ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Online-Ressource

Notch Signaling in Embryology and Cancer : Molecular Biology of Notch Signaling (2020)

Reichrath, Jörg. [editor.] ; Reichrath, Sandra. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.

Beschreibung / Inhaltsverzeichnis: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.

Kurzfassung: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.

Materialart: Online-Ressource

Seiten: XIII, 172 p. 32 illus., 31 illus. in color. , online resource.

Ausgabe: 2nd ed. 2020.

ISBN: 9783030364229

Serie: Advances in Experimental Medicine and Biology, 1227

URL: https://doi.org/10.1007/978-3-030-36422-9

DOI: 10.1007/978-3-030-36422-9

DDC: 571.978

Sprache: Englisch

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Tumor Microenvironment : Molecular Players – Part B (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.

Beschreibung / Inhaltsverzeichnis: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.

Kurzfassung: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Materialart: Online-Ressource

Seiten: XIV, 162 p. 22 illus., 21 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030502249

Serie: Advances in Experimental Medicine and Biology, 1277

URL: https://doi.org/10.1007/978-3-030-50224-9

DOI: 10.1007/978-3-030-50224-9

DDC: 571.978

Sprache: Englisch

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Immunotherapy for Gastrointestinal Malignancies (2020)

Vadde, Ramakrishna. [editor.] ; Nagaraju, Ganji Purnachandra. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Biochemical markers. ; Immunotherapy. ; Cancers. ; Biomarkers. ; Immunotherapy.

Beschreibung / Inhaltsverzeichnis: 1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy -- 2 immune composition of gastrointestinal tract of Gut -- 3 Immunomarkers for detection of GI malignancies -- 4 Immuno-therapeutics of gastrointestinal malignancies -- 5 Immune cell therapy against gastrointestinal tract cancers -- 6 Immune checkpoint inhibitors in gastrointestinal malignancies -- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers -- 8 Therapeutic Vaccines for Gastrointestinal Malignancies -- 9 Immuno-Oncology of Oesophageal Cancer -- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies -- 11 Immuno-oncology of colorectal cancer -- 12 Immune targets in colorectal cancer -- 13 Applications of computational biology in gastrointestinal malignancies. .

Kurzfassung: This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. .

Materialart: Online-Ressource

Seiten: XII, 251 p. 34 illus., 27 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811564871

Serie: Diagnostics and Therapeutic Advances in GI Malignancies,

URL: https://doi.org/10.1007/978-981-15-6487-1

DOI: 10.1007/978-981-15-6487-1

DDC: 571.978

Sprache: Englisch

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Lipid Metabolism in Tumor Immunity (2021)

Li, Yongsheng. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.

Beschreibung / Inhaltsverzeichnis: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.

Kurzfassung: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .

Materialart: Online-Ressource

Seiten: XI, 211 p. 24 illus., 23 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9789813367852

Serie: Advances in Experimental Medicine and Biology, 1316

URL: https://doi.org/10.1007/978-981-33-6785-2

DOI: 10.1007/978-981-33-6785-2

DDC: 571.978

Sprache: Englisch

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Autophagy in tumor and tumor microenvironment (2020)

Bhutia, Sujit Kumar. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.

Kurzfassung: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

Materialart: Online-Ressource

Seiten: VII, 280 p. 38 illus., 37 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811569302

URL: https://doi.org/10.1007/978-981-15-6930-2

DOI: 10.1007/978-981-15-6930-2

DDC: 571.978

Sprache: Englisch

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Biodiversity in India: Status, Issues and Challenges (2022)

Kaur, Shalinder. [editor.] ; Batish, D.R. [editor.] ; Singh, H.P. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Conservation biology. ; Biotic communities. ; Population biology. ; Plant ecology. ; Animal culture. ; Ecology. ; Conservation Biology. ; Community and Population Ecology. ; Plant Ecology. ; Animal Science.

Beschreibung / Inhaltsverzeichnis: Section 1 -- Chapter 1. Introduction -- Section 2. Plant Diversity -- Chapter 2. Status, issues and challenges of biodiversity:Lower plants (Non-vascular) -- Chapter 3. Status, issues and Challenges of Biodiversity:Higher Plants -- Chapter 4. Status, issues and challenges of biodiversity: Trees and Shrubs -- Chapter 5. Underutilized Plant Strength of India -- Section 3. Faunal Diversity -- Chapter 6. Status, Issues and Challenges of Biodiversity: Invertebrate -- Chapter 7. Diversity, Distribution and Endemicity of Herpetofauna in Different Biogeographic Zones and Biodiversity Hotpots of India -- Chapter 8. Status, Issues, and Challenges of Biodiversity: Wild Animals -- Chapter 9. Indian Avian Diversity:Status, Challenges and Solutions -- Chapter 10. Status, Issues and Challenges of Indian Livestock Biodiversity -- Section 4. Ecosystem Diversity -- Chapter 11. Agricultural Crop Diversity: Status, Challenges and Solutions -- Chapter 12. Biodiversity of Agriculturally Important Insects: Status, Issues and Challenges -- Chapter 13. Biodiversity Issues and Challenges:Non-Agriculture Insects -- Chapter 14. Status, issues and challenges of biodiversity: Forest Insects -- Chapter 15. Status, Issues and Challenges of Biodiversity: Marine Biota -- Chapter 16. Diatoms the living jewels their biodiversity, phycosphere and associated phenotypic plasticity: a lesson to learn from current pandemic of corona virus -- Chapter 17. Plant Diversity at Ecosystems level in India: Dynamics and Status -- Chapter 18. Faunal Diversity at Ecosystems level in India: Dynamics and Status -- Section 5. Challenges and reasons of Biodiversity loss -- Chapter 19. Challenges on Account of Invasive Alien Terrestrial Plants -- Chapter 20. Alien Invasive Aquatic Fauna:Challenges and Mitigation -- Chapter 21. Reasons of Biodiversity Loss in India -- Section 6. Efforts Conservation -- Chapter 22. Conservation of National Biodiversity: Efforts of the Indian Government -- Chapter 23. Legal Framework for Conservation of Biodiversity in India -- Chapter 24. Index.

Kurzfassung: This contributed book is based on the current status of biodiversity in India, issues and challenges faced by the authorities involved in conservation efforts, and the imperative role of various direct and indirect stakeholders in biodiversity conservation. The book discusses the current status of different forms of biodiversity in India, challenges faced by stakeholders, issues and reasons for biodiversity losses, and efforts by government through various laws, policies, and programs in a concise and comprehensive manner throughout its many chapters. In this way, readers can access diverse information on Indian biodiversity through this book. It is compiled by leading experts in the field of conservation. In 18 chapters, it covers biodiversity of both fauna and flora, on land and in aquatic ecosystems, legal and policy aspects, as well as innovative conservation tool and techniques. It is useful for undergraduates and graduate students and also educates policy planners, bureaucrats, foresters, and researchers in India and abroad.

Materialart: Online-Ressource

Seiten: X, 665 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9789811697777

URL: https://doi.org/10.1007/978-981-16-9777-7

DOI: 10.1007/978-981-16-9777-7

DDC: 577

Sprache: Englisch

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Tumor Microenvironment : Signaling Pathways – Part B (2021)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.

Beschreibung / Inhaltsverzeichnis: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Materialart: Online-Ressource

Seiten: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030471897

Serie: Advances in Experimental Medicine and Biology, 1270

URL: https://doi.org/10.1007/978-3-030-47189-7

DOI: 10.1007/978-3-030-47189-7

DDC: 571.978

Sprache: Englisch

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The Systemic Effects of Advanced Cancer : A Textbook on Cancer-Associated Cachexia (2022)

Acharyya, Swarnali. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Oncology. ; Immunology. ; Metastasis. ; Cytology. ; Cancer Biology. ; Oncology. ; Immunology. ; Metastasis. ; Cell Biology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.

Kurzfassung: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.

Materialart: Online-Ressource

Seiten: VI, 203 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783031095184

URL: https://doi.org/10.1007/978-3-031-09518-4

DOI: 10.1007/978-3-031-09518-4

DDC: 571.978

Sprache: Englisch

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Ecosystem and Species Habitat Modeling for Conservation and Restoration (2023)

Dhyani, Shalini. [editor.] ; Adhikari, Dibyendu. [editor.] ; Dasgupta, Rajarshi. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology Methodology. ; Biotic communities. ; Plant ecology. ; Ecological Modelling. ; Ecosystems. ; Plant Ecology.

Beschreibung / Inhaltsverzeichnis: 1. Modelling tools and plausible scenarios in science-policy to improve evidence based decision making for human-well-being -- 2. Basic Introduction to Species Distribution Modelling -- 3. Machine Learning based predictive modelling approaches for better understanding evolutionary history, distribution and niche occupancy: Experience from Western Ghats -- 4. Mapping the impact of climate change on eco-sensitive hotspots using species distribution modelling (SDMs) – Gaps, Challenges and Future Perspectives -- 5. Approaches for modelling the climate change impacts on ecosystems -- 6. Developing a Bayesian Model of Climate-Induced Lake Overturn in Talisay, Taal Lake -- 7. Global sensitivity and uncertainty analysis of MaxEnt model: Implications in species habitat projections -- 8. Tree species diversity and richness patterns reveal high priority areas for conservation in Eswatini -- 9. Improving the conservation status of a threatened tree (Acer sikkimensis Miq. syn. Acer hookeri Miq.) through standardization of seed germination protocol and using ecological niche modeling -- 10. Ecological Niche Modeling of the endemic Himalayan near-threatened treeline conifer Abies spectabilis (D.Don) Mirb. in the Indian Central Himalaya -- 11. Modeling the distribution of a medicinal plant Oroxylum indicum (L.) Kurz for its conservation in Arunachal Pradesh -- 12. Habitat Suitability and Niche Modeling for Conservation and Restoration of Aconitum heterophyllum Wall. in Temperate Himalayan Forest Ecosystem -- 13. Application of species distribution modeling for conservation and restoration of forest ecosystems -- 14. Habitat suitability analysis of Asiatic Elephants (Elephas maximus) in the Tropical Moist Deciduous Forest of Assam using Analytic Hierarchy Process (AHP) -- 15. Factors Affecting the Habitat Suitability of Eastern Swamp Deer (Rucervus duvaucelii ranjitsinhi Groves, 1982) in Manas National Park and Implication for Terai Grassland Restoration -- 16. Evaluating Potential Habitats of Chital, Sloth Bear and Jungle Cat in Selected Areas of Central Indian Landscape -- 17. Habitat suitability modeling of Tor tor (Hamilton, 1822) in the Indian drainage systems using MaxEnt -- 18. Modelling the influence of Marine Fishery Advisories on the reduction of Carbon Dioxide emissions for Odisha under varying Climate Change Scenarios using CMIP models – an evidence-based approach for policymaking -- 19. Impacts of pollution on tropical montane and temperate forests of South Asia: Preliminary studies by post graduate students in India and Sri Lanka -- 20. Selection of strategic sampling sites for river quality assessments near mined areas as a policy handle for low-impact development and biodiversity conservation – a case study of River Godavari -- 21. Ecological niche modeling predicts the potential area for cultivation of Melia dubia Cav. (Meliaceae): a promising tree species for agroforestry in India -- 22. Proportions of change in the airborne particulate matter (PM10) concentrations across selected states in Peninsular India - a study of decadal, pre-pandemic trends for planning restoration -- 23. Decomposition of Sunflower Cuttings and its Impact on Soil Fertility of Rice Terraces (Payoh) in Banaue, Ifugao, Philippines -- 24. Forest ecosystem modeling for policy planning: A review -- 25. Ecological Carrying Capacity Modelling and Sustainability Assessment of the Seven Lakes of San Pablo City, Laguna, Philippines -- 26. Assessment of the contribution of Fresh Water Ecosystem Services to the Hydropower Sector in the Kura-Araz basin -- 27. Eutrophication modelling of Chilika Lagoon using an artificial neural network approach.

Kurzfassung: This edited book is focused on SDG 15. This volume covers aspects of species and ecosystem modeling in understanding the complexity of ecological systems, restoration, protected area management, and species conservation. The book follows a systematic and situation-sensitive approach to discuss ecosystem and species modeling tools, approaches, science, case studies, opportunities, and gaps for enhancing conservation efforts, ensuring ecosystem resilience, and addressing sustainability issues. The book emphasizes on science, innovations, case studies, and strategic relevance as main pillars of using ecosystem and species modeling tools and implementing the outcomes and results. In addition, clear conceptual frameworks, elaborated methodologies, and their applications are included to support policy planning and interventions to reduce and reverse human encroachment in human-dominated natural ecosystems, their degradation, and loss of important species and ecosystem services. Essential information with a special focus on advances and opportunities in advancing the implementation of results and outputs of the modeling tools, challenges and constraints for addressing loss of ecosystem services, designing and implementing sustainable landscape restoration, environmental risk assessment, and finally understanding policy implications and concerns for mainstreaming modeling results in conservation planning and decision-making is included in the book. Further topics include ultimate translational value of modeling tools and efforts across transitional ecosystems and species habitat to provide better evidence to influence the nature-based solutions (NbS) and ecosystem health assessment using Red List of Ecosystems (RLE). The emerging roles of integrative socio-ecological as well as techno-cultural factors in promoting the relevance of ecosystem and species modeling is one of the key features of this book. This edited volume is of interest and useful to researchers, students, scholars, policy makers, forest managers, consultants, and policy makers in the fields of protected area management, forest department, conservation, modeling, climate change, and sustainability science, and also authors engaged in IPBES, IPCC, and several other assessments.

Materialart: Online-Ressource

Seiten: XXXV, 570 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819901319

URL: https://doi.org/10.1007/978-981-99-0131-9

DOI: 10.1007/978-981-99-0131-9

DDC: 577

Sprache: Englisch

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Cancer Biology: How Science Works (2021)

Carlberg, Carsten. ; Velleuer, Eunike.

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.

Beschreibung / Inhaltsverzeichnis: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.

Kurzfassung: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.

Materialart: Online-Ressource

Seiten: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030756994

URL: https://doi.org/10.1007/978-3-030-75699-4

DOI: 10.1007/978-3-030-75699-4

DDC: 571.978

Sprache: Englisch

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Obesity and Cancer (2021)

Kumar, Shashank. [editor.] ; Gupta, Sanjay. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Diseases. ; Immunology. ; Bioinformatics. ; Cancer Biology. ; Diseases. ; Immunology. ; Bioinformatics.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Obesity induced chronic low-level inflammation and cancers -- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers -- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation -- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer -- Chapter 6. Immune response and oxidative stress in obesity induced cancer -- Chapter 7. Role of gene polymorphism in obesity and cancer -- Chapter 8. Therapeutic role of green tea in obesity and cancer -- Chapter 9. Effect of dietary phytochemicals in obesity and cancer -- Chapter 10. Resveratrol as anti-obesity and anticancer agent -- Chapter 11. EGCG as anti-obesity and anticancer agent -- Chapter 12. miRNAs as therapeutic target in obesity and cancer -- Chapter 13. In silico updates on lead identification for obesity and cancer -- Chapter 14. In vivo models for obesity and obesity related carcinogenesis -- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases -- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.

Kurzfassung: This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. .

Materialart: Online-Ressource

Seiten: IX, 361 p. 38 illus., 23 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9789811618468

URL: https://doi.org/10.1007/978-981-16-1846-8

DOI: 10.1007/978-981-16-1846-8

DDC: 571.978

Sprache: Englisch

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Theories in Ecological Risk Assessment (2023)

Kamo, Masashi.

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Environmental sciences Mathematics. ; Environment. ; Conservation biology. ; Statistics . ; Ecology. ; Mathematical Applications in Environmental Science. ; Environmental Sciences. ; Conservation Biology. ; Statistics.

Beschreibung / Inhaltsverzeichnis: 0. Introduction - Ecologist in Wonderland -- Part 1. Linking Ecotoxicology and Ecology -- Chapter 1. Basic Concepts of Ecological Risk Assessment -- Chapter 2. Population-level assessment -- Chapter 3. Population models of extinction -- Chapter 4. Population level assessment using the canonical model -- Part 2. Models for ecotoxicology -- Chapter 5. Species Sensitivity Distribution in Ecological Risk Assessment -- Chapter 6. BLM: A model for predicting metal toxicities -- Chapter 7.Mathematical models for chemical mixtures -- Chapter 8.Statistics and related topics.

Kurzfassung: This book introduces various mathematical models used in ecological risk assessment, primarily discussing models used in hazard assessment. The book aims to link ecology and conservation biology with risk assessments, bringing together the knowledge of ecotoxicology and ecology for effective risk assessment. The first part describes population-level assessment in ecological risk assessment. The chapters cover current methodologies for ecological risk assessment, individual-level assessment, population dynamics models for population-level assessment, case studies, mathematical models for population extinctions, the derivation of mean time to extinction (MTE) and their case studies. The second part of the book discusses the mathematical models involved in hazard assessments. It introduces the method of risk assessment using species sensitivity distributions (SSDs), hazard assessment of metals, chemical mixtures using the Michaelis-Menten equation, basic elements of statistics and related topics. Expected readers are risk assessors in governments and public sectors, students and young researchers interested in environmental science. The book is made accessible and easy to follow by beginners in mathematical biology and theoretical ecology.

Materialart: Online-Ressource

Seiten: XIV, 202 p. 90 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819903092

Serie: Theoretical Biology,

URL: https://doi.org/10.1007/978-981-99-0309-2

DOI: 10.1007/978-981-99-0309-2

DDC: 577

Sprache: Englisch

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Tumor Microenvironment : Extracellular Matrix Components – Part A (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.

Beschreibung / Inhaltsverzeichnis: The tumor microenvironment: focus on extracellular matrix -- Keratan Sulphate in the Tumour Environment -- Hyaluronan in the tumor microenvironment -- Fibronectin in the tumor microenvironment -- Matrix metalloproteinases role in tumor microenvironment -- Flipping the Molecular Switch: Influence of Perlecan and its Modifiers in the Tumor Microenvironment -- Heparan sulfate in the tumor microenvironment -- The role of Glypican-1 in the tumour microenvironment -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components with the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newer generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book will be an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Materialart: Online-Ressource

Seiten: XI, 181 p. 29 illus., 24 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030401467

Serie: Advances in Experimental Medicine and Biology, 1245

URL: https://doi.org/10.1007/978-3-030-40146-7

DOI: 10.1007/978-3-030-40146-7

DDC: 571.978

Sprache: Englisch

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Current Advances in the Science of Osteosarcoma : Research Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, and Canine Models (2020)

Kleinerman, Eugenie S. [editor.] ; Gorlick, Richard. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Medical microbiology. ; Cytology. ; Pediatrics. ; Cancer Biology. ; Medical Microbiology. ; Cell Biology. ; Pediatrics.

Beschreibung / Inhaltsverzeichnis: The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index.

Kurzfassung: This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.

Materialart: Online-Ressource

Seiten: XIII, 233 p. 34 illus., 23 illus. in color. , online resource.

Ausgabe: 2nd ed. 2020.

ISBN: 9783030430856

Serie: Advances in Experimental Medicine and Biology, 1258

URL: https://doi.org/10.1007/978-3-030-43085-6

DOI: 10.1007/978-3-030-43085-6

DDC: 571.978

Sprache: Englisch

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River Dynamics and Flood Hazards : Studies on Risk and Mitigation (2023)

Pandey, Manish. [editor.] ; Azamathulla, Hazi. [editor.] ; Pu, Jaan H. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Biotic communities. ; Freshwater ecology. ; Marine ecology. ; Ecosystems. ; Freshwater and Marine Ecology.

Beschreibung / Inhaltsverzeichnis: Part (I) Introduction to river hazards and their management: Chapter 1. Natural River Hazards: Their Impacts and Mitigation Techniques -- Chapter 2. Assessment of sediment hazard and associated measurement -- Chapter 3. Modelling approach to study the riverine flood hazard of lower Damodar river -- Chapter 4. Field measurement of accumulated surface water and infiltration depth in a flood-prone Langol catchment of Manipur valley region -- Chapter 5. Soil erosion analysis with respect to land use / land cover change in Godavari basin -- Part (II) Stability of Hydraulic Structures and Sediment Transport: Chapter 6. Stability of hydraulic structures against erosion and scour due to water jets -- Chapter 7. Stabilization of Manmade Embankments at Indian Sundarban Estuary through Turbulence Control at Flow-Sediment Interface: Field Survey and Flume Experimentation -- Chapter 8. A Review of Sedimentation on Different Types of Weirs -- Chapter 9. A Review on Parametric Studies of Piano Key Weir -- Chapter 10 Influence of boundary condition on the modified 2D shallow water model near the flow-structure interaction zone: a case study in Brahmaputra River -- Chapter 11. A Review on Estimation Methods of Scour Depth around Bridge Pier -- Chapter 12. Estimation of Shear force Distribution in Two-stage open channel using SVM and ANFIS -- Chapter 13. Sediment transport modelling through machine learning methods: Review of current challenges and strategies -- Chapter 14. Impact of Anthropocene on the fluvial sediment supply: The Mahanadi River basin perspective -- Chapter 15. Assessment of sediment hazards by bed level variations around the bridge pier -- Chapter 16. Equation development for equilibrium bed load -- Part (III) Hydrological hazards and ecological restoration: Chapter 17. Flood mitigation with river restoration using Porcupine systems -- Chapter 18. Flood prioritisation of basins based on geomorphometric properties using Morphometric analysis and Principal component analysis: A case study of the Maner River basin -- Chapter 19. Flood modelling of Krishna river at Sangli using HEC-RAS -- Chapter 20. Development of Machine Learning based Flood Prediction Model for Godavari River Basin -- Chapter 21. Field study on soil organic matter content in inundation areas of Langol catchment by loss- on-ignition” method -- Chapter 22. Agricultural Drought Assessment using Satellite based Surface Soil Moisture Estimate -- Chapter 23. A Review on Hydrodynamics of Vegetated Streams -- Chapter 24. Analysis of Stormwater Drainage Network of the Central Zone in the Surat City by Using SWMM 5.1 Software -- Chapter 25. Review of state-of-the-art research on river hydrological hazards, restoration and management -- Chapter 26. Erosion Susceptibility Mapping based on Hypsometric Analysis using Remote Sensing and Geographical Information System Techniques -- Part (IV) Climate change and Global warming issues: Chapter 27. Climate Change Implication and Adaptation for River systems -- Chapter 28. Non-parametric approaches to identify rainfall pattern in semi-arid regions: Ranipet, Vellore, and Tirupathur districts, Tamil Nadu, India -- Chapter 29. Decadal-based analysis of hydrological components in the Kesinga sub-catchment in Mahanadi Basin: An assessment of climate variability impact -- Chapter 30. Prediction of Future Rainfall in the Upper Godavari Basin Using Statistical Downscaling Model -- Chapter 31. Projecting Future Maximum Temperature Changes in River Ganges Basin using Observations and Statistical Downscaling Model (SDSM) -- Chapter 32. Trend Assessment of Rainfall over Mumbai and Pune Cities -- Chapter 33. Evaluation of Potential lakes Susceptible to GLOF using Multi-Criteria Assessment in Jhelum Sub-basin of Indus Basin.

