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  • Rats  (97)
  • American Association for the Advancement of Science (AAAS)  (97)
  • 2020-2024
  • 1975-1979  (97)
  • 1978  (97)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (97)
  • Springer  (1)
Years
  • 2020-2024
  • 1975-1979  (97)
Year
  • 1
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    Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Long-term treatment of rats with clinically effective tricyclic antidepressant drugs induced a selective increase in the inhibitory response of forebrain neurons to serotonin applied by microiontophoresis. Long-term administration of some related drugs which lack antidepressant efficacy failed to induce such a change. The enhanced response to serotonin induced by the clinically active tricyclic drugs took 1 to 2 weeks to develop, a time course which correlates with the delayed onset of therapeutic effects in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Montigny, C -- Aghajanian, G K -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725608" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Antidepressive Agents, Tricyclic/*pharmacology ; Decerebrate State ; Drug Synergism ; Geniculate Bodies/*drug effects ; Hippocampus/*drug effects ; Male ; Neural Inhibition/drug effects ; Norepinephrine/pharmacology ; Pyramidal Tracts/drug effects ; Rats ; Receptors, Serotonin/*drug effects ; Serotonin/*pharmacology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    6-Hydroxydopamine and anticholinergic drugs (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, S T -- Fibiger, H C -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Hydroxydopamines/*pharmacology ; Motor Activity/*drug effects ; Norepinephrine/pharmacology ; Parasympathomimetics/pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Intraventricular alloxan eliminates feeding elicited by 2-deoxyglucose (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: Evidence suggests that alloxan reacts with membrane-bound glucoreceptors and that it competes with glucose molecules for these sites. We therefore administered small quantities of alloxan into the cerebrospinal fluid of rats to determine what effect this might have on their ability to react to changes of glucose concentration. Rats treated in this manner did not eat as much as controls in response to the intraperitoneal administration of 2-deoxyglucose or to a 24-hour fast, and they became hypoglycemic significantly sooner than controls when fasted. The data suggest that the function of brain glucoreceptors is to protect the body from sudden decreases of glucose and that these glucoreceptors play little if any role in the normal regulation or maintenance of feeding, body weight, or blood glucose concentrations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woods, S C -- McKay, L D -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1209-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725595" target="_blank"〉PubMed〈/a〉
    Keywords: Alloxan/administration & dosage/*pharmacology ; Animals ; Deoxyglucose/antagonists & inhibitors/pharmacology ; Eating/*drug effects ; Female ; Glucose ; Injections, Intraventricular ; Rats ; Receptors, Drug/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Subsynaptic plate perforations: changes with age and experience in the rat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: The relative frequency of appearance of discontinuities in the postsynaptic thickening, or perforations in the subsynaptic plate, increased with age and experience. Rats reared from weaning in complex or social environments had a significantly higher proportion of occipital cortical synapses with perforations than did rats reared in isolation. In addition, the relative frequency of these perforations more than tripled between 10 and 60 days of age. Shifts in the frequency of perforations can occur independently of changes in the size of synpases. This result suggests a new potential mechanism of synaptic plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenough, W T -- West, R W -- DeVoogd, T J -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1096-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715459" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cerebral Cortex/ultrastructure ; Environment ; Male ; Occipital Lobe/*ultrastructure ; Rats ; Synapses/ultrastructure ; Synaptic Membranes/*ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Hippocampal aging and adrenocorticoids: quantitative correlations (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: Altered neural-endocrine relations have been proposed as factors in mammalian aging. In the same rats from three age groups we quantified astrocyte reactivity in hippocampus, performed radioimmunoassays for plasma adrenocorticoids, and measured adrenal weight. These variables were correlated in individual animals and generally increased with age. The findings are consistent with recent hypotheses that endocrine levels are related to brain aging, either as cause or effect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landfield, P W -- Waymire, J C -- Lynch, G -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1098-102.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715460" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/*anatomy & histology ; *Aging ; Animals ; Astrocytes/cytology ; Corticosterone/*blood ; Hippocampus/*cytology ; Male ; Neuroglia/cytology ; Organ Size ; Rats ; Rats, Inbred F344
