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  • bic Book Industry Communication::M Medicine  (1,158)
  • thema EDItEUR::Q Philosophy and Religion::QD Philosophy  (812)
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: In 2015, the United Nations decided to establish the goal of achieving “zero hunger” in the world by 2030 through “outcome targets” such as eliminating hunger and improving access to food, ending all forms of malnutrition, promoting sustainable and resilient agriculture, and maintaining genetic diversity in food production. As a result of this decision, strategies are under way in different countries around the world in the form of political, academic, development, and non-governmental organization projects and programs. Five years later, these strategies have certainly generated results that need to be documented and analyzed so as to answer the following questions: what are the progress and success stories in terms of policies, innovations, technologies, and approaches to reach the zero hunger goal? What are the constraints and mitigation strategies? Are we really in a phase of transition towards the zero hunger goal? What new directions do we need to consider to achieve this goal, particularly in the context of the current COVID-19 pandemic, which affects all sectors of development around the world? This book volume will be published within MDPI’s new open access book series entitled “Transitioning to Sustainability”. It welcomes contributions of empirical research, position pieces, and presentations of important research programs or stakeholder initiatives that cover any of the four “outcome targets” of the zero hunger goal. The contributions may come from academics, students, and policy makers of any region in the world and may be related to specific disciplines or be inter and/or transdisciplinary. They may cover areas including but not limited to sustainable improvement of food production, implementing sustainable food and farming systems, improving access to food, limiting malnutrition, limiting food loss and food waste and, finally, global analyses of the challenges of reaching zero hunger in relation to other sustainable development goals as well as success stories on projects, programmes or government initiatives. Transitioning to Zero Hunger is part of MDPI's new Open Access book series Transitioning to Sustainability. With this series, MDPI pursues environmentally and socially relevant research which contributes to efforts toward a sustainable world. Transitioning to Sustainability aims to add to the conversation about regional and global sustainable development according to the 17 SDGs. Set to be published in 2020/2021, the book series is intended to reach beyond disciplinary, even academic boundaries.
    Keywords: Politics ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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  • 3
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-07
    Description: Originating in the late 19th century and becoming the subject of ongoing methodological debates in the social sciences, methodological individualism is a paradigm that focuses on understanding social phenomena through the actions and choices of individuals rather than through collective explanations. This book highlights its theoretical bases as defined and developed in the writings of its founders and early proponents in the context of the liveliest methodological battles in the social sciences. It addresses fundamental epistemological issues, including the distinction between explanation in the social sciences and natural sciences, the rational bases for understanding social actions, the relation of social wholes to their parts, and the connections between social concepts and the phenomenal world. Bringing together new English translations of foundational texts by Carl Menger, Joseph Schumpeter, Georg Simmel, and Max Weber, this book provides key insights into one of the essential methodological paradigms in the social sciences, corrects misconceptions, and advances a deeper understanding of methodological individualism as a robust and valuable approach to explaining social phenomena. It will therefore appeal to scholars and students of sociology and sociological theory with an interest in questions of social science methodology.
    Keywords: methodological debates ; methodological individualism ; founders ; explanation ; social sciences ; natural sciences ; theoretical bases ; social actions ; social wholes ; social concepts ; phenomenal world ; methodological paradigm ; sociology ; Max Weber ; Joseph Schumpeter ; Carl Menger ; Georg Simmel ; social science methodology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general::GPS Research methods: general ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBA Social theory
    Language: English
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  • 4
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    Springer Nature | Springer Nature Switzerland
    Publication Date: 2024-04-08
    Description: This open access book is a superb collection of some fifteen chapters inspired by Schroeder-Heister's groundbreaking work, written by leading experts in the field, plus an extensive autobiography and comments on the various contributions by Schroeder-Heister himself. For several decades, Peter Schroeder-Heister has been a central figure in proof-theoretic semantics, a field of study situated at the interface of logic, theoretical computer science, natural-language semantics, and the philosophy of language. The chapters of which this book is composed discuss the subject from a rich variety of angles, including the history of logic, the proper interpretation of logical validity, natural deduction rules, the notions of harmony and of synonymy, the structure of proofs, the logical status of equality, intentional phenomena, and the proof theory of second-order arithmetic. All chapters relate directly to questions that have driven Schroeder-Heister's own research agenda and to which he has made seminal contributions. The extensive autobiographical chapter not only provides a fascinating overview of Schroeder-Heister's career and the evolution of his academic interests but also constitutes a contribution to the recent history of logic in its own right, painting an intriguing picture of the philosophical, logical, and mathematical institutional landscape in Germany and elsewhere since the early 1970s. The papers collected in this book are illuminatingly put into a unified perspective by Schroeder-Heister's comments at the end of the book. Both graduate students and established researchers in the field will find this book an excellent resource for future work in proof-theoretic semantics and related areas.
    Keywords: Proof-theoretic Semantics ; Logical Constants ; Proof Theory ; Deductive Logic ; Constructive Logic ; Intuitionistic Logic ; Mathematical Logic ; Peter Schroeder-Heister ; Gerhard Gentzen ; Gottlob Frege ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTL Philosophy: logic ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFA Philosophy of language ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBB Philosophy of mathematics ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBC Mathematical foundations ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general::CBX Language: history and general works ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTL Philosophy: logic ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFA Philosophy of language ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBB Philosophy of mathematics ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBC Mathematical foundations ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general::CBX Language: history and general works
    Language: English
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  • 5
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-04-08
    Description: This open access book sheds light on the term gongsheng/kyōsei, which is used in Chinese and Japanese to not only translate “symbiosis” in biology but also broadly deployed in philosophical, social and political contexts. It is a cross-contextual attempt to study the foundation of gongsheng/kyōsei as a philosophy of co-becoming, with exploration of its significance for thinking about the planetary challenges of our times.
    Keywords: Symbiosis ; Confucianism ; Daoism ; Buddhism ; Human society ; Gong Sheng ; Chinese philosophy ; Mutual Embeddedness ; Environmental philosophy ; Ecological anthropology ; Human-machine relationship ; Co-existence ; Co-becoming ; Social cohesion ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general
    Language: English
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alone and in combination with new therapeutic approaches such as immunotherapies, for the management of cancer. Moreover, the results of clinical trials will likely profoundly affect the direction of the laboratory efforts that are going on in parallel and aiming to improve the personalization of this therapeutic strategy. This Special Issue is our attempt to cover the past and present clinical results that have brought us to this pivotal moment and will form the basis of future clinical developments. Scientists and clinicians caring for cancer patients are well aware of the challenges in dealing with this particular therapeutic approach; one such challenge is obtaining improvements in patient survival without significant toxicity. This edition includes clinical research on chemotherapy and ongoing controversies related to metronomic chemotherapy.
    Keywords: metronomic ; oral cancer ; oral squamous cell carcinoma ; metronomic chemotherapy ; metastatic castration-resistant prostate cancer ; cyclophosphamide ; side effects ; pediatric tumors ; etoposide ; valproic acid ; prostate cancer ; CRPC ; castration ; capecitabine ; paclitaxel ; immunomodulation ; angiogenesis ; microbiome ; breast cancer ; safety ; preclinical studies ; clinical studies ; pharmacokinetic studies ; biomarkers ; chemo-free ; DLBCL ; diffuse-large-b-cell-lymphoma ; elderly ; frail ; comprehensive geriatric assessment ; chemo-endocrine therapy ; FulVEC ; pediatric oncology ; brain tumors ; pharmacology ; medulloblastoma ; ATRT ; immunotherapy ; lymphoma ; vinorelbine ; checkpoint inhibitors ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This collection of articles provides insight into the mental health and nursing care of individuals who are confronting a life-threatening illness. As individuals face a cancer diagnosis, there will be many challenges and changes in their lives. Emotional distress can emerge to greater and lesser degrees. Frequently, these individuals will require additional assistance to cope with the emotional distress they experience. Nurses have an important role in assessing this emotional distress and providing relevant interventions.
    Keywords: Latinx ; family ; meaning ; communication ; coping with advanced cancer ; delirium ; liaison nurse ; misrecognition of delirium ; coordination ; breast cancer ; psychological distress ; quality of life ; women’s health ; qualitative study ; cancer care ; older adults ; mental health ; feeling safe ; home-dwelling ; patients with terminal cancer ; caregivers ; competency in anticipatory grief counseling ; emotional care ; person-centered care ; qualitative research ; anxiety ; depression ; family involvement ; hepatocellular carcinoma ; palliative care ; cancer ; decision-making ; nurse ; caregiving self-efficacy ; family caregiver ; oral cancer ; oncology ; nursing ; clinical nurse specialists ; cancer patients ; expanding nurses’ authority ; professionalization ; policy ; education ; bic Book Industry Communication::M Medicine
    Language: English
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Obstructive sleep apnea is a highly prevalent disorder with strong associations with cardiovascular, cerebrovascular, metabolic, and cognitive consequences, including drowsy driving. Positive Airway Pressure treatment is the first-line therapy for adults with obstructive sleep apnea who are symptomatic. However, many individuals with comorbidities do not report symptoms that are associated with the disorder, and adherence to treatment is poor, especially in individuals with cardiovascular diseases. This reprint contains reviews and original articles that aim to update the current perspectives on the treatment modalities of obstructive sleep apnea to highlight multidisciplinary approaches, personalized treatment strategies, and the identification of the predictors of a patient’s response to treatment, both in the general population and in clinical cohorts.
    Keywords: obstructive sleep apnea (OSA) ; continuous positive airway pressure (CPAP) ; mandibular advancement devices ; upper airway surgery ; drowsy driving ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
    Language: English
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  • 9
    Publication Date: 2024-01-08
    Description: Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimizing biological treatment in patients with inflammatory bowel disease (IBD) and other immune-mediated inflammatory diseases (IMID). Reactive TDM has rationalized the management of primary non-response and secondary loss of response to biologics, while cumulative evidence suggests that proactive TDM is efficacious for optimizing anti-tumour necrosis factor (anti-TNF) therapy in patients with IBD. Proactive TDM can be very useful for optimizing biological therapy in specific IBD populations, such as pregnant women as well as patients with perianal fistulizing Crohn’s disease and acute severe ulcerative colitis who are characterized by high drug clearance. Preliminary data suggest that proactive TDM may also have a role in de-escalating anti-TNF therapy in patients in clinical remission including stopping the immunomodulator when combined with anti-TNF therapy. However, several knowledge gaps and limitations hinder the wide implementation of TDM in clinical practice, including the optimal drug concentration to target the lag time between sampling and results and the lack of harmonization of TDM assays. Recent advances regarding the role of TDM include the use of rapid point-of-care assays and the incorporation of model-informed precision dosing. The aim of this Special Issue is to highlight the clinical utility of TDM and discuss the barriers and recent advances of TDM of biologics in IBD and other IMID.
    Keywords: ulcerative colitis ; Crohn&rsquo ; s disease ; inflammatory bowel disease ; infliximab ; adalimumab ; certolizumab pegol ; golimumab ; vedolizumab ; ustekinumab ; therapeutic drug monitoring ; immunogenicity ; rheumatoid arthritis ; ankylosing spondylitis ; psoriasis ; clearance ; model informed precision dosing ; bic Book Industry Communication::M Medicine
    Language: English
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  • 10
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    Oxford University Press
    Publication Date: 2024-04-04
    Description: What is Structural Injustice? is the first edited collection to bring together the voices of leading structural injustice scholars from politics, philosophy and law to explore the concept of structural injustice which has now become a central feature of all three disciplines and is considered by many to be a ‘field of study.’ The volume features specially selected original and essential works on structural injustice. The volume provides a range of disciplinary, ontological and epistemological perspectives on what structural injustice is and includes feminist and post-colonial theories to interrogate how structural injustice exacerbates and reproduces existing inequalities and relations of power. This book aims to become a touchstone text for those interested in the different ways we can understand structural injustice, how it manifests, how it relates to other forms of injustice, who is responsible for its redress and the different ways we might go about it. This book will appeal to a wide audience of students, both undergraduate and postgraduate, as well as the general academic population, experts on structural injustice, interested practitioners in politics and members of the public.
    Keywords: " Structural injustice, politics, philosophy, law, ontology, epistemology, feminism, power, historical injustice. " ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Inflammatory bowel disease (IBD) encompasses chronic idiopathic relapsing and remitting gastrointestinal autoimmune diseases characterized by chronic inflammatory disorders of complex etiology, posing clinical challenges due to their often therapy-refractory nature. The primary disorders within the IBD classification are ulcerative colitis (UC) and Crohn’s disease (CD), sharing similarities but exhibiting distinct differences, sometimes making their discrimination challenging.A prominent feature of IBD is the inflammation of the intestinal mucosa, characterized by the robust and persistent infiltration of immune cells and compromised intestinal barrier integrity, leading to a phenomenon known as “leaky gut.” Inflammation can manifest acutely or chronically, known as relapsing, and can increase in severity over time, thereby causing life-long morbidities and reduced quality of life for affected individuals, underscoring the need for a deeper comprehension of the molecular contributors to disease pathogenesis and progression.
    Keywords: inflammatory bowel diseases ; cell autofluorescence ; immune cells ; NADH ; FAD ; flow cytometry ; multiphoton microscopy ; colitis ; colitis-associated cancer ; inflammatory bowel disease ; colorectal cancer ; colon adenocarcinoma ; ulcerative colitis ; Crohn’s disease ; cDNA microarray ; transciptomics analysis ; microarray ; inflammatory bowel diseases (IBDs) ; vasculature ; angiogenesis ; gut vascular barrier ; vessel permeability ; epithelial barrier ; homeostasis ; acetylcholine ; muscarinic receptor ; non-neuronal acetylcholine ; mucosal wound healing ; ferroptosis ; leaky gut ; inflammatory bowel disease (IBD) ; triple-culture ; Caco-2 ; HT29-MTX-E12 ; THP-1 ; monocyte-derived macrophage ; inflammation ; TEER ; FITC-dextran 4 kDa (FD4) ; pro-inflammatory cytokines ; HIF-1α ; PHD2 ; AKT ; intestinal epithelial cells ; probiotics ; LPS ; antigen-specific T-cells ; celiac disease ; gliadin ; IBD ; food antigens ; intestinal Behcet’s disease ; immune mechanism ; biological agents ; claudin ; tight junctions ; barrier function ; gut ; ZO-1 ; actin ; cell migration ; cell division ; colon cancer ; PMNs ; LDs ; FOXO3 ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 12
    Publication Date: 2024-04-16
    Description: The internet is changing the way that knowledge is made and shared. Knowledge-making in face-to-face settings is being replaced by information gathering from remote sources, whose origins may be concealed but which can create an illusion of intimacy. Though remote communication is beneficial in many ways – modern societies would fail without it -- and though the tight boundaries of the face-to-face can be used for evil purposes such as criminal conspiracy, if the overall trend to remote communication continues unchecked, it could be disastrous for the future of democracy and the very idea of truth itself. Too much reliance on remote communication threatens the core institutions of democratic societies. We explain the change in technical detail, from a systematic analysis of the workings of the face-to-face to a high level setting-out of its dangerous political implications. The analysis includes field studies, reflexive examination, drawing on the wide experience of the authors, of the stickiness of the face-to-face in our own work and other institutions, and network analysis which explains the illusion of intimacy that can be generated inadvertently or maliciously. We look at the apparent effectiveness of techniques such as blockchain and the limits of their domain. New information is provided about the malicious use of disinformation by foreign powers. We dramatise the dangers to Western pluralist democracy through a personal accounting of the 2020 American election. By drawing out the special features of face-to-face interaction and its constitutive role in creating societies, with science as the icon, the book sets out an agenda for civic education that can protect democratic institutions from the erosion of pluralism and the facile abandonment of trustworthy expertise. The authors conclude by returning to the themes set out at the start of the book, namely the crucial role played by trust in modern societies and the importance of face-to-face interactions in reproducing that trust, and the democratic institutions in which it should be invested.
    Keywords: Democracy; Remote communication; Social media; Disinformation; Trust; Face-to-face communication ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKV Crime and criminology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies::JBCT4 Media studies: journalism ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::J Society and Social Sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
    Language: English
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  • 13
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-05
    Description: Le temps est le concept de transition par excellence qui a certes son origine dans la Nature, mais qui permet aussi l'idée d'un développement de l'esprit - et c'est l'esprit (Geist) qui apparaît ensuite dans un autre cadre – le cadre de l'histoire. La difficulté d'une telle logique du temps, c'est de concevoir un seul concept du temps qui peut contenir deux sphéres opposées, celle de la nécessité dans la nature et celle de la liberté dans l'histoire.
    Keywords: Hegel ; Zeit ; Philosophie ; Deutscher Idealismus ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Recent years have seen growing interest in equine lung and heart health, and advances in technology and a focus on equine welfare have driven this research. This Special Issue explores novel diagnostic and therapeutic approaches, including imaging techniques and lung function testing, immunological features, and immunomodulatory treatments for equine asthma and common racehorse respiratory issues. Moreover, it reports on novel echocardiography data of donkeys. This collection offers valuable insights into equine cardio-respiratory medicine.
    Keywords: equine asthma ; exercise-induced pulmonary hemorrhage ; racehorse respiratory medicine ; donkey cardiology ; bic Book Industry Communication::M Medicine
    Language: English
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue focuses on treating the associated comorbidities and complications of cerebral palsy. Increased prescription of technology means that we are treating some comorbidities of cerebral palsy earlier or even pre-emptively. Increased life expectancy, compared with 20 years ago, means that we are also seeing even later complications of cerebral palsy. However, increased access to intensive medical care at home, non-invasive ventilation, and total parenteral nutrition now exist. There is also greater engagement with the perspectives and expectations of parents/carers and children. As society begins to discuss mental health more openly, we are also starting to recognise the significant two-way associations between disability and mental health. Ethical consultation may be warranted when harm with treatment exceeds the benefit. As we prepare children with cerebral palsy for adulthood, there is more thought and discussion around issues such as pain, mental health, quality of life, independence, and participation. Researchers in the field of cerebral palsy have contributed original articles and reviews which help build our evidence base to guide shared decision making.