Kurzfassung: This edited book covers all aspects of River related disasters, challenges, and opportunities. Step-by-step descriptions are provided of river dynamics and associated hazards, and their applications in hazard assessments, accompanied by several experimental, filed and numerical studies. In addition, a systematic table of content is given to aid in identifying River hazards challenges and opportunities. Essential information is provided on River dynamics, hydrological processes and climate change issues, and an individual chapter is devoted to ecological restoration and river hazard management. Further topics include the stability of hydraulic structures, sediment transport, and debris flow in the hilly streams. This book will provide students, researchers, scientists, water resources managers with a comprehensive overview of the River dynamics and flood hazards in various sectors of water-related disasters and will enable them to explore the scope of application of the computational techniques and will enable them to explore the scope of River related disasters, allied branches and their field-specific problems. Professionals and policymakers may also explore the implementation of these approaches in their workplace to tackle complex river dynamics and hydrological phenomena occurring in their study area.

Materialart: Online-Ressource

Seiten: X, 624 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811971006

Serie: Disaster Resilience and Green Growth,

URL: https://doi.org/10.1007/978-981-19-7100-6

DOI: 10.1007/978-981-19-7100-6

DDC: 577

Sprache: Englisch

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Heparanase : From Basic Research to Clinical Applications (2020)

Vlodavsky, Israel. [editor.] ; Sanderson, Ralph D. [editor.] ; Ilan, Neta. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.

Beschreibung / Inhaltsverzeichnis: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.

Kurzfassung: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Materialart: Online-Ressource

Seiten: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030345211

Serie: Advances in Experimental Medicine and Biology, 1221

URL: https://doi.org/10.1007/978-3-030-34521-1

DOI: 10.1007/978-3-030-34521-1

DDC: 571.978

Sprache: Englisch

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Airborne Particulate Matter : Source, Chemistry and Health (2022)

Sonwani, Saurabh. [editor.] ; Shukla, Anuradha. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Biotic communities. ; Ecology . ; Environmental chemistry. ; Environmental sciences Social aspects. ; Ecosystems. ; Ecology. ; Environmental Chemistry. ; Environmental Social Sciences.

Beschreibung / Inhaltsverzeichnis: 1 Introduction to Airborne Particulate Matter - Source, Chemistry and Health -- 2 Emission Sources of Particulate Matter -- 3 Geographic Distribution and Transport of Atmospheric Particulate Matter -- 4 Airborne particles in indoor and outdoor environments -- 5 High-resolution ambient record of aerosols over Delhi and associated typical health effects -- 6 Characterization of Primary and Secondary Airborne Particulate -- 7 Toxicological implications of fine particulates: sources, chemical composition and possible underlying mechanism -- 8 Bioaerosol and its impact on human health -- 9 Human Health Effects of Particulate Matter -- 10 Impacts and Responses of Particulate Matter Pollution on Vegetation -- 11 Mitigation and Management of Ambient Particulate Matter -- 12 Particulate Matter Regulatory Policies: National and Global Approach. .

Kurzfassung: This book is about airborne particulate matter, sources, chemistry and health and contained a complete information about their emission source, transport, atmospheric chemistry, distribution at local, regional and global levels, and their level in indoor and outdoor settings. Primary and secondary particulate matters in the ambient atmosphere also describe in detail. Analytical techniques, statistical tools and mathematical models used in airborne particulate research is also described. This book also covers the important aspects of the particulate matter chemistry in atmosphere, and their adverse impact on plant and human health. A detailed insight about the harmful impact of airborne particulate matter (biogenic and anthropogenic both) on different human system is described in detail. The toxicological significance of particulate matter on human body was also mentioned. The mitigation, management and regulatory policies to control ambient particulate matter is also provided. This book is also written in simple language with helpful photographs, diagrams, tables and flowcharts which will make the reader comfortable in understanding the concepts a more relatively easier way. Overall, the present book is a valuable tool for students working in the fields of Atmospheric Science, Environmental Science, Biological Sciences, Epidemiology and Agriculture Science. This book also a unique resource for environmental consultants, researchers, policymakers and other professionals involved in air quality, plant and human health.

Materialart: Online-Ressource

Seiten: XIX, 314 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9789811653872

URL: https://doi.org/10.1007/978-981-16-5387-2

DOI: 10.1007/978-981-16-5387-2

DDC: 577

Sprache: Englisch

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POLAR NIGHT Marine Ecology : Life and Light in the Dead of Night (2020)

Berge, Jørgen. [editor.] ; Johnsen, Geir. [editor.] ; Cohen, Jonathan H. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Biodiversity. ; Freshwater ecology. ; Marine ecology. ; Climatology. ; Physical geography. ; Botanical chemistry. ; Ecosystems. ; Biodiversity. ; Freshwater and Marine Ecology. ; Climate Sciences. ; Physical Geography. ; Plant Biochemistry.

Beschreibung / Inhaltsverzeichnis: Preface -- The marine physical environment during the Polar Night -- Light in the Polar Night -- Marine micro- and macroalgae in the Polar Night -- Zooplankton in the Polar Night -- Benthic communities in the Polar Night -- Fish ecology in the Polar Night -- Biological clocks and rhythms in polar organisms -- Sensor carrying platforms -- Operative habitat mapping and monitoring in the Polar Night -- The Polar Night exhibition: Life and light at the dead of night -- Index.

Kurzfassung: Until recently, the prevailing view of marine life at high latitudes has been that organisms enter a general resting state during the dark Polar Night and that the system only awakens with the return of the sun. Recent research, however, with coordinated, multidisciplinary field campaigns based on the high Arctic Archipelago of Svalbard, have provided a radical new perspective. Instead of a system in dormancy, a new perspective of a system in full operation and with high levels of activity across all major phyla is emerging. Examples of such activities and processes include: Active marine organisms at sea surface, water column and the sea-floor. At surface we find active foraging in seabirds and fish, in the water column we find a high biodiversity and activity of zooplankton and larvae such as active light induced synchronized diurnal vertical migration, and at seafloor there is a high biodiversity in benthic animals and macroalgae. The Polar Night is a period for reproduction in many benthic and pelagic taxa, mass occurrence of ghost shrimps (Caprellides), high abundance of Ctenophores, physiological evidence of micro- and macroalgal cells that are ready to utilize the first rays of light when they appear, deep water fishes found at water surface in the Polar night, and continuous growth of bivalves throughout the winter. These findings not only begin to shape a new paradigm for marine winter ecology in the high Arctic, but also provide conclusive evidence for a top-down controlled system in which primary production levels are close to zero. In an era of environmental change that is accelerated at high latitudes, we believe that this new insight is likely to strongly impact how the scientific community views the high latitude marine ecosystem. Despite the overwhelming darkness, the main environmental variable affecting marine organisms in the Polar Night is in fact light. The light regime during the Polar Night is unique with respect to light intensity, spectral composition of light and photoperiod. .

Materialart: Online-Ressource

Seiten: XI, 375 p. 133 illus., 116 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030332082

Serie: Advances in Polar Ecology, 4

URL: https://doi.org/10.1007/978-3-030-33208-2

DOI: 10.1007/978-3-030-33208-2

DDC: 577

Sprache: Englisch

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Long-Term Ecosystem Changes in Riparian Forests (2020)

Sakio, Hitoshi. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Forestry. ; Plant ecology. ; Biotic communities. ; Environment. ; Ecology. ; Forestry. ; Plant Ecology. ; Ecosystems. ; Environmental Sciences.

Beschreibung / Inhaltsverzeichnis: Part I. Introduction -- Chapter 1. The Ooyamazawa Riparian Forest: Introduction and Overview -- Part II. Life History and Regeneration Processes of Riparian Woody Species.-Chapter 2. Fraxinus platypoda -- Chapter 3. Pterocarya rhoifolia -- Chapter 4. Cercidiphyllum japonicum -- Chapter 5. Acer Tree Species -- Part III. Diversity and Coexistence in Riparian Forests -- Chapter 6. Diversity of Herbaceous Plants in the Ooyamazawa Riparian Forest -- Chapter 7. Coexistence of Tree Canopy Species -- Part IV. Ecosystem Changes in Riparian Forests -- Chapter 8. Changes in Forest Floor Vegetation -- Chapter 9. Temporal Changes in Browsing Damage by Sika Deer in a Natural Riparian Forest in Central Japan -- Chapter 10. Characteristics and Temporal Trends of a Ground Beetle (Coleoptera: Carabidae) Community in Ooyamazawa Riparian Forest -- Chapter 11. Avifauna at Ooyamazawa: Decline of Birds that Forage in Bushy Understories -- Part V. Conclusion -- Chapter 12. General Conclusion. .

Kurzfassung: This open access book presents and analyzes the results of more than 30 years of long-term ecological research in riparian forest ecosystems with the aim of casting light on changes in the dynamics of riparian forests over time. The research, focusing on the Ooyamazawa riparian forest, one of the remaining old-growth forests in Japan, has yielded a number of interesting outcomes. First, it shows that large-scale disturbances afford various trees opportunities for regeneration and are thus the driving force for the coexistence of canopy trees in riparian forests. Second, it identifies changes in reproductive patterns, highlighting that seed production has in fact quantitatively increased over the past two decades. Third, it describes the decline in forest floor vegetation caused by deer grazing and reveals how this decline has affected bird and insect populations. The book illustrates the interconnectedness of phenomena within an ecosystem and the resultant potential for cascade effects and also stresses the need for long-term ecological studies of climate change impacts on forests. It will be of interest to both professionals and academics in the field of forest science. .

Materialart: Online-Ressource

Seiten: VIII, 234 p. 173 illus., 65 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811530098

Serie: Ecological Research Monographs,

URL: https://doi.org/10.1007/978-981-15-3009-8

DOI: 10.1007/978-981-15-3009-8

DDC: 577

Sprache: Englisch

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Alpine Plant Life : Functional Plant Ecology of High Mountain Ecosystems (2021)

Körner, Christian.

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Botany. ; Physical geography. ; Conservation biology. ; Ecology. ; Plant Science. ; Earth System Sciences. ; Conservation Biology.

Beschreibung / Inhaltsverzeichnis: PRELIMINARY (ToC of second edition) 1 Plant ecology at high elevations -- The concept of limitation -- A regional and historical account -- The challenge of alpine plant research -- 2 The alpine life zone -- Altitudinal boundaries -- Global alpine land area -- Alpine plant diversity -- Origin of alpine floras -- Alpine growth forms -- 3 Alpine climate -- Which alpine climate -- Common features of alpine climates -- Regional features of alpine climates -- 4 The climate plants experience -- Interactions of relief, wind and sun -- How alpine plants influence their climate -- The geographic variation of alpine climate -- 5 Life under snow: protection and limitation -- Temperatures under snow -- Solar radiation under snow -- Gas concentrations under snow -- Plant responses to snowpack -- 6 Alpine soils -- Physics of alpine soil formation -- The organic compound -- The interaction of organic and inorganic compounds -- 7 Alpine treelines -- About trees and lines -- Current altitudinal positions of climatic treelines -- Treeline-climate relationships -- Intrazonal variations and pantropical plateauing of alpine treelines -- Treelines in the past -- Attempts at a functional explanation of treelines -- A hypothesis for treeline formation -- Growth trends near treelines -- Evidence for sink limitation -- 8 Climatic stress -- Survival of low temperature extremes -- Avoidance and tolerance of low temperature extremes -- Heat stress in alpine plants -- Ultraviolet radiation — a stress factor -- 9 Water relations -- Ecosystem water balance -- Soil moisture at high altitudes -- Plant water relations — a brief review of principles -- Water relations of alpine plants -- Desiccation stress -- Water relations of special plant types -- 10 Mineral nutrition -- Soil nutrients -- The nutrient status of alpine plants -- Nutrient cycling and nutrient budgets -- Nitrogen fixation -- Mycorrhiza -- Responses of vegetation to variable nutrient supply -- 11 Uptake and loss of carbon -- Photosynthetic capacity of alpine plants -- Photosynthetic responses to the environment -- Daily carbon gain of leaves -- The seasonal carbon gain of leaves -- C4 and CAM photosynthesis at high altitudes -- Tissue respiration of alpine plants -- Ecosystem carbon balance -- 12 Carbon investments -- Non-structural carbohydrates -- Lipids and energy content -- Carbon costs of leaves and roots -- Whole plant carbon allocation -- 13 Growth dynamics and phenology -- Seasonal growth -- Diurnal leaf extension -- Rates of plant dry matter accumulation -- Functional duration of leaves and roots -- 14 Cell division and tissue formation -- Cell size and plant size -- Mitosis and the cell cycle -- From meristem activity to growth control -- 15 Plant biomass production -- The structure of alpine plant canopies -- Primary productivity of alpine vegetation -- Plant dry matter pools -- Biomass losses through herbivores -- 16 Plant reproduction -- Flowering and pollination -- Seed development and seed size -- Germination -- Alpine seed banks and natural recruitment -- Clonal propagation -- Alpine plant age -- Community processes -- 17 Global change at high elevation -- Alpine land use -- The impact of altered atmospheric chemistry -- Climatic change and alpine ecosystems -- References (with chapter annotation) -- Taxonomic index (genera) -- Geographical index -- Color plates -- Plant life forms -- The alpine life zone -- Environmental stress -- The human dimension.

Kurzfassung: This book is a completely revised, substantially extended treatment of the physical and biological factors that drive life in high mountains. The book covers the characteristics of alpine plant life, alpine climate and soils, life under snow, stress tolerance, treeline ecology, plant water, carbon, and nutrient relations, plant growth and productivity, developmental processes, and two largely novel chapters on alpine plant reproduction and global change biology. The book explains why the topography driven exposure of plants to dramatic micro-climatic gradients over very short distances causes alpine biodiversity to be particularly robust against climatic change. Geographically, this book draws on examples from all parts of the world, including the tropics. This book is complemented with novel evidence and insight that emerged over the last 17 years of alpine plant research. The number of figures – mostly in color – nearly doubled, with many photographs providing a vivid impression of alpine plant life worldwide. Christian Körner was born in 1949 in Austria, received his academic education at the University of Innsbruck, and was full professor of Botany at the University of Basel from 1989 to 2014. As emeritus Professor he is continuing alpine plant research in the Swiss Alps.

Materialart: Online-Ressource

Seiten: XIX, 500 p. 319 illus., 283 illus. in color. , online resource.

Ausgabe: 3rd ed. 2021.

ISBN: 9783030595388

URL: https://doi.org/10.1007/978-3-030-59538-8

DOI: 10.1007/978-3-030-59538-8

DDC: 577

Sprache: Englisch

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New Nanomaterials and Techniques for Tumor-targeted Systems (2020)

Huang, Rongqin. [editor.] ; Wang, Yi. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Nanotechnology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Nanotechnology. ; Biomedical Research.

Beschreibung / Inhaltsverzeichnis: 1 Introduction -- 2 Barriers for tumor drug delivery -- 3 Tumor-targeted strategies -- 4 Tumor-responsive drug release strategies -- 5 Tumor diagnosis patterns -- 6 Tumor therapeutic modes -- 7 Carbon-based tumor-targeted systems -- 8 Silica-based tumor-targeted systems -- 9 Lipid-based tumor-targeted systems -- 10 Dendrimer-based tumor-targeted systems -- 11 Polymer-based tumor-targeted systems -- 12 Other new tumor-targeted systems -- 13 Clinical applications of tumor-targeted systems -- 14 Challenges and perspectives of tumor-targeted systems.

Kurzfassung: This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.

Materialart: Online-Ressource

Seiten: VI, 463 p. 72 illus., 63 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811551598

URL: https://doi.org/10.1007/978-981-15-5159-8

DOI: 10.1007/978-981-15-5159-8

DDC: 571.978

Sprache: Englisch

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Sunlight, Vitamin D and Skin Cancer (2020)

Reichrath, Jörg. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Dermatology. ; Oncology. ; Cancer Biology. ; Dermatology. ; Oncology.

Beschreibung / Inhaltsverzeichnis: Section I: Introduction -- Lessons learned from paleolithic models and evolution for human health: a snap shot on beneficial effects and risks of solar radiation -- Section II: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences (I) -- Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? -- Section III: Solar radiation, Vitamin D and human health -- Vitamin D status and cancer incidence and mortality -- Vitamin D receptors polymorphisms and cancer -- On the relationship between sun exposure and all-cause mortality -- Lindqvist PG (2020) Women with greater sun exposure habits seem to be healthier and to live longer. Are these results in contrast to other research? No -- Section IV: Epidemiology of skin cancer -- Epidemiology of skin cancer and UV radiation – update 2019 -- Solar UV exposure and mortality from skin tumors: an update -- Solarium Use and Risk for Malignant Melanoma: many open questions,not the time to close the debate -- Section V: Photocarcinogenesis of skin cancer -- Molecular biology of basal and squamous cell carcinomas -- Human papillomaviruses and skin cancer -- The immune system and pathogenesis of melanoma and nonnmelanoma skin cancer -- Section VI: The relevance of the vitamin D endocrine system for skin cancer -- Protection from ultraviolet damage and photocarcinogenesis by vitamin D compounds -- The role of classical and novel forms of vitamin D in the pathogenesis and progression of non-melanoma skin cancers -- The Vitamin D Receptor as tumor suppressor in skin -- Cancer prevention in skin and other tissues via cross-talk between vitamin D- and p53- signalling -- Section VII: Prevention and Management of Skin Cancer -- Sunscreens in the United States: Current Status and Future Outlook -- A handful of sunscreen for whole body application -- Sunlight, vitamin D and Xeroderma pigmentosum -- Update: Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs) -- Section VIII: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences – II. promise and outlook -- Ultraviolet exposure scenarios: balancing risks of erythema and cutaneous vitamin D synthesis -- The Paleolithic nutrition model in relation to ultraviolet light and vitamin D -- Index.

Kurzfassung: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‑exposure to minimize the risks of developing vitamin D deficiency and skin cancer.

Materialart: Online-Ressource

Seiten: XIV, 428 p. 83 illus., 28 illus. in color. , online resource.

Ausgabe: 3rd ed. 2020.

ISBN: 9783030462277

Serie: Advances in Experimental Medicine and Biology, 1268

URL: https://doi.org/10.1007/978-3-030-46227-7

DOI: 10.1007/978-3-030-46227-7

DDC: 571.978

Sprache: Englisch

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Contaminants and Ecological Subsidies : The Land-Water Interface (2020)

Kraus, Johanna M. [editor.] ; Walters, David M. [editor.] ; Mills, Marc A. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Environment. ; Biotic communities. ; Ecology. ; Environmental Sciences. ; Ecosystems.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Introduction: Ecological Subsidies as a Framework for Understanding Contaminant Fate, Exposure, and Effects at the Land-Water Interface -- Part I: Ecological Subsidies Drive Exposure -- Chapter 2: Ecological Factors Controlling Insect-Mediated Methylmercury Flux from Aquatic to Terrestrial Ecosystems: Lessons Learned from Mesocosm and Pond Experiments -- Chapter 3: Pathways of Contaminant Transport Across the Aquatic-Terrestrial Interface: Implications for Terrestrial Consumers, Ecosystems and Management -- Part II: Exposure Drives Ecological Subsidies -- Chapter 4: Agriculture and Mining Contamination Contribute to a Productivity Gradient Driving Cross-Ecosystem Associations between Stream Insects and Riparian Arachnids -- Chapter 5: Cross-Ecosystem Linkages and Trace Metals at the Land-Water Interface -- Chapter 6: Metamorphosis and the Impact of Contaminants on Ecological Subsidies -- Part III: Other Global Stressors -- Chapter 7: Variables Affecting Resource Subsidies from Streams and Rivers to Land and their Susceptibility to Global Change Stressors -- Chapter 8: Beyond “Donors and Recipients”: Impacts of Species Gains and Losses Reverberate among Ecosystems due to Changes in Resource Subsidies -- Part IV: Management Applications and Tools -- Chapter 9: Practical Considerations for the Incorporation of Insect-Mediated Contaminant Flux into Ecological Risk Assessments -- Chapter 10: When Nutrients Become Contaminants in Aquatic Systems: Identifying Responses to Guide Terrestrial-Derived Detrital Endpoint Development for Managers -- Chapter 11: Mesocosms to Evaluate Aquatic-Terrestrial Contaminant Linkages using Aquatic Insect Emergence: Utility for Aquatic Life Criteria Development -- Chapter 12: Studying Effects of Contaminants on Aquatic-Terrestrial Subsidies: Experimental Designs using Outdoor and Indoor Mesocosms and Microcosms -- Part V: Syntheses -- Chapter 13: Ecological Networks as a Framework for Understanding and Predicting Contaminant Movement across the Land-Water Interface -- Chapter: 14: Synthesis: A Framework for Predicting the Dark Side of Ecological Subsidies.

