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  • American Chemical Society  (23,108)
  • American Association for the Advancement of Science (AAAS)  (2,126)
  • Cambridge University Press  (1,996)
  • 1980-1984  (27,230)
  • 1983  (27,230)
Collection
Keywords
Publisher
Years
  • 1980-1984  (27,230)
Year
  • 11
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    The thymus-adrenal connection: thymosin has corticotropin-releasing activity in primates (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: Endotoxin-free thymosin fraction 5 elevated corticotropin, beta-endorphin, and cortisol in a dose- and time-dependent fashion when administered intravenously to prepubertal cynomolgus monkeys. Two synthetic component peptides of thymosin fraction 5 had no acute effects on pituitary function, suggesting that some other peptides in thymosin fraction 5 were responsible for its corticotropin-releasing activity. In agreement with these observations, total thymectomy of juvenile macaques was associated with decreases in plasma cortisol, corticotropin, and beta-endorphin. These findings indicate that the prepubertal primate thymus contains corticotropin-releasing activity that may contribute to a physiological immunoregulatory circuit between the developing immunological and pituitary-adrenal systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Healy, D L -- Hodgen, G D -- Schulte, H M -- Chrousos, G P -- Loriaux, D L -- Hall, N R -- Goldstein, A L -- CA 24974/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1353-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318312" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/*blood ; Animals ; Dose-Response Relationship, Drug ; Endorphins/blood ; Female ; Hydrocortisone/blood ; Kinetics ; Macaca fascicularis ; Thymectomy ; Thymosin/analogs & derivatives/*pharmacology ; Thymus Gland/*physiology ; beta-Endorphin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    Molecular Basis of Herbicide Resistance in Amaranthus hybridus (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: Resistance of different species of weeds to s-triazines, a commonly used class of herbicides, has been shown to involve a change in the binding affinity of the herbicide to a chloroplast polypeptide of 32,000 daltons. A single amino acid difference in this 32,000-dalton protein appears to be responsible for resistance to the herbicide in Amaranthus hybridus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hirschberg, J -- McIntosh, L -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1346-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773338" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Estradiol fatty acid esters occur naturally in human blood (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: Treatment of nonpolar ether extracts of human female blood with mild alkali produced more immunoassayable estradiol than the unhydrolyzed extract. Analysis of the serum extracts showed that the substance which released immunoreactive estradiol after hydrolysis has chromatographic properties identical to those of fatty acid esters of estradiol esterified at carbon 17. The physiological role of these previously unknown endogenous esters might be inferred from their structural similarity to synthetic drugs used therapeutically for their prolonged estrogenic action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janocko, L -- Hochberg, R B -- CA29591/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1334-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6419346" target="_blank"〉PubMed〈/a〉
    Keywords: Chromatography, High Pressure Liquid ; Esters ; Estradiol/*analogs & derivatives/blood ; Fatty Acids ; Female ; Humans ; Hydrogen-Ion Concentration ; Hydrolysis ; Male ; Menotropins/pharmacology ; Menstruation ; Radioimmunoassay
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Nuclear winter: global consequences of multple nuclear explosions (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: The potential global atmospheric and climatic consequences of nuclear war are investigated using models previously developed to study the effects of volcanic eruptions. Although the results are necessarily imprecise due to wide range of possible scenaros and uncertainty in physical parameters, the most probable first-order effects are serious. Significant hemispherical attenuation of the solar radiation flux and subfreezing land temperatures may be caused by fine dust raised in high-yield nuclear surface bursts and by smoke from city and forest fires ignited by airbursts of all yields. For many simulated exchanges of several thousand megatons, in which dust and smoke are generated and encircle the earth within 1 to 2 weeks, average light levels can be reduced to a few percent of ambient and land temperatures can reach -15 degrees to -25 degrees C. The yield threshold for major optical and climatic consequences may be very low: only about 100 megatons detonated over major urban centers can create average hemispheric smoke optical depths greater than 2 for weeks and, even in summer, subfreezing land temperatures for months. In a 5000-megaton war, at northern mid-latitude sites remote from targets, radioactive fallout on time scales of days to weeks can lead to chronic mean doses of up to 50 rads from external whole-body gamma-ray exposure, with a likely equal or greater internal dose from biologically active radionuclides. Large horizontal and vertical temperature gradients caused by absorption of sunlight in smoke and dust clouds may greatly accelerate transport of particles and radioactivity from the Northern Hemisphere to the Southern Hemisphere. When combined with the prompt destruction from nuclear blast, fires, and fallout and the later enhancement of solar ultraviolet radiation due to ozone depletion, long-term exposure to cold, dark, and radioactivity could pose a serious threat to human survivors and to other species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Turco, R P -- Toon, O B -- Ackerman, T P -- Pollack, J B -- Sagan, C -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1283-92.