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  • Polymer and Materials Science  (112,478)
  • Animals  (27,852)
  • Biochemistry and Biotechnology  (13,095)
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  • 1
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    Impacts of Molecular Structure on Nucleic Acid-Protein Interactions (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-11
    Description: Interactions between nucleic acids and proteins are essential requirements for the viability of cellular life because they are indispensable for many basic biological processes. DNA is typically presented as a specific double-stranded helical structure, but nucleic acids have great structural flexibility. Current knowledge demonstrates that the structural conformations of nucleic acids play critical roles in protein–DNA interactions. This book presents a collection of research findings published in the Special Issue of the International Journal of Molecular Sciences, titled “Impacts of Molecular Structure on Nucleic Acid-Protein Interactions”.The breadth of research findings reported here demonstrates that the structural flexibility of nucleic acids plays critical roles in their interactions with proteins, with important implications across a range of human diseases, including cancer and some infectious diseases.Prof. Richard BowaterUniversity of East Anglia, Norwich, United KingdomProf. Václav BrázdaInstitute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic
    Keywords: DNA ; RNA ; protein binding ; G-quadruplex ; triplex ; i-motif ; Z-DNA ; Z-RNA ; cruciform ; amino acid composition ; COVID-19 ; SARS-CoV-2 ; coronavirus ; CNBP ; virus ; bioinformatics ; coevolution ; host ; dsDNA ; G4Hunter ; evolution ; plant science ; nucleic acids ; circular dichroism ; UV light ; ligand ; rhodamine ; thiazole orange ; thioflavin T ; p53 ; aging ; longevity ; comparative analysis ; protein sequence ; Drosophila ; polytene chromosomes ; Canton-S ; agnostic ; ectopic pairing ; 1.688 repeats ; 372-bp repeats ; fragile X-associated primary ovarian insufficiency (FXPOI) ; fragile X-associated tremor/ataxia syndrome (FXTAS) ; fragile X syndrome (FXS) ; repeat instability ; repeat expansion ; chromosome fragility ; RNA gain-of-function ; repeat-associated non-AUG (RAN) translation ; repeat-mediated gene silencing ; Zα domain ; orthogonal representation ; algorithm ; toehold switch ; arithmetic operation ; RNA–RNA interaction ; molecular computing ; reversible computing ; DNA base sequence ; DNA structure ; DNA supercoiling ; epigenetics ; genome stability ; inverted repeat ; replication ; transcription ; nucleic acid–protein interactions ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology
    Language: English
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  • 2
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    Evolution, Composition and Regulation of Supernumerary B Chromosomes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: Supernumerary B chromosomes (Bs) are dispensable genetic elements found in thousands of species of plants and animals, and some fungi. Since their discovery more than a century ago, they have been a source of puzzlement, as they only occur in some members of a population and are absent from others. When they do occur, they are often harmful, and in the absence of “selfishness”, based on mechanisms of mitotic and meiotic drive, there appears to be no obvious reason for their existence. Cytogeneticists have long wrestled with questions about the biological existence of these enigmatic elements, including their lack of any adaptive properties, apparent absence of functional genes, their origin, sequence organization, and co-evolution as nuclear parasites. Emerging new technologies are now enabling researchers to step up a gear, to look enthusiastically beyond the previous limits of the horizon, and to uncover the secrets of these “silent” chromosomes. This book provides a comprehensive guide to theoretical advancements in the field of B chromosome research in both animal and plant systems.
