ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Books
  • Articles  (4)
  • Binding Sites  (2)
  • aggregate model  (2)
  • Biology  (2)
  • Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics  (2)
  • 1
    facet.materialart.
    Unknown
    Circular RNAs are a large class of animal RNAs with regulatory potency (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-03-01
    Description: Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Memczak, Sebastian -- Jens, Marvin -- Elefsinioti, Antigoni -- Torti, Francesca -- Krueger, Janna -- Rybak, Agnieszka -- Maier, Luisa -- Mackowiak, Sebastian D -- Gregersen, Lea H -- Munschauer, Mathias -- Loewer, Alexander -- Ziebold, Ulrike -- Landthaler, Markus -- Kocks, Christine -- le Noble, Ferdinand -- Rajewsky, Nikolaus -- England -- Nature. 2013 Mar 21;495(7441):333-8. doi: 10.1038/nature11928. Epub 2013 Feb 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Systems Biology of Gene Regulatory Elements, Max-Delbruck-Center for Molecular Medicine, Robert-Rossle-Strasse 10, 13125 Berlin, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23446348" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Autoantigens/genetics/metabolism ; Binding Sites ; Brain/metabolism ; Caenorhabditis elegans/genetics/metabolism ; Cell Line ; Conserved Sequence ; Female ; *Gene Expression Regulation ; HEK293 Cells ; Humans ; Male ; Mice ; MicroRNAs/genetics/metabolism ; Nerve Tissue Proteins/genetics/metabolism ; RNA/genetics/*metabolism ; Zebrafish/embryology/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    New aspects of the single phase aggregate model for oriented polymers (1986)
    Springer
    Colloid & polymer science 264 (1986), S. 1010-1016 
    Details
    ISSN: 1435-1536
    Keywords: Oriented polymers ; elastic anisotropy ; aggregate model ; orientation parameters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A reinvestigation of the single phase aggregate model (SPAM) of Ward applied to the elastic properties of uniaxially oriented polymers is presented. It is shown that the Voigt and the Reuss orientation average of elastic constants can be represented as a linear transformation in a 5-dimensional vector space. The corresponding transformation matrix can be diagonalized, showing that the eigenvalues of this transformation are the orientation parametersP 0 =1,P 2 andP 4 . Taking advantage of this representation an easy test of applicability of the SPAM is proposed. Possibilities to evaluate the SPAM parameters are reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410318
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Structure and anisotropy in polycarbonate III. Study of elastic and optical properties of oriented samples with the method of high resolution Brillouin spectroscopy (1987)
    Springer
    Colloid & polymer science 265 (1987), S. 761-773 
    Details
    ISSN: 1435-1536
    Keywords: Polycarbonate ; oriented polymers ; elastic and optical anisotropy ; Brillouin spectroscopy ; aggregate model ; orientation parameters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract High resolution Brillouin spectroscopy (BS) has been used to investigate elastic and optical properties of uniaxially drawn samples of polycarbonate (PC). The results are discussed in the framework of the single phase aggregate model (SPAM) of Ward. According to a recently developed evaluation technique, the SPAM parameters of PC are determined, resulting in the following elastic constants of the structural units:c 33 0 =33 GPa,c 11 0 =7 GPa,c 13 0 =9.7 GPa,c 44 0 =1.4 GPa, andc 66 0 =1 GPa. A nearly quadratic dependence of the orientation parameterP 4 onP 3 results, which can be explained by a modified pseudoaffine deformation scheme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01418451
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    facet.materialart.
    Unknown
    The Mycobacterium tuberculosis regulatory network and hypoxia (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-07-05
    Description: We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration. Adaptations to hypoxia are thought to have a prominent role in M. tuberculosis pathogenesis. Using ChIP-Seq combined with expression data from the induction of the same factors, we have reconstructed a draft regulatory network based on 50 transcription factors. This network model revealed a direct interconnection between the hypoxic response, lipid catabolism, lipid anabolism and the production of cell wall lipids. As a validation of this model, in response to oxygen availability we observe substantial alterations in lipid content and changes in gene expression and metabolites in corresponding metabolic pathways. The regulatory network reveals transcription factors underlying these changes, allows us to computationally predict expression changes, and indicates that Rv0081 is a regulatory hub.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087036/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087036/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galagan, James E -- Minch, Kyle -- Peterson, Matthew -- Lyubetskaya, Anna -- Azizi, Elham -- Sweet, Linsday -- Gomes, Antonio -- Rustad, Tige -- Dolganov, Gregory -- Glotova, Irina -- Abeel, Thomas -- Mahwinney, Chris -- Kennedy, Adam D -- Allard, Rene -- Brabant, William -- Krueger, Andrew -- Jaini, Suma -- Honda, Brent -- Yu, Wen-Han -- Hickey, Mark J -- Zucker, Jeremy -- Garay, Christopher -- Weiner, Brian -- Sisk, Peter -- Stolte, Christian -- Winkler, Jessica K -- Van de Peer, Yves -- Iazzetti, Paul -- Camacho, Diogo -- Dreyfuss, Jonathan -- Liu, Yang -- Dorhoi, Anca -- Mollenkopf, Hans-Joachim -- Drogaris, Paul -- Lamontagne, Julie -- Zhou, Yiyong -- Piquenot, Julie -- Park, Sang Tae -- Raman, Sahadevan -- Kaufmann, Stefan H E -- Mohney, Robert P -- Chelsky, Daniel -- Moody, D Branch -- Sherman, David R -- Schoolnik, Gary K -- HHSN272200800059C/AI/NIAID NIH HHS/ -- HHSN272200800059C/PHS HHS/ -- R01 AI 071155/AI/NIAID NIH HHS/ -- R01 AI071155/AI/NIAID NIH HHS/ -- U19 AI 076217/AI/NIAID NIH HHS/ -- U19 AI076217/AI/NIAID NIH HHS/ -- England -- Nature. 2013 Jul 11;499(7457):178-83. doi: 10.1038/nature12337. Epub 2013 Jul 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, USA. jgalag@bu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23823726" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Anoxia/*genetics/metabolism ; Bacterial Proteins/genetics/metabolism ; Binding Sites ; Chromatin Immunoprecipitation ; Gene Expression Profiling ; *Gene Regulatory Networks/genetics ; Genomics ; Lipid Metabolism/genetics ; Metabolic Networks and Pathways/*genetics ; Models, Biological ; Mycobacterium tuberculosis/drug effects/*genetics/*metabolism/physiology ; Oxygen/pharmacology ; Proteolysis ; RNA, Messenger/genetics/metabolism ; Reproducibility of Results ; Sequence Analysis, DNA ; Transcription Factors/genetics/metabolism ; Tuberculosis/metabolism/microbiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...