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  • Humans  (741)
  • LUNAR AND PLANETARY EXPLORATION
  • 2020-2024
  • 2000-2004  (741)
  • 2002  (741)
  • 1
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    The paucity of grants among young scientists (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McColl, Damian J -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2328-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12498167" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Career Mobility ; *Education, Graduate ; Financing, Government ; Humans ; *National Institutes of Health (U.S.) ; *Research Personnel ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The paucity of grants among young scientists (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Djerassi, Carl -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2328-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12498165" target="_blank"〉PubMed〈/a〉
    Keywords: Financing, Government ; Humans ; *National Institutes of Health (U.S.) ; *Research Personnel ; *Research Support as Topic ; United States ; Universities
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The paucity of grants among young scientists (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nizami, Lance -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2328-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12498166" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Science Disciplines/*education ; Career Mobility ; *Education, Graduate ; Humans ; *Research Personnel ; Research Support as Topic ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The discovery of the electric shock (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holst, Bodil -- Zimmer, N -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2327-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12498164" target="_blank"〉PubMed〈/a〉
    Keywords: Electroshock/*history ; History, 18th Century ; Humans ; Static Electricity/*history
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Is schizophrenia linked to chromosome 1q? (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-24
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276596/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276596/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bassett, Anne S -- Chow, Eva W C -- Vieland, Veronica J -- Brzustowicz, Linda -- 38099/Canadian Institutes of Health Research/Canada -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2277; author reply 2277.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Torontoand Clinical Genetics Research Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada. anne.bassett@utoronto.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12494945" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosomes, Human, Pair 1/*genetics ; Female ; Genetic Heterogeneity ; *Genetic Linkage ; *Genetic Predisposition to Disease ; Humans ; Lod Score ; Male ; Pedigree ; Research Design ; Schizophrenia/ethnology/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Coordinated nonvectorial folding in a newly synthesized multidomain protein (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: The low-density lipoprotein receptor (LDL-R) is a typical example of a multidomain protein, for which in vivo folding is assumed to occur vectorially from the amino terminus to the carboxyl terminus. Using a pulse-chase approach in intact cells, we found instead that newly synthesized LDL-R molecules folded by way of "collapsed" intermediates that contained non-native disulfide bonds between distant cysteines. The most amino-terminal domain acquired its native conformation late in folding instead of during synthesis. Thus, productive LDL-R folding in a cell is not vectorial but is mostly posttranslational, and involves transient long-range non-native disulfide bonds that are isomerized into native short-range cysteine pairs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jansens, Annemieke -- van Duijn, Esther -- Braakman, Ineke -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2401-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Bio-Organic Chemistry 1, Bijvoet Center for Biomolecular Research, University of Utrecht, Padualaan 8, 3584 CH Utrecht, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493918" target="_blank"〉PubMed〈/a〉
    Keywords: Cysteine/chemistry ; Dithiothreitol ; Endoplasmic Reticulum/metabolism ; Epitopes ; Glycosylation ; Golgi Apparatus/metabolism ; HeLa Cells ; Humans ; Ligands ; Molecular Weight ; Oxidation-Reduction ; Precipitin Tests ; Protein Binding ; Protein Biosynthesis ; Protein Denaturation ; *Protein Folding ; *Protein Structure, Tertiary ; Protein Transport ; Receptors, LDL/*chemistry/genetics/immunology/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Animal models. To build a better mouse cage (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2321.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493895" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation ; Animals ; *Animals, Laboratory ; *Behavior, Animal ; Environment ; *Housing, Animal ; Humans ; *Mice ; Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Portraits of science. A Polish, Jewish scientist in 19th-century Prussia (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lagunoff, David -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2331.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, St. Louis University School of Medicine, St. Louis, MO 63104, USA. lagunofd@slucare1.sluh.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Biology/*history ; *Cell Division ; *Cell Physiological Phenomena ; Electric Stimulation Therapy/history ; Embryology/history ; Germany ; History, 19th Century ; Humans ; Judaism ; Neoplasms/pathology ; Nerve Fibers/ultrasonography ; Neuromuscular Diseases/history/therapy ; Neurons/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Finding genes that underlie complex traits (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: Phenotypic variation among organisms is central to evolutionary adaptations underlying natural and artificial selection, and also determines individual susceptibility to common diseases. These types of complex traits pose special challenges for genetic analysis because of gene-gene and gene-environment interactions, genetic heterogeneity, low penetrance, and limited statistical power. Emerging genome resources and technologies are enabling systematic identification of genes underlying these complex traits. We propose standards for proof of gene discovery in complex traits and evaluate the nature of the genes identified to date. These proof-of-concept studies demonstrate the insights that can be expected from the accelerating pace of gene discovery in this field.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glazier, Anne M -- Nadeau, Joseph H -- Aitman, Timothy J -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2345-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, Ducane Road, London W12 0NN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493905" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Chromosome Mapping ; Genetic Linkage ; *Genetic Predisposition to Disease ; Genetic Variation ; Humans ; *Multifactorial Inheritance ; Mutation ; Phenotype ; Plants/genetics ; *Quantitative Trait Loci ; *Quantitative Trait, Heritable ; Saccharomyces cerevisiae/genetics ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Breakthrough of the year. The runners-up (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2002 Dec 20;298(5602):2297-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493876" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astronomical Phenomena ; Astronomy ; Biological Evolution ; Cosmic Radiation ; Elementary Particles ; Genome ; Hominidae ; Humans ; Ion Channels/physiology ; Lasers ; Light ; Microwaves ; Motion Pictures as Topic ; Optics and Photonics ; Retinal Ganglion Cells/physiology ; Rod Opsins/physiology ; *Science ; Sequence Analysis, DNA ; Temperature ; Tomography/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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