Publication Date:
2007-12-01
Description:
JAM-C is an adhesion molecule that is expressed on cells within the vascular compartment and epithelial cells and, to date, has been largely studied in the context of inflammatory events. Using immunolabeling procedures in conjunction with confocal and electron microscopy, we show here that JAM-C is also expressed in peripheral nerves and that this expression is localized to Schwann cells at junctions between adjoining myelin end loops. Sciatic nerves from JAM-C-deficient [having the JAM-C gene knocked out (KO)] mice exhibited loss of integrity of the myelin sheath and defective nerve conduction as indicated by morphological and electrophysiological studies, respectively. In addition, behavioral tests showed motor abnormalities in the KO animals. JAM-C was also expressed in human sural nerves with an expression profile similar to that seen in mice. These results demonstrate that JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299566/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299566/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Scheiermann, Christoph -- Meda, Paolo -- Aurrand-Lions, Michel -- Madani, Rime -- Yiangou, Yiangos -- Coffey, Peter -- Salt, Thomas E -- Ducrest-Gay, Dominique -- Caille, Dorothee -- Howell, Owain -- Reynolds, Richard -- Lobrinus, Alexander -- Adams, Ralf H -- Yu, Alan S L -- Anand, Praveen -- Imhof, Beat A -- Nourshargh, Sussan -- 064920/Wellcome Trust/United Kingdom -- PG/03/123/16102/British Heart Foundation/United Kingdom -- R01 DK062283/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2007 Nov 30;318(5855):1472-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Heart and Lung Institute, Imperial College London, London, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18048693" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Animals
;
Cell Adhesion Molecules/*metabolism
;
Humans
;
Immunoglobulins/*metabolism
;
Intercellular Junctions/metabolism
;
Membrane Proteins/*metabolism
;
Mice
;
Mice, Knockout
;
Myelin Sheath/metabolism/*physiology/ultrastructure
;
Nerve Fibers, Myelinated/metabolism/*physiology/ultrastructure
;
Neural Conduction
;
Peripheral Nerves/*metabolism/physiology
;
Peripheral Nervous System Diseases/metabolism/pathology/physiopathology
;
Schwann Cells/*metabolism
;
Sciatic Nerve/metabolism/physiology/ultrastructure
;
Sural Nerve/metabolism/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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