    Keywords: mental health ; anxiety ; depression ; cerebral palsy ; adolescence ; young adults ; young people ; adolescents ; unmet need ; health services ; physical therapy ; occupational therapy ; fracture ; bone fragility ; mortality ; epidemiology ; age-adjusted mortality rates ; death certificate ; medical education ; severe neurological impairment ; scoliosis ; shared decision-making ; respiratory ; hospitalisations ; antibiotics ; Indigenous ; inequities ; cell therapies ; stem cells ; comorbidities ; outcome measures ; clinical studies ; inflammation ; biomarker ; comorbidity ; scoping review ; co-design ; intervention ; participation ; involvement matrix ; public and patient involvement ; early intervention ; infant vocalisations ; infants ; single-subject research design ; CP ; infant ; stress ; parents ; fathers ; parent–infant interaction ; representations ; epilepsy ; children ; neuroimaging ; seizure outcome ; Sialorrhea ; submandibular duct relocation ; postoperative management ; ultrasound ; piecewise model ; muscle volume ; cross-sectional area ; GMFCS ; upper limb ; sensory function ; bimanual intensive functional therapy ; hand function ; associated impairment ; register ; low- and middle-income country ; hip displacement ; hip surveillance ; adductor-psoas release ; hip reconstruction ; guided growth ; salvage surgery ; disability ; emotion regulation ; atropine ; sialorrhea ; pediatric ; drooling ; sublingual ; developmental disorders ; neurodevelopmental disorders ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 16
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-05
    Description: Subject of this book is an epistemological consideration concerning the nature of knowledge. But other than the most essays on the subject of knowledge, here I am going to deal with a largely overlooked account to try to find an answer to the question of knowledge. This is the mental state account of knowledge. Or to put it into the main question: is knowledge a mental state? Now, the question is: Why is the epistemic thinking of Cook Wilson, Prichard and Austin afflicted with such ignorance in contemporary epistemic discussions? The answer is: an unreflected Platonian heritage during 2000 years of epistemic thinking -- a notion which is similar to a point Hetherington has called ``epistemic absolutism''. So my main conclusion here is: the JTB thesis (knowledge is some aspect of justified true belief) is insufficient in order to give an account of the nature of knowledge. A consequence from this is: all the epistemic theories which are dealing with the JTB thesis are based on deficient assumptions. Hence their results -- notably the well-known externalism/internalism debate - are insufficient, too. So, there is a need for a new theory of knowledge based on the MS thesis.
    Keywords: Wissen ; Erkenntnistheorie ; John Cook Wilson ; Harold Arthur Prichard ; John Langshaw Austin ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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  • 17
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-04-11
    Description: In this open access book, Timothy Aylsworth and Clinton Castro draw on the deep well of Kantian ethics to argue that we have moral duties, both to ourselves and to others, to protect our autonomy from the threat posed by the problematic use of technology. The problematic use of technologies like smartphones threatens our autonomy in a variety of ways, and critics have only begun to appreciate the vast scope of this problem. In the last decade, we have seen a flurry of books making “self-help” arguments about how we could live happier, more fulfilling lives if we were less addicted to our phones. But none of these authors see this issue as one involving a moral duty to protect our autonomy.
    Keywords: Kantian ethics ; technology ; social media addiction ; artificial intelligence ; distraction ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence
    Language: English
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  • 18
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint entails descriptions of novel issues and challenges for primary mental healthcare regarding both general and vulnerable populations on a global scale. It is intended for health professionals and all who are interested in mental health care at the primary level.
    Keywords: depression ; sense of coherence ; burnout ; COVID-19 ; nurses ; medication adherence ; mental health nurses ; tacit knowledge ; schizophrenia ; sensory processing sensitivity ; environmental sensitivity ; university students ; nursing ; scale ; somatization ; number of diseases ; coping strategies ; sex ; aggression ; alexithymia ; comprehensibility ; quality of life ; family caregivers ; students ; medical ; psychological problem ; undergraduate ; Saudi Arabia ; n/a ; prospect theory ; applied psychology ; health ; decision making ; behavior ; prevention ; multiple sclerosis ; Beck depression inventory ; anxiety ; fatigue ; mediation ; lawyers ; suicidal ideation ; occupational stress ; loneliness ; perceived stress ; mental health ; work overcommitment ; mental health care ; adolescence ; internalizing/externalizing problems ; social skills ; neurodevelopmental disorders ; filmmaking intervention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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  • 19
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    Taylor & Francis | Routledge
    Publication Date: 2024-03-23
    Description: Increasingly social activists, journalists and policy makers have expressed concern over the proliferation of conspiracy theories in the public space. There is a growing fear of their impact on social cohesion and democracy, their power to erode trust in state institutions and science. These concerns often come with an expectation that it is the responsibility of academics to engage with conspiracy beliefs by countering them. But should they? In this book, contributors show that like everything that relates to conspiracy theories, even the answer to this question is not straightforward and can vary across disciplines and schools, can be influenced by disciplinary ethical codes of conduct, research methodologies, and specific approaches to conspiracy theories. Foregrounding a variety of approaches, from across disciplines (psychology, anthropology, sociology and media studies), academic seniority (from young scholars to full professors), and countries (USA, Ireland, UK, The Netherlands, Sweden, and Greece), the chapters in this book are in deep conversation with each other, offering multiple alternative takes on the issue of what should academics do with conspiracy theories. Together, the book embodies several bold and compelling provocations to dealing differently with conspiracy theories. This timely volume introduces perspectives of scholars representing media studies, anthropology, psychology and sociology and discusses case studies concerning politics, health, environment and security. It will be a key resource for researchers, scholars and practitioners engaged in these fields and will also appeal to anyone interested in conspiracy theories and other related phenomena such as disinformation or fake news. This book was originally published as a special issue of the Journal for Cultural Research.
    Keywords: Conspiracy Theories;Greek environmentalism;HPV immunisation;debunking conspiracy theories;media and communication ; thema EDItEUR::A The Arts::AB The arts: general topics ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMA Psychological theory, systems, schools and viewpoints ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTC Communication studies ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GL Library and information sciences / Museology ; thema EDItEUR::L Law::LA Jurisprudence and general issues ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNT Social law and Medical law ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies ; thema EDItEUR::J Society and Social Sciences::JN Education::JNA Philosophy and theory of education ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMH Social, group or collective psychology ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNQ IT and Communications law / Postal laws and regulations ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics::UBW Internet: general works ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPW Political activism / Political engagement::JPWC Political campaigning and advertising
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint includes studies on diagnosing, evaluating and managing the pathologies diagnosed during pregnancy. The information provided in these pages is helpful for specialists in obstetrics and gynaecology but also for other medical specialities involved in treating pregnant women with associated pathologies. Studying the articles in the reprint could contribute to improving case management.
    Keywords: pregnancy ; fetus prenatal care ; high-risk ; pathology ; bic Book Industry Communication::M Medicine
    Language: English
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    Peter Lang International Academic Publishers
    Publication Date: 2024-04-11
    Description: The book aims to formalise tableau methods for the logics of propositions and names. The methods described are based on Set Theory. The tableau rule was reduced to an ordered n-tuple of sets of expressions where the first element is a set of premises, and the following elements are its supersets.
    Keywords: Formalization ; Gałecki ; Hartman ; Iwona ; Jarmuzek ; Leśniewicz ; Logic ; logic of names ; logical ; Łukasz ; Methods ; philosophical logic ; proof theory ; Propositional ; propositional logic ; Sentences ; Tableau ; tableu methods ; Term ; Tomasz ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The aim of this Special Issue is to specify relevant principles of mathematics and mechanics in order to explore and understand biological problems. We summarize the most important parameters that influence human performance and that are related to the health sciences for all age groups, throughout their lives. We present papers that aim to introduce the latest research in the fields of health, quality-of-life improvement, and sport rehabilitation and that summarize their recommendations for best practice. The aim for this Special Issue is, therefore, to effectively combine and coordinate research and results in order to understand and improve human movement in medicine, sports, and at work.
    Keywords: tendinopathy ; Achilles tendon ; hyaluronic acid ; viscoelastic properties ; isometric contraction ; matrix metalloproteinase 3 ; interleukin-1beta ; fascia ; chronic low back pain ; myofascial release ; quality of life ; older adults ; oldest-old ; measurement invariance ; SHARE European Survey ; therapeutic exercises ; chronic neck pain ; scapular dyskinesia ; DOMS ; vibration ; post-exercise muscle damage ; physical exercise ; recovery ; women’s rugby ; anthropometry ; body composition ; adiposity ; somatotype ; lower-body strength ; accelerometry ; falls ; squat jump ; syndesmosis ; anterior inferior tibiofibular ligament ; high ankle sprain ; rotational instability ; posterior malleolus ; stabilization ; anatomic repair ; syndesmotic screw ; suture-button ; internal bracing ; treatment algorithm ; cardiac rehabilitation ; peripheral artery disease ; COVID-19 ; intermittent claudication ; review ; pressotherapy ; compression ; regeneration ; return-to-play ; rotator cuff repair ; shoulder injuries ; shoulder surgery ; shoulder assessment ; chronic obstructive pulmonary disease ; COPD ; acupuncture ; acupuncture therapy ; acupuncture treatment ; health-related quality of life ; anterior knee laxity ; stiffness ; general joint laxity ; genu recurvatum ; low back pain ; physical activity ; trunk alignment ; rasterstereographic system ; young males ; tissue flossing ; floss band ; vascular occlusion ; muscle strength ; muscle endurance ; warm-up ; TECAR therapy ; high-intensity laser therapy ; manual therapy ; muscle disorders ; hemophilia ; knee ; virtual reality exposure therapy ; joint pain ; physiotherapy ; daily physical function ; middle-aged and older adults ; CHARLS ; aging ; appendicular muscle mass ; inflammaging ; biomarkers ; adiponectin ; sarcopenia ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The 3D analysis of human movement aims to objectively and quantitatively assess motor functions and alterations. It is a valuable method for sport scientists, coaches, and clinicians to evaluate sport performance, common movements, and alterations. The feasibility of 3D analysis is increasing because it can be adopted both in a laboratory setting or directly in the field, in static or dynamic conditions, and for physiological or pathological movements. This evaluation technique can be adopted for many people, including children, adolescents, adults, and older people, whether they are sedentary or athletes and whether they are healthy or motor-impaired people.
    Keywords: virtual reality ; augmented reality ; lifelogging ; mirror world ; health ; posture training ; feedback ; COVID-19 ; neck-shoulder-region ; shoulder protraction ; upper crossed syndrome ; posture weakness ; physical inactivity ; sedentary behavior ; soccer ; climbing ; exhaustion ; fatigue ; training ; machine learning ; sports ; gender ; data mining ; artificial intelligence ; posture ; reproducibility ; mobile app ; movement ; kinesiology ; sport performance ; inertial sensor ; inertial sensor device ; inertial measurement unit ; training load ; external load ; physical demand ; handstand ; postural control ; postural balance ; sEMG ; stabilometric assessment ; exercise ; Nordic walking ; walking ; 3D kinematics ; biomechanics ; gait analysis ; kyphosis ; spinal mouse ; photogrammetry ; postural evaluation ; bicycle ; cyclists ; saddle pressure ; perineal pressure ; urogenital system ; injury prevention ; cervical ROM ; elastic taping ; neck pain ; musculoskeletal health ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In the orthopedic surgical field, knee surgeries, including articular cartilage repair procedures, meniscus surgery, ligament reconstruction surgery, osteotomy surgery, and partial/total knee arthroplasty surgery, have made great advances over the last few decades. This Special Issue highlights and focuses on the surgical concepts and techniques, decision-making processes, perioperative management protocols, and clinical outcomes of the recent various advanced knee surgery procedures.
    Keywords: high tibial osteotomy ; TomoFix ; plate position ; anatomical conformity ; dual-energy CT ; Hounsfield unit ; bone mineral density ; volumetric phantomless BMD ; opportunistic CT ; orthopedic surgeon ; planning ; survey ; total knee arthroplasty ; unicompartmental knee arthroplasty ; anterior cruciate ligament ; reconstruction ; bone tunnel widening ; adjustable-loop device ; interference screw ; hamstring tendon ; autograft ; tibial component alignment ; radiographic references ; extramedullary system ; tranexamic acid ; clamping time ; transfusion ; estimated blood loss ; continuous cold flow therapy ; cryotherapy ; pain ; opioids consumption ; patient satisfaction ; bone marrow lesion ; knee ; meniscus ; root tear ; root repair ; femorotibial joint ; chondromalacia ; aging ; body mass index ; magnetic resonance imaging ; automated detection ; detection algorithm ; deep learning ; venous thromboembolism ; medial collateral ligament ; strain ; video extensometer ; medial opening-wedge high tibial osteotomy ; central sensitization ; patient-reported outcomes ; osteotomy site pain ; minimal clinically important difference ; human umbilical cord blood derived mesenchymal stem cells ; cartilage regeneration ; cartilage repair ; osteoarthritis treatment ; stem cell therapy ; Outerbridge ; degeneration ; spacer block ; intramedullary rod ; femorotibial congruence ; unicompartmental arthroplasty ; osteoarthritis ; cartilage ; stem cells ; umbilical cord blood ; femur fracture ; polyethylene insert ; osteoporosis ; multivariate logistic analysis ; atelocollagen ; microfracture ; ACIC ; bone marrow aspirate concentrate ; human umbilical cord blood-derived mesenchymal stem cells ; knee osteoarthritis ; loosening ; arthroplasty ; machine learning ; transfer learning ; review ; prosthesis ; meniscus root ; medial meniscus posterior root ; medial meniscus posterior root tear ; meniscus root repair ; transtibial pull-out repair ; bone tunnel enlargement ; anterior cruciate ligament reconstruction ; landmark ; lateral tibial spine ; anatomy ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Over the years, digestive endoscopy has gone through a revolution. With different technological improvements, its diagnostic role is indeed becoming more and more sophisticated and is even moving closer to pathological evaluation. Above all, its therapeutic purpose is to date the first line of treatment for several gastrointestinal diseases. Importantly, the role of digestive endoscopy is also crossing over the mere concept of the GI tract and digestive diseases and will probably find a place in a more holistic concept of health. In this Special Issue, several emerging techniques are addressed, highlighting how endoscopy is emerging as a minimally invasive treatment procedure for several gastrointestinal diseases and post-surgical complications. However, crucial to this is the safety of all endoscopic processes, starting from endoscopic suites to the management of intra- and post-procedural complications.
    Keywords: interventional endoscopy, ERCP, cholangioscopy, biliopancreatic endoscopy, CH-EUS, radiofrequency ablation, necrosectomy, locoregional treatment, bariatric endoscopy, artificial intelligence ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Modern medical imaging systems provide information about the patient's health condition. Their precision, resolution and sensitivity are increasing, and new possibilities of differentiating the condition of tissue are constantly appearing. These advances are also taking place in musculoskeletal imaging. Increasingly accurate imaging in various modalities allows us to discover new relationships between the image and the diagnosis. It is therefore important to use all this information to best serve the patient. That is why research related to the analysis of medical images is so important, because it allows us to indicate what is invisible to the naked eye or to quantify what has so far been measured by humans or subject to discretionary assessment. This collection includes 25 works related to the analysis of images created during diagnostics of the musculoskeletal system using various modalities—from X-ray and fluoroscopy to conventional or spectral computed tomography, magnetic resonance imaging, ultrasound, elastography, PET/CT and systems for analyzing patient mechanics. Research was carried out related to the detection of various conditions, parameterization of clinical and population phenomena, and detection of image–clinical condition relationships. Despite the current popularity of machine learning techniques, the collection is dominated by classic engineering methods related to image processing. Several works use textural analysis, which has not been appreciated so far, which is particularly related to the imaging of the structure, especially of bones.
    Keywords: bone imaging, musculoskeletal imaging, image processing, image analysis, segmentation, textural analysis, machine learning ; bic Book Industry Communication::M Medicine
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    Taylor & Francis | Maintenance and Philosophy of Technology | Routledge
    Publication Date: 2024-04-05
    Description: What can we learn about the nature of technology by studying practices of maintenance and repair? This volume addresses this question by bringing together scholarship from philosophers of technology working at the forefront of this emerging and exciting topic. The chapters in this volume explore how attending to maintenance and repair can challenge and complement existing ways of thinking about technology focused on use and design and introduce new philosophical perspectives on the relationship between technology, time and human practice. They examine the significance of maintenance and repair practices at different scales in relation to a diverse range of philosophical traditions and a wide variety of technologies, from urban infrastructure such as bridges and buildings to data technologies such as servers and software systems. Together, the contributions highlight common themes in the philosophical study of maintenance, including the role of skill, the significance of social values and the potential of these practices to transform the technologies to which they are applied. By reflecting on the different ways in which we keep technologies going, from the devices we use in our homes to the large technical systems which surround us, this volume reveals the philosophical significance of practices of maintenance, not only as a source of new insights but also as a resource for enriching our understanding of a variety of existing topics in philosophy. Maintenance and Philosophy of Technology will appeal to scholars and advanced students working in philosophy of technology, philosophy of engineering and science & technology studies.
