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  • thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology  (1,259)
  • bic Book Industry Communication::M Medicine  (1,154)
  • thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general  (856)
  • bic Book Industry Communication::D Literature & literary studies
  • English  (3,148)
  • French  (340)
  • Portuguese  (197)
  • Chinese  (2)
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In recent years, the fascination with shape memory alloys (SMAs) has grown across industries such as aerospace, automotive, naval, civil, and biology. SMAs possess unique properties, including the ability to recover from deformation when heated, exhibit pseudoelastic stress-strain behavior for large deformations, and exceptional biocompatibility for bioengineering applications. However, a comprehensive understanding of critical characteristics like transformation temperature and stress values is necessary to fully utilize SMAs. The shape memory effect, where SMAs regain their original shape after deformation under specific thermal conditions, has driven innovative applications in various sectors. In aerospace, SMAs are used in wing structures and actuation systems, enabling morphing and improving aerodynamics. In healthcare, they are integrated into orthopedic devices, simplifying surgical procedures and providing necessary support. The automotive industry also benefits from SMAs, using them in seatbelts and vibration damping systems for enhanced safety and comfort. Accurate knowledge of critical characteristics is essential for effective utilization of SMAs, unlocking their potential in different fields. The remarkable versatility of SMAs, with their deformation recovery, pseudoelasticity, and biocompatibility, positions them as a material of immense interest. As research and development continue, SMAs are poised to drive future innovations, shaping various industries.
    Keywords: shape memory alloy (SMAs) ; shape memory effect (SME) ; superelasticity ; smart materials ; constitutive models ; simulation and modeling ; smart devices ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
    Language: English
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mg alloy is the lightest metallic structural material and possesses the advantages of high specific strength, high specific stiffness, good electromagnetism shield, good damping capacity, good machinability, and easy recycling, etc. Therefore, it has extremely broad application prospects and has drawn considerable interest in the fields of automobile, electronics, electrical appliances, transportation, aerospace, and aviation. In addition, Mg alloys are gradually showing application potential in emerging industries, serving as biodegradable metals in the biomedical field, functional material for hydrogen storage, and so on. This Special Issue (SI), entitled “Research Progress in High-Performance Magnesium Alloy and Its Applications”, presents recent developments and excellent results in the field of Mg alloys, and includes 10 articles and one editorial covering some interesting aspects of the topic.
    Keywords: grain refinement ; high strength and toughness ; {10–12} twin ; Mg-Gd-Y alloy ; multidirectional impact forging ; Mg-Zn-Mn-Ca ; Ca2Mg6Zn3 phase ; corrosion behaviors ; SKPFM ; boride ; MgB2 ; mechanical alloying ; ignition ; combustion ; flame temperature ; magnesium alloy ; biocompatibility ; surface coating modification ; corrosion resistance ; implantable bio-metal materials ; filler material ; welding ; scandium ; microstructure modification ; mechanical properties ; microstructure ; texture ; stretch formability ; high temperature cross-rolling ; annealing ; wire arc additive manufacturing ; cold metal transfer ; Al-Mg alloys ; orthogonal experiment ; Mg-Bi-Ca alloy ; hot deformation ; constitutive model ; dynamic recrystallization kinetics ; Mg alloy ; twinning ; random orientation ; compression ; room temperature ; backward extrusion ; tensile strength ; failure mechanism ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
    Language: English
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  • 6
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
    Publication Date: 2023-12-21
    Description: Um livro valioso, que analisa com clareza o papel fundamental dos recursos humanos para a saúde e o desenvolvimento, bem como o contexto e o impacto da reforma sanitária e a relação entre as iniciativas internacionais, nacionais e locais em prol da mudança dos serviços de saúde. Além de examinar os antecedentes e os principais atores da área de recursos humanos e explicar com detalhes as negociações que visavam transformar em prioridade nacional a formação de recursos humanos e a distribuição dos trabalhadores de saúde no território, Recursos Críticos está apoiado em uma sólida pesquisa bibliográfica, testemunhos fascinantes e análise original, que fazem da obra uma contribuição significativa no campo da memória da saúde pública e uma ferramenta indicativa de perspectivas de futuro para trabalhadores na área da saúde. É uma pesquisa histórica de grande qualidade, voltada para a análise da cooperação Opas-Brasil, e um incentivo à realização de novos estudos sobre as interfaces entre a atuação de agências internacionais e os interesses nacionais, partindo do conceito de arenas ou espaços de negociação.
    Keywords: R5-920 ; Brasil ; Recursos humanos em saúde ; Planos e programas de saúde ; Cooperação técnica ; Organização Pan-Americana da Saúde ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Metalliferous minerals play a central role in the global economy. They will continue to provide the raw materials we need for industrial processes. Significant challenges will likely emerge if the climate-driven green and low-carbon development transition of metalliferous mineral exploitation is not managed responsibly and sustainably. Green low-carbon technology is vital to promote the development of metalliferous mineral resources shifting from extensive and destructive mining to clean and energy-saving mining in future decades. Global mining scientists and engineers have conducted a lot of research in related fields, such as green mining, ecological mining, energy-saving mining, and mining solid waste recycling, and have achieved a great deal of innovative progress and achievements. This Special Issue intends to collect the latest developments in the green low-carbon mining field, written by well-known researchers who have contributed to the innovation of new technologies, process optimization methods, or energy-saving techniques in metalliferous minerals development.
    Keywords: metallurgical slag-based binders ; solidification/stabilisation ; As(III) ; As(V) ; calcium hydroxide ; sublevel caving ; numerical simulation ; physical model ; structural parameter ; green mining ; limestone ; high temperature ; confining pressure ; SHPB ; constitutive model ; open-pit mine ; PLAXIS 3D ; dynamic load ; safety factor ; acceleration ; particle sedimentation ; filling mining ; degree of influence ; pipeline transportation ; solid waste utilization ; tailings ; reclamation risk ; hazard identification ; complex network ; hazard management ; digital mine ; mine short-term production planning ; haulage equipment dispatch plan ; ABCA ; NSGA ; settlement velocity measurement ; K-means ; tailings backfill ; unsupervised learning ; cemented paste backfill ; ESEM ; picture processing ; floc networks ; pumping agent ; fractal dimension ; backfill slurry ; strength of cemented backfill ; inhomogeneity of cemented backfill ; cemented tailings backfill ; copper ; zinc ; recovery ; sulfide concentrate ; artificial microbial community ; granular backfill ; bearing characteristics ; numerical model ; particle size ; surface subsidence ; blasting dust movement ; dust concentration ; particle size distribution ; blasting dust reduction ; backfill ; metal mine ; log-sigmoid ; tailings pond ; regional distribution ; dam break ; accident statistics ; causation analysis ; backfilling ; increasing resistance and reducing pressure ; computational fluid dynamics ; spiral pipe ; stowing gradient ; coal-based solid waste ; orthogonal experiment ; strength development ; regression analysis ; engineering performance ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTU Mining technology and engineering
    Language: English
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  • 9
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 10
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders;celiac disease;gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Elastomer materials are characterized by their high elongation and (entropy) elasticity, which makes them indispensable for widespread applications in various engineering and medical areas as well as consumer goods. This book focuses on the state-of-the-art of elastomers covering all aspects from their properties to applications. The development and testing of advanced elastomers is of particular interest. Attention is given to various aspects of elastomers, such as ever-increasing environmental concepts dealing with recyclability and reusability, incorporation of functional groups or additives to obtain novel functionality or bioelastomers, analytical description of mechanisms and structure relations of the fracture behavior of elastomers, and their external stimuli-responsive character. The scope of the book encompasses contributions at the frontier of science in polymer network synthesis, experimental and theoretical physics of polymer networks, and new structures and functionalities incorporated into elastomers leading to enhanced properties of crosslinked elastomeric materials, among others.
    Keywords: magnetorheological elastomer ; filler ; hetero-aggregation ; nanosized Ni-Mg cobalt ferrites ; electrical resistance ; resistivity ; rheological properties ; elastomers ; in-situ silica ; friction ; abrasion ; tear fatigue test ; buffing dust collagen (BDC) ; styrene–butadiene rubber (SBR) ; polymer composites ; biodegradation ; bio-oil ; bio-based plasticizer ; eco-friendly plasticizer ; acrylonitrile-butadiene rubber ; NBR ; mechanical testing ; thermo-oxidative aging ; vulcanized rubber ; rubber compounds ; carbon black ; vibration damping ; viscoelasticity ; magnetorheological ; elastomer ; magnetic particle ; viscoelastic ; rheological ; smart materials ; coating ; particle coating ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In this Special Issue, we have several papers related to fuel-cell-based cogeneration systems; the management and control of fuel cell systems; the analysis, simulation, and operation of different types of fuel cells; modelling and online experimental validation; and the environment assessment of cathode materials in lithium-ion battery energy generation systems. A paper which gives a comprehensive review with technical guidelines for the design and operation of fuel cells, especially in a cogeneration system setup, which can be an important source of references for the optimal design and operation of various types of fuel cells in cogeneration systems, can also be found in this Special Issue.
    Keywords: LIBs ; environmental sustainability ; cathode material ; LCA ; wind energy ; fuel cell ; IM ; induction generator ; hybrid system ; mine blast optimizer ; solid oxide fuel cell ; robust model predictive control ; off-line calculation ; control synthesis ; review ; cogeneration ; optimal design ; guidelines ; SOFC ; simulation ; internal reforming ; anode oxidation ; carbon formation ; direct methanol fuel cell ; methanol crossover ; power density ; catalyst ; membrane electrode assembly ; Colebrook equation ; fuel cells ; flow friction factor ; open-cathode ; pressure drop ; symbolic regression ; numerically stabile solution ; roughness ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 15
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Smart materials and structures are capable of active or passive changes in terms of shapes, properties, and mechanical or electromagnetic responses in reaction to an external stimulus, such as light, temperature, stress, moisture, pH, and electric or magnetic fields. They have attracted increasing interest for their enhanced performance and efficiency over a wide range of industrial applications, especially for aerospace. These require novel engineering approaches and design philosophies in order to integrate the actions of sensors, actuators, and control circuit elements into a single system that can respond adaptively to its surroundings. This reprint has collected cutting-edge research and recent advances in smart materials and structures, including seven original research papers and three review articles, co-authored by 65 scientists and engineers from 18 institutions and 3 industries. The research topics mainly cover advanced materials, applications of smart materials and structures, as well as recent development in sensing techniques. We hope this reprint will contribute to disseminating the latest progress in smart materials and structures, as well as stimulate the interest of its audience to work in this important and vibrant area to promote and benefit the multidisciplinary scientific communities.
    Keywords: textile-based mechanical sensors ; mechanism ; preparation ; advantages ; applications ; Artificial Neural Network (ANN) ; guided waves ; Structural Health Monitoring (SHM) ; Finite Element Analysis (FEA) ; damage detection ; metals ; composites ; aeroelastic stability ; bladed disk ; intentional mistuning ; piezoelectric material ; topological optimization ; microstructure ; high-entropy alloy ; mechanical property ; bipedal robot ; dynamics simulation ; MRE isolator ; vibration reduction control algorithms ; no-core fiber ; polyaniline ; polyacrylic acid ; pH sensor ; multimode interference ; gas foil bearing ; Inconel alloy ; sensing foil ; strain field ; temperature field ; thermomechanical coupling ; thermomechanical characterization ; rotor dynamics ; turbomachinery ; cholesteric liquid crystals ; electro-optic response ; polymer stabilization ; ion-trapping mechanism ; liquid metal ; stretchable conductor ; 3D printing ; high dynamic stability ; wearable devices ; biomimetic ; Venus flytrap ; smart ; composite ; mechanics ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Non-Newtonian (non-linear) fluids are common in nature, for example, in mud and honey, but also in many chemical, biological, food, pharmaceutical, and personal care processing industries. This Special Issue of Fluids is dedicated to the recent advances in the mathematical and physical modeling of non-linear fluids with industrial applications, especially those concerned with CFD studies. These fluids include traditional non-Newtonian fluid models, electro- or magneto-rheological fluids, granular materials, slurries, drilling fluids, polymers, blood and other biofluids, mixtures of fluids and particles, etc.
    Keywords: TA1-2040 ; T1-995 ; Poiseuille–Couette flow ; membrane ; viscous fluid ; channel flow ; existence theorem ; yield stress ; hemoglobe capacitor ; creeping flows ; viscoplastic fluids ; projection method ; power-law fluid ; first- and second-order slip ; Mittag–Leffler ; lubrication ; viscoplastic fluid ; rupture ; convection ; Re numbers ; enhanced oil recovery (EOR) ; SPH-FEM ; Gamma densitometer ; oil recovery ; non-newtonian fluids ; marginal function ; particle interaction ; computational fluid dynamics ; non-isothermal flows ; suspensions ; Brinkman equation ; lubrication approximation (76A05 ; lid-driven cavity ; smoothed particle hydrodynamics (SPH) ; 76D08 ; Phan-Thien–Tanner (PTT) model ; bubble suspension ; porous media ; non-equilibrium thermodynamics ; porous medium ; suspension viscosity ; hemoglobin ; convection-diffusion ; slug translational velocity ; closure relationship ; non-linear fluids ; wormlike micellar solutions (WMS) ; high viscosity oil ; viscoelastic surfactants (VES) ; 76A20) ; meshless ; Bingham fluid ; Reynolds equation ; generalised simplified PTT ; dense suspension ; chemical EOR (cEOR) ; buoyancy force ; viscosity ratio ; aspect ratio ; rheology ; lubrication approximation ; fluid-solid interaction (FSI) ; optimal control ; natural convection ; biofluids ; shear-dependent viscosity ; thermodynamic capacitor ; shear-thinning ; stokesian dynamics ; weak solution ; biological capacitor ; cement ; variable viscosity ; Couette flow ; pressure boundary conditions ; inhomogeneous fluids ; boundary control ; similarity transformation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The development of solid state gas sensors based on microtransducers and nanostructured sensing materials is the key point in the design of portable measurement systems able to reach sensing and identification performance comparable with analytical ones. In such a context several efforts must be spent of course in the development of the sensing material, but also in the choice of the transducer mechanism and its structure, in the electrical characterization of the performance and in the design of suitable measurement setups. This call for papers invites researchers worldwide to report about their novel results on the most recent advances and overview in design and measurements for applications in gas sensors, along with their relevant features and technological aspects. Original research papers are welcome (but not limited) on all aspects that focus on the most recent advances in: (i) basic principles and modeling of gas and VOCs sensors; (ii) new gas sensor principles and technologies; (iii) Characterization and measurements methodologies; (iv) transduction and sampling systems; (vi) package optimization; (vi) gas sensor based systems and applications.
    Keywords: TA1-2040 ; T1-995 ; indium oxide ; n/a ; environmental monitoring ; semiconductor ; gas sensor ; packed gas chromatographic column ; ultrathin carbon layer ; metal-oxide-semiconductor array sensor ; halitosis ; laser ablation ; capacitive micromachined ultrasonic transducers (CMUT) ; LTCC side via ; MEMS ; indirect packaging ; gas sensing ; efficiency ; bad breath ; electrospray ; array optimization ; low temperature co-fired ceramic (LTCC) ; electronic nose ; UV irradiation ; core/shell nanostructure ; combinatorial and high-throughput technique ; sensitive material ; hydrogen sulfide ; CO detection ; ZnO ; amperometric ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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  • 20
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The use of concentrated solar technologies has grown significantly worldwide in the last decade but the research and development of this renewable energy technology still needs to be advanced to guarantee its competitiveness with other energy sources. Challenges remain with reducing costs, optimizing the systems design, and increasing the performance and durability of the systems.This Special Issue on research on solar collectors presents some recent developments and studies on tracking-solar collectors for medium- to high-temperature applications, both line- and point-focus systems, conceived for the supply of heat in industrial processes, to provide thermal energy to a power block for electricity production, or even to combine heat and electricity generation in a solar collector unit (CPV/T). The articles included in this Special Issue cover theoretical or practical issues on geometrics optics, thermal–hydraulic modelling, and performance analysis, focusing on the following topics:• Solar towers: heliostat fields analysis and optimization• Solar towers: heat transfer media studies• Parabolic troughs: evacuated solar receivers analysis and thermal–hydraulic modelling• Fresnel reflectors: geometrics optics and manufacturing issues• Fresnel lens in CPV• Energy losses in solar collectors systems
    Keywords: thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Concerns relating to energy supply and climate change have driven renewable energy targets around the world. Marine renewable energy could make a significant contribution to reducing greenhouse gas emissions and mitigating the consequences of climate change, while providing a high-technology industry. The conversion of wave and tidal energy into electricity has many advantages. Individual tidal and wave energy devices have been installed and proven, with commercial arrays planned throughout the world. The wave and tidal energy industry has developed rapidly in the past few years; therefore, it seems timely to review current research and map future challenges. Methods to improve understanding of the resource and interactions (between energy extraction, the resource and the environment) are considered, such as resource characterisation (including electricity output), design considerations (e.g., extreme and fatigue loadings) and environmental impacts, at all timescales (ranging from turbulence to decadal) and all spatial scales (from device and array scales to shelf sea scales).
