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  • Articles  (62,799)
  • Springer  (43,808)
  • BioMed Central  (14,828)
  • American Chemical Society  (4,163)
  • 2025-2025
  • 2010-2014  (62,799)
  • Medicine  (41,572)
  • Computer Science  (20,813)
  • Law  (3,170)
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  • Articles  (62,799)
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  • 1
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    Connexins: junctional and non-junctional modulators of proliferation (2014)
    Springer
    Details
    Publication Date: 2014-12-31
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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  • 2
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    Physical regulation of stem cells differentiation into teno-lineage: current strategies and future direction (2014)
    Springer
    Details
    Publication Date: 2014-12-31
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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  • 3
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    The Bucentaur (BCNT) protein family: a long-neglected class of essential proteins required for chromatin/chromosome organization and function (2014)
    Springer
    Details
    Publication Date: 2014-12-31
    Print ISSN: 0009-5915
    Electronic ISSN: 1432-0886
    Topics: Biology , Medicine
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  • 4
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    BitTorious: global controlled genomics data publication, research and archiving via BitTorrent extensions (2014)
    BioMed Central
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    Publication Date: 2014-12-31
    Description: Background: Centralized silos of genomic data are architecturally easier to initially design, develop and deploy than distributed models. However, as interoperability pains in EHR/EMR, HIE and other collaboration-centric life sciences domains have taught us, the core challenge of networking genomics systems is not in the construction of individual silos, but the interoperability of those deployments in a manner embracing the heterogeneous needs, terms and infrastructure of collaborating parties. This article demonstrates the adaptation of BitTorrent to private collaboration networks in an authenticated, authorized and encrypted manner while retaining the same characteristics of standard BitTorrent. Results: The BitTorious portal was sucessfully used to manage many concurrent domestic Bittorrent clients across the United States: exchanging genomics data payloads in excess of 500GiB using the uTorrent client software on Linux, OSX and Windows platforms. Individual nodes were sporadically interrupted to verify the resilience of the system to outages of a single client node as well as recovery of nodes resuming operation on intermittent Internet connections. Conclusions: The authorization-based extension of Bittorrent and accompanying BitTorious reference tracker and user management web portal provide a free, standards-based, general purpose and extensible data distribution system for large ‘omics collaborations.
    Electronic ISSN: 1471-2105
    Topics: Biology , Computer Science
    Published by BioMed Central
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  • 5
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    Connexins: junctional and non-junctional modulators of proliferation (2014)
    Springer
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    Publication Date: 2014-12-31
    Description: Mounting evidence indicates that dysregulation of gap junctions and their structural subunits—connexins—often occurs in, and sometimes causes, a variety of proliferative disorders, including cancer. Connexin-mediated regulation of cell proliferation is complex and may involve modulation of gap junction intercellular communication (GJIC), hemichannel signalling, or gap junction-independent paths. However, the exact mechanisms linking connexins to proliferation remain poorly defined and a number of contradictory studies report both pro- and anti-proliferative effects, effects that often depend on the cell or tissue type or the microenvironment. The present review covers junctional and non-junctional regulation of proliferation by connexins, with a particular emphasis on their association with cancer.
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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  • 6
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    Genotoxicity of Thermopsis turcica on Allium cepa L. roots revealed by alkaline comet and random amplified polymorphic DNA assays (2014)
    Springer
    Details
    Publication Date: 2014-12-31
    Description: This study was undertaken to evaluate genotoxic potential of Thermopsis turcica aqueous extracts on the roots of onion bulb ( Allium cepa L.) by comet assay and random amplified polymorphic DNA technique. The Allium root growth inhibition test indicated that the EC 50 and 2×EC 50 values were 8 and 16 mg/ml concentrations of T. turcica aqueous extracts, respectively. The negative control (distilled water), positive control (methyl methane sulfonate, 10 mg/l) and 8 and 16 mg/ml concentrations of T. turcica extracts were introduced to the roots of onion bulbs for 24 and 96 h. The root growth, DNA damage in root cells and randomly amplified polymorphic DNA (RAPD) profiles of root tissue were used as endpoints of the genotoxicity. The comet assay clearly indicated that dose-dependent single strand DNA breaks in the root nuclei of onions were determined for the treatment concentrations of T. turcica extracts. In comparison to RAPD profile of negative control group, RAPD polymorphisms became evident as disappearance and/or appearance of RAPD bands in treated roots. The diagnostic and phenetic numerical analyses of RAPD profiles obviously indicated dose-dependent genotoxicity induced by Thermopsis extracts. In conclusion, the results clearly indicated that water extract of T. turcica has genotoxic potential on the roots of onion bulbs as shown by comet assay and RAPD technique.