    Keywords: Mark Thomas Young,Mark Coeckelbergh,philosophy of technology,philosophy of engineering,maintenance,repair,skill,infrastructure,function,value structure,artifacts,consumption,utilization,fragility,trustworthiness,housing,sustainability,disposability,inbuilt obsolescence,urban aesthetics,maintenance as care,data,AI maintenance,software maintenance ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDA Philosophy of science ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
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    ANU Press | ANU Press
    Publication Date: 2024-04-08
    Description: Sanskrit narrative is the lifeblood of Indian culture, encapsulating and perpetuating insights and values central to Indian thought and practice. This volume brings together eighteen of the foremost scholars across the globe, who, in an unprecedented collaboration, accord these texts the integrity and dignity they deserve. The last time this was attempted, on a much smaller scale, was a generation ago, with Purāṇa Perennis (1993). The pre-eminent contributors to this landmark collection use novel methods and theory to meaningfully engage Sanskrit narrative texts, showcasing the state of contemporary scholarship on the Sanskrit epics and purāṇas.
    Keywords: Sanskrit ; Epics ; Puranas ; Ramayana ; Mahabharata ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-08
    Description: The book aims to set out in which respects concepts are properly studied in philosophy, what methodological role the study of concepts has in philosophy's study of the world, why there are several viable methods of analysis and even conceptual analysis has its place here. Many of the considerations in this book nowadays are placed under the headline 'metaphilosophy'. The book starts with some bold theses in favour of a representationalist theory of meaning and concepts which serve as the background for the discussion in the following chapters. In contrast to paradigmatic ordinary language philosophy the book endorses a representationalist theory of meaning and concepts, thus agreeing with many of its critics in philosophy and the cognitive sciences. In contrast to many of these critics and supposedly the majority of cognitive scientists it endorses the viability of conceptual analysis as one method of philosophy. The book reflects on Frege's theory of concepts, because Frege's theory of concepts was one strand that inaugurated analytic philosophy. Frege's theory of sentential unity has barely been superseded, and the problems arising from Frege's understanding of concepts are still alive. Frege's theory and the related problems in Frege's logic as in the Grundgesetze der Arithmetik (most famously the antinomy known as 'Russell's Paradox' going back to Frege's 'Basic Law V') lead over to considering the proper approach to our concept of logic and the issue of psychological and ontological realism in logic and mathematics. The central part of the book starts by reconsidering the approach and the idea of ordinary language philosophy and its understanding of conceptual analysis. Although ordinary language philosophy cannot be the whole of analytic philosophy a proper understanding of conceptual analysis turns out to be one part of analytic philosophy. This part starts with a general discussion of ordinary language philosophy, but proceeds then by a methodological overview and attempts to engage in some ordinary language philosophy concerning epistemological topics.
    Keywords: Begriffe ; Begriffsanalyse ; Metaphilosophie ; Philosophie der Normalen Sprache ; Philosophie der Logik ; bic Book Industry Communication::H Humanities::HP Philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPK Philosophy: epistemology & theory of knowledge ; bic Book Industry Communication::H Humanities::HP Philosophy::HPL Philosophy: logic ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTK Philosophy: epistemology and theory of knowledge ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTL Philosophy: logic
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Pain biomarkers are biological indicators or measurable characteristics that can provide information about the presence, severity, or underlying mechanisms of pain. They are valuable for several reasons: Diagnosis and differential diagnosis: Biomarkers can help in the diagnosis of various pain conditions and differentiate between different types of pain, such as neuropathic, inflammatory, or nociceptive pain. This can lead to more accurate and timely diagnoses, which in turn can improve patient care. Monitoring treatment efficacy: Pain biomarkers can be used to track how well treatments are working for individuals suffering from chronic pain conditions. This allows healthcare providers to make informed decisions about adjusting treatment plans, optimizing pain management, and avoiding unnecessary or ineffective interventions. Drug development and testing: Biomarkers play a crucial role in the development of new pain medications and therapies. They can help researchers identify potential drug targets, screen compounds for their pain-relieving properties, and assess the safety and efficacy of experimental treatments in clinical trials. Personalized medicine: Pain biomarkers may, in a future, contribute to treatments, tailored to an individual's unique genetic and biological disposition. Reducing opioid misuse: By using biomarkers to assess pain and treatment responses, healthcare providers can make more informed decisions about opioid prescriptions, potentially reducing the overuse and abuse of these medications.
    Keywords: analgesia ; biomarker ; CSF ; cytokine ; inflammation ; neuropathy ; neurotransmitter ; pain ; QoL ; sensitization ; sensory ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Logos Verlag Berlin | Logos Verlag Berlin
    Publication Date: 2024-04-05
    Description: The texts in this collection are revised versions of presentations given at the Coimbra International Conference on the Semantics of Culture emph Why ``Culture''?, held on November 24-25, 2011. Their common theme is the idea that the phenomenon of culture cannot be reduced to a substantialist vision of the diversity of manifestations of society and human beings. However, if one were to accept the concept of culture as a starting point for observing these manifestations, then it should also be adopted as a starting point for critical questioning, that is, for problematizing. The texts in this volume contribute to this philosophical problematization by pointing out - each with its own perspective of analysis - articulations of the phenomenon of culture as a theoretical object and as a thematic object.
    Keywords: Kultur / Culture ; Multikulturalität ; National Philosophies ; Comparative Studies ; Kulturphilosophie ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue focuses on the comprehensive understanding and novel treatments in the realm of cornea and ocular surface diseases. Ranging from the relatively benign manifestations of keratoconjunctivitis sicca to more critical conditions such as corneal ulcers, ocular surface diseases pose a considerable challenge in clinical ophthalmology. Such conditions can severely compromise the transparency of the cornea, often necessitating interventions such as keratoplasty. A significant emphasis of this edition is on the paramount importance of pre-surgical optimization. A successful keratoplasty is often predicated on the health of the ocular surface. Through a series of insightful articles, the importance of enhancing tear function, rehabilitating the normal lid anatomy, and ensuring a robust limbal stem cell supply is elucidated. Properly addressing these factors has a direct bearing on the success rate of the subsequent surgical intervention. Another highlight of this Special Issue is the presentation of cutting-edge treatments. Researchers from around the globe share their findings, detailing advancements in both surgical and non-surgical treatments. These range from innovative surgical techniques and tools to groundbreaking pharmaceutical agents that hold promise in managing and possibly reversing some of these conditions. In summary, this Special Issue serves as a repository of the latest knowledge in the management of cornea and ocular surface diseases, aimed at both the seasoned ophthalmologist and budding researchers in the field.
    Keywords: cornea ; ocular surface disease ; dry eye ; corneal ulcer ; keratoplasty ; bic Book Industry Communication::M Medicine
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    Publication Date: 2024-01-08
    Description: This reprint, entitled “Management of Acute and Chronic Complications of Lysosomal Storage Diseases in Children and Adults: Current Practice and Future Opportunities”, covers broad aspects of this group of rare diseases. The first theme includes articles on the management of pain, corneal clouding, gastrointestinal and airway diseases in Mucopolysaccharidoses and Mucolipidoses, and the evaluation of dysphonia in Pompe disease. Additionally, attention deficit and ADHD and the management of atherosclerosis in Fabry disease are considered here. The second theme includes diagnostic conundrums in lysosomal storage diseases, e.g., the prenatal diagnosis of Gaucher disease during pregnancy, the diagnosis of secondary hyperparathyroidism in Mucolipidoses, and the application of the new biomarker “plasma neurofilament light” in Niemann Pick C disease, as well as the correlation of enzyme activity with molecular diagnosis in Pompe disease. The articles in the third theme describe the impact of therapies on clinical outcomes. For example, a systematic review of the impact of enzyme replacement therapy on late-onset Pompe disease and trehalose use on Niemann Pick A and B is included. The remaining articles describe the NHS processes for overcoming challenges resulting from the COVID-19 pandemic and the differences in the transition from paediatric to adult services between different countries.
    Keywords: Mucopolysaccharidosis ; corneal clouding ; penetrating keratoplasty ; deep anterior lamellar keratoplasty ; mucopolysaccharidoses ; airway ; obstruction ; management ; Fabry disease ; attention ; Attention Deficit/Hyperactivity ; cognition ; late-onset Pompe disease ; gastrointestinal ; smooth muscles ; PROMIS–GI symptom scales ; GAAKO mice ; glycogen storage disorder ; translational research ; patient-reported outcomes measures ; mucopolysaccharidosis ; MPS ; disease manifestations ; symptoms ; morbidity ; spine disease ; anaesthesia ; perioperative complications ; surgery ; pompe disease ; speech ; voice ; dysphonia ; acoustic ; auditory-perceptual ; GRBAS ; respiratory ; Pompe disease ; gene panel sequencing ; alpha-glucosidase ; GAA ; dried-blood spots ; fabry disease ; neuropathic pain ; depression ; Fabry ; atherosclerosis ; ischaemia ; perfusion ; angina ; Sanfilippo syndrome ; mortality ; Niemann–Pick C ; neurofilament light ; biomarkers ; neurological disease ; glycogen storage disease type II ; enzyme replacement therapy ; COVID-19 ; inherited metabolic disorders ; rare autoinflammatory diseases ; health care providers ; Gaucher disease ; NIHF ; perinatal-lethal Gaucher disease ; PLGD ; ichthyosis ; GBA gene ; airway management ; radiology ; hyoid bone ; chin ; intubation ; intratracheal ; lysosomal storage disease (LSD) ; Niemann–Pick type A ; Niemann–Pick type B ; acid sphingomyelinase ; sphingolipid deposition ; trehalose ; mucolipidosis type II ; ML II ; I-cell disease ; hyperparathyroidism ; mucolipidosis ; ML ; MLII ; transition service ; adult metabolic medicine ; collaboration ; challenges ; inherited metabolic diseases ; healthcare systems ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Molecular toxicology is a field that investigates the interactions between chemical or biological molecules and organisms at the molecular level. In this Special Issue, we focus on the toxic effects and mechanisms of action of chemical and biological molecules, will be of great interest of readers in molecular toxicology and applied pharmacology.
    Keywords: smoking ; inflammatory ; cytokine ; human serum ; GO ; PRRSV ; FT-SPR ; sensitization ; NNK ; nicotine ; cytotoxicity ; genotoxicity ; cytochrome P450 2A13 ; Aspergillus flavus ; aflatoxins B1 ; carcinogen ; Surface-Enhanced Raman Scattering ; colloidal Au nanoparticles ; portable Raman spectrometer ; Euphorbia semen ; Euphorbia factors ; transcriptome ; RNA sequencing ; bioinformatics ; gene structure ; neuroblast differentiation-associated protein AHNAK ; hepatocellular carcinoma (HCC) ; insulin-like growth factor 1 receptor (IGF-1R) ; interactome ; field cancerization ; 8–17 DNAzyme ; gene silencing ; catalysis ; antisense ; chemical modifications ; 6-cyclohexyl methyl-β-D-maltoside ; transduction efficiency ; conditionally replicative adenovirus ; lethal effect ; gene therapy ; PBDE ; immunotoxicity ; macrophage ; reactive oxygen species ; apoptosis ; immune function ; breast cancer ; signature ; aging ; cancer ; nomogram ; immunotherapy ; tumor mutation burden ; doxorubicin ; Toll-like receptor 4 ; cardiotoxicity ; heart ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, we have gathered high-level research papers from all over the world. We would like to thank all researchers for their commitment to the field. From diagnostic ultrasound of different fetal conditions to advanced cardiovascular imaging leading to fetal MRI and from serum markers and biomarkers in maternal and fetal conditions to new modalities in fetal therapy, this Special Issue covers a large scale view of the present spectrum of modern perinatal medicine. Again, a warm thank you to all contributors.
    Keywords: fetal echocardiography ; fetal abnormalities ; fetal therapy ; genetic testing, prenatal medicine ; bic Book Industry Communication::M Medicine
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    transcript Verlag | transcript Verlag
    Publication Date: 2024-04-08
    Description: Robots as social companions in close proximity to humans have a strong potential of becoming more and more prevalent in the coming years, especially in the realms of elder day care, child rearing, and education. As human beings, we have the fascinating ability to emotionally bond with various counterparts, not exclusively with other human beings, but also with animals, plants, and sometimes even objects. Therefore, we need to answer the fundamental ethical questions that concern human-robot-interactions per se, and we need to address how we conceive of »good lives«, as more and more of the aspects of our daily lives will be interwoven with social robots.
    Keywords: Ethics ; Robots ; Friendship ; Society ; Technology ; Philosophy of Technology ; Sociology of Technology ; Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The topics covered in this Special Issue range from breastfeeding and early-life nutrition to effects on microbiota, infection, allergy, asthma, and the mechanisms of immunomodulation via (the early introduction of) nutrition on infections and the development of (food) allergies.
    Keywords: diet ; pregnancy ; cord blood ; fatty acids ; n-3 PUFAs ; n-6 PUFAs ; arachidonic acid ; phospholipids ; atopic eczema ; NICE birth cohort ; multi-allergen ; early introduction ; food allergy ; safety ; efficacy ; prevention ; allergic sensitization ; foetal immune ontogeny ; gene/environment interactions ; asthma ; eczema ; maternal diet ; PUFAs ; vitamin D ; Mediterranean diet ; microbiome ; breastfeeding ; functional gastrointestinal disorder ; partial hydrolysate ; peptide ; protein ; infancy ; childhood ; immune development ; probiotic ; microbiota ; allergy ; atopic dermatitis ; breastmilk ; house dust mite ; Der p 1 ; Asthma ; total IgE ; atopy ; sensitization ; oral tolerance ; early food introduction ; milk protein ; cow’s milk allergy (CMA) ; maternal atopy ; epigenetics ; pediatric asthma ; cohort study ; immune complex ; trained immunity ; RSV ; bovine IgG ; preF protein ; cow’s milk allergy ; allergen ; hypoallergenic infant formula ; n/a ; IgA deficiency ; selenium deficiency ; zinc deficiency ; recommended dietary allowances ; immune system ; allergen molecules ; milk allergen micro-array ; peptides ; anaphylaxis ; milk tolerance ; diagnosis ; IgE sensitization ; children ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Helicobacter pylori is one of the most common infections in the world, affecting roughly half of all humans. Although it is not an infection that causes death immediately after infection, it is one of the largest emerging infectious diseases in the history of humankind, causing a wide variety of diseases and, in the long term, serious complications such as stomach cancer. This Reprint contains empirical studies and reviews regarding the diagnosis, treatment, complications, and management of H. pylori infection, including new diagnostic methods, effective eradication regimens, the management of gastric cancer, and other topics.
    Keywords: gastric cancer ; biliopancreatic reflux ; gastritis ; carcinoma ; endoscopic surveillance ; Helicobacter pylori infection ; gastric stump cancer ; Helicobacter pylori ; H. pylori ; rifabutin ; treatment ; eradication failure ; culture ; bismuth ; rescue ; Hp-EuReg ; third-generation ultrathin endoscope ; transnasal endoscopy ; narrow-band imaging ; Kyoto classification of gastritis ; gastric atrophy and intestinal metaplasia ; diagnosis ; stool antigen test ; urea breath test ; peptic ulcer disease ; triple therapy ; vonoprazan ; dyspepsia ; Kyoto Classification of Gastritis ; cagA ; Okinawa ; endoscopic findings ; Helicobacter infection ; tetracycline ; eradication ; penicillin allergy ; furazolidone ; metronidazole ; amoxicillin ; child ; host genetic factor ; iron deficiency anemia ; iron demand ; iron uptake ; sports activity ; virulence factor ; gastric lymphoma ; MALT lymphoma ; radiotherapy ; chemotherapy ; rituximab ; dual therapy ; vonoprazan (VPZ) ; amoxicillin (AMOX) ; clarithromycin (CAM) ; bic Book Industry Communication::M Medicine
    Language: English
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  • 39
    Publication Date: 2024-04-08
    Description: The articles assembled in this volume present an important selection of Professor Jao Tsung-i’s research in the field of the early Chinese intellectual tradition, especially as it concerns the human condition. Whether his focus is on myth, religion, philosophy or morals, Jao consistently aims to describe how the series of developments broadly associated with the Axial Age unfolded in China. He is particularly interested in showing how early China had developed its own notion of transcendence as well as a system of prediction and morals that enabled man to act autonomously, without recourse to divine providence.
