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  • Animals  (1,550)
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  • 1
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    Breakthrough of the year. Small RNAs make big splash (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Couzin, Jennifer -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2296-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493875" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatin/chemistry/physiology ; DNA Transposable Elements ; Endoribonucleases/metabolism ; *Gene Expression Regulation ; Gene Silencing ; Heterochromatin/metabolism ; MicroRNAs/*physiology ; Plants/genetics ; *RNA Interference ; RNA, Double-Stranded/physiology ; RNA, Fungal/physiology ; RNA, Protozoan/physiology ; RNA, Small Interfering/*physiology ; Ribonuclease III ; Schizosaccharomyces/genetics ; Second Messenger Systems ; Tetrahymena/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Animal models. To build a better mouse cage (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2321.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493895" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation ; Animals ; *Animals, Laboratory ; *Behavior, Animal ; Environment ; *Housing, Animal ; Humans ; *Mice ; Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    A distinct signaling pathway used by the IgG-containing B cell antigen receptor (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: The immunoglobulin G (IgG)-containing B lymphocyte antigen receptor (IgG-BCR) transmits a signal distinct from that of IgM-BCR or IgD-BCR, although all three use the same signal-transducing component, Igalpha/Igbeta. Here we demonstrate that the inhibitory coreceptor CD22 down-modulates signaling through IgM-BCR and IgD-BCR, but not that through IgG-BCR, because of the IgG cytoplasmic tail, which prevents CD22 phosphorylation. These results suggest that the cytoplasmic tail of IgG specifically enhances IgG-BCR signaling by preventing CD22-mediated signal inhibition. Enhanced signaling through IgG-BCR may be involved in efficient IgG production, which is crucial for immunity to pathogens.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wakabayashi, Chisato -- Adachi, Takahiro -- Wienands, Jurgen -- Tsubata, Takeshi -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2392-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493916" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, CD/metabolism ; Antigens, Differentiation, B-Lymphocyte/metabolism ; B-Lymphocytes/immunology/metabolism ; Calcium/metabolism ; Calcium Signaling ; *Cell Adhesion Molecules ; Cells, Cultured ; Immunoglobulin D/immunology/metabolism ; Immunoglobulin G/chemistry/immunology/*metabolism ; Intracellular Signaling Peptides and Proteins ; Lectins/metabolism ; Mice ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3 ; Mitogen-Activated Protein Kinases/metabolism ; Phosphorylation ; Protein Tyrosine Phosphatase, Non-Receptor Type 6 ; Protein Tyrosine Phosphatases/metabolism ; Receptors, Antigen, B-Cell/chemistry/immunology/*metabolism ; Sialic Acid Binding Ig-like Lectin 2 ; *Signal Transduction ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Portraits of science. A Polish, Jewish scientist in 19th-century Prussia (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lagunoff, David -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2331.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, St. Louis University School of Medicine, St. Louis, MO 63104, USA. lagunofd@slucare1.sluh.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493897" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Biology/*history ; *Cell Division ; *Cell Physiological Phenomena ; Electric Stimulation Therapy/history ; Embryology/history ; Germany ; History, 19th Century ; Humans ; Judaism ; Neoplasms/pathology ; Nerve Fibers/ultrasonography ; Neuromuscular Diseases/history/therapy ; Neurons/cytology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Circadian rhythms. Carbon monoxide and clocks (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boehning, Darren -- Snyder, Solomon H -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2339-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493901" target="_blank"〉PubMed〈/a〉
    Keywords: ARNTL Transcription Factors ; Animals ; Autonomic Nervous System/metabolism ; Basic Helix-Loop-Helix Transcription Factors ; Behavior, Animal ; Brain/metabolism ; CLOCK Proteins ; Carbon Monoxide/*metabolism/pharmacology ; *Circadian Rhythm/genetics ; DNA/metabolism ; Diffusion ; Dimerization ; Helix-Loop-Helix Motifs ; Heme/metabolism ; Heme Oxygenase (Decyclizing)/metabolism ; Mice ; Models, Genetic ; NAD/metabolism ; NADP/metabolism ; Nerve Tissue Proteins/*chemistry/*metabolism ; Neurons/*metabolism ; Neurotransmitter Agents/metabolism ; Oxidation-Reduction ; Protein Structure, Tertiary ; Synaptic Transmission ; Trans-Activators/metabolism ; Transcription Factors/*chemistry/*metabolism ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Finding genes that underlie complex traits (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: Phenotypic variation among organisms is central to evolutionary adaptations underlying natural and artificial selection, and also determines individual susceptibility to common diseases. These types of complex traits pose special challenges for genetic analysis because of gene-gene and gene-environment interactions, genetic heterogeneity, low penetrance, and limited statistical power. Emerging genome resources and technologies are enabling systematic identification of genes underlying these complex traits. We propose standards for proof of gene discovery in complex traits and evaluate the nature of the genes identified to date. These proof-of-concept studies demonstrate the insights that can be expected from the accelerating pace of gene discovery in this field.