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  • 1
    Publikationsdatum: 2022-11-04
    Beschreibung: Recalling IOC-Resolution XXX-3 and in accordance with 207 EX/Dec.5.II.A, this report provides a summary of a recently completed evaluation, namely: Internal Oversight Service (IOS) Evaluation of the Strategic positioning of the Intergovernmental Oceanographic Commission (IOC-UNESCO).
    Beschreibung: Item 9 of the provisional agenda of the Executive Board of UNESCO (212 EX/9). OPENASFA INPUT
    Beschreibung: Published
    Beschreibung: Non Refereed
    Schlagwort(e): International Oceanographic Commission of UNESCO ; Strategic position ; IOC-UNESCO ; Evaluation ; Scientific programmes ; Oceanography
    Repository-Name: AquaDocs
    Materialart: Report
    Format: 9pp.
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Publikationsdatum: 2022-11-02
    Beschreibung: Among the approximately 10,000 beneficial species of marine phytoplankton in the world’s oceans today, some 200 taxa can harm human society through the production of toxins that threaten seafood security and human health. These toxins are also responsible for wild or aquaculture fish-kills, may interfere with recreation-al use of coastal or inland waters, or cause economic losses. Non-toxic microalgae attaining high biomass can also cause Harmful Algal Blooms (HABs) by producing seawater discolorations, anoxia or mucilage that negatively affect the environment and human activities. The most frequently asked questions about harmful algal blooms are if they are increasing and expand-ing worldwide, and what are the mechanisms behind this perceived escalation. These questions have been addressed in several review papers concerning HAB trends at various scales, where evidences of expansion, intensification and increased impacts of harmful algal blooms have been gathered from a selection of examples that have gained high prominence in the scientific world and in society 1,2,3,4. Eutrophication, human-mediated introduction of alien harmful species, climatic variability, and aquaculture have all been mentioned as possible causes of HAB trends at various spatial and temporal scales 5,6. Over the last 40 years, the capacity and monitoring efforts to detect harmful species and harmful events have significantly increased, thus increasing the reporting of harmful events across the world’s seas. The resulting information is mostly scattered in the ever growing literature, with data from statutory monitoring programs often not published in peer review journals, while an extensive and detailed overview of the huge amount of information on harmful species, their spatial and temporal distribution and the trends of HABs they have caused has never been attempted so far. This lack of a synthesis of the relevant data has hampered a sound global assessment of the present status of phenomena related to harmful algae. Following the lead of the International Panel for Climate Change (IPCC) consensus reporting mechanism, and to complement the World Ocean Assessment, the need has been expressed for a Global HAB Status Report compiling an overview of Harmful Algal Bloom events and their societal impacts; providing a worldwide appraisal of the occurrence of toxin-producing microalgae; aimed towards the long term goal of assessing the status and probability of change in HAB frequencies, intensities, and range resulting from environmental changes at the local and global scale. This initiative was launched in April 2013 in Paris by the IOC Intergovernmental Panel on HABs (IOC/IPHAB), and has been pursued with the support of the Government of Flanders and hosted within the IOC International Oceanographic Date Exchange Programme (IODE) in partnership with ICES, PICES and IAEA. As a first step towards a global HAB status assessment, a Special Issue of the journal Harmful Algae (vol. 102, February 2021) has been published comprising 12 papers 7-18 each presenting an overview of toxic and non-toxic HABs in a specific area of the world’s seas. The regional overviews build on existing literature and exploit the information gathered in two relevant data-bases, both incorporated into the Ocean Biodiversity Information System (OBIS).
    Beschreibung: Government of Flanders
    Beschreibung: OPENASFA INPUT This Global HAB Status Report summary was prepared based on the special issue Global HAB Status reporting, vol. 102 (Feb. 2021) of the Harmful Algae (Elsevier Journal)
    Beschreibung: Published
    Beschreibung: Refereed
    Schlagwort(e): Harmful Algae Bloom ; Status Report ; HAB ; IODE ; International Oceanographic Data and Information Exchange ; Ocean Biodiversity Information System ; OBIS ; Harmful species ; PICES ; ICES ; IAEA
    Repository-Name: AquaDocs
    Materialart: Report
    Format: 14pp.
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    facet.materialart.