    Keywords: Axial Age ; early China ; ancient China ; transcendence ; Hemerology ; Astrology ; Correlative Thought ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRR Other religions and spiritual beliefs::QRRT Indigenous, ethnic and folk religions and spiritual beliefs::QRRT1 Indigenous religions, spiritual beliefs and mythologies of the Americas ; thema EDItEUR::1 Place qualifiers::1F Asia::1FP East Asia, Far East::1FPC China ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRR Other religions and spiritual beliefs::QRRT Indigenous, ethnic and folk religions and spiritual beliefs::QRRT1 Indigenous religions, spiritual beliefs and mythologies of the Americas ; thema EDItEUR::1 Place qualifiers::1F Asia::1FP East Asia, Far East::1FPC China
    Language: English
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  • 40
    Publication Date: 2024-02-27
    Description: Collective monograph contains the results of scientific research devoted to new views and proposals for the diagnosis of certain diseases. The proposed solutions are important for clinical practice and inspire optimism in obtaining encouraging results in overcoming some pathologies. Chapter 1 is dedicated to endoscopic retrograde cholangiopancreatography - a contrast study of the bile ducts and ductal system of the pancreas, which is achieved by their cannulation with the help of a flexible endoscope and their visualization by X-ray (fluoroscopy). Thanks to this, it becomes possible to diagnose and perform medical interventions for choledocholithiasis, benign and malignant obstruction of the bile ducts, chronic pancreatitis accompanied by obstruction of the pancreatic ducts. Chapter 2 presents the results of the development of a thermoelectric device for diagnosing inflammatory processes and pain syndrome in degenerative-dystrophic diseases of the lumbosacral spine. Such a device makes it possible to save, process and visualize measurement results on the display of the device and on a personal computer in real time. The results of clinical studies of thermometric indicators in the lumbosacral region of the spine in persons with chronic pain syndrome against the background of degenerative-dystrophic pathology of the spine in the presence of hernias and protrusions of intervertebral discs are given. The effectiveness of the proposed thermoelectric device in medical practice has been confirmed. Chapter 3 presents the results of the examination of various contingents of the population: students, athletes, mobile operators, people with hearing loss, post-covid syndrome and psychophysiological lability developed under martial law. The features of information processing by examinees with different degrees of functional mobility of nervous processes are highlighted. It was found that the deprivation of auditory function, post-conviction syndrome, psychophysiological lability developed in the conditions of martial law significantly reduce the level of neural processes and the ability to process information. The evaluation scales of neurodynamic and sensorimotor functions proposed for use in the medical field can be used to optimize diagnosis and increase the effectiveness of monitoring neurological morbidity, including in people with special needs. Chapter 4 is devoted to the problems of children's neuropsychiatric diseases, in particular brain damage in children with ASD. Restrained optimism is expressed for the prospect of overcoming this severe psychiatric pathology in the foreseeable future due to the introduction of genetic, biochemical and immunodiagnostic approaches, as well as metabolic and immunotherapeutic interventions with neuroprotective effects. Arguments are presented in favor of the fact that the successful testing in clinical practice of evidence-based personalized multidisciplinary strategies of diagnosis and treatment will allow a breakthrough in the clinical management of children with severe mental disorders in the near future. This will provide not only the possibility of recovery from a prognostically unfavorable and currently incurable neuropsychiatric disorder, but will also contribute to stopping the large-scale threatening epidemic of neuropsychiatric syndromes in the modern child population. Chapter 5 presents the evolution of views on the problem of Internet addiction, provides information on its prevalence, comorbidity with mental disorders, and provides an overview of modern clinical classifications and psychometric tools for its diagnosis. A single definition of "cyber addiction" is singled out, based on the fact that the object of addiction is interaction with various information resources and technical means. The proposed clinical diagnostic criteria, which are based on the criteria for the diagnosis of mental and behavioral disorders due to the use of psychoactive substances ICD-11, and the characteristics of the boundary with normative behavior when using various information resources and technical means are provided. The development and validation of a new psychodiagnostic screening tool based on the proposed cyber addiction paradigm, the YSCAS scale, is presented. The monograph is intended for doctors and practitioners who are engaged in the search and implementation of effective diagnostic methods to overcome the problems associated with the detection and treatment of certain pathologies. The monograph can also be useful to postgraduate and master's students of universities in the relevant educational and scientific profile.
    Description: Published
    Keywords: Endoscopic retrograde cholangiopancreatography ; Endoscopic lithoextraction ; Osteochondrosis of the spine ; Thermoelectric device ; Individual-typological properties ; Functional mobility ; Sensorimotor reactivity ; Autism spectrum disorders ; Attention deficit hyperactivity disorder ; Obsessive-compulsive syndrome ; Immunodiagnostics ; Internet addiction ; Cyberaddiction ; YSCAS scale ; bic Book Industry Communication::M Medicine
    Language: English
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    UCL Press
    Publication Date: 2024-04-11
    Description: The Correspondence of Jeremy Bentham, Volume 13 contains authoritative and fully annotated texts of all known and publishable letters sent both to and from Bentham between 1 July 1828 and his death on 6 June 1832. In addition to 474 letters, the volume contains three memorandums concerning Bentham’s health shortly before his death, his Last Will and Testament, and extracts from both the Autobiography and the manuscript diaries of Bentham’s nephew George. Of the letters that have been previously published, most are drawn from the edition of The Works of Jeremy Bentham, prepared under the superintendence of Bentham’s literary executor John Bowring. A small number of letters have been reproduced from newspapers and periodicals. This volume publishes for the first time all the extant correspondence between Bentham and Daniel O’Connell, the Irish Liberator. Other new acquaintances included Charles Sinclair Cullen, barrister and law reformer, and John Tyrrell, the Real Property Commissioner. Throughout the period, Bentham maintained regular contact with old friends and connections, but he also entered into sporadic correspondence with such leading figures in government as the Duke of Wellington, Robert Peel and Henry Brougham. Further afield, Bentham corresponded, amongst others, with the Marquis de La Fayette in France, Edward Livingston in the United States of America and José del Valle in Guatemala.
    Keywords: Bentham;correspondence;letters;diaries;autobiography;memorandums;Irish Liberation;July Revolution;codification;legal thought;legal ideas;philosophy;Benthamite utilitarianism;utilitarianism;chemistry;botany;legal reform;law;literature;Nineteenth century;George Bentham;The Works of Jeremy Bentham;John Bowring;Daniel O’Connell;Charles Sinclair Cullen;John Tyrrell;Duke of Wellington;Robert Peel;Henry Brougham;Marquis de La Fayette;Edward Livingston;José Del Valle ; thema EDItEUR::D Biography, Literature and Literary studies::DN Biography and non-fiction prose::DND Diaries, letters and journals ; thema EDItEUR::L Law::LA Jurisprudence and general issues ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint focuses on the importance of the micronutrient iron in human physiological iron homeostasis and iron-related diseases. Daily adequate dietary iron supply ensures vital body functions and hemoglobin synthesis during erythropoiesis. During the last few decades, scientific evidence has shown that the maintenance of human iron homeostasis is an important factor for physical and mental health. The present reprint gives an overview of how iron, as an essential dietary element, is responsible for physiological and pathological biochemical processes in the human body. For the readership, this relevant information will provide an evidence-based update on the complex regulatory mechanisms and related diseases of iron metabolism.
    Keywords: iron metabolism ; iron homeostasis ; micronutrient iron ; physiology ; pathology ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 43
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    Open Book Publishers
    Publication Date: 2024-04-08
    Description: 'Tener demasiado' es el primer volumen académico dedicado al limitarismo: la idea de que el uso de los recursos económicos o de los ecosistemas no sobrepasen ciertos límites. Se trata de un concepto profundamente arraigado en el pensamiento económico y político, por lo que es posible encontrar premisas similares en pensadores como Platón, Aquino o Spinoza. No obstante, 'Tener demasiado' es el primer ejemplar en el campo de la filosofía política contemporánea en el que el limitarismo se explora en profundidad y con detalle. Asimismo, este estudio reúne por primera vez los mejores escritos de los principales teóricos del limitarismo, lo que le convierte en una contribución esencial al campo de la filosofía política, en general, y de las teorías sobre la justicia distributiva, en particular. Incluye tanto artículos seminales ya publicados como nuevos capítulos y se presenta como lectura indispensable para académicos y estudiantes de teoría política y filosofía, así como para todos aquellos interesados en cuestiones relacionadas con la justicia distributiva.
    Keywords: Limitarismo;Recursos materiales;Limitarismo económico;Limitarismo ecológico;Generaciones futuras;Justicia distributiva;Justicia intergeneracional ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHR Western philosophy from c 1800 ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCA Economic theory and philosophy ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNA Environmentalist thought and ideology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHR Western philosophy from c 1800 ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCA Economic theory and philosophy ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNA Environmentalist thought and ideology
    Language: English , Spanish
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-07
    Description: What can we learn about the nature of technology by studying practices of maintenance and repair? This volume addresses this question by bringing together scholarship from philosophers of technology working at the forefront of this emerging and exciting topic. The chapters in this volume explore how attending to maintenance and repair can challenge and complement existing ways of thinking about technology focused on use and design and introduce new philosophical perspectives on the relationship between technology, time and human practice. They examine the significance of maintenance and repair practices at different scales in relation to a diverse range of philosophical traditions and a wide variety of technologies, from urban infrastructure such as bridges and buildings to data technologies such as servers and software systems. Together, the contributions highlight common themes in the philosophical study of maintenance, including the role of skill, the significance of social values and the potential of these practices to transform the technologies to which they are applied. By reflecting on the different ways in which we keep technologies going, from the devices we use in our homes to the large technical systems which surround us, this volume reveals the philosophical significance of practices of maintenance, not only as a source of new insights but also as a resource for enriching our understanding of a variety of existing topics in philosophy. Maintenance and Philosophy of Technolog will appeal to scholars and advanced students working in philosophy of technology, philosophy of engineering and science & technology studies.
    Keywords: Mark Thomas Young,Mark Coeckelbergh,philosophy of technology,philosophy of engineering,maintenance,repair,skill,infrastructure,function,value structure,artifacts,consumption,utilization,fragility,trustworthiness,housing,sustainability,disposability,inbuilt obsolescence,urban aesthetics,maintenance as care,data,AI maintenance,software maintenance ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDA Philosophy of science ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDR Impact of science and technology on society
    Language: English
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  • 45
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue addresses recent advances in the research of plant-derived natural products, their mechanisms of action and how they can influence health and disease. Plant-derived natural products have been well known since antiquity due to their beneficial effects on human health, and since then, they have attracted the interest of the scientific community, leading to the identification, isolation and quantification of their compounds and research on their biomedical properties. They have been found to be rich in phytochemicals, such as terpenes and phenolic compounds, with proven antioxidant, anti-inflammatory, antimicrobial, antitumor and prebiotic properties, and therefore, they have been suggested as potential candidates for the therapeutic management of several chronic diseases. Some of them include inflammatory bowel disease, diabetes, non-alcoholic fatty liver disease, arthritis and cancer, in which inflammation, oxidative stress and dysbiosis mechanisms are implicated. Furthermore, given the increased economic burden, the side effects and the low compliance rates of patients who receive standard medical treatments, plant-derived natural products could possibly serve as adjunct therapeutic agents for chronic diseases.
    Keywords: plants ; natural products ; free radicals ; inflammation ; medicinal ; caffeic acid ; antibacterial ; antifungal ; antioxidant ; anticancer ; juglone ; Juglans regia ; mogrol ; mogroside ; phytochemical ; pharmacology ; osteoporosis ; antiobesity ; anti-inflammation ; neurodegenerative disorders ; anticancer agents ; aromadendrane ; bryophytes ; cytokinesis inhibitor ; Plagiochila species ; plagiochilins ; analgesic activity ; traditional medicine ; wound healing ; colon carcinogenesis ; 1,2 dimethylhydrazine ; hesperetin ; capecitabine ; Jatropha tanjorensis ; Fraxinus micrantha ; HPTLC ; anti-obesity activity ; high-fat diet model ; histological ; Alzheimer ; acetylcholinesterase inhibitors ; Euonymus laxiflorus Champ. ; bioactive compounds ; medicinal plants ; P. lentiscus ; GC/MS ; HPLC-DAD ; antioxidant activity ; antibacterial activity ; antifungal activity ; extract ; molecular docking ; Artemisia arborescens ; Artemisia inculta ; phenolic compounds ; terpenes ; trace metals ; antioxidant capacity ; Eurycoma longifolia Jack ; anti-inflammatory ; antinociceptive effect ; antipyretic effects ; gastroprotective activity ; gastric ulcer ; Thai traditional medicine ; phytochemicals ; inflammatory bowel disease ; gut microbiota ; Mastiha ; Curcumin ; Boswellia serrata ; Artemisia absinthium ; lipidomic profile ; Tulsi ; Ocimum sanctum ; ischemic stroke ; photothrombotic ischemia ; medicinal plant ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Translational research is required to uncover the underlying pathomechanisms of neurological and psychiatric disorders, search for new biomarkers, and develop novel therapeutics. Complex polygenic, multifactorial, and heterogeneous mechanisms have been elucidated using in vivo and in vitro models. Advanced preclinical models have recently revealed an intriguing interaction between sex/gender and aging in the pathogenesis and clinical manifestations of neuropsychiatric disorders. Despite these advances, much work remains to be carried out to fully understand the underlying pathology of these conditions and to develop treatments that can significantly improve the lives of those who suffer from them. The current challenge in the field of neurological and psychiatric disorders is the development of disease-modifying, effective treatments for these complex and long-term debilitating conditions with a high malady burden. The first edition of this research topic, entitled 'Emerging Translational Research in Neurological and Psychiatric Diseases: From In Vitro to In Vivo Models,' emphasizes the importance of translational research in bridging the gap between basic research and clinical applications. Furthermore, it provided a venue for researchers to share their findings and progress in translational research in this field.
    Keywords: Alzheimer&rsquo ; s disease ; Parkinson&rsquo ; multiple sclerosis ; stroke ; migraine ; pain ; depressive disorder ; anxiety disorder ; autism spectrum disorder ; sleep wake disorders ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: undefined
    Keywords: Medicine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 48
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Various classes of natural and synthetic molecules that can be classified as biomaterials find application in all fields of dentistry. Biomaterials should be biocompatible to minimise toxicity and bioactivity to ensure or simulate biological effects. They are used, for instance, to enhance antibacterial activity and improve the healing process. Calcium silicates, for illustration, are biomaterials used in endodontics that have proven their excellent biological, physico-chemical, and mechanical properties. However, some of these are considered too soluble, and this is almost completely due to their hardness when used as endodontic sealers, making endodontic retreatment very difficult. Despite manufacturers' best efforts, it is sometimes difficult to marry bioactivity, biocompatibility, and clinical benefits in a biomaterial; therefore, in this content, the work of researchers is invaluable.
    Keywords: calcium silicate cement ; retrograde materials ; premixed cement ; powder–liquid cement ; chemical composition ; EDX ; caries prevention ; anterior restorations ; ceramic ; dental veneers ; follow-up ; non-vital teeth ; porcelain laminate veneers ; vital teeth ; antimicrobial ; osseointegration ; surface modification ; tissue engineering ; root canal retreatment ; calcium silicate-based cement ; ProTaper Universal Retreatment ; D-Race ; dentin hypersensitivity ; desensitizing agents ; calcium phosphate ; hydroxyapatite ; nano-hydroxyapatite ; peri-implantitis ; periodontitis ; periapical radiograph ; deep learning ; neural networks ; image enhancement ; carious lesion activity ; irreversible pulpitis ; partial pulpotomy ; vital pulp therapy ; mineral trioxide aggregate ; furcation involvement ; image segmentation ; Gaussian high-pass filtering ; image preprocessing ; CNN ; calcium silicate material ; confocal laser scanning microscope ; deciduous tooth ; digital microscopy ; flowability ; micro-CT ; pulpectomy primary teeth ; root canal filling ; SEM ; zinc oxide eugenol ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The healthcare system’s ability to diagnose and care for people with schizophrenia has improved in recent decades, as effective pharmacological and psychosocial interventions are now available. However, schizophrenia remains a leading cause of disability and premature mortality. The utilization of pharmacological and psychosocial interventions in the healthcare system, which have the potential to significantly improve the quality of life for people with schizophrenia, heavily depends on medical professionals completing accurate and comprehensive assessments of patients’ psychopathologies, cognitive profiles, physical health statuses and any environmental factors that may influence them. This Special Issue reprint on schizophrenia, from the Journal of Clinical Medicine, presents a collection of articles on current approaches to assessment and treatment, as well as new findings and future perspectives of schizophrenia research and care.
    Keywords: schizophrenia ; ERP ; mismatch negativity ; MMN ; P3a ; illness duration ; real-life functioning ; motivation circuits ; negative symptoms ; RDoC ; positive valence system ; salience system ; deficit syndrome ; diagnosis ; cognitive function ; social skills training ; physical comorbidities ; childhood abuse ; internalized stigma ; neutrophil-to-lymphocyte ratio ; antipsychotics ; hypothyroidism ; inflammatory markers ; expressive deficits ; experiential deficits ; functioning ; quality of life ; first psychotic episode ; first episode ; emotional processing ; social cognition ; MCCB ; MSCEIT ; real-world studies ; real-world effectiveness ; tolerability ; treatment adherence ; second-generation antipsychotics ; long-acting injectable antipsychotics ; delusional disorders ; psychosis ; sex ; women ; psychopathology ; construct ; schizophrenia spectrum ; renaming ; rethinking ; revising ; effort expenditure ; recent-onset schizophrenia ; persistent negative symptoms ; motivation ; neuropeptide S ; cognitive functioning ; rehabilitation ; AEP ; QEEG ; switch ; extrapyramidal symptoms ; treatment ; cognitive deficits ; self-evaluation of negative symptoms ; health-related quality of life ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Brill
    Publication Date: 2024-04-06
    Description: The Crisis of Causality deals with the reaction of the Dutch Calvinist theologian Gisbertus Voetius (1589-1676) to the New Philosophy of René Descartes (1596-1650). Voetius not only criticised the Cartesian idea of a mechanical Universe; he also foresaw that shifting conceptions of natural causality would make it impossible for theologians to explain the relationship between God and Creation in philosophical terms. This threatened the status of theology as a scientific discipline. Apart from a detailed analysis of the Scholastic and Cartesian notions of causality, the book offers new perspectives on related subjects, such as seventeenth-century university training and the Cartesian method of science. It will be of great importance to any student of seventeenth-century intellectual history, philosophy, theology and history of science.
    Keywords: Aristotelian ; Calvinist ; cartesian ; church history ; Han van Ruler ; history ; ideas ; intellectual ; philosophy ; scholastic ; theology ; Thomistic ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies::JBCC9 History of ideas ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MG 17th century, c 1600 to c 1699
    Language: English
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    Oxford University Press
    Publication Date: 2024-04-08
    Description: This book is about mental imagery and the important work it does in our mental life. It plays a crucial role in the vast majority of our perceptual episodes. It also helps us understand many of the most puzzling features of perception (like the way it is influenced in a top-down manner and the way different sense modalities interact). But mental imagery also plays a very important role in emotions, action execution, and even in our desires. In sum, there are very few mental phenomena that mental imagery doesn’t show up in—in some way or other. The hope is that if we understand what mental imagery is, how it works and how it is related to other mental phenomena, we can make real progress on a number of important questions about the mind. This book aims at an interdisciplinary audience. As it aims to combine philosophy, psychology, and neuroscience to understand mental imagery, I have not presupposed any prior knowledge in any of these disciplines. As a result, readers with no background in any of these disciplines can also follow the arguments.