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Glazier, Anne M -- Nadeau, Joseph H -- Aitman, Timothy J -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2345-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, Ducane Road, London W12 0NN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493905" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; Chromosome Mapping ; Genetic Linkage ; *Genetic Predisposition to Disease ; Genetic Variation ; Humans ; *Multifactorial Inheritance ; Mutation ; Phenotype ; Plants/genetics ; *Quantitative Trait Loci ; *Quantitative Trait, Heritable ; Saccharomyces cerevisiae/genetics ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Breakthrough of the year. The runners-up (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉New York, N.Y. -- Science. 2002 Dec 20;298(5602):2297-303.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493876" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Astronomical Phenomena ; Astronomy ; Biological Evolution ; Cosmic Radiation ; Elementary Particles ; Genome ; Hominidae ; Humans ; Ion Channels/physiology ; Lasers ; Light ; Microwaves ; Motion Pictures as Topic ; Optics and Photonics ; Retinal Ganglion Cells/physiology ; Rod Opsins/physiology ; *Science ; Sequence Analysis, DNA ; Temperature ; Tomography/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    California budget. Latest cuts send universities reeling (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lawler, Andrew -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493882" target="_blank"〉PubMed〈/a〉
    Keywords: Academies and Institutes/economics ; Animals ; Biological Specimen Banks ; *Budgets ; California ; Ecosystem ; Oceanography ; Research/*economics ; Seawater ; Universities/*economics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Animal models. Can a mouse be standardized? (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bohannon, John -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493894" target="_blank"〉PubMed〈/a〉
    Keywords: Animal Experimentation ; Animals ; *Animals, Laboratory ; *Behavior, Animal ; Drug Industry ; Environment ; Housing, Animal ; *Mice ; *Mice, Mutant Strains ; Models, Animal ; Social Behavior ; *Stereotyped Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    CREM-dependent transcription in male germ cells controlled by a kinesin (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-21
    Description: ACT is a LIM-only protein expressed exclusively in round spermatids, where it cooperates with transcriptional activator CREM in regulating various postmeiotic genes. Targeted inactivation of CREM leads to a complete block of mouse spermiogenesis. We sought to identify the regulatory steps controlling the functional interplay between CREM and ACT. We found that ACT selectively associates with KIF17b, a kinesin highly expressed in male germ cells. The ACT-KIF17b interaction is restricted to specific stages of spermatogenesis and directly determines the intracellular localization of ACT. Sensitivity to leptomycin B indicates that KIF17b can be actively exported from the nucleus through the Crm1 receptor. Thus, a kinesin directly controls the activity of a transcriptional coactivator by a tight regulation of its intracellular localization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Macho, Betina -- Brancorsini, Stefano -- Fimia, Gian Maria -- Setou, Mitsutoshi -- Hirokawa, Nobutaka -- Sassone-Corsi, Paolo -- New York, N.Y. -- Science. 2002 Dec 20;298(5602):2388-90.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Genetique et de Biologie Moleculaire et Cellulaire, B. P. 10142, 67404 Illkirch, Strasbourg, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12493914" target="_blank"〉PubMed〈/a〉
    Keywords: 3T3 Cells ; Amino Acid Sequence ; Animals ; COS Cells ; Cell Nucleus/metabolism ; Cyclic AMP Response Element Modulator ; Cytoplasm/metabolism ; DNA-Binding Proteins/metabolism ; Fatty Acids, Unsaturated/pharmacology ; Gene Expression Regulation, Developmental ; Karyopherins/metabolism ; Kinesin/chemistry/genetics/*metabolism ; LIM Domain Proteins ; Male ; Mice ; Molecular Motor Proteins/chemistry/genetics/*metabolism ; Molecular Sequence Data ; Promoter Regions, Genetic ; Protein Isoforms/chemistry/genetics/metabolism ; *Receptors, Cytoplasmic and Nuclear ; *Repressor Proteins ; Spermatids/*metabolism ; *Spermatogenesis ; Testis/metabolism ; Transcription Factors/genetics/*metabolism ; *Transcription, Genetic ; Transcriptional Activation ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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