    Unbekannt
    UNESCO | Paris, France
    Publikationsdatum: 2022-09-30
    Beschreibung: In 2017, the UN General Assembly declared the UN Decade of Ocean Science for Sustainable Development (2021-2030). It has entrusted IOC-UNESCO with the design and delivery of the Decade to ensure that ocean science is indeed underpinning sustainable ocean management and the 2030 Sustainable Development Agenda more broadly. Fulfilling its mandate as trustee of the Ocean Decade, as well as delivering on a growing list of additional roles, in an oceanographic space that is both expanding and increasingly crowded, establishes an important opportunity but also an overarching challenge for IOC-UNESCO. In the context of the upcoming UN Decade of the Ocean, the IOC-UNESCO agreed with the Internal Oversight Service (IOS) on the merit of conducting an evaluation of its strategic positioning within the UN system and the broader landscape of ocean-related actors and programmes, taking into account relevant enabling policy frameworks to which the work of the Commission responds.
    Beschreibung: OPENASFA INPUT Published by UNESCO's Internal Oversight Service.
    Beschreibung: Published
    Beschreibung: Not Known
    Schlagwort(e): Evaluation ; International Oceanographic Commission of UNESCO ; Oceanography ; Scientific programmes
    Repository-Name: AquaDocs
    Materialart: Report
    Format: 2pp.
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    facet.materialart.
    Unbekannt
    UNESCO | Paris, France
    Publikationsdatum: 2022-09-30
    Beschreibung: Environmental DNA expeditions in UNESCO World Heritage Marine Sites: engaging citizen-scientists for biodiversity conservation of UNESCO sites.
    Beschreibung: Government of Flanders
    Beschreibung: OPENASFA INPUT
    Beschreibung: Published
    Schlagwort(e): Biodiversity ; Environmental DNA ; eDNA ; Marine environment ; Water analysis ; Oceanographic data ; OBIS ; Open Science ; Community participation ; Research projects ; World Heritage List
    Repository-Name: AquaDocs
    Materialart: Other
    Format: 2pp.
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2022-06-17
    Beschreibung: Sea wave monitoring is key in many applications in oceanography such as the validation of weather and wave models. Conventional in situ solutions are based on moored buoys whose measurements are often recognized as a standard. However, being exposed to a harsh environment, they are not reliable, need frequent maintenance, and the datasets feature many gaps. To overcome the previous limitations, we propose a system including a buoy, a micro-seismic measuring station, and a machine learning algorithm. The working principle is based on measuring the micro-seismic signals generated by the sea waves. Thus, the machine learning algorithm will be trained to reconstruct the missing buoy data from the micro-seismic data. As the micro-seismic station can be installed indoor, it assures high reliability while the machine learning algorithm provides accurate reconstruction of the missing buoy data. In this work, we present the methods to process the data, develop and train the machine learning algorithm, and assess the reconstruction accuracy. As a case of study, we used experimental data collected in 2014 from the Northern Tyrrhenian Sea demonstrating that the data reconstruction can be done both for significant wave height and wave period. The proposed approach was inspired from Data Science, whose methods were the foundation for the new solutions presented in this work. For example, estimating the period of the sea waves, often not discussed in previous works, was relatively simple with machine learning. In conclusion, the experimental results demonstrated that the new system can overcome the reliability issues of the buoy keeping the same accuracy.
