ; sulfhydryl-modified ; water resistance ; bamboo scrimber composite ; bonding interface ; polymer soil consolidation agent ; preparation conditions ; consolidated adhesive film ; compressive strength ; seedling transplanting ; chemical change ; thermal property ; delignification ; pyrolysis ; bamboo microstructure ; shear performance ; test methods ; moso bamboo ; fracture behavior ; shearing characteristics ; transparent bamboo ; optical properties ; functionalization and application ; glycerin ; sodium alginate ; tensile strength ; elongation at break ; poplar ; cell walls ; cross-linking modification ; wood properties ; egg white hydrogel ; dual cross-linking ; metal ions ; secondary structure ; biocompatibility ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 62
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: A full awareness of the role played by a healthy diet, as part of a healthy lifestyle, in countering or slowing-down chronic and degenerative diseases has strongly increased the interest in food bioactives and the return of ancient foods that are nowadays considered functional. In fact, these dietary substances, to which nutraceutical attributes are increasingly entrusted, could display disease-preventing effects on animals and humans. In this context, polyphenols, which are widespread and mostly copious in dietary plant sources, have gained a lot of attention thanks to their potential ability to halt or reverse oxidative stress-related diseases. Indeed, food could contain, beyond health-promoting compounds, toxicants which are naturally occurring or process-induced dietary compounds with adverse effects on human health. The presence and abundance of bioactives are strictly related to their food source. Edible plant components largely contain beneficial secondary metabolites, but understanding them fully is still an important challenge as complex biotic and abiotic interactions are involved in their biosynthesis. Analytical methods, which are increasingly powerful, could enhance our knowledge of food bioactives, whereas the deep investigation of their bioactivity and bioavailability could make them particularly useful.
    Keywords: Urtica dioica ; natural products bioactivity ; food bioactives ; nutraceuticals ; cancer therapy ; breast cancer ; Aloe vera ; Aloe vera polysaccharides ; in vitro fermentation ; SCFAs ; antioxidant capacity ; food waste recovery ; grape leaves ; UHPLC-HR-MS/MS analysis ; flavonol glycuronides recovery ; linoleic acid peroxidation products ; hexane ; gastric cells ; metabolomics ; cDNA microarray ; avocado ; LC/MS ; fat-soluble vitamins ; carotenoids ; Cannabis sativa L. ; phenylamides ; lignanamides ; hemp seeds ; high resolution tandem mass spectrometry ; U-87 glioblastoma cells ; cytotoxicity ; Pistacia vera ; antioxidant ; quality ; tocopherol ; FTIR ; discriminant analysis ; pistacia (Pistacia vera) hulls ; anticancer ; bacterial resistance ; efflux pumps ; terpenoids ; thymol ; carvacrol ; Rosmarinus officinalis L. ; fresh young shoots tincture ; polyphenols ; terpenes ; hepatoprotective ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The Special Issue "Fatigue and Fracture of Metals and Alloys: Numerical and Experimental Study" includes 19 articles covering problems in fatigue and fracture mechanics from different parts of the scientific world. The issue includes articles presenting theoretical, numerical, statistical and experimental approaches to fatigue life estimation. The influence of technological processes, state of stress, or the environment on steel and aluminum alloys is presented. The subjects of the articles of interest, as they present solutions to common practical problems in the industry.
    Keywords: &nbsp ; Fracture mechanics ; Fatigue ; Fatigue strength ; Constraint effect ; Digital image correlation&nbsp ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Gastrointestinal (GI) malignancies represent a diverse spectrum of cancers with notable global incidence and prevalence. The comprehensive care of individuals affected by these malignancies is a multifaceted endeavor involving the collaboration of various medical disciplines. The nonspecific clinical manifestations of GI cancers often present a formidable diagnostic challenge to primary care providers, resulting in diagnostic delays. Subsequently, the treatment regimens, once initiated, are often demanding and prolonged, and profoundly impact the patients' overall quality of life. Given the intricate involvement of the digestive system, nutritional concerns are pervasive among these patients, influencing both their quality of life and survival. Despite these considerable challenges, the evolving landscape of treatment modalities has yielded improved outcomes, enabling a greater number of patients to achieve remission or extended survival. It is now imperative that we delve deeper into understanding the unique needs of this patient population and refine the care delivery pathways through enhanced diagnostic approaches, treatment strategies, and holistic support, and ultimately enhance the overall value of care provided to individuals afflicted by GI malignancies.
    Keywords: HCV ; esophageal cancer ; male ; interferon ; mortality ; colorectal cancer ; gynecologic cancer ; retrospective cohort study ; colonoscopy screening ; gastric cancer ; ascites ; postoperative follow-up ; gastrectomy ; endoscopic submucosal dissection ; early gastric cancer ; type 2 diabetes mellitus ; glycemic control ; insulin resistance ; hepatocellular carcinoma ; annexin A2 ; prognostic marker ; survival outcome ; biliary tract cancer ; circulating tumor cell ; vimentin ; diagnosis ; prognosis ; gastric xanthelasma ; synchronous/metachronous gastric cancer ; genetic alteration ; predicting marker ; interval cancer ; screening ; endoscopy ; national cancer screening program ; c-Myc ; genetic linkage analysis ; cigarette smoking ; survival ; CRC ; CCL2 ; CCL4 ; CCL15 ; diagnostic utility ; gastrointestinal malignancies ; cancer survivorship ; calcium carbonate ; hypercalcemia ; cancer outcomes ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries.
    Keywords: infliximab ; etanercept ; TNFα inhibitors ; biologics ; biosimilars ; Germany ; policies ; incentives ; uptake ; market dynamics ; biosimilar market ; biosimilar/supply and distribution ; biosimilar sustainability ; Delphi technique ; pricing ; reimbursement ; utilization ; biosimilar ; biological ; information ; education ; communication ; patient ; Europe ; adalimumab ; biosimilarity assessment ; quality attributes (QAs) ; potentially critical quality attributes (pCQAs) ; European public assessment reports (EPARs) ; clinical governance ; Spain ; barriers ; regulatory ; review ; approval ; clinical ; queries ; regulatory science ; budget impact analysis ; savings ; pharmaceutical spending ; cost containment ; reference biological ; competitive market ; Belgium ; trastuzumab ; intravenous ; subcutaneous ; HER2-positive breast cancer ; drug costs ; healthcare costs ; cost simulation ; tender ; procurement ; off-patent ; award criteria ; switching ; interchangeability ; sustainability ; competition ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: This Special Issue on advanced sensor technologies contains contributions on the latest developments in mobile robotic systems and related research. Various topics with different ideas and applications from mobile robotics have found their place. New ideas are presented for mobile robots that specialise in cleaning floors, power lines and HVAC systems. We also find innovative approaches for navigation path planning using local minima-free potential fields, novel path primitives and/or their parameterisation for minimum-time planning, and various control approaches ranging from visual serving to model predictive and adaptive trajectory tracking, applied to wheeled robots, humanoid manipulators and flying robots. Localisation approaches using LiDAR, motion capture systems, fingerprint-based and biomechanical gait systems are also discussed. In addition to advances in methodology, applications in healthcare, mining tunnels, cleaning, warehouses and other areas are mentioned.
    Keywords: UAVs ; inspection and maintenance ; mobile robots ; insulators ; artificial intelligence ; mobile cleaning robot ; vibration source classification ; predictive maintenance ; deep learning ; 1D CNN ; defect detection ; Faster R-CNN ; object detection ; IoRT ; inspection robot ; navigation ; model predictive control ; path planing ; warehouse automation ; underground mining robots ; scan matching ; localization and SLAM in tunnels ; 2D lidar navigation ; GPS-denied environment ; robot navigation ; path planning ; potential field ; bilinear interpolation ; dynamic local re-planning ; domestic dirt ; dirt dataset ; audit robot ; cleaning benchmark ; dirt classification ; robot-aided cleaning auditing ; geometrical feature ; cleaning auditing ; swarm algorithms ; motion trajectory prediction ; kinematical models ; gait biomechanics ; spherical robot ; model ; simulation ; CoppeliaSim (V-REP) ; visual servoing ; autonomous landing ; monocular vision ; aerial robotics ; localization and SLAM ; 3D lidar ; range sensing ; Uniform Second-Order Sliding Mode Observer ; Prescribed Performance Control ; robot manipulators ; finite-time Stability ; feature detection ; light-weight mapping ; B-splines ; localization ; mobile robot ; complete coverage ; path smoothing ; velocity profile optimization ; humanoid robot ; state estimation ; motion capture ; Whole-Body Control ; ADHD ; screening ; skeleton ; position estimation ; indoor positioning ; sensor fusion ; RSSI ; magnetometer ; fingerprint ; wheeled mobile robots ; trajectory generation ; velocity profile ; trajectory optimization ; Bézier curves ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Researchers have made great progress in the mechanism of mycotoxins biosynthesis, pathogenicity, and the construction of detection methods. This collection holds fundamental and applied research on pathogenic fungi and mycotoxins in China, which directly or indirectly affect the health of plants, animals, and humans. Some papers mainly study the mechanism of mycotoxin biosynthesis, including the crucial genes, environmental factors, and regulation mechanisms, which is beneficial to advancing our knowledge of this area. Some papers focus on the toxicity of mycotoxins, which is helpful to the detoxification of mycotoxins and the reduction of the hazardous effect of mycotoxins. Special attention is given to the leading detection methods, especially on-site rapid detection. These effective and feasible methods are important for discovering and controlling the risk of mycotoxins.