    Keywords: tide-surge-wave model ; Taiwanese waters ; sea-state hindcast ; wave power ; wave energy ; unstructured grid model ; resource characterization ; WaveWatch III ; SWAN ; tidal energy ; experimental testing ; acoustic Doppler profiler ; Strangford Lough ; dc-dc bidirectional converter ; finite control set-model predictive control (FCS-MPC) ; oscillating water column (OWC) ; supercapacitor energy storage (SCES) ; wave climate variability ; wavelet analysis ; teleconnection patterns ; marine renewable energy ; ocean energy ; environmental effects ; wave modeling ; wave propagation ; numerical modeling ; sediment dynamics ; risk assessment ; marine current energy ; spiral involute blade ; hydrodynamic analysis ; numerical simulation ; wave energy trends ; reanalysis wave data ; Chilean coast ; renewable energy ; wave energy converters ; annual mean power production ; wave energy converter ; transmission coefficient ; absorption ; surfing amenity ; resource ; impact assessment ; feasibility study ; floating offshore wave farm ; WEC ; IRR ; LCOE ; marine energy ; unmanned ocean device ; multi-type floating bodies ; nonlinear Froude-Krylov force ; energy efficiency ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 23
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Processing and storage can cause changes and interactions in food components that have effects on nutritional value, organoleptic characteristics or even food safety. This book includes 19 research works showing important and interesting advances, as well as new approaches, in this research topic. Four articles are dedicated to studying the effect of canning conditions (filling media and some ingredients) on the diverse parameters of quality for fish and pet foods. Three articles are devoted to studying the effects of dehydration (pre-treatments and drying procedures). One article is dedicated to monitoring the elaboration of a fermented and dehydrated product (sausage) using a portable NIRS device. The ninth article of this book studies the effect of low-dose electron beam irradiation on cooking quality, moisture migration, and thermodynamics, as well as the digestion properties of the isolated starches in newly harvested and dried rice. The next contribution studies the use of different preservatives to avoid the formation of undesirable volatile organic compounds in stracciatella cheese. Another article examines the impact of source material, kibble size, temperature, and duration on the efficiency of the aqueous extraction of sugars and phenolics from carob kibbles by conventional heat-assisted (HAE) and ultrasound-assisted (UAE) methods. In two articles, marinating with different extracts, alone or combined with other seasoning/conditioning methods, was essayed to tenderize beef or to improve the sensory quality of chicken leg and breast meat. The effect of various cooking methods on the quality, structure, pasting, water distribution and protein oxidation of fish and meat-based snacks is studied in the fourteenth article. The last five articles are dedicated to the study of the effects of storage on several foods (olive oil, blueberry, beetroot and Atlantic mackerel).
    Keywords: Electron Beam Irradiation ; rice ; moisture ; physicochemical properties ; rabbiteye blueberry ; postharvest storage ; firmness ; aroma compounds ; off-odor ; dry-fermented sausages ; near infrared spectroscopy ; portable device ; PLS-DA ; Scomber colias ; prior chilling ; Fucus spiralis ; packaging medium ; canning ; lipid damage ; colour ; trimethylamine ; quality ; carob kibbles ; carob juice ; aqueous extraction ; sugars ; phenolics ; free amino acids ; biogenic amines ; filling medium ; European eels ; stracciatella cheese ; volatile organic compounds ; sensory characteristics ; natural preservatives ; cheese storage ; pineapple by-products ; hydrostatic pressure ; bromelain ; enzyme activity ; marinade ; meat ; texture ; water status and distribution ; microstructure ; secondary structure of protein ; Atlantic mackerel ; saffron quality ; secondary metabolites ; drying ; high performance liquid chromatography-diode array detection (HPLC-DAD) ; spectrophotometry ; canned eels ; olive oil ; sunflower oil ; oxidation ; antioxidants ; total phenols ; vitamin E ; fresh wet noodles ; humidity-controlled dehydration ; microorganisms ; shelf-life ; noodle quality ; “Rocha” pear ; ultrasound ; microwave ; quality characteristics ; empirical models ; beetroot ; organic farming ; storage ; bioactive compounds ; betalain ; nitrate ; sugar ; phenolic compounds ; total dry matter ; chicken meat ; sensory evaluation ; superheated steam ; marination ; hot smoking ; storage effect ; extra virgin olive oil ; phenols ; sterols ; tocopherols ; temperature ; argon ; freeze-thaw cycles ; anthocyanins ; gas chromatography-mass spectrometry ; aroma profiles ; hot-air drying ; blueberry ; cooking methods ; fish meat snacks ; LF-NMR ; SEM ; protein oxidation ; expressible moisture ; gel ; gum ; heat penetration ; thermally processed ; wet pet food ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 24
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue was intended as a forum to advance research and apply machine-learning and data-mining methods to facilitate the development of modern electric power systems, grids and devices, and smart grids and protection devices, as well as to develop tools for more accurate and efficient power system analysis. Conventional signal processing is no longer adequate to extract all the relevant information from distorted signals through filtering, estimation, and detection to facilitate decision-making and control actions. Machine learning algorithms, optimization techniques and efficient numerical algorithms, distributed signal processing, machine learning, data-mining statistical signal detection, and estimation may help to solve contemporary challenges in modern power systems. The increased use of digital information and control technology can improve the grid’s reliability, security, and efficiency; the dynamic optimization of grid operations; demand response; the incorporation of demand-side resources and integration of energy-efficient resources; distribution automation; and the integration of smart appliances and consumer devices. Signal processing offers the tools needed to convert measurement data to information, and to transform information into actionable intelligence. This Special Issue includes fifteen articles, authored by international research teams from several countries.
    Keywords: virtual power plant (VPP) ; power quality (PQ) ; global index ; distributed energy resources (DER) ; energy storage systems (ESS) ; power systems ; long-term assessment ; battery energy storage systems (BESS) ; smart grids ; conducted disturbances ; power quality ; supraharmonics ; 2–150 kHz ; Power Line Communications (PLC) ; intentional emission ; non-intentional emission ; mains signalling ; virtual power plant ; data mining ; clustering ; distributed energy resources ; energy storage systems ; short term conditions ; cluster analysis (CA) ; nonlinear loads ; harmonics, cancellation, and attenuation of harmonics ; waveform distortion ; THDi ; low-voltage networks ; optimization techniques ; different batteries ; off-grid microgrid ; integrated renewable energy system ; cluster analysis ; K-means ; agglomerative ; ANFIS ; fuzzy logic ; induction generator ; MPPT ; neural network ; renewable energy ; variable speed WECS ; wind energy conversion system ; wind energy ; frequency estimation ; spectrum interpolation ; power network disturbances ; COVID-19 ; time-varying reproduction number ; social distancing ; load profile ; demographic characteristic ; household energy consumption ; demand-side management ; energy management ; time series ; Hidden Markov Model ; short-term forecast ; sparse signal decomposition ; supervised dictionary learning ; dictionary impulsion ; singular value decomposition ; discrete cosine transform ; discrete Haar transform ; discrete wavelet transform ; transient stability assessment ; home energy management ; binary-coded genetic algorithms ; optimal power scheduling ; demand response ; Data Injection Attack ; machine learning ; critical infrastructure ; smart grid ; water treatment plant ; power system ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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  • 25
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This book is motivated by our passion to compile recent research on antimicrobial surfaces. We aimed to assemble research papers on the preparation of new materials, antimicrobial testing using different pathogens (bacteria, fungi, and viruses), and the relationship between the coating nanostructure and its reactivity towards the studied pathogen(s). We believe that a good antimicrobial coating should by characterized by (i) a fast activity towards the pathogen, (ii) sustainable activity based on the stability of the coating, and (iii) the lowest possible toxicity for humans and reduced risks for the environment. Striking a compromise between these different challenges is difficult and requires more research.
    Keywords: active packaging ; chitosan ; methylcellulose ; natamycin ; antimicrobial action ; quaternary ammonium groups ; acrylic acid ; glycidyl methacrylate ; crosslinking reaction ; coating ; edible films ; edible coatings ; antimicrobial agents ; fresh fish ; spoilage ; shelf-life ; black anther disease ; orchid cut flower ; silver nanoparticles ; antifouling efficacy ; flow-through ; triangular box ; Amphibalanus amphitrite ; cuprous oxide ; dynamic aging ; repellant activity ; raft experiment ; bioassay ; biofouling of ships’ hull ; polypropylene ; hernia meshes ; antibacterial ; drug release ; polydopamine ; antimicrobial ; citric acid ; cross-linked ; cold plasma ; antimicrobial activity ; brilliant green ; crystal violet ; demethylation ; lignin ; polyurethane coatings ; triphenylmethane dyes ; 3D printing ; catheters ; dialysis ; extrusion ; infections ; manufacturing ; infection ; coatings ; silver ; nanomaterials ; plasma deposition ; titanium-based thin films ; copper ; magnetron sputtering ; super-elastic coatings ; E. coli inactivation ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
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  • 26
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The Special Issue “Assessment and Nonlinear Modeling of Wave, Tidal, and Wind Energy Converters and Turbines” contributes original research to stimulate the continuing progress of the offshore renewable energy (ORE) field, with a focus on state-of-the-art numerical approaches developed for the design and analysis of ORE devices. Particularly, this collection provides new methodologies, analytical/numerical tools, and theoretical methods that deal with engineering problems in the ORE field of wave, wind, and current structures. This Special Issue covers a wide range of multidisciplinary aspects, such as the 1) study of generalized interaction wake model systems with elm variation for offshore wind farms; 2) a flower pollination method based on global maximum power point tracking strategy for point-absorbing type wave energy converters; 3) performance optimization of a Kirsten–Boeing turbine using a metamodel based on neural networks coupled with CFD; 4) proposal of a novel semi-submersible floating wind turbine platform composed of inclined columns and multi-segmented mooring lines; 5) reduction of tower fatigue through blade back twist and active pitch-to-stall control strategy for a semi-submersible floating offshore wind turbine; 6) assessment of primary energy conversion of a closed-circuit OWC wave energy converter; 7) development and validation of a wave-to-wire model for two types of OWC wave energy converters; 8) assessment of a hydrokinetic energy converter based on vortex-induced angular oscillations of a cylinder; 9) application of wave-turbulence decomposition methods on a tidal energy site assessment; 10) parametric study for an oscillating water column wave energy conversion system installed on a breakwater; 11) optimal dimensions of a semisubmersible floating platform for a 10 MW wind turbine; 12) fatigue life assessment for power cables floating in offshore wind turbines.
    Keywords: off-shore wind farms (OSWFs) ; wake model ; wind turbine (WT) ; Extreme Learning Machine (ELM) ; wind power (WP) ; large-eddy simulation (LES) ; point-absorbing ; wave energy converter (WEC) ; maximum power point tracking (MPPT) ; flower pollination algorithm (FPA) ; power take-off (PTO) ; hill-climbing method ; Kirsten–Boeing ; vertical axis turbine ; optimization ; neural nets ; Tensorflow ; ANSYS CFX ; metamodeling ; FOWT ; multi-segmented mooring line ; inclined columns ; semi-submersible ; AFWT ; floating offshore wind turbine (FOWT) ; pitch-to-stall ; blade back twist ; tower fore–aft moments ; negative damping ; blade flapwise moment ; tower axial fatigue life ; wave energy ; oscillating water column ; tank testing ; valves ; air compressibility ; air turbine ; wave-to-wire model ; energy harnessing ; energy converter ; flow-induced oscillations ; vortex-induced vibration ; flow–structure interaction ; hydrodynamics ; vortex shedding ; cylinder wake ; tidal energy ; site assessment ; wave-current interaction ; turbulence ; integral length scales ; wave-turbulence decomposition ; OWC ; wave power converting system ; parametric study ; caisson breakwater application ; floating offshore wind turbines ; frequency domain model ; semisubmersible platform ; 10 MW wind turbines ; large floating platform ; platform optimization ; wind energy ; floating offshore wind turbine ; dynamic analysis ; fatigue life assessment ; flexible power cables ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 28
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Anthropogenic and natural disturbances to freshwater quantity and quality are a greater issue for society than ever before. To successfully restore water resources requires understanding the interactions between hydrology, climate, land use, water quality, ecology, and social and economic pressures. This Special Issue of Water includes cutting edge research broadly addressing investigative areas related to experimental study designs and modeling, freshwater pollutants of concern, and human dimensions of water use and management. Results demonstrate the immense, globally transferable value of the experimental watershed approach, the relevance and critical importance of current integrated studies of pollutants of concern, and the imperative to include human sociological and economic processes in water resources investigations. In spite of the latest progress, as demonstrated in this Special Issue, managers remain insufficiently informed to make the best water resource decisions amidst combined influences of land use change, rapid ongoing human population growth, and changing environmental conditions. There is, thus, a persistent need for further advancements in integrated and interdisciplinary research to improve the scientific understanding, management, and future sustainability of water resources.
    Keywords: physical habitat ; aquatic ecology ; stream health ; environmental flows ; land use ; hydrology ; hydroecology ; ecohydrology ; climate change ; Appalachia ; reforestation ; land use-land cover ; land-atmosphere coupling ; water quality ; environmental perceptions ; human dimensions ; spatial models ; socioeconomics ; urban watershed management ; municipal watershed ; water quality impairment ; collaborative adaptive management ; water resources ; urban watersheds ; endocrine disrupting chemical ; opioid ; pathway analysis ; ontology ; metabolomics ; decision-making ; logit regression ; farmer perceptions ; social networks ; public funds ; water conservation adoption ; good governance ; sanitation ; sustainability ; water supply ; water-saving agriculture ; Chinese provincial input efficiency ; three-stage DEA model ; environmental variables ; Boufakrane river watershed ; remote sensing ; LULCC ; water balances ; vulnerability ; total dissolved solids ; drinking water ; Appalachian Mountains ; streamflow sensitivity ; water security ; water balance partitioning ; Budyko ; Escherichia coli ; Suspended particulate matter ; Water quality ; Land use practices ; Watershed management ; basin ; hydrologic model ; reaeration rates ; stream metabolism ; watershed ; physicochemistry ; land use practices ; experimental watershed ; suspended particulate matter ; stream water temperature ; watershed management ; bacteria ; land-use practices ; environmental persistence ; saturated hydraulic conductivity ; pedotransfer function ; model validation ; Chesapeake Bay Watershed ; experimental watershed study ; human dimensions of water ; watershed modeling ; hydrological modeling ; water pollutants ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    Publication Date: 2024-03-27
    Description: This Special Issue provides an insight, collated from 26 articles, focusing on various aspects of the Fit-For-Purpose Land Administration (FFPLA) concept and its application. It presents some influential and innovative trends and recommendations for designing, implementing, maintaining and further developing Fit-For-Purpose solutions for providing secure land rights at scale. The first group of 14 articles is published in Volume One and discusses various conceptual innovations related to spatial, legal and institutional aspects and its wider applications within land use management. The second group of 12 articles is published in Volume Two and focuses on case studies from various countries throughout the world, providing evidence and lessons learned from the FFPLA implementation process.
    Keywords: complete cadastre ; legal element ; fixing boundary ; eligible landowner ; agreement ; boundary marker ; fit-for-purpose land administration (FFP LA) ; violent conflict ; United Nations ; extra-legal ; transitional justice ; peace building ; land governance ; power relations ; securing land rights ; land registration ; development impacts ; fit-for-purpose land administration ; land administration ; decentralization ; India ; fit-for-purpose ; institutions ; governance ; politics ; Amazon ; deforestation ; Fit-For-Purpose land administration ; participatory mapping ; indigenous land conflict ; Cumaribo ; Colombia ; community-based land adjudication ; components of adjudication ; land tenure ; land rights ; good practices ; updating land records ; systematic land registration ; unconventional approach ; case study ; Benin ; cadaster ; land administration domain model ; LADM ; cadastre ; FFPLA ; customary tenure ; land inventory ; land management ; mobile-based applications ; pro-poor ; land surveying ; tenure security ; land rights and tenure ; fit-for-purpose approach ; human rights ; design science research ; design thinking ; fit for purpose ; spatial data quality ; spatial data quality assurance ; maintenance ; update ; upgrade ; upkeep ; renewal ; data quality ; spatial framework ; STDM ; technology ; UAV ; feature extraction ; rapid urbanization ; climate change ; pandemic ; urban resilience ; spatial ; legal ; and institutional frameworks ; land tenure security ; pro-poor land recordation ; land governance reform ; cost effectiveness ; innovative technology ; case studies ; Uganda ; customary land tenure ; land recordation tools ; semantic technologies ; land information system ; fit-for-purpose land management ; aerial and street level imagery ; machine learning ; integrated land programs ; land policy ; pilot study ; informal settlements ; urban development ; Brazil ; community-based crowdsourcing ; SiGIT ; Ecuador ; land and resources rights ; public-private partnerships ; corporate social responsibility ; poverty reduction ; business driven solutions ; social enterprises ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The fundamentals of mechanical system dynamics were established before the beginning of the industrial era. The 18th century was a very important time for science and was characterized by the development of classical mechanics. This development progressed in the 19th century, and new, important applications related to industrialization were found and studied. The development of computers in the 20th century revolutionized mechanical system dynamics owing to the development of numerical simulation. We are now in the presence of the fourth industrial revolution. Mechanical systems are increasingly integrated with electrical, fluidic, and electronic systems, and the industrial environment has become characterized by the cyber-physical systems of industry 4.0. Within this framework, the status-of-the-art has become represented by integrated mechanical systems and supported by accurate dynamic models able to predict their dynamic behavior. Therefore, mechanical systems dynamics will play a central role in forthcoming years. This Special Issue aims to disseminate the latest research findings and ideas in the field of mechanical systems dynamics, with particular emphasis on novel trends and applications.
