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  • Male  (137)
  • American Association for the Advancement of Science (AAAS)  (137)
  • Elsevier
  • 2020-2024
  • 1975-1979  (137)
  • 1978  (137)
  • 1977
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (137)
  • Elsevier
  • Springer  (1)
Years
  • 2020-2024
  • 1975-1979  (137)
Year
  • 1978  (137)
  • 1977
  • 1979  (104)
  • 1
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    Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Long-term treatment of rats with clinically effective tricyclic antidepressant drugs induced a selective increase in the inhibitory response of forebrain neurons to serotonin applied by microiontophoresis. Long-term administration of some related drugs which lack antidepressant efficacy failed to induce such a change. The enhanced response to serotonin induced by the clinically active tricyclic drugs took 1 to 2 weeks to develop, a time course which correlates with the delayed onset of therapeutic effects in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Montigny, C -- Aghajanian, G K -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725608" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Antidepressive Agents, Tricyclic/*pharmacology ; Decerebrate State ; Drug Synergism ; Geniculate Bodies/*drug effects ; Hippocampus/*drug effects ; Male ; Neural Inhibition/drug effects ; Norepinephrine/pharmacology ; Pyramidal Tracts/drug effects ; Rats ; Receptors, Serotonin/*drug effects ; Serotonin/*pharmacology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Exponential decrease during aging and random lifetime of mouse spermatogonial stem cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: Variation in the number of spermatogonial stem cells during the lifespan of the mouse was examined by assaying the number of clonogenic cells, that is, spermatogenic stem cells, surviving known doses of radiation. The results indicated that the stem cell number decreased exponentially with age.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suzuki, N -- Withers, H R -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1214-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725597" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Dose-Response Relationship, Radiation ; Gamma Rays ; Male ; Mice ; Spermatogonia/*cytology ; Spermatozoa/*cytology ; Testis/*cytology/radiation effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Subsynaptic plate perforations: changes with age and experience in the rat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: The relative frequency of appearance of discontinuities in the postsynaptic thickening, or perforations in the subsynaptic plate, increased with age and experience. Rats reared from weaning in complex or social environments had a significantly higher proportion of occipital cortical synapses with perforations than did rats reared in isolation. In addition, the relative frequency of these perforations more than tripled between 10 and 60 days of age. Shifts in the frequency of perforations can occur independently of changes in the size of synpases. This result suggests a new potential mechanism of synaptic plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenough, W T -- West, R W -- DeVoogd, T J -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1096-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715459" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cerebral Cortex/ultrastructure ; Environment ; Male ; Occipital Lobe/*ultrastructure ; Rats ; Synapses/ultrastructure ; Synaptic Membranes/*ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Kainic acid injections result in degeneration of cochlear nucleus cells innervated by the auditory nerve (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: When kainic acid, a putative neurotoxin for neurons with glutamatergic input, is injected into the brainstem, it produces a selective pattern of degeneration in the cochlear nucleus. The rate and extent of degeneration is correlated with the distribution of the primary auditory fibers. This evidence supports the hypothesis that glutamate is the neurotransmitter for primary auditory fibers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bird, S J -- Gulley, R L -- Wenthold, R J -- Fex, J -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1087-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/31000" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain Stem/*drug effects ; Dose-Response Relationship, Drug ; Glutamates/physiology ; Guinea Pigs ; Kainic Acid/*pharmacology ; Male ; Nerve Degeneration/drug effects ; Neurotransmitter Agents/physiology ; Pyrrolidines/*pharmacology ; Receptors, Neurotransmitter/*drug effects ; Vestibulocochlear Nerve/*drug effects/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Hippocampal aging and adrenocorticoids: quantitative correlations (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: Altered neural-endocrine relations have been proposed as factors in mammalian aging. In the same rats from three age groups we quantified astrocyte reactivity in hippocampus, performed radioimmunoassays for plasma adrenocorticoids, and measured adrenal weight. These variables were correlated in individual animals and generally increased with age. The findings are consistent with recent hypotheses that endocrine levels are related to brain aging, either as cause or effect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landfield, P W -- Waymire, J C -- Lynch, G -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1098-102.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715460" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenal Glands/*anatomy & histology ; *Aging ; Animals ; Astrocytes/cytology ; Corticosterone/*blood ; Hippocampus/*cytology ; Male ; Neuroglia/cytology ; Organ Size ; Rats ; Rats, Inbred F344