    Keywords: water activity ; aflatoxin biosynthesis ; conidia development ; regulatory mechanism ; AtfB ; fumonisin B1 ; BALB/c mice ; fecal bacterial flora ; 16S rRNA sequencing ; zearalenone ; gilts ; ovary ; hormone ; weaned gilt ; intestinal morphology ; ghrelin ; PCNA ; farmers’ grain storage silos ; absolute water potential ; ventilation and drying ; mycotoxins ; contamination distribution ; Alternaria toxins ; modified QuEChERS method ; ultra-high-performance liquid chromatography-tandem mass spectrometry ; mixed fruit puree ; Aspergillus flavus ; AflN ; aflatoxin ; conidiation ; rice false smut ; ustiloxins ; generic antigen ; immuno-magnetic beads ; enzyme-linked immunity ; hepatotoxicity ; nephrotoxicity ; haematological toxicity ; regulatory limit ; αB-conotoxin VxXXIVA ; epitope ; hybridoma ; monoclonal antibody ; ELISA ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 68
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: This Special Issue delves deeply into the intricate distinctions between acute and chronic pain. Crucially, chronic pain is more than a mere by-product of sensory input; it entails the activation of a complex brain network intertwined with biopsychosocial factors. As such, its management emerges as a formidable clinical challenge. Within the scope of this Special Issue, focused attention is given to postoperative pain (POP) and chronic postsurgical pain (CPSP). POP, characterized by its predictability, intensity, and short duration, contrasts starkly with the potentially persistent and troublesome nature of CPSP, which can endure for over three months if not adequately addressed. The prevention of CPSP takes on paramount importance, with regional anesthesia techniques emerging as promising tools for intervention. The pivotal role of multimodal analgesia and combined therapeutic strategies is underscored. The Special Issue also delves into the intriguing realm of gender differences in pain perception, advocating for further research to illuminate these disparities. Risk factors contributing to the development of chronic pain following surgery are meticulously identified. Lastly, this Special Issue explores the potential of new technologies in the field of telemedicine and artificial intelligence to optimize care delivery, opening new avenues for enhanced patient outcomes and treatment strategies.
    Keywords: Postoperative pain ; Chronic postoperative pain ; Pain mechanisms ; Postoperative pain management ; Physiopathology of chronic postoperative pain ; Opioids ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: The reliability of high-voltage equipment is critical to the safe operation of the power grid. This reprint focuses on the new developments and advances in both fundamental and applied research on the testing, monitoring, and diagnostics of high-voltage equipment, including insulators, transformers, etc.
    Keywords: HV bushing ; dielectric response ; paper–oil insulation ; temperature distribution ; distribution transformers ; failure analysis ; monitoring ; diagnostic method ; frequency response ; open and short-circuit response ; hydro-generators ; partial discharges ; PD Spectral Pulse Counting Map (PD-SPCM) ; microstrip antenna ; UHF method ; Frequency Resolved Partial Discharges (FRPD) ; AC breakdown characteristics ; arresters ; lightning protection insulator ; electric field calculation ; icing conditions ; cable insulation ; contact surface ; dielectric breakdown ; electrical breakdown ; polymeric insulation ; solid–solid interface ; surface roughness ; insulator ; deicing ; hot water jet ; numerical calculation ; temperature spatial distribution ; pollution insulators ; nonsoluble deposit density ; flashover characteristics ; arc parameters ; high voltage apparatus ; deep learning ; classification ; localization ; partial discharge ; faults ; outdoor insulators ; railway electrification system ; outdoor porcelain insulators ; low-frequency flashover AC voltage ; lightning impulse critical-flashover voltage ; icing ; anti-icing ; de-icing transmission lines ; ice-melting ; icing disaster ; diameter-expanded conductor ; current transferred ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The book showcases a review and empirical studies on life satisfaction and its related aspects. The studies are from several countries on a wide range of samples including university students, faculty, nurses, entrepreneurs, adolescents, national databases, refugees, and community samples.
    Keywords: Life satisfaction, Subjective Well-Being, Happinees, Quality of Life, Psychological Well-Being ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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    Publication Date: 2024-04-09
    Description: This reprint is a collection of papers published in a Special Issue that collected the recent advances within and investigations of the research fields of manufacturing and the characterisations or modelling of materials. The variety and quality of all these papers are addressed to both academic and industrial researchers who are looking for new information that can contribute to the advancement of future research in these highly challenging fields.
    Keywords: ATIG welding ; mixing design method ; particle swarm optimization (PSO) ; pseudo-ternary flux ; 316L SS ; mathematical modeling ; mechanical properties ; microstructure ; dynamic deformation behavior ; Cowper-Symonds model ; texture ; Hall–Petch relationship ; textile signal lines ; textronic systems ; data transmission over textiles ; smart textiles ; characteristic impedance ; signal quality tests ; smart garments ; e-textiles ; steel bar structures ; parametric design ; genetic algorithms ; structural optimization ; lightweight structures ; manufacturing and processing ; laminated composite double-cylindrical shell system ; improved Fourier series ; Rayleigh–Ritz method ; free vibration ; steady-state response ; hydrogen embrittlement ; nanograined materials ; intergranular deformation ; brittle fracture ; grain refinement ; magnesium alloy AZ91 ; short carbon fibers ; compressive strength ; wear resistance ; wear mechanisms ; wear debris ; hydrogen ; hydrogen fuel cell ; depressurization ; orifice plate structure ; computational fluid dynamics ; numerical model ; roughness surface ; morphological characterization ; characterization parameter set ; redundant parameter set ; ISO25178 ; face gears ; 3D optical scanning ; point clouds ; tooth surface deviations ; loaded tooth contact analysis ; meshfree method ; laminated composite shell ; rotating shell ; free vibration analysis ; thermal effect ; Rayleigh–Ritz technology ; laminated submarine-like model ; annular plate ; vibration analysis ; molecular dynamics ; dislocation nucleation ; plastic deformation ; aluminum alloys ; AA6082-T6 ; AA2011-T6 ; friction stir spot welding ; friction stir deposition ; keyhole refilling ; ultrasonic-assisted thermal forming ; ultrasonic softening effect ; stress reduction amplitude ; evolution of microstructure ; AZ91D magnesium alloy ; laser cladding ; Al-Si + Y2O3 coating ; tribological property ; corrosion resistance ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue summarizes, in a single reference, timely emerging topics related to power electronics for sustainable energy conversion. Furthermore, at the same time, it provides the reader with valuable information related to open research opportunity niches.
    Keywords: constant power load ; boost converter ; discontinuous conduction mode ; nonlinear control ; switched system ; fractional-order PID controller ; DC–DC converters ; Non-minimum phase systems ; experimental validation ; renewable energy sources ; dc-dc power electronic converters ; energy efficiency ; switching DC-DC converters ; quadratic converter ; PV systems ; fuel cell ; new equivalent electrical model of fuel cell ; PEMFC NEXA 1200 ; comparative study ; multilevel inverter ; power electronics ; staircase modulation ; vector modulation ; ultrawide bandgap ; semiconductors ; neutral point clamped ; inverter ; silicon ; gallium trioxide ; fabrication ; hybridization ; PV generation ; space vector modulation ; transformerless inverters ; grid connection ; leakage ground current ; wind turbine generator (WTG) ; permanent magnet synchronous generator (PMSG) ; low voltage ride-through (LVRT) ; silicon carbide (SiC)-based inverter ; core losses methods ; power losses ; ferromagnetic material ; inductors ; transformers ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The development of in vivo neuroimaging techniques has yielded an incredible amount of digital information about the brain. Neuroimaging techniques are increasingly being used to study human cognitive processes, create brain–machine interfaces, and also to identify and diagnose certain brain disorders. Currently, neuroscientists and medics actively use different methods for brain scans, including electro- and magnetoencephalography (EEG/MEG), functional near-infrared spectroscopy (fNIRS), electrocorticography (ECoG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and diffusion tensor imaging (DTI). Recent advances in signal processing and machine learning for neuroimaging data using various signal processing methods have made impressive progress in solving a number of practical tasks in medicine, healthcare, neuroscience, biomedical engineering, brain–machine interfaces, and cognitive science, to name but a few. This Special Issue aims to provide a forum for academic and industrial communities to present and discuss the latest theoretical and experimental results related to recent advances in neuroimaging data processing in terms of new theories, algorithms, architectures, and applications.