    Keywords: tire model ; tire temperature ; FSAE vehicle ; rolling bearing ; rigid rotor ; internal radial clearance ; number of rolling elements ; vibration ; varying compliance vibration ; ball passage frequency ; load ; trucks ; handling stability ; lightweight ; taper-leaf spring ; suspension ; step steer ; motorcycle tires ; thermal modeling ; performance optimization ; real-time simulations ; conveyor ; friction ; rolling ; non-linear simulation ; fractal derivative ; viscoelastic models ; polymers ; bicycle ; mountain bike ; tire tread pattern ; force and moment ; e-bike ; tyre ; dynamics ; active rear axle independent steering (ARIS) system ; hierarchical synchronization control ; virtual coupling control ; linear active disturbance rejection control (LADRC) ; computational fluid dynamics ; fluid sloshing ; table cart method ; zero moment point ; rider ; body segment inertial parameters ; biomechanics ; human body ; motorcycle ; multibody ; robot ; compliance ; machining ; modes of vibration ; impulsive testing ; dynamic parameter identification ; dynamic parameters ; parallel kinematics ; parallel robot ; parallel manipulator ; varying friction ; valve train ; coupled approach ; NVH ; vibration energy control ; multi-physics mechanism theory ; non-linear stiffness ; isolation ; hydraulic system ; magnetic spring ; articulated vehicle ; hydraulic steering system ; directional stability ; deformable soil ; tracked vehicle ; contact model ; two-wheeler ; vehicle dynamic modelling ; wobble ; weave ; fork bending compliance ; rider influence ; ADAS ; driver model ; load cell ; steering wheel ; cable robots ; motion planning ; cable failure ; recovery strategy ; roller chain ; chain efficiency ; sliding friction ; lateral offset ; damping force ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Supply Chain 4.0 is designed, planned, managed and optimized using Industry 4.0 technologies. There are many research issues and challenges associated with Supply Chain 4.0, a data rich complex system. The available data can interpret what happened in the past, what is currently happening, what will happen in the future and what are the best actionable decisions. Digitalization, visibility, connectivity and interoperability are integrated in Supply Chain 4.0. The operational, tactical and strategic plans across the supply chain are digitally interlinked and real-time synchronized with a 360-degree view. The win–win partnerships are dynamic and sustainable, with agility, flexibility and responsiveness to uncertain business environments. New models and methods are advocated to implement Supply Chain 4.0 research and development. With the progress and implementation of Industry 4.0 technologies, it is anticipated that there will be more and more breakthroughs in the models and methods of Supply Chain 4.0. This Special Issue will serve as a helpful reference for Supply Chain 4.0 researchers and practitioners.
    Keywords: Industry 4.0 ; supply chain management and optimization ; Supply Chain 4.0 ; supply chain analytics ; supply chain visibility and connectivity ; supply chain synchronization and coordination ; sustainable supply chain management&nbsp ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Additive manufacturing (AM) processes are gaining more and more attention from many industrial fields, mainly because they are revolutionizing the components’ designs and production lines. The complete industrialization of these processes has to be supported by the full understanding of correlation between AM building conditions and the final materials’ properties. Another critical aspect is that nowadays only a reduced number of materials processable by AM are available on the market. It is, therefore, fundamental to widen the materials’ portfolio, and to study and develop new materials that can take advantage of these unique building processes.
    Keywords: amorphous poly(lactide acid) ; poly(styrene-co-methyl methacrylate) ; polymer blends ; filament extrusion ; 3D printing ; additive manufacturing ; silicon nitride ; high performance ceramics ; photopolymerisation ; lithography-based ceramic manufacturing ; fused-deposition modeling ; mechanical properties ; thermal behavior ; polyetherimide ; fused filament modelling ; design of experiments ; directed energy deposition ; AISI 316L ; microstructure ; LPBF ; as-built ; as-cast ; microhardness ; tensile test ; Ni–Cu alloy ; materials development ; polymers ; metals ; ceramics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    Publication Date: 2024-04-11
    Description: This Special Issue covers symmetry and asymmetry phenomena occurring in real-life problems. We invited authors to submit their theoretical or experimental research presenting engineering and economic problem solution models dealing with the symmetry or asymmetry of different types of information. The issue gained interest in the research community and received many submissions. After rigorous scientific evaluation by editors and reviewers, nine papers were accepted and published. The authors proposed different MADM and MODM solution models as integrated tools to find a balance between the components of sustainable global development, to find a symmetry axis concerning goals, risks, and constraints to cope with the complicated problems. Most approaches suggested decision models under uncertainty, combining the usual decision-making methods with interval-valued fuzzy or rough sets theory, also Z numbers. The application fields of the proposed models involved both problems of technological sciences and social sciences. The papers cover three essential areas: engineering, economy, and management. We hope that a summary of the Special Issue as provided here will encourage a detailed analysis of the papers included in the Printed Edition.
    Keywords: TA1-2040 ; T1-995 ; rough sets ; interval type-2 fuzzy set (IT2FS) ; resources distribution ; the criteria of the weights ; public management ; Step-wise Weight Assessment Ratio Analysis (SWARA) ; multi-criteria decision-making (MCDM) ; symmetry of the method ; quadcopter ; transaction cost ; full fuzzy environment ; dual generalized geometric Bonferroni mean (DGGBM) operator ; data logger ; information theory ; control system ; salvage value ; nonlinear dynamics ; pattern formation ; oscillations ; stability ; Pythagorean fuzzy set ; FAHP ; fuzzy sets ; group decision-making ; generalized Bonferroni mean (GBM) operator ; probabilistic systems analysis ; economic decisions ; 2-tuple linguistic neutrosophic numbers set (2TLNNSs) ; evaluating the quality of distant courses ; subjective weights ; Z-numbers ; green supplier selection ; dual generalized Bonferroni mean (DGBM) operator ; normal cloud ; thrust ; sensor ; neutrosophic numbers ; MCDM ; Bayes’ theorem ; optimal dividend ; logistics ; measurement ; hybrid MCDM ; combining the weights ; data envelopment analysis ; criteria weights ; multiple attribute decision making (MADM) ; IDOCRIW ; excess-of-loss reinsurance ; fuzzy efficiency ; multiple-criteria decision-making (MCDM) ; MCGDM ; transport ; backward cloud transformation ; engineering problems ; rough ARAS ; capital injection ; performance ; Bonferroni mean (BM) operator ; green supply chain management ; population sizes ; hybrid problem solution models ; criteria weight assessment ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: During cell metabolism, oxygen is partially reduced to reactive oxygen species (ROS) that play a physiological role in cellular processes. However, an imbalance between the production of ROS and the ability of defenses to detoxify the organism provokes oxidative stress. Oxidative stress and its subsequent damages to vital cellular components have been associated with numerous severe chronic disorders. In addition, oxidation reactions are responsible for food deterioration during processing and storage. Peptides from animal and vegetal food sources have attracted attention due to the large evidence of their in vitro antioxidant properties. In addition to their potential as safer alternatives to synthetic antioxidants used to prevent oxidative reactions in foods, antioxidant peptides can also act by reducing the risk of numerous oxidative stress-associated diseases. Furthermore, peptides can act synergistically with nonpeptide antioxidants, enhancing their protective effect. This Special Issue of the Foods journal includes outstanding papers illustrating examples of the most recent advances on antioxidant peptides from both vegetal and animal sources. The existing data on their bioactivities demonstrated by in silico, in vitro, and animal models are included as well as the mechanisms of action of identified antioxidant peptides.
    Keywords: food peptides ; reactive oxygen species ; antioxidant enzymes ; whey protein hydrolysate ; hydrolysis condition ; food antioxidant ; ORAC ; cellular ROS ; HepG2 ; peptides ; egg white ; egg yolk ; antioxidant peptides ; sarcopenia ; whey protein ; muscle ; C2C12 ; aged animals ; older adult ; exercise ; bioactive peptides ; animal protein ; multifunctionality ; antioxidant activity ; in silico ; cell models ; fruit residues ; antioxidant ; extraction ; albumin ; albumin peptide ; antioxidant peptide ; bioactive peptide ; mung bean ; mung bean albumin ; peptide sequencing ; Vigna radiata ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The proliferation of powerful but cheap devices, together with the availability of a plethora of wireless technologies, has pushed for the spread of the Wireless Internet of Things (WIoT), which is typically much more heterogeneous, dynamic, and general-purpose if compared with the traditional IoT. The WIoT is characterized by the dynamic interaction of traditional infrastructure-side devices, e.g., sensors and actuators, provided by municipalities in Smart City infrastructures, and other portable and more opportunistic ones, such as mobile smartphones, opportunistically integrated to dynamically extend and enhance the WIoT environment. A key enabler of this vision is the advancement of software and middleware technologies in various mobile-related sectors, ranging from the effective synergic management of wireless communications to mobility/adaptivity support in operating systems and differentiated integration and management of devices with heterogeneous capabilities in middleware, from horizontal support to crowdsourcing in different application domains to dynamic offloading to cloud resources, only to mention a few. The book presents state-of-the-art contributions in the articulated WIoT area by providing novel insights about the development and adoption of middleware solutions to enable the WIoT vision in a wide spectrum of heterogeneous scenarios, ranging from industrial environments to educational devices. The presented solutions provide readers with differentiated point of views, by demonstrating how the WIoT vision can be applied to several aspects of our daily life in a pervasive manner.
    Keywords: TA1-2040 ; T1-995 ; container ; fog computing ; virtual reality ; privacy and security ; software defined infrastructure ; intelligent medical service ; very long instruction word (VLIW) ; semantics ; privacy leakage detection ; context information ; post-copy ; ontology ; body area network ; DSP ; Internet-of-Things ; Mobile Device Management ; interoperability ; Android ; water consumption ; Processing-in-Memory ; performance analysis ; semantic ; mobility ; data management ; CRIU ; training simulator ; Industry 4.0 ; sensor networks ; experimental evaluation ; programming paradigm ; pre-copy ; microservice-oriented platform ; CubeSats ; middleware ; registry ; smart metering ; big data analytics ; nanosatellites ; medium access control ; Internet of Things ; heterogeneity ; web-of-things ; one-to-one computing educational program ; Web-of-Things ; internet of things ; instruction set extension ; microservices architecture ; migration ; behaviour ; wireless access networks ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: As an important tool of systems biology, proteomics has enabled a deep understanding of different plant processes and functions. Complemented with genomic data, computational tools, and improved sample preparation strategies, proteomics has an unprecedented opportunity to characterize plant proteoforms in high spatial and temporal resolution. This special issue of Plant Proteomic Research 4.0 captures the recent advancements in proteomics and addresses the current challenges of plant stress response and resilience in the ever-changing climate. It contains 12 articles, including three reviews and nine original research articles. The three reviews deal with pollen phosphoproteomics, starch biosynthesis-related proteins and posttranslational modifications (PTMs) in rice developing seeds, and PTMs of waxy proteins in rice grain. The nine research articles include three related to temperature, two on water stress, two on salt stress, one on fungal pathogen, and the last one on field-grown potato apoplast proteome. The articles reflect the current frontiers of plant proteomics, focusing on themes of environmental stresses, proteoforms/PTMs, crop species, and new development in data-independent acquisition mass spectrometry. They provide readers insights into current technologies, their utility in understanding plant growth and resilience, as well as directions of proteomics in the frontiers of systems biology and synthetic biology.
    Keywords: peptide markers ; Quercus ilex ; drought tolerance ; targeted post-acquisition proteomics ; plant pathogenesis responses ; quantitative proteomics ; data-independent acquisition ; Phytophthora infestans ; waxy ; amylose ; posttranslational modification ; GBSSI ; rice ; wheat ; salt stress ; physiological characteristics ; ER proteome ; label-free quantitation ; starch biosynthesis ; proteomics ; starch functionality ; cooking and eating quality ; Mesembryanthemum crystallinum ; McHB7 ; transcription factor ; late embryogenesis abundant ; Arabidopsis ; seed germination ; metabolomics ; heat-stable proteome ; dehydrins ; LEA transcripts ; intrinsically disordered proteins ; floral thermogenesis ; Nelumbo nucifera ; DIA-based quantitative proteomics ; time series analysis ; protein-protein interaction network ; WGCNA ; mutant soybean ; flooding ; glycoprotein folding ; fermentation ; cell death ; rice endosperm ; phosphorylation ; high temperature ; sucrose and starch metabolism ; ABPP ; apoplast ; serine hydrolases ; β-glycosidases ; potato ; field-omics ; phosphoproteomics ; pollen tube ; male gametophyte ; root hair ; signal transduction ; kinase motif ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Photoacoustic (or optoacoustic) imaging, including photoacoustic tomography (PAT) and photoacoustic microscopy (PAM), is an emerging imaging modality with great clinical potential. PAI’s deep tissue penetration and fine spatial resolution also hold great promise for visualizing physiology and pathology at the molecular level. PAI combines optical contrast with ultrasonic resolution, and is capable of imaging at depths of up to 7 cm with a real-time scalable spatial resolution of 10 to 500 µm. PAI has demonstrated applications in brain imaging and cancer imaging, such as breast cancer, prostate cancer, ovarian cancer etc. This Special Issue focuses on the novel technological developments and pre-clinical and clinical biomedical applications of PAI. Topics include but are not limited to: brain imaging; cancer imaging; image reconstruction; quantitative imaging; light source and delivery for PAI; photoacoustic detectors; nanoparticles designed for PAI; photoacoustic molecular imaging; photoacoustic spectroscopy.
    Keywords: photoacoustic imaging ; tomography ; thermoacoustic ; radio frequency ; image quality assessment ; image formation theory ; image reconstruction techniques ; sparsity ; signal processing ; deconvolution ; empirical mode decomposition ; signal deconvolution ; photoacoustics ; tissue characterization ; absorption ; Photoacoustic Computed Tomography (PACT) ; ring array ; fast imaging ; low cost ; photoacoustic tomography ; full-field detection ; wave equation ; final time inversion ; uniqueness ; stability ; iterative reconstruction ; 3D photoacoustic tomography ; full-view illumination and ultrasound detection ; photoacoustic coplanar ; quartz bowl ; correlation matrix filter ; time reversal operator ; photo-acoustic tomography ; reflection artifacts ; deep learning ; convolutional neural network ; time reversal ; Landweber algorithm ; U-net ; optoacoustic imaging ; respiratory gating ; motion artifacts ; full-ring illumination ; diffused-beam illumination ; point source illumination ; ultrasound tomography (UST) ; photoacoustic tomography (PAT) ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: Introducing “A Feasible Approach for Natural Products to Treatment of Diseases”–an exploration of the therapeutic potential locked within nature’s abundant offerings. This comprehensive reprint delves into the fascinating realm of natural products, uncovering their inherent properties, mechanisms of action, and potential roles in effective disease management. Through extensive scientific research and reviews, the authors shed light on the immense potential of natural products as a viable approach to enhancing health and combating diseases. This reprint presents a diverse and multidimensional exploration, bridging the gap between traditional wisdom and contemporary scientific understanding and offering new avenues for healthcare professionals, researchers, and enthusiasts to harness the power of nature’s remarkable resources. As a catalyst for unlocking the healing potential of natural products, this reprint inspires further investigation and innovation, and drives us towards a future where their integration into mainstream healthcare becomes indispensable. Discover the possibilities and embark on a health and well-being journey with “A Feasible Approach for Natural Products to Treatment of Diseases”.