Kurzfassung: This volume explores the effects of aquatic contaminants on ecological subsidies and food web exposure at the boundary of aquatic and terrestrial ecosystems. It provides the first synthesis of the findings and principles governing the “dark side” of contaminant effects on ecological subsidies. Furthermore, the volume provides extensive coverage of the tools being developed to help managers and researchers better understand the implications of contaminants movement and their effects on natural resources and ecosystem processes. Aquatic and terrestrial ecosystems are linked through movements of energy and nutrients which subsidize recipient food webs. As a result, contaminants that concentrate in aquatic systems because of the effects of gravity on water and organic matter have the potential to impact both aquatic and terrestrial ecosystem processes. Within the last decade, increased attention has been paid to this phenomenon, particularly the effects of aquatic contaminants on resource and contaminant export to terrestrial consumers, and the potential implications for management. This volume, curated and edited by three field leaders, incorporates empirical results, management applications and theoretical synthesis and is a key reference for academics, government researchers and consultants.

Materialart: Online-Ressource

Seiten: XV, 383 p. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030494803

URL: https://doi.org/10.1007/978-3-030-49480-3

DOI: 10.1007/978-3-030-49480-3

DDC: 577

Sprache: Englisch

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Cancer Stem Cells: New Horizons in Cancer Therapies (2020)

Pathak, Surajit. [editor.] ; Banerjee, Antara. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Stem cells. ; Oncology. ; Medical microbiology. ; Cancer Biology. ; Stem Cell Biology. ; Oncology. ; Medical Microbiology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to cancer stem cells -- Chapter 2. Types of Cancer Stem Cells -- Chapter 3. Isolation and Characterization of Cancer Stem Cells (CSCs) -- Chapter 4. Lung and Prostate Cancer Stem Cells -- Chapter 5. A differential role of miRNAs in regulation of breast cancer stem cells -- Chapter 6. Skin stem cells in cancer -- Chapter 7. Ocular Cancer stem cells: Advances in therapeutic interventions -- Chapter 8. Cancer Stem Cells and Tumour Aggressiveness -- Chapter 9. Therapeutic Implication of Cancer Stem Cells.-Chapter 10. Glioblastoma stem cells as a therapeutic target -- Chapter 11. Cancer stem cells and therapeutic angiogenesis -- Chapter 12. Cancer stem cells as a seed for cancer metastasis -- Chapter 13. Functionality of intron specific genes and cancer stem cells in the progression of colorectal cancer -- Chapter 14. Technological advancement in Cancer Stem Cell Research -- Chapter 15. Controversies in Isolation and Characterization of Cancer Stem Cells -- Chapter 16. Targeting therapies for cancer stem cells -- Chapter 17. Targeting Cancer stem cells by nanoenabled drug delivery -- Chapter 18. Cancer Stem Cells in Patients Survival and Therapies in Cancer.-.

Kurzfassung: This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.

Materialart: Online-Ressource

Seiten: VII, 369 p. 65 illus., 58 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811551208

URL: https://doi.org/10.1007/978-981-15-5120-8

DOI: 10.1007/978-981-15-5120-8

DDC: 571.978

Sprache: Englisch

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Research Methods of Environmental Physiology in Aquatic Sciences (2021)

Gao, Kunshan. [editor.] ; Hutchins, David A. [editor.] ; Beardall, John. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Water. ; Hydrology. ; Environmental chemistry. ; Environmental sciences. ; Physics. ; Environment. ; Ecology. ; Water. ; Environmental Chemistry. ; Environmental Physics. ; Environmental Sciences.

Beschreibung / Inhaltsverzeichnis: Chapter 1 Measurement of environmental parameters affecting marine plankton physiology -- Chapter 2 Plankton culture techniques -- Chapter 3 Determination of Key Enzymes involved in primary productivity -- Chapter 4 Analyses of pigments -- Chapter 5 Measurements and analyses of photosynthesis and respiration -- Chapter 6 Chlorophyll fluorescence techniques and applications -- Chapter 7 Biochemical and molecular methods -- Chapter 8 Research methods for animal and virus.

Kurzfassung: This book presents methods for investigating the effects of aquatic environmental changes on organisms and the mechanisms involved. It focuses mainly on photosynthetic organisms, but also provides methods for virus, zooplankton and other animal studies. Also including a comprehensive overview of the current methods in the fields of aquatic physiology, ecology, biochemistry and molecular approaches, including the advantages and disadvantages of each method, the book is a valuable guide for young researchers in marine or aquatic sciences studying the physiological processes associated with chemical and physical environmental changes.

Materialart: Online-Ressource

Seiten: XI, 352 p. 83 illus., 23 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9789811553547

URL: https://doi.org/10.1007/978-981-15-5354-7

DOI: 10.1007/978-981-15-5354-7

DDC: 577

Sprache: Englisch

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The Atlantic Forest : History, Biodiversity, Threats and Opportunities of the Mega-diverse Forest (2021)

Marques, Marcia C. M. [editor.] ; Grelle, Carlos E. V. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Botany. ; Zoology. ; Conservation biology. ; Ecology. ; Plant Science. ; Zoology. ; Conservation Biology.

Beschreibung / Inhaltsverzeichnis: Part 1: Historical and biogeographical aspects -- The Atlantic Forest: an introduction to the megadiverse forest of Southern America -- The Atlantic Forest Ecological History: from pre-history to the Anthropocene -- The North-eastern Atlantic Forest: biogeographical, historical and current aspects in the Sugarcane Zone -- The Hileia Baiana - an assessment of natural and historical aspects of the land use and degradation of the central corridor of the Brazilian Atlantic Forest -- The southern Atlantic Forest: Use, degradation, and perspectives for conservation -- Part II – Biodiversity -- Tree diversity in the Brazilian Atlantic Forest: biases and general patterns using different sources of information -- Vascular Epiphytes of the Atlantic Forest: diversity and community ecology -- Social Insects of the Atlantic Forest -- Tetrapod diversity in the Atlantic Forest: maps and gaps -- Freshwater Studies in Atlantic Forest: general overview and prospects -- Part III – Threats -- Land-cover changes and an uncertain future: will the Brazilian Atlantic Forest lose the chance to become a hopespot? -- Climate change and biodiversity in the Atlantic Forest: best climatic models, predicted changes and impacts, and adaptation options -- Non-native species introductions, invasions, and biotic homogenization in the Atlantic Forest -- Causes and consequences of large-scale defaunation in the Atlantic forest -- Pollination systems in the Atlantic Forest: characterization, threats, and opportunities -- IV - Opportunities -- Atlantic Forest: ecosystem services linking people and biodiversity -- Changing the agriculture paradigm in the Brazilian Atlantic Forest: the importance of agroforestry -- Engaging people for large-scale forest restoration: Governance lessons from the Atlantic Forest of Brazil -- The Atlantic Forest Trail: connecting people, biodiversity and protected areas -- Conservation initiatives in the Brazilian Atlantic forest -- Financing conservation in the Brazilian Atlantic Forest -- Integrating researchers for understanding the biodiversity in Atlantic Forest -- The future of the Atlantic Forest.

Kurzfassung: The Atlantic Forest is one of the 36 hotspots for biodiversity conservation worldwide. It is a unique, large biome (more than 3000 km in latitude; 2500 in longitude), marked by high biodiversity, high degree of endemic species and, at the same time, extremely threatened. Approximately 70% of the Brazilian population lives in the area of this biome, which makes the conflict between biodiversity conservation and the sustainability of the human population a relevant issue. This book aims to cover: 1) the historical characterization and geographic variation of the biome; 2) the distribution of the diversity of some relevant taxa; 3) the main threats to biodiversity, and 4) possible opportunities to ensure the biodiversity conservation, and the economic and social sustainability. Also, it is hoped that this book can be useful for those involved in the development of public policies aimed at the conservation of this important global biome.

Materialart: Online-Ressource

Seiten: XXX, 517 p. 66 illus., 44 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030553227

URL: https://doi.org/10.1007/978-3-030-55322-7

DOI: 10.1007/978-3-030-55322-7

DDC: 577

Sprache: Englisch

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Skin Cancer: Pathogenesis and Diagnosis (2021)

Dwivedi, Ashish. [editor.] ; Tripathi, Anurag. [editor.] ; Ray, Ratan Singh. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Biomedical engineering. ; Biochemical markers. ; Nanomedicine. ; Cancers. ; Biomedical Engineering and Bioengineering. ; Biomarkers. ; Cancer Nanotechnology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Cancer of the Skin:Type and Etiology -- Chapter 2. Therapeutic intervention in skin cancer: Future prospects -- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer -- Chapter 4. The Epidemiology of Skin Cancer Worldwide -- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer -- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer -- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy -- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era -- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy -- Chapter 10. Biomedical engineering in cancer diagnosis and therapy -- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology -- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy -- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-.

Kurzfassung: This book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.

Materialart: Online-Ressource

Seiten: VIII, 250 p. 27 illus., 20 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9789811603648

URL: https://doi.org/10.1007/978-981-16-0364-8

DOI: 10.1007/978-981-16-0364-8

DDC: 571.978

Sprache: Englisch

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Genetic Polymorphism and cancer susceptibility (2021)

Sameer, Aga Syed. [editor.] ; Banday, Mujeeb Zafar. [editor.] ; Nissar, Saniya. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Genetics. ; Medical genetics. ; Cancers. ; Genetics and Genomics. ; Medical Genetics. ; Cancer Biology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Polymorphisms and Mutation: What is difference? -- Chapter 2. Single nucleotide polymorphisms and pharmacogenomics -- Chapter 3. Impact of MicroRNA Polymorphisms on Breast Cancer Susceptibility -- Chapter 4. From inflammation to cancer: Role of genetic polymorphisms of Inflammatory Pathway Molecules in Gastric Cancer -- Chapter 5. Colorectal Cancer and genetic polymorphism in key regulatory low penetrance genes -- Chapter 6. Role of Genetic Polymorphisms in Breast Cancer -- Chapter 7. Genetic Polymorphisms of Essential Immune Pathogenic Response Genes and Risk of Cervical Cancer -- Chapter 8. Thyroid Cancer and genetic polymorphism -- Chapter 9. SNPs of TLRs and Bladder Cancer -- Chapter 10. Role of genetic polymorphisms in Lung Cancer.

Kurzfassung: This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.

Materialart: Online-Ressource

Seiten: XXI, 339 p. 48 illus., 46 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9789813366992

URL: https://doi.org/10.1007/978-981-33-6699-2

DOI: 10.1007/978-981-33-6699-2

DDC: 571.978

Sprache: Englisch

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Invasive Species in Forests and Rangelands of the United States : A Comprehensive Science Synthesis for the United States Forest Sector (2021)

Poland, Therese M. [editor.] ; Patel-Weynand, Toral. [editor.] ; Finch, Deborah M. [editor.] ; [weitere]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Environment. ; Ecology . ; Landscape ecology. ; Ecosystems. ; Environmental Sciences. ; Terrestial Ecology. ; Landscape Ecology. ; Ecology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction (Deborah C. Hayes, Becky K. Kerns, Toral Patel-Weynand, and Deborah M. Finch) -- Chapter 2. Impacts of Invasive Species in Terrestrial and Aquatic Systems in the United States (Albert E. Mayfield III, Steven J. Seybold, Wendell R. Haag, M. Tracy Johnson, Becky K. Kerns, John C. Kilgo, Daniel J. Larkin, Rima D. Lucardi, Bruce D. Moltzan, Dean E. Pearson, John D. Rothlisberger, Jeffrey D. Schardt, Michael K. Schwartz, and Michael K. Young) -- Chapter 3. Impacts of Invasive Species on Forest and Grassland Ecosystem Processes in the United States (Chelcy Ford Miniat, Jennifer M. Fraterrigo, Steven T. Brantley, Mac A. Callaham, Jr., Susan Cordell, Jeffrey S. Dukes, Christian P. Giardina, Shibu Jose, and Gary Lovett) -- Chapter 4. Effects of Climate Change on Invasive Species (Deborah M. Finch, Jack L. Butler, Justin B. Runyon, Christopher J. Fettig, Francis F. Kilkenny, Shibu Jose, Susan J. Frankel, Samuel A. Cushman, Richard C. Cobb, Jeffrey S. Dukes, Jeffrey A. Hicke, and Sybill K. Amelon) -- Chapter 5. Invasive Species Response to Natural and Anthropogenic Disturbance (Susan E. Meyer, Mac A. Callaham, Jr., Jane E. Stewart, and Steven D. Warren) -- Chapter 6. Early Intervention Strategies for Invasive Species Management: Connections Between Risk Assessment, Prevention Efforts, Eradication, and Other Rapid Responses (Robert C. Venette, Doria R. Gordon, Jennifer Juzwik, Frank H. Koch, Andrew M. Liebhold, Robert K.D. Peterson, Sharlene E. Sing, and Denys Yemshanov) -- Chapter 7. Management of Landscapes for Established Invasive Species (Therese M. Poland, Jennifer Juzwik, Allen Rowley, Cynthia D. Huebner, John C. Kilgo, Vanessa M. Lopez, Deanna H. Olson, Dean Pearson, Robert Progar, Robert Rabaglia, John D. Rothlisberger, Justin B. Runyon, and Sharlene E. Sing) -- Chapter 8. Restoration of Landscapes and Habitats Affected by Established Invasive Species (Jennifer Koch, Dean E. Pearson, Cynthia D. Huebner, Michael K. Young, and Richard A. Sniezko) -- Chapter 9. Sectoral Impacts of Invasive Species in the United States and Approaches to Management (Anne S. Marsh, Deborah C. Hayes, Patrice N. Klein, Nicole Zimmerman, Alison Dalsimer, Douglas A. Burkett, Cynthia D. Huebner, Robert Rabaglia, Laura A. Meyerson, Bonnie L. Harper-Lore, Jamie L. Davidson, Marla R. Emery, Travis Warziniack, Rebecca Flitcroft, Becky K. Kerns, and Vanessa M. Lopez) -- Chapter 10. Inventory and Monitoring of Invasive Species (Sonja Oswalt, Chris Oswalt, Alycia Crall, Robert Rabaglia, Michael Schwartz, and Becky K. Kerns) -- Chapter 11. Tools and Technologies for Quantifying Spread and Impacts of Invasive Species (Matt Reeves, Inés Ibáñez, Dana Blumenthal, Gang Chen, Qinfeng Guo, Catherine Jarnevich, Jennifer Koch, Frank Sapio, Michael K. Schwartz, Bruce K. Wylie, and Stephen Boyte) -- Chapter 12. Social and Cultural Dynamics of Non-Native Invasive Species (John Schelhas, Janice Alexander, Mark Brunson, Tommy Cabe, Alycia Crall, Michael J. Dockry, Marla R. Emery, Susan J. Frankel, Nina Hapner, Caleb R. Hickman, Rebecca Jordan, Michael J. LaVoie, Zhao Ma, Ross K. Meentemeyer, Joe Starinchak, and Jelena Vukomanovic) -- Chapter 13. The Role of International Cooperation in Invasive Species Research (Andrew Liebhold, Faith Campbell, Doria R. Gordon, Qinfeng Guo, Nathan Havill, Bradley Kinder, Richard MacKenzie, David R. Lance, Dean Pearson, Sharlene E. Sing, Travis Warziniack, Robert C. Venette, and Denys Yemshanov) -- Chapter 14. Economics of Invasive Species (Travis Warziniack, Robert G. Haight, Denys Yemshanov, Jenny L. Apriesnig, Thomas P. Holmes, Amanda M. Countryman, John D. Rothlisberger, and Christopher Haberland) -- Chapter 15. Legislation and Policy (Faith T. Campbell, Hilda Diaz-Soltero, and Deborah C. Hayes) -- Chapter 16. Future Invasive Species Research Challenges and Opportunities (Becky K. Kerns, Therese M. Poland, Robert C. Venette, Toral Patel-Weynand, Deborah M. Finch, Allen Rowley, Deborah C. Hayes, Mike Ielmini) -- APPENDIX 1: Regional Summaries.

Kurzfassung: This open access book describes the serious threat of invasive species to native ecosystems. Invasive species have caused and will continue to cause enormous ecological and economic damage with ever increasing world trade. This multi-disciplinary book, written by over 100 national experts, presents the latest research on a wide range of natural science and social science fields that explore the ecology, impacts, and practical tools for management of invasive species. It covers species of all taxonomic groups from insects and pathogens, to plants, vertebrates, and aquatic organisms that impact a diversity of habitats in forests, rangelands and grasslands of the United States. It is well-illustrated, provides summaries of the most important invasive species and issues impacting all regions of the country, and includes a comprehensive primary reference list for each topic. This scientific synthesis provides the cultural, economic, scientific and social context for addressing environmental challenges posed by invasive species and will be a valuable resource for scholars, policy makers, natural resource managers and practitioners.

Materialart: Online-Ressource

Seiten: XLII, 455 p. 87 illus., 67 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030453671

URL: https://doi.org/10.1007/978-3-030-45367-1

DOI: 10.1007/978-3-030-45367-1

DDC: 577

Sprache: Englisch

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Spatial Modeling and Assessment of Environmental Contaminants : Risk Assessment and Remediation (2021)

Shit, Pravat Kumar. [editor.] ; Adhikary, Partha Pratim. [editor.] ; Sengupta, Debashish. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Environmental monitoring. ; Environmental management. ; Environmental chemistry. ; Pollution. ; Ecosystems. ; Environmental Monitoring. ; Environmental Management. ; Environmental Chemistry. ; Pollution.

Beschreibung / Inhaltsverzeichnis: Part I. Soil and Sediment Contaminants, Risk Assessment and Remediation -- Chapter 1. Introduction to Part I: Soil and Sediment Contaminants, Risk Assessment and Remediation -- Chapter 2. Combating Arsenic Pollution in Soil Environment via Alternate Agricultural Land Use -- Chapter 3. Temporal and Seasonal Variation in Leachate Pollution Index (LPI) in Sanitary Landfill Sites- A Case study of Baidyabati landfill, West Bengal, India -- Chapter 4.Quantification of Landfill Gas Emission and Energy Recovery Potential: A Comparative Assessment of LandGEM and MTM Model for Kolkata -- Chapter 5. Assessment of natural enrichment of heavy minerals along coastal placers of India: Role of lake and river mouth embayment and its implications -- Chapter 6. Assessment the Impact of Plastic Contaminated Fertilizers on Agricultural Soil Health: A Case Study in Memari II C.D.Block, Purba Bardhaman,West Bengal, India -- Chapter 7. Determining the Role of Leaf Relative Water Content and Soil Cation Exchange Capacity in Phytoextraction Process – Using Regression Modelling -- Chapter 8. Phytoremediation of Arsenic using Allium sativum as Model System -- Chapter 9. Spatio-temporal analysis of open waste dumping sites using Google Earth: A case study of Kharagpur City, India -- Part II. Water Contaminants, Risk Assessment and Remediation -- Chapter 10. Introduction to Part II: Water Contaminants, Risk Assessment and Remediation -- Chapter 11. Groundwater Arsenic Contamination Zone based on geospatial modeling, risk and remediation -- Chapter 12. Geospatial assessment of surface water pollution and industrial activities in Ibadan, Nigeria -- Chapter 13. Aquaculture-based water quality assessment and risk remediationalong the Rasulpur River belt, West Bengal -- Chapter 14. Heavy Metal Contamination in Groundwater and Impact on Plant and Human -- Chapter 15. Emerging Threats of Microplastic contaminant in freshwater environment -- Chapter 16. Exploring Particle Size Transport Variability of Suspended Sediments in two Alpine Catchments over the Lesser Himalayan Region, India -- Chapter 17. Salinity and corrosion potential of groundwater in Mewat district of Haryana, India -- Chapter 18. Threats to quality in the coasts of the Black Sea: heavy metal pollution of seawater, sediment, macro-algae and sea-grass -- Chapter 19. Geospatial assessment of groundwater quality for drinking through Water Quality Index and Human Health Risk Index in an upland area of Chotanagpur Plateau of West Bengal, India -- Chapter 20. Existence of Pharmaceuticals and Personal Care Products (PPCPs) in the conventional water treatment process -- Chapter 21. Arsenic-rich surface and groundwater around eastern parts of Rupnagar district, Punjab, India -- Part III. Environmental Contaminants, Impacts and Sustainable Management -- Chapter 22. Introduction to Part III: Environmental Contaminants, Risk Assessment and Remediation -- Chapter 23. Dynamics of ultra-fine particles in indoor and outdoor environments: a modelling approach to study the evolution of particle characteristics -- Chapter 24. Environmental impacts of coal-mining and coal-fired power-plant activities in a developing country with global context -- Chapter 25. Overview of Indoor air pollution: A human health perspective -- Chapter 26. Mineralogy and Morphological characterization of Technogenic Magnetic Particles (TMP) from industrial dust: Insights into environmental implications -- Chapter 27. Pesticides: Recent Updates on Types Toxicity and Bioremediation Strategies -- Chapter 28. Commonly available plant neem (Azadirachtaindica A. Juss) ameliorates dimethoate induced toxicity in climbing perch Anabas testudineus -- Chapter 29. Estimating Particulate Matter concentrations from MODIS AOD considering meteorological parameters using Random Forest Algorithm -- Chapter 30 Bio-monitoring and bioremediation of a trans-boundary river in India: Functional roles of benthic mollusks and fungi -- Chapter 31 Assessing the Maximum Aerobic Biodegradation Potential of Leaf Litter, an Organic Fraction of Municipal Solid Waste, Under Optimum Nutrient Conditions -- Chapter 32. Rising trend of air pollution and its decadal consequences on meteorology and thermal comfort over Gangetic West Bengal, India.

Kurzfassung: This book demonstrates the measurement, monitoring and mapping of environmental contaminants in soil & sediment, surface & groundwater and atmosphere. This book explores state-of-art techniques based on methodological and modeling in modern geospatial techniques specifically focusing on the recent trends in data mining techniques and robust modeling. It also presents modifications of and improvements to existing control technologies for remediation of environmental contaminants. In addition, it includes three separate sections on contaminants, risk assessment and remediation of different existing and emerging pollutants. It covers major topics such as: Radioactive Wastes, Solid and Hazardous Wastes, Heavy Metal Contaminants, Arsenic Contaminants, Microplastic Pollution, Microbiology of Soil and Sediments, Soil Salinity and Sodicity, Aquatic Ecotoxicity Assessment, Fluoride Contamination, Hydrochemistry, Geochemistry, Indoor Pollution and Human Health aspects. The content of this book will be of interest to researchers, professionals, and policymakers whose work involves environmental contaminants and related solutions.