    Keywords: MEG ; FieldTrip ; Brainstorm ; source reconstruction ; flickering ; cognitive neuroscience ; visual perception ; detrended fluctuation analysis ; long-range correlations ; electroencephalogram ; sleep deprivation ; nonstationarity ; transfer entropy ; kernel methods ; Renyi’s entropy ; connectivity analysis ; phase interactions ; brain data ; low-cost devices ; EEG ; BIDS ; neuroscience ; library ; ambiguous stimuli ; Necker cubes ; classification task ; EEG analysis ; wavelet analysis ; decision time ; perceptual errors ; time-on-task effect ; brain connectivity ; artificial neural networks ; granger causality ; time series ; brain–computer interface ; event-related potential ; beamforming ; regularization ; BCI ; graphical user interface ; wheelchair navigation ; grid map ; natural landmark ; optimal paths ; deep Q-networks ; focal epilepsy ; diffusion imaging ; electroencephalography ; structure-function coupling ; seizure onset ; structural connectivity ; functional connectivity ; cognitive load ; coupling ; bubble entropy ; transition network ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Non-destructive testing and evaluation are commonly referred to as the vast group of analysis techniques used in civil, medical, and industrial sectors to evaluate the properties of materials, tissues, components, or structures, without causing any damage. Automation offers many benefits for non-destructive testing to cope with increasing demands, including improved reliability and higher inspection speeds. Additionally, robots enable inspections in locations that are not easily accessible to human operators and allow for humans to be removed from potentially dangerous environments. However, the perceived complexity and high costs have limited the adoption of automation. As a result, the full potential that could be derived from the seamless integration of robotic platforms with sensors, actuators, and software has not been fully explored; it could still revolutionise the way that automated inspections are performed and conceived. The recent advancements in electronics, robotics, sensor technology and software pave the way for new developments in automated testing and data-driven autonomous robotic inspections in several sectors. This Special Issue aimed to attract the latest research outcomes in the field of robotic sensing. Five papers relate to inspection systems based on robotic fixed-base manipulators, three of which are associated with in-process inspection in manufacturing applications (robotic wire-arc welding and additive manufacturing). Four papers report research advancements in mobile robotic-enabled sensing.
    Keywords: wall-climbing robot ; passive adaptive mechanism ; magnetic circuit optimization ; flexible detection method ; welding robot ; seam tracking ; laser sensor ; feature point extracting ; complex welding seam ; UAVs ; inspection ; soft robotics ; non-destructive evaluation ; robotic NDE ; robotic welding ; robotic control ; in-process NDE ; ultrasonic NDE ; ultrasound ; image motion analysis ; image processing ; optical flow ; underwater robotic ; NDT ; free-form surface profiling ; autonomous robotic systems ; in-process robotic NDE ; Wire + Arc Additive Manufacture (WAAM) ; ultrasound testing ; total focusing method ; defect recognition ; aircraft inspection ; deep learning ; CNN ; UAV ; defect classification ; AI ; underwater vehicle–manipulator system ; robotics emulator ; contact management ; remote inspection ; force control ; automated eddy current testing ; eddy current arrays ; robotics ; thermography ; non-destructive testing ; image alignment ; image blending ; n/a ; bic Book Industry Communication::M Medicine
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  • 75
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The first three papers describe research activities about poly(lactic acid) (PLA)-based blends and their composites with wheat bran that were carried out under the framework of the BIONTOP project ("Novel Packaging Films and Textiles with Tailored End of Life and Performance Based on Bio-based Copolymers and Coatings", 837761) funded by the European Commission BBI-JU program. The melt fluidity, morphological, thermo-mechanical, creep and fracture properties of these promising biodegradable materials were considered and discussed. The reprint then includes two contributions (a review and a research article) written in the contest of ECOFUNCO project ("ECO Sustainable Multi FUNctional Biobased COATings with Enhanced Performance and End of Life Options", 837863) funded by the European Commission BBI-JU program. The review explores possible innovations in the field of solid and liquid biobased coatings, whereas the research article examines the modification of paper tissues with biobased additives for sustainable personal care applications. A research paper on the production of PLA-based composites to valorize hazelnut shell powder, which represents an agro-food waste, is also included in the reprint. Moreover, the reprint presents research papers investigating different biobased materials for environmental depollution, including hydrogel-based, bacterial cellulose-based and biochar-based materials. Finally, a research paper on the behavior of natural rubber during aging is presented.
    Keywords: bacteria cellulose ; poly Schiff base ; chromium ; adsorption ; poly(lactic) acid (PLA) ; poly(butylene succinate-co-adipate) (PBSA) ; binary blends ; micromechanical analysis ; mechanical tests ; polyurethane-biochar crosslinked material ; modified filter additive ; phosphorus release and adsorption ; bioretention facilities ; stormwater treatment ; rubber waterstop ; low temperature ; aging performance ; microscopic examination ; mechanism analysis ; fibrillated nanocellulose ; hydrogel ; methyl orange ; polymer ; creep ; micromechanics ; coatings ; active molecules ; barrier properties ; biocomposites ; natural fibers ; poly(lactic acid) (PLA) ; extrusion compounding ; fracture mechanics ; chitin nanofibrils ; polyphenols ; paper tissues ; mechanical properties ; bio-based coatings ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: The year 2021 marks the 10th anniversary of Journal of Clinical Medicine, and as one of the major sections of JCM, we are launching a 10th anniversary Special Issue in the section “Gastroenterology & Hepatopancreatobiliary Medicine”. We accepted papers for the Special Issue, titled "Recent diagnostic and therapeutic advance in Gastroenterology & Hepatopancreatobiliary Medicine". This medical field is a complex and wide-ranging field that deals with diseases in multiple organs such as the gastrointestinal tract and hepatobiliary pancreas. With recent advances in diagnostic imaging and interventional treatment, those in endoscopic diagnosis and treatment, those in functional test and those in genetic diagnosis and drug therapy, including the molecular-targeted therapy, many new medical findings have been accumulated. In this Special Issue, we looked for reports that make full use of advances in diagnostics and therapeutics in the field of Gastroenterology and Hepatopancreatobiliary Medicine.
    Keywords: TXI ; sessile serrated lesion ; hyperplastic polyp ; colonoscopy ; endoscopic submucosal dissection ; colorectal tumor ; traction method ; carbon dioxide ; CO2 insufflation ; abdominal pain ; abdominal distention ; transnasal endoscopy ; health check ; tranexamic acid ; gastrointestinal bleeding ; mortality ; thromboembolic events ; liver metastases ; colorectal liver metastases ; non-colorectal and non-neuroendocrine liver metastases ; liver resection ; Crohn’s disease ; biologics ; small-molecule drugs ; health-related quality of life (HRQoL) ; gastric cancer ; gastric cancer screening ; endoscopy ; H. pylori ; eradication therapy ; n/a ; functional bowel disorders ; gut microbiota ; personalized diet ; machine learning ; personalized medicine ; Turkey ; machine perfusion ; normothermic ; hypothermic ; liver transplant ; survival ; ustekinumab ; perianal fistula ; radiological fistula remission ; metastatic pancreatic carcinoma ; FOLFIRINOX ; sarcopenia ; oxaliplatin ; L3 skeletal muscle index ; percutaneous endoscopic gastrostomy ; prognostic factor ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue is committed to focusing on highly relevant state-of-the-art advances in the monitoring, diagnosis, and optimisation of water systems, aiming to provide a broad spectrum of reference methods and techniques specially focused on water cycle applications, including fault detection (namely, leak localisation to reduce the loss of water due to leaks, which may account for up to 65 % of the total water depending on the network) or water quality modelling in Water Distribution Networks (WDNs), as well as different methodologies applied to water sanitation. Here, there is growing interest in the adaptation and use of technologies related to the circular economy that promote environmental sustainability, in which resource recovery is a key issue for industrial and environmental processes and shows a wide spectrum of study possibilities, especially in wastewater treatment plants (WWTPs). This is mainly related to sludge treatment processes such as biogas generation via the substrate co-digestion process, which can be an alternative source for thermal and electrical energy production, as well as a source of renewable natural gas. Hence, all the contributions in this Special Issue have an impact on the advances in the monitoring, diagnosis and optimisation of water systems and, overall, cover a wide and complete sector of knowledge within this area.
    Keywords: [diagnosis] ; [real-time monitoring] ; [waste water treatment plants] ; [anaerobic co-digestion] ; [optimisation] ; [resource recovery] ; [intelligent decision support systems] ; [water sanitation] ; [water distribution] ; [sensor placement] ; [remote sensing] ; [water quality] ; [water monitoring] ; [water supervision] ; [water modelling] ; [water control] ; [artificial intelligence] ; [artificial neural networks] ; [water systems] ; [environmental systems].&nbsp ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies.