    Beschreibung: Assist in Gravitation and Instrumentation srl Istituto Nazionale di Geofisica e Vulcanologia
    Beschreibung: Published
    Beschreibung: 798167
    Beschreibung: 4A. Oceanografia e clima
    Beschreibung: JCR Journal
    Schlagwort(e): sea swell ; machine learning ; ocean waves ; micro-seismic data ; sea state ; sea wave period ; buoy ; Marine Science ; Oceanography
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Publikationsdatum: 2004-12-25
    Beschreibung: P-type ATPases extract energy by hydrolysis of adenosine triphosphate (ATP) in two steps, formation and breakdown of a covalent phosphoenzyme intermediate. This process drives active transport and countertransport of the cation pumps. We have determined the crystal structure of rabbit sarcoplasmic reticulum Ca2+ adenosine triphosphatase in complex with aluminum fluoride, which mimics the transition state of hydrolysis of the counterion-bound (protonated) phosphoenzyme. On the basis of structural analysis and biochemical data, we find this form to represent an occluded state of the proton counterions. Hydrolysis is catalyzed by the conserved Thr-Gly-Glu-Ser motif, and it exploits an associative nucleophilic reaction mechanism of the same type as phosphoryl transfer from ATP. On this basis, we propose a general mechanism of occluded transition states of Ca2+ transport and H+ countertransport coupled to phosphorylation and dephosphorylation, respectively.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Olesen, Claus -- Sorensen, Thomas Lykke-Moller -- Nielsen, Rikke Christina -- Moller, Jesper Vuust -- Nissen, Poul -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2251-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Structural Biology, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK-8000 Aarhus C, Denmark.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618517" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Diphosphate/chemistry/metabolism ; Adenosine Triphosphate/metabolism ; Aluminum Compounds/chemistry ; Amino Acid Motifs ; Animals ; Binding Sites ; Biological Transport, Active ; Calcium/metabolism ; Calcium-Transporting ATPases/*chemistry/*metabolism ; Chemistry, Physical ; Crystallization ; Crystallography, X-Ray ; Cytoplasm/metabolism ; Fluorides/chemistry ; Hydrolysis ; Ion Transport ; Models, Chemical ; Models, Molecular ; Phosphorylation ; Physicochemical Phenomena ; Protein Conformation ; Protein Structure, Tertiary ; *Protons ; Rabbits ; Sarcoplasmic Reticulum/enzymology ; Thapsigargin ; Thermodynamics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Publikationsdatum: 2004-12-18
    Beschreibung: Olig1 and Olig2 are closely related basic helix-loop-helix (bHLH) transcription factors that are expressed in myelinating oligodendrocytes and their progenitor cells in the developing central nervous system (CNS). Olig2 is necessary for the specification of oligodendrocytes, but the biological functions of Olig1 during oligodendrocyte lineage development are poorly understood. We show here that Olig1 function in mice is required not to develop the brain but to repair it. Specifically, we demonstrate a genetic requirement for Olig1 in repairing the types of lesions that occur in patients with multiple sclerosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arnett, Heather A -- Fancy, Stephen P J -- Alberta, John A -- Zhao, Chao -- Plant, Sheila R -- Kaing, Sovann -- Raine, Cedric S -- Rowitch, David H -- Franklin, Robin J M -- Stiles, Charles D -- 689/Multiple Sclerosis Society/United Kingdom -- NS08952/NS/NINDS NIH HHS/ -- NS11920/NS/NINDS NIH HHS/ -- NS4051/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2004 Dec 17;306(5704):2111-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15604411" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Animals, Newborn ; Basic Helix-Loop-Helix Transcription Factors ; Brain/growth & development/*physiology ; Cell Nucleus/metabolism ; Cuprizone/pharmacology ; Cytoplasm/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Demyelinating Diseases/*physiopathology ; Ethidium/pharmacology ; Humans ; Lysophosphatidylcholines/pharmacology ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis/physiopathology ; Myelin Sheath/*physiology ; Nerve Tissue Proteins/genetics/*metabolism/physiology ; Oligodendroglia/*physiology ; Rats ; Rats, Sprague-Dawley ; Spinal Cord/growth & development/*physiology ; Stem Cells/physiology ; Transcription Factors/genetics/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Publikationsdatum: 2004-12-18
    Beschreibung: Alfalfa mosaic virus genomic RNAs are infectious only when the viral coat protein binds to the RNA 3' termini. The crystal structure of an alfalfa mosaic virus RNA-peptide complex reveals that conserved AUGC repeats and Pro-Thr-x-Arg-Ser-x-x-Tyr coat protein amino acids cofold upon interacting. Alternating AUGC residues have opposite orientation, and they base pair in different adjacent duplexes. Localized RNA backbone reversals stabilized by arginine-guanine interactions place the adenosines and guanines in reverse order in the duplex. The results suggest that a uniform, organized 3' conformation, similar to that found on viral RNAs with transfer RNA-like ends, may be essential for replication.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500904/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500904/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guogas, Laura M -- Filman, David J -- Hogle, James M -- Gehrke, Lee -- AI20566/AI/NIAID NIH HHS/ -- GM42504/GM/NIGMS NIH HHS/ -- R01 AI020566/AI/NIAID NIH HHS/ -- R01 GM042504/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2004 Dec 17;306(5704):2108-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15604410" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 3' Untranslated Regions ; Alfalfa mosaic virus/*chemistry/*physiology ; Amino Acid Sequence ; Base Pairing ; Base Sequence ; Binding Sites ; Capsid Proteins/*chemistry/metabolism ; Crystallization ; Hydrogen Bonding ; Models, Molecular ; Molecular Sequence Data ; Nucleic Acid Conformation ; Protein Folding ; Protein Structure, Secondary ; RNA, Viral/*chemistry/metabolism ; Repetitive Sequences, Nucleic Acid ; *Virus Replication
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    facet.materialart.