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773320" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    An approach to epidemiology: the population dynamics of infectious diseases (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Woodruff, D S -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1321-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773331" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    How a nerve fiber repairs its cut end: involvement of phospholipase A2 (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: Following transection of a giant axon, the nerve membrane at the cut end is resealed within 5 to 30 minutes. This membrane resealing process is highly dependent upon temperature and extracellular calcium ions. The membrane resealing is triggered by excess calcium entering the axoplasm at the site of transection but is prevented by the application of phospholipase A2 inhibitors. We propose that calcium activated phospholipase A2 plays a central role in resealing of the ruptured nerve membrane.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yawo, H -- Kuno, M -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1351-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6658457" target="_blank"〉PubMed〈/a〉
    Keywords: Acetophenones/pharmacology ; Animals ; Axons/enzymology/*physiology/ultrastructure ; Calcium/pharmacology ; Cell Membrane/physiology ; Denervation ; Enzyme Activation ; Membrane Potentials ; Periplaneta ; Phospholipases/*metabolism ; Phospholipases A/*metabolism ; Phospholipases A2 ; Quinacrine/pharmacology ; Temperature
    Print ISSN: 0036-8075
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  • 17
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    A long-lived family (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rudkin, G T -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1280.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773317" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Biotinated probe containing a long-terminal repeat hybridized to a mouse colon tumor and normal tissue (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: The cloned complementary DNA pMCT-1, which contains an intracisternal A particle long-terminal repeat, is more highly expressed in a mouse colon tumor than in the normal mouse colon. In situ hybridization of biotin-substituted pMCT-1 to fixed frozen sections shows that expression of pMCT-1 is seen throughout the tumor and is highly heterogeneous on a cellular basis, while expression is undetectable in any cell in the normal colonic mucosa.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Royston, M E -- Augenlicht, L H -- CA 22367/CA/NCI NIH HHS/ -- CA 33383/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6689218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biotin ; Colon/*analysis ; Colonic Neoplasms/*genetics/pathology ; Dna ; Interphase ; Intestinal Mucosa/analysis ; Male ; Mice ; Mice, Inbred BALB C ; *Nucleic Acid Hybridization ; RNA, Neoplasm/*genetics ; Repetitive Sequences, Nucleic Acid ; *Transcription, Genetic
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Membrane lipid from deep-sea hydrothermal vent methanogen: a new macrocyclic glycerol diether (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: The membrane lipid of a new deep-sea hydrothermal vent methanogen, Methanococcus jannaschii, has been structurally characterized. The hydrolyzed polar lipid of this archaebacterium is primarily (95 percent) a macrocyclic glycerol diether, which has not been described previously. The structure was elucidated by a combination of chemical and spectroscopic techniques. An initial survey of selected methanogens failed to indicate the presence of this membrane lipid in any microorganism other than Methanococcus jannaschii.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Comita, P B -- Gagosian, R B -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1329-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773336" target="_blank"〉PubMed〈/a〉
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  • 20
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    Hominoid phylogeny: new interpretations of ape and human ancestry (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-12-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Delson, E -- New York, N.Y. -- Science. 1983 Dec 23;222(4630):1320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17773330" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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