    Keywords: cancer immunotherapy ; fructan ; FT-IR ; mass spectrometry ; young green barley ; COVID-19 ; β-glucans ; immunomodulation ; anti-inflammation ; anti-oxidant ; ACE2 regulation ; impedance ; ECIS ; antitumor activity ; anticancer properties ; betulin ; betulinic acid ; Amadori rearrangement compounds ; barley ; anti-obesity ; arginyl-fructose ; adipogenic ; ergosta-5,7,22,24(28)-tetraenol (ERGT) ; cholesta-5,7,22,24-tetraenol (CHT) ; ergosterol biosynthesis ; antimetabolite ; suicide substrate ; Trypanosoma brucei ; coronavirus SARS-CoV-2 ; main protease ; Saussurea costus ; molecular docking ; GC-MS profiling ; Molineria recurvata ; diabetic nephropathy ; urinary biomarkers ; inflammation ; oxidative stress ; walnut ; Juglans regia ; high-fat diet ; insulin resistance ; cognitive function ; JNK/NFκB pathway ; Citri Reticulatae Pericarpium ; flavonoids ; anticancer ; mechanism ; phenotype ; Angelica sinensis polysaccharide ; Astragalus membranaceus polysaccharide ; hexokinase 2 ; glycolysis ; JAK2/STAT3 pathway ; liver regeneration ; Holoptelea integrifolia ; MMP-9 ; wound healing ; friedelin ; oxalactam A ; macrolactam ; anti-Rhizoctonia solani ; Penicillium oxalicum ; molecular dynamics ; non-alcoholic fatty liver disease (NAFLD) ; natural products ; terpenoids ; mechanisms ; treatment ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: In recent years, inorganic oxidic nanomaterials have been extensively investigated for their outstanding properties that allow their use within a large variety of raising fields of interest, ranging from (photo)catalysis to the development of functional nanocomposites. Nanoscopic metal (eventually mixed) oxides are often fabricated following soft-chemistry approaches, characterized by the possibility of favouring specific morphologies, particles dimensions, and surface porosities through different synthetic methods and templating processes. In this context, surface functionalities and reactivity play a major role in the determination of nanomaterials final properties. For this reason, further surface functionalization with specific chemical moieties is often recommended to extend their field of application. This Special Issue, now edited as a book, aimed at extending the comprehension of the mechanisms involved in the synthesis and templating of inorganic oxidic nanomaterials, as well as in their surface functionalization and reactivity. Additionally, this Special Issue aimed at increasing the knowledge on the latest advances of these systems in (photo)catalysis, environmental clean-up processes, energy storage, controlled transport and/or release, biomedicine, sensing, development of smart-materials, stimuli-responsive materials, and nanocomposites. Nanomaterials of interest included: silica, alumina, titania, zirconia, zinc oxide, aluminosilicates, iron oxides, perovskites and titanates, rare earth oxides, and composites. Furthermore, particular attention was dedicated toward studies describing alternative ecofriendly preparation methods.
    Keywords: alumino-silicates ; biomedicine ; ceramics ; clays ; inorganic chemistry ; environmental remediation ; nanomaterials ; porous materials ; mesoporous material ; zero-valent-iron nanoparticles ; methylene blue adsorption ; metal–organic framework ; iridium oxide ; nanostructuration ; IrO2 applications ; IrO2 synthesis ; OER ; C3N4 ; ZnO ; heterojunction ; photocatalyst ; metal oxide nanocomposites ; microstructural analysis ; electrospinning ; polymer substrate ; photodegradation ; LSA 99Mo ; thermodynamic parameters ; solid-phase extraction ; isotherm ; metal oxides NPs ; Ni-Fe-TiO2 nanocomposite ; microstructure ; biocompatibility ; endodontic file ; graphitic carbon nitride ; photocatalysts ; g-C3N4/ZnO ; visible light ; photocatalytic degradation ; inorganic coatings ; functional coatings ; stimuli-responsive polymers ; sol–gel ; antimicrobial ; wear-resistance ; photo-catalytic activity ; UV protection ; calcium oxide-doped carbon nitride nanostructures ; basic fuchsine ; elimination mechanism ; π-π stacking ; magnetic nanoparticles ; magnetite ; solvothermal synthesis ; waste valorization ; green chemistry ; advanced oxidation processes ; experimental protocols ; heterogeneous catalysis ; inorganic thermal activation ; organic pollutants ; perovskites ; physico-chemical characterization ; solution combustion synthesis ; strontium ferrates ; water treatment ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PN Chemistry ; thema EDItEUR::P Mathematics and Science::PN Chemistry::PNK Inorganic chemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The sustainability of water resources worldwide is increasingly imperiled as climate change contributes to the human-induced problems of water supply scarcity and maldistribution. Environmental problems associated with water quality, such as aquifer depletion, land subsidence, the seasonal drying of river flows, waterlogging, the salinization of rivers and groundwater, and human health problems from the excessive use of fertilizers and pesticides will require a radical re-thinking of resource-management policy and new tools to help analysts and regulators craft novel solutions. Over the past several decades, with the advent and rapid progress of computational technology, watershed models have increasingly become important and effective tools for tackling a wide range of water resource and environmental management issues and for supporting regulatory compliance. Statistical and machine-learning methods are being used to support and even supplant more traditional simulation models to improve the estimation of the temporal dynamics and patterns of variability in pollutant concentrations and loads. With the advancements in modeling approaches for water quality, there have also been developments in decision-support tools for water quality management. This reprint describes innovative decision-support approaches from around the world and across sectors that can be applied by stakeholders, government entities, and regulators to reduce environmental pollution and result in cost-effective and sustainable water management strategies.
    Keywords: tree-ring ; flow reconstruction ; pre-development ; estuarine salinity ; salinity intrusion ; water quality forecasting ; decision support ; WARMF ; regression model ; salinity ; irrigated agriculture ; stakeholder involvement ; stream water quality ; CART ; ID3 ; random forest ; bagging ; boosting ; extremely random trees ; Gradient Boosting ; land use factor ; Decision Support System ; water quality forecast ; MLP neural network ; Daubechies 5 wavelet ; long short-term memory network ; hybrid model ; decomposition-and-ensemble ; CE-QUAL-W2 ; EDSS ; SaaS ; irrigation ; agriculture ; policy ; water ; economics ; model ; conservation practices ; decision making ; nutrients ; sediment ; targeting ; water quality ; chemical footprint ; emerging contaminants ; endocrine-disrupting compounds ; footprint calculator ; personal care products ; remote sensing ; geographical information systems ; watershed management ; ambient monitoring ; data collection ; San Joaquin River ; decision support system ; assimilative capacity ; real-time management economics ; drinking water quality ; operational decision-making ; real-time monitoring ; Sacramento-San Joaquin Delta ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology::TQK Pollution control
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Our world is facing many challenges, such as poverty, hunger, resource shortage, environmental degradation, climate change, and increased inequalities and conflicts. To address such challenges, the United Nations proposed the Sustainable Development Goals (SDG), consisting of 17 interlinked global goals, as the strategic blueprint of world sustainable development. Nevertheless, the implementation of the SDG framework has been very challenging and the COVID-19 pandemic has further impeded the SDG implementation progress. Accelerated efforts are needed to enable all stakeholders, ranging from national and local governments, civil society, private sector, academia and youth, to contribute to addressing this dilemma. This volume of the Climate Change and Environmental Sustainability book series aims to offer inspiration and creativity on approaches to sustainable development. Among other things, it covers topics of COVID-19 and sustainability, environmental pollution, food production, clean energy, low-carbon transport promotion, and strategic governance for sustainable initiatives. This book can reveal facts about the challenges we are facing on the one hand and provide a better understanding of drivers, barriers, and motivations to achieve a better and more sustainable future for all on the other. Research presented in this volume can provide different stakeholders, including planners and policy makers, with better solutions for the implementation of SDGs. Prof. Bao-Jie He acknowledges the Project NO. 2021CDJQY-004 supported by the Fundamental Research Funds for the Central Universities. We appreciate the assistance from Mr. Lifeng Xiong, Mr. Wei Wang, Ms. Xueke Chen and Ms. Anxian Chen at School of Architecture and Urban Planning, Chongqing University, China.
    Keywords: climate change ; sustainable development goals ; urban transformation ; decarbonization ; built environment ; governance ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 45
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Research on radiation-tolerant electronics has increased rapidly over the past few years, resulting in many interesting approaches to modeling radiation effects and designing radiation-hardened integrated circuits and embedded systems. This research is strongly driven by the growing need for radiation-hardened electronics for space applications, high-energy physics experiments such as those on the Large Hadron Collider at CERN, and many terrestrial nuclear applications including nuclear energy and nuclear safety. With the progressive scaling of integrated circuit technologies and the growing complexity of electronic systems, their susceptibility to ionizing radiation has raised many exciting challenges, which are expected to drive research in the coming decade. In this book we highlight recent breakthroughs in the study of radiation effects in advanced semiconductor devices, as well as in high-performance analog, mixed signal, RF, and digital integrated circuits. We also focus on advances in embedded radiation hardening in both FPGA and microcontroller systems and apply radiation-hardened embedded systems for cryptography and image processing, targeting space applications.
    Keywords: TA1-2040 ; TK1-9971 ; T1-995 ; single event effects ; n/a ; radiation-hardening-by-design (RHBD) ; frequency divider by two ; single event upset ; Image processing ; CMOS analog integrated circuits ; FPGA ; total ionizing dose (TID) ; Impulse Sensitive Function ; soft error ; hardening by design ; radiation hardening by design ; X-rays ; Single-Event Upsets (SEUs) ; line buffer ; heavy ions ; VHDL ; FPGA-based digital controller ; radiation hardening by design (RHBD) ; radiation hardening ; SRAM-based FPGA ; proton irradiation ; ring oscillator ; sensor readout IC ; fault tolerance ; space application ; physical unclonable function ; voltage controlled oscillator (VCO) ; Ring Oscillators ; analog single-event transient (ASET) ; single event opset (SEU) ; SEB ; single event upsets ; bipolar transistor ; total ionizing dose ; protons ; triple modular redundancy (TMR) ; gain degradation ; space electronics ; saturation effect ; configuration memory ; Co-60 gamma radiation ; total ionization dose (TID) ; frequency synthesizers ; CMOS ; PLL ; TDC ; single-event upsets (SEUs) ; bandgap voltage reference (BGR) ; 4MR ; single-shot ; error rates ; Radiation Hardening by Design ; soft errors ; heavy-ions ; single-event effects (SEE) ; single event transient (SET) ; SEE testing ; proton irradiation effects ; RFIC ; single event upset (SEU) ; FMR ; ionization ; radiation tolerant ; triplex–duplex ; neutron irradiation effects ; digital integrated circuits ; single event gate rupture (SEGR) ; power MOSFETs ; ring-oscillator ; selective hardening ; voltage reference ; nuclear fusion ; TMR ; gamma-rays ; gamma ray ; instrumentation amplifier ; radiation effects ; reference circuits ; radiation-hardened ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 46
    Publication Date: 2024-04-11
    Description: Experiments to characterize the effects of moisture content and temperature on the mechanical properties of concrete were conducted. Based on these experiments, a new overall material model capable of predicting the mechanical behaviour of concrete subject to elevated temperatures up to 100 °C was developed. The material model estimates the time, temperature and moisture dependency of the compressive and tensile strength, creep and shrinkage of concrete.
    Keywords: TA1-2040 ; concrete ; Temperatur ; Beton ; Schwinden ; Temperature ; strength ; Kriechen ; creep ; Festigkeit ; shrinkage ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 47
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Smart sensors are technologies designed to facilitate the monitoring operations. For instance, power consumption can be minimized through on-board processing and smart interrogation algorithms, and state detection enhanced through collaboration between sensor nodes. Applied to structural health monitoring, smart sensors are key enablers of sparse and dense sensor networks capable of monitoring full-scale structures and components. They are also critical in empowering operators with decision making capabilities. The objective of this Special Issue is to generate discussions on the latest advances in research on smart sensing technologies for structural health monitoring applications, with a focus on decision-enabling systems. This Special Issue covers a wide range of related topics such as innovative sensors and sensing technologies for crack, displacement, and sudden event monitoring, sensor optimization, and novel sensor data processing algorithms for damage and defect detection, operational modal analysis, and system identification of a wide variety of structures (bridges, transmission line towers, high-speed trains, masonry light houses, etc.).
    Keywords: TA1-2040 ; T1-995 ; NSGA-II ; wind force ; wavelet packet decomposition ; structural health monitoring ; amplitude spectrum ; environmental noise ; patch antenna ; damage identification ; event-triggered sensing ; Particle Swarm Optimization (PSO) algorithm ; high-speed train ; low-velocity impacts ; concrete structures ; sensors distribution optimization ; acceleration ; digital sampling moiré ; crack ; displacement sensor ; length effect ; FBG sensor array ; SHM ; space window ; Bayesian blind source separation ; feature selection ; stress detection ; wheel minor defect ; strain ; uniaxial stress measurement ; turbine ; impact identification ; helical antenna ; energy analysis of wavelet band ; strain wave ; time window ; structural steel members ; steel frame ; acoustoelastic effect ; demand-based nodes ; online wayside detection ; sensor ; bridge ; sensitivity ; acoustic emission ; bending stiffness ; wireless smart sensors ; distributed dense sensor network ; mapping construction ; data fusion ; fuzzy classification ; shear-wave birefringence ; normal mode ; piezoelectric wafer active sensors ; resonant frequency ; electromagnetic oscillation ; settlement ; sensor optimization ; modal frequencies ; perturbation theory ; feature extraction ; Virtual Distortion Method (VDM) ; reflective optical sensor ; fibre bundle ; smartphones ; crack identification ; active sensing ; test vehicle ; calibration ; stretching method ; model updating ; rotary ultrasonic array ; 2D crack growth ; data processing ; damage detection ; impactor stiffness ; tip clearance ; transmission tower ; phase spectrum ; concrete crack ; structural impact monitoring ; shaking table tests ; optical crack growth sensor ; steel strand ; passive sensing ; sudden event monitoring ; aero engine ; principal component analysis ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 48
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
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  • 49
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 50
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Mobile robotics is a challenging field with great potential. It covers disciplines including electrical engineering, mechanical engineering, computer science, cognitive science, and social science. It is essential to the design of automated robots, in combination with artificial intelligence, vision, and sensor technologies. Mobile robots are widely used for surveillance, guidance, transportation and entertainment tasks, as well as medical applications. This Special Issue intends to concentrate on recent developments concerning mobile robots and the research surrounding them to enhance studies on the fundamental problems observed in the robots. Various multidisciplinary approaches and integrative contributions including navigation, learning and adaptation, networked system, biologically inspired robots and cognitive methods are welcome contributions to this Special Issue, both from a research and an application perspective.