    Keywords: ciguatoxins ; HRMS ; Q-TOF ; ciguatera poisoning ; C-CTX1 ; fragmentation pathways ; maitotoxins ; Gambierdiscus ; Fukuyoa ; LC-MS/MS ; QToF ; neuroblastoma cell assay ; matrix effect ; ciguatera monitoring ; SPATT passive samplers ; HP20 resin ; CBA-N2a ; WS artificial substrate ; qPCR ; HTS metabarcoding ; ciguatera ; ciguatoxin ; cytotoxicity assay ; ELISA ; HPLC ; immunoassay ; mouse bioassay ; receptor-binding assay ; ciguatoxins (CTXs) ; neuroblastoma cell-based assay (CBA) ; immunosensor ; pacific ciguatoxins ; natural product ; polycyclic ether ; ring-closing metathesis ; Tsuji-Trost allylation ; French Polynesia ; epidemiology ; toxicological analyses ; risk management ; climate change ; Gambierdiscus polynesiensis ; toxin profile ; nitrate ; urea ; culture medium acidification ; CTX1B ; 52-epi-54-deoxyCTX1B ; 54-deoxyCTX1B ; Dictyota ; Caribbean ; dinoflagellate ; benthic algae ; algal toxin ; harmful algal bloom ; the Indian Ocean ; Arabian sea ; Kuwait bay ; Aden Gulf ; Red Sea ; Gulf of Aqaba ; Andaman Sea ; Bay of Bengal ; seafood safety ; foodborne disease ; experimental exposure ; lionfish ; trophic transfer ; toxin accumulation ; Selvagens Islands ; morphology ; phylogeny ; benthic dinoflagellate ; Beibu Gulf ; Chinese waters ; least absolute shrinkage and selection operator ; machine learning ; data science ; medical informatics ; survival analysis ; foodborne diseases ; Ciguatera Fish Poisoning ; digital technologies ; open data ; risk analysis ; marine biotoxins ; Lagodon rhomboides ; pinfish ; bioaccumulation ; depuration ; Caribbean ciguatoxin ; growth dilution ; model ; kinetics ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Billions of people suffer from dental problems. Paradoxically, the deteriorating state of teeth is accompanied by the ever-increasing desire to preserve the best facial appearance, which is significantly influenced by teeth aesthetics. This favors the development of dental materials and manufacturing technologies for dental prosthetics, needed to achieve expected effects of clinical treatment.This reprint focus on enhancing antimicrobial and mechanical properties of polymeric materials and composites for dentistry. In recent years, special attention has been focused on the possibility of giving materials new or improved properties by the introduction of nano or submicron size additives, fibers or whiskers. Using agents such as natural oils to enhance antimicrobial properties remains an exciting idea. Another area of research is the application of antibacterial monomers, which can be copolymerized in resins to kill oral pathogenic microflora. The use of new monomers or new compilations of various monomers to improve mechanical properties has also aroused interest. In addition, we are currently looking for new data regarding colonization of dental materials by pathogenic microbes and their influence on the other properties. Further, there are many new commercially available materials which should be investigated to verify their properties, which is important from the point of view of clinical practice. Original new research and reviews related to any of the topics mentioned above indicate the current directions of development of dental materials. We hope that the presented work will be of interest to readers.
    Keywords: dental cements ; ethanol ; water ; resistance ; DTS ; Vickers hardness ; dental materials ; dimethacrylates ; polymer networks ; structure ; morphology ; degree of conversion ; crosslink density ; physical crosslinking ; hydrogen bonds ; mechanical properties ; water sorption ; polymethyl methacrylate ; denture ; antibacterial properties ; silver ; sorption ; solubility ; wear resistance ; FRC ; bonding ; technique ; fiber ; reinforced ; composite ; spot ; mechanical ; deflection ; orthodontics ; brushing ; wear ; retainer ; splint ; load ; direct pulp capping ; indirect pulp capping ; ProRoot MTA ; MTA Angelus ; retroMTA ; biodentine ; theraCal LC ; ACTIVA BioACTIVE ; vital pulp therapy ; glass fiber ; composite post ; endodontic therapy ; etching ; post and core technique ; silane ; glass-ionomer cements ; resin-modified ; fibre ; reinforcement ; nanoparticles ; testing ; strength ; P2O5-bioglass ; zirconia ; melt-quenching ; SBF ; hydroxyapatite ; in vitro bioactivity ; essential oils ; oral pathogens ; antibacterial activity ; S. mutans ; L. acidophilus ; C. albicans ; antifungal activity ; resin composite ; wettability ; biofilm formation ; cytotoxicity ; polymers ; antimicrobial properties ; infiltrants ; metronidazole ; dental ceramics ; spectroscopy ; IR ; FT-IR ; Raman spectroscopy ; UV-Vis ; X-ray spectroscopy ; XRF ; XRD ; MS ; dental resins ; UDMA ; Bis-GMA ; Bis-EMA ; TEGDMA ; hardness ; water absorption ; water dissolution ; CAD-CAM ; inlay ; lithium disilicate ; zirconium dioxide ; root caries ; infiltration ; microstomatology ; adhesive ; bracket ; dentures ; denture adhesives ; human fibroblasts ; composite resins ; Streptococcus mutans ; dental caries ; bacterial adhesion ; oleic acid ; PMMA ; filamentation ; biofilm ; antimicrobial surface ; Candida albicans ; colonization ; penetration ; dimethacrylate copolymers ; quaternary ammonium methacrylates ; urethane-dimethacrylates ; photocurable copolymers ; water behavior ; thermoplastic materials ; laboratory protocol ; texture ; roughness ; biomaterial ; polymer ; microbial degradation ; artificial saliva ; mucins ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue on Interdisciplinary Research for Cultural Heritage Conservation in Applied Sciences aims to bring together some of the latest researches in this field. A total of 10 papers focusing on different aspects of cultural heritage were published on the topics: rock art, mural paintings, stone monuments, stained-glass windows, environmental sensors, historic infrastructures, and analects of Confucius.
    Keywords: Deterioration of building stones ; biodeterioration ; rock weathering ; rock art ; petroglyphs, cleaning of phototrophic biofilms ; mural paintings ; vandalized monuments ; restoration ; stained-glass windows ; chemical sensors ; water supply public work ; Lunyu ontology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: In this Special Issue, we sought advanced knowledge in both basic and clinical research presented in original articles and comprehensive reviews highlighting the latest advances in MCC. Articles focus on but were not restricted to the molecular basis of the disease, translational investigations of biomarkers for prospective clinical applications, and innovative diagnostic and therapeutic approaches in MCC.
    Keywords: miR-375 ; antagomiRs ; Merkel cell carcinoma ; Hippo signaling ; focal adhesion ; diagnosis ; treatment ; review ; guideline ; Merkel cell polyoma virus ; tumor microenvironment ; CD8 lymphocytes ; ulceration ; E-cadherin ; artesunate ; MCC ; polyomavirus ; ferroptosis ; radiation therapy ; immunotherapy ; surgical intervention ; survival ; multidisciplinary communication ; biomarkers ; cell tropism ; signaling pathways ; therapy ; transgenic mice ; tumorigenesis ; histogenesis ; ATOH1 ; GLI1 ; sonic hedgehog ; hair follicle ; Merkel cell polyomavirus ; skin carcinogenesis ; T antigens ; human polyomaviruses ; DNA tumor viruses ; viral oncoproteins ; merkel cell carcinoma ; merkel cell polyoma virus ; sex ; radiotherapy ; UV ; cell line ; MYC ; TP53 ; RB1 ; whole-exome ; significantly mutated genes ; copy number variation ; virus positive Merkel cell carcinoma ; virus negative Merkel cell carcinoma and copy number variant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: In the treatment of acute stroke, thrombolysis and thrombectomy have proven to be highly effective. Many patients have seen significant improvement after reperfusion therapy. This reprint aims to address current knowledge gaps and promote advancements in the use of thrombolysis and thrombectomy for the treatment of acute ischemic stroke.
    Keywords: ischemic stroke ; acute kidney injury ; contrast media ; endovascular treatment ; outcome ; hyperglycemia ; acute ischemic stroke ; large vessel occlusion ; mechanical thrombectomy ; stroke ; ischemia ; machine learning ; cerebral infarction ; biomarkers ; recanalization therapy ; reperfusion ; temperature ; time to admission ; prehospital delay ; prior stroke ; basilar artery ; brain ischemia ; intracranial atherosclerosis ; embolism ; infarction ; clinical symptoms ; intravenous thrombolysis ; endovascular therapy ; recanalization times ; clinical outcome ; hypoperfusion index ratio ; collateral circulation ; collateral scoring ; CTA ; CTP ; thrombolysis ; C-reactive protein ; white blood cell count ; prognosis ; hypoperfusion ; collaterality ; thrombectomy ; frailty ; elderly patients ; hospital frailty risk score ; acute stroke ; perfusion imaging ; CT perfusion ; MR perfusion ; RAPID ; fasting hyperglycemia ; fasting normoglycemia ; long-term outcome ; hemorrhagic transformation ; parenchymal hematoma ; GWAS ; single nucleotide variants ; anterior circulation ; bridging therapy ; recanalization ; stroke risk score ; COVID-19 ; Lithuania ; reperfusion therapies ; outcomes ; safety ; prehospital stroke diagnosis ; ultrasound ; brain perfusion ; SONAS® ; prehospital stroke scales ; point-of-care diagnostics ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 83
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Plant stress could be defined as any unfavorable condition or substance that can affect or block the metabolism, growth or development of a plant. The response of the plant may vary depending on the frequency and intensity of the stressor, as well as the developmental stage of the plant. Plants, throughout their life cycle, are exposed to a large number of conditions or stressors. Abiotic stress is stress caused by non-living agents. Depending on the nature of the causal agent, it can be divided into physical and chemical. Physical (actually, physical-chemical) stresses include water deficits, salinity (in its osmotic component), temperature extremes (heat, cold, freezing), excessive or insufficient irradiation, anaerobiosis caused by waterlogging or flooding, mechanical stress caused by wind or excessive soil compaction and stress induced by wounds or injuries. Chemical stress is caused by salinity (in its ionic or toxic component), by the lack of mineral elements and by environmental pollutants such as sulphur dioxide (SO2), nitrogen oxides (NOx), chlorofluorocarbon compounds (CFCs), ozone (O3) and metals. The abiotic stresses that most negatively affect growth and production are probably drought, salt stress and temperature stress (high and low temperatures), all of which are associated with climate change.