    Keywords: QH301-705.5 ; Q1-390 ; parent-of-origin effects ; fluorescent in situ hybridization ; coverage ratio analysis ; n/a ; ribosomal DNA ; reactivation ; cytogenetics ; epigenetics ; heterochromatin ; interphase nucleus ; whole genome resequencing ; transmission ; grasshoppers ; genome instability ; dot-like (micro) Bs ; ?s ; B chromosome ; supernumerary elements ; transcription of heterochromatin ; maternal X chromosome ; supernumerary chromosome ; population analysis ; supernumerary ; repeat clusters ; extra chromosomes ; genes ; tandem repeats ; B morphotypes ; repetitive DNA ; repetitive elements ; DNA copy number variation ; chromosome polymorphism ; satellite DNA ; mammals ; maize B chromosome ; additional chromosomes ; inactivation ; drive ; B chromosomes ; FISH (fluorescence in situ hybridisation) ; organelle DNA ; Orthoptera ; origin ; supernumerary chromosomes ; karyotype evolution ; GISH (genomic in situ hybridisation) ; DNA composition ; de novo centromere formation ; genomics ; paternal X chromosome ; euchromatin degradation ; supernumerary chromosomal segments (SCS) evolution ; centromere ; sSMC ; Prospero autumnale complex ; next-generation sequencing ; Drosophila ; host/parasite interaction ; Apodemus peninsulae ; genome evolution ; evolution ; teleost ; chromosome evolution ; microdissected DNA probes ; controlling element ; mobile element ; RNA-Seq ; karyotypes ; karyotypic characteristics ; RepeatExplorer ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 3
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    Ontogeny and Phylogeny of Brain Barrier Mechanisms (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: The brain functions within an internal environment that is determined and controlled by morphological structures and cellular mechanisms present at interfaces between the brain and the rest of the body. In vertebrates these interfaces are across cerebral blood vessels (blood-brain barrier) choroid plexuses (blood-cerebrospinal fluid barrier) and pia-arachnoid. There is a CSF-brain barrier in the neuroepithelium lining the ventricular system that is only present in embryos. There is now substantial evidence that many brain barrier mechanisms develop early and that in some cases they are functionally more active and even more specialized compared to adult barriers. Therefore barriers in developing brain should be viewed as adapted appropriately for the growing brain and not, as is still widely believed, immature. Considerable advances in our understanding of these barrier mechanisms have come from studies of the developing brain and invertebrates. A striking aspect, to be highlighted in this special edition, is that many of the molecular mechanisms in these very diverse species are similar despite differences in the cellular composition of the interfaces. This Frontiers Topic comprises articles in three sections: Original studies, Reviews and Myths & Misconceptions. Original articles provide new information on molecular and cellular barrier mechanisms in developing brains of primates, including human embryos (Brøchner et al., Ek et al., Errede et al.), rodents (Bauer et al., Liddelow, Strazielle & Ghersi-Egea, Saunders et al., Whish et al.), chick (Bueno et al.) and zebrafish (Henson et al.) as well as studies in drosophila (Hindle & Bainton, De Salvo et al., Limmer et al.). The Reviews section includes evolutionary perspectives of the blood-brain and blood-CSF barriers (Bueno et al., Bill & Korzh). There are also detailed reviews of the current state of understanding of different interfaces and their functional mechanisms in developing brain (Bauer et al., Strazielle & Gjersi-Egea, Liddelow, Richardson et al., Errede et al., Henson et al., Brøchner et al.) and in invertebrates (Hindle & Bainton, De Salvo et al., Limmer et al). Different aspects of the relationship between properties of the internal environment of the brain and its development are discussed. (Stolp & Molnar, Johansson, Prasongchean et al.). A neglected area, namely barriers over the surface of the brain during development is also covered (Brøchner et al.). Clinically related perspectives on barrier disruption in neonatal stroke are provided by Kratzer et al. and other aspects of dysfunction by Morretti et al. and by Palmeta et al. on the continuing problem of bilirubin toxicity. Progress in this field is hampered by many prevailing myths about barrier function, combined with methodologies that are not always appropriately selected or interpreted. These are covered in the Misconceptions, Myths and Methods section, including historical aspects and discussion of the paracellular pathway, a central dogma of epithelial and endothelial biology (Saunders et al.) and a review of markers used to define brain barrier integrity in development and in pathological conditions (Saunders et al.). Use of inappropriate markers has caused considerable confusion and unreliable interpretation in many published studies. Torbett et al. deal with the complexities of the new field of applying proteomics to understanding blood-brain barrier properties as do Huntley at al. with respect to applying modern high throughput gene expression methods (Huntley et al.). The Editorial summarizes the contributions from all authors. This includes mention of some the main unanswered but answerable questions in the field and what the impediments to progress may be.
    Keywords: RC321-571 ; Q1-390 ; zebra fish ; development ; Influx mechanisms ; Tight Junctions ; Drosophila ; Efflux mechanisms ; blood-CSF barrier ; Choroid Plexus ; Blood-Brain Barrier ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 4
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    Neural Circuits: Japan (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: This Frontiers Research Topic on ‘Neural Circuits: Japan’ explores the diversity of neural circuit research occurring across Japan by innovative researchers using cutting-edge approaches. This issue has brought together papers revealing the development, structure, and physiology of neuronal circuits involved in sensory perception, sleep and wakefulness, behavioral selection, and motor command generation in a range of species from the nematode to the primate. Like the USA and Europe, Japan is now making a strong effort to elucidate neural circuit function in diverse organisms by taking advantages of optogenetics and innovative approaches for gene manipulation, traditional physiological and anatomical approaches, and neural pathway-selective inactivation techniques that have recently been developed in Japan.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Drosophila ; Olfactory Bulb ; Basal Ganglia ; Hypothalamus ; Neocortex ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 5
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    Virus Bioinformatics (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.