    Keywords: mental imagery, imagination, perception, philosophy, psychology, neuroscience ; bic Book Industry Communication::H Humanities::HP Philosophy::HPM Philosophy of mind ; bic Book Industry Communication::H Humanities::HP Philosophy::HPN Philosophy: aesthetics ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMR Cognition & cognitive psychology::JMRP Perception ; bic Book Industry Communication::H Humanities::HP Philosophy ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMR Cognition & cognitive psychology ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTM Philosophy of mind ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTN Philosophy: aesthetics ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMR Cognition and cognitive psychology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Collège de France
    Publication Date: 2024-04-08
    Description: Depuis une dizaine d’années, les recherches menées sur la nature de la connaissance philosophique, le défi de l’intégration, et la connaissance des essences se sont beaucoup enrichies. En faisant appel à des philosophes engagés sur ces sujets, cet ouvrage se donne pour ambition de faire le point sur ces recherches brûlantes et d’en dégager les perspectives. On s’interrogera sur les relations entre connaissance métaphysique et connaissance philosophique, sur la nature des essences et sur leur connaissance, sur les liens entre essences et modalités, sur la place que joue, pour élucider celles-ci, une réflexion sur l’essentialisme et sur les espèces naturelles, sans oublier la manière dont doit se faire l’articulation entre les formes a priori et a posteriori de la connaissance.
    Keywords: metaphysics ; epistemology ; epistemology of modality ; essence ; bic Book Industry Communication::H Humanities::HP Philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPJ Philosophy: metaphysics & ontology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTJ Philosophy: metaphysics and ontology
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: In 2020-2022, much of the world was at risk for catching COVID-19. This reprint, “Crimmigration in the Age of COVID-19,” contributes to understanding immigration during the pandemic. It engages a cross-national and interdisciplinary case-study approach to show how countries carved out exceptions to public health protocols for migrants. In the immigration context a variety of governments weaponized public health protocols to criminalize and exclude migrants. The Trump Administration sadistically misplayed the pandemic at almost every turn. Trump came to power on the backs of migrants, referring to them as murderers and rapists. The intersection of Trump’s COVID-19 and migration policies carved out space for the exceptional dehumanization of migrants in 2020-21. This reprint documents the weaponization of public through crimmigration. Crimmigration is the criminalization of migration and migrants via state-of-the-art surveillance and militarized technologies. During the worst of COVID-19, crimmigration strategies--mandatory detention and harsh exclusions— exacerbated the risk of transmission among migrants. Policies not migrants were to blame here. The ostensibly public health related Title42 actually pushed migrants, already at great risk, into unregulated shantytowns controlled by Mexican drug cartels. Additionally, migrants contended with detention facilities, medium security prisons, that functioned as Petrie dishes for the disease. We hope this reprint contributes to understanding the intersection of public health and crimmigration, and border penologies during these exceptional times.
    Keywords: coronavirus ; immigration detention ; migration enforcement ; detention abolition ; detention ; immigration ; human rights ; healthcare ; access to justice ; crimmigration ; deportation ; return ; COVID-19 ; pandemic ; securitisation ; threat prioritisation ; Australia ; New Zealand ; welfare ; exclusion ; surveillance ; attrition ; incarcergration ; decriminalization ; detention standards ; alternatives to detention ; conditions of detention ; COVID ; racial apathy ; white ignorance ; institutional legitimacy ; governing through migration ; The Netherlands ; discourse ; border practices ; asylum seekers ; economic migrants ; Poland ; pushbacks at the border ; COVID-19 pandemic ; governmental xenophobia ; migrants/refugees ; vaccination ; Greece ; n/a ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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    Open Book Publishers
    Publication Date: 2024-04-08
    Description: Having Too Much is the first academic volume devoted to limitarianism: the idea that the use of economic or ecosystem resources should not exceed certain limits. This concept has deep roots in economic and political thought. One can find similar statements of such limits in thinkers such as Plato, Aquinas, and Spinoza. But Having Too Much is the first time in contemporary political philosophy that limitarianism is explored at length and in detail. Bringing together in one place the best writing from key theorists of limitarianism, this book is an essential contribution to political philosophy in general, and theories of distributive justice in particular. Including some of the key published articles as well as new chapters, Having Too Much is necessary reading for scholars and students of political theory and philosophy, as well as anyone interested in questions of distributive justice.
    Keywords: limitarianism;material resources;economic limitarianism;ecological limitarianism;future generations;political thought;distributive justice;intergenerational justice ; bic Book Industry Communication::H Humanities::HP Philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPC History of Western philosophy::HPCF Western philosophy, from c 1900 - ; bic Book Industry Communication::H Humanities::HP Philosophy::HPS Social & political philosophy ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCA Economic theory & philosophy ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNA Environmentalist thought & ideology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHR Western philosophy from c 1800 ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCA Economic theory and philosophy ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNA Environmentalist thought and ideology
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    Mohr Siebeck | Mohr Siebeck GmbH & Co. KG
    Publication Date: 2024-04-08
    Description: Reflections on God, Christ and cosmos in the writings of Paul and the Pauline School show that these authors were familiar with important notions from Graeco-Roman cosmology and theology. George van Kooten comes to the conclusion that they might even have adopted a way of thinking in which Judaism and Graeco-Roman cosmology were forged into a new synthesis, and Christ was viewed as a cosmic god. In this development, Paul and the authors of the Pauline School took up various positions which were all represented in contemporary discussions about God and cosmos in the philosophical schools. Against this background this study also sheds new light on the specific relationship between Colossians and Ephesians.
    Keywords: Philosophy ; Religious ; Philosophy ; History & Surveys ; Philosophy ; Essays ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRA Religion: general::HRAB Philosophy of religion ; bic Book Industry Communication::H Humanities::HP Philosophy::HPC History of Western philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAB Philosophy of religion ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    University of Hawai'i Press
    Publication Date: 2024-03-26
    Description: From Sung times, and throughout the Ming period, one of the dominant philosophies of China had been a dualistic rationalism thought to be firmly grounded on the classics. Tai Chen (1723-1777) was a scholar and philosopher during the Ch'ing period- a time when China produced few philosophic thinkers. He was the greatest of these, and his views are embodied chiefly in Yuan Shan and in Meng Tzu txu-yi shu-cheng. In place of the prevailing Sung dualism, Tai Chen propounded a rationalistic monism seldom before insinuated in a Chinese philosophy. He declines to accept current dogmas and preferred to seek his own truths. His commentaries opposed the time-honored interpretations of Chu Hsi, and he discredited them on purely philosophical grounds. But with few disciples to carry on his teachings, he was virtually forgotten or ignored in China for more than a hundred years after his death. It was not until early in the present century- with China under the pressures of Western aggression and internal disorders-that Tai Chen's nearness to Western thought was rediscovered and his important role in the history of philosophy recognized. Curiously, this first of China's Western-oriented philosophers even today remains little known in the West and his major writings largely untranslated.
    Keywords: Philosophy ; History ; thema EDItEUR::D Biography, Literature and Literary studies::DN Biography and non-fiction prose::DNB Biography: general ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDH Philosophical traditions and schools of thought::QDHC East Asian and Indian philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
    Keywords: chronic rhinosinusitis ; B-cell lymphoproliferative disorder ; sinus ; nasal allergies ; tannery worker ; Kanpur ; asthma ; ovalbumin ; saffron ; salbutamol ; IL’s ; TNF-α ; allergic rhinitis ; bronchial asthma ; allergy ; Th17 cells ; IL-17 ; IL-33 ; microRNA ; miR ; airway mucosal inflammation ; united airway disease ; acute rhinosinusitis ; acute recurrent rhinosinusitis ; Mediterranean diet ; nutritional evaluation ; nutritional therapy ; olfactory dysfunction ; anosmia ; post-acute COVID-19 ; nitric oxide ; NO ; exhaled NO ; FENO ; nasal peak flow ; atopic status ; total IgE ; specific IgE ; childhood asthma ; immunoblot ; ImmunoCAP ; otolaryngology ; sinusitis ; ethnic groups ; patient-reported outcome measures ; quality of life ; social justice ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
    Keywords: model-informed precision dosing (MIPD) ; efficacy PKPD indexes ; pharmacokinetics ; pharmacodynamics ; PKPD modeling and simulation ; dosing algorithms ; nomograms ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented.
    Keywords: ferulic acid ; total body irradiation ; bone marrow microenvironment ; stem cell senescence ; bone marrow injury ; reactive oxygen species ; antioxidant defense system ; planarians ; model animal ; irradiation ; regeneration ; radioprotection ; radiation ; melatonin ; nDNA-repair ; mtDNA-mutations ; oxidation stress ; protection ; mitigation ; H2O2 ; ATP ; MDA ; GSH ; X-ray radiation ; 3T3 fibroblasts ; proliferation ; apoptosis ; cellular stress ; senescence ; peroxiredoxin 6 ; Prdx6 ; radioprotector ; pharmacologic ascorbate ; vitamin C ; pancreatic cancer ; Auranofin ; thioredoxin ; thioredoxin reductase ; peroxiredoxin ; nuclear and radiological emergencies ; radioprotectors ; radiomitigators ; radionuclide scavengers ; radiation biodosimetry ; Olea europaea L. cv. Caiazzana ; oleacein ; ionising radiation ; cancer ; radiotherapy ; normal tissue ; radiosensitization ; radiomodulation ; proteomic analysis ; oxidative modification profiling ; serum albumin ; amino acid sequences ; radiation biomarker ; human lactoferrin ; acute gamma irradiation ; C57Bl/6 mice ; survival rate ; open field test ; spleen ; serum homeostasis ; leukocytes ; stilbenoid ; electron paramagnetic resonance (EPR) ; FT-IR ; electron beam radiation ; radioresistance ; oxidative phosphorylation ; oncometabolites ; radiation response ; bioinformatics ; oxidative stress ; transcriptomics ; radiobiology database ; gene signature ; ionizing radiation ; intestine ; mucositis ; microbiome ; microbiota ; dysbiosis ; bacterial dietary supplement ; radiomitigator ; hyperthermia ; combination therapy ; synergistic effect ; oxygenation ; hypoxia ; immune response ; Tameron ; antioxidant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases.
    Keywords: household air pollution ; fine particulate matter ; international environmental health ; cookstove ; respiratory disease ; brick worker ; particulate matter ; heavy metals ; Sulfate-Nitrate-Ammonium ; pollution levels ; mobile sources ; aerosols ; PAHs ; OC and EC ; transport sources ; urbanized coastal station ; grain dust ; health risk assessment ; Monte Carlo simulation ; disability adjusted life year ; multi-media exposure ; health risk ; probabilistic risk assessment ; Lake Chaohu ; PM10 ; health risks ; extreme learning machine ; echo state network ; neural networks ; pollution ; concentration ; indicators ; aberrant values ; nitrogen oxides ; ARIMA ; GRNN ; ARIMA–GRNN ; isolation forest ; LOF ; AOD ; classification ; dendrogram ; PCA ; air quality index ; polluting agents ; respiratory diseases ; monitoring stations ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: There has been a rapid development in the academic literature over the last ten years on papers relating to individualization, personalization, patient-, client-, consumer- and person-centredness, with work on conceptual, instrumental, observational, and experimental levels. This Special Issue presents papers that can further establish the current state of science on these topics relating to personalized nursing and health care. We collected papers that highlight and further the knowledge base conceptually, instrumentally, observationally, and experimentally with sound theoretical and methodological underpinnings and implications for research, theory, and clinical work in the disciplines of nursing, medicine, allied health, and beyond.
    Keywords: anxiety ; life satisfaction ; life–work concerns ; melatonin ; cortisol ; biopsychosocial model ; obstetric complications ; patients’ rights ; student ; nursing ; personalized medicine ; HIV ; mobile health ; smartphone application ; symptom management ; nurse practitioners ; nursing home ; COVID-19 ; palliative care ; end-of-life ; dignified death ; older adults ; accidental falls ; fall prevention ; barriers ; patient compliance ; music therapy ; dementia ; caregiver ; RCT ; patient-centred care ; competence ; assessment ; instrument ; measurement ; validity ; reliability ; individual care ; nurses ; older diabetes patients ; physicians ; support ; Parkinson’s disease ; nursing training ; integrated care ; Parkinson nurse ; personalized care ; multidisciplinary care ; patient-centered ; arthritis ; autoimmune disease ; sociopsychological factors ; emotion ; depression ; self-identity ; qualitative study ; observational study ; dysmenorrhea ; kinesio tape ; auricular acupressure ; pain ; nursing care ; patient care planning ; quality of health care ; conditional inference trees ; education ; distance ; learning ; digital ; drawings ; Nigeria ; perinatal loss ; social networks ; stillbirth ; stillborn ; functional status ; health care ; hospitalization ; activities of daily living ; pelvic floor muscle exercises ; pelvic floor dysfunction ; qualitative research ; therapeutic exercise ; therapeutic adherence ; women’s health physiotherapy ; diabetes mellitus type 2 ; prediction model ; LogicRegression ; interpretability ; pelvic organ prolapse ; lifestyle changes ; women’s experience ; n/a ; foot ; foot self-care ; methodological review ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Dry pasta is one of the most popular staple foods worldwide due to its convenience in terms of affordability, versatility, long shelf life, as well as sensory and nutritional value. As such, it represents a suitable carrier for health-promoting substances providing specific physiological functions. This Special Issue deals with the continuum aspects, “from seed to fork”, that could have an impact on the nutritional, sensory, and technological aspects of pasta. In this Special Issue, we aimed to publish innovative research and review papers on physico-chemical and sensorial characteristics, nutritional value, functional and technological properties of pasta, and pasta-making processes. New raw materials, new functional ingredients, up-cycling of waste materials, in vivo experiments to test the effect of assumption of the supplemented pasta, and innovative packaging systems will also be addressed in this Special Issue. Predictions of pasta quality adopting chemometrics as well as multi-variate and statistical data analysis approaches were welcomed. Finally, in the medium term, the international pasta market is expected to stay negative unless tangible product innovations are introduced, particularly regarding the technological innovations aimed at improving the products’ health benefits. This Special Issue aimed to provide a fundamental understanding and present the current strategies to improve the technological, nutritional, and sensory properties of pasta.
    Keywords: innovative pasta raw materials ; durum ; emmer ; spelt ; pasta ; brewers’ spent grain ; dietary fiber ; einkorn ; functional pasta ; tritordeum ; upcycling ; unconventional ingredients ; nutritional value ; cooking quality ; legumes ; Spirulina Platensis ; resistant starch ; hydrolysis index ; dietary fibre ; annealing ; slowly digestible starch ; carbohydrates ; fiber ; in vitro digestion ; micronization ; brown rice ; air fractionation ; parboiling ; rice pasta ; enriched pasta ; bioactive compound ; tuna ; sea bass ; Ω-3 fatty acids ; sensometrics ; TPA (texture profile analysis) ; glycemic index ; glycemic response ; durum wheat ; landraces ; starch ; available carbohydrates ; glycemic load ; texture profile analysis ; gluten-free ; celiac disease ; fish ; allergy ; pear, date, and apple by-products ; wheat flour ; sensorial properties ; scanning electron microscopy ; multiple factor analysis ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated.
    Keywords: RSV ; ectodomain G protein ; heparan sulfate ; protein–ligand interaction ; fluorescence quenching ; molecular docking ; molecular dynamic simulation ; quercetin ; CCL4 ; neurotoxicity ; VirtualToxLab ; oxidative stress markers ; Huperzine A ; molecular dynamics simulation ; fluorescence spectroscopy ; human serum albumin ; neurodegenerative disorders ; drug–protein interactions ; erlotinib ; bovine serum albumin ; binding interaction ; competition ; hepatitis E virus ; methyltransferase ; protein stability ; enzyme assay ; garlic ; antioxidant ; anti-glycation ; glycation ; AGEs ; HSA ; quetiapine ; hydrophobic interaction ; thermodynamic parameters ; seproxetine ; antidepressant ; charge transfer ; π-acceptors ; DFT ; haloperidol ; antipsychotics ; keratoconus ; MMP-2 ; MMP-9 ; molecular dynamics ; MM-GBSA calculations ; pharmacophore mapping ; α-amylase ; advanced glycation end-products ; caffeic acid ; coumaric acid ; coronary artery disease ; phytotherapy ; network pharmacology ; angiogenesis ; zebrafish ; dynamics molecular docking ; NEK7 ; virtual screening ; DFTs ; deep learning ; drug design ; drug repurposing ; structural-based ; cancer ; A. aspera ; β-amyrin ; C. gigantea ; C. procera ; GC-MS ; Minimum inhibitory concentration (MIC) ; Molecular docking ; MD simulations ; Tuberculosis (TB) ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Presses universitaires de Rennes
    Publication Date: 2024-03-23
    Description: Depuis deux cents ans, la littérature, la philosophie et le cinéma s’intéressent toujours davantage à l’apocalypse et aux catastrophes. Est-ce céder à un certain nihilisme ou au contraire chercher une ouverture politique quand l’horizon semble fermé ? Explorant la force et les limites de cet imaginaire politique ambivalent, les contributions rassemblées dans ce volume tentent d’expliquer pourquoi le scénario apocalyptique fait retour dans une civilisation qui n’est plus soudée ni par la croyance religieuse ni par l’espoir révolutionnaire. Qu’est-ce qui distingue l’apocalyptisme contemporain de l’apocalyptisme biblique et de ses avatars ? Comment distinguer un apocalyptisme laïc, qui affronte avec lucidité la perspective d’une destruction par l’homme des conditions nécessaires à la poursuite de son existence et les lubies des marchands d’apocalypse, qui mobilisent et galvaudent à leur profit le scénario religieux ? Enfin, comment restaurer une perspective politique dans ce climat de destruction générale ? En réunissant des contributions d’historiens, de philosophes, de spécialistes de littérature, d’études théâtrales et de cinéma, ce volume de La Licorne entreprend d’approcher de façon critique un art de désespérer avec espoir caractéristique de l’époque contemporaine.