    Keywords: TA1-2040 ; T1-995 ; similarity measure ; swarm-robotics ; drag-based system ; PID algorithm ; human–robot interaction ; behaviour dynamics ; state constraints ; fair optimisation ; micro mobile robot ; robot ; actuators ; high-gain observer ; turning model LIP ; space robot ; manipulation action sequences ; subgoal graphs ; remotely operated vehicle ; constrained motion ; joint limit avoidance ; curvilinear obstacle ; rehabilitation system ; stability criterion ; system design ; quad-tilt rotor ; iterative learning ; spiral curve ; cable detection ; SEA ; douglas–peuker polygonal approximation ; predictable trajectory planning ; ATEX ; obstacle avoidance system ; kinematic singularity ; collision avoidance ; biologically-inspired ; jumping robot ; differential wheeled robot ; design and modeling ; control efficacy ; robotics ; extremum-seeking ; object-oriented ; non-holonomic mobile robot ; magneto-rheological fluids ; rendezvous consensus ; altitude controller ; master-slave ; switching control ; deep reinforcement learning ; mechanism ; expansion logic strategy ; negative buoyancy ; action generation ; radial basis function neural networks ; unmanned aerial vehicles ; extend procedure ; glass façade cleaning robot ; convolutional neural network ; climbing robot ; micro air vehicle ; car-like kinematics ; variable speed ; machine learning ; dynamical model ; transportation ; geodesic ; unmanned surface vessel ; medical devices ; stopper ; extended state observer (ESO) ; high efficiency ; object mapping ; multi-objective optimization ; hybrid robot ; robot learning ; auto-tuning ; cable disturbance modeling ; manipulation planning ; pesticide application ; high-speed target ; sparse pose adjustment (SPA) ; service robot ; lumped parameter method ; Geometric Algebra ; dynamic coupling analysis ; Thau observer ; tri-tilt-rotor ; industrial robotic manipulator ; hardware-in-the-loop simulation ; robotic drilling ; muscle activities ; small size ; chameleon ; continuous hopping ; wall climbing robot ; hover mode ; 3D-SLAM ; curvature constraints ; PSO ; drilling end-effector ; Rodrigues parameters ; gait adaptation ; static environments ; position/force cooperative control ; snake-like robot ; shape-fitting ; powered exoskeleton ; input saturation ; kinematic identification ; methane ; human–machine interactive navigation ; q-learning ; path following ; hopping robot ; mobile manipulation ; high step-up ratio ; actuatorless ; monocular vision ; stability analysis ; compact driving unit ; snake robot ; non-holonomic robot ; curvature constraint ; phase-shifting ; dialytic elimination ; gesture recognition ; snake robots ; series elastic actuator ; flapping ; servo valve ; motion camouflage control ; biomimetic robot ; minimally invasive surgery robot ; centralized architecture ; trajectory planning ; computing time ; adaptive control law ; kinematics ; facial and gender recognition ; single actuator ; victim-detection ; shape memory alloys ; undiscovered sensor values ; discomfort ; Differential Evolution ; numerical evaluation ; quadruped robot ; coverage path planning ; localization ; MPC ; n/a ; fault diagnosis ; neural networks ; disturbance-rejection control ; sample gathering problem ; cart ; bio-inspired robot ; opposite angle-based exact cell decomposition ; optimization ; safety ; goal exchange ; hierarchical planning ; ocean current ; robot motion ; nonlinear differentiator ; mapping ; finite-time currents observer ; Newton iteration ; inverse kinematics ; deposition uniformity ; spatial pyramid pooling ; hierarchical path planning ; end effector ; head-raising ; fault recovery ; LOS ; path tracking ; non-inertial reference frame ; step climbing ; obstacle avoidance ; sliding mode control ; symmetrical adaptive variable impedance ; lane change ; quadcopter UAV ; singularity analysis ; biped mechanism ; fault-tolerant control ; dynamic neural networks ; mobile robots ; data association ; UAV ; enemy avoidance ; reinforcement learning ; grip optimization ; safety recovery mechanism ; exoskeleton ; dynamic environment ; uncertain environments ; hybrid bionic robot ; potential field ; robot navigation ; cleaning robot ; unmanned aerial vehicle ; non-singular fast-terminal sliding-mode control ; contact planning ; Lyapunov-like function ; piezoelectric actuator ; transition mode ; non-prehensile manipulation ; multiple mobile robots ; Tetris-inspired ; real-time action recognition ; integral line-of-sight ; topological map ; alpine ski ; target tracking ; closed-loop detection ; working efficiency ; mathematical modeling ; curve fitting ; force control ; biped robots ; NSGA-II ; mobile robot ; load carriage ; prescription map translation ; artificial fish swarm algorithm ; Q-networks ; self-reconfigurable robot ; G3-continuity ; autonomous vehicle ; loop closure detection ; excellent driver model ; robots ; graph representation ; regional growth ; target assignment ; evolutionary operators ; intelligent mobile robot ; motion sensor ; exploration ; droplets penetrability ; dynamic uncertainty ; simultaneous localization and mapping (SLAM) ; area decomposition ; multi-criteria decision making ; 4WS4WD vehicle ; biped climbing robots ; skiing robot ; ROS ; decision making ; smart materials ; centrifugal force ; missile control system ; formation of robots ; electro-rheological fluids ; pneumatics ; variable spray ; inertial measurement unit (IMU) ; Robot Operating System ; trajectory interpolation ; formation control ; immersion and invariance ; dragonfly ; parallel navigation ; harmonic potential field ; pallet transportation ; mobile robot navigation ; negative-buoyancy ; grip planning ; manipulator ; position control ; external disturbance ; legged robot ; passive skiing turn ; autonomous underwater vehicle (AUV) ; gait cycle ; path planning ; sliding mode observer ; dynamic gait ; self-learning ; polyomino tiling theory ; coalmine ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 52
    Publication Date: 2024-04-11
    Description: The subject of this PhD-thesis is the transferability of Facility Management (FM) by using the example of hospitals in Germany and Iran. The intention is to determine the status and significance of facility management in the project countries, to analyse similarities, semblances and differences in order to develop a system transferability model.
    Keywords: TA1-2040 ; health system ; facility management ; system transferability ; hospital ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 53
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: This book brings together recent research related to urban resilience, in particular, taking into account climate change impacts and hydrological hazards. Due to the complexity of our cities, which are vulnerable and continuously evolving systems, urban resilience should be considered as a transversal and multi-sectorial issue, affecting different urban services, several hazards, and all the steps of the risk management cycle. Within this context, the different pieces of research that form this book deal with the topics of multi-risk and urban resilience assessment, analysis of cascading effects, and the proposal and prioritization of adaptation measures and strategies to cope with climate-related hazards through multi-criteria analysis.
    Keywords: RESCCUE project ; Electrical distribution network ; Flooding ; Risk Assessment ; city resiliency ; GIS model ; drought ; water scarcity ; water availability ; climate change ; hydrological modeling ; resilience ; flooding ; hazard mapping ; risk identification ; sustainability ; urban resilience ; traffic modelling ; resilience assessment ; urban services ; cities ; Ecosystem Services (ES) ; Nature-Based Solutions (NBS) ; Resilience Assessment Framework (RAF) ; stakeholders’ validation ; stormwater management and control ; depth‒damage curves ; urban floods ; properties ; claims ; flood expert surveyor ; fluvial ; pluvial ; tidal ; sewer ; flood ; risk ; modelling ; cascading effects ; urban flood ; water quality ; cost-benefit analysis ; combined sewer overflows ; climate change adaptation ; climate risk ; socio-economic assessment ; flood risk assessment ; 1D/2D hydrodynamic model ; Metro system ; subway ; urban mobility ; pluvial floods ; 1D/2D coupled models ; impact assessment ; adaptation strategies ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 54
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This Special Issue gathers research from different branches of science and engineering disciplines working on experiments and modelling of nanocomposites into one volume. The Guest Editor welcomes papers dedicated to experimental, computational, and theoretical aspects dealing with many important state-of-the-art technologies and methodologies regarding the synthesis, fabrication, characterization, properties, design, and applications, and both finite element analysis and molecular dynamic simulations, of nanocomposite materials and structures. Full papers covering novel topics, extending the frontiers of the science and technology of nanoreinforced composites are encouraged. Reviews covering topics of major interest will be also considered.
    Keywords: TA1-2040 ; T1-995 ; ab initio ; critical yield strength ; carbon nanotube ; impact buckling ; elasticity ; molecular dynamics simulation ; magnetism ; coarse-grained model ; 3D fiber-metal laminates ; mechanical property ; interface ; nanocomposites ; interface force fields ; YN ; graphene/Fe composite ; cohesive element ; stability ; ScN ; delamination propagation ; interfaces ; graphene nanoplatelets ; nanoindentation ; pressure ; molecular dynamics ; piezoelectric property ; temperature effect ; Fe-Al ; hardness ; equivalent fiber ; disorder ; Fe3Al ; elastic modulus ; delamination buckling ; CNT agglomeration ; CNTs/epoxy nanocomposites ; boron nitride honeycomb ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 56
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The ongoing deployment of 5G networks is a key enabler for realizing upcoming services at scale, including the massive deployment of the Internet of Things, providing communications to support autonomous vehicles, and supporting the realization of smart cities. However, as the limitations of existing approaches become apparent, the need for next-generation technologies is growing, in terms of improving spectral efficiency, increasing network data rates and densification, supporting local/wide area wireless coordination, and more. In this Special Issue, we present some technologies to meet these demanding requirements and facilitate coordinating wireless networks to support future Beyond 5G networks.
    Keywords: 5G fiber optic networks ; data-driven service assurance ; next generation networks ; predictive analytics ; live-video delivery ; 5G networks ; virtualized content delivery networks ; network function virtualization ; service function chain deployment ; deep reinforcement learning ; MAC classification ; vehicular networks ; VANETs ; distributed MAC ; centralized MAC ; multi-channel MAC ; single-channel MAC ; spectrum allocation ; private 5G ; mmWave RAN ; modulation and coding schemes ; spectral efficiency ; self-organization ; self-optimization ; self-healing ; SON applications and architecture ; SON design and dimensioning ; machine learning (ML) and artificial intelligence (AI) for SON ; massive Machine-Type Communication (mMTC) ; IoT ; URLLC ; backhauling ; SON for 3G/4G ; 5G and B5G networks ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities
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  • 57
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: This book is a collection of Special Issue articles with a multidisciplinary character, linking biology, medicine, and synthetic organic chemistry. The synthesis and full characterization of about 180 novel organic species, both of natural and synthetic origin, often designed with the support of in-silico studies, are set out in the book. In several articles, molecular hybridization approaches have been used as a successful multi-target strategy for the design and development of novel antitumor agents. Rigorous and careful biochemical studies ranging from in-vitro experiments on a plethora of human-cancer derived cell lines to in-vivo and ex-vivo studies allowed the authors to identify the molecular targets and gain useful information on structure–activity relationships (SAR). For this reason, this collection should interest many readers from different scientific fields.
    Keywords: thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 58
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    Institut Français de Pondichéry
    Publication Date: 2023-12-20
    Description: Ce brahmane déconcerte : à travers une ultime décennie de bohème et d'errance, cet homme de bonne caste, d’une carrure tant physique qu’intellectuelle au-dessus de la moyenne, abolit toute respectabilité et s’applique à s’autodétruire. Telle est l’image que GN laisse de lui-même en fin de vie, réussissant ainsi à brouiller notre vision de son œuvre par l’ombre qu’il projette inévitablement sur elle. Ecrivain d’une rigueur et d’une densité rares, ses thèmes et son style incisif tranchent sur une littérature tamoule de coteaux moyens, plus tournée vers le divertissement. Il lui impose un monde étranger à son lectorat bourgeois et fort peu exploré en tamoul avant lui, celui d’un ‘prolétariat’ urbain grouillant de vie. Sans jamais sombrer dans le misérabilisme ni dans l’idéologie progressiste des intellectuels militants qu’il a fréquentés d’abord, il anticipe brillamment d'une génération sur l’explosion globale des littératures ‘dalit’ mais sans pour autant être intégré à celles-ci. Seul, ignoré ou admiré, il reste largement à découvrir. Son œuvre de fiction, ni réaliste ni populiste, est d’une précision clinique. Le talent de l’écrivain, très conscient mais rebelle à toute théorisation, consiste à peindre en l'éclairant de la lumière la plus crue, sous des angles variés mais toujours impitoyables, la société dans laquelle il situe une action exorcisée de toute métaphysique comme de tout misérabilisme, imperméable à toute sensiblerie, une vision du monde à travers ses soubassements. C’est par en-dessous qu’il en lait découvrir les mécanismes, intéressé par les manipulateurs de tous calibres, petits truqueurs ou ‘brokers’ parvenus, autant et plus que par leurs victimes, fasciné par la complexité des comportements humains et de leur enchaînement.
    Keywords: PN1-6790 ; translation ; short story ; contemporary Tamil literature ; novel ; bic Book Industry Communication::D Literature & literary studies
    Language: French
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  • 59
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: This Special Issue explored different topics concerning recent progress in the synthesis and characterization of suitable innovative macromolecular systems, proposed as carriers of specific antimicrobial molecules, to be employed in the biomedical and pharmaceutical fields. Many infectious diseases are induced by omnipresent micro-organisms, including bacteria, viruses, protozoa, fungi, and algae, and, consequently, are very common, accounting for a significant share of the global disease burden. Unfortunately, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this issue lies in improving the existing antimicrobial delivery systems. In this regard, nanoparticles as well as three-dimensional hydrophilic systems represent valuable tools able to ensure excellent performances. Biocompatible polymeric particles, entrapping these bioactive molecules, are capable of releasing them over a desired period of time, thereby decreasing the frequency of their administration. At the same time, these systems are able to protect antimicrobial drugs from degradation, enhancing their bioavailability. This Special Issue serves to highlight and capture the contemporary progress recorded in this field.
    Keywords: film nanocomposite ; essential oil ; supercritical CO2 ; long-term package ; hybrid nanoparticles ; biocompatible polymer ; antimicrobial amphiphiles ; dynamic light scattering ; scanning electron microscopy ; cell viability from counting of colony-forming unities ; antimicrobial activity of nanoparticles ; Escherichia coli ; Staphylococcus aureus ; Candida albicans ; hydrogel ; polyvinyl alcohol ; aliphatic dicarboxylic acids ; sustained release ; linezolid ; equilibrium swelling ratio ; accumulative release ; thermogravimetric analysis ; gram-negative bacteria ; multidrug resistance ; polymer therapeutics ; colistin ; polymyxin B ; nanoliposomes ; MDR-Bacteria ; chitosan ; nanotechnologies ; plant extracts ; agro-food-wastes ; antimicrobial agents ; polymeric nanocarriers ; mixed polymeric micelles ; drug delivery ; antibiotics ; Pluronic F127 ; antimicrobial agent ; polymeric nanomaterial ; self-assembly ; antimicrobial peptide ; silver nanoparticle ; anti-biofilm ; wound healing ; bromelain ; nisin ; bioactivity ; biomedicine ; carrier ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 60
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Photovoltaic (PV) and concentrated solar power (CSP) systems for the conversion of solar energy into electricity are technologically robust, scalable, and geographically dispersed, and they possess enormous potential as sustainable energy sources. Systematic planning and design considering various factors and constraints are necessary for the successful deployment of PV and CSP systems. This book on solar power system planning and design includes 14 publications from esteemed research groups worldwide. The research and review papers in this Special Issue fall within the following broad categories: resource assessments, site evaluations, system design, performance assessments, and feasibility studies.
    Keywords: thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 61
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 62
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
    Language: English
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  • 63
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    Maven Publishers
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
    Language: English
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  • 64
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Open data and policy implications coming from data-aware planning entail collection and pre- and postprocessing as operations of primary interest. Before these steps, making data available to people and their decision-makers is a crucial point. Referring to the relationship between data and energy, public administrations, governments, and research bodies are promoting the construction of reliable and robust datasets to pursue policies coherent with the Sustainable Development Goals, as well as to allow citizens to make informed choices. Energy engineers and planners must provide the simplest and most robust tools to collect, process, and analyze data in order to offer solid data-based evidence for future projections in building, district, and regional systems planning. This Special Issue aims at providing the state-of-the-art on open-energy data analytics; its availability in the different contexts, i.e., country peculiarities; and its availability at different scales, i.e., building, district, and regional for data-aware planning and policy-making. For all the aforementioned reasons, we encourage researchers to share their original works on the field of open data and energy analytics. Topics of primary interest include but are not limited to the following: 1. Open data and energy sustainability; 2. Open data science and energy planning; 3. Open science and open governance for sustainable development goals; 4. Key performance indicators of data-aware energy modelling, planning, and policy; 5. Energy, water, and sustainability database for building, district, and regional systems; 6. Best practices and case studies.
    Keywords: data envelopment analysis ; Kohonen self-organizing maps ; factor analysis ; multiple regression ; energy efficiency ; social media ; energy-consuming activities ; energy consumption ; machine learning ; ontology ; energy performance certificate ; heating energy demand ; buildings ; data mining ; classification ; regression ; decision tree ; support vector machine ; random forest ; artificial neural network ; open data ; electrification modelling ; Malawi ; OnSSET ; MESSAGEix ; reproducibility ; collaborative work ; open modelling and data ; data-handling ; integrated assessment modelling ; data pre- and post-processing ; space heating ; domestic hot water ; market assessment ; EU28 ; district heating ; data analytics ; big data ; forecasting ; energy ; polygeneration ; clustering ; kNN ; pattern recognition ; heating ; building stock ; heat map ; spatial analysis ; heat density map ; building performance simulation ; parametric modelling ; energy management ; model calibration ; Passive House ; energy planning ; energy potential mapping ; urban energy atlas ; urban energy transition ; energy data ; data-aware planning ; spatial planning ; open data analytics ; smart cities ; open energy governance ; urban database ; energy mapping ; building dataset ; energy modelling ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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  • 65
    Publication Date: 2024-04-11
    Description: The specialty section Earthquake Engineering is one branch of Frontiers in Built Environment and welcomes critical and in-depth submissions on earthquake ground motions and their effects on buildings and infrastructures. Manuscripts should yield new insights and ultimately contribute to a safer and more reliable design of building structures and infrastructures. The scope includes the characterization of earthquake ground motions (e.g. near-fault, far-fault, short-period, long-period), their underlying properties, their intrinsic relationship with structural responses, and the true behaviors of building structures and infrastructures under risky and uncertain ground motions. More specific topics include recorded ground motions, generated ground motions, response spectra, stochastic modeling of ground motion, critical excitation, geotechnical aspects, soil mechanics, soil liquefaction, soil-structure interactions, pile foundations, earthquake input energy, structural control, passive control, active control, base-isolation, steel structures, reinforced concrete structures, wood structures, building retrofit, structural optimization, uncertainty analysis, robustness analysis, and redundancy analysis. This eBook includes four original research papers, in addition to the Specialty Grand Challenge article, on the critical earthquake response of elastic-plastic structures under near-fault or long-duration ground motions which were published in the specialty section Earthquake Engineering. In the early stage of dynamic nonlinear response analysis of structures around 1960s, a simple hysteretic structural model and a simple sinusoidal earthquake ground motion input were dealt with together with random inputs. The steady-state response was tackled by an equivalent linearization method developed by Caughey, Iwan and others. In fact, the resonance plays a key role in the earthquake-resistant design and it has a strong effect even in case of near-fault ground motions. In order to draw the steady-state response curve and investigate the resonant property, two kinds of repetition have to be introduced. One is a cycle, for one forced input frequency, of the initial guess of the steady-state response amplitude, the construction of the equivalent linear model, the analysis of the steady-state response amplitude using the equivalent linear model and the update of the equivalent linear model based on the computed steady-state response amplitude. The other is the sweeping over a range of forced input frequencies. This process is quite tedious. Four original research papers included in this eBook propose a new approach to overcome this difficulty. Kojima and Takewaki demonstrated that the elastic-plastic response as continuation of free-vibrations under impulse input can be derived in a closed form by a sophisticated energy approach without solving directly the equations of motion as differential equations. While, as pointed out above, the approach based on the equivalent linearization method requires the repetition of application of the linearized equations, the method by Kojima and Takewaki does not need any repetition. The double impulse, triple impulse and multiple impulses enable us to describe directly the critical timing of impulses (resonant frequency) which is not easy for the sinusoidal and other inputs without a repetitive procedure. It is important to note that, while most of the previous methods employ the equivalent linearization of the structural model with the input unchanged, the method treated in this eBook transforms the input into a series of impulses with the structural model unchanged. This characteristic guarantees high accuracy and reliability even in the large plastic deformation range. The approach presented in this eBook is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability of built environments in the elastic-plastic range.