    Keywords: QH301-705.5 ; Q1-390 ; BBB ; recombination ; software ; APMV ; AquaDiva ; horizontal gene transfer ; sequence interpretation ; structurally homogenous ; CVI988/Rispens ; DFT ; eukaryogenesis ; fluorescent reporter protein ; parallel reaction monitoring ; transcriptomics ; splicing ; Rickettsia ; minor capsid protein ; flavivirus ; DWT ; RNA viruses ; data compression ; DNA replication ; influenza A ; virus diagnostics ; quasispecies ; mRNA structure ; systems virology ; virus bioinformatics ; metagenomics ; drug resistance ; nasopharynx ; image quantification ; infection ; primary B cells ; non-coding RNA ; transcriptome ; RB1B ; virus ; interferon-stimulated genes (ISG) ; pandoravirus ; virus-host interaction ; secondary structure ; bivalve ; ICP0 ; assembly ; MSA ; variant calling ; translation machinery ; gram-positive bacteria ; virosphere ; viral mRNA ; NCLDV ; sncRNA ; structurally related ; cellular immunity ; Amebae viruses ; genome evolution ; groundwater ; capsid protein ; HPV58 ; RNA structure ; polyomavirus ; Mimivirus ; PAA ; honey bees ; Hepatitis C virus ; compressive genomics ; Yellow Fever Virus ; poxvirus ; ADAR ; virome ; endogenous viral elements ; giant virus ; structure database ; RNA-seq ; deep sequencing ; viral evolution ; bovine soft palate ; deformed wing virus ; virus-to-host gene transfer ; ASFV ; virus proteomics ; RNAi ; polycistronic viral transcripts ; complex networks analysis ; mimivirus ; TLR agonist ; time series ; mRNA families ; foot-and-mouth disease virus (FMDV) ; comparative genomics ; virus dynamics modeling ; viral metagenome ; subVOG ; bioinformatics ; viral taxonomy ; sequencing library preparation ; virus classification ; alignment ; targeted proteomics ; prophylaxis ; bacteriophage ; dsdna viruses ; taxonomic classification ; Marek’s disease virus (MDV) ; Coxsackievirus B4 ; hepatitis C virus ; mass spectrometry ; data transformation ; Base-By-Base ; data analysis ; peptide selection ; proteomics ; mitochondria ; Drosophila ; ori ; HMM ; codon frequency distribution ; RNAseq ; protein domains ; innate immune system ; tobacco mosaic virus ; apiary pests ; virology ; virus genomics ; chemical organization theory ; aquifer ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 6
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    Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: Neurodegenerative diseases are the most frequent cause of dementia, representing a burden for public health systems (especially in middle and middle-high income countries). Although most research on this issue is concentrated in first-world centers, growing efforts in South America are affording important breakthroughs. This emerging agenda poses new challenges for the region but also new opportunities for the field. This book aims to integrate the community of experts across the globe and the region, and to establish new challenges and developments for future investigation. We present research focused on neurodegenerative research in South America. We introduce studies assessing the interplay among genetic, neural, and behavioral dimensions of these diseases, as well as articles on vulnerability factors, comparisons of findings from various countries, and works promoting multicenter and collaborative networking. More generally, our book covers a broad scope of human-research approaches (behavioral assessment, neuroimaging, electromagnetic techniques, brain connectivity, peripheral measures), animal methodologies (genetics, epigenetics, proteomics, metabolomics, other molecular biology tools), species (all human and non-human animals, sporadic, and genetic versions), and article types (original research, review, and opinion papers). Through this wide-ranging proposal, we hope to introduce a fresh approach to the challenges and opportunities of research on neurodegeneration in South America.
    Keywords: RC321-571 ; Q1-390 ; South America ; Multicenter research ; Neurodegenerative Diseases ; Neurosciences ; Public Health ; Animals ; Clinical Protocols ; Research ; Human Experimentation ; Dementia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 7
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    Biogenic Amines and Neuromodulation of Animal Behavior, 2nd Edition (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: Since Erspamer and Boretti, 1951 first described the biogenic amine octopamine in the octopus salivary gland as a molecule with “adrenaline-like” action, decades of extensive studies demonstrated the important role octopamine and its precursor tyramine play in invertebrate physiology and behavior. This book contains the latest original research papers on tyramine/octopamine and their receptors in different neuronal and non-neuronal circuits of insects. 〈/p〉Additonally, this book elucidates in detail the latest research on the function of other biogenic amines and their receptors, such as dopamine and serotonin in insects and mice. The reviews in this book summarize the most recent research on the role of biogenic amines in insect antennae, synaptic development, and behavioral modulation by spontaneous dopamine release in Drosophila. Finally, one perspective paper discusses the evolution of social behavior and biogenic amines. 〈br〉〈br〉We recommend this book for all scholars interested in the latest advanced research on the role of biogenic amines in animal behavior. 〈br〉〈br〉ITS dedicates the topic to her teacher, Plotnikova Svetlana Ivanovna (1922-2013).