    Keywords: gene bank ; germination ; orthodox seeds ; priming ; reactive oxygen species ; deficit irrigation ; plant physiology ; ornamental plants ; water relations ; water-use efficiency ; abiotic stress ; climacteric fruit ; ethylene scavengers ; fruit quality ; potassium permanganate ; Prunus persica ; UV radiation ; climate change ; soilless agriculture ; blossom-end rot ; tipburn ; calcium deficiency ; basil ; heat stress ; metabolome ; transcriptome ; molecular mechanism ; antioxidase ; factor analysis ; ion homeostasis ; osmoregulatory substance ; salicylic acid ; salt stress ; Melia azedarach ; provenance ; water deficit ; physiology response ; comprehensive evaluation ; chilling stress ; phenolics ; momilactones ; gene expression ; biosynthesis ; ultra-performance liquid chromatography-electrospray ionization-mass spectrometry ; real-time quantitative polymerase chain reaction ; L-arginine ; phenological periods ; regulated deficit irrigation (RDI) ; root reserves ; yield ; brassicas ; hyperspectral reflectance ; imaging sensors ; plant phenotyping ; multicolor fluorescence imaging ; thermography ; vegetation index ; salt tolerance ; Triticum aestivum L. ; Triticum durum Desf. ; autophagy ; mitophagy ; PCD ; ROS ; electromagnetic field ; seed priming ; eustress ; seed aging ; phytohormones ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: As Editor-in-Chief of the journal Diabetology, I am pleased to announce that the Special Issue “Diabetology: Feature Papers 2022” has now been published as a reprint. Diabetology (ISSN 2673-4540) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to the epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In this Special Issue, “Feature Papers”, we aimed to publish outstanding contributions in the main fields covered by the journal, which will make a great contribution to the community. This reprint covers the whole spectrum of diabetology from risk screening, risk markers, pathways of disease in type 1 diabetes and insulin treatment, and management of the disease and comorbidities.
    Keywords: older people ; diabetes mellitus ; management ; insulin therapy ; frailty ; sarcopenia ; type 1 diabetes ; type 2 diabetes ; insulin ; beta cell preservation ; verapamil ; thioredoxin-interacting protein (TXNIP) ; Chronic Care Model ; self-management of type 2 diabetes ; chronic disease ; healthcare system of Pakistan ; patients’ quality of life ; obstructive sleep apnoea ; DM ; obesity ; inflammation ; polysomnography ; coronavirus disease 2019 ; COVID-19 ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; diabetes ; diabetic ketoacidosis ; DKA ; hyperglycemia ; mortality ; innate immunity ; cytokine storm ; angiotensin-converting enzyme 2 ; pancreatic β-cell damage ; pediatrics ; HbA1c ; telemedicine ; continuous glucose monitoring ; prediabetes ; liver enzymes ; rhenium (V) compound ; triglycerides ; NAFLD ; fructose ; injection technique ; lipohypertrophy ; sodium glucose co-transporter 2 (SGLT2) inhibitors ; nocturia ; sodium intake ; key informant interviews ; prevention of type 2 diabetes ; National DPP ; DSMES ; telehealth ; provider experiences ; lipodystrophy ; clinical detection ; recommendations ; rehabilitation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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  • 85
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Electronic cigarettes (ECs) have been present on the consumer market for over a decade, and the number of related scientific publications in the PubMed database has now exceeded seven thousand. Despite the number of publications, there is still no consensus in the scientific community regarding their safety. However, it should be emphasized that a comparison of equivalent quantities of tobacco smoke and the aerosol produced from e-cigarettes showed that there was a significantly lower quantity of toxic compounds in the aerosol compared with the tobacco smoke. Therefore, the use of ECs could be seen as a way of reducing the health damage to cigarette smokers who cannot or are unwilling to quit using conventional methods. In addition, randomized studies are emerging suggesting that ECs could be useful in smoking cessation. On the other hand, ECs are now widely used among adolescents and may pose a serious risk of future nicotine dependence and health problems in this population, as they counteract their advantages in the population gained from smokers who quit using them. Therefore, as most authors stress, further research that will convincingly resolve the current controversies is needed. Clinicians urgently need evidence-based knowledge to better inform their patients about the use of these emerging tobacco products as a harm-reduction strategy, and regulators should regulate these products in ways that best serve public health, especially taking the youth population into account.
    Keywords: e-cigarettes ; global health ; vaping ; tobacco smoke ; toxicants ; cessation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: In the last century, the average life expectancy at birth increased from roughly 45 years in the early 1900s to more than 80 years of age at present. However, living longer is often related to different levels of frailty. There is no curative treatment for frailty—the interventions that have been described as effective to slow or delay the onset of frailty are physical activity and nutritional interventions. Maintaining adequate nutrition status is important to reduce the risk of chronic diseases, many of which are age-related. On the other hand, frailty itself may have a negative effect on eating and, thus, on the nutritional status. This Special Issue, "Nutrition, Diet Quality, Aging and Frailty", addresses the existing knowledge on nutrition regarding the causative factors of frailty and disease due to aging, i.e., strategies for delaying the pathological effects of aging. It consists of twelve peer-reviewed papers covering original research, protocol development, methodological studies, narrative or systematic reviews, and meta-analyses, to better understand these complex relationships.
    Keywords: diet ; metabolism ; nutrient ; glucose ; lipid ; insulin ; neuroinflammation ; Alzheimer’s disease ; anti-ageing ; eating habits ; functional foods ; skin ageing ; breakfast ; meals ; older adults ; protein intake ; hyperhomocysteinemia ; vitamin B deficiency ; amyloid beta-peptides ; disease models ; animal ; memory and learning tests ; dietary diversity ; activities of daily living ; cohort study ; adults ; mortality ; QOL ; ADL ; Serum albumin ; self-assessed chewing ability ; inflammaging ; cognitive impairment ; cytokines ; physical frailty ; aged ; dietary inflammatory index ; dietary patterns ; frailty ; inflammation ; muscle function ; muscle mass ; sarcopenia ; prevalence ; nutrition ; physical activity ; meta-analysis ; meta-regression ; dairy products ; dietary pattern ; malnutrition ; food groups ; Mediterranean dietary pattern ; Westernized dietary pattern ; cross-sectional study ; aging ; lifespan ; carbohydrates ; whole grain ; protein ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The growing population is forcing us to look for new, more effective solutions to various problems. The rising demand for power, water supply and waste management, pedestrian safety, the efficient use of electric vehicles, traffic jams, commuting, the identification of all road users and prediction of their travel paths, and increasing air and noise levels are the most pressing issues in today’s cities. Advance planning is a feature of green development that reduces dependence on vehicles associated with an increase in greenhouse gas emissions. The development of eco-friendly cities includes the development and application of new efficient solutions and technologies, such as efficient transport management, emission control and pollution control, energy efficiency and the usage of renewable energy, resource efficiency, etc., which would ensure a better quality of life of the growing population.
    Keywords: waste management ; sustainability ; eco-friendly city ; design thinking ; infectious waste ; resource efficiency ; communication technology ; beacon ; large-scale ; unmanned vehicle ; ad hoc network ; hybrid routing protocol ; air pollution ; drone ; land survey ; visual recognition algorithm ; fast R-CNN ; dust sensors ; microcontroller ; VMD ; LSTM ; coal thickness ; seismic attribute ; distributed manufacturing ; rescheduling ; memetic algorithm ; arrhythmia ; driving restrictions ; adaptive digital filter ; noninvasive method ; heart rate ; spherical microphone array ; sound source identification ; functional delay and sum beamforming ; denoising ; performance enhancement ; eco-friendly networks ; wireless sensor network ; energy efficiency ; low-power networks ; Markov model ; log-normal fading ; excavator ; typical working condition ; load ; operating data ; energy flow ; mathematic model ; cardiovascular system ; seismography ; modeling ; loader ; bucket fill factor ; material surface three-dimensional information ; regression prediction ; RecurDyn ; EDEM ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories.