    Keywords: TA1-2040 ; fling-step input ; Critical response ; Long-duration ground motion ; double impulse ; forward-directivity input ; triple impulse ; robustness ; Near-fault ground motion ; Ground motion ; Ductility factor ; uncertainty ; resonance ; Structural parameter ; Earthquake Response ; Elastic-plastic response ; Interval analysis ; Multiple impulse ; Earthquake input energy ; redundancy ; Upper bound of input energy ; earthquake engineering ; critical excitation method ; Energy transfer function ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 66
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Catalysis, in the industrial production of chemicals, fuels, and materials, accounts for more than half of gross material production worldwide. Heterogeneous catalysis enables fast and selective chemical transformations, resulting in superior product yield and facilitating catalyst separation and recovery. The synthesis of novel catalysts has emerged as a hot topic for process and product development with numerous research publications and patents. Hence, development of efficient catalysts and their applications is important for sustainable energy production and use, green chemicals production and use, and economic growth. This Special Issue discusses recent developments related to catalysis for the production of sustainable fuels and chemicals and traverses many new frontiers of catalysis including synthesis, characterization, catalytic performances, reaction kinetics and modelling, as well as applications of catalysts for the production of biofuels, synthesis gas, and other green products. This covers the current state-of-the-art catalysis research applied to bioenergy, organic transformation, carbon–carbon and carbon–heteroatoms, reforming, hydrogenation, hydrodesulfurization, hydrodenitrogenation, hydrodemetalization, Fischer–Tropsch synthesis, to name a few. This book highlights new avenues in catalysis including catalyst preparation methods, analytical tools for catalyst characterization, and techno-economic assessment to enhance a chemical or biological transformation process using catalysts for a betterment of industry, academia and society.
    Keywords: HDO ; sulfide catalyst ; NiMo/Al2O3 ; phospholipid ; fatty acid ; choline ; oxidative desulfurization ; oxidative denitrogenation ; hydrotreating ; XPS ; activated carbon ; tert-butyl hydroperoxide ; biofuel ; biodiesel ; hydrocarbon ; waste ; glycerol hydrogenolysis ; in situ hydrogen ; methanol steam reforming ; Ni/Cu/ZnO/Al2O3 catalysts ; chilean natural zeolite ; Brønsted acid sites ; bio-oil upgrade ; catalytic pyrolysis ; nitrogen-doping ; iron nitrides ; light olefins ; CO hydrogenation ; KMnO4 pretreatment ; dry reforming methane (DRM) ; methane ; carbon dioxide ; microwave ; conversion ; catalyst ; selectivity ; thermal integration ; catalyst support ; CoMo sulfided catalyst ; deoxygenation ; cracking and polymerization ; hydrogenation and dehydrogenation ; waste cooking oil ; artificial neural network ; kinetic modeling ; cobalt-praseodymium (III) oxide ; CO-rich hydrogen ; methane dry reforming ; hydrodeoxygenation ; Ni/KIT-6 ; ethyl acetate ; CO2 activation ; methanol synthesis ; atomic layer deposition ; copper nanoparticles ; zinc oxide atomic layer ; hydroprocessing ; FeCu catalysts ; jet fuel ; oleic acid ; catalytic conversion ; catalyst acidity and basicity ; product distribution ; reaction pathways ; molybdenum phosphide ; methyl palmitate ; isomerization ; carboxylic acids upgrading ; ketonization ; deuterated acetic acid ; acetone D-isotopomers distribution ; H/D exchange ; inverse deuterium kinetic isotope effect ; kinetic parameters ; activation energy ; catalytic pyrolysis of biomass ; bio-oil ; sustainable fuels and chemicals ; hydrogenolysis ; desulfurization and denitrogenation ; CO2 utilization ; pyrolysis and cracking ; syngas and hydrogen ; biomass and bio-oil ; catalysis ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 67
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The diversity of wood and non-wood forest products is enormous and reflected in their anatomical, physical and chemical properties as well as their potential applications. Special attention should be given to lesser-known species and even to invasive species, which may be profitable when properly managed, thereby decreasing the overexploitation of threatened species. Besides the market importance of stem wood, other tree components and non-wood forest products, often regarded simply as forest residual materials, are valuable forest resources with various potential applications that can strengthen the circular economy. Assessing the characteristics of these diverse materials, such as their structure and anatomy as well as their physical and chemical properties, is fundamental for evaluating their potential and increasing high-quality end-uses. This knowledge will also contribute to sustainable forest management with enhanced forest diversity and species conservation in addition to the reinforcement of certification and environmental policies.
    Keywords: Calamus zollingeri ; Calamus ornatus ; dynamic vapor sorption ; basic density ; volumetric swelling ; white rot ; mold ; Quercus suber L. ; seasonal variation ; cuticular waxes ; leaves ; new species ; morphology ; wood ; properties ; chemical composition ; spectroscopy ; chemometrics ; unconventional species ; Quercus suber ; cork borer ; cork ; phenolics ; tropical species ; wood anatomy ; wood density ; wood color ; multivariate analysis ; species diversity ; dark-brown zone ; lenticular filling tissue ; quantitative anatomical characteristics ; Quercus variabilis ; reproduction cork ; scanning electron microscopy ; sclereid ; virgin cork ; Cytisus scoparius ; liquefied ; optimization ; eco-valorization ; agro-industrial residues ; Asparagaceae ; lignocellulose ; crystalline cellulose ; syringyl/guaiacyl ; anatomy ; Tilia amurensis Rupr. ; Tilia mandshurica Rupr. & Maxim. ; branch ; wood properties ; papermaking material ; tropical timber ; color parameters ; mid-infrared spectroscopy ; FTIR ratios ; environmental factors ; West African Sahel ; Cupressus funebris Endl. wood ; wood knots ; physical properties ; wood color properties ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNA Agribusiness and primary industries::KNAL Forestry industry
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  • 68
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Energy is an important material basis that can promote the development of human society. Despite the increasing use of renewable energy, the overall energy supply is dominated by fossil fuels. For a long period of time, the main consumption proportion of fossil energy will not change. With the perspective of fossil fuels such as coal, oil, natural gas, shale oil, shale gas, and combustible ice, energy exploration, reservoir reconstruction, and intelligent applications in energy exploitation and energy occurrence geology are currently explored from the perspectives of exploration and exploitation technology. This reprint summarizes the intelligent unmanned mining and its development trends and conducts various research studies, including the stratigraphic correlation of sandy conglomerate in the Yellow River Delta Sag of the Bohai Bay basin, the growth and distribution of coal-measured hydrocarbon source rocks in a mixed platform, the physical and mechanical properties of sandstone, mudstone and granite in the geological environment of deep energy reservoirs, the formation mechanism of energy reservoirs and gas reservoirs, the two-phase flow experiment and numerical simulation in energy mining, the evolution law of cracks in the surrounding rock and the reinforcement principle of gradient support, and the comparison of particle pickup by axial flow and swirling flow in horizontal pneumatic conveying.
    Keywords: intelligent mine ; smart mining ; intelligent working face ; intelligent control ; adaptive ; robotic technology ; seismic rock physics ; sandstone and mudstone ; P-wave and S-wave velocity ; pressure ; temperature ; sandy conglomerate ; Huanghekou Sag ; stratigraphic correlation ; calcite U-Pb dating ; detrital zircon ; pressure-controlled pyrolysis ; oil–water separation ; centrifugal force ; two-phase vapor separation ; cyclone separation ; Tarim Basin ; mixed platform ; delta ; coal-measure distribution ; coal-measure logging response ; axial flow ; swirling flow ; pickup behavior ; coefficient of variation ; tight sandstone gas reservoir ; nuclear magnetic resonance ; fracture ; water blocking ; n/a ; rock mechanical properties ; MMTS ; geothermal development ; geothermal reservoir ; different depth of occurrence ; gas storage ; injection production simulation ; effective permeability ; seepage law ; two-dimensional simulation experiment ; fracture evolution law ; fractured seepage zone ; gradient failure support ; hierarchical control mechanism ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
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  • 69
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Robotics and control are both research and application domains that have been frequently engineered through the use of interdisciplinary approaches like cybernetics. Cognition is a particular concept of this approach, abstracted from the context of living organisms to that of artificial devices, and is concerned with knowledge acquisition and understanding through thought, experience, and the senses. Cognitive robotics and control refer to knowledge processing as much as knowledge generation from problem understanding, leading to special forms of architectures that enable systems to behave in an autonomous way. The main aim of this book is to highlight emerging applications and address recent breakthroughs in the domain of cognitive robotics and control and related areas. Procedures, algorithms, architectures, and implementations for reasoning, problem solving, or decision making are considered in the domain of robotics and control.
    Keywords: initial trajectory ; trajectory optimization ; Bézier surface ; robotics ; open FPGAs ; robot control ; surgical robotics ; human–machine interaction ; autonomous guidance ; low-cost platform ; FPGA ; S-curve ; motion control ; SoC ; telemanipulation ; haptics ; machine learning ; gesture recognition ; upper limb rehabilitation robot ; particle swam optimization (PSO) ; artificial bee colony (ABC) ; Ziegler Nichols ; Maximum sensitivity ; ontology ; robot task planning ; knowledge base ; knowledge representation ; industrial collaborative robots ; shared robotic tasks ; physical human–robot interaction ; human intention recognition ; time series classification ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 70
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: New scientific advances in different areas have allowed the design of more precise strategies for the prevention and treatment of metabolic disorders through nutrition. In this context emerges the term Precision Nutrition, a new approach that takes advantage of scientific knowledge about the interaction of internal and external environmental factors to develop dynamic and precise nutritional recommendations. Therefore, Precision Nutrition includes personalized advice based on genetics and well-documented gene–nutrient–phenotype interactions, as well as other factors such as individual metabolome, transcriptome, and microbiota profile; food behavior; and dietary, physical activity, and life-style habits; and the resulting interactomes. Precision Nutrition should be based at least on three sequential steps: conventional nutritional approaches (considering age, gender, and physiological states); the incorporation of nutritional and health status information (e.g., metabolites, physical and nutritional behavior); and the genetic baggage including multiomics functional integration.
    Keywords: dietary parameters ; carbohydrate intake ; obesity ; single nucleotide polymorphism ; CLOCK gene ; rs3749474 ; sodium intake ; hypertension ; single-nucleotide polymorphism ; personalized nutrition ; dietary vitamin A ; body fat ; UCP ; retinoic acid ; PBMC ; genetic variant ; weight loss ; nutrigenomics ; dietary intervention ; FTO gene ; dietary protein ; dietary carbohydrates ; dietary fat ; macronutrients ; gene-diet interaction ; glucose homeostasis ; glaucoma ; polygenetic-risk scores ; gene-gene interaction ; gene-nutrient interaction ; precision medicine ; childhood ; insulin resistance ; adipokine ; metabolomics ; biomarkers ; ELOVL ; metabolic alterations ; Mexican population ; Single Nucleotide Polymorphisms ; pediatrics ; cardiometabolic risk factors ; precision nutrition ; eating behavior ; nutrigenetics ; microbiota ; metabolic syndrome ; Mediterranean diet ; genetic risk score ; HELENA ; adolescents ; sex ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC4 Cultural studies: food and society
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    Presses universitaires de Rouen et du Havre
    Publication Date: 2023-12-20
    Description: Les Contemplations sont un livre creusé par l'absence, l'exil et le deuil. Le vertige qu'éprouvent poète et lecteurs penchés sur le gouffre n'est pourtant pas celui du vide : ce recueil de la nuit, de la mort et du silence déborde de lueurs, de vie et de voix. Pour mieux saisir l'infini, Hugo le multiplie, grâce aux variations d'un lyrisme qui excède les limites d'une expérience personnelle pourtant fondatrice. La présente étude se propose d'explorer le cosmos réinventé par Hugo, constellation de poèmes qui invite à discerner un sens, au-delà du chaos de la mort et du mal - à contempler le monde pour mieux le créer.
    Keywords: PN1-6790 ; poésie ; bic Book Industry Communication::D Literature & literary studies
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In recent years, the implementation of sustainable concrete systems has been a topic of great interest in the field of construction engineering worldwide, as a result of the large and rapid increase in carbon emissions and environmental problems resulting from traditional concrete production and industry. For example, the uses of supplementary cementitious materials, geopolymer binder, recycled aggregate and industrial/agricultural wastes in concrete are all approaches to building a sustainable concrete system. However, such materials have inherent flaws due to their variety of sources, and exhibit very different properties compared with traditional concrete. Therefore, they require specific modifications in preprocessing, design, and evaluation before use in concrete. This reprint, entitled “Advances in Sustainable Concrete System”, covers a broad range of advanced concrete research in environmentally friendly concretes, cost-effective admixtures, and waste recycling, specifically including the design methods, mechanical properties, durability, microstructure, various models, hydration mechanisms, and practical applications of solid wastes in concrete systems.
    Keywords: high-strength concrete ; energy evolution ; elastic strain energy ; brittleness evaluation index ; concrete ; humidity ; moisture absorption ; moisture desorption ; numerical simulation ; acoustic emission ; AE rate process theory ; corrosion rate ; damage evolution ; axial load ; precast concrete structure ; lattice girder semi-precast slabs ; bending resistance ; FE modelling ; concrete damage ; GSP ; high strength ; hydration ; strength ; penetrability ; rice husk ash ; sustainable concrete ; artificial neural networks ; multiple linear regression ; eco-friendly concrete ; green concrete ; sustainable development ; artificial intelligence ; data science ; machine learning ; bagasse ash ; mechanical properties ; natural coarse aggregate ; recycled coarse aggregate ; two-stage concrete ; materials design ; recycled concrete ; crumb rubber concrete ; crumb rubber ; NaOH treatment ; lime treatment ; water treatment ; detergent treatment ; compressive strength ; materials ; adhesively-bonded joint ; temperature aging ; residual strength ; mechanical behavior ; failure criterion ; steel slag powder ; compound activator ; mortar strength ; orthogonal experiment ; GM (0, N) model ; ultrafine metakaolin ; silica fume ; durability ; fiber-reinforced concrete ; damage mechanism ; uniaxial tension ; cracked concrete ; crack width ; crack depth ; tortuosity ; sustainability ; concrete composites ; sulfate and acid attacks ; WPFT fibers ; coal gangue ; gradation ; cement content ; unconfined compressive strength ; freeze–thaw cycle ; minimum energy dissipation principle ; three-shear energy yield criterion ; damage variable ; constitutive model ; phosphorus slag ; limestone ; sulphate-corrosion resistance ; volume deformation ; blast furnace ferronickel slag ; alkali-activated material ; dosage of activator ; reactive powder concrete ; beam-column joint ; FE modeling ; crack ; cementitious gravel ; fly ash ; age ; optimal dosage ; bamboo ; sawdust ; pretreatment ; bio-based material ; mechanical property ; self-compacting concrete ; supplementary cementitious materials ; hydration mechanisms ; microstructure ; fresh properties ; synthetic polymer ; high temperature ; bentonite-free drilling fluid ; rheology ; filtration ; FRP reinforced concrete slab ; punching shear strength ; SHAP ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials::TNKX Conservation of buildings and building materials
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    Presses Sorbonne Nouvelle
    Publication Date: 2023-12-20
    Description: La modernisation au Brésil se confond avec la constitution du pays. La forme qu'elle y assume se dessine de façon décisive au moment même de l'indépendance en 1822 et se reproduit en temps que modernisation conservatrice tout au long des deux siècles suivants. C'est ainsi qu'elle donne le sentiment d'osciller entre un changement qui ne respecte que peu de limites et la persistance du passé. Cette modernisation à la fois vertigineuse et toujours incomplète a souvent été dramatique, faisant parfois disparaître les marques qui auraient permis de l'évaluer. La conscience culturelle perd alors pied lorsque l'on envisage la portée et le sens des transformations qui l'affectent. La meilleure littérature brésilienne n'a jamais cessé de travailler ces formes contradictoires. C'est sous cet angle que les examinent deux équipes française et brésilienne, dans le cadre d'un accord Usp-Cofecub, en essayant de mettre en lumière les rapports qui s'établissent entre la forme littéraire et le processus social. Elles se sont concentrées sur certains moments où ce rythme particulier se donne à voir avec plus de netteté : le début de la République, l'immigration et l'industrialisation des années 20 puis les transformations post-1945. Trois axes thématiques ordonnent la quinzaine d'études contenues dans le présent volume : regards sur la ville, écriture et idéologie, lyrique et modernité.