    Keywords: RC321-571 ; Q1-390 ; octopamine ; Apis mellifera ; olfactory learning and memory ; serotonin ; G-protein coupled receptors (GPCR) ; type I and II synaptic boutons ; Drosophila ; neural circuits ; tyramine ; dopamine ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 8
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    Neuropharmacological, Neurobiological and Behavioral Mechanisms of Learning and Memory (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: drugs ; Behavior ; Memory tasks ; pre-clinical ; clinical ; Humans ; Animals ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 9
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    Animals and Inequality in the Ancient World (2021)
    University Press of Colorado | University Press of Colorado
    Details
    Publication Date: 2024-04-02
    Description: Animals and Inequality in the Ancient World explores the current trends in the social archaeology of human-animal relationships, focusing on the ways in which animals are used to structure, create, support, and even deconstruct social inequalities. The authors provide a global range of case studies from both New and Old World archaeology—royal Aztec dog burial, the monumental horse tombs of Central Asia, and the ceremonial macaw cages of ancient Mexico among them. They explore the complex relationships between people and animals in social, economic, political, and ritual contexts, incorporating animal remains from archaeological sites with artifacts, texts, and iconography to develop their interpretations. Animals and Inequality in the Ancient World presents new data and interpretations that reveal the role of animals, their products, and their symbolism in structuring social inequalities in the ancient world. The volume will be of interest to archaeologists, especially zooarchaeologists, and classical scholars of pre-modern civilizations and societies.  Contributors: Alejandra Aguirre Molina, Benjamin S. Arbuckle, Levent Atici, Douglas V. Campana, Roderick Campbell, Ximena Chá­vez Balderas, Pam J. Crabtree, Susan D. deFrance, Kitty F. Emery, Abigail Holeman, H. Edwin Jackson, Leonardo López Lujá­n, Michael MacKinnon, Arkadiusz Marciniak, Sue Ann McCarty, Neil L. Norman, Gilberto Perez, Bernardo Rodriguez, William A. Saturno, Ashley E. Sharpe, Nawa Sugiyama, Charlotte K. Sunseri, Naomi Sykes, Fabiola Torres, Raul Valadez, Norma Valentin Maldonado, Adam S. Watson, Joshua Wright, Belem Zuniga-Arelleno
    Keywords: History ; Ancient ; Social Science ; Archaeology ; Nature ; Animals ; thema EDItEUR::N History and Archaeology::NH History::NHC Ancient history ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WN Nature and the natural world: general interest::WNC Wildlife: general interest
    Language: English
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  • 10
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    Advances in Molecular Genetics of Brain Tumors (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2024-04-02
    Description: This reprint encompasses a number of articles that focus on the molecular blueprint of brain tumors. A collection of relevant papers in the rapidly expanding field of brain tumor molecular genetics broadens our knowledge about the biology of brain tumors, and inspires further studies that will improve the diagnosis and clinical management of brain tumors. Due to the great heterogeneity of brain tumors it is important to research and understand every aspect of their initiation, progression and metastasis in order to design better diagnostic and therapeutic approaches for their clinical management and patient benefit.
    Keywords: DVL1 ; PDZ domain ; β-catenin ; Wnt signaling pathway ; intracranial meningioma ; microglia ; glioblastoma ; olfactomedin-like 3 ; TGFβ ; Glioblastoma ; Doublecortin ; DCX ; OLIG2 ; NES ; single cell RNA-seq ; immunohistochemistry ; immunofluorescence ; brain tumours ; brain tumor ; GBM ; cancer stem cell ; BIRC3 ; BMP4 ; stemness ; pediatric glioblastoma ; temozolomide ; NKCC1 ; KCC2 ; EZH2 ; PCNA ; CAM ; cancer ; neurodegeneration ; glioma ; Drosophila ; disease model ; PI3K ; EGFR ; genetics ; schwannoma ; NF2 ; bevacizumab ; VEGF ; SH3PXD2A-HTRA1 fusion ; molecular targeted therapy ; IDH1 mutation ; redox household ; nicotinamide phosphoribosyltransferase ; NAD+ synthesis ; cancer metabolism ; pentose phosphate pathway ; cell proliferation ; miRNA ; hypoxia ; angiogenesis ; treatment-related changes ; true progression ; pseudoprogression ; radiation necrosis ; biomarkers ; 18F-FET PET ; IDH mutation ; functional precision oncology ; drug sensitivity ; prognostic biomarkers ; systematic review ; meta-analysis ; cancer pathway ; mRNA ; multicriterial analysis ; n/a ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JN Education
    Language: English
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