    Keywords: developmental origins of health and disease (DOHaD) ; gut microbiota ; hypertension ; short chain fatty acid ; oxidative stress ; probiotics ; prebiotics ; renin–angiotensin system ; fibroblast growth factor-23 ; left ventricular hypertrophy ; renin–angiotensin–aldosterone system ; losartan ; canrenone ; Hyp mice ; X-linked hypophosphatemia ; hairless SHRM ; cold acclimation ; cardiac Cx43 ; extracellular matrix ; thyroid hormones ; SHR ; sacubitril/valsartan ; ARNI ; ivabradine ; remodelling ; cardiac dysfunction ; fibrosis ; angiotensin II ; angiotensin 1-7 ; knock-out ; genome-editing ; SHRSP ; Dahl SS ; foetal programming of hypertension ; sympathetic neurotransmission ; sympathetic innervation ; vascular remodelling ; foetal undernutrition ; old SHR ; antihypertensive therapy ; blood pressure monitoring ; LV hypertrophy ; ECM markers ; cardiac fibrosis ; SHR-CRP ; SGLT-2 inhibitor ; gene expression ; age ; lipid metabolism ; nitric oxide ; l-NAME ; rostral ventrolateral medulla ; aging ; reactive oxygen species ; NADPH oxidase activator 1 ; mitochondria ; chloride ; calcium-activated chloride channel ; Na+–K+–2Cl− cotransporter 1 ; TMEM16A ; smooth muscle ; fetal undernutrition programming ; cross-fostering ; lactation period ; cardiovascular hypertrophy ; adipose tissue browning ; cardiovascular disease ; catecholamines ; liquid chromatography–tandem mass spectrometry ; SGLT-2 inhibition ; proteinuria ; uninephrectomized salt-loaded ; two-kidney ; one-clip hypertension ; fawn-hooded hypertensive rat ; ApoE KO ; apolipoprotein E knockout mice ; atherosclerosis ; Na,K-ATPase ; TCTP ; TCTP-overexpressing transgenic mice ; translationally controlled tumor protein ; TCTP-TG ; experimental hypertension ; bone ; rats ; taurine ; magnesium ; 24 h urine(24U) ; stroke-prone spontaneously hypertensive rat ; young SHR ; combination therapy ; treatment effect ; systolic blood pressure ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This reprint aims to promote and disseminate applied research in the field of corrosion of steel structures and technological equipment. Within the text, the focus is firmly placed on the detailed study of corrosion processes affected by specific environments, as well as on the effects of corrosion damage on the reliability and service life of structural components and technological equipment. Special attention is paid to the study of the impact of corrosion processes on pipelines.
    Keywords: Q235B steel ; desulfurization solution ; corrosion mechanism ; pitting corrosion ; high pressure and high temperature ; O2–CO2 coexistence environment ; flow-induced corrosion ; reinforcing steel ; corrosion ; chloride ; experiment ; bow shaped device ; concrete ; cathodic protection ; buried pipelines ; rust layer ; electrochemical acceleration test ; applied current density ; required current ; low-alloy steel ; SEM ; inclusion ; anodic dissolution ; steel pipeline ; in-line inspection results ; interacting corrosion defects ; structural integrity ; galvanostatic test method ; underground infrastructure ; long-term corrosion ; carbon steel ; ASTM A516-65 steel ; weld ; hydrogen-induced cracking ; galvanic corrosion ; sour environment ; vinyltrimethoxysilane ; silane ; sol–gel ; response surface methodology ; Box–Behnken design ; modeling ; soil environment ; carbon steel corrosion ; stray current corrosion ; pipeline ; calcareous deposit ; corrosion mitigation ; failure analysis ; low-carbon steel pipe ; aluminum inclusions ; pearlite inhomogeneity ; steel structures ; crevice corrosion ; lattice towers ; bolted lap joints ; weathering steel ; experimental tests ; numerical modelling ; corrosion current density ; sulfate ; galvanized steel ; alkaline solutions ; linear polarization resistance ; electrochemical impedance spectroscopy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint is a collection of papers in materials science and materials science with a focus on applications and social implementation. The core of this reprint is based on the papers presented at the symposia held at ISATE, an international conference organized by the Organization of National Colleges of Technology in Japan in cooperation with several countries worldwide. This is a compilation of these papers into a reprint. Therefore, this is a wide-ranging collection of papers, including interdisciplinary fields, such as mechanical engineering, electrical and electronic engineering, industrial chemistry, bioengineering, civil and architectural engineering, and agriculture. Science and technology are becoming more critical than ever to create a better future and pass the baton to the next generation in a suitable manner. For this purpose, materials science and materials engineering, which are the foundation of all industries, will become increasingly necessary for their implementation in society. We hope that this Special Issue reprint will be of great help to those who are experimenting with such objectives.
    Keywords: oxide semiconductor ; electrodeposition ; photoluminescence ; focused X-ray ; imaging ; knowledge database ; scientific principles ; material property relationship ; network-type database ; interdisciplinary ; multidisciplinary ; graph search ; wide perspective ; lithium metal ; separator ; lithium-ion-conducting ceramics ; lithium battery ; lithium-oxygen battery ; antibacterial properties ; coating ; copper ; fine crevice structure ; super-spread wetting properties ; Sn–Bi-based alloy ; superplasticity ; tensile property ; deformation ; low-melting-point solder ; joining ; self-pierce riveting ; ultra-high strength steel sheets ; aluminum alloy sheets ; three sheets ; plastic deformation ; joint strength ; magnetic adsorbent ; synthesis methods ; material structure ; water treatment ; solar cell ; energy conversion ; organic–inorganic hybrid material ; Ti-alkoxide ; P3HT ; magneto-optical imaging ; nondestructive testing ; magnetic garnet ; spin coating method ; transmittance spectrum ; ZnAl2O4 (gahnite) ; low-temperature co-fired ceramics (LTCCs) ; solid-state-activated sintering ; microwave dielectric properties ; thermal conductivity ; ionic liquid ; double network gel ; one-pot synthesis ; tribology ; cohesive powder ; vertical vibration ; fluidization ; dispersion ; transportation ; silane coating ; silane compound ; biofilm formation ; acid permeation ; sewerage systems ; sewage ; contact angle ; adhesion work ; wettability ; powder metallurgy ; high-speed steel ; SKH57 ; hot isostatic pressing ; sintering ; magnetic resonance imaging (MRI) ; transmission electron microscopy (TEM) ; phase transition ; electrical resistivity ; metallic biomaterials ; Japanese cedar ; latewood ; mechanical property ; fracture surface observation ; plasterboard ; arsenic ; recycling ; on-site determination ; dry spinning ; silk fibroin ; ionic liquids ; cementite ; deformation texture ; neutron diffraction ; biofilms ; laboratory biofilm reactors ; LBR ; crystal violet ; optical reflection ; color analyses ; XYZ color plane ; L*a*b* color plane ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: The challenges in identifying effective therapies for CNS tumors continue to be daunting. Potentially effective targeted therapies must be able to penetrate the blood–brain barrier to reach the tumor and, in sufficient concentrations, to result in meaningful treatment responses. Moreover, molecular targets must be key drivers in the growth and progression of CNS tumors. Numerous potentially efficacious therapies have failed in randomized clinical trials due to other factors, including subclonal genetic intratumoral heterogeneity (particularly within malignant gliomas), epigenetic heterogeneity, and failure to target important factors involved in the tumor microenvironment. Developing effective targeted therapies requires a thorough fundamental understanding of the genetic and epigenetic factors driving tumor progression, the interactions between CNS tumor cells and the tumor microenvironment, and the key mechanisms of tumor treatment resistance. In this Special Issue, experts in the field of CNS tumors will highlight the most promising molecular targets in the development of treatments for patients with CNS tumors.
    Keywords: glioblastoma molecular classification ; ERK/MAPK pathway ; PI3K/PTEN pathway ; receptor tyrosine kinase ; EGFR ; PDGFRA ; FGFR3 ; MET ; EPHB2 ; NF1 ; immunotherapy ; glioblastoma ; blood–brain barrier ; central nervous system ; T cells ; T lymphocytes ; PCNSL ; CNS lymphoma ; methotrexate ; novel therapies ; novel therapeutics ; neurofibromatosis ; low grade glioma ; plexiform neurofibroma ; vestibular schwannoma ; glioma ; tumor mutation burden ; neoantigen ; immune score ; germline mutation ; antigen processing and presentation ; ependymoma ; subependymoma ; RELA ; YAP1 ; ZFTA ; PFA ; PFB ; MYCN ; Group A ; Group B ; myxopapillary ; targeted therapy ; diffuse midline gliomas ; molecular targets ; potential therapy development ; intraparenchymal metastases ; CNS disease ; metastatic disease ; tyrosine kinase inhibitors ; monoclonal antibodies ; Warburg effect ; mass spectrometry ; isotope labeling ; cancer metabolism ; pediatric brain tumor ; adenosine ; tumor microenvironment ; A2AAR antagonist ; immune evasion ; adenosine receptors ; bevacizumab ; temozolomide ; progression ; biomarker ; neoplastic ; meningitis ; leptomeningeal ; chemotherapy ; radiotherapy ; intrathecal ; GBM ; U87MG ; A172 ; Metformin ; LPS ; antioxidant ; cell cycle arrest ; apoptosis ; low-grade glioma ; preclinical models ; IDH-mutant glioma ; patient avatars ; methylation ; methylomics ; G-CIMP ; MGMT ; DNMT ; ATRX ; H3K27M ; CpG island ; tumor suppressor ; methyltransferases ; histone acetylation ; brain tumor ; brain metastasis ; lung cancer ; lung malignancy ; progression-free survival ; epidermal growth factor receptor ; lung carcinoma ; molecular therapy ; whole-brain radiation therapy ; stereotactic radiosurgery ; KIF11 ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 92
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Cybersecurity models include provisions for legitimate user and agent authentication, as well as algorithms for detecting external threats, such as intruders and malicious software. In particular, we can define a continuum of cybersecurity measures ranging from user identification to risk-based and multilevel authentication, complex application and network monitoring, and anomaly detection. We refer to this as the “anomaly detection continuum”. Machine learning and other artificial intelligence technologies can provide powerful tools for addressing such issues, but the robustness of the obtained models is often ignored or underestimated. On the one hand, AI-based algorithms can be replicated by malicious opponents, and attacks can be devised so that they will not be detected (evasion attacks). On the other hand, data and system contexts can be modified by attackers to influence the countermeasures obtained from machine learning and render them ineffective (active data poisoning). This Special Issue presents ten papers that can be grouped under five main topics: (1) Cyber–Physical Systems (CPSs), (2) Intrusion Detection, (3) Malware Analysis, (4) Access Control, and (5) Threat intelligence.AI is increasingly being used in cybersecurity, with three main directions of current research: (1) new areas of cybersecurity are being addressed, such as CPS security and threat intelligence; (2) more stable and consistent results are being presented, sometimes with surprising accuracy and effectiveness; and (3) the presence of an AI-aware adversary is recognized and analyzed, producing more robust solutions.