    Keywords: PN1-6790 ; ville ; littérature ; Brésil ; modernisation ; bic Book Industry Communication::D Literature & literary studies
    Language: French
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    Presses universitaires de Lyon
    Publication Date: 2023-12-20
    Description: Comment se dire dans son temps quand l'histoire invente l'individu en même temps qu'elle le malmène ? De Waterloo aux Mémoires d'outre-tombe, la publication de mémoires est un phénomène éditorial qui fait parler à l'époque de « fièvre » ou de « manie ». Parmi ces textes, seul le grand œuvre de Chateaubriand aurait eu la grâce, sanctionnée par une postérité toujours active, de transformer en or littéraire le modèle d'écriture pratiqué dans le tout-venant des mémoires. Les moins mal connus de ces derniers sont les mémoires de Fouché, de la duchesse d'Abrantès, de madame de Genlis et les Mémoires d'une Contemporaine. Le succès de ces textes en leur temps n'a d'égal que l'oubli dans lequel ils sont rapidement tombés, dès la seconde moitié du xixe siècle : victimes du divorce, consommé à ce moment-là, entre histoire et littérature. Occulté depuis plus d'un siècle, l'énorme corpus de la mémoire historique publiée entre 1815 et 1848 existe comme un continent englouti. Le mettre au jour, c'est non seulement ressusciter une bonne part du discours de l'époque, mais plus encore observer comment ont été amenés à se rencontrer et donc à se réinventer les modèles de l'expression de soi et de l'histoire. La prose des mémoires est comme un laboratoire où, dans les conditions d'existence nouvelles créées par la Révolution, l'écriture de soi, celle de l'histoire et aussi celle du roman se découvrent partie liée.
    Keywords: PN1-6790 ; prose ; écriture de soi ; histoire ; roman ; autobiographie ; mémoires ; XIXe siècle ; bic Book Industry Communication::D Literature & literary studies
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book is a collection of recent publications from researchers all over the globe in the broad area of high-voltage engineering. The presented research papers cover both experimental and simulation studies, with a focus on topics related to insulation monitoring using state-of-the-art sensors and advanced machine learning algorithms. Special attention was given in the Special Issue to partial discharge monitoring as one of the most important techniques in insulation condition assessment. Moreover, this Special Issue contains several articles which focus on different modeling techniques that help researchers to better evaluate the condition of insulation systems. Different power system assets are addressed in this book, including transformers, outdoor insulators, underground cables, and gas-insulated substations.
    Keywords: TA1-2040 ; T1-995 ; artificial neural network ; simulation ; high-frequency ; artificial flashover tests ; wide bandgap power modules ; tracking ; electrical field strength ; fast-rise square wave voltages ; FDTD simulation ; cable joint ; corona discharge ; feature selection ; post insulator ; earthing systems ; wind speed ; surface discharge ; oil/paper insulation ; oil-paper insulation ; high-magnitude currents and impulse polarity ; UFVM ; Tettex 9520 ; electrical tree ; flashover characteristics ; composite insulator ; partial discharge ; numerical modeling ; saline mechanism ; thermal parameters ; space charge density ; seasonal ; ion flow field ; denoising ; DDX 9121b ; temperature ; transformer asset management ; cavity discharge ; space/interface charge ; insulation health index ; heat transfer model ; leakage current ; machine learning ; partial discharges (PD) ; RF signal ; flashover ; high impulse conditions ; grounding electrodes ; generalized finite difference time domain ; curve fitting ; grounding ; plasma discharge ; outdoor insulators ; flashover dynamic model ; wavelet transform ; degradation ; thermal properties ; bipolar charge transport model ; UHF sensor ; cable ; random walk theory ; tracking test setup ; GIL ; pressure ; modelling ; non-uniform pollution between windward and leeward sides ; calibrator ; secondary arc ; polymeric insulation ; optical-UHF integrated detection ; shoreline ; dry band arcing ; photoelectric fusion pattern ; DDX 8003 ; XLPE ; silicone gel ; partial discharge modeling ; electric field analysis ; NSCT ; electrode’s geometry ; gas ; Comsol Multiphysics ; fast-impulses ; laying modes ; ageing ; cable ampacity ; residual resistance formulation ; finite element analysis ; thermal effect ; hydrophobicity ; soil resistivity ; charge simulation method ; short-circuit discharge ; dry band formation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: In light of the considerable impact of global food supply chains on climate change, more sustainable ways of producing, distributing, and consuming food appear critical for sustainable development. With the aim of contributing to this topic, this Special Issue on sustainable food consumption and food marketing addresses various relevant issues related to food consumption, including innovative and sustainable forms of food production and consumption, animal welfare and meat consumption, price transmission, social media communication, alternative food production, and organic agriculture, among others. As such, this Special Issue sheds light on more sustainable and carbon-friendly food production and consumption systems from various angles. It delivers valuable scientific evidence for the transformation of current carbon-based food supply chains to more eco-friendly, fair, and future-oriented food supply chains.
    Keywords: aquaponics ; Structural Equation Modeling ; consumer behavior ; purchase intention ; willingness to pay ; sustainability ; food market ; veganic ; vegan-organic ; vegan ; stockless ; attitudes ; environmental marketing ; green product ; green consumer ; green purchase decision ; consumer behaviour ; theory of planned behaviour ; sustainable consumption ; Bangladesh ; out-of-home catering ; sustainable nutrition ; variety seeking ; spontaneous choice ; company canteens ; trust ; social media ; small and medium enterprises ; Bresse Gauloise ; choice experiment ; dual-purpose breeds ; faba beans ; Kollbecksmoor ; theory of planned behavior ; Vorwerkhuhn ; White Rock ; green products ; palm oil free ; structural equation modeling ; SEM ; sustainable food consumption ; food waste ; theoretical framework ; food tourism ; community-based tourism ; sustainable development ; community engagement ; rural development ; food heritage ; carbon-friendly food ; emotions ; animal welfare ; cured ham ; discrete choice experiment ; latent construct model ; market instability ; nonlinear empirical dynamics ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Cognitive building is a pioneering topic envisioning the future of our built environment. The concept of "cognitive" provides a paradigm shift that steps from the static concept of the building as a container of human activities towards the modernist vision of "machine à habiter" of Le Corbusier, where the technological content adds the capability of learning from users' behavior and environmental variables to adapt itself to achieve major goals such as user comfort, energy-saving, flexible functionality, high durability, and good maintainability. The concept is based on digital frameworks and IoT networks towards the concept of a smart city.
    Keywords: explainable post occupancy ; humanoid robot ; lighting simulation software ; BIM ; openBIM ; IFC ; IoT ; sensors ; cognitive buildings ; asset management ; digital twin ; BEM ; simulation modelling ; dynamic simulation ; Building Information Modelling (BIM) ; Internet of Things (IoT) ; facility management ; cyber-physical systems ; Building Management System ; Digital Twin ; Post-Occupancy Evaluations ; cognitive ; digital twins ; building lifecycle management ; artificial intelligence ; decision support ; self-learning ; optimization ; building performance simulation ; lighting simulation ; lighting quality ; visual comfort ; office field study ; evidence-based design ; building information modeling ; HVAC ; fan coil ; Internet of Things ; predictive maintenance ; fault detection ; smart building ; sustainable building ; construction projects ; BIM implementation ; stakeholders ; barriers ; construction product ; servitization ; level of evidence ; level curves ; ground slopes ; embankments ; road and rail design ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
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    Publication Date: 2024-04-11
    Description: Energy systems worldwide are undergoing major transformation as a consequence of the transition towards the widespread use of clean and sustainable energy sources. Basically, this involves massive changes in technical and organizational levels together with tremendous technological upgrades in different sectors ranging from energy generation and transmission systems down to distribution systems. These actions generate huge science and engineering challenges and demands for expert knowledge in the field to create solutions for a sustainable energy system that is economically, environmentally, and socially viable while meeting high security requirements. This book covers these promising and dynamic areas of research and development, and presents contributions in sustainable energy systems planning, integration, and management. Moreover, the book elaborates on a variety of topics, ranging from design and planning of small- to large-scale energy systems to the operation and control of energy networks in different sectors, namely electricity, heat, ?and transport.
    Keywords: TA1-2040 ; T1-995 ; n/a ; Romanian coastal environment ; neural networks ; intermittent heating ; wind velocities ; time-space network ; optimal chiller loading (OCL) ; renewable energy ; pure electric buses ; mixed-integer non-linear programming problem (MINLP) ; control system ; FANP ; energy consumption ; load regulation ; energy ; smart box ; novel method ; smart logistics system ; multiple uncertainties ; non-intrusive load monitoring ; wind speed forecasting ; solid waste to energy plant ; uncertain cooling demand ; dual robust optimization ; Black Sea ; field test and numerical simulation ; electric power ; sustainable development ; multi-type bus operating organization ; cuckoo search algorithm ; vehicular emissions ; SWAN ; public transport ; product quality model ; MCDM ; TOPSIS ; heat transfer ; solar energy ; forecasting validity ; information gap decision theory (IGDT) ; photovoltaic systems ; configurations of internal wall ; ensemble empirical mode decomposition ; agricultural pruning ; hot summer and cold winter climate zone ; energy and environmental systems ; feature extraction ; information platform ; pruning biomass ; smart grid ; product usability testing ; meteorological variables ; fuzzy logic ; performance evaluation ; rural residential building ; threshold value of daily operation hours ; datacenter ; wave energy ; thermal comfort ; heat storage and release ; resampling ; risk aversion ; environment ; support vector machine ; internal coverings ; numerical models ; gradient descent ; renewable biomass energy ; demand response ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 80
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 82
    Publication Date: 2023-12-20
    Description: Quelles sont les relations entre les deux genres complexes, variés et changeants que constituent les romans grecs anciens et la poésie, épique, lyrique, dramatique, d’époque archaïque, classique, hellénistique ? Ce recueil de dix-sept articles, issus d’un colloque tenu à Nice en 2013, ouvre à nouveaux frais ce dossier. Au-delà des influences et intertextualités, quatre domaines sont étudiés : lien entre images et figures poétiques et romanesques ; jeux de références, lectures, réécritures ; effets de rythme et jeux de structure ; roman comme poésie et poésie comme roman. Chaque aspect fait l’objet d’approches à la fois théoriques et appliquées, présentant un état des lieux critique et proposant des perspectives renouvelées, voire des interrogations originales. Sont ainsi abordés l’évolution de la prononciation du grec à l’époque impériale, le rapport description/narration et l’ekphrasis , la métaphore et la fiction, la relation des romanciers anciens à la tradition rhétorique voire scolaire, le roman épique ou tragique et la poésie romanesque, ou encore les liens avec la littérature latine. Enfin, ce sont les relations entre théorie littéraire contemporaine et réflexivité ancienne, ainsi qu’entre littérature générale et philologie classique, qui sont ici réinterrogées.
    Keywords: PN1-6790 ; image ; ancient Greek poetry ; fiction ; parody ; description ; prosody ; rhythm ; irony ; ancient Greek novel ; dialogue between arts ; rewriting ; narration ; intertextuality ; pastiche ; sound play ; rhetoric ; sophistic ; bic Book Industry Communication::D Literature & literary studies
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
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  • 84
    Publication Date: 2023-12-20
    Description: Pionnier de la littérature tamoule contemporaine, C. S. Chellappa lui donne avec son chef-d’œuvre, Vâdivâçal, un texte fondateur de la fiction moderne. La langue, colorée, dense, précise, est nouvelle, chargée des saveurs dialectales, vibrante de la vie intime des villageois. Le sujet est plus neuf encore : décrit minutieusement, le jallikkattu, jeu taurin millénaire en train de disparaître, est le cadre d’un conflit dramatique entre un taureau exceptionnel et la vie et l’honneur de deux générations, père et fils, de tombeurs de taureaux. La vision zoome, alterne et halète entre la foule festive et complice et le drame du duel entre l’homme et l’animal, l’empathie de l’auteur allant à tous, pour plus d’émotion et de vérité. « Quand vous aurez lu ces pages, vous garderez le souvenir du taureau, de l’homme et du vâdivâçal. J’ai conscience de vous introduire dans un monde nouveau. » (C.S. Chellappa, préface)
    Keywords: PN1-6790 ; translation ; contemporary Tamil literature ; bullfighting ; bic Book Industry Communication::D Literature & literary studies
    Language: French
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  • 85
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
    Language: English
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The last few decades have seen rapid development in the field of surface engineering and its applications in almost all industrial sectors. Tribological coatings, which are an important aspect of surface engineering, are today applied on machine component surfaces for a diverse range of moving machine components to control (mostly to minimize) friction and wear in order to conserve energy and materials. This reprint book is a compilation of 11 research papers contributed by experts in the field of surface engineering and tribology. These papers have dealt with the synthesis of various types of coatings, characterization and applications under different operating conditions. It is hoped that this reprint book will be of interest, not only to researchers, but also to practicing engineers and technologists in the industry.
    Keywords: Cr-Ti-B-N films ; magnetron sputtering ; microstructure ; friction and wear ; GH4169 alloy ; Ag–Mo co-implantation ; ion-beam-assisted bombardment technology (IBAB) ; wear mechanism ; polymer coating ; graphene ; tribological properties ; elevated temperature ; VCN–Cu films ; mechanical ; friction property ; wear property ; high-entropy alloy (HEA) matrix coating ; plasma spraying ; wear resistance ; microhardness ; bonding strength ; Cu/MoS2 coatings ; Cu-Al/MoS2 coatings ; annealing treatment ; γ2-Cu9Al4 phase ; scratch test ; acoustic emission ; thin films ; silicon carbide ; multilayered AlCrN coating ; Raman spectroscopy ; tribo-corrosion ; sliding wear ; DLC ; MoS2 ; coating ; elastomer ; seals ; TiB2 ; ZrB2 ; coating blade ; anti-wear ; stainless steel coating ; sputtering ; wear ; adhesion ; friction ; structure ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 87
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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  • 88
    Publication Date: 2024-03-27
    Description: This reprint focuses on exploring the relationship between urban form, mobility, and social well-being across neighborhoods, cities, and regions. Understanding more about these relationships is helpful in shaping integrated sustainable urban planning and transport development strategies. All reprint chapters primarily contribute to the existing literature on the interdisciplinary field of the impact of urban planning and transport on social well-being and facilitate novel ways of measuring the abstract concept of well-being, particularly in Asian and European countries. We suggested that further research could explore these themes in greater depth by means of both theoretical frameworks and methodological developments in this integrated field.
    Keywords: social well-being ; social equity ; quality of life ; behavioural change and decision making ; urban mobility ; travel behaviour ; sustainable transport development ; urban and transport modelling ; urban form ; urban planning ; sustainable cities ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 89
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    Unknown
    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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  • 90
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
    Language: English
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  • 91
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: In impulse-based manufacturing technologies, the energy required to form, join or cut components acts on the workpiece in a very short time and suddenly accelerates workpiece areas to very high velocities. The correspondingly high strain rates, together with inertia effects, affect the behavior of many materials, resulting in technological benefits such as improved formability, reduced localizing and springback, extended possibilities to produce high-quality multi material joints and burr-free cutting. This Special Issue of JMMP presents the current research findings, which focus on exploiting the full potential of these processes by providing a deeper understanding of the technology and the material behavior and detailed knowledge about the sophisticated process and equipment design. The range of processes that are considered covers electromagnetic forming, electrohydraulic forming, adiabatic cutting, forming by vaporizing foil actuators and other impulse-based manufacturing technologies. Papers show significant improvements in the aforementioned processes with regard to: Processes analysis; Measurement technique; Technology development; Materials and modelling; Tools and equipment; Industrial implementation.
