Publication Date:
1995-11-24
Description:
Some growth factors are therapeutically useful partly because restricted expression of their receptors limits their action to particular cell types. However, no unique stimulatory factor is known for many clinically relevant cell types, such as CD34+ hematopoietic stem cells. Here, soluble alpha receptor (R alpha) components for interleukin-6 (IL-6) and ciliary neurotrophic factor (CNTF) were targeted in an active form to cells expressing surface markers such as CD34 or CD45, thereby rendering those cells responsive to IL-6 or CNTF. The targeting of R alpha components may provide the means to create "designer" cytokines that activate a desired cell type expressing a specific cell surface marker.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Economides, A N -- Ravetch, J V -- Yancopoulos, G D -- Stahl, N -- New York, N.Y. -- Science. 1995 Nov 24;270(5240):1351-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Regeneron Pharmaceuticals, Tarrytown, NY 10591, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481821" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal
;
Antigens, CD/immunology/*metabolism
;
Antigens, CD34/analysis
;
Antigens, CD45/analysis
;
Cell Division
;
Cell Line
;
Cell Membrane/*metabolism
;
Ciliary Neurotrophic Factor
;
Cytokine Receptor gp130
;
*Growth Inhibitors
;
Humans
;
Immunoglobulin Fc Fragments
;
Interleukin-6/*pharmacology
;
Leukemia Inhibitory Factor
;
Leukemia Inhibitory Factor Receptor alpha Subunit
;
*Lymphokines
;
Membrane Glycoproteins/metabolism
;
Nerve Tissue Proteins/*pharmacology
;
Phosphorylation
;
Receptor, Ciliary Neurotrophic Factor
;
Receptors, Cytokine/metabolism
;
Receptors, Fc
;
Receptors, Interleukin/immunology/*metabolism
;
Receptors, Interleukin-6
;
Receptors, Nerve Growth Factor/immunology/*metabolism
;
Receptors, OSM-LIF
;
Recombinant Fusion Proteins/metabolism
;
Solubility
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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