    Keywords: Internet of Things ; cybersecurity ; cyber threats ; malware detection ; machine learning ; network traffic ; cooperative intelligent transportation systems (cITSs) ; IDS ; vehicular ad-hoc networks (VANET) ; adaptive model ; deep belief network (DBN) ; NIDS ; deep learning ; false negative rate ; artificial neural network ; MITRE ATT&CK Matrix ; techniques classification ; BERT-based multi-labeling ; formal ontology ; risk identification ; vulnerability ; portable executable malware ; tree-based ensemble ; performance comparison ; statistical significance test ; adversarial examples ; face recognition ; mask matrix ; targeted attack ; non-targeted attack ; anomaly detection ; attack detection ; cyber-physical system ; datasets ; evaluation metrics ; biometric cryptosystem ; iris identification ; error-correcting codes ; intrusion detection ; smart grid ; neural networks ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Humans and animals are continuously exposed to different unwanted actions of compounds, including mycotoxins present in food, water, and air. The presence of mycotoxins is a reason for different disease states or tissue and organism dysfunction. New work should facilitate a more accurate description of the degree of species sensitivity and more efficient dietary management, using environmental influences to improve plant material and animal health quality during primary production. On the other hand, better knowledge of the different forms of enzymes participating in mycotoxin biotransformation would enable more efficient preventive and therapeutic actions in many disease states in which the aetiology was not fully understood until now.
    Keywords: zearalenone ; digestive tract ; carryover factor ; ERs mRNA ; CYP1A1 mRNA ; GSTP1 mRNA ; pre-pubertal gilts ; low doses ; carry-over ; myocardium ; vascular reactivity ; mastitis ; ovarian cysts ; pyometra ; hepatic portal system ; dairy cows ; biosensors ; deoxynivalenol ; immunosensors ; feed ; antibody ; aptamer ; molecularly imprinted polymer ; low dose ; bone marrow microenvironment ; haematology ; AMH ; cattle ; long-term monitoring ; sub-clinical contamination ; SAA ; urine ; intestines ; CYP1A1 and GSTπ1 ; prepubertal gilts ; amoxicillin ; doxycycline ; Ussing chamber ; swine jejunum mucosa explants ; gonads ; hypothalamus ; pituitary gland ; steroid hormones ; immunohistochemistry ; oestrogen receptors ; gilts before puberty ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: It was recently reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Human and industrial activities generate various forms of residual wastes and by-products in a solid, liquid, or gaseous state. Waste generation starts with simple processes such as living, eating, and breathing. Managing waste and minimizing associated environmental impacts have become more challenging as worldwide populations and economies continue to grow. Once these hazardous chemicals are present in the environment, people can become exposed to them. Human health can be influenced by many factors, including exposure to physical, chemical, biological, and radiological contaminants in the environment.This reprint comprises research papers related to the aspects of environmental exposure to multiple toxic chemicals and human health. The manuscripts are focused on toxicology, biomonitoring, exposure and risk assessment, and endocrine disruptors.
    Keywords: pesticide ; insecticide ; herbicide ; fungicide ; rheumatoid arthritis ; autoimmune disease ; n/a ; ovary ; endocrine disruptors ; follicular growth ; hormonal secretions ; gene expression ; bisphenols ; plasticiser ; ewe ; tetracyclines ; sulfonamides ; quinolones ; streptomycines ; meat ; antibiotics ; risk assessment ; air pollution ; endothelium ; inflammation ; cardiovascular disease ; ALS ; Alzheimer’s ; Aβ1–42 ; α synuclein ; children ; cerebrospinal fluid ; cisternal CSF ; fronto-temporal dementia ; Metropolitan Mexico City ; nanoparticles ; olfactory bulb granule cells ; PM2.5 ; Parkinson’s ; hyperphosphorylated tau ; TDP-43 ; cadmium ; crab ; crustaceans ; heavy metal toxicity ; nutrition ; pollution ; biomagnification ; biomonitoring ; benchmark dose ; BMDL ; BMDU ; creatinine clearance ; chronic kidney disease ; eGFR ; NOAEL ; urine cadmium ; plant protection products ; residential exposure ; agriculture ; Africa ; exposure pathway ; intake dose ; temporal variations ; spatial variations ; pollutants ; women exposure ; microRNAs ; PAHs ; paint production plant ; volatile organic compounds (VOCs) ; inhalation exposure ; cancer risk ; non-cancer risk ; economic loss ; subway PM exposure ; health burden ; long-term mortality ; morbidity ; 3-PBA ; pyrethroid pesticides ; pregnancy ; newborn ; anthropometry ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Special Issue is intended to lay the foundation of AI applications focusing on oral health, including general dentistry, periodontology, implantology, oral surgery, oral radiology, orthodontics, and prosthodontics, among others.
    Keywords: machine learning ; artificial intelligence ; malocclusion ; diagnostic imaging ; active learning ; maxillary sinusitis ; convolutional neural network ; deep learning ; segmentation ; oral microbiota ; LEfSe ; PCoA ; alloprevotella ; prevotella ; core microbiota ; artificial neural networks ; oral cancer diagnosis ; oral cancer prediction ; pit and fissure sealants ; caries assessment ; visual examination ; clinical evaluation ; convolutional neural networks ; transfer learning ; deep learning network ; YOLOv4 ; mandibular third molar ; inferior alveolar nerve ; contact relationship ; panoramic radiograph ; deep learning methods ; caries diagnosis ; dental panoramic images ; radiography ; Fourier transform infrared spectroscopy ; FTIR imaging ; spectral biomarker ; multivariate analysis ; discriminant model ; oral squamous cell carcinoma ; oral epithelial dysplasia ; oral potentially malignant disorder ; risk stratification ; early oral cancer detection ; dentigerous cysts ; histopathology images ; image classification ; odontogenic keratocysts ; radicular cysts ; AI ; screening ; diagnosis ; dentistry ; ultrasonography ; tongue ; algorithm ; dysphagia ; impacted ; tooth ; detection ; neural networks ; proximal caries ; training strategy ; small dataset ; periapical radiograph ; X-ray ; tooth extraction ; oroantral fistula ; operative planning ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint focuses on novel findings of diagnostic dermatopathology, such as diagnosable new morphological (histopathologic) findings, immunohistochemical and immunofluorescent markers, and molecular techniques. Dermatopathology is the most sophisticated area in anatomic pathology; we can easily observe superficial skin lesions using our eyes without the need for an invasive approach and can easily compare gross configurations to microscopic and immunohistochemical findings. Meanwhile, dermatopathology has recently focused on the study of various cutaneous diseases at the molecular biology level. Many cutaneous diseases are now being well-researched, and special attention is paid to keratoacanthoma, lichen sclerosus (et atrophicus), mycosis fungoides, atopic dermatitis, epidermolysis bullosa, extramammary Paget’s disease, malignant melanoma, psoriasis, and secondary neoplasms associated with nevus sebaceous.
    Keywords: extramammary Paget’s disease ; dermcidin ; prognosis ; lymph node metastasis ; survival ; mechanical intermittent compression ; malignant melanoma ; in vitro model ; cancer progression ; mycosis fungoides ; early stage ; diagnostic algorithm ; T-cell receptor rearrangement ; tumor-specific marker ; microRNA ; keratoacanthoma ; squamous cell carcinoma (SCC) ; keratoacanthoma-like SCC ; keratoacanthoma with malignant transformation ; crateriform neoplasms ; crateriform verruca ; crateriform seborrheic keratosis ; crateriform Bowen disease ; crateriform SCC arising from actinic keratosis ; crater form of infundibular SCC ; psoriasis ; STAT3 ; cancer ; immunohistochemistry ; atopic dermatitis ; biologic agents ; neuroimmune interactions ; type 2 inflammation ; PSORS1C3 ; PSORS1C1/CDSN ; LOC105375015 ; rs1062470 ; rs887466 ; rs10484554 ; single-nucleotide polymorphism ; epidermolysis bullosa ; mutation ; heterogeneity ; nevus sebaceus ; malignant tumor ; basal cell carcinoma ; sebaceus carcinoma ; lichen sclerosus ; extracellular matrix protein 1 ; lipoid proteinosis ; basement membrane zone ; laminin-332 ; collagen IV ; collagen VII ; glycosaminoglycan ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: This reprint collected a set of papers where our section Editorial Board Members discuss key topics that typify the very best insightful and influential original articles or reviews in the “Communications” field. We expect these papers to be widely read and highly influential within the field.