    Keywords: magnetic pulse welding ; spot welds ; linear coils ; shear lap test ; automotive alloys ; numerical analysis ; LS-DYNA ; impact deformation ; vaporizing foil actuator ; powder compaction ; spallation ; inclined collision welding ; dissimilar material combinations ; impact velocity ; impact angle ; collision velocity ; impulse forming ; bulge forming ; permeability ; conductivity ; adiabatic blanking ; adiabatic shear band ; high velocity ; clearance ; blanked surface ; stress triaxiality ; FE simulation ; electromagnetic forming ; proximity effect ; Lorentz forces ; coil windings ; electro-hydraulic ; pulsed forming ; numerical simulation ; preforming ; collision welding ; impact welding ; welding window ; aluminum and copper ; high-speed imaging ; jet ; cloud of particles ; energy balance ; energy extraction ; melting ; material properties ; interface morphology ; magnetic pulse welding (MPW) ; AA6016 ; aluminum ; 22MnB5 ; press-hardening steel ; interface characterization ; mechanical characterization ; tribological characterization ; high strain rate ; elevated temperature ; additive manufacturing ; 18Ni300 maraging steel ; constitutive modelling ; damage modelling ; machining simulation ; magnetic pulse forming ; electro-hydraulic forming ; high strain rates ; lightweight ; high pulsed power ; formability ; simulation ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 92
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    Presses universitaires de Strasbourg
    Publication Date: 2023-12-20
    Description: Ni école, ni courant clairement identifié, le « nuevo teatro español » rassemble un groupe hétérogène d'auteurs dramatiques espagnols nés entre 1922 et 1942-1944 qu'anime la volonté d'écrire un théâtre en liberté, théâtre de résistance et de subversion esthétiques et politiques, dans le contexte « agonique » de la dernière décennie du franquisme. Les symboles, les valeurs, la langue et les rituels du franquisme sont particulièrement mis à mal dans des cérémonials sacrificiels et sadomasochistes, ludiques et parodiques, où la passion du pouvoir trouve à s'exprimer à travers les scénarios fantasmatiques les plus délirants et transgressifs. Au cours de véritables bacchanales théâtrales et linguistiques, ces auteurs mêlent les figures carnavalesques, christiques et dionysiaques comme conjuration du théâtre mortifère de la scène franquiste où les cérémonials se succèdent : cérémonials de l'auto-glorification de l'autocrate, défilés commémoratifs (18 juillet), cérémonials sacrificiels (répression, torture, exécutions), scénographies urbaines et monumentales grandioses. Défini tantôt comme théâtre underground, tantôt comme théâtre « symboliste », il est surtout un théâtre rituel grotesque néobaroque au ton blasphématoire et à l'esprit d'insolence et de désobéissance. Sont étudiés ici les univers dramaturgiques de quatre de ces auteurs qui participent à la fois de ces trois ordres esthético-politiques : Luis Riaza (1925), Francisco Nieva (1927), Antonio Martínez Ballesteros (1929) et Miguel Romero Esteo (1930).
    Keywords: PN1-6790 ; théâtre ; Espagne ; bic Book Industry Communication::D Literature & literary studies
    Language: French
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This book presents the results of the successful Sensors Special Issue on Intelligent Vehicles that received submissions between March 2019 and May 2020. The Guest Editors of this Special Issue are Dr. David Fernández-Llorca, Dr. Ignacio Parra-Alonso, Dr. Iván García-Daza and Dr. Noelia Parra-Alonso, all from the Computer Engineering Department at the University of Alcalá (Madrid, Spain). A total of 32 manuscripts were finally accepted between 2019 and 2020, presented by top researchers from all over the world. The reader will find a well-representative set of current research and developments related to sensors and sensing for intelligent vehicles. The topics of the published manuscripts can be grouped into seven main categories: (1) assistance systems and automatic vehicle operation, (2) vehicle positioning and localization, (3) fault diagnosis and fail-x systems, (4) perception and scene understanding, (5) smart regenerative braking systems for electric vehicles, (6) driver behavior modeling and (7) intelligent sensing. We, the Guest Editors, hope that the readers will find this book to contain interesting papers for their research, papers that they will enjoy reading as much as we have enjoyed organizing this Special Issue
    Keywords: tracking-by-detection ; multi-vehicle tracking ; Siamese network ; data association ; Markov decision process ; driving behavior ; real-time monitoring ; driver distraction ; mobile application ; portable system ; simulation test ; dynamic driving behavior ; traffic scene augmentation ; corridor model ; IMU ; vision ; classification networks ; Hough transform ; lane markings detection ; semantic segmentation ; transfer learning ; autonomous ; off-road driving ; tire-road forces estimation ; slip angle estimation ; gauge sensors ; fuzzy logic system ; load transfer estimation ; simulation results ; normalization ; lateral force empirical model ; driver monitor ; lane departure ; statistical process control ; fault detection ; sensor fault ; signal restoration ; intelligent vehicle ; autonomous vehicle ; kinematic model ; visual SLAM ; sparse direct method ; photometric calibration ; corner detection and filtering ; loop closure detection ; road friction coefficient ; tire model ; nonlinear observer ; self-aligning torque ; lateral displacement ; Lyapunov method ; automatic parking system (APS) ; end-to-end parking ; reinforcement learning ; parking slot tracking ; deceleration planning ; multi-layer perceptron ; smart regenerative braking ; electric vehicles ; vehicle speed prediction ; driver behavior modeling ; electric vehicle control ; driver characteristics online learning ; objects’ edge detection ; stixel histograms accumulate ; point cloud segmentation ; autonomous vehicles ; scene understanding ; occlusion reasoning ; road detection ; advanced driver assistance system ; trajectory prediction ; risk assessment ; collision warning ; connected vehicles ; vehicular communications ; vulnerable road users ; fail-operational systems ; fall-back strategy ; automated driving ; advanced driving assistance systems ; illumination ; shadow detection ; shadow edge ; image processing ; traffic light detection ; intelligent transportation system ; lane-changing ; merging maneuvers ; game theory ; decision-making ; intelligent vehicles ; model predictive controller ; automatic train operation ; softness factor ; fusion velocity ; online obtaining ; hardware-in-the-loop simulation ; driving assistant ; driving diagnosis ; accident risk maps ; driving safety ; intelligent driving ; virtual test environment ; millimeter wave radar ; lane-change decision ; risk perception ; mixed traffic ; minimum safe deceleration ; automated driving system (ADS) ; sensor fusion ; multi-lane detection ; particle filter ; self-driving car ; unscented Kalman filter ; vehicle model ; Monte Carlo localization ; millimeter-wave radar ; square-root cubature Kalman filter ; Sage-Husa algorithm ; target tracking ; stationary and moving object classification ; localization ; LiDAR ; GNSS ; Global Positioning System (GPS) ; monte carlo ; autonomous driving ; robot motion ; path planning ; piecewise linear approximation ; multiple-target path planning ; autonomous mobile robot ; homotopy based path planning ; LiDAR signal processing ; sensor and information fusion ; advanced driver assistance systems ; autonomous racing ; high-speed camera ; real-time systems ; LiDAR odometry ; fail-aware ; sensors ; sensing ; percepction ; object detection and tracking ; scene segmentation ; vehicle positioning ; fail-x systems ; driver behavior modelling ; automatic operation ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 94
    Publication Date: 2023-12-21
    Description: Reúne textos de especialistas das áreas de Saúde e de Educação com longa, competente e comprometida atuação na luta por mudanças sociais, preocupados com um (con)viver humano mais solidário. A obra mostra ser possível a constituição de serviços de saúde com profissionais sensíveis e preparados para atuar em tempos de novas exigências técnicas e de capacitação profissional. Por instigar a (re)pensar o aperfeiçoamento técnico e ético do trabalho, com idéias e propostas originais e atuais, trata-se, certamente, de contribuição de relevância para aqueles que, direta ou indiretamente, encontram-se engajados na causa do Sistema Único de Saúde.
    Keywords: R5-920 ; Pessoal técnico de saúde-educação ; Ocupação em saúde ; educação profissional ; bic Book Industry Communication::M Medicine
    Language: Portuguese
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  • 95
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-27
    Description: Phytochemicals from natural products are now widely used as food additives (antioxidants, pigments), food supplements, cosmetic ingredients, etc. Currently, the majority of the extraction processes implemented on an industrial scale for the production of bioactive-enriched extracts are based on solvents of petroleum origin. However, contemporary trends in green extraction techniques dictate a minimization of solvent use, low-energy processes and novel eco-friendly materials that are environmentally benign. The search for liquids and/or extraction technologies that could meet such requirements is, therefore, an intriguing concept. This book addresses the concept of recovering natural bioactive substances from plant resources, using state-of-the-art extraction technologies, with prospects in the food, cosmetic and pharmaceutical industries.
    Keywords: cosmeceutical product ; long-lived trees ; simplex-centroid mixture design ; deep eutectic solvents ; bioactivity ; flavonoids ; extraction ; deep eutectic solvents (DES) ; natural deep eutectic solvents (NaDES) ; Moringa oleifera ; polyphenols ; ultrasonication pretreatment ; antioxidants ; hydroxypropyl β-cyclodextrin ; potato peels ; grape seed ; grape skin ; green extraction ; antioxidant activity ; chlorogenic acid ; caffeine ; β-cyclodextrin ; coffee pulp ; sensory analysis ; cold brew ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general
    Language: English
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  • 96
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Physical processes are keys for the status of a lake. In this Special Issue, the emphasis is on dissolved oxygen and on exchange of gases, energy and momentum between atmosphere and further mixing and consumption within the water. The studies presented relate to ice-free as well as ice-covered lakes. Field measurements are combined with theoretical approaches.
    Keywords: hydrodynamic model ; bubble plume ; artificial mixing ; GLM ; Si3D ; dissolved gas ; Henry law ; total gas pressure ; ebullition ; greenhouse gases ; lacustrine waters ; diurnal variation ; hourly model ; water temperature ; dissolved oxygen ; shallow lakes ; and sediment heat flux ; water quality ; chlorophyll-a ; phosphorus ; phosphorus release ; full set of turbulent stresses ; Acoustic Doppler current profilers ; interbeam velocity correlations ; ice-covered lakes ; convectively-mixed layer ; anisotropic turbulence ; shallow lake ; ice-covered period ; ice phenology ; snow-ice cover thickness ; under-ice irradiance ; radiatively driven convection ; climate change ; 3D modelling ; stratification ; bubble plumes ; fractal ; lakes ; mixing ; multi-scale ; turbulence ; energy fluxes ; energy content ; reservoirs ; internal waves ; surface waves ; biogenic turbulence ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology
    Language: English
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  • 97
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: This reprint is devoted to studying RE-doped bulk and nanocrystalline materials from a scientific point of view and to presenting their possible applications in any field. This reprint is intended to serve as a unique multidisciplinary forum covering all aspects of science, technology and applications of rare-earth-doped crystals, starting from the growth techniques with specific attention to the optical and spectroscopic properties of these materials and their applications.
    Keywords: luminescence thermometry ; phosphors ; Er3+ ; Judd–Ofelt ; Slater integrals ; anisotropy ; particle synthesis ; luminescence ; europium-doping ; Lu(OH)2Cl ; Lu2O3 ; europium luminescence ; charge compensation ; niobium ; microwave synthesis ; hafnia ; dispersion ; photoluminescence ; co-precipitation ; anti-counterfeiting ; CaWO4 ; nanoparticles ; in situ TEM ; ion irradiation ; thermal annealing ; ceria ; rare-earth orthochromites ; magnetization reversal ; magnetocaloric effect ; phosphor ; Eu3+ ; niobates ; Judd-Ofelt ; quantum efficiency ; refractive index ; microwave heating ; cerium oxide ; temperature field ; morphology ; SrWO4 ; fingerprint ; K0.3Bi0.7F2.4 ; nanophosphors ; lanthanide ; infrared spectroscopy ; Nd-luminescence ; yttria-stabilized zirconia ; Tb4O7-doped ; annealed in H2/Ar atmosphere ; optical properties ; optical floating-zone method ; saturation spectroscopy ; LYB ; ytterbium ; erbium ; spectral hole ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PN Chemistry
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  • 98
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
    Language: English
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  • 99
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    Unknown
    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: Unconventional reservoirs are usually complex and highly heterogeneous, such as shale, coal, and tight sandstone reservoirs. The strong physical and chemical interactions between fluids and pore surfaces lead to the inapplicability of conventional approaches for characterizing fluid flow in these low-porosity and ultralow-permeability reservoir systems. Therefore, new theories and techniques are urgently needed to characterize petrophysical properties, fluid transport, and their relationships at multiple scales for improving production efficiency from unconventional reservoirs. This book presents fundamental innovations gathered from 21 recent works on novel applications of new techniques and theories in unconventional reservoirs, covering the fields of petrophysical characterization, hydraulic fracturing, fluid transport physics, enhanced oil recovery, and geothermal energy. Clearly, the research covered in this book is helpful to understand and master the latest techniques and theories for unconventional reservoirs, which have important practical significance for the economic and effective development of unconventional oil and gas resources.
    Keywords: TA1-2040 ; T1-995 ; shale gas ; permeability ; prediction by NMR logs ; matrix–fracture interaction ; faults ; remaining oil distributions ; unconventional reservoirs ; coal deformation ; reservoir depletion ; carbonate reservoir ; nanopore ; fracturing fluid ; pseudo-potential model ; shale reservoirs ; matrix-fracture interactions ; multi-scale fracture ; succession pseudo-steady state (SPSS) method ; fluid transport physics ; integrated methods ; chelating agent ; dissolved gas ; non-equilibrium permeability ; effective stress ; fractal ; fracture network ; spontaneous imbibition ; tight oil ; porous media ; 0-1 programming ; the average flow velocity ; geothermal water ; micro-fracture ; pore types ; pore network model ; petrophysical characterization ; nitrogen adsorption ; analysis of influencing factors ; mudstone ; rheology ; velocity profile ; shale permeability ; flow resistance ; global effect ; tight sandstones ; fractal dimension ; contact angle ; temperature-resistance ; fractured well transient productivity ; reservoir classifications ; deep circulation groundwater ; viscosity ; NMR ; fractional diffusion ; lattice Boltzmann method ; multiporosity and multiscale ; fractal geometry ; imbibition front ; productivity contribution degree of multimedium ; wetting angle ; pH of formation water ; enhanced oil recovery ; isotopes ; tight sandstone ; fracture diversion ; shale ; SRV-fractured horizontal well ; low-salinity water flooding ; shale gas reservoir ; tight reservoirs ; fracture continuum method ; tight oil reservoir ; Lucaogou Formation ; hydraulic fracturing ; clean fracturing fluid ; recovery factor ; flow regimes ; local effect ; complex fracture network ; pore structure ; gas adsorption capacity ; polymer ; non-linear flow ; conformable derivative ; production simulation ; analytical model ; enhanced geothermal system ; multi-scale flow ; experimental evaluation ; extended finite element method ; fluid-solid interaction ; groundwater flow ; well-placement optimization ; thickener ; imbibition recovery ; equilibrium permeability ; slip length ; large density ratio ; clay mineral composition ; finite volume method ; volume fracturing ; influential factors ; sulfonate gemini surfactant ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint focuses on basic and applied research on fatigue and fracture processes in engineering of materials and composites. Special attention is given to understanding fracture processes from the point of view of micro and nano damage mechanisms related to material microstructure. Advanced experimental methods such as tomography, digital image correlation, high resolution electron microscopy and fractography are applied in combination with theoretical multiscale models based on finite element methods and fracture mechanics to reveal the fundamental causes of material failure.
    Keywords: cyclic indentation ; Vickers hardness ; inverse analysis ; numerical simulations ; cyclic material properties ; fatigue life ; advanced high-strength steels ; hydrogen embrittlement ; in-situ testing ; scanning electron microscopy ; plasma charging ; coarse-grained Ni-based superalloys ; crystal plasticity ; notch effect ; strain concentration factor ; hull fracture ; inspection manholes ; bulk carrier ; cracks ; corrosion fatigue ; steel quality ; cleavage fracture ; finite element analysis ; local approach ; Weibull stress ; synchrotron tomography ; short fatigue crack growth ; residual stress ; very high cycle fatigue ; silicon carbide ; ceramic matrix composites ; creep properties ; high-temperature strength ; molecular dynamics ; artificial neural network ; forged titanium alloy ; low-cycle fatigue ; cycle wave form ; durability ; crack meso-tunneling ; fractography ; crack growth duration ; ultrasonic fatigue ; frequency effect ; strain rate effect ; environmental effect ; size effect ; high cycle fatigue ; underload cycles ; crack closure ; threshold ; fatigue crack growth ; oxidation ; EA4T steel ; fracture ; gigacycle fatigue ; surface morphology ; kinetic equation ; laminated metallic composites ; toughening mechanisms ; interfaces ; fatigue crack propagation ; large chamber SEM ; ultra-high steel grades ; tensile characteristics ; fracture toughness ; temperature dependence ; modelling fracture ; ductile-to-brittle transition ; local approach to fracture ; ferritic steel ; synchrotron radiation X-ray imaging ; fatigue performance ; fatigue crack ; FGH96 alloy ; microstructure ; micro-indentation ; mechanical and fracture properties identification ; optimisation analysis ; 316L stainless steel ; selective laser melting ; fatigue damage ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TG Mechanical engineering and materials::TGM Materials science
    Language: English
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