Materialart: Online-Ressource

Seiten: XX, 720 p. 225 illus., 185 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030634223

Serie: Environmental Challenges and Solutions,

URL: https://doi.org/10.1007/978-3-030-63422-3

DOI: 10.1007/978-3-030-63422-3

DDC: 577

Sprache: Englisch

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Fire Ecology and Management: Past, Present, and Future of US Forested Ecosystems (2021)

Greenberg, Cathryn H. [editor.] ; Collins, Beverly. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Forestry. ; Physical geography. ; Applied ecology. ; Ecology . ; Ecosystems. ; Forestry. ; Earth System Sciences. ; Applied Ecology. ; Terrestial Ecology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to Fire Ecology across USA Forested Ecosystems: Past, Present, and Future (Cathryn H. Greenberg, Beverly S. Collins, Scott Goodrick, Michael C. Stambaugh, and Gary R. Wein) -- Chapter 2. The Role of Fire in the Dynamics of Piedmont Vegetation (Joanna Spooner, Robert K. Peet, Michael P. Schafale, Alan S. Weakley and Thomas R. Wentworth) -- Chapter 3. Fire Ecology and Fire Management of Southeastern Coastal Plain Pine Ecosystems (Jeff S. Glitzenstein, J. Stephen Brewer, Ronald. E. Masters, J. Morgan Varner, and J. Kevin Hiers) -- Chapter 4. Fire Ecology and Management in Eastern Broadleaf and Appalachian Forests (Mary A. Arthur, J. Morgan Varner, Charles W. Lafon, Heather D. Alexander, Daniel C. Dey, Craig A. Harper, Sally P. Horn, Todd F. Hutchinson, Tara L. Keyser, Marcus A. Lashley, Christopher E. Moorman, and Callie J. Schweitzer) -- Chapter 5. Fire Ecology and Management of Forest Ecosystems in the Western Central Hardwoods and Prairie-Forest Border (Michael C. Stambaugh, Benjamin O. Knapp, and Daniel C. Dey) -- Chapter 6. Fire in Floodplain Forests of the Southeastern USA hy (Paul R. Gagnon, Loretta L. Battaglia, Brice B. Hanberry, William H. Conner, and Sammy L. King) -- Chapter 7. History and Future of Fire in Hardwood and Conifer Forests of the Great Lakes-Northeastern Forest Region, USA(Lee E. Frelich, Craig G. Lorimer, and Michael C. Stambaugh) -- Chapter 8. Fire Ecology of Rocky Mountain Forests(Sharon M. Hood, Brian J. Harvey, Paula J. Fornwalt, Cameron E. Naficy, Winslow D. Hansen, Kimberley T. Davis, Mike A. Battaglia, Camille Stevens-Rumann, Victoria Saab) -- Chapter 9. Fire Ecology of the North American Mediterranean-Climate Zone(Hugh D. Safford, Ramona J. Butz, Gabrielle N. Bohlman, Michelle Coppoletta, Becky L. Estes, Shana E. Gross, Kyle E. Merriam, Marc D. Meyer, Nicole A. Molinari, and Amarina Wuenschel) -- Chapter 10. Fire Ecology and Management in Pacific Northwest Forests(Matthew J. Reilly, Jessica E. Halofsky, Meg A. Krawchuk, Daniel C. Donato, Paul F. Hessburg, James Johnston, Andrew Merschel, Mark E. Swanson, Joshua S. Halofsky, and Thomas A. Spies) -- Chapter 11. Fire Ecology and Management of Southwestern Forests(Peter Z. Fulé, Catrin M. Edgeley, Carol L. Chambers, Serra Hoagland, Blanca Céspedes) -- Chapter 12. Fire and Forests in the 21st Century: Managing Resilience under Changing Climates and Fire Regimes in USA Forests(James M. Vose, David L. Peterson, Christopher J. Fettig, Jessica E. Halofsky, J. Kevin Hiers, Robert E. Keane, Rachel Loehman, and Michael C. Stambaugh).

Kurzfassung: This edited volume presents original scientific research and knowledge synthesis covering the past, present, and potential future fire ecology of major US forest types, with implications for forest management in a changing climate. The editors and authors highlight broad patterns among ecoregions and forest types, as well as detailed information for individual ecoregions, for fire frequencies and severities, fire effects on tree mortality and regeneration, and levels of fire-dependency by plant and animal communities. The foreword addresses emerging ecological and fire management challenges for forests, in relation to sustainable development goals as highlighted in recent government reports. An introductory chapter highlights patterns of variation in frequencies, severities, scales, and spatial patterns of fire across ecoregions and among forested ecosystems across the US in relation to climate, fuels, topography and soils, ignition sources (lightning or anthropogenic), and vegetation. Separate chapters by respected experts delve into the fire ecology of major forest types within US ecoregions, with a focus on the level of plant and animal fire-dependency, and the role of fire in maintaining forest composition and structure. The regional chapters also include discussion of historic natural (lightning-ignited) and anthropogenic (Native American; settlers) fire regimes, current fire regimes as influenced by recent decades of fire suppression and land use history, and fire management in relation to ecosystem integrity and restoration, wildfire threat, and climate change. The summary chapter combines the major points of each chapter, in a synthesis of US-wide fire ecology and forest management into the future. This book provides current, organized, readily accessible information for the conservation community, land managers, scientists, students and educators, and others interested in how fire behaviour and effects on structure and composition differ among ecoregions and forest types, and what that means for forest management today and in the future. .

Materialart: Online-Ressource

Seiten: XVII, 502 p. 71 illus., 65 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030732677

Serie: Managing Forest Ecosystems, 39

URL: https://doi.org/10.1007/978-3-030-73267-7

DOI: 10.1007/978-3-030-73267-7

DDC: 577

Sprache: Englisch

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Circulating Tumor Cells : Advances in Liquid Biopsy Technologies (2023)

Cote, Richard J. [editor.] ; Lianidou, Evi. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.

Beschreibung / Inhaltsverzeichnis: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.

Kurzfassung: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).

Materialart: Online-Ressource

Seiten: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.

Ausgabe: 2nd ed. 2023.

ISBN: 9783031229039

Serie: Current Cancer Research,

URL: https://doi.org/10.1007/978-3-031-22903-9

DOI: 10.1007/978-3-031-22903-9

DDC: 571.978

Sprache: Englisch

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Immuno-Oncology Crosstalk and Metabolism (2022)

Macha, Muzafar Ahmad. [editor.] ; Bhat, Ajaz Ahmad. [editor.] ; Wani, Nissar Ahmad. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Tumors Immunological aspects. ; Cancer Treatment. ; Biochemistry. ; Metabolism. ; Cell biology. ; Immunology. ; Cancer Biology. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Therapy. ; Metabolic Pathways. ; Immunology.

Beschreibung / Inhaltsverzeichnis: 1 Cancer Metabolism and Aggressive Tumor Behaviour -- 2 Immune Cell Metabolism and Function -- 3 Cancer Cell Metabolism Effecting Immune function -- 4 Immune Cell Metabolites as Fuel for Cancer Cells -- 5 Immuno-Onco metabolism and Resistance to Therapy -- 6 Targeting Immuno-Onco metaolism in Cancers -- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.

Kurzfassung: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.

Materialart: Online-Ressource

Seiten: X, 218 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9789811662263

URL: https://doi.org/10.1007/978-981-16-6226-3

DOI: 10.1007/978-981-16-6226-3

DDC: 571.978

Sprache: Englisch

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Dietary Research and Cancer (2021)

Gacche, Rajesh N.

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Biology. ; Cancer Treatment. ; Biotechnology. ; Molecular biology. ; Physiology. ; Cancer Biology. ; Biological Sciences. ; Cancer Therapy. ; Biotechnology. ; Molecular Biology. ; Physiology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to Dietary Research and Cancer -- Chapter 2. Healthy Dietary Patterns and Cancer -- Chapter 3. Frequently Asked Diet and Nutrition Related Questions by Cancer Survivors -- Chapter 4. Dietary Recommendations of Worldwide Cancer Related Organizations -- Chapter 5. Outcome of ‘Diet and Cancer’ Related Clinical Trials -- 6. Diet and Cancer Epigenetics: A Step Towards Developing Cancer Epigenetic Diet -- 7. Role of Dietary Ingredients on Expression of Oncogenic and Tumor Suppressor miRNA -- 8. Can Diet Influence Metastasis? -- 9. Impact of Dietary Interventions on Cancer Stem Cells -- 10. Interaction of Dietary Metabolites with Anti-cancer Drug Targets -- 11. Revisiting the Anticancer Drug-Food Interactions -- 12. Functional Foods, Nutraceuticals, and Dietary Supplements in Cancer Prevention -- 13. Do Antioxidants Really Help Cancer Patients? The Puzzle of Benefits and Perils -- 14. Market of Dietary Supplements: Analysis of Health Benefits and Risk in Cancer -- 15. Cancer and Fasting: Can Fasting/Calorie Restriction (CR) or Fasting Mimicking Diet (FMD) Helps Fight Cancer? Molecular Basis of Fasting Response -- 16. Do Fasting, CR, and FMD Improves the Chemotherapy Response, Reduce Off Target Toxicities and Enhance Antitumor Immunity? Illusion or Clinical Reality? -- 17. Future Prospectus of Dietary Interventions in the Integrated Management of Cancer.

Kurzfassung: This book reviews all important aspects of dietary research associated with cancer with the aim of shedding new light on these conditions through combined understanding of traditional and new paradigms. The book is divided into 17 chapters, the first portion reinterprets healthy diets for cancer based on up-to-date evidence from a network science perspective, examining the dietary patterns, outcome of diet related clinical trials, emerging framework of molecular mechanisms and interactions of dietary interventions and their applications in personalized diet, ground realities of benefits and regulatory frame work for functional foods, nutraceuticals and supplements in cancer prevention and upcoming future prospectus in diet-cancer research.. The later part of the book discusses recent advances in understanding of the elaborative discourse on cancer and fasting, covering, for example, calorie restriction and fasting mimicking diet. Finally, different Dietary research and approaches are considered in the context of novel intervention for cancer research. Dietary Research in Cancer will be of interest for all researchers, nutritionists, students and clinicians in the field.

Materialart: Online-Ressource

Seiten: XX, 197 p. 57 illus., 16 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9789811660504

URL: https://doi.org/10.1007/978-981-16-6050-4

DOI: 10.1007/978-981-16-6050-4

DDC: 571.978

Sprache: Englisch

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Hidden Pathways to Extinction (2022)

Strona, Giovanni.

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Parasitology. ; Conservation biology. ; Environment. ; Applied ecology. ; Ecology. ; Parasitology. ; Conservation Biology. ; Conservation Biology. ; Environmental Sciences. ; Applied Ecology.

Kurzfassung: This book provides, for the first time, a comprehensive overview of the fundamental roles that ecological interactions play in extinction processes, bringing to light an underground of hidden pathways leading to the same dark place: biodiversity loss. We are in the midst of the sixth mass extinction. We see species declining and vanishing one after another. Poached rhinos, dolphins and whales slaughtered, pandas surviving only in captivity are strong emotional testimonials of what is happening. Yet, the main threat to natural communities may be overshadowed by the disappearance of large species, with most extinctions happening unnoticed and involving less eye-catching organisms, such as parasites and pollinators. Ecosystems hide countless, invisible wires connecting organisms in dense networks of ecological interactions. Through these networks, perturbations can propagate from one species to another, producing unpredictable effects. In worst case scenarios, the loss of one species might doom many others to extinction. Ecologists now consider such mechanisms as a fundamental – and still poorly understood - driver of the ongoing biodiversity crisis. Hidden Pathways to Extinction makes the invisible links connecting the fates of species and organisms evident, exploring why complexity can enhance ecosystem stability and yet accelerate species loss. Page after page, Strona provides convincing evidence that we are primarily responsible for the fall in biodiversity, that we are falling too, and that we need to redouble our conservation efforts now, or it won't be long before we hit the ground.

Materialart: Online-Ressource

Seiten: IX, 237 p. 88 illus., 51 illus. in color. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783030867645

Serie: Fascinating Life Sciences,

URL: https://doi.org/10.1007/978-3-030-86764-5

DOI: 10.1007/978-3-030-86764-5

DDC: 577

Sprache: Englisch

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Blue-Green Infrastructure Across Asian Countries : Improving Urban Resilience and Sustainability (2022)

Dhyani, Shalini. [editor.] ; Basu, Mrittika. [editor.] ; Santhanam, Harini. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Urban ecology (Biology). ; Biotic communities. ; Population biology. ; Ecology Methodology. ; Ecology. ; Urban Ecology. ; Community and Population Ecology. ; Ecological Modelling.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Mainstreaming Blue-Green Infrastructure for improving urban resilience and sustainability in the warming world -- Chapter 2. Regional trends in Social-Ecological Technological (SET) approaches to Sustainable Urban Planning: Focus on Asia -- Chapter 3. A Risk Assessment Approach to Urban Resilience -- Chapter 4. Promoting Blue Green Infrastructure in Urban Spaces through Citizen Science initiatives -- Chapter 5. Is Ensuring the Sustainable Implementation of BGI Possible? System Thinking of Urban Rivers as Social-Ecological Systems -- Chapter 6. Understanding Blue-Green Infrastructure through Spatial Maps: Contribution of Remote Sensing and GIS Technology -- Chapter 7. Cities and Biodiversity: Hidden Connections Between the Built Form and Life -- Chapter 8. Assessing ecological risks of urban air and water environment to analyse the scenarios for mainstreaming Nature-based Solutions: a case study of Bengaluru city, India -- Chapter 9. Do people appreciate economic value of water in Baku city of Azerbaijan? -- Chapter 10. Homegardens as sustainable urban agroforestry systems to promote household well-being in Kandy, Sri Lanka -- Chapter 11. Opportunities for Improving Urban Tree Cover - A Case Study in Kochi -- Chapter 12. Changing people-nature linkages around green infrastructure in rapidly urbanizing landscapes: the case of a protected area in Bengaluru Metropolitan Region of South India -- Chapter 13. Remodelling Urban Spaces in the Light of Blue-Green Infrastructure: A Case Study of Guwahati, India -- Chapter 14. Nature-based Solutions for the Restoration of the Abukuma River Ba-sin (Japan) after Typhoon Hagibis -- Chapter 15. Nature based solutions (NbS) for sustainable development of the resource-base and ecosystem services of marine and coastal ecosystems of India -- Chapter 16. Physical Vulnerability Assessment to Flooding of Residential Houses along the Coastal Areas in Sta. Rosa City, Laguna, Philippines -- Chapter 17. The significance of ancient water systems and the sacred groves in the landscape of Badami, Karnataka - A geospatial study -- Chapter 18. Urban Sustainability and Resilience building: Blue-Green infrastructure for air pollution abatement and realising multiple co-benefits -- Chapter 19. Disaster Risks and Resilience of Urban Bangladesh: Role of Blue Green Infrastructure -- Chapter 20. Endorsing City Biodiversity Index (CBI): Assessing Ecosystem Health in urban sprawls and Eco-DRR inclusive urban planning -- Chapter 21. Greenhouse Gas Mitigation by Integrating Waste Treatment System towards Low-Carbon City in Vietnam -- Chapter 22. The roles of non-governmental actors in facilitating urban blue-green infrastructures: A comparative review of the community initiatives in Taipei City, Taiwan -- Chapter 23. Mainstreaming blue-green infrastructure in policy and planning for urban resilience in the global south: promises and pitfalls.

Kurzfassung: This edited book discusses Blue-Green Infrastructure (BGI) from conception to implementation in building resilience and urban sustainability. The book emphasizes on infrastructures, institutions, and perceptions as three main pillars of implementing and managing successful BGI, with a special focus on Asia. The book highlights concepts as well as field-based experiences from different parts of Asia by experts, with a special focus on advances and opportunities in advancing BGI, challenges and constraints, followed by case studies on BGI mainstreaming. It addresses sustainable water management, multiscale environmental design, environmental risk assessment, and finally understanding policy implications and concerns for BGI mainstreaming in growing urban sprawls of the region. There has been growing global momentum and recognition of Blue-Green Infrastructure (BGI) as a multifunctional Nature-based Solution (NbS) with multiple co-benefits. There is strong evidence from many urban centres of Europe, USA, China, and South Africa demonstrating that mainstreaming BGI can help in addressing growing vulnerability of urban areas by ensuring safety, resilience, and sustainability for urban residents in the warming world. This book is a timely contribution for researchers, students, scholars, urban planners, consultants, and policy makers in the fields of environment, resilience, urban planning, climate adaptation, and sustainability science. .

Materialart: Online-Ressource

Seiten: XXI, 518 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9789811671289

URL: https://doi.org/10.1007/978-981-16-7128-9

DOI: 10.1007/978-981-16-7128-9

DDC: 577

Sprache: Englisch

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Satoumi Science : Co-creating Social-Ecological Harmony Between Human and the Sea (2022)

Kakuma, Shinichiro. [editor.] ; Yanagi, Tetsuo. [editor.] ; Sato, Tetsu. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Environmental management. ; Oceanography. ; Sustainability. ; Biotic communities. ; Ecology. ; Environmental Management. ; Ocean Sciences. ; Sustainability. ; Ecosystems.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Prologue: What is Satoumi? -- Chapter 2. The History and Future of Satoumi Concept -- Chapter 3.Global Effect of the Satoumi Concept – Harmony of Human Society with the Ocean Biome -- Chapter 4. Roles of Women in Satoumi -- Chapter 5. Enlivening Ecosystems with Human Hands: Building Satoumi through Coral Reef Culture -- Chapter 6. Restoring Eelgrass Beds and Culturing Oysters -- Chapter 7. Reviving Abandoned Aquaculture Ponds and Coastal Areas by Integrated Multi Tropic Aquaculture -- Chapter 8. Conserving Multiple Coral Reef Resources -- Chapter 9. Villagers Managing Lake Fisheries Resources by Themselves: Mbenji Islands in Lake Malawi -- Chapter 10. Protecting Fisheries Resources through Marine Protected Area Networks – Fiji -- Chapter 11. Connecting Local Regions and Cities through Mozuku Seaweed Farming and Coral Reef Restoration: Onna Village, Okinawa -- Chapter 12. Divers and Fishermen Working Together to Create Satoumi -- Chapter 13. Models for Implementing the Satoumi Concept via Residential Research Institute Collaborations with Citizen Scientists in the United States -- Chapter 14. Epilogue: Opening the Way to Sustainable Futures with Satoumi.

Kurzfassung: This book guides readers to the new concept of “Satoumi” and explains how its practice works to solve challenges in complex social-ecological systems of coastal areas. The book describes the significance of Satoumi Science as a transdisciplinary process. It starts with introducing the definition of Satoumi, highlights the important distinction between active measures (direct actions to improve ecosystem functions and services) and passive measures (a variety of management activities), and presents the concept of Integrated Local Environmental Knowledge (ILEK) as a knowledge base for Satoumi activities. It also introduces residential researchers and bilateral knowledge translators as the key actors of Satoumi co-creation through the transdisciplinary processes. The concept of Satoumi goes beyond the idea of protecting pristine nature by eliminating humans. It is about creating coastal environments where humans closely connect with the sea, which leads to the effective conservation and sustainable management of various natural resources and ecosystem services. This book will be of high interest to managers, governments, environmental groups, and the research community. Chapters cover current and emerging concerns, such as over- and under-use of natural resources, restoration of damaged ecosystems, and co-creation of new relations between humans and coastal seas, from transdisciplinary approaches to tackle with complex and 'wicked' challenges of coastal social-ecological systems. .

Materialart: Online-Ressource

Seiten: VIII, 272 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9789811674914

Serie: Ecological Research Monographs,

URL: https://doi.org/10.1007/978-981-16-7491-4

DOI: 10.1007/978-981-16-7491-4

DDC: 577

Sprache: Englisch

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Psammic Peinobiomes : Nutrient-Limited Ecosystems of the Upper Orinoco and Rio Negro Basins (2023)

Zinck, Joseph Alfred. [editor.] ; Huber, Otto. [editor.] ; García Montero, Pedro. [editor.] ; [weitere]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Soil science. ; Plant ecology. ; Geomorphology. ; Ecophysiology. ; Conservation biology. ; Ecology . ; Ecosystems. ; Soil Science. ; Plant Ecology. ; Geomorphology. ; Ecophysiology. ; Conservation Biology.

Beschreibung / Inhaltsverzeichnis: 1 Introduction -- Part I: Forest and woodland biomes -- 2 White sand ecosystems in the Amazon basin: geographic distribution, distinctive features, and ecology. An overview -- 3 The forests of the Rio Negro basin in the north-western Amazon: a phytosociological classification -- 4 Amazon caatinga complex: sclerophyllous vegetation on nutrient-poor white sand soils -- Part II: Meadow biomes -- 5 Mapping white-sand ecosystems by integrating Global PALSAR-2 and SENTINEL-1 with NDVI (LANDSAT data) -- 6 The study areas: landscapes and soils -- 7 Soil properties, formation, distribution, and classification -- 8 Origin and sources of sand: from highlands to lowlands -- 9 Sand dynamics and distribution: a geo-sedimentological approach -- 10 Features and trends of meadow landscape evolution -- 11 Meadow phytodiversity: flora, endemism, vegetation types, and geographic distribution patterns -- 12 Synthesis: white-sand and meadow-vegetation relationships.

Kurzfassung: The book represents a multidisciplinary approach to understanding soil–landscape–vegetation relationships and, specifically, the ecophysiology of plant communities developing on sandy soils of very low fertility that are subject to seasonal flooding. It provides an overview of the white sand ecosystems within the Amazon basin, and focuses on the forest and herbaceous (meadows) vegetation growing on the dystrophic sandy soils of the upper Negro and Orinoco river basins. Several chapters describe physiographic aspects of the study area using integrated remote sensing and in situ sampling. By doing so they attain a comprehensive description of the origin and evolution of soils and landscapes, an advanced classification of soils, and a mapping of the geographic distribution of psammophilous vegetation. This volume also provides a phytosociological classification of extensive forested areas, and a detailed description of the structure and diversity of little-known herbaceous formations. It targets professionals in the fields of ecology, ecophysiology, geomorphology, soils, vegetation, and the environmental sciences. The information it offers may be of significant use to researchers, protected area planners, and environmental policy makers.

