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  • 1
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    Molecular evolution. Genome duplications: the stuff of evolution? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pennisi, E -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2458-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752552" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Evolution ; *Evolution, Molecular ; Fishes/genetics ; Gene Dosage ; *Gene Duplication ; *Genome ; Genome, Human ; Genomics ; Humans ; Invertebrates/genetics ; Multigene Family ; Polyploidy ; Vertebrates/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Breakthrough of the year. Peering into 2002 (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2001 Dec 21;294(5551):2444.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752539" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomical Phenomena ; Astronomy ; Biochemical Phenomena ; Biochemistry ; Computer Simulation ; Embryo, Mammalian/cytology ; Genetics, Medical ; Humans ; Microscopy, Electron ; Optics and Photonics ; Proteins/physiology ; Proteome ; *Research ; *Science ; Stem Cells
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Breakthrough of the year. The year of living dangerously (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, D -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2443.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752537" target="_blank"〉PubMed〈/a〉
    Keywords: Anthrax ; Bioterrorism ; DNA Fingerprinting ; Humans ; International Cooperation ; Publishing ; *Research ; Research Support as Topic ; Security Measures/legislation & jurisprudence ; *Terrorism ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Global change. Sharing the garden (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Field, C B -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2490-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Carnegie Institution of Washington, Stanford, CA 94305, USA. chris@globalecology.stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752562" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture ; Atmosphere ; Climate ; Conservation of Natural Resources ; *Ecosystem ; Food ; Food Chain ; Forestry ; *Human Activities ; Humans ; Plant Development ; *Plants ; Statistics as Topic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Human appropriation of photosynthesis products (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: Previous global estimates of the human impact on terrestrial photosynthesis products depended heavily on extrapolation from plot-scale measurements. Here, we estimated this impact with the use of recent data, many of which were collected at global and continental scales. Monte Carlo techniques that incorporate known and estimated error in our parameters provided estimates of uncertainty. We estimate that humans appropriate 10 to 55% of terrestrial photosynthesis products. This broad range reflects uncertainty in key parameters and makes it difficult to ascertain whether we are approaching crisis levels in our use of the planet's resources. Improved estimates will require high-resolution global measures within agricultural lands and tropical forests.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rojstaczer, S -- Sterling, S M -- Moore, N J -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2549-52.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Hydrologic Science and Division of Earth and Ocean Sciences, Duke University, Durham, NC 27708, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752576" target="_blank"〉PubMed〈/a〉
    Keywords: *Agriculture ; Biomass ; Computer Simulation ; Conservation of Natural Resources ; *Ecosystem ; Food ; *Forestry ; Fresh Water ; *Human Activities ; Humans ; Monte Carlo Method ; Photosynthesis ; Plant Development ; *Plants/metabolism ; Probability ; Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Breakthrough of the year. Scorecard 2000 (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2001 Dec 21;294(5551):2445.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752540" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Body Patterning ; Communicable Diseases ; Elementary Particles ; Gene Silencing ; Humans ; Oceanography ; Rna ; *Research ; Research Support as Topic ; *Science ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Breakthrough of the year. The runners-up (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2001 Dec 21;294(5551):2443-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752538" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antineoplastic Agents/therapeutic use ; Axons/physiology ; Benzamides ; Carbon ; Climate ; Ecosystem ; Electronics ; Genome, Human ; Humans ; Imatinib Mesylate ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Physical Phenomena ; Physics ; Piperazines/therapeutic use ; Pyrimidines/therapeutic use ; Rna ; *Research ; *Science
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Biomedicine. Do G quartets orchestrate fragile X pathology? (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moine, H -- Mandel, J L -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2487-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉UPR9002 CNRS, 67084 Strasbourg Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752559" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Brain/metabolism ; Crystallography, X-Ray ; Fragile X Mental Retardation Protein ; Fragile X Syndrome/genetics/*metabolism ; Gene Expression Regulation ; Humans ; Mice ; Nerve Tissue Proteins/chemistry/genetics/*metabolism ; Nucleic Acid Conformation ; Oligonucleotide Array Sequence Analysis ; Protein Biosynthesis ; Protein Structure, Tertiary ; RNA, Messenger/*chemistry/genetics/*metabolism ; *RNA-Binding Proteins ; Synapses/physiology ; Untranslated Regions
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Scientific misconduct. Psychologist made up sex bias results (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Holden, C -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2457.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752550" target="_blank"〉PubMed〈/a〉
    Keywords: *Behavioral Research ; Canada ; Female ; History, 21st Century ; Humans ; Male ; *Prejudice ; *Psychology, Social ; Publishing ; *Scientific Misconduct ; Social Class ; United States ; United States Office of Research Integrity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    KLF6, a candidate tumor suppressor gene mutated in prostate cancer (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Narla, G -- Heath, K E -- Reeves, H L -- Li, D -- Giono, L E -- Kimmelman, A C -- Glucksman, M J -- Narla, J -- Eng, F J -- Chan, A M -- Ferrari, A C -- Martignetti, J A -- Friedman, S L -- 5 P30 HD28822/HD/NICHD NIH HHS/ -- CA78207/CA/NCI NIH HHS/ -- CA79918/CA/NCI NIH HHS/ -- DK37340/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2563-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, Room 1170F, Box 1123, New York, NY, 10029, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752579" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Amino Acid Substitution ; Animals ; Cell Division ; Cell Line ; Chromosome Mapping ; Chromosomes, Human, Pair 10/genetics ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclins/genetics/metabolism ; *Genes, Tumor Suppressor ; Genetic Heterogeneity ; Humans ; Kruppel-Like Transcription Factors ; Loss of Heterozygosity ; Male ; Mice ; Microsatellite Repeats ; *Mutation ; Mutation, Missense ; Proliferating Cell Nuclear Antigen/metabolism ; Promoter Regions, Genetic ; Prostatic Neoplasms/*genetics ; *Proto-Oncogene Proteins ; Trans-Activators/chemistry/*genetics/physiology ; Transcriptional Activation ; Tumor Cells, Cultured ; Up-Regulation ; Zinc Fingers
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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