    Unbekannt
    American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2004-12-18
    Beschreibung: Nutrient availability regulates life-span in a wide range of organisms. We demonstrate that in mammalian cells, acute nutrient withdrawal simultaneously augments expression of the SIRT1 deacetylase and activates the Forkhead transcription factor Foxo3a. Knockdown of Foxo3a expression inhibited the starvation-induced increase in SIRT1 expression. Stimulation of SIRT1 transcription by Foxo3a was mediated through two p53 binding sites present in the SIRT1 promoter, and a nutrient-sensitive physical interaction was observed between Foxo3a and p53. SIRT1 expression was not induced in starved p53-deficient mice. Thus, in mammalian cells, p53, Foxo3a, and SIRT1, three proteins separately implicated in aging, constitute a nutrient-sensing pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nemoto, Shino -- Fergusson, Maria M -- Finkel, Toren -- New York, N.Y. -- Science. 2004 Dec 17;306(5704):2105-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cardiovascular Branch, National Heart, Lung, and Blood Institute (NHLBI), Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15604409" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adipose Tissue/metabolism ; Animals ; Binding Sites ; Culture Media ; Culture Media, Serum-Free ; DNA-Binding Proteins/*metabolism ; Forkhead Transcription Factors ; Gene Deletion ; Genes, p53 ; Glucose ; HeLa Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Mutation ; PC12 Cells ; Promoter Regions, Genetic ; RNA, Small Interfering/pharmacology ; Rats ; Recombinant Fusion Proteins/metabolism ; Recombinant Proteins/metabolism ; Serum ; Sirtuin 1 ; Sirtuins/genetics/*metabolism ; *Starvation ; Transcription Factors/*metabolism ; Transcription, Genetic ; Tumor Suppressor Protein p53/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Publikationsdatum: 2004-12-18
    Beschreibung: Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceral fat of both humans and mice and whose expression level in plasma increases during the development of obesity. Visfatin corresponds to a protein identified previously as pre-B cell colony-enhancing factor (PBEF), a 52-kilodalton cytokine expressed in lymphocytes. Visfatin exerted insulin-mimetic effects in cultured cells and lowered plasma glucose levels in mice. Mice heterozygous for a targeted mutation in the visfatin gene had modestly higher levels of plasma glucose relative to wild-type littermates. Surprisingly, visfatin binds to and activates the insulin receptor. Further study of visfatin's physiological role may lead to new insights into glucose homeostasis and/or new therapies for metabolic disorders such as diabetes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fukuhara, Atsunori -- Matsuda, Morihiro -- Nishizawa, Masako -- Segawa, Katsumori -- Tanaka, Masaki -- Kishimoto, Kae -- Matsuki, Yasushi -- Murakami, Mirei -- Ichisaka, Tomoko -- Murakami, Hiroko -- Watanabe, Eijiro -- Takagi, Toshiyuki -- Akiyoshi, Megumi -- Ohtsubo, Tsuguteru -- Kihara, Shinji -- Yamashita, Shizuya -- Makishima, Makoto -- Funahashi, Tohru -- Yamanaka, Shinya -- Hiramatsu, Ryuji -- Matsuzawa, Yuji -- Shimomura, Iichiro -- New York, N.Y. -- Science. 2005 Jan 21;307(5708):426-30. Epub 2004 Dec 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine and Pathophysiology, Graduate School of Medicine, and Department of Organismal Biosystems, Graduate School of Frontier Biosciences, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15604363" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adipocytes/drug effects/metabolism ; Adipose Tissue/*metabolism ; Animals ; Binding Sites ; Blood Glucose/analysis ; Cell Line ; Cells, Cultured ; Cytokines/blood/genetics/*metabolism/pharmacology ; Diabetes Mellitus, Type 2/metabolism ; Dose-Response Relationship, Drug ; Female ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Gene Targeting ; Humans ; Insulin/blood/*metabolism ; Insulin Resistance ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Molecular Mimicry ; Muscle Cells/metabolism ; Nicotinamide Phosphoribosyltransferase ; Phosphorylation ; Receptor, Insulin/metabolism ; Recombinant Proteins/pharmacology ; Signal Transduction ; Subcutaneous Tissue ; Viscera
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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