    Print ISSN: 0920-9069
    Electronic ISSN: 1573-0778
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer
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  • 7
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    Total and Monomethyl Mercury in Terrestrial Arthropods from the Central California Coast (2014)
    Springer
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    Publication Date: 2014-12-31
    Description: The aim of this project was to obtain a baseline understanding and investigate the concentration of mercury (Hg) in the tissue of terrestrial arthropods. The 4-month sampling campaign took place around Monterey Bay, California. Total mercury (HgT) concentrations (x ± SD, dry weight) for the captured specimens ranged from 22 to 188 ng g −1 in the Jerusalem crickets (Orthoptera: Stenopelmatidae); 65–233 ng g −1 in the camel crickets (Orthoptera: Rhaphidophoridae); 25–227 ng g −1 in the pill bugs (Isopoda: Armadillidiidae); 19–563 ng g −1 in the ground beetles (Coleoptera: Carabidae); 140–441 ng g −1 in the variegated meadowhawk dragonflies (Odonata: Libellulidae); 607–657 ng g −1 in the pacific spiketail dragonflies (Odonata: Cordulegastridae); and 81–1,249 ng g −1 in the wolf spiders (Araneae: Lycosidae). A subset of samples analyzed for monomethyl mercury (MMHg) suggest detrital pill bugs have a higher MMHg/HgT ratio than predatory ground beetles.
    Print ISSN: 0007-4861
    Electronic ISSN: 1432-0800
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Published by Springer
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  • 8
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    The Bucentaur (BCNT) protein family: a long-neglected class of essential proteins required for chromatin/chromosome organization and function (2014)
    Springer
    Details
    Publication Date: 2014-12-31
    Description: The evolutionarily conserved Bucentaur (BCNT) protein superfamily was identified about two decades ago in bovines, but its biological role has long remained largely unknown. Sparse studies in the literature suggest that BCNT proteins perform important functions during development. Only recently, a functional analysis of the Drosophila BCNT ortholog, called YETI, has provided evidence that it is essential for proper fly development and plays roles in chromatin organization. Here, we introduce the BCNT proteins and comprehensively review data that contribute to clarify their function and mechanistic clues on how they may control development in multicellular organisms.
    Print ISSN: 0009-5915
    Electronic ISSN: 1432-0886
    Topics: Biology , Medicine
    Published by Springer
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  • 9
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    Klf2 contributes to the stemness and self-renewal of human bone marrow stromal cells (2014)
    Springer
    Details
    Publication Date: 2014-12-31
    Description: Mesenchymal stem cells (MSCs) have shown great therapeutic potential in clinical trials; however, loss of pluripotency due to culture senescence is a major factor limiting their application. Understanding the physiology of stem cell self-renewal and stemness, and identifying the molecules that regulate these processes, are critical to future advances in tissue and organ regeneration. The Krüppel-like factor (Klf) family are key transcription factors implicated in self-renewal of embryonic stem cells. Here we identify Klf2 as a crucial transcription factor in undifferentiated human bone marrow stromal cells (hBMSCs), as indicated by gene expression in three culture media. To investigate the role of Klf2 in detail, an overexpression study using a lentiviral system in hBMSCs was performed. After Klf2 overexpression, cell proliferation was increased. The expression of pluripotency-associated genes, including Oct4, Nanog, and Rex1, was also upregulated by Klf2 overexpression. In addition, quantitative RT-PCR indicated a lower level of expression of differentiation related genes in Klf2 overexpressing cells as compared to control cells. Our results identify a functionally conserved role for Klf2 in hBMSCs, in which its expression is biologically important for stemness and self-renewal. These results are the first to show a role for Klf2 in the proliferation and pluripotency of hBMSCs.
    Print ISSN: 0920-9069
    Electronic ISSN: 1573-0778
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
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  • 10
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    HP1beta-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs (2014)
    BioMed Central
    Details
    Publication Date: 2014-12-31
    Description: Background: The repair of spontaneous and induced DNA lesions is a multistep process. Depending on the type of injury, damaged DNA is recognized by many proteins specifically involved in distinct DNA repair pathways. Results: We analyzed the DNA-damage response after ultraviolet A (UVA) and gamma irradiation of mouse embryonic fibroblasts and focused on upstream binding factor 1 (UBF1), a key protein in the regulation of ribosomal gene transcription. We found that UBF1, but not nucleolar proteins RPA194, TCOF, or fibrillarin, was recruited to UVA-irradiated chromatin concurrently with an increase in heterochromatin protein 1beta (HP1beta) level. Moreover, Forster Resonance Energy Transfer (FRET) confirmed that interaction between UBF1 and HP1beta was dependent on a functional chromo shadow domain of HP1beta. Thus, overexpression of HP1beta with a deleted chromo shadow domain had a dominant-negative effect on UBF1 recruitment to UVA-damaged chromatin. Transcription factor UBF1 also interacted directly with DNA inside the nucleolus but no interaction of UBF1 and DNA was confirmed outside the nucleolus, where UBF1 recruitment to DNA lesions appeared simultaneously with cyclobutane pyrimidine dimers; this occurrence was cell-cycle-independent. Conclusions: We propose that the simultaneous presence and interaction of UBF1 and HP1beta at DNA lesions is activated by the presence of cyclobutane pyrimidine dimers and mediated by the chromo shadow domain of HP1beta. This might have functional significance for nucleotide excision repair.
    Electronic ISSN: 1756-8935
    Topics: Biology , Medicine
    Published by BioMed Central
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