    Keywords: littérature ; nihilisme ; cinéma ; théâtre ; thema EDItEUR::A The Arts ; thema EDItEUR::D Biography, Literature and Literary studies::D Biography, Literature and Literary studies::DS Literature: history and criticism ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This book presents a collection of papers revealing the impact of advanced computation and instrumentation on healthcare. It highlights the increasing global trend driving innovation for a new era of multifunctional technologies for personalized digital healthcare. Moreover, it highlights that contemporary research on healthcare is performed on a multidisciplinary basis comprising computational engineering, biomedicine, biomedical engineering, electronic engineering, and automation engineering, among other areas.
    Keywords: eHealth ; mHealth ; telemedicine ; telehealth ; social sciences ; bibliometrics ; telediagnostic ; project management ; funding ; IT infrastructure ; cross-border multiprofessional team ; European Union ; Interreg ; reporting ; quality control ; resident ; diagnostic error ; artificial intelligence ; healthcare AI ; deployment and scaling ; medical center ; critical factors ; stakeholders ; health information technology ; information sharing ; hospital costs ; poverty ratio ; concentration ; continuous glucose monitoring ; insulin pump ; continuous subcutaneous insulin infusion ; pediatric diabetes ; biomedical data ; medical imaging ; shared data ; massive databases ; AI-based healthcare solutions ; trueness ; 3D printing ; milling ; interim dental crown ; digital dentistry ; dental device ; data mining ; bio-signal analysis ; bio-signal repository ; execution engine ; bio-signal monitoring ; digital healthcare ; patient-centric ; blockchain ; federated learning ; coronavirus (COVID-19) ; pandemic management ; healthcare transformation ; public health strategies ; stroke detection ; portable head scanner ; low-intensity EM waves ; intrinsically safe ; low carbon footprint ; orthodontic treatment ; clear aligners ; smart application ; AI ; computerized learning ; behavior change techniques ; decision tree algorithm ; digital interventions ; mental health literacy ; audiovisual ; dentistry ; computer-controlled local anesthetic delivery ; ultrasounds ; chemomechanical caries removal ; modern technologies ; laser ; ozone ; healthcare ; emergency department ; patient flow ; simulation modeling ; agent-based modeling ; pandemic decision support ; additive manufacturing ; patient-centric dosage form ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: As we know, strokes are one of the world's leading causes of death, and the cruel aspect of a stroke is that it leaves people with severe functional disability and/or cognitive impairment. Strokes have a significant impact on economies worldwide, as it is estimated that about 10% of the male population and 8% of the female population are affected by them. Such people need personal help in their everyday life and must be materially supported by social services. With the advancement of medicine, artificial intelligence, and new technologies have been developing rapidly and are gradually applied in diseases of the nervous system, increasingly helping diagnosis, treatment, rehabilitation, and prognosis of disease.This Special Issue has collected the 14 papers on artificial intelligence and new technologies in strokes, including in the aspects of diagnosis, treatment, prognosis, rehabilitation, and nursing. We welcome your reading.
    Keywords: non-invasive brain stimulation ; stroke ; spasticity ; meta-analysis ; hemiplegia ; electromyographic bridge ; upper limb rehabilitation ; randomized controlled trial ; hypoxic ischemic encephalopathy ; disorders of consciousness ; metabolic connectivity ; positron emission tomography ; 18F-fluorodeoxyglucose ; hand function rehabilitation ; hand rehabilitation robot ; computer vision technology ; wearable devices ; sensors ; artificial intelligence ; brain–computer interface ; active rehabilitation training ; motor function ; brain function ; executive function ; postural control ; gait ; repetitive transcranial stimulation ; facial paralysis ; peripheral magnetic stimulation ; blood flows ; laser speckle ; stroke rehabilitation ; upper limb ; automated system ; motor function assessment ; Fugl-Meyer Assessment ; motor attempt (MA) ; EEG ; deep learning method ; overlapping time window ; facial expression recognition (FER) ; vision transformer (ViT) ; convolutional neural networks (CNNs) ; rehabilitation ; assessment ; upper extremity ; hand ; brain–computer interfaces ; motor task ; sensorimotor rhythm ; hand rehabilitation ; motor imagery ; virtual reality ; rTMS ; DTI ; immersive virtual reality ; post-stroke cognitive impairment ; aging ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Hyperbaric oxygen is a known therapeutic agent, and treatments using this agent remain a matter of discussion and research. This Special Issue collection will add new knowledge and also offer some not so usual approaches to foster contemporary understanding and potential benefit for patients and scholars.
    Keywords: hyperbaric oxygen therapy (HBOT) ; Hyperoxia ; wound healing ; antimicrobial properties ; Coronavirus Disease-19 (COVID-19) ; critical flicker fusion frequency ; threshold of flicker fusion ; neuropsychology ; diving and hyperbaric medicine ; minimal hepatic encephalopathy ; diabetes ; hyperbaric oxygen therapy ; glycaemia ; oxygen ; hyperbaric oxygen ; epigenetics ; normobaric oxygen paradox ; hyperoxic-hypoxic paradox ; frostbite ; classification ; cold disease ; prognosis ; amputation ; medical outcome ; atmosphere exposure chambers ; diving physiology ; decompression ; periodontal disease ; oral health index ; dental mobility ; periodontal pockets depth ; subfoveal choroidal thickness ; intraocular pressure ; central corneal thickness ; central serous chorioretinopathy ; flow-mediated dilation ; arterial stiffness ; endothelial dysfunction ; n/a ; FMD ; underwater ; hyperbaric ; commercial diver ; off-shore energy operation ; human ; adverse effects ; autonomic nervous system ; lung ultrasound ; mixed gas diving ; pulmonary function ; technical diving ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration.
    Keywords: bone ; collagen type I ; alginate ; conditioned medium ; viability ; MSC ; osteogenesis ; pulsed electromagnetic field ; osteogenic factors ; wool keratin scaffolds ; bone tissue engineering ; biocompatibility ; biomaterials ; bone augmentation ; bone conduction ; bone grafting ; calcium hydroxyapatite ; tissue regeneration ; dental implants ; osseointegration ; osteoporosis ; zoledronate ; animal model ; titanium membrane ; titanium foil ; occlusive titanium barrier ; guided bone regeneration ; osteoporotic condition ; xenograft ; bone regeneration ; titanium implants ; additive manufacturing ; reused powder ; unit cell topology ; tissue engineering ; mechanical properties ; stem cells ; surface functionalization ; titanium ; protein adsorption ; surface modifications ; cell interactions ; collagen hydrogel ; cell delivery ; olfactory ectomesenchyme stem cells ; bioactive glasses ; alkali-free ; sol–gel ; bone remodeling ; bone disorders ; biomechanics ; scaffolds ; microenvironment ; 3D bioprinting ; computational modeling ; bone implant ; bone defects ; chitosan ; degree of deacetylation ; bone formation ; X-ray micro CT ; histology ; sheep tibia ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This reprint focuses on the current progress in sports medicine, with a specific interest in surgery, exercise therapy, and multi-disciplinary research. With the advancement of society, more attention is paid to the quality of life, which emphasizes the importance of sports and exercise. Correspondingly, there is a great need for sports medicine. This issue collected novel findings on sports medicine in surgery, conservative therapy, and the application of exercise training in other disorders
    Keywords: shoulder ; rotator cuff ; allografts ; demineralized bone matrix ; biologics ; diabetes mellitus ; aerobic training ; resistance training ; vascular function ; meta-analysis ; femoroacetabular impingement ; hip arthroscopy ; longitudinal capsulotomy ; femoroplasty ; labrum repair ; degenerative lumbar diseases ; albumin-to-alkaline phosphatase ratio ; spinal fusion rate ; prognostic marker ; arterial hypertension ; exercise hypertension ; blood pressure ; exercise testing ; sports injuries ; machine learning ; injury prediction ; sports monitorization ; elite football ; performance ; systemic inflammation ; physical endurance ; physical fitness ; maximal aerobic capacity ; gingivitis ; cardiac rehabilitation ; exercise therapy ; balance exercises ; cardiovascular diseases ; ACLR ; hamstring tendon with preserved tibial insertion ; MRI ; T2 ; cartilage volume ; gait retraining ; running-related injuries ; kinetics ; kinematics ; rehabilitation ; rotator cuff tear ; rotator cuff repair ; bone quality ; osteopenia ; osteoporosis ; anchor pullout ; pullout strength ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Novel Anticancer Strategies (Volume II) reviews important findings and updates within the cancer therapy field of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key Features:Nanoparticle-based drug delivery in cancer therapy;Nanoerythrosomes;Cancer immunotherapy;Therapeutic vaccines;Oncogenic and tumor suppressive components of the cell cycle;Antimitotics in cancer clinical trials;Multifunctional enzymes as anti-cancer drug targets;Targeting undruggable proteins and non-coding RNAs;Cell-penetrating peptides;Repurposed cancer drugs in clinical trials;Circulating tumour cells.
    Keywords: Breast cancer treatment ; Photodynamic therapy ; Inorganic nanoparticles ; Active targeting ; cathepsins ; BAX ; MOMP ; ubiquitination ; apoptosis ; chemotherapy ; cancer ; nanoerythrosome ; nanoerythrocyte ; nanovesicles ; biomimetic ; cancer therapy ; diagnostics ; imaging agents ; cell cycle ; cyclin-dependent kinase ; p16 ; p21 ; p27 ; breast cancer ; prognosis ; drug delivery ; HL60 ; leukemia ; prodrug ; resistance ; retinoic acid ; vitamin K ; drug repurposing ; COVID-19 ; pandemic ; vaccination ; multi-drug resistance ; enhanced permeation and retention effect ; nanotherapeutics ; cancer theranostic ; clinical translation ; cell-penetrating peptides ; protein transduction domains ; tumor imaging ; targeted therapies ; dog ; comparative oncology ; molecular targets ; spheroids ; tumoroids ; hydrogel ; collagen ; agarose ; mammary spheroids ; tissue engineering ; cisplatin ; melanoma ; melanin nanoparticles ; cytotoxicity ; laser medical applications ; hyperthermia ; antimitotics ; mitotic slippage ; spindle assembly checkpoint ; clinical trials ; TRAIL ; cancer stem cells ; TRAIL resistance ; angiogenesis ; on-demand drug delivery systems ; electrospun nanofibers ; poly (N-isopropylacrylamide) ; gold nanorods ; paclitaxel ; β-Cyclodextrin ; SPIONs ; metallodrugs ; RAPTA derivatives ; phosphino-amine ligands ; CTCs ; NSCLCs ; metastasis suppression ; curcumin ; flavonoids ; TNBC ; immunotherapy ; immune checkpoint ; nanocarrier ; combinational immunotherapy ; lung cancer ; miRNA ; oncomiRs ; photodynamic therapy PDT ; porphyrin ; iron oxide nanoparticles ; mesoporous silica nanoparticles ; antibody functionalization ; targeted drug delivery systems ; molecular-targeted therapies ; multifunctional enzymes ; HCC ; CHRNA5 ; metastasis ; stemness property ; sorafenib sensitivity ; neoantigens ; vaccine ; Patched ; chemotherapy resistance ; metastases ; persistent cells ; adrenocortical carcinoma ; BUB3 ; mitosis ; senescence ; anticancer target ; boron neutron capture therapy ; 4-borono-l-phenylalanine ; drug discovery ; solubility ; mebendazole ; polymer ; HPMA ; controlled drug release ; PLK1 ; BI2536 ; Navitoclax ; slippage ; PD-1 ; gemcitabine ; new anti-cancer drugs ; precision medicine ; undruggable targets ; non-coding RNAs ; oligonucleotide therapeutics ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Almost all fields of dentistry are closely related to newly developed materials, and all clinical improvements often follow, or, in any case, go hand in hand with the creation and the development of innovative and higher performing materials, instruments, and equipment. Thanks to contemporary applications of dental materials, the effectiveness of clinical dentistry has made remarkable advances. In recent years, thanks to digital technology and the frenetic development of the dental industry, new materials have been developed and proposed in many fields of dentistry: prosthesis, restorative dentistry, endodontics, implantology, and orthodontics. Unfortunately, as often happens, this productive challenge is not always accompanied by valid scientific research, and consequently the clinician finds new materials at their disposal that are not necessarily better than the old. Further studies are needed to gain relevant evidence for all recently introduced dental materials. This reprint includes research articles, clinical studies, review articles, and case reports focused on the latest advances and prospects of dental materials concerning all fields of dentistry.
    Keywords: MIH ; hypersensitivity ; enamel infiltration ; hypomineralization ; marginal adaptation ; fixed partial denture ; dental technology ; cobalt–chromium alloys ; scanning electron microscopy ; titanium ; dental implants ; hydrophilic ; hydrocarbon ; biological ageing ; UV photofunctionalization ; alveolar bone defects ; guided bone regeneration ; titanium meshes ; customized titanium meshes ; laser melting process ; electron beam melting ; composite restoration ; microleakage ; oblique layering technique ; horizontal layering technique ; composite ; fluorescence ; de-bonding ; residuals ; enamel damage ; orthodontics ; radiolucent sign ; OPG ; CBCT ; third molar ; oral surgery ; periapical sign ; biofilm ; bone healing capacity ; infected gutta-percha ; rat calvarium ; zirconia ; airborne particle abrasion ; femtosecond laser ; flexural strength ; surface roughness ; bond strength ; brackets ; dry ; wet and moistened enamel ; adhesion ; calcium phosphate ; radiation-induced center ; hyperfine interaction ; EDNMR ; ESEEM ; ENDOR ; biomaterial ; bone regeneration ; bone substitute ; dental implant ; octacalcium phosphate ; TiN ion plating ; metal allergy ; orthodontic wire ; micro-implants ; success rate ; insertion ; loading ; biocompatibility ; compliance ; dental material ; restorative material ; glass ionomer ; resin-modified glass ionomer ; pH ; acidity ; oral environment ; dental filling ; dental restoration ; apical negative pressure irrigation ; calcium hydroxide removal ; intracanal medicament ; mechanical activation ; ultrasonic activation ; osseoincorporation ; osseointegration ; trabecular metal ; guided tissue regeneration ; barrier membranes ; allergology ; demineralized dentin matrix ; human demineralized dentin matrix ; human ; bone graft ; FT-MIR ; SEM ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Childhood cancer or pediatric cancer is one of the leading causes of death among children. Treatment strategies for pediatric cancers include chemotherapy, surgery, radiation, and stem cell transplantation. These therapeutic regimens are well known to develop highly toxic and long-lasting side-effects including secondary cancers in the future lifespan of pediatric patients. Despite these intensive therapeutic regimens, cancer may still relapse as refractory and metastatic cancer. Therefore, further understanding the causes of different pediatric cancers, mechanisms of drug-resistance, and causes of relapse and metastasis is required for developing and advancing less toxic and more effective therapeutic strategies for pediatric cancers. Recent advancements in immunotherapies and targeted therapeutic approaches using pharmacological inhibitors are one step in this direction.In this Special Issue of Cancers, authors contributed original research and review articles focusing on different aspects of pediatric cancer development, causes, maintenance, and therapeutic strategies. The collected articles in this Special Issue will further enhance our knowledge and understanding of pediatric cancers and drive the development of novel therapeutic strategies.
    Keywords: infections ; cancer ; children ; bacteremia ; pneumonia ; sarcoma ; solid tumor ; outcome ; KI67 ; EZRIN ; 18F-FDG PET/CT ; random forest ; radiogenomics ; chemotherapy response ; metastasis ; serine-threonine kinase receptor-associated protein ; neuroblastoma ; CRISPR-Cas9 ; metronomic chemotherapy ; maintenance therapy ; high-risk ; Ewing sarcoma ; RNA-binding proteins ; regulation network ; prognosis prediction ; risk model ; melanotic neuroectodermal tumor of infancy ; inoperable ; metastatic ; recurrent ; chemotherapy ; adjuvant ; neoadjuvant ; systemic treatment ; childhood malignant bone tumors ; survivorship ; late effects ; somatic disease ; cohort study ; rhabdomyosarcoma ; targeted therapies ; cell surface proteomics ; B7-H3 ; stress ; allostasis ; stress regulatory pathways ; stress dysregulation ; stress reactivity ; early life stress ; childhood cancer ; cytotoxic cancer treatment ; interventions ; ependymoma ; risk stratification ; molecular group ; prognosis ; nephroblastoma ; clinical malformations ; cancer predisposition syndromes ; tumor surveillance ; n/a ; DSRCT ; EWSR1-WT1 ; preclinical model ; in vitro model ; pediatric cancer ; pediatric ; brain ; tumor ; medulloblastoma ; glioma ; natural products ; drug discovery ; fungal secondary metabolites ; soil microbes ; RH30 ; RD ; EZH2 ; epigenetic ; EPZ005687 ; DZNep ; AdOx ; malignant rhabdoid tumor ; hepatoblastoma ; small cell undifferentiated (SCUD) hepatoblastoma ; SMARCB1 ; INI1 ; pediatric liver tumors ; drug repurposing ; PI3K pathway ; epigenetics ; Fimepinostat ; LPAR1 ; LPA ; tumor metastasis ; bioinformatics analysis ; ulixertinib ; ERK inhibition ; combination therapy ; c-Myc/N-Myc ; cell differentiation ; ATRA ; SOX4 ; diffuse intrinsic pontine glioma ; immunotherapy ; immune microenvironment ; immune checkpoint inhibitor ; vaccine ; oncolytic virus ; myeloid sarcoma ; chloroma ; acute myeloid leukemia ; pediatric cancers ; VIPN ; DIC ; MDR ; drug transporters ; childhood acute leukemia ; early complication ; hyperleukocytosis ; risk factor ; survival outcome ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The researchers involved in this reprint will continue their studies to improve the existent dental biomaterials in order to achieve optimal dental treatment with biocompatible, bioactive, and stable properties. As the Guest Editors, we sincerely value and thank the reviewers for their insightful comments and the support of the team at Bioengineering. Finally, we express our gratitude to all contributing authors for their valuable research. Altogether, the 16 research papers/reviews in this Special Issue entitled "Recent Advances in Biomaterials and Dental Disease" reflect the importance of in vitro and in vivo studies for improving the efficacy of using biomaterials in dental treatment.
