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  • Animals  (357)
  • 1985-1989
  • 1975-1979  (357)
  • 1978  (357)
  • 1
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    Cellular analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Long-term habituation training in Aplysia californica produces a profound depression in the efficacy of synaptic transmission between mechanoreceptor neurons and gill motor neurons. This depression persists for more than 3 weeks. Thus a critical synaptic site for plasticity underlying long-term habituation is the same as that for short-term habituation. For this simple form of learning, short- and long-term memory share a common locus and aspects of a common mechanism: synaptic depression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Castellucci, V F -- Carew, T J -- Kandel, E R -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1306-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214854" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia ; Gills/physiology ; Habituation, Psychophysiologic/*physiology ; Mechanoreceptors/physiology ; Memory/*physiology ; Memory, Short-Term/physiology ; Motor Neurons/physiology ; *Reflex, Monosynaptic ; Retention (Psychology)/physiology ; Synaptic Membranes/physiology ; Synaptic Transmission ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Long-term treatment of rats with clinically effective tricyclic antidepressant drugs induced a selective increase in the inhibitory response of forebrain neurons to serotonin applied by microiontophoresis. Long-term administration of some related drugs which lack antidepressant efficacy failed to induce such a change. The enhanced response to serotonin induced by the clinically active tricyclic drugs took 1 to 2 weeks to develop, a time course which correlates with the delayed onset of therapeutic effects in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Montigny, C -- Aghajanian, G K -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725608" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Antidepressive Agents, Tricyclic/*pharmacology ; Decerebrate State ; Drug Synergism ; Geniculate Bodies/*drug effects ; Hippocampus/*drug effects ; Male ; Neural Inhibition/drug effects ; Norepinephrine/pharmacology ; Pyramidal Tracts/drug effects ; Rats ; Receptors, Serotonin/*drug effects ; Serotonin/*pharmacology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Nicotinamide adenine dinucleotide splitting enzyme: a characteristic of the mouse macrophage (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Murine macrophages are endowed with nicotinamide adenine dinucleotide splitting activity that is markedly higher than that of other cells, tissues, or organs of the mouse. This enzyme therefore can be used as a biochemical marker for distinguishing macrophages from other cells of the lymphoreticular system and from polymorphonuclear leukocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Artman, M -- Seeley, R J -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1293-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214853" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascitic Fluid/enzymology ; B-Lymphocytes/enzymology ; Blood Platelets/enzymology ; Bone Marrow/enzymology ; Humans ; Lymph Nodes/enzymology ; Macrophages/*enzymology ; Mice ; Monocytes/enzymology ; NAD+ Nucleosidase/*metabolism ; Neutrophils/enzymology ; Spleen/enzymology ; T-Lymphocytes/enzymology ; Tissue Distribution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Endoplasmic reticulum sequesters calcium in the squid giant axon (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Axons were loaded with calcium, rapidly frozen, and freeze-substituted. The endoplasmic reticulum, in addition to mitochondria, contained calcium deposits, as indicated by electron probe x-ray microanalysis. Oxalate injected into living axons helped to preserve calcium-containing deposits during preparation for microscopy. It is concluded that the endoplasmic reticulum is a calcium-sequestering compartment in the squid giant axon.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henkart, M P -- Reese, T S -- Brinley, F J Jr -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1300-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725607" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/*metabolism ; Calcium/*metabolism ; Decapodiformes ; Endoplasmic Reticulum/metabolism ; Intracellular Membranes/metabolism ; Mitochondria/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Shotgun collections of Charon 3A bacteriophages containing Eco RI fragments of human and mouse DNA were constructed with the use of in vitro packaging. Plaques were screened by hybridization, and globin-specific clones were isolated from both human (Charon 3AHs51.1) and mouse (Charon 3AMm30.5). The fragments cloned were detected in unfractionated genomic DNA by the Southern method of hybridization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blattner, F R -- Blechl, A E -- Denniston-Thompson, K -- Faber, H E -- Richards, J E -- Slightom, J L -- Tucker, P W -- Smithies, O -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1279-84.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725603" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Coliphages/genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Fetal Hemoglobin/genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; Poly A ; Poly T