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Angiotensin regulates release and synthesis of serotonin in brain (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: Angiotensin II released serotonin from neuron terminals and accelerated synthesis of the serotonin. This increase in synthesis depended on the activation of tryptophan hydroxylase. A biphasic effect was observed: at high doses the stimulatory effect depended on conversion of angiotensin II to angiotensin III. At low doses an inhibitory effect was found, possible dependent on an angiotensin II metabolite. These actions represent a subtle regulation of the open-loop serotonin system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nahmod, V E -- Finkielman, S -- Benarroch, E E -- Pirola, C J -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1091-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/152460" target="_blank"〉PubMed〈/a〉
    Keywords: Angiotensin II/*analogs & derivatives/*pharmacology ; Angiotensin III/*pharmacology ; Animals ; Blood Pressure/drug effects ; Brain Stem/metabolism ; Enzyme Activation/drug effects ; Fenclonine/pharmacology ; Hypothalamus/metabolism ; Morphine/pharmacology ; Rats ; Receptors, Serotonin/drug effects ; Serotonin/*metabolism/pharmacology ; Tryptophan Hydroxylase/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: The use of different receptor blocking agents and single-unit recording techniques indicates that feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants is mediated by presynaptic alpha-receptors. After chronic imipramine treatment, noradrenaline neurons in the locus coeruleus of rat brain remained partly depressed, in agreement with clinical data. They were, however, resistant to further inhibition by imipramine or clonidine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Svensson, T H -- Usdin, T -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/213833" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/drug effects ; Animals ; Antidepressive Agents, Tricyclic/*pharmacology ; Feedback ; Locus Coeruleus/*drug effects ; Male ; Norepinephrine ; Rats ; Receptors, Adrenergic/*drug effects ; Receptors, Adrenergic, alpha/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Long ascending projections from substantia gelatinosa Rolandi and the subjacent dorsal horn in the rat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: Small neurons of the substantia gelatinosa Rolandi and the subjacent dorsal horn of the spinal cord have been thought to exert a direct modulatory effect only on neurons located within a distance of a few spinal segemnts. By using the technique of retorograde transport of horseradish peroxidase, however, it has been found that in the rat a significant number of these cells, particularly those of the subjacent dorsal horn, ascend many spinal segments to the lateral cervical nucleus and to the lower brainstem. These data provide an anatomic basis for a role of substantia gelatinosa Rolandi and subjacent dorsal horn cells in madulating or contributing to sensory information transmission not only in nearby segments but in far distant structures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giesler, G J Jr -- Cannon, J T -- Urca, G -- Liebeskind, J C -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):984-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715454" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/cytology ; Animals ; Brain Stem/*cytology ; Male ; Rats ; Spinal Cord/*cytology/physiology ; Substantia Gelatinosa/cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa) (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Margules, D L -- Moisset, B -- Lewis, M J -- Shibuya, H -- Pert, C B -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):988-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Eating/drug effects ; Endorphins/antagonists & inhibitors/blood/*physiology ; Feeding Behavior/*physiology ; Female ; Male ; Mice ; Mice, Obese/*physiology ; Naloxone/pharmacology ; Obesity/genetics/*physiopathology ; Pituitary Gland/physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Light stimulates tyrosine hydroxylase activity and dopamine synthesis in retinal amacrine neurons (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-24
    Description: Retinal dopamine-containing amacrine neurons are rapidly activated by light, as shown by an increase in the rate of dopamine formation in vivo and a concomitant increase in the activity of tyrosine hydroxylase, measured in vitro with a subsaturating concentration of pteridine cofactor. Activation of tyrosine hydroxylase also occurs when isolated eyes from rats killed in the dark are exposed to a strobe light. Studies of amacrine neurons should provide basic data about the biochemical processing of visual information, as well as the physiological presynaptic regulatory mechanisms of dopamine-containing neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iuvone, P M -- Galli, C L -- Garrison-Gund, C K -- Neff, N H -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):901-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/30997" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Circadian Rhythm ; Dopamine/*biosynthesis ; Enzyme Activation/radiation effects ; Kinetics ; *Light ; Male ; Neurons/metabolism ; Rats ; Retina/cytology/enzymology/*metabolism ; Tyrosine 3-Monooxygenase/*biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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