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  • Bücher  (6)
  • thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
  • RAND Corporation  (5)
  • Drug Discovery  (1)
  • 2020-2024  (6)
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  • Bücher  (6)
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  • 2020-2024  (6)
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  • 1
    Publikationsdatum: 2024-04-14
    Beschreibung: Liability effects on the economic performance of the pharmaceutical industry play a prominent role in the debate about the economic effects of product liability in the United States. The author analyzes incentive effects on company decisions, implications for economic outcomes such as drug safety and effectiveness, and suggests how public policy changes could mitigate liability-based sources of inefficient decisions of pharmaceutical companies.
    Schlagwort(e): Health Sciences ; Law ; thema EDItEUR::V Health, Relationships and Personal development::VS Self-help, personal development and practical advice::VSD Law, citizenship and rights for the lay person ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNB Private or civil law: general ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 2
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    RAND Corporation
    Publikationsdatum: 2024-04-01
    Beschreibung: The pharmaceutical industry can reconfigure its considerable resources to develop innovative and meaningful business models that are based on services that improve access and adherence to prescription drugs for common chronic conditions. Such innovation beyond drug development is consistent with the core capabilities of large pharmaceutical companies and has the potential to achieve profit levels similar to those of its traditional models.
    Schlagwort(e): Health Sciences ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2024-04-01
    Beschreibung: RAND researchers generated national estimates of consumption of four illicit drugs from 2000 to 2010: cocaine, heroin, marijuana, and methamphetamine. Throughout the decade, U.S. drug users spent on the order of $100 billion annually on these drugs, although the spending distribution and use patterns changed. For all of the drugs, total consumption and expenditures are driven by the minority of users who consume on 21 or more days each month.
    Schlagwort(e): Psychology ; Political Science ; Health Sciences ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKZ Therapy and therapeutics::MKZR Addiction and therapy ; thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFJ Coping with / advice about personal, social and health topics::VFJK Coping with / advice about drug and alcohol problems
    Sprache: Englisch
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  • 4
    Publikationsdatum: 2024-04-01
    Beschreibung: In January 2012, the U.S. White House Office of National Drug Control Policy (ONDCP) asked RAND to generate national estimates of the total number of users, total expenditures, and total consumption for four illicit drugs from 2000 to 2010: cocaine (including crack), heroin, marijuana, and methamphetamine. Drug users in the United States spend on the order of $100 billion annually on these drugs (in 2010 dollars). While this total figure has been stable over the decade, there have been important compositional shifts. From 2006 to 2010, the amount of marijuana consumed in the United States likely increased more than 30 percent, while the amount of cocaine consumed in the United States decreased by approximately 50 percent. These figures are consistent with supply-side indicators, such as seizures and production estimates. Methamphetamine consumption rose sharply from 2000 through the middle of the decade, and this was followed by a large decline through 2008. Heroin consumption remained fairly stable throughout the decade, although there is some evidence of an increase in the later years. For all of the drugs, total consumption and expenditures are driven by the minority of users who consume on 21 or more days each month.
    Schlagwort(e): Psychology ; Political Science ; Health Sciences ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKZ Therapy and therapeutics::MKZR Addiction and therapy ; thema EDItEUR::V Health, Relationships and Personal development::VF Family and health::VFJ Coping with / advice about personal, social and health topics::VFJK Coping with / advice about drug and alcohol problems
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2024-04-01
    Beschreibung: In this study we interrogate 630 compounds of the Maybridge Rule of 3 Fragment Library for compounds that interact with, and inhibit TbCK. The Maybridge Rule of 3 Fragment Library is a small collection of quantifiable diverse, pharmacophoric rich, chemical entities that comply with the following criteria; MW ≤ 300, cLogP ≤ 3, H-Bond Acceptors ≤ 3, H-Bond Donors ≤ 3, Rotatable bonds (Flexibility Index) ≤ 3, Polar Surface Area ≤ 60 Å2 and aqueous solubility ≥ 1 mM using LogS and high purity (≥ 95%). Comparisons between two different screening methods, a coupled enzyme activity assay and differential scanning fluorimetry, has allowed identification of compounds that interact and inhibit the T. brucei choline kinase, several of which possess selective trypanocidal activity. Screening of a comparatively small fragment library by two different screening methods has allowed identification of several compounds that interact with and inhibit TbCK, a genetically validated drug target against African sleeping sickness. Some of the inhibitory fragments were also selectively trypanocidal, considering these are relatively simple molecules with no optimization, finding low μΜ inhibitors is very encouraging. Moreover some of the morphological phenotypes of these trypanocidal compounds include cell-cycle arrests similar to those observed for the TbCK conditional knockout grown under permissive conditions.
    Schlagwort(e): pharmacology ; toxicology ; pharmacology ; toxicology ; Assay ; Enzyme ; Molar concentration ; Protein ; Thermal shift assay ; Trypanosoma brucei ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
    Format: image/jpeg
    Format: image/jpeg
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  • 6
    Publikationsdatum: 2024-04-01
    Beschreibung: Marijuana legalization is a controversial and multifaceted issue that is now the subject of serious debate. In May 2014, Vermont Governor Peter Shumlin signed a bill requiring the Secretary of Administration to produce a report about various consequences of legalizing marijuana. This resulting report provides a foundation for thinking about the various consequences of different policy options while being explicit about the uncertainties involved.
    Schlagwort(e): Health Sciences ; Political Science ; Psychology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPQ Central / national / federal government::JPQB Central / national / federal government policies ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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