    Keywords: adhesion ; bonding ; dental porcelain ; glass ceramics ; orthodontic bracket ; shear strength ; aligner ; cytotoxicity ; estrogenicity ; invisalign ; monomer ; retainer ; 3D resin ; endodontic sealer ; polyphenols ; resveratrol ; pyrogallol ; biological activity ; piezoelectric surgery ; endodonticsurgery ; crack formation ; ultrasonic tip ; retropreparation ; antibacterial effect ; dental impressions ; disinfectant agents ; disinfection ; oral bacteria ; implant periapical lesion ; implant failure ; peri-implantitis ; endodontic surgery ; complication ; retreatment procedure ; filling materials removal ; revision system ; sonic activation ; oval-shaped canal ; decontamination ; lithium disilicate ; resin ; saliva ; shear bond strength ; crowns ; fixed prosthodontics ; resin composite ; survival ; bond strength ; contact angle ; dentin ; desensitizers ; resin cements ; 3D printing ; digital light processing ; interim crown ; in vivo study ; wear ; endodontists ; general practicing dentists ; root canal treatment ; quality ; undergraduate students ; traumatic dental injury ; tooth fracture ; adhesive reattachment ; pulp ; regeneration ; revitalization ; transplant ; root ; maxillary premolars ; upper premolars ; canal ; root canal anomalies ; anatomical variations ; root morphology ; coneless ; MEA technique ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: This reprint focuses on recent advances in the clinical care of patients with acute and chronic coronary syndromes. We must accumulate novel scientific and clinical knowledge in this field to develop seamless treatments and preventive strategies for this patient population. Furthermore, accumulated data have implicated that there are some residual risk factors for coronary syndromes, and the clinical management of cardiovascular/non-cardiovascular complications associated with coronary syndromes is also a critical concern. We hope that this reprint will facilitate the management of future patients with coronary syndromes; however, further research is still required. It is also our hope that this reprint will promote future research to enable a better understanding of the clinical practice of coronary syndromes.
    Keywords: statin ; myocardial infarction ; renal function ; coronary CT angiography ; subtraction ; fractional flow reserve ; coronary artery disease ; Agatston score ; uric acid ; endothelial function ; ischemic heart disease ; ischemia with no obstructive coronary artery disease ; angioplasty ; drug-eluting stents ; non-ST-elevation myocardial infarction ; multivessel disease ; acute coronary syndrome ; chronic coronary syndrome ; xanthine oxidoreductase ; coronary artery spasm ; gender differences ; vasospastic angina ; microvascular spasm ; microvascular vasodilatory function ; high coronary thrombus burden ; tissue plasminogen activator ; catheter-directed thrombolysis ; olmesartan ; amlodipine ; rosuvastatin ; single pill combination ; phase III clinical trial ; computed tomography ; computed tomography perfusion ; myocardial perfusion abnormality ; aspirin ; clopidogrel ; prasugrel ; P2Y12 inhibitor ; bleeding ; nitrate ; vasodilator ; biomarker ; mortality ; risk-score model ; n/a ; NGAL ; contrast-induced acute kidney injury ; percutaneous coronary intervention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
    Language: English
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  • 84
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This book contains research articles on the advances in the aetiology of idiopathic scoliosis (IS), the spinal growth related to the implementation of growth modulation for the surgical treatment of early-onset IS, the non-surgical treatment of IS using Physiotheraputic Scoliosis Specific Exercises, and braces. Additionally, it focuses on issues related to surgical treatment, issues related to body posture and the quality of life of this sensitive group of people. The high quality of published papers in this Special Issue of the JCM serve these objectives.
    Keywords: idiopathic scoliosis ; health-related quality of life ; cultural adaptation ; Italian Spine Youth Quality of Life Questionnaire ; systematic review ; meta-analysis ; adolescent idiopathic scoliosis ; brace therapy ; brace concepts ; rigid brace ; night time brace ; ring apophysis ; maturation ; ossification ; fusion ; scoliosis ; nighttime orthotic treatment ; surgery ; quality of life ; paraspinal muscles ; cross-sectional area ; posterior approach ; computed tomography ; Italian spine youth quality of life questionnaire ; SRS-22 ; 22q11.2 deletion syndrome ; human model ; neuromuscular scoliosis ; radiography ; MRI ; curve morphology ; intraspinal anomaly ; body height ; pulmonary function test ; Cobb angle ; iTRAQ ; α-actin ; progressive ; differentially expressed proteins ; bracing ; physiotherapeutic scoliosis-specific exercise ; physical activity ; adherence ; spinal appearance ; shared decision-making ; personalised approach ; sclerostin ; osteocytes ; β-catenin ; Wnt signaling pathway ; scoliometer ; truncal asymmetry ; lateral spinal profile ; surface topography ; aetiology ; spinal deformities ; pathobiomechanics ; follow-up study ; Rett syndrome ; motor skills ; telerehabilitation ; physical therapy modalities ; home exercise program ; neurodynamic functions ; assessment ; pain ; treatment ; early onset scoliosis ; non-operative treatment ; body posture ; sports activity ; corrective exercises ; digital photography ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 85
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Advancements in medical imaging modalities have resulted in increasing the importance and demand of pediatric radiology. This reprint showcases various examples of advanced research in pediatric radiology and nuclear medicine. These include the use of medical imaging modalities such as computed tomography, general radiography, magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and ultrasound for diagnosis, as well as the performance of artificial intelligence (AI) in computer-aided detection and diagnosis in the pediatric population. The radiation dose issue of pediatric radiological examinations and emerging AI technology for dose reduction, as well as the use of three-dimensional printing based on medical images for pediatric surgical planning, healthcare professional education, and patient–clinician communication are also covered.
    Keywords: as low as reasonably achievable ; computed tomography ; convolutional neural network ; deep learning ; dose reduction ; generative adversarial network ; image processing ; machine learning ; medical imaging ; noise ; contrast-enhanced ultrasound ; head ultrasound ; brain death ; infants ; ancillary test ; child ; paediatric ; infant ; adolescent ; chest X-ray ; CXR ; chest radiography ; COVID-19 ; SARS-CoV-2 ; coronavirus ; biliary atresia ; ultrasonography ; diagnostic accuracy ; intraoperative cholangiography (IOC) ; diagnostic performance ; elastography ; three-dimensional printing ; congenital heart disease ; children ; model ; personalized medicine ; application ; confusion matrix ; disease identification ; image interpretation ; pneumonia ; artificial intelligence (AI) ; deep learning (DL) ; paediatric pneumonia ; chest radiograph ; computer-aided detection (CAD) ; cumulative ; radiation dose ; acute tonsillitis ; shear wave elastography ; stiffness ; pediatric ; magnetic resonance imaging ; infection ; neck ; emergency medicine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: A full awareness of the role played by a healthy diet, as part of a healthy lifestyle, in countering or slowing-down chronic and degenerative diseases has strongly increased the interest in food bioactives and the return of ancient foods that are nowadays considered functional. In fact, these dietary substances, to which nutraceutical attributes are increasingly entrusted, could display disease-preventing effects on animals and humans. In this context, polyphenols, which are widespread and mostly copious in dietary plant sources, have gained a lot of attention thanks to their potential ability to halt or reverse oxidative stress-related diseases. Indeed, food could contain, beyond health-promoting compounds, toxicants which are naturally occurring or process-induced dietary compounds with adverse effects on human health. The presence and abundance of bioactives are strictly related to their food source. Edible plant components largely contain beneficial secondary metabolites, but understanding them fully is still an important challenge as complex biotic and abiotic interactions are involved in their biosynthesis. Analytical methods, which are increasingly powerful, could enhance our knowledge of food bioactives, whereas the deep investigation of their bioactivity and bioavailability could make them particularly useful.
    Keywords: Urtica dioica ; natural products bioactivity ; food bioactives ; nutraceuticals ; cancer therapy ; breast cancer ; Aloe vera ; Aloe vera polysaccharides ; in vitro fermentation ; SCFAs ; antioxidant capacity ; food waste recovery ; grape leaves ; UHPLC-HR-MS/MS analysis ; flavonol glycuronides recovery ; linoleic acid peroxidation products ; hexane ; gastric cells ; metabolomics ; cDNA microarray ; avocado ; LC/MS ; fat-soluble vitamins ; carotenoids ; Cannabis sativa L. ; phenylamides ; lignanamides ; hemp seeds ; high resolution tandem mass spectrometry ; U-87 glioblastoma cells ; cytotoxicity ; Pistacia vera ; antioxidant ; quality ; tocopherol ; FTIR ; discriminant analysis ; pistacia (Pistacia vera) hulls ; anticancer ; bacterial resistance ; efflux pumps ; terpenoids ; thymol ; carvacrol ; Rosmarinus officinalis L. ; fresh young shoots tincture ; polyphenols ; terpenes ; hepatoprotective ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 87
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Gastrointestinal (GI) malignancies represent a diverse spectrum of cancers with notable global incidence and prevalence. The comprehensive care of individuals affected by these malignancies is a multifaceted endeavor involving the collaboration of various medical disciplines. The nonspecific clinical manifestations of GI cancers often present a formidable diagnostic challenge to primary care providers, resulting in diagnostic delays. Subsequently, the treatment regimens, once initiated, are often demanding and prolonged, and profoundly impact the patients' overall quality of life. Given the intricate involvement of the digestive system, nutritional concerns are pervasive among these patients, influencing both their quality of life and survival. Despite these considerable challenges, the evolving landscape of treatment modalities has yielded improved outcomes, enabling a greater number of patients to achieve remission or extended survival. It is now imperative that we delve deeper into understanding the unique needs of this patient population and refine the care delivery pathways through enhanced diagnostic approaches, treatment strategies, and holistic support, and ultimately enhance the overall value of care provided to individuals afflicted by GI malignancies.
    Keywords: HCV ; esophageal cancer ; male ; interferon ; mortality ; colorectal cancer ; gynecologic cancer ; retrospective cohort study ; colonoscopy screening ; gastric cancer ; ascites ; postoperative follow-up ; gastrectomy ; endoscopic submucosal dissection ; early gastric cancer ; type 2 diabetes mellitus ; glycemic control ; insulin resistance ; hepatocellular carcinoma ; annexin A2 ; prognostic marker ; survival outcome ; biliary tract cancer ; circulating tumor cell ; vimentin ; diagnosis ; prognosis ; gastric xanthelasma ; synchronous/metachronous gastric cancer ; genetic alteration ; predicting marker ; interval cancer ; screening ; endoscopy ; national cancer screening program ; c-Myc ; genetic linkage analysis ; cigarette smoking ; survival ; CRC ; CCL2 ; CCL4 ; CCL15 ; diagnostic utility ; gastrointestinal malignancies ; cancer survivorship ; calcium carbonate ; hypercalcemia ; cancer outcomes ; bic Book Industry Communication::M Medicine
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  • 88
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries.
    Keywords: infliximab ; etanercept ; TNFα inhibitors ; biologics ; biosimilars ; Germany ; policies ; incentives ; uptake ; market dynamics ; biosimilar market ; biosimilar/supply and distribution ; biosimilar sustainability ; Delphi technique ; pricing ; reimbursement ; utilization ; biosimilar ; biological ; information ; education ; communication ; patient ; Europe ; adalimumab ; biosimilarity assessment ; quality attributes (QAs) ; potentially critical quality attributes (pCQAs) ; European public assessment reports (EPARs) ; clinical governance ; Spain ; barriers ; regulatory ; review ; approval ; clinical ; queries ; regulatory science ; budget impact analysis ; savings ; pharmaceutical spending ; cost containment ; reference biological ; competitive market ; Belgium ; trastuzumab ; intravenous ; subcutaneous ; HER2-positive breast cancer ; drug costs ; healthcare costs ; cost simulation ; tender ; procurement ; off-patent ; award criteria ; switching ; interchangeability ; sustainability ; competition ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
    Language: English
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  • 89
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Researchers have made great progress in the mechanism of mycotoxins biosynthesis, pathogenicity, and the construction of detection methods. This collection holds fundamental and applied research on pathogenic fungi and mycotoxins in China, which directly or indirectly affect the health of plants, animals, and humans. Some papers mainly study the mechanism of mycotoxin biosynthesis, including the crucial genes, environmental factors, and regulation mechanisms, which is beneficial to advancing our knowledge of this area. Some papers focus on the toxicity of mycotoxins, which is helpful to the detoxification of mycotoxins and the reduction of the hazardous effect of mycotoxins. Special attention is given to the leading detection methods, especially on-site rapid detection. These effective and feasible methods are important for discovering and controlling the risk of mycotoxins.
    Keywords: water activity ; aflatoxin biosynthesis ; conidia development ; regulatory mechanism ; AtfB ; fumonisin B1 ; BALB/c mice ; fecal bacterial flora ; 16S rRNA sequencing ; zearalenone ; gilts ; ovary ; hormone ; weaned gilt ; intestinal morphology ; ghrelin ; PCNA ; farmers’ grain storage silos ; absolute water potential ; ventilation and drying ; mycotoxins ; contamination distribution ; Alternaria toxins ; modified QuEChERS method ; ultra-high-performance liquid chromatography-tandem mass spectrometry ; mixed fruit puree ; Aspergillus flavus ; AflN ; aflatoxin ; conidiation ; rice false smut ; ustiloxins ; generic antigen ; immuno-magnetic beads ; enzyme-linked immunity ; hepatotoxicity ; nephrotoxicity ; haematological toxicity ; regulatory limit ; αB-conotoxin VxXXIVA ; epitope ; hybridoma ; monoclonal antibody ; ELISA ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 90
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: This Special Issue delves deeply into the intricate distinctions between acute and chronic pain. Crucially, chronic pain is more than a mere by-product of sensory input; it entails the activation of a complex brain network intertwined with biopsychosocial factors. As such, its management emerges as a formidable clinical challenge. Within the scope of this Special Issue, focused attention is given to postoperative pain (POP) and chronic postsurgical pain (CPSP). POP, characterized by its predictability, intensity, and short duration, contrasts starkly with the potentially persistent and troublesome nature of CPSP, which can endure for over three months if not adequately addressed. The prevention of CPSP takes on paramount importance, with regional anesthesia techniques emerging as promising tools for intervention. The pivotal role of multimodal analgesia and combined therapeutic strategies is underscored. The Special Issue also delves into the intriguing realm of gender differences in pain perception, advocating for further research to illuminate these disparities. Risk factors contributing to the development of chronic pain following surgery are meticulously identified. Lastly, this Special Issue explores the potential of new technologies in the field of telemedicine and artificial intelligence to optimize care delivery, opening new avenues for enhanced patient outcomes and treatment strategies.
    Keywords: Postoperative pain ; Chronic postoperative pain ; Pain mechanisms ; Postoperative pain management ; Physiopathology of chronic postoperative pain ; Opioids ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 91
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The development of in vivo neuroimaging techniques has yielded an incredible amount of digital information about the brain. Neuroimaging techniques are increasingly being used to study human cognitive processes, create brain–machine interfaces, and also to identify and diagnose certain brain disorders. Currently, neuroscientists and medics actively use different methods for brain scans, including electro- and magnetoencephalography (EEG/MEG), functional near-infrared spectroscopy (fNIRS), electrocorticography (ECoG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and diffusion tensor imaging (DTI). Recent advances in signal processing and machine learning for neuroimaging data using various signal processing methods have made impressive progress in solving a number of practical tasks in medicine, healthcare, neuroscience, biomedical engineering, brain–machine interfaces, and cognitive science, to name but a few. This Special Issue aims to provide a forum for academic and industrial communities to present and discuss the latest theoretical and experimental results related to recent advances in neuroimaging data processing in terms of new theories, algorithms, architectures, and applications.