    Keywords: network security ; double defense ; zero trust ; situation awareness ; immunology ; blind modulation classification ; orthogonal frequency division multiplexing ; higher-order cumulant and cyclic cumulant ; maximum-likelihood ; maximum a posteriori ; deep learning ; convolutional neural networks ; probability of correct classification ; testbed implementation ; drone ; UAV ; RF methods ; software-defined radio ; detection system ; defense system ; TSN ; Industry 4.0 ; smart distributed measurement systems ; IIoT ; IoT ; Ethernet ; Wi-Fi ; bit error rate ; fading channels ; Internet of things ; LoRa ; performance evaluation ; Named Data Networking ; information centric networking ; caching ; edge networks ; 6G ; IEEE 802.11be ; multilink operation ; channel access ; backoff ; coexistence ; Bluetooth ; wireless passive human sensing ; wireless sensor networks ; cyber-attacks ; intrusion-detection system ; MCDM ; q-rung orthopair fuzzy sets ; q-ROFWG ; 5G ; 5G-AKA ; authentication ; blockchain ; BAN logic ; Scyther ; radio channel ; path loss ; signal strength ; receivers ; transmitters ; wireless communication ; computational modeling ; path planning ; electromagnetic propagation ; loss measurement ; propagation loss ; reconfigurable antenna ; metasurface ; varactor diode ; beam-scanning ; high gain ; actor–critic learning ; energy-efficiency ; O-RAN ; RAN optimization ; low power wide-area networks ; large-scale LoRa networks ; single-channel LoRa gateways ; multi-objective ; quantum computing ; quantum optimization algorithms ; quantum routing optimization ; 6G communication networks ; SNR estimation ; optical wireless communications ; intensity modulation ; digital signature ; elliptic curve cryptography ; key exchange ; platoons ; Sybil attack ; 3D indoor localization ; location-based services ; Internet of Things ; computer vision ; biomedical imaging ; biometrics ; remote sensing ; cybersecurity ; natural language processing ; audio and speech processing ; control system and robotics ; information system ; food ; agriculture ; chemistry ; characteristic mode ; parasitic loading ; slit loading ; low-profile ; wearable antenna ; platoon ; traffic congestion ; collision avoidance ; CACC ; merge maneuver ; join maneuver ; lane change ; clustering ; information element ; MAC de-randomization ; OPTICS ; probe request ; WiFi-enabled device detection ; wireless sensing device ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: Polypharmacy is a necessary and important aspect of drug treatment; however, it becomes a challenge when the medication risks outweigh the benefits for an individual patient. Drug–drug interactions and the introduction of prescribing cascades are common features of polypharmacy, which can lead to ineffectiveness and increased risk of adverse drug reactions (ADR). Genes encoding CYP450 isozymes and other drug-related biomarkers have attracted considerable attention as targets for pharmacogenetic (PGx) testing due to their impact on drug metabolism and response. This Special Issue is devoted to explore the status and initiatives taken to circumvent ineffectiveness and to improve medication safety for polypharmacy patients. Specific areas include drug–drug interactions and consequences thereof in therapeutic management, including PK- and PD-profiling; the application of PGx-based guidance and/or decision tools for drug–gene and drug–drug gene interactions; medication reviews; development and application of deprescribing tools; and drivers and barriers to overcome for successful implementation in the healthcare system.
    Keywords: acute kidney injury ; early biomarker ; plasma neutrophil gelatinase-associated lipocalin ; soluble urokinase plasminogen activator receptor ; medication optimization ; older patients ; emergency department ; multimorbidity ; polypharmacy ; potentially inappropriate medication use ; older adults ; prevalence ; determinants ; chronic ; outpatient ; 2019 Beers criteria ; Ethiopia ; pharmacogenomics ; persons with diabetes ; drug–drug interactions ; drug–gene interactions ; cytochrome P450 ; SLCO1B1 ; drug interaction checkers ; adverse drug reactions ; pharmacogenetics ; personalized medicine ; phenprocoumon ; DOACs ; bleeding ; thromboembolism ; HLA ; drug hypersensitivity ; abacavir ; allopurinol ; flucloxacillin ; antiepileptic drugs ; cost-effectiveness ; shared medication record ; medication reconciliation ; drug information service ; hospital pharmacy service ; electronic prescribing ; electronic medical record ; clinical pharmacist ; CYP2D6 ; CYP2D7P ; CYP2D8P ; copy number variation ; CNV ; genotyping ; 5’nuclease assay ; HRM ; high resolution melting ; drug metabolization ; extracellular vesicles ; exosomes ; microvesicles ; pharmacogene expression ; medication review ; deprescriptions ; quality of life ; aged ; 80 and over ; nursing homes ; deprescribing ; medication-based risk score ; health outcomes ; cytochromes ; CYP1A2 ; adverse drug reaction ; antipsychotics ; olanzapine ; clozapine ; loxapine ; children ; youth ; digital decision-support ; health services research ; general practice ; process evaluation ; antidepressants ; utility ; population-based ; appropriateness ; medication adherence ; digital health ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint contains fourteen chosen articles on robust design optimization of electrical machines and devices. Optimization is essential for the research and design of electromechanical devices, especially electrical machines. Finding optimal solutions may lead to cheaper and more efficient production of electrical machines. However, optimizing such a complex system as an electrical machine is a computationally expensive optimization problem, where many physical domains should be considered together. However, a good, practical design should be insensitive to parameter changes and the manufacturing tolerances. The collected papers show how modern artificial intelligence (AI) tools can be used for the robust design optimization of electric machines and electrical devices. The articles which are published in this Special Issue present the latest results of current research fields. Hopefully, the presented models and various application fields will provide useful information for researchers and professionals interested in these techniques themselves or who have other problems from different fields.
    Keywords: design optimization ; genetic algorithms ; Taguchi designs ; electromagnetic coupling ; additive manufacturing ; dynamic performance ; equivalent circuit model ; finite-element method ; linear induction motor ; longitudinal end effect ; transverse edge effect ; DLIM ; equivalent circuit ; end effect ; thrust ; finite element ; insulation core transformer ; non-uniformity of disk output voltage ; load regulation ; voltage compensation ; dummy primary winding ; PSO algorithm ; PMSM ; analytical method ; perturbation theory ; torque ; torque ripple ; rotor eccentricity ; optimization ; electrical machines ; finite element method ; nuclear power plant ; thermal degradation ; thermal-mechanical aging ; low-voltage cables ; polymer degradation ; dielectric spectroscopy ; hardness ; hairpin windings ; multi-objective optimizations ; Finite Element Method ; Lumped Parameter Model ; Permanent Magnet Synchronous Reluctance Motor ; rotor flux barrier ; torque development ; Aurivillius phases ; Bi3−xNdxTi1.5W0.5O9 ; activation energy Ea ; Curie temperature TC ; artificial intelligence ; optimization techniques ; self-organizing map ; power quality ; wind generation ; upgraded insulant ; ester oil-based nano fluids ; thermal conductivity ; relative viscosity ; nanoparticles effect ; alternative fluid ; temperature change ; model predictive control ; hysteresis current control ; execution time ; synchronous reluctance motors ; antenna array ; synthesis control ; quantized control ; array factor ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue includes 10 contributions centered on aquatic plants (and charophytes) in inland waters, with different approaches: floristic contributions and new reports of interesting or rare species, ecological studies on the use of macrophytes to characterize rivers and ponds, a genetic study to assess the diversity of an aquatic species within and among populations, the importance of herbaria in the study of a species, and finally a couple of interesting reviews on the use of hydrophytes and charophytes in wetland restoration.
    Keywords: charophyta ; Chara baueri ; species ecology ; species biogeography ; AFLP ; conservation ; genetic diversity ; river systems ; Stratiotes aloides ; wetland habitats ; revegetation ; submerged macrophytes ; floating macrophytes ; aquatic phanerogams ; charophytes ; seeding ; planting ; transplanting ; sediment transfer ; natural wetlands ; constructed wetlands ; lake management ; modelling ; carbon dioxide ; aquatic weeds ; respiration ; hypoxia ; Keddy Index ; submerged aquatic vegetation (SAV) ; Mediterranean flora ; aquatic flora ; carbon isotopes ; hydrophytes ; bioindicators ; inland waters ; water geochemistry ; Chara ; Nitella ; Tolypella ; Nitellopsis ; re-establishment ; nutrients ; herbivory ; Willdenowia ; Sardinia ; biogeography ; Chara zeylanica ; distribution ; ecology ; relic fern ; Mediterranean wetlands ; conservation status ; pteridophytes ; vegetation ; rice fields ; morphology ; haplostephanous species ; macrophytes ; lowland river ; long-term changes ; environmental parameters ; ecological status ; Slovenia ; aquatic plants ; wetlands ; alien invasive species ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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