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: The use of different receptor blocking agents and single-unit recording techniques indicates that feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants is mediated by presynaptic alpha-receptors. After chronic imipramine treatment, noradrenaline neurons in the locus coeruleus of rat brain remained partly depressed, in agreement with clinical data. They were, however, resistant to further inhibition by imipramine or clonidine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Svensson, T H -- Usdin, T -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1089-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/213833" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/drug effects ; Animals ; Antidepressive Agents, Tricyclic/*pharmacology ; Feedback ; Locus Coeruleus/*drug effects ; Male ; Norepinephrine ; Rats ; Receptors, Adrenergic/*drug effects ; Receptors, Adrenergic, alpha/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Long ascending projections from substantia gelatinosa Rolandi and the subjacent dorsal horn in the rat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: Small neurons of the substantia gelatinosa Rolandi and the subjacent dorsal horn of the spinal cord have been thought to exert a direct modulatory effect only on neurons located within a distance of a few spinal segemnts. By using the technique of retorograde transport of horseradish peroxidase, however, it has been found that in the rat a significant number of these cells, particularly those of the subjacent dorsal horn, ascend many spinal segments to the lateral cervical nucleus and to the lower brainstem. These data provide an anatomic basis for a role of substantia gelatinosa Rolandi and subjacent dorsal horn cells in madulating or contributing to sensory information transmission not only in nearby segments but in far distant structures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Giesler, G J Jr -- Cannon, J T -- Urca, G -- Liebeskind, J C -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):984-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715454" target="_blank"〉PubMed〈/a〉
    Keywords: Afferent Pathways/cytology ; Animals ; Brain Stem/*cytology ; Male ; Rats ; Spinal Cord/*cytology/physiology ; Substantia Gelatinosa/cytology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Child spacing and birth order: effect on intellectual ability in two-child families (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: The effect on intellectual ability of the spacing of the birth of siblings was studied in two series of young men from two-child families: (i) 535 pairs of brothers and (ii) 1511 unrelated firstborn and secondborn. Birth-order effect and level of ability were not influenced by length of interval between firstborn and secondborn.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Belmont, L -- Stein, Z -- Zybert, P -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):995-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/568823" target="_blank"〉PubMed〈/a〉
    Keywords: *Birth Order ; Family ; Female ; Humans ; *Intelligence ; Male ; Maternal Age ; Socioeconomic Factors ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    beta-Endorphin is associated with overeating in genetically obese mice (ob/ob) and rats (fa/fa) (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: Small doses of the opiate antagonist naloxone selectively abolished overeating in genetically obese mice (ob/ob) and rats (fa/fa). Elevated concentrations of the naturally occurring opiate beta-endorphin were found in the pituitaries of both obese species and in the blood plasma of the obese rats. Brain levels of beta-endorphin and Leu-enkephalin were unchanged. These data suggest that excess pituitary beta-endorphin may play a role in the development of the overeating and obesity syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Margules, D L -- Moisset, B -- Lewis, M J -- Shibuya, H -- Pert, C B -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):988-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715455" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Disease Models, Animal ; Eating/drug effects ; Endorphins/antagonists & inhibitors/blood/*physiology ; Feeding Behavior/*physiology ; Female ; Male ; Mice ; Mice, Obese/*physiology ; Naloxone/pharmacology ; Obesity/genetics/*physiopathology ; Pituitary Gland/physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Light stimulates tyrosine hydroxylase activity and dopamine synthesis in retinal amacrine neurons (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-24
    Description: Retinal dopamine-containing amacrine neurons are rapidly activated by light, as shown by an increase in the rate of dopamine formation in vivo and a concomitant increase in the activity of tyrosine hydroxylase, measured in vitro with a subsaturating concentration of pteridine cofactor. Activation of tyrosine hydroxylase also occurs when isolated eyes from rats killed in the dark are exposed to a strobe light. Studies of amacrine neurons should provide basic data about the biochemical processing of visual information, as well as the physiological presynaptic regulatory mechanisms of dopamine-containing neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iuvone, P M -- Galli, C L -- Garrison-Gund, C K -- Neff, N H -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):901-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/30997" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Circadian Rhythm ; Dopamine/*biosynthesis ; Enzyme Activation/radiation effects ; Kinetics ; *Light ; Male ; Neurons/metabolism ; Rats ; Retina/cytology/enzymology/*metabolism ; Tyrosine 3-Monooxygenase/*biosynthesis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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