    Keywords: MEG ; FieldTrip ; Brainstorm ; source reconstruction ; flickering ; cognitive neuroscience ; visual perception ; detrended fluctuation analysis ; long-range correlations ; electroencephalogram ; sleep deprivation ; nonstationarity ; transfer entropy ; kernel methods ; Renyi’s entropy ; connectivity analysis ; phase interactions ; brain data ; low-cost devices ; EEG ; BIDS ; neuroscience ; library ; ambiguous stimuli ; Necker cubes ; classification task ; EEG analysis ; wavelet analysis ; decision time ; perceptual errors ; time-on-task effect ; brain connectivity ; artificial neural networks ; granger causality ; time series ; brain–computer interface ; event-related potential ; beamforming ; regularization ; BCI ; graphical user interface ; wheelchair navigation ; grid map ; natural landmark ; optimal paths ; deep Q-networks ; focal epilepsy ; diffusion imaging ; electroencephalography ; structure-function coupling ; seizure onset ; structural connectivity ; functional connectivity ; cognitive load ; coupling ; bubble entropy ; transition network ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 92
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Non-destructive testing and evaluation are commonly referred to as the vast group of analysis techniques used in civil, medical, and industrial sectors to evaluate the properties of materials, tissues, components, or structures, without causing any damage. Automation offers many benefits for non-destructive testing to cope with increasing demands, including improved reliability and higher inspection speeds. Additionally, robots enable inspections in locations that are not easily accessible to human operators and allow for humans to be removed from potentially dangerous environments. However, the perceived complexity and high costs have limited the adoption of automation. As a result, the full potential that could be derived from the seamless integration of robotic platforms with sensors, actuators, and software has not been fully explored; it could still revolutionise the way that automated inspections are performed and conceived. The recent advancements in electronics, robotics, sensor technology and software pave the way for new developments in automated testing and data-driven autonomous robotic inspections in several sectors. This Special Issue aimed to attract the latest research outcomes in the field of robotic sensing. Five papers relate to inspection systems based on robotic fixed-base manipulators, three of which are associated with in-process inspection in manufacturing applications (robotic wire-arc welding and additive manufacturing). Four papers report research advancements in mobile robotic-enabled sensing.
    Keywords: wall-climbing robot ; passive adaptive mechanism ; magnetic circuit optimization ; flexible detection method ; welding robot ; seam tracking ; laser sensor ; feature point extracting ; complex welding seam ; UAVs ; inspection ; soft robotics ; non-destructive evaluation ; robotic NDE ; robotic welding ; robotic control ; in-process NDE ; ultrasonic NDE ; ultrasound ; image motion analysis ; image processing ; optical flow ; underwater robotic ; NDT ; free-form surface profiling ; autonomous robotic systems ; in-process robotic NDE ; Wire + Arc Additive Manufacture (WAAM) ; ultrasound testing ; total focusing method ; defect recognition ; aircraft inspection ; deep learning ; CNN ; UAV ; defect classification ; AI ; underwater vehicle–manipulator system ; robotics emulator ; contact management ; remote inspection ; force control ; automated eddy current testing ; eddy current arrays ; robotics ; thermography ; non-destructive testing ; image alignment ; image blending ; n/a ; bic Book Industry Communication::M Medicine
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: The year 2021 marks the 10th anniversary of Journal of Clinical Medicine, and as one of the major sections of JCM, we are launching a 10th anniversary Special Issue in the section “Gastroenterology & Hepatopancreatobiliary Medicine”. We accepted papers for the Special Issue, titled "Recent diagnostic and therapeutic advance in Gastroenterology & Hepatopancreatobiliary Medicine". This medical field is a complex and wide-ranging field that deals with diseases in multiple organs such as the gastrointestinal tract and hepatobiliary pancreas. With recent advances in diagnostic imaging and interventional treatment, those in endoscopic diagnosis and treatment, those in functional test and those in genetic diagnosis and drug therapy, including the molecular-targeted therapy, many new medical findings have been accumulated. In this Special Issue, we looked for reports that make full use of advances in diagnostics and therapeutics in the field of Gastroenterology and Hepatopancreatobiliary Medicine.
    Keywords: TXI ; sessile serrated lesion ; hyperplastic polyp ; colonoscopy ; endoscopic submucosal dissection ; colorectal tumor ; traction method ; carbon dioxide ; CO2 insufflation ; abdominal pain ; abdominal distention ; transnasal endoscopy ; health check ; tranexamic acid ; gastrointestinal bleeding ; mortality ; thromboembolic events ; liver metastases ; colorectal liver metastases ; non-colorectal and non-neuroendocrine liver metastases ; liver resection ; Crohn’s disease ; biologics ; small-molecule drugs ; health-related quality of life (HRQoL) ; gastric cancer ; gastric cancer screening ; endoscopy ; H. pylori ; eradication therapy ; n/a ; functional bowel disorders ; gut microbiota ; personalized diet ; machine learning ; personalized medicine ; Turkey ; machine perfusion ; normothermic ; hypothermic ; liver transplant ; survival ; ustekinumab ; perianal fistula ; radiological fistula remission ; metastatic pancreatic carcinoma ; FOLFIRINOX ; sarcopenia ; oxaliplatin ; L3 skeletal muscle index ; percutaneous endoscopic gastrostomy ; prognostic factor ; bic Book Industry Communication::M Medicine
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies.
    Keywords: ciguatoxins ; HRMS ; Q-TOF ; ciguatera poisoning ; C-CTX1 ; fragmentation pathways ; maitotoxins ; Gambierdiscus ; Fukuyoa ; LC-MS/MS ; QToF ; neuroblastoma cell assay ; matrix effect ; ciguatera monitoring ; SPATT passive samplers ; HP20 resin ; CBA-N2a ; WS artificial substrate ; qPCR ; HTS metabarcoding ; ciguatera ; ciguatoxin ; cytotoxicity assay ; ELISA ; HPLC ; immunoassay ; mouse bioassay ; receptor-binding assay ; ciguatoxins (CTXs) ; neuroblastoma cell-based assay (CBA) ; immunosensor ; pacific ciguatoxins ; natural product ; polycyclic ether ; ring-closing metathesis ; Tsuji-Trost allylation ; French Polynesia ; epidemiology ; toxicological analyses ; risk management ; climate change ; Gambierdiscus polynesiensis ; toxin profile ; nitrate ; urea ; culture medium acidification ; CTX1B ; 52-epi-54-deoxyCTX1B ; 54-deoxyCTX1B ; Dictyota ; Caribbean ; dinoflagellate ; benthic algae ; algal toxin ; harmful algal bloom ; the Indian Ocean ; Arabian sea ; Kuwait bay ; Aden Gulf ; Red Sea ; Gulf of Aqaba ; Andaman Sea ; Bay of Bengal ; seafood safety ; foodborne disease ; experimental exposure ; lionfish ; trophic transfer ; toxin accumulation ; Selvagens Islands ; morphology ; phylogeny ; benthic dinoflagellate ; Beibu Gulf ; Chinese waters ; least absolute shrinkage and selection operator ; machine learning ; data science ; medical informatics ; survival analysis ; foodborne diseases ; Ciguatera Fish Poisoning ; digital technologies ; open data ; risk analysis ; marine biotoxins ; Lagodon rhomboides ; pinfish ; bioaccumulation ; depuration ; Caribbean ciguatoxin ; growth dilution ; model ; kinetics ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 95
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Billions of people suffer from dental problems. Paradoxically, the deteriorating state of teeth is accompanied by the ever-increasing desire to preserve the best facial appearance, which is significantly influenced by teeth aesthetics. This favors the development of dental materials and manufacturing technologies for dental prosthetics, needed to achieve expected effects of clinical treatment.This reprint focus on enhancing antimicrobial and mechanical properties of polymeric materials and composites for dentistry. In recent years, special attention has been focused on the possibility of giving materials new or improved properties by the introduction of nano or submicron size additives, fibers or whiskers. Using agents such as natural oils to enhance antimicrobial properties remains an exciting idea. Another area of research is the application of antibacterial monomers, which can be copolymerized in resins to kill oral pathogenic microflora. The use of new monomers or new compilations of various monomers to improve mechanical properties has also aroused interest. In addition, we are currently looking for new data regarding colonization of dental materials by pathogenic microbes and their influence on the other properties. Further, there are many new commercially available materials which should be investigated to verify their properties, which is important from the point of view of clinical practice. Original new research and reviews related to any of the topics mentioned above indicate the current directions of development of dental materials. We hope that the presented work will be of interest to readers.
    Keywords: dental cements ; ethanol ; water ; resistance ; DTS ; Vickers hardness ; dental materials ; dimethacrylates ; polymer networks ; structure ; morphology ; degree of conversion ; crosslink density ; physical crosslinking ; hydrogen bonds ; mechanical properties ; water sorption ; polymethyl methacrylate ; denture ; antibacterial properties ; silver ; sorption ; solubility ; wear resistance ; FRC ; bonding ; technique ; fiber ; reinforced ; composite ; spot ; mechanical ; deflection ; orthodontics ; brushing ; wear ; retainer ; splint ; load ; direct pulp capping ; indirect pulp capping ; ProRoot MTA ; MTA Angelus ; retroMTA ; biodentine ; theraCal LC ; ACTIVA BioACTIVE ; vital pulp therapy ; glass fiber ; composite post ; endodontic therapy ; etching ; post and core technique ; silane ; glass-ionomer cements ; resin-modified ; fibre ; reinforcement ; nanoparticles ; testing ; strength ; P2O5-bioglass ; zirconia ; melt-quenching ; SBF ; hydroxyapatite ; in vitro bioactivity ; essential oils ; oral pathogens ; antibacterial activity ; S. mutans ; L. acidophilus ; C. albicans ; antifungal activity ; resin composite ; wettability ; biofilm formation ; cytotoxicity ; polymers ; antimicrobial properties ; infiltrants ; metronidazole ; dental ceramics ; spectroscopy ; IR ; FT-IR ; Raman spectroscopy ; UV-Vis ; X-ray spectroscopy ; XRF ; XRD ; MS ; dental resins ; UDMA ; Bis-GMA ; Bis-EMA ; TEGDMA ; hardness ; water absorption ; water dissolution ; CAD-CAM ; inlay ; lithium disilicate ; zirconium dioxide ; root caries ; infiltration ; microstomatology ; adhesive ; bracket ; dentures ; denture adhesives ; human fibroblasts ; composite resins ; Streptococcus mutans ; dental caries ; bacterial adhesion ; oleic acid ; PMMA ; filamentation ; biofilm ; antimicrobial surface ; Candida albicans ; colonization ; penetration ; dimethacrylate copolymers ; quaternary ammonium methacrylates ; urethane-dimethacrylates ; photocurable copolymers ; water behavior ; thermoplastic materials ; laboratory protocol ; texture ; roughness ; biomaterial ; polymer ; microbial degradation ; artificial saliva ; mucins ; n/a ; bic Book Industry Communication::M Medicine
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  • 96
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: In this Special Issue, we sought advanced knowledge in both basic and clinical research presented in original articles and comprehensive reviews highlighting the latest advances in MCC. Articles focus on but were not restricted to the molecular basis of the disease, translational investigations of biomarkers for prospective clinical applications, and innovative diagnostic and therapeutic approaches in MCC.
    Keywords: miR-375 ; antagomiRs ; Merkel cell carcinoma ; Hippo signaling ; focal adhesion ; diagnosis ; treatment ; review ; guideline ; Merkel cell polyoma virus ; tumor microenvironment ; CD8 lymphocytes ; ulceration ; E-cadherin ; artesunate ; MCC ; polyomavirus ; ferroptosis ; radiation therapy ; immunotherapy ; surgical intervention ; survival ; multidisciplinary communication ; biomarkers ; cell tropism ; signaling pathways ; therapy ; transgenic mice ; tumorigenesis ; histogenesis ; ATOH1 ; GLI1 ; sonic hedgehog ; hair follicle ; Merkel cell polyomavirus ; skin carcinogenesis ; T antigens ; human polyomaviruses ; DNA tumor viruses ; viral oncoproteins ; merkel cell carcinoma ; merkel cell polyoma virus ; sex ; radiotherapy ; UV ; cell line ; MYC ; TP53 ; RB1 ; whole-exome ; significantly mutated genes ; copy number variation ; virus positive Merkel cell carcinoma ; virus negative Merkel cell carcinoma and copy number variant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 97
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: In the treatment of acute stroke, thrombolysis and thrombectomy have proven to be highly effective. Many patients have seen significant improvement after reperfusion therapy. This reprint aims to address current knowledge gaps and promote advancements in the use of thrombolysis and thrombectomy for the treatment of acute ischemic stroke.
    Keywords: ischemic stroke ; acute kidney injury ; contrast media ; endovascular treatment ; outcome ; hyperglycemia ; acute ischemic stroke ; large vessel occlusion ; mechanical thrombectomy ; stroke ; ischemia ; machine learning ; cerebral infarction ; biomarkers ; recanalization therapy ; reperfusion ; temperature ; time to admission ; prehospital delay ; prior stroke ; basilar artery ; brain ischemia ; intracranial atherosclerosis ; embolism ; infarction ; clinical symptoms ; intravenous thrombolysis ; endovascular therapy ; recanalization times ; clinical outcome ; hypoperfusion index ratio ; collateral circulation ; collateral scoring ; CTA ; CTP ; thrombolysis ; C-reactive protein ; white blood cell count ; prognosis ; hypoperfusion ; collaterality ; thrombectomy ; frailty ; elderly patients ; hospital frailty risk score ; acute stroke ; perfusion imaging ; CT perfusion ; MR perfusion ; RAPID ; fasting hyperglycemia ; fasting normoglycemia ; long-term outcome ; hemorrhagic transformation ; parenchymal hematoma ; GWAS ; single nucleotide variants ; anterior circulation ; bridging therapy ; recanalization ; stroke risk score ; COVID-19 ; Lithuania ; reperfusion therapies ; outcomes ; safety ; prehospital stroke diagnosis ; ultrasound ; brain perfusion ; SONAS® ; prehospital stroke scales ; point-of-care diagnostics ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 98
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    UGA Éditions
    Publication Date: 2024-04-05
    Description: Comment analyser les interactions verbales entre enfants lors des ateliers de philosophie ? C’est toute l’ambition de cet ouvrage inter­disciplinaire qui rassemble des contributions de chercheurs en sciences du langage, philosophie, psychologie, ergonomie, sciences de l’éducation et en communication, dont les perspectives croisées éclairent un même corpus de pratiques de Philosophie pour enfants. Les disciplines de recherche qui s’intéressent au raisonnement, à l’argumentation, à la pensée ou encore au développement langagier pourront s’emparer de ces maté­riaux issus de captations vidéos de ces discussions philosophiques. Les doctorants et étudiants en master y trouveront des approches et méthodes variées pouvant être appliquées à un même corpus. L’ouvrage se présente ainsi comme une « métho­dologie par l’exemple » qui analyse une activité empirique, telle qu’elle se réalise et non pas telle qu’on voudrait qu’elle se réalise.
    Keywords: Analyse pluridisciplinaire ; Argumentation ; Conceptualisation ; Corpus ; Dialogue ; Discussion philosophique ; Multimodalité ; Philosophie ; Pragmatique ; Psychologie ; Raisonnement ; Sciences de l'éducation ; Sciences du langage ; Sémantique ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
    Language: French
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  • 99
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: As Editor-in-Chief of the journal Diabetology, I am pleased to announce that the Special Issue “Diabetology: Feature Papers 2022” has now been published as a reprint. Diabetology (ISSN 2673-4540) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to the epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In this Special Issue, “Feature Papers”, we aimed to publish outstanding contributions in the main fields covered by the journal, which will make a great contribution to the community. This reprint covers the whole spectrum of diabetology from risk screening, risk markers, pathways of disease in type 1 diabetes and insulin treatment, and management of the disease and comorbidities.
    Keywords: older people ; diabetes mellitus ; management ; insulin therapy ; frailty ; sarcopenia ; type 1 diabetes ; type 2 diabetes ; insulin ; beta cell preservation ; verapamil ; thioredoxin-interacting protein (TXNIP) ; Chronic Care Model ; self-management of type 2 diabetes ; chronic disease ; healthcare system of Pakistan ; patients’ quality of life ; obstructive sleep apnoea ; DM ; obesity ; inflammation ; polysomnography ; coronavirus disease 2019 ; COVID-19 ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; diabetes ; diabetic ketoacidosis ; DKA ; hyperglycemia ; mortality ; innate immunity ; cytokine storm ; angiotensin-converting enzyme 2 ; pancreatic β-cell damage ; pediatrics ; HbA1c ; telemedicine ; continuous glucose monitoring ; prediabetes ; liver enzymes ; rhenium (V) compound ; triglycerides ; NAFLD ; fructose ; injection technique ; lipohypertrophy ; sodium glucose co-transporter 2 (SGLT2) inhibitors ; nocturia ; sodium intake ; key informant interviews ; prevention of type 2 diabetes ; National DPP ; DSMES ; telehealth ; provider experiences ; lipodystrophy ; clinical detection ; recommendations ; rehabilitation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Electronic cigarettes (ECs) have been present on the consumer market for over a decade, and the number of related scientific publications in the PubMed database has now exceeded seven thousand. Despite the number of publications, there is still no consensus in the scientific community regarding their safety. However, it should be emphasized that a comparison of equivalent quantities of tobacco smoke and the aerosol produced from e-cigarettes showed that there was a significantly lower quantity of toxic compounds in the aerosol compared with the tobacco smoke. Therefore, the use of ECs could be seen as a way of reducing the health damage to cigarette smokers who cannot or are unwilling to quit using conventional methods. In addition, randomized studies are emerging suggesting that ECs could be useful in smoking cessation. On the other hand, ECs are now widely used among adolescents and may pose a serious risk of future nicotine dependence and health problems in this population, as they counteract their advantages in the population gained from smokers who quit using them. Therefore, as most authors stress, further research that will convincingly resolve the current controversies is needed. Clinicians urgently need evidence-based knowledge to better inform their patients about the use of these emerging tobacco products as a harm-reduction strategy, and regulators should regulate these products in ways that best serve public health, especially taking the youth population into account.
    Keywords: e-cigarettes ; global health ; vaping ; tobacco smoke ; toxicants ; cessation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
    Language: English
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