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Cell lineage analysis by intracellular injection of a tracer enzyme (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Cell lineages during development of leeches can be ascertained by injection of horseradish peroxidase as a tracer into identified cells at early stages of embryogenesis. The injected embryos continue their normal development, in the course of which horseradish peroxidase is passed on in catalytically active form to the descendants of the injected cell. The distribution of the tracer enzyme and hence of the progeny of the injected cell can then be observed at a later stage of development by staining the preparation for horseradish peroxidase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weisblat, D A -- Sawyer, R T -- Stent, G S -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1295-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725606" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Horseradish Peroxidase ; Leeches/cytology/*embryology ; Methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Two globin-related clones isolated from collections of bacteriophages containing unfractionated Eco RI fragments of human and mouse DNA were characterized. Charon3AHs51.1Hbgamma includes 2.7 kilobase pairs of human DNA containing a large part of a fetal gamma globin chain structural gene; Charon 3AMm30.5 includes 4.7 kilobase pairs of mouse DNA related to alpha globin. The human fetal gamma globin gene has within its coding region two intervening sequences of noncoding DNA, IVS 1 and IVS 2, of approximately 1-0 and 900 base pairs. Sequence IVS 1 is located at the position of one of the two intervening sequences occurring in adult globin genes; IVS 2 is located at the position of the other.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smithies, O -- Blechl, A E -- Denniston-Thompson, K -- Newell, N -- Richards, J E -- Slightom, J L -- Tucker, P W -- Blattner, F R -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1284-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725604" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Codon ; DNA Restriction Enzymes/metabolism ; DNA, Recombinant ; Fetal Hemoglobin/*genetics ; *Genes ; Globins/*genetics ; Humans ; Methods ; Mice ; Nucleic Acid Hybridization ; RNA, Messenger/genetics
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Calcium entry leads to inactivation of calcium channel in Paramecium (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: Under depolarizing voltage clamp of Paramecium an inward calcium current developed and subsequently relaxed within 10 milliseconds. The relaxation was substantially slowed when most of the extracellular calcium was replaced by either strontium or barium. Evidence is presented that the relaxation is not accounted for by a drop in electromotive force acting on calcium, or by activation of a delayed potassium current. Relaxation of the current must, therefore, result from an inactivation of the calcium channel. This inactivation persisted after a pulse, as manifested by a reduced calcium current during subsequent depolarization. Inactivation was retarded by procedures that reduce net entry of calcium, and was independent of membrane potential. The calcium channel undergoes inactivation as a consequence of calcium entry during depolarization. In this respect, inactivation of the calcium channel departs qualitatively from the behavior described in the Hodgkin-Huxley model of the sodium channel.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brehm, P -- Eckert, R -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1203-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/103199" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Barium/pharmacology ; Calcium/*metabolism ; Egtazic Acid/pharmacology ; Electric Conductivity ; Ion Channels/drug effects/*metabolism ; Membrane Potentials ; Paramecium/*metabolism ; Strontium/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Transient synapses in the embryonic primate spinal cord (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: Electron microscopic and tritiated thymidine autoradiographic analysis of the embryonic spinal cord in the rhesus monkey reveals considerable rearrangement of cellular and synaptic relationships in the posterior (sensory) quadrant during early developmental stages. This remodeling involves the death of an entire population of neurons that received synapses from sensory afferent axons and the possible relocation of these afferents upon subsequently generated viable substantia gelatinosa neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Knyihar, E -- Csillik, B -- Rakic, P -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1206-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/103200" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Axons/ultrastructure ; Cell Survival ; Dendrites/ultrastructure ; Gestational Age ; Haplorhini ; Macaca mulatta ; Spinal Cord/*embryology/ultrastructure ; Synapses/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    6-Hydroxydopamine and anticholinergic drugs (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, S T -- Fibiger, H C -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Hydroxydopamines/*pharmacology ; Motor Activity/*drug effects ; Norepinephrine/pharmacology ; Parasympathomimetics/pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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