Materialart: Online-Ressource

Seiten: XIV, 541 p. 136 illus., 122 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031207990

Serie: Ecological Studies, Analysis and Synthesis, 247

URL: https://doi.org/10.1007/978-3-031-20799-0

DOI: 10.1007/978-3-031-20799-0

DDC: 577

Sprache: Englisch

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Civil Society and Peacebuilding in Sub-Saharan Africa in the Anthropocene : An Overview (2022)

Kiyala, Jean Chrysostome K. [editor.] ; Harris, Geoff Thomas. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Sustainability. ; Environmental sciences Social aspects. ; Ecology. ; Sustainability. ; Environmental Social Sciences.

Beschreibung / Inhaltsverzeichnis: 1 General Introduction -- 2 Peace Ecology in the Anthropocene for Africa -- 3 Civil Society, Climate Change, Security Risks Management and Peacebuilding in the Anthropocene -- 4 Faith-based Organisations and Environmental Peace: Impact of Laudato Si’ and Its Relevance in the Anthropocene -- 5 Healing Nature and Creation in the Anthropocene: A Reflection on the Role of Religion -- 6 Empowering Women to Build Peace: A Case Study of Grace to Heal Trust in Lupane District -- 7 Peacebuilding through Indigenous Knowledge Systems: Lessons from Civil Society Organisations in Zimbabwe -- 8 Civil Society and Peacebuilding in the Kivu Provinces of the Democratic Republic of Congo -- 9 Zimbabwe’s National Peace and Reconciliation Commission and Civil Society: Partners in Peacebuilding? -- 10 Civil Society and Peacebuilding in the Democratic Republic of Congo: Opportunities, Challenges and Recommendations -- 11 Promoting Democratisation in DR Congo: The Case Study of Act for Transparent and Peaceful Elections -- 12 Civil Society Organisations and School Peace Clubs in South Africa: An Outcome Evaluation -- 13 The Challenges and Opportunities for Civil Society in Peacebuilding: Lessons from the Matabeleland Collective, Zimbabwe -- 14 The Role of Civil Society Participation in Social Cohesion Processes in KwaZulu-Natal, South Africa.-15 Building the Capacity of Civil Society Organisations in Nonviolent Campaigning: A Case Study from South Sudan -- 16 How Informal Peace Committees Complement Macro-infrastructures for Peace in Zimbabwe -- 17 Protecting and Nurturing Children Born from Rape in South Kivu Communities: A Challenge for Civil Society -- 18 Indigenous Peacebuilding Approaches and the Accountability of Former Child Soldiers: African Case Studies -- 19 Navigating Channels for Civil Society Participation in Conflict Prevention and Peace-Making in the African Peace & Security Architecture -- 20 Centre-periphery Relations Between Civil Society Organisations and External Funding Partners: A Case Study of South Kivu’s Peace and Development Agenda. .

Kurzfassung: This book examines civil society's peacebuilding role in sub-Saharan Africa in the context of climate change and the pursuit of environmental peace and justice in the Anthropocene. Five main research themes emerge from its 20 chapters: · The roles of environmental peacemaking, environmental justice, ecological education and eco-ethics in helping to mitigate the impacts of climate change · Peacebuilding by CSOs after violent conflicts, with particular reference to accountability, reconciliation and healing · CSO involvement in democratic processes and political transition after violent conflicts · Relationships between local CSOs and their foreign funders and the interactions between CSOs and the African Union's peace and security architecture. · The particular role of faith-based CSOs The book underlines the centrality of dialogue to African peacebuilding and the indigenous wisdom and philosophies on which it is based. Such wisdom will be a key resource in confronting the existential challenges of the Anthropocene. The book will be a significant resource for researchers, academics and policymakers concerned with the challenge of climate change, its interactions with armed conflict and the peacebuilding role of CSOs. · This pathbreaking book shows why peacebuilding analysis and efforts need to be urgently re-oriented towards the existential challenges of environmental peace and justice. · It explains the emerging conceptual frameworks which are needed for this new role. · It explains the critical role that CSOs - local and international - will play in implementing this new peacebuilding approach, with particular reference to sub- Saharan Africa.

Materialart: Online-Ressource

Seiten: XXXVI, 580 p. 43 illus., 40 illus. in color. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783030951795

Serie: The Anthropocene: Politik—Economics—Society—Science, 34

URL: https://doi.org/10.1007/978-3-030-95179-5

DOI: 10.1007/978-3-030-95179-5

DDC: 577

Sprache: Englisch

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Disturbance Ecology (2022)

Wohlgemuth, Thomas. [editor.] ; Jentsch, Anke. [editor.] ; Seidl, Rupert. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Landscape ecology. ; Plant ecology. ; Ecology. ; Landscape Ecology. ; Plant Ecology. ; Terrestial Ecology.

Beschreibung / Inhaltsverzeichnis: Chap 1: Disturbance ecology: a guideline -- Chap 2: Definitions and quantifications -- Chap 3: Concepts -- Chap 4: Abiotic disturbances -- Chap 5: Biotic disturbances -- Chap 6: Anthropogenic disturbances -- Chap 7: Disturbances in global change -- Chap 8: Disturbances and management.

Kurzfassung: This edited work presents a multi-faceted view on the causes and consequences of disturbance in ecosystems. Vegetation can be affected by a variety of different disturbances such as wind, floods, fire, and insect attack, leading to an abrupt change in live biomass. Disturbance is a motor of vegetation dynamics, but also sensitive to climate change and poses a challenge for ecosystem management. Readers will discover the global distribution of disturbance regimes and learn about the importance of disturbances for biodiversity and the evolution of plant and animal life. The book provides a Central European perspective on disturbance ecology, and addresses important disturbance agents such as fire, wind, avalanches, tree diseases, insect defoliators, bark beetles and large herbivores in dedicated chapters. It furthermore includes chapters on anthropogenic disturbances in forests and grasslands. The impact of climate change on disturbance regimes and approaches to address disturbance risks in ecosystem management are discussed in concluding chapters. Within the 18 chapters 14 textboxes highlight current topics of disturbance ecology and provide deeper methodological insights into the field. Disturbances strongly shape our landscapes and maintain our biodiversity. A better understanding of their ecology is thus fundamental for contextualizing the dynamic changes in our environment. This book is a valuable resource for students and practitioners interested in disturbances and their management.

Materialart: Online-Ressource

Seiten: XI, 439 p. 153 illus. in color. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783030987565

Serie: Landscape Series, 32

URL: https://doi.org/10.1007/978-3-030-98756-5

DOI: 10.1007/978-3-030-98756-5

DDC: 577

Sprache: Englisch

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Sustainable Utilization and Conservation of Africa’s Biological Resources and Environment (2023)

Izah, Sylvester Chibueze. [editor.] ; Ogwu, Matthew Chidozie. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Biodiversity. ; Biotic communities. ; Population biology. ; Agricultural ecology. ; Ecology. ; Biodiversity. ; Community and Population Ecology. ; Agroecology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Overview of African Biological Resources and Environment -- Chapter 2. Biodiversity Conservation and Tourism Sustainability in Africa -- Chapter 3. Biodiversity Conservation Strategies and Sustainability -- Chapter 4. Potentials, threats, and sustainable conservation strategies of Plankton and Macrophytes -- Chapter 5. Threats and conservation status of cercopithecus sclateri in Akwa Ibom State, Nigeria -- Chapter 6. Potential threats and possible conservation strategies of Biodiversity in Niger Delta region of Nigeria -- Chapter 7. Exploration of Local Beliefs and Cultural Heritages as Tools for Species Conservation in Selected Sites in Africa -- Chapter 8. The need to conserve and protect forest resources -- Chapter 9. Rationale behind conservation of Africa’s biological resources -- Chapter 10. The Value of Biodiversity to Sustainable Development in Africa -- Chapter 11. Medicinal potentials of Aloe vera (Aloe barbadensis Miller): Technologies for the production of Therapeutics -- Chapter 12. Sustainable utilization of important medicinal plants in Africa -- Chapter 13. Local Food Crops In Africa: Sustainable Utilization, Threats, And Traditional Storage Strategies -- Chapter 14. Environmental Pollution: Threats, Impact on Biodiversity, and Protection Strategies -- Chapter 15. Environmental Degradation in the Niger Delta Ecosystem: the role of Anthropogenic pollution -- Chapter 16. Climate Change and Other Environmental Factors as Drivers of Fauna and Flora Biodiversity in Africa -- Chapter 17. Contamination of African water resources: impacts on biodiversity and strategies for conservation and restoration -- Chapter 18. Disease Outbreaks In Ex-Situ Plant Conservation And Potential Management Strategies -- Chapter 19. Challenges of sea turtle conservation in African territorial waters: the way out -- Chapter 20. An Overview of Environmental Resources in Africa: Emerging Issues and Sustainable Exploitation -- Chapter 21. Touristic Value of African Environment: A Socio-Economic Perspective. Chapter 22. Environmental Sustainability: Relevance of Forensic Insects and other Ecosystem Services in Africa -- Chapter 23. Intrinsic Values of the African Environment: A Sustainable Perspective -- Chapter 24. Towards sustainable biological and environmental policies in Africa.

Kurzfassung: This edited book highlights the potential and actual contributions of the sustainable management and utilization of indigenous biological resources and environment for the development of Africa. The book centers on documenting current trends and issues in the field of resource use and conservation with the view of emphasizing their benefits to the pursuit of development within the region. By documenting the array of natural resources and environment in Africa, this book addresses the topical knowledge and understanding gaps that characterize conservation (rationale for sustainable resource exploration), utilization patterns, and conservation challenges including policy status, environmental threats, impacts of tourism, reduction in food resources, etc., and their effects on the sustainable development of Africa. Through an integrated approach, the book focuses on below and above-ground biological resources and the diverse scales of environment that characterize Africa. This collection of works is very helpful for natural and social scientists, policymakers, strategists, researchers, government and non-government organizations, biodiversity and environmental managers, climate change scientists, practitioners, activists, conservationists, academics, ecologists, undergraduate and postgraduate students, and others who want to learn about and understand the best way to use and protect Africa's resources and heritage sustainably.

Materialart: Online-Ressource

Seiten: XV, 691 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811969744

Serie: Sustainable Development and Biodiversity, 32

URL: https://doi.org/10.1007/978-981-19-6974-4

DOI: 10.1007/978-981-19-6974-4

DDC: 577

Sprache: Englisch

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Cancer Neuroscience (2023)

Amit, Moran. [editor.] ; Scheff, Nicole N. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.

Kurzfassung: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.

Materialart: Online-Ressource

Seiten: XII, 202 p. 21 illus., 20 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031324291

URL: https://doi.org/10.1007/978-3-031-32429-1

DOI: 10.1007/978-3-031-32429-1

DDC: 571.978

Sprache: Englisch

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Cancer Metastasis Through the Lymphovascular System (2022)

Leong, Stanley P. [editor.] ; Nathanson, S. David. [editor.] ; Zager, Jonathan S. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Metastasis. ; Lymphatics. ; Cancer Biology. ; Metastasis. ; Lymphatic System.

Beschreibung / Inhaltsverzeichnis: Section 1: Genetic and Molecular Pathways of Cancer Growth and Metastasis -- Chapter 1. Hallmarks of Cancer: Molecular Underpinnings -- Chapter 2. Unifying concept of genomic changes: The mutational landscape of cancers -- Chapter 3. Tumor Microenvironment: Coconspirator in Tumorigenesis -- Chapter 4. Hallmarks of Metastasis: Molecular Underpinnings -- Chapter 5. Hereditary Cancer Syndromes and Cancer Metastasis -- Section 2: Pathology of Cancer Growth and Metastasis -- Chapter 6. Pathologic Assessment of Lymph Node Metastasis -- Chapter 7. Pathologic Assessment of Systemic or Distant Metastasis -- Chapter 8. The Role of Angiotropic Extravascular Migratory Metastasis in Metastases -- Section 3: Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment -- Chapter 9. Tumor Dormancy and Relapse Regulated by the Extracellular Matrix -- Chapter 10. Therapy-Induced Dormancy and Residual Disease -- Section 4: The Microenvironment of Site-Specific Metastasis - Isaac P. Witz -- Chapter 11. The Microenvironment of Site-Specific Metastasis -- Section 5: Circulating Cancer Cells and Liquid Biopsy -- Chapter 12. Circulating tumor cells and ctDNA in sarcomas -- Chapter 13. Liquid biopsy using cell-free tumor DNA for gastrointestinal cancers -- Chapter 14. Circulating tumor cells and ctDNA in prostate cancer.-Chapter 15. Circulating Tumor Cells in Lung Cancer -- Chapter 16. CTCs/ ctDNA and Brain Metastasis.-Chapter 17. Epigenetics and liquid biopsy in oncology: role in metastasis and clinical utility -- Chapter 18. Metabolic reprogramming of circulating tumor cells for metastasis -- Section 6: Lymphatic System and Cancer Metastasis -- Chapter 19. Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis -- Chapter 20. Lymphatic Specification and Development, EMT-MET, and Cancer Spread -- Chapter 21. Lymphangiogenesis, Lymph Nodes, Cancer Lymphangiogenesis and Metastasis -- Chapter 22. Immune cell trafficking in the lymphatics, hyaluronan biology and tumour metastasis -- Chapter 23. Lymphvascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis -- Chapter 24. Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis -- Chapter 25. Lymphedema: general pathophysiology, prevention and management in invasive cancer -- Section 7: Radiological Imaging of Early Cancer and Cancer Metastases -- Chapter 26. Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease -- Chapter 27. Imaging Modalities in the Detection and Diagnosis of Metastatic Disease -- Chapter 28. Imaging of Bone Metastases -- Chapter 29. Imaging of Lung and Soft Tissue Metastases -- Chapter 30. Image-Guided Biopsy and Intervention for Metastatic Disease -- Section 8: Sentinel Lymph Node Surgery for Solid Cancer. Chapter 31. Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy -- Chapter 32. Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 33. Sentinel node navigation surgery for upper gastrointestinal cancer -- Chapter 34. Sentinel Lymph Node Mapping in Non-Small Cell Lung, Colon, and Thyroid Carcinomas -- Section 9: Surgical Treatment of Primary and Metastatic Cancer -- Chapter 35. The efficacy and evolution of surgical management based on cancer biology -- Chapter 36. The role of surgery in managing primary and metastatic melanoma -- Chapter 37. The Role of Surgery in Managing Primary and Metastatic Breast Cancer -- Chapter 38. The role of surgery in managing primary and metastatic colorectal cancer -- Chapter 39. The Role of Surgery in Management of Gastric Cancer -- Chapter 40. The role of surgery in managing primary and metastatic hepatopancreaticobiliary cancers -- Section 10: Cancer Metastasis to the Lung -- Chapter 41. Metastatic disease of the lung -- Section 11: Cancer Metastasis to the Liver -- Chapter 42. Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases -- Chapter 43. Regional Arterial Infusional Therapy as a Means of Controlling Hepatic Metastases -- Section 12: Cancer Metastasis to the Bone -- Chapter 44. Molecular Mechanisms of Metastasis to the Bone.-Chapter 45. Surgical Management of Metastatic Disease to the Upper Extremity -- Chapter 46. Surgical Management of Metastatic Disease to the Lower Extremity -- Chapter 47. Surgical management of metastatic disease to the pelvis -- Chapter 48. Surgical Management of Metastatic Disease to the Spine -- Chapter 49. Interventional radiology techniques for management of skeletal metastases -- Section 13: Cancer Metastasis to the Brain and the Nervous System -- Chapter 50. Brain Metastases: Overview and Molecular Mechanisms -- Chapter 51. Indications and Techniques for Surgical Intervention in Patients with Metastatic Brain Tumors -- Chapter 52. Brain Metastases: Current and Future pharmacological treatment -- Chapter 53. Radiotherapy for CNS Metastases -- Chapter 54. Leptomeningeal Carcinomatoses -- Section 14: Urologic Cancer and 1st Patterns of Metastasis -- Chapter 55. Urologic Cancer and 1st Patterns of Metastasis -- Section 15: Biology and Clinical Aspects of Sarcoma Progression -- Chapter 56. Soft Tissue Sarcoma -- Chapter 57. Bone Sarcoma -- Chapter 58. Liposarcoma Metastasis -- Chapter 59. Desmoid Tumors.-Chapter 60. Atypical patterns of metastases: How do Sarcoma’s metastasize? -- Chapter 61. Tumor Immune Microenvironment of Soft Tissue Sarcoma -- Section 16: The Role of Radiation in the Treatment of Primary and Metastatic Cancer -- Chapter 62. Basic Principles of Radiobiology and Cancer Metastasis Prevention -- Chapter 63. Technical Innovations in the Delivery of Radiation Therapy -- Chapter 64. Radiation Therapy in the Definitive Treatment of Cancer -- Chapter 65. Radiation Therapy for Extracranial Oligometastatic Disease -- Chapter 66. Spine Radiotherapy -- Section 17: Immunotherapy of Solid Malignancies -- Chapter 67. Immunotherapy in Melanoma and Merkel Cell Cancer -- Chapter 68. Landscape of Immunotherapy in Lung Cancer -- Chapter 69. Immuno-oncologic Treatment of Genitourinary Malignancies -- Section 18: Current Topics -- Chapter 70. Personalized Systemic Cancer Therapy -- Chapter 71. Cancer Stem Cells and Their Role in Metastasis -- Chapter 72. HPV Induced Cancers -- Chapter 73. Microbiome and Cancer Metastasis -- Chapter 74. Application of Artificial Intelligence in Research on Cancer and Its Metastasis.

Kurzfassung: This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .

Materialart: Online-Ressource

Seiten: XXIV, 806 p. 145 illus., 106 illus. in color. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783030930844

URL: https://doi.org/10.1007/978-3-030-93084-4

DOI: 10.1007/978-3-030-93084-4

DDC: 571.978

Sprache: Englisch

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Hepatobiliary Cancers: An Interdisciplinary Approach (2023)

Rezaei, Nima. [editor.]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Immunotherapy. ; Cancer Genetic aspects. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Tumour Immunology. ; Immunotherapy. ; Cancer Genetics and Genomics. ; Cancer Stem Cells.

Beschreibung / Inhaltsverzeichnis: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.

Kurzfassung: Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.

Materialart: Online-Ressource

Seiten: XI, 365 p. 22 illus., 21 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031445286

Serie: Interdisciplinary Cancer Research, 3

URL: https://doi.org/10.1007/978-3-031-44528-6

DOI: 10.1007/978-3-031-44528-6

DDC: 571.978

Sprache: Englisch

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Gastrointestinal Cancers: An Interdisciplinary Approach (2023)

Rezaei, Nima. [editor.]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Oncology. ; Immunotherapy. ; Tumors Immunological aspects. ; Nanomedicine. ; Cancer Biology. ; Cancer Therapy. ; Oncology. ; Immunotherapy. ; Tumour Immunology. ; Cancer Nanotechnology.

Beschreibung / Inhaltsverzeichnis: Interdisciplinary Approach in Gastrointestinal Cancers -- Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota-Immunity Axis -- Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach -- Metabolomics of Gastrointestinal Cancers -- Deregulation of Immune System in Gastric Cancer Development, How Immune Nutrition Might Restore the Functions of Immune Cells -- Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer -- Gastric Cancer and Helicobacter pylori -- Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers -- The Role of Tumor Microenvironment in Colon Cancer -- Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies -- The Interplay Between Immunity and Gut Microbiota in Colon Cancer -- Immunotherapy in Gastrointestinal Cancer Focusing on CAR-T Cell Therapy -- Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer -- Challenges of Onco-therapeutics in Early Onset Colorectal Cancer -- Unintentional Weight Loss and Malnutrition After Esophageal Cancer and Treatment -- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer Treatment. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. .

Kurzfassung: Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.

Materialart: Online-Ressource

Seiten: XI, 404 p. 22 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031483714

Serie: Interdisciplinary Cancer Research, 4

URL: https://doi.org/10.1007/978-3-031-48371-4

DOI: 10.1007/978-3-031-48371-4

DDC: 571.978

Sprache: Englisch

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Diseases at the Wildlife - Livestock Interface : Research and Perspectives in a Changing World (2021)

Vicente, Joaquín. [editor.] ; Vercauteren, Kurt C. [editor.] ; Gortázar, Christian. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Agriculture. ; Zoology. ; Veterinary medicine. ; Epidemiology. ; Ecology. ; Agriculture. ; Zoology. ; Veterinary Science. ; Epidemiology.

Beschreibung / Inhaltsverzeichnis: Part 1 Introduction -- 1 Host Community Interfaces: The Wildlife-Livestock -- 2 Natural And Historical Overview Of The Animal Wildlife-Livestock Interface -- 3 The Ecology Of Pathogens Transmission At The Wildlife-Livestock Interface: Beyond Disease Ecology, Towards Socio-Ecological System Health -- Part 2 Regional Perspectives Of Disease At The Wildlife-Livestock Interface -- 4 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Europe -- 5 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Asia -- 6 Characteristics And Perspectives Of Disease At Wildlife-Livestock Interface In Africa -- 7 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Oceania -- 8 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In North America -- 9 Characteristics And Perspectives Of Disease At The Wildlife-Livestock Interface In Central And South America -- Part 3 Characterization Of The Wildlife-Livestock Interface -- 10 Collecting Data To Assess The Interactions Between Livestock And Wildlife -- 11 Characterization Of Wildlife-Livestock Interfaces: The Need For Interdisciplinary Approaches And A Dedicated Thematic Field -- 12 Quantifying Transmission Between Wild And Domestic Populations -- Part 4 Synthesis And Conclusions -- 13 Synthesis And Future Perspectives Of The Study And Management Of Diseases At The Wildlife-Livestock Interface.

Kurzfassung: Shared diseases among wildlife, livestock and humans, often transboundary, are relevant to public health and global economy, as being highlighted currently relative to the global COVID19 pandemic. Diseases at these interfaces also impact the conservation of biodiversity and must be considered when managing wildlife. While wildlife and domestic livestock have coexisted in dynamic systems for thousands of years, spillover disease risks are higher today than in the past due to global patterns of increasing close contact and interactions among wildlife, livestock and humans in the context of complex, diverse and numerous circumstances. Multidisciplinary studies of animal interfaces, especially those involving wildlife, therefore, must be brought to the forefront so that knowledge gaps can be realized and filled to inform managers and policy makers. In the first part of the book authors illustrate and discuss ecological and epidemiological concepts related to the interfaces, with a vision towards socio-ecological system health. In addition, the history of past animal interfaces provides the necessary perspective to focus current questions, better understand present situations, and informs how we can best approach the future. The second part discusses the myriad of similar and differing wildlife- livestock interfaces found around the world from a regional point of view. The third part focuses on how to assess the spatial and temporal overlap between livestock and wildlife, and authors present new technical innovations about how inter-transmissions between wild and domestic populations can be quantified. An overview of main modeling approaches available to quantify multi-host disease transmission at the wildlife/livestock interface, illustrated with specific-case studies, is also presented. Finally, the need for interdisciplinary approaches and a dedicated thematic field to approach the wildlife/livestock interfaces and create opportunities to promote wildlife–livestock coexistence is emphasized. The concluding chapter presents perspectives and directions to better understanding disease dynamics at the wildlife/livestock interface, global change and implications for the future. The changing distribution of interfaces, ongoing human and environmental changes (e. g. climate warming, changes in animal production systems, etc.) and their likely impacts and consequences for the interfaces and disease transmission processes are all discussed.

Materialart: Online-Ressource

Seiten: XVI, 421 p. 77 illus., 64 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030653651

Serie: Wildlife Research Monographs, 3

URL: https://doi.org/10.1007/978-3-030-65365-1

DOI: 10.1007/978-3-030-65365-1

DDC: 577

Sprache: Englisch

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Life at High Pressure : In the Deep Sea and Other Environments (2021)

Macdonald, Alister.

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Life sciences. ; Physiology. ; Biodiversity. ; Biomechanics. ; Biophysics. ; Ecology. ; Life Sciences. ; Physiology. ; Biodiversity. ; Biomechanics. ; Biophysics.

Beschreibung / Inhaltsverzeichnis: High pressure and High pressure environments -- High pressure: molecules, chemical processes and cellular structures -- The high pressure micro-environment of vertebrate load bearing joints- Effects of high pressure on the activity of ordinary animals, including humans, and on the function of their excitable cells and ion channels -- The effects of decompression and subsequent re-compression on the activity of deep sea animals and eukaryote cells. The isobaric collection of deep sea animals.-Molecular adaptation to high pressure: proteins in deep sea animals -- Molecular adaptation to high pressure: membranes -- Prokaryotes at high pressure in the Oceans and the Deep Biosphere -- Hydrothermal vents: the inhabitants, their way of life and their adaptation to high pressure -- Buoyancy at depth -- Divers: Air breathing animals, including humans, at high pressure -- Adaptation to high pressure in the laboratory -- High pressure equipment used in the laboratory, at sea and at depth.

Kurzfassung: The book discusses the ways in which high hydrostatic pressure (i.e. water pressure) affects all grades of life which thrive at pressures much greater those in our normal environment. The deep sea is the best known high pressure environment, where pressures reach a thousand times greater than those at the surface, yet it is populated by a variety of animals and microorganisms. The earth’s crust supports microorganisms which live in water filled pores at high pressure. In addition, the load bearing joints of animals like ourselves experience pulses of hydrostatic pressure of a magnitude similar to the pressure at mid ocean depths. These pressures affect molecular structures and biochemical reactions. Basic cellular processes are drastically affected – the growth and division of cells, the way nerves conduct impulses and the chemical reactions which provide energy. Adaptation to high pressure also occurs in complex physiological systems such as those which provide buoyancy. Probably the greatest challenge to our understanding of adaptation to high pressure is the stabilisation of the nervous system of deep sea animals to avoid convulsions which pressure causes in shallow water animals. Additionally the book provides insight into the engineering required to study life at high pressure: equipment which can trap small deep sea animals and retrieve them at their high pressure, equivalent equipment for microorganisms, laboratory microscopes which can focus on living cells under high pressure, incubators for bacteria which require high pressure to grow, high pressure aquaria for marine animals and lastly and briefly, manned and unmanned submersible vessels, Landers and deep drill hole sampling. Rather like the organisms studied many laboratory instruments have been adapted to function at high pressure.

Materialart: Online-Ressource

Seiten: XVII, 445 p. 62 illus., 19 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030675875

URL: https://doi.org/10.1007/978-3-030-67587-5

DOI: 10.1007/978-3-030-67587-5

DDC: 577

Sprache: Englisch

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Social-Ecological Systems (SES) : From Risks and Insecurity to Viability and Resilience (2021)

Behnassi, Mohamed. [editor.] ; Gupta, Himangana. [editor.] ; El Haiba, Mahjoub. [editor.] ; [weitere]

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Schlagwort(e): Ecology . ; Bioclimatology. ; Environmental sciences Social aspects. ; Risk management. ; Social policy. ; Environment. ; Ecology. ; Climate Change Ecology. ; Environmental Social Sciences. ; IT Risk Management. ; Social Policy. ; Environmental Sciences.

Beschreibung / Inhaltsverzeichnis: Preface and Introduction -- Part I Risks and Impacts Enhancing the Vulnerability of Social-Ecological Systems -- Part II Environmental and Climate Change Impacts on Social-Ecological Systems – Conflict, Inequality and Human Security -- Part III Human Mobility and Social-Ecological Systems -- Part IV Enhancing the Sustainability and Resilience of Social-Ecological Systems – Some Recommended Paths -- Conclusions.

Kurzfassung: This book contributes to the multidisciplinary debate about social–ecological systems (SES) within the perspective of rethinking the nature of interaction between these systems, especially in the Anthropocene Era. Most chapters either deliberate on risk dynamics threatening current SES or stimulate thought processes to manage such risks and related negative implications. After analyzing the main drivers of SES vulnerability, the book highlights the shifts to be made to enhance the sustainability and resilience of these systems, mainly the integration and restructuring of governance frameworks, the reorganization of production and consumption systems far from conventional models based on consumerism, the elaboration of mitigation, adaptation, and SDGs implementation measures from a co-benefit perspective, and the consideration of appropriate approaches and paradigms while elaborating and implementing response mechanisms. This volume is relevant to researchers/experts, students, practitioners, and decision-makers from different scales and spheres.

Materialart: Online-Ressource

Seiten: XXXII, 265 p. 43 illus., 39 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030762476

URL: https://doi.org/10.1007/978-3-030-76247-6

DOI: 10.1007/978-3-030-76247-6

DDC: 577

Sprache: Englisch

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Movement Ecology of Afrotropical Forest Mammals (2023)

Reyna-Hurtado, Rafael. [editor.] ; Chapman, Colin A. [editor.] ; Melletti, Mario. [editor.]

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Schlagwort(e): Ecology . ; Vertebrates. ; Animal behavior. ; Population biology. ; Ecology. ; Vertebrate Zoology. ; Behavioral Ecology. ; Population Dynamics.

Beschreibung / Inhaltsverzeichnis: 1. What do we know about mammal movement in African tropical forests? -- 2. Movements patterns and population dynamics of giant forest hog groups in Kibale National Park, Uganda -- 3. Forest elephant movements in Central Africa – megafauna need megaspaces -- 4. Elephant movements, abundance and use of water sources in Kibale National Park, Uganda -- 5. Movement ecology and evolutionary history of forest buffalo -- 6. Site fidelity and home range shifts in a leaf-eating primate -- 7. Primate movements across the nutritional landscapes of Africa -- 8. Conditions facilitating a “landscape of fear from disease” in African forest mammals -- 9. Do seasonally frugivory and cognition shape foraging movements in wild western gorillas? -- 10. Females Move in Tight Crowds, Males Roam: Society and Movement Ecology of Mandrills -- 11. Linking Movement Ecology to Conservation Biology.

Kurzfassung: This book brings a unique perspective to animal movement studies because all studies come from African tropical environments where the great diversity, either biological and structurally (trees, shrubs, vines, epiphytes), present the animals with several options to fulfil their basic needs. These conditions have forced the evolution of unique movement patterns and ecological strategies. The book follows on our previous book “Movement Ecology of Neotropical Forest Mammals” but focuses on tropical African forests. Movement is an essential process in the life of all organisms. Animals move because they are looking for primary needs such as food, water, cover, mating and to avoid predators. Understanding the causes and consequences of animal movement is not an easy task for behavioural ecologists. Many animals are shy, move in secretive ways and are very sensible to human presence, therefore, studying the movements of mammals in tropical environments presents logistical and methodological challenges. However, researchers have recently started to be solved these challenges and exciting new information is emerging. In this book we are compiling a set of extraordinary studies where researchers have used new technology and the strongest methodological approaches to understand movement patterns in wild African forest mammals. This second book should inspire early career researchers to investigate wild mammal´s movements in some of the most amazing forest in the world: African tropical forests. .

Materialart: Online-Ressource

Seiten: XVII, 196 p. 42 illus., 36 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031270307

URL: https://doi.org/10.1007/978-3-031-27030-7

DOI: 10.1007/978-3-031-27030-7

DDC: 577

Sprache: Englisch

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Ethology and Behavioral Ecology of Sea Otters and Polar Bears (2021)

Davis, Randall W. [editor.] ; Pagano, Anthony M. [editor.]

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Schlagwort(e): Ecology . ; Conservation biology. ; Zoology. ; Biodiversity. ; Ecology. ; Conservation Biology. ; Zoology. ; Biodiversity.

Beschreibung / Inhaltsverzeichnis: Introduction -- Part I. Ethology and Behavioral Ecology of Sea Otters -- Taxonomy and Evolution of Sea Otters -- Sea Otter Behavior: Morphologic, Physiologic, and Sensory Adaptations -- Sea Otter Foraging Behavior -- Social Structure of Marine Otters: Inter and Intraspecific Variation -- Reproductive Behavior of Male Sea Otters -- Reproductive Behavior of Female Sea Otters and Their Pups -- Sea Otter Behavior and Its Influence on Littoral Community Structure -- Sea Otter Predator Avoidance Behavior -- Sea Otters and the Maritime Fur Trade -- Part II. Ethology and Behavioral Ecology of Polar Bears -- Polar Bear Taxonomy and Evolution -- Polar Bear Behavior: Morphologic and Physiologic Adaptations -- Polar Bear Foraging Behavior -- Polar Bear Reproductive and Denning Behavior -- Polar Bear Maternal Care, Neonatal Development, and Social Behavior -- Polar Bear Behavior in Response to Climate Change -- Human-Polar Bear Interactions.

Kurzfassung: Sea otters and polar bears are carnivorous marine mammals that still resemble their terrestrial ancestors. Compared with Cetacea (whales and dolphins), Sirenia (dugongs and manatees), and Pinnipedia (seals, sea lions, and walrus), they are less adapted for an aquatic life and the most recently evolved among marine mammals. Sea otters are amphibious but seldom come ashore, and polar bears primarily occur on sea ice or along the shore. When at sea, both species spend most of their time swimming at the surface or making short, shallow dives when foraging or pursuing prey. Indeed, polar bears rarely pursue seals in water. Nevertheless, polar bears are powerful swimmers and will stalk seals from the water. As with many other large carnivores, they are solitary hunters. Although sea otters are gregarious and form aggregations at sea called rafts, they are primarily asocial. Except during mating, the principal interaction among sea otters occurs between a female and offspring during the six-month dependency period. In large carnivores (e.g., wolves and lions) that feed on ungulates, sociality and cooperation are favored because of the need to capture large prey and defend carcasses. Polar bears, which are the largest terrestrial carnivore, are solitary hunters of seals and are neither gregarious nor social. Males and females briefly associate during courtship and mating. During this time, males aggressively compete for females. At other times, males generally avoid each other except for aggregations of males that form while summering on land, and females with cubs avoid males, which are known for infanticide. As with sea otters, the interaction of polar bears outside of mating occurs between a female and her offspring during the 2-3 year dependency period. This interaction is critically important when altricial cubs are born in the winter den. This book provides new insight into the ethology and behavioral ecology of sea otters and polar bears. Each chapter reviews the discoveries of previous studies and integrates recent research using new techniques and technology. The authors also address historic and current anthropogenic challenges for their survival as climate change alters entire marine ecosystems.

Materialart: Online-Ressource

Seiten: XIV, 363 p. 110 illus., 89 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030667962

Serie: Ethology and Behavioral Ecology of Marine Mammals,

URL: https://doi.org/10.1007/978-3-030-66796-2

DOI: 10.1007/978-3-030-66796-2

DDC: 577

Sprache: Englisch

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Tumor Microenvironment : State of the Science (2020)

Birbrair, Alexander. [editor.]

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Schlagwort(e): Cancer. ; Biomechanics. ; Cancer Biology. ; Biomechanics.

Beschreibung / Inhaltsverzeichnis: Metabolism in the tumor microenvironment -- Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment -- Viral hepatitis, inflammation, and tumour microenvironment -- Effects of HIV on the tumor microenvironment -- GLI2-mediated inflammation in the tumor microenvironment -- Stellate Cells in the Tumor Microenvironment -- Endothelial Progenitors in the Tumor microenvironment -- Chimeric antigen receptors for the tumour microenvironment -- Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A dragon-Like Weapon in a Non-Fantasy Game of Thrones -- Multiple dynamics in tumor microenvironment under radiotherapy -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more. Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Materialart: Online-Ressource

Seiten: XIII, 208 p. 28 illus., 26 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030445188

Serie: Advances in Experimental Medicine and Biology, 1263

URL: https://doi.org/10.1007/978-3-030-44518-8

DOI: 10.1007/978-3-030-44518-8

DDC: 571.978

Sprache: Englisch

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Tumor Microenvironment : Recent Advances (2020)

Birbrair, Alexander. [editor.]

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Schlagwort(e): Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.

Beschreibung / Inhaltsverzeichnis: Novel techniques to study the bone-tumor microenvironment -- An emerging model for cancer development from a tumor -- microenvironment perspective in mice and humans -- Effects of Exercise on the Tumour Microenvironment -- Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment -- Multimodal molecular imaging of the tumour microenvironment -- Necrosis in the tumor microenvironment and its role in cancer recurrence -- The Multifaceted Effects of Autophagy on the Tumor Microenvironment -- The Sociobiology of Brain Tumors -- Tumor microenvironment conditioning by abortive lytic replication of oncogenic γ-herpesviruses -- The microbiome as a component of the tumor microenvironment -- Index.

Kurzfassung: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Materialart: Online-Ressource

Seiten: XI, 160 p. 31 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030357276

Serie: Advances in Experimental Medicine and Biology, 1225

URL: https://doi.org/10.1007/978-3-030-35727-6

DOI: 10.1007/978-3-030-35727-6

DDC: 571.978

Sprache: Englisch

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Tumor Microenvironment : Non-Hematopoietic Cells (2020)

Birbrair, Alexander. [editor.]

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Schlagwort(e): Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.

Beschreibung / Inhaltsverzeichnis: Adipocytes in the tumour microenvironment -- Fibroblasts in the tumor microenvironment -- Mesenchymal stem cells in the tumor microenvironment -- Hepatic stellate cells in liver tumor -- Pancreatic stellate cells: The key orchestrator of the pancreatic tumor microenvironment -- Endothelial cells in the tumor microenvironment -- Lymphatic endothelial cell progenitors in the tumor microenvironment -- Oligodendrocyte progenitors in the tumor microenvironment -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.

Materialart: Online-Ressource

Seiten: X, 129 p. 31 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030371845

Serie: Advances in Experimental Medicine and Biology, 1234

URL: https://doi.org/10.1007/978-3-030-37184-5

DOI: 10.1007/978-3-030-37184-5

DDC: 571.978

Sprache: Englisch

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'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine (2020)

Masood, Nosheen. [editor.] ; Shakil Malik, Saima. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Oncology. ; Medical genetics. ; Bioinformatics. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Oncology. ; Medical Genetics. ; Bioinformatics. ; Microsystems and MEMS.

Beschreibung / Inhaltsverzeichnis: Module 1_ Introduction -- Module 2_ Cancer Metastasis -- Module 3_ Role of Transcriptomics in cancer treatment strategies -- Module 4_Computational approaches -- Module 5_Biostatistics and clinical oncology -- Module 6_Pharmacogenomics in cancer -- Chapter 7_Case studies.

Kurzfassung: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Materialart: Online-Ressource

Seiten: XVIII, 499 p. 59 illus., 50 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811510670

URL: https://doi.org/10.1007/978-981-15-1067-0

DOI: 10.1007/978-981-15-1067-0

DDC: 571.978

Sprache: Englisch

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Diseases of the Breast during Pregnancy and Lactation (2020)

Alipour, Sadaf. [editor.] ; Omranipour, Ramesh. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Human physiology. ; Medicine Research. ; Biology Research. ; Gynecology . ; Cancer Biology. ; Human Physiology. ; Biomedical Research. ; Gynecology.

Beschreibung / Inhaltsverzeichnis: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.

Kurzfassung: Symptoms of the breast in gravid women commonly represent physiological changes, however they may also be related to serious underlying breast disease; this challenging dilemma is aggravated by diagnostic and therapeutic limitations imposed by safety issues regarding the mother and fetus. A comprehensive coverage of all aspects of normal and pathologic breast changes during pregnancy and lactation, their diagnosis and management is provided in the present work. The organized structure of this book begins with gestational changes of the breast, while discussing safety, hazards, and arguments regarding diagnostic approaches. It then goes on by describing various clinical presentations and common and uncommon benign disorders during gravidity. The book then addresses pre-malignant lesions of the breast, opening the dialogue on how to manage these confusing lesions in pregnant and nursing women. It continues toward pregnancy-associated breast cancer, focusing on every facet of the problem, including epidemiology, diagnosis, treatment and complications, anesthetic considerations, prenatal care, and rare malignancies; and comes to an end by arguing main psychological concerns. In the midst of this orderly sequence fertility issues, pregnancy, and breastfeeding in women who have overcome their breast cancer are also discussed. This unique reference has been written by academic experts from different centers and diverse disciplines in a practical format. It is intended to be an ideal resource for every practitioner and specialist who manages complaints of gravid and nursing women or treats breast disorders in women of child bearing age.

Materialart: Online-Ressource

Seiten: XXV, 216 p. 55 illus., 38 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030415969

Serie: Advances in Experimental Medicine and Biology, 1252

URL: https://doi.org/10.1007/978-3-030-41596-9

DOI: 10.1007/978-3-030-41596-9

DDC: 571.978

Sprache: Englisch

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Systems Biology of MicroRNAs in Cancer (2022)

Schmitz, Ulf. [editor.] ; Wolkenhauer, Olaf. [editor.] ; Vera-González, Julio. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Tumor markers. ; Non-coding RNA. ; Cancers. ; Tumour Biomarkers. ; Non-coding RNAs.

Beschreibung / Inhaltsverzeichnis: Chapter 1. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- Chapter 2. Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- Chapter 3. Regulation of Immune Cells by MicroRNAs and MicroRNA-Based Cancer Immunotherapy -- Chapter 4. Machine-Learning-Based Methods and Best Practices of MicroRNA-Target Prediction and Validation -- Chapter 5. Turning Data to Knowledge: Online Tools, Databases and Resources in MicroRNA Research -- Chapter 6. Bioinformatics Methods for Modeling MicroRNA Regulatory Networks in Cancer -- Chapter 7. Analysis of the p53/MicroRNA Network in Cancer -- Chapter 8. Machine Learning Using Gene-Sets to Infer miRNA Function -- Chapter 9. miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect on Disease -- Chapter 10. ClustMMRA v2: A Scalable Computational Pipeline for the Identification of MicroRNA Clusters Acting Cooperatively on Tumor Molecular Subgroups -- Chapter 11. 3D Modeling of Non-coding RNA Interactions.

Kurzfassung: This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.

Materialart: Online-Ressource

Seiten: VII, 317 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783031083563

Serie: Advances in Experimental Medicine and Biology, 1385

URL: https://doi.org/10.1007/978-3-031-08356-3

DOI: 10.1007/978-3-031-08356-3

DDC: 571.978

Sprache: Englisch

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Tumor Microenvironment : Extracellular Matrix Components – Part B (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Stem cells. ; Regenerative medicine. ; Cytology. ; Cancer Microenvironment. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Cell Biology.

Beschreibung / Inhaltsverzeichnis: Elastin in the Tumor Microenvironment -- Decorin in the tumor microenvironment -- Syndecan-1 in the tumor microenvironment -- Versican in the tumor microenvironment -- Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment -- Lipoproteins and the Tumor Microenvironment -- The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility -- Thrombospondin in Tumor Microenvironment -- Tenascin-C function in glioma: immunomodulation and beyond -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development. Furthermore, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include elastin, decorin, syndecan-1, versican, lipoproteins, brevican, thrombospondin, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part B updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapters authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

Materialart: Online-Ressource

Seiten: XIII, 178 p. 36 illus., 33 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030484576

Serie: Advances in Experimental Medicine and Biology, 1272

URL: https://doi.org/10.1007/978-3-030-48457-6

DOI: 10.1007/978-3-030-48457-6

DDC: 571.978

Sprache: Englisch

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Immunotherapy (2020)

Naing, Aung. [editor.] ; Hajjar, Joud. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Immunology. ; Oncology. ; Cancer Biology. ; Immunology. ; Oncology.

Beschreibung / Inhaltsverzeichnis: Overview of Basic Immunology and Clinical Application -- Advances in Diagnostic Procedures and their Applications in the era of Cancer Immunotherapy -- Immunotherapy for Melanoma -- Immunotherapy in Lung Cancer: From a minor God to the Olympus -- Immunotherapy in Gastrointestinal Malignancies -- Current Landscape of Immunotherapy in Genitourinary Malignancies -- Immuno-oncology for Gynecologic Malignancies -- Immunotherapy for Neuro-Oncology -- Immunotherapy and Radiation -- CAR T-cells -- Skin Reactions to Immune Checkpoint Inhibitors -- Gastrointestinal Tract Adverse Events -- Immune-Related Adverse Events: Pneumonitis -- Hepatobiliary Adverse Events -- Immune Checkpoint Inhibitors (ICIs) Related Cardiotoxicity -- Renal Toxicity -- Immune-Related Oral, Otologic and Ocular Adverse Events -- Cancer Imaging in Immunotherapy -- The Microbiome in Immuno-Oncology -- New developments in the use of Patient-reported outcomes in Cancer Patients undergoing Immunotherapies.

Kurzfassung: Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.

Materialart: Online-Ressource

Seiten: XII, 339 p. 44 illus., 35 illus. in color. , online resource.

Ausgabe: 3rd ed. 2020.

ISBN: 9783030410087

Serie: Advances in Experimental Medicine and Biology, 1244

URL: https://doi.org/10.1007/978-3-030-41008-7

DOI: 10.1007/978-3-030-41008-7

DDC: 571.978

Sprache: Englisch

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Circulating Tumor Cells in Breast Cancer Metastatic Disease (2020)

Piñeiro, Roberto. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Stem cells. ; Cancer Biology. ; Biomedical Research. ; Biotechnology. ; Stem Cell Biology.

Beschreibung / Inhaltsverzeichnis: Preface -- Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. .

Kurzfassung: This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.

Materialart: Online-Ressource

Seiten: XV, 167 p. 15 illus., 14 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030358051

Serie: Advances in Experimental Medicine and Biology, 1220

URL: https://doi.org/10.1007/978-3-030-35805-1

DOI: 10.1007/978-3-030-35805-1

DDC: 571.978

Sprache: Englisch

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Artificial Intelligence and Precision Oncology : Bridging Cancer Research and Clinical Decision Support (2023)

Dlamini, Zodwa. [editor.]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Cancer. ; Oncology. ; Medical screening. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Oncology. ; Cancer Screening. ; Cancer Therapy. ; Tumour Biomarkers.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction: The Application of AI in Precision Oncology: Tailoring Diagnosis, Treatment, and the Monitoring of Disease Progression to the Patient -- Part I. Artificial Intelligence for Screening, Diagnosis, Monitoring in Precision Oncology -- Chapter 2. Application of AI in Novel Biomarkers Detection that Induce Drug Resistance, Enhance Treatment Regimens and Advancing Precision Oncology -- Chapter 3. Use of Artificial Intelligence in Implementing Mainstream Precision Medicine to Improve Traditional Symptom-driven Practice of Medicine: Allowing Early Interventions and Tailoring better-personalized Cancer Treatments -- Chapter 4. AI as a Novel Approach for Exploring ccfNAs in Personalized Clinical Diagnosis and Prognosis: Providing Insight into the Decision-Making in Precision Oncology -- Chapter 5. AI-Enhanced Digital Pathology and Radiogenomics in Precision Oncology -- Part II. Artificial Intelligence and Omics in Precision Oncology -- Chapter 6. Epigenetics Analysis Using Artificial Intelligence in the Era of Precision Oncology -- Chapter 7. Association of Metabolomics with AI in Precision Oncology: Emerging Perspectives for More Effective Cancer Care -- Chapter 8. Artificial Intelligence Application to Microbiomics Data for Improved Clinical Decision Making in Precision Oncology -- Part III. Artificial Intelligence in Cancer Therapy and the Clinical Applications -- Chapter 9. AI and Nanotechnology in Realizing the Goal of Precision Medicine: Tailoring the Best Treatment for Personalized Cancer Treatment -- Chapter 10. Artificial Intelligence-Based Medical Devices Revolution in Cancer Screening: Impact into Clinical Practice -- Chapter 11. Intelligent Drug Design and Use for Cancer Treatment: The Roles of AI and Precision Oncology in Targeting Patient-Specific Splicing Profiles -- Chapter 12. Applying Artificial Intelligence Prediction Tools for Advancing Precision Oncology in Immunotherapy: Future Perspectives in Personalized Care -- Chapter 13. Employing AI-Powered Decision Support Systems in Recommending the Most Effective Therapeutic Approaches for Individual Cancer Patients: Maximizing Therapeutic Efficacy -- Chapter 14. AI-Pathway Companion in Clinical Decision Support: Enabling Personalized and Standardized Care Along Care Pathways in Oncology -- Chapter 15. AI Tools Offering Cancer Clinical Applications for Risk Predictor, Early Detection, Diagnosis, and Accurate Prognosis: Perspectives in Personalised Care -- Chapter 16. Conclusion and Insights into the Future of AI in Precision Oncology.

Kurzfassung: This book highlights the use of artificial intelligence (AI), big data and precision oncology for medical decision making in cancer screening, diagnosis, prognosis and treatment. Precision oncology has long been thought of as ideal for the management and treatment of cancer. This strategy promises to revolutionize the treatment, control, and prevention of cancer by tailoring tests, treatments and predictions to specific individuals or population groups. In order to accomplish these goals, vast amounts of patient or population group specific data needs to be integrated and analysed to be able to identify key patterns or features which can be used to define or characterize the disease or the response to the disease in these individuals. These patterns or features can be as varied as molecular patterns or features in medical images. This level of data analysis and integration can only be achieved through the use of AI. The book is divided into three parts starting with a section on the use of artificial intelligence for screening, diagnosis and monitoring in precision oncology. The second part: Artificial intelligence and Omics in precision oncology, highlights the use of AI and epigenetics, metabolomics, microbiomics in precision oncology. The third part covers artificial intelligence in cancer therapy and its clinical applications. It also highlights the use of AI tools for risk prediction, early detection, diagnosis and accurate prognosis. This book, written by experts in the field from academia and industry, will appeal to cancer researchers, clinical oncologists, pathologists, medical students, academic teaching staff and medical residents interested in cancer research as well as those specialising as clinical oncologists.

Materialart: Online-Ressource

Seiten: XIV, 315 p. 64 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031215063

URL: https://doi.org/10.1007/978-3-031-21506-3

DOI: 10.1007/978-3-031-21506-3

DDC: 571.978

Sprache: Englisch

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Mercury and the Everglades. A Synthesis and Model for Complex Ecosystem Restoration : Volume III – Temporal Trends of Mercury in the Everglades, Synthesis and Management Implications (2020)

Pollman, Curtis D. [editor.] ; Axelrad, Donald M. [editor.] ; Rumbold, Darren G. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Biotic communities. ; Pollution. ; Water. ; Hydrology. ; Ecology. ; Ecosystems. ; Pollution. ; Water.

Kurzfassung: This book is the final installation in a three-volume series synthesizing 30 years of mercury research in the Florida Everglades. The first part of this book evaluates the occurrence of trends in both biota mercury concentrations and atmospheric mercury deposition. Through both empirical and deterministic analyses, the likely drivers of biota trends are identified. These analyses help lay the predicate for devising an overall strategy to mitigate and manage the Everglades mercury problem. The book concludes with a model analysis of the likely benefits and uncertainty attendant with implementing the leading candidate strategy for best reducing the Everglades mercury problem.

Materialart: Online-Ressource

Seiten: XV, 164 p. 78 illus., 72 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030556358

URL: https://doi.org/10.1007/978-3-030-55635-8

DOI: 10.1007/978-3-030-55635-8

DDC: 577

Sprache: Englisch

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Insect conservation and Australia’s Inland Waters (2020)

New, Tim R.

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Zoology. ; Conservation biology. ; Ecology. ; Zoology. ; Conservation Biology.

Beschreibung / Inhaltsverzeichnis: 1. Introduction: aquatic insects in Australia’s environments -- 1.1. The background to concern -- References -- 2. Major habitats -- 2.1. Introduction -- 2.2. Ponds and lakes -- 2.3. Streams and rivers -- References -- 3. Australian inland waters -- 3.1. Introduction -- 3.2. Waterfalls -- 3.3. Subterranean aquifers -- 3.4. Rock pools -- 3.5. Mound springs -- 3.6. Lakes -- 3.7. Billabongs -- 3.8. Streams and rivers -- 3.9. Exposed riverine sediments -- References -- 4. Monitoring freshwater macroinvertebrates -- 4.1. Scope and needs for assessments -- References -- 5. Threats: the background variations in condition -- 5.1. Introduction -- 5.2. Drought -- 5.3. Flood -- References -- 6. Major imposed threats -- 6.1. Introduction -- 6.2. Water temperature -- 6.3. Sedimentation -- 6.3.1. Mining -- 6.4. Pollution -- 6.5. Salinisation -- 6.6. Exploitation -- 6.7. Electrofishing -- 6.8. Changes to riparian vegetation -- 6.8.1. Emergent vegetation -- 6.9. Alien species -- 6.9.1. Plants -- 6.9.2. Fish -- 6.9.3. Mammals -- 6.10. River regulation -- 6.11. Fire -- 6.12. Urbanisation -- 6.13. Recreation -- 6.14. Ecological traps -- 6.15. Climate change -- References -- 7. Macroinvertebrates of inland waters -- 7.1. Introduction -- 7.2. The variety of aquatic insects -- 7.3. Other macroinvertebrates -- 7.3.1. Crustaceans -- 7.3.2. Molluscs -- References -- 8. Insects of Australia’s inland waters -- 8.1. Introduction -- 8.2. Ephemeroptera -- 8.3. Odonata -- 8.4. Plecoptera -- 8.5. Hemiptera -- 8.6. Coleoptera -- 8.7. Mecoptera -- 8.8. Megaloptera -- 8.9. Neuroptera -- 8.10. Lepidoptera -- 8.11. Trichoptera -- 8.12. Diptera -- 8.12.1. Control of aquatic pest flies -- References -- 9. Australia’s flagship freshwater insects -- 9.1. Introduction -- 9.2. Selected flagship taxa -- References -- 10. Ecology and management -- 10.1. Introduction -- 10.2. Dispersal -- 10.2.1. Impacts of urban lighting -- 10.2.2. Pond colonization -- References -- 11. Conservation -- 11.1. Introduction -- 11.2. Protected areas -- 11.3. Management and restoration -- 11.4. Fish conservation -- 11.5. Education and involvement -- 11.6. Artificial water bodies -- 11.7. Temporary ponds -- 11.8. Intermittent streams -- 11.9. Stormwater retention ponds -- 11.10. Refuges -- 11.11. Woody debris -- 11.12. Riparian zones -- 11.13. Perspective and prospects -- References -- Appendix 1 -- Index.

Kurzfassung: The inland waters of Australia, and their largely endemic insect inhabitants, are subject to a wide and increasing variety of threats that continue to change those environments and lead to losses of insect habitats and localised taxa. Many of those changes result from human needs for water and measures to assure supply in naturally varied flood/drought regimes on which anthropogenic changes are imposed, and to which aquatic biota are increasingly susceptible. This book is a broad overview of Australian aquatic insects, the problems they face as changes to key habitats occur, and measures by which their survival may be enhanced through practical conservation. As well as summarising the current conservation interest in aquatic insects in Australia, the text draws on information and case histories from many parts of the world to augment the generally more limited information from Australian taxa and their needs, to facilitate use and perspective on conservation practice by non-specialist conservation managers, whilst also being of value to entomologists interested more directly in aquatic insect ecology and conservation .The numerous references to many taxa, regions and ecological contexts provide examples for possible emulation in Australia, and summarises many practical lessons relevant to honing effective conservation across the range from individual threatened species to the more complex protection or restoration of aquatic communities in which insects play significant functional roles.

Materialart: Online-Ressource

Seiten: XIV, 303 p. 45 illus. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030570088

URL: https://doi.org/10.1007/978-3-030-57008-8

DOI: 10.1007/978-3-030-57008-8

DDC: 577

Sprache: Englisch

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Anoikis : How the Extracellular Matrix Regulates Life-or-Death Decisions (2021)

Frisch, Steven M. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cell death. ; Cancer Biology. ; Cell Death.

Beschreibung / Inhaltsverzeichnis: Preface -- Introduction -- The intersection of anoikis resistance and fatty acid metabolism in cancer -- Anoikis resistance in melanoma -- Anoikis mediated by stress-activated MAPK signaling pathways -- Metabolic Regulation of Anoikis -- Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells -- Role of the nuclear receptors in anoikis -- The roles of anoikis in cervical cancer -- Shc and the control of small GTPase dynamics in cellular anchorage -- Anoikis and the Human Gut Epithelium in Health and Disease -- Epithelial cell extrusion: the prelude to anoikis -- Microtubule modifications and mitochondria: role in anoikis.

Kurzfassung: This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of “anoikis”—the apoptosis that occurs when cells lack appropriate contact with the extracellular matrix—over 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field. This book provides both mechanistic and translational information regarding anoikis, in a convenient format. Mechanistically, the following topics will be addressed in detail: The role of MAP kinase signaling The role of Shc proteins as cellular anchorage sensors The role of cellular metabolism, and fatty acid metabolism in particular, and how they are affected by oncogenic transformation How epithelial cell extrusion – the prelude to anoikis—is regulated in normal and cancer cells The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: Colon cancer Melanoma Cervical cancer The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms. .

Materialart: Online-Ressource

Seiten: VIII, 202 p. 6 illus. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030738563

URL: https://doi.org/10.1007/978-3-030-73856-3

DOI: 10.1007/978-3-030-73856-3

DDC: 571.978

Sprache: Englisch

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Sika Deer: Life History Plasticity and Management (2022)

Kaji, Koichi. [editor.] ; Uno, Hiroyuki. [editor.] ; Iijima, Hayato. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Animal culture. ; Environmental management. ; Population biology. ; Evolution (Biology). ; Conservation biology. ; Ecology. ; Animal Science. ; Environmental Management. ; Population Dynamics. ; Evolutionary Biology. ; Conservation Biology.

Beschreibung / Inhaltsverzeichnis: 1.Introduction -- 2. The Process of Population Expansion of Sika Deer -- 3. The Impact of Sika Deer on Vegetation in Japan -- 4.Estimation of Sika Deer Abundance by Harvest-based Model and the Characteristics of their Population Dynamics -- 5. Variation in the local sika deer density between three areas of Japan with diverse climatic conditions -- 6. Ecological and evolutionary response of sika deer morphology to varying habitat environments: from body size to tooth wear -- 7. Reproductive variation of sika deer -- 8. Movement Patterns of Sika Deer in Hokkaido Region -- 9. Movement Patterns of Sika Deer in Tohoku Region -- 10. Movement patterns of sika deer in the mountainous regions of central Honshu -- 11. Movement Characteristics and Habitat Use of Sika Deer in Kanto Region, Central Japan -- 11. Movement patterns and activity range characteristics of sika deer in the Tanzawa Mountains, central Japan -- 13. Movement patterns of sika deer around Mt. Fuji, central Japan -- 14. Movement Patterns of Sika deer in Western Japan -- 15. Behavior of sika deer in clear-cut areas, plantations, and their surroundings -- 16. Effects of high densities of sika deer on vegetation and the restoration goal: Lessons from deer-vegetation interactions on Nakanoshima Island, Lake Toya -- 17. Irruptive Dynamics of Sika Deer: Search for the Mechanism -- 18. Food habits and body condition of the sika deer population in the Tanzawa Mountains, central Japans -- 19. Effects of sika deer and the unique relationship with forest vegetation in Yakushima Island -- 20. Conserving The Plant Community and Its Resilience Using Deer-Proof Fences in Japan -- 21. Vertebrate Scavenging on Sika Deer Carcasses and Its Effects on Ecological Processes -- 22. Impacts of Sika Deer Overabundance on The Structure and Functions of Dung Beetle Communities in Forest Ecosystems -- 23. Impact of Sika Deer on Soil Properties and Erosion -- 24. Responses of Ground-layer Vegetation and Soil Properties to Increased Population Density of Sika Deer and Environmental Conditions -- 25. Successional Pathways of a Warm-Temperate Forest After Disturbance: Effects of Clearcutting and Herbivory -- 26. Effect of Different Periods of Chronic Deer Herbivory on both Tall Forbs and Soil Seed Banks Following Deer Exclusions in a Damp Beech Forest -- 27. Indirect effects of deer overgrazing on stream ecosystems -- 28. Activity Patterns and Habitat Use Between Sika Deer and Japanese Serow -- 29. Sika in the British Isles: Population Ecology -- 30. History and Management of Sika Deer on the Delmarva Peninsula -- 31. The future of sika deer management in New Zealand; Invasive deer or hunting resource? -- 32. Adaptive Management of Sika Deer Populations on Hokkaido Island, Japan -- 34.Adaptive Management of Sika Deer in Hyogo Prefecture -- 35.Subpopulation Structure Based on Landscape Genetics as a Management Unit -- 36. Future Challenges for Research and Management of Sika Deer.

Kurzfassung: This book provides complete and up-to-date information on sika deer biology and its management, focusing on their life history with an integrated approach of population dynamics, morphology, genetics, and evolution. The expanding distribution of sika and its increase in population in Japan and other countries are causing damage to agriculture and forestry, impacting ecosystems and affecting other species. We are facing conflicting deer issues regarding the conservation of resource values and pest control of sika deer. This contributed volume compiles new findings focusing on the ecological plasticity of the sika deer. It aims to clarify the ecological characteristics of the deer by integrating studies of different approaches and provides a perspective for their management. The book consists of six parts. Part I introduces the ecological and management background behind the history of sika deer. The following four parts discuss movement ecology (Part II), impact on vegetation and bottom-up effect on sika deer (Part III), impact on ecosystem and its resilience (Part IV), and comparison of life-history characteristics between sika deer and other ungulate species (Part V). The last part (Part VI) covers the science-based management of sika deer. Contributed by recognized experts and young researchers of sika deer, this book appeals to researchers and professionals in wildlife biology and wildlife management, evolution, population dynamics, morphology, genetics, and reproductive physiology. .

Materialart: Online-Ressource

Seiten: XII, 641 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9789811695544

Serie: Ecological Research Monographs,

URL: https://doi.org/10.1007/978-981-16-9554-4

DOI: 10.1007/978-981-16-9554-4

DDC: 577

Sprache: Englisch

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Novel therapeutic approaches for gastrointestinal malignancies (2020)

Nagaraju, Ganji Purnachandra. [editor.] ; Peela, Sujatha. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Nanotechnology. ; Radiology. ; Molecular genetics. ; Cancer Biology. ; Nanotechnology. ; Radiology. ; Molecular Genetics.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Role of selected transcription factors in pancreatic and colorectal cancer growth and metastasis -- Chapter 2. Adiponectin in gastrointestinal malignancies -- Chapter 3. Small molecule-targeted therapies for GI cancers: success and failures -- Chapter 4. Epigenetic biomarkers for the detection of Gastrointestinal Cancers -- Chapter 5. CD151: A Lateral organizer and modulator of Tumor microenvironment in gastrointestinal cancers -- Chapter 6. Targeting Pathways in GI Malignancies -- Chapter 7. Identification of Potential Key Genes Involved In Progression of Gastric Cancer Using Bioinformatics Analysis -- Chapter 8. Recent Development in the biomarkers for the gastric cancer -- Chapter 9. Gastric Cancer and it’s remedy -- Chapter 10. An intergenic variant rs4779584 between SCG5 and GREM1 contributes to the increased risk of colorectal cancer: A meta-analysis -- Chapter 11. Phytochemicals plus nanomaterial’s on colorectal cancer -- Chapter 12. Pancreatic Ductal Adenocarcinoma and Type 2 Diabetes Mellitus: Distant Relatives or the Close Ones? -- Chapter 13. Tumor Biomarkers and Diagnosis of Pancreatic Adenocarcinoma -- Chapter 14. Immunotherapy in Gastrointestinal Malignancies -- Chapter 15. The Role of HIF-1α in Hepatocellular Carcinoma.

Kurzfassung: This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

Materialart: Online-Ressource

Seiten: XII, 259 p. 53 illus., 39 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811554711

Serie: Diagnostics and Therapeutic Advances in GI Malignancies,

URL: https://doi.org/10.1007/978-981-15-5471-1

DOI: 10.1007/978-981-15-5471-1

DDC: 571.978

Sprache: Englisch

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Molecular Biology of Human Cancers (2023)

Schulz, Wolfgang A.

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.

Beschreibung / Inhaltsverzeichnis: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.

Kurzfassung: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.

Materialart: Online-Ressource

Seiten: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.

Ausgabe: 2nd ed. 2023.

ISBN: 9783031162862

URL: https://doi.org/10.1007/978-3-031-16286-2

DOI: 10.1007/978-3-031-16286-2

DDC: 571.978

Sprache: Englisch

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Marine Coastal Ecosystems Modelling and Conservation : Latin American Experiences (2021)

Ortiz, Marco. [editor.] ; Jordán, Ferenc. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Freshwater ecology. ; Marine ecology. ; Environmental sciences Social aspects. ; Animal culture. ; Conservation biology. ; Ecology . ; Ecosystems. ; Freshwater and Marine Ecology. ; Environmental Social Sciences. ; Animal Science. ; Conservation Biology.

Beschreibung / Inhaltsverzeichnis: SECTION I. Natural and human environment of coastal ecosystems -- Chapter 1. Ecological modelling and conservation on the coasts of Mexico -- Chapter 2. SE Pacific: the ecosystem and its use along the Chilean and Peruvian coast -- SECTION II. Marine ecosystem models in the South East Pacific coast -- Chapter 3. Modelling the Northern Humboldt Current Ecosystem; from winds to predators -- Chapter 4. Marine ecosystem models in the South Pacific coast -- Chapter 5. Keystone Species Complexes and macroscopic properties for improving ecosystem-based conservation practices in kelp forest along the north-central Chilean coast -- Chapter 6. Exploring alternative management policies for benthic ecological systems of northern Chile (SE Pacific) -- SECTION III. Central Pacific, Caribbean and Atlantic coastal ecosystem models -- Chapter 7. How much biomass must remain at the sea after fishing to conserve ecosystem -- functioning? The case of the Monterey sardine in the Gulf of California, Mexico -- Chapter 8. Dynamic and spatial model of the coral reef of Banco Chinchorro Biosphere Reserve (Caribbean Sea) for assessment harvest scenarios: short-term responses -- Chapter 9. Ecological role of sharks assessed by Ecopath models -- SECTION IV. System-based conservation and management: conclusions -- Chapter 10. Graph theory in food webs: uses and applications for conservation of marine ecosystems -- Chapter 11. Modelling aim the conservation of coastal marine ecosystem in Latin America.

Kurzfassung: The book presents a collection of large-scale network-modeling studies on coastal systems in Latin America. It includes a novel description of the functioning of coastal complex ecosystems and also predicts how natural and human-made disturbances percolate through the networks. Coastal areas belong to the most populated ecosystems around the globe, and are massively influenced by human impacts such as shipping, mining, fisheries, tourism, pollution and human settlements. Even though many of these activities have facilitated socio-economic development, they have also caused a significant deterioration in natural populations, communities and ecosystems worldwide. Covering coastal marine ecosystems of Latin America such as the NE and SE Pacific, NW Atlantic and Caribbean areas, it discusses the construction of quantitative (Ecopath-Ecosim-Ecospace and Centrality of Node Sets) and semi-quantitative (Loop Analysis) multispecies trophic-network models to describe and assess the impacts of natural and human interventions like pelagic and benthic fishing as well as natural events such as El Niño, and La Niña. The book also features steady state (and/or near moving equilibrium) and dynamical models to support the management of exploited organisms, and applies and quantifies macroscopic indices, based on Ascendency (Ulanowicz) and Local Stability (Levins´ Loop Analysis). Further, it discusses the determination of the Keystone Species Complex Index, which is a holistic extension of the classical concept of Keystone Species (Paine), offering novel strategies for conservation monitoring and management.

Materialart: Online-Ressource

Seiten: X, 207 p. 41 illus., 3 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030582111

URL: https://doi.org/10.1007/978-3-030-58211-1

DOI: 10.1007/978-3-030-58211-1

DDC: 577

Sprache: Englisch

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Therapeutic potential of Cell Cycle Kinases in Breast Cancer (2023)

Mir, Manzoor. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancers. ; Cancer Therapy. ; Cancer Genetics and Genomics.

Beschreibung / Inhaltsverzeichnis: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.

Kurzfassung: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.

Materialart: Online-Ressource

Seiten: XVII, 373 p. 133 illus., 92 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811989117

URL: https://doi.org/10.1007/978-981-19-8911-7

DOI: 10.1007/978-981-19-8911-7

DDC: 571.978

Sprache: Englisch

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Ecology of Angola : Terrestrial Biomes and Ecoregions (2023)

Huntley, Brian John.

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Biodiversity. ; Conservation biology. ; Environmental management. ; Environmental geography. ; Ecology. ; Terrestial Ecology. ; Biodiversity. ; Conservation Biology. ; Environmental Management. ; Integrated Geography.

Beschreibung / Inhaltsverzeichnis: Introduction -- Biomes: Concepts, Characteristics and Terminology -- Profiles of Angola’s Biomes and Ecoregiens -- Landscapes: Geology, Hydrology and Geomorphology.

Kurzfassung: This open access book richly illustrates the first, and comprehensive, account of the country’s biomes and ecoregions, the driving forces that account for their diversity and vulnerability, and the ecological principles that provide an understanding of the patterns and processes that have shaped landscapes, ecoregions, and ecosystems. Angola encompasses the greatest diversity of terrestrial biomes and is the second richest in terms of ecoregions, of any African country. Yet its biodiversity and the structure and functioning of its ecosystems are largely undocumented. The author draws on personal field observations from over 50 years of involvement in ecological and conservation studies in Angola and across Southern Africa. The vast recent literature published by researchers in neighboring, better resourced countries provides depth to the accounts of ecological principles and processes relevant to Angola and thus contributing to the understanding and sustainable management of its natural resources. .

Materialart: Online-Ressource

Seiten: XIX, 459 p. 220 illus., 170 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031189234

URL: https://doi.org/10.1007/978-3-031-18923-4

DOI: 10.1007/978-3-031-18923-4

DDC: 577

Sprache: Englisch

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Inflammation, Infection, and Microbiome in Cancers : Evidence, Mechanisms, and Implications (2021)

Sun, Jun. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cancer Biology. ; Medical Microbiology. ; Biomedical Research. ; Human Physiology. ; Immunology.

Beschreibung / Inhaltsverzeichnis: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.

Kurzfassung: This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.

Materialart: Online-Ressource

Seiten: XII, 509 p. 31 illus., 28 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030679514

Serie: Physiology in Health and Disease,

URL: https://doi.org/10.1007/978-3-030-67951-4

DOI: 10.1007/978-3-030-67951-4

DDC: 571.978

Sprache: Englisch

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The Extracellular Matrix and the Tumor Microenvironment (2022)

Kovalszky, Ilona. [editor.] ; Franchi, Marco. [editor.] ; Alaniz, Laura D. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.

Kurzfassung: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Materialart: Online-Ressource

Seiten: X, 494 p. 40 illus., 34 illus. in color. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9783030997083

Serie: Biology of Extracellular Matrix, 11

URL: https://doi.org/10.1007/978-3-030-99708-3

DOI: 10.1007/978-3-030-99708-3

DDC: 571.978

Sprache: Englisch

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Ecosystem Services in Patagonia : A Multi-Criteria Approach for an Integrated Assessment (2021)

Peri, Pablo L. [editor.] ; Martínez Pastur, Guillermo. [editor.] ; Nahuelhual, Laura. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Applied ecology. ; Conservation biology. ; Ecology . ; Biodiversity. ; Freshwater ecology. ; Marine ecology. ; Ecosystems. ; Applied Ecology. ; Conservation Biology. ; Biodiversity. ; Freshwater and Marine Ecology.

Beschreibung / Inhaltsverzeichnis: Chapter 1 - Ecosystem services as a tool for decision-making in Patagonia -- Chapter 2- Assessment of provisioning ecosystem services in terrestrial ecosystems of Santa Cruz province, Argentina -- Chapter 3 - Grazing management and provision of ecosystem services in Patagonian arid rangelands -- Chapter 4 - Synergies and trade-offs among ecosystem services and biodiversity in different forest types inside and off-reserve in Tierra del Fuego, Argentina -- Chapter 5 - Shrubland management in northwestern Patagonia: an evaluation of its short-term effects on multiple ecosystem services -- Chapter 6 - Silvopastoral systems in northern Argentine-Chilean Andean Patagonia: Ecosystem services provision in a complex territory -- Chapter 7 - Ecosystem services values of the northwestern Patagonian natural grasslands -- Chapter 8 - The ecosystem services provided by peatlands in Patagonia -- Chapter 9 - Restoration for provision of ecosystem services in Patagonia-Aysén, Chile -- Chapter 10 - The North American beaver invasion and the impact over the ecosystem services in the Tierra del Fuego archipelago -- Chapter 11 - Social links for a nexus approach from an ecosystem services perspective in Central-East Patagonia -- Chapter 12 - Salmon farming: is it possible to relate its impact to the waste remediation ecosystem service? -- Chapter 13 - Using the ecosystem services approach to understand the distributional effects of marine protected areas in the Chilean Patagonia -- Chapter 14 - Socio-cultural valuation of ecosystem services in Southern Patagonia, Argentina -- Chapter 15 - Looking beyond ecosystem services supply: co-production and access barriers in marine ecosystems of the Chilean Patagonia -- Chapter 16 - Ecosystem services and human well-being: a comparison of two Patagonian social-ecological systems -- Chapter 17 - Urban Planning In Arid Northern Patagonia Cities To Maximize Local Ecosystem Services Provision -- Chapter 18 - Land size, native forests and ecosystem services inequalities in the rural Chilean Patagonia -- Chapter 19 - Imaginaries, transformations and resistances in Patagonian territories from a socio-ecological perspective -- Chapter 20 - The challenges of implementing ecosystem services in the Argentinean and Chilean Patagonia -- Chapter 21 - Natural capital and local employment in Argentine Patagonia -- Chapter 22 - Ecosystem services in Patagonia: a synthesis and future directions. .

Kurzfassung: This book aims to quantify and discuss how societies have directly and indirectly benefited from ecosystem services in Patagonia; not only in terms of provisioning and cultural services, but also regulating and supporting services. Patagonia, a region that stretches across two countries (ca. 10% in Chile and 90% in Argentina), is home to some of the most extensive wilderness areas on our planet. Natural grasslands comprise almost 30% of the Americas, including the Patagonian steppe, while Patagonian southern temperate forests are important for carbon sequestration and storage, play a pivotal role in water regulation, and have become widely recognized for their ecotourism value. However, profound changes are now underway that could affect key ecosystem functions and ultimately human well-being. In this context, one major challenge we face in Patagonia is that ecosystem services are often ignored in economic markets, government policies and land management practices. The book explores the synergies and trade-offs between conservation and economic development as natural landscapes and seascapes continue to degrade in Patagonia. Historically, economic markets have largely focused on the provisioning services (forest products, livestock) while neglecting the interdependent roles of regulating services (erosion and climate control), supporting services (nutrient cycling) and cultural services (recreation, local identity, tourism). Therefore, the present work focuses on ecosystem functions and ecosystem services, as well as on trends in biodiversity and the interactions between natural environments and land-use activities throughout Patagonia.

Materialart: Online-Ressource

Seiten: VII, 501 p. 85 illus., 58 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9783030691660

Serie: Natural and Social Sciences of Patagonia,

URL: https://doi.org/10.1007/978-3-030-69166-0

DOI: 10.1007/978-3-030-69166-0

DDC: 577

Sprache: Englisch

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Aquaculture Ecology (2023)

Dong, Shuang-Lin. [editor.] ; Tian, Xiang-Li. [editor.] ; Gao, Qin-Feng. [editor.] ; [weitere]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Vertebrates. ; Ecology. ; Vertebrate Zoology.

Beschreibung / Inhaltsverzeichnis: Introduction -- Aquaculture ecosystems -- Productivity and carrying capacity of aquaculture waters -- Interactions between aquaculture and environment -- Growth of aquaculture animals -- Effects of cyclical fluctuation of environmental factors on aquatic organisms -- Biological control of water quality in aquaculture -- Sediment and remediation of aquaculture ponds -- Integrated aquaculture and their structure optimization -- Land based intensive aquaculture -- Pond aquaculture in waterlogged salt-alkali land -- Fish cage farming in open waters -- Health maintenance and welfare of aquaculture animals -- Sustainability of aquaculture production systems.

Kurzfassung: This book introduces aquaculture ecology as a science of the interaction between commercial aquatic organisms as well as their farming activities and the environment, including the rationales of building and management of aquaculture systems. This book covers productivity and carrying capacity, effects of cyclical fluctuation of environmental factors on aquatic organisms, biological control of water quality, structural optimization of aquaculture systems and ecological prevention of disease. In the last chapter, aquaculture production systems are introduced from multiple perspectives. This book has been designed to provide a stimulating and informative text for researchers in aquaculture, fisheries as well as hydrobiology.

Materialart: Online-Ressource

Seiten: XVII, 573 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811954863

URL: https://doi.org/10.1007/978-981-19-5486-3

DOI: 10.1007/978-981-19-5486-3

DDC: 577

Sprache: Englisch

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Breast Cancer: From Bench to Personalized Medicine (2022)

Shakil Malik, Saima. [editor.] ; Masood, Nosheen. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Cancer Epidemiology. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Epidemiology. ; Cancer Genetics and Genomics.

Beschreibung / Inhaltsverzeichnis: Module 1_Overview of Breast Cancer -- Module 2_Cell and Molecular Biology of Breast Cancer-Diagnosis and Prognosis -- Module 3_Breast Cancer Treatment.

Kurzfassung: This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy. Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.

Materialart: Online-Ressource

Seiten: XVII, 536 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9789811901973

URL: https://doi.org/10.1007/978-981-19-0197-3

DOI: 10.1007/978-981-19-0197-3

DDC: 571.978

Sprache: Englisch

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Hormonal Pathology of the Uterus (2020)

Deligdisch-Schor, Liane. [editor.] ; Mareş Miceli, Angelica. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Endocrinology. ; Pathology. ; Cancer Biology. ; Endocrinology. ; Pathology.

Beschreibung / Inhaltsverzeichnis: 1. Biophysiology of the uterus: development, cyclic changes, menopause -- 2. Hormonal effects in reproductive technology (ovulation stimulation, in vitro fertilization) -- 3. Hormonal role and therapy in common benign uterine lesions: endometrial polyps, leiomyomas, adenomyosis -- 4. Endometrial hyperplasia; precancerous lesions of the endometrium. Hormone therapy -- 5. Endometrial Carcinoma. Endometriosis, Hormonal Role in Carcinogenesis. Hormonal Therapy -- 6. Menopausal Hormone Therapy. Contraceptives -- 7. Replacement hormone therapy for gender dysphoria and congenital sexual anomalies -- 8. Hormone therapy for endometrial neoplasia related to breast cancer therapy (Tamoxifen) -- 9. Endometrial histopatholigic changes in hormonal therapy (contraceptives, ovulation stimulation, hormone replacement therapy, hormonal antitumoral therapy).

Kurzfassung: Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of “natural” hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women’s health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women’s health. .

Materialart: Online-Ressource

Seiten: VIII, 185 p. 66 illus., 59 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030384746

Serie: Advances in Experimental Medicine and Biology, 1242

URL: https://doi.org/10.1007/978-3-030-38474-6

DOI: 10.1007/978-3-030-38474-6

DDC: 571.978

Sprache: Englisch

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Climate Change and Urban Environment Sustainability (2023)

Pathak, Bhawana. [editor.] ; Dubey, Rama Shanker. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Urban ecology (Biology). ; Biotic communities. ; Ecology. ; Urban Ecology. ; Ecosystems.

Beschreibung / Inhaltsverzeichnis: Chapter 1Climate Change and Urban Environment Sustainability: Issues and Challenges -- Chapter 2 Infrastructure, Energy Needs and Waste Management for Sustainable Urban Regions -- Chapter 3 Climate Change and Sustainable Urban Transport Environment -- Chapter 4 Importance of Climatological Inputs in the Green Infrastructure Design, Sustainable City Planning towards Better Urban Settlement -- Chapter 5 Methodology for Sustainable Urban Planning -- Chapter 6 Exploring Sustainable Food Systems for Urban Sustainability -- Chapter 7 Seagrasses in the Indian ocean region with special reference to urbanization -- Chapter 8 Water Quality Index: An Important Tool to Access Water Quality for Sustainable Development -- Chapter 9 Urbanization trends, Climate change and Environmental sustainability -- Chapter 10 Novel Technologies and Eco-friendly Lifestyle for Sustainable Cities -- Chapter 11 Spatial Analysis of Precipitation Climatology over India: Using satellite Remote Sensor -- Chapter 12 Timberline and Climate in the Indian Western Himalayan Region: Changes and Impact on Timberline Elevations -- Chapter 13 Design of Humanitarian Logistics Network Using Imperialist Competitive Algorithm -- Chapter 14 Impact of Climate Change Related Heat Stress on Thermophysiological Vulnerability Among Workers in Unorganized Sectors -- Chapter 15 Seagrass of Southeast Asia: Challenges, Prospects, and Management Strategies -- Chapter 16 Effect of Climate Change and Urbanization on Mangrove Ecosystems -- Chapter 17 Urbanization and climate change impact on habitat destruction and zoonotic species emergence -- Chapter 18 Roles of Community Resilience and Risk appraisal in climate change adaptation.

Kurzfassung: This book covers the understanding on relationship between climate change, urban development, and environment sustainability with emphasis on relevant issues and challenges of urban environment sustainability. It deals with the concept of climate resilient urban development, effective implementation of climate change adaptation and mitigation actions to promote urbanization from a social, economic, and environmental perspective. Climate change is a critical issue and having serious concern. Understanding the mechanism of climate change and climate variability is an important aspect and requires monitoring in their regional perspectives. Smart and resilient urbanization are essential in tackling the growing threat of climate instability. Different analytical and practical approaches to foster resilience and environmental sustainability in urban areas covering the recent trends, developments and tools related to urban environment, sustainability, and climate change. There is a big demand of understanding on the relationship between climate change, urban environment sustainability due to fast urbanization and an urgent need for constructive and effective mechanism to protect the life and property of human being from expected or anticipated hazards and disasters. This book is of interest and useful to academicians, researchers, scientists, environmentalists, land resource managers, climate change scientists, forest administrators. Also, the book serves as a reference to researchers and students of agriculture, forestry, ecology, soil science, and environmental sciences. Policy makers will also find this to be a useful read.

Materialart: Online-Ressource

Seiten: XIII, 329 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811976186

Serie: Disaster Resilience and Green Growth,

URL: https://doi.org/10.1007/978-981-19-7618-6

DOI: 10.1007/978-981-19-7618-6

DDC: 577

Sprache: Englisch

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Green Infrastructure and Climate Change Adaptation : Function, Implementation and Governance (2022)

Nakamura, Futoshi. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Biotic communities. ; Landscape ecology. ; Environmental economics. ; Forestry. ; Bioclimatology. ; Ecosystems. ; Landscape Ecology. ; Environmental Economics. ; Forestry. ; Climate Change Ecology.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Introduction -- Part 1: Concept and synthesis -- Chapter 2: Concept and application of hybrid infrastructure -- Chapter 3: An Economic Analysis of Optimal Hybrid Infrastructure: A Theoretical Approach in a Hydro-Economic Model -- Chapter 4: Flood Management Policy in Shiga Prefecture, Japan: Implementation Approach of a Risk-Based Flood Management System at Catchment Scale -- Chapter 5: Toward social infrastructure: typological idea for evaluating implementation potential of green infrastructure -- Part 2 : Forest ecosystem -- Chapter 6: Riparian Forests and Climate Change: Interactive Zone of Green and Blue Infrastructure -- Chapter 7: Improvement of the flood-reduction function of forests based on their interception evaporation and surface storage capacities -- Chapter 8: Forests for water: A step-by-step guide for payment schemes -- Part 3: River and floodplain ecosystem (including paddy field and other farmlands) -- Chapter 9: Wetland Paddy Fields as Green Infrastructure against Flood -- Chapter 10: Change in Floodwater Retention Function of a Paddy Field due to Cultivation Abandonment in a Depopulating Rural Region in Japan -- Chapter 11: Paddy field as a green inflastructure: their ecosystem services and threatening drivers -- Part 4: Wetland ecosystem (including flood-control pond) -- Chapter 12: Flood-control basins as green infrastructures: flood-risk reduction, biodiversity conservation and sustainable management in Japan -- Chapter 13: Natural Succession of Wetland Vegetation in a Flood-control Pond Constructed on Abandoned Farmland -- Chapter 14: Biodiversity Conservation through Various Citizen Activities in a Flood Control Basin -- Part 5: Urban and city ecosystem -- Chapter 15: Toward holistic Urban Green Infrastructure Implementation -- Chapter 16: Changes in the Use of Green Spaces by Citizens before and during the First COVID-19 Pandemic: A Big data analysis using mobile-tracking GPS data in Kanazawa, Japan -- Chapter 17: Land Use Planning as a Green Infrastructure in a Rural Japanese Depopulated Town -- Chapter 16: Towards an Equitable Distribution of Urban Green Spaces for People and Landscapes; An opportunity for Portland's Green Grid -- Part 6: Coast and estuary ecosystem -- Chapter 19: "Effectiveness and Sustainability of Coastal Hybrid Infrastructures for Low-Frequency Large-Scale Disasters -- A Case Study of Coastal Disaster Assessment for a Complex Disaster" -- Chapter 20: Challenging a Hybrid between Green and Gray Infrastructure – Coastal Sand-covered Embankments -- Chapter 21: Green Infrastructures in Megacity Jakarta: Current Status and Possibilities of Mangroves for Flood Damage Mitigation -- Chapter 22: Implementation of Japanese Blue Carbon Offset Crediting Projects -- Part 7: Economic evaluation -- Chapter 23: Understanding Preference Differences among Individuals for the Reduction in Flood Risk by Green Infrastructure -- Chapter 24: Assessing Public Preference for Construction of Giant Seawalls Using the Best–Worst Scaling Approach -- Chapter 25: "Coastal communities’ preferences of grey, green and hybrid infrastructure against unexpected catastrophes: A case study of Japan" -- Chapter 26: Carbon storage and substitution benefits of harvested wood products -- Part 8: Governance -- Chapter 27: Social System in Collaborative Activities for Conserving Coastal Pine Forest in Karatsu City, Kyusyu, Japan -- Chapter 28: Governance for realizing multifunctional floodplain; flood control, agriculture, and biodiversity in Yolo Bypass Wildlife Area, California, USA -- Chapter 29: Analysis of the description of the multifunctionality of farmland in the administrative plans of local municipalities.

Kurzfassung: This open access book introduces the function, implementation and governance of green infrastructure in Japan and other countries where lands are geologically fragile and climatologically susceptible to climate change. It proposes green infrastructure as an adaptation strategy for climate change and biodiversity conservation. In the face of climate change, dams, levees and floodways built as disaster prevention facilities do not sufficiently function against extraordinary events such as mega-floods and tsunami disasters. To prevent those disasters and loss of biodiversity in various ecosystems, we should shift from conventional hard measures to more adaptive strategies using various functions that natural and semi-natural ecosystems provide. Green infrastructure is an interconnected network of waterways, wetlands, woodlands, wildlife habitats and other natural areas that support native species, maintain natural ecological processes, sustain air and water resources and contribute to the health and quality of life for communities and people. Green infrastructure has mainly been discussed from adaptation strategy perspectives in cities and urban areas. However, to protect cities, which are generally situated at downstream lower elevations, we explore the preservation and restoration of forests at headwater basins and wetlands along rivers from a catchment perspective. In addition, the quantitative examination of flood risk, biodiversity, and social-economic benefits described in this book brings new perspectives to the discussion. The aim of this book is to accelerate the transformative changes from gray-based adaptation strategies to green- or hybrid-based strategies to adapt to climate change. The book provides essential information on the structure, function, and maintenance of green infrastructure for scientists, university students, government officers, and practitioners.

Materialart: Online-Ressource

Seiten: XII, 506 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2022.

ISBN: 9789811667916

Serie: Ecological Research Monographs,

URL: https://doi.org/10.1007/978-981-16-6791-6

DOI: 10.1007/978-981-16-6791-6

DDC: 577

Sprache: Englisch

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Biology and Ecology of Earthworms (2022)

Edwards, Clive A. ; Arancon, Norman Q.

New York, NY :Springer US :

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Schlagwort(e): Ecology . ; Environmental management. ; Refuse and refuse disposal. ; Zoology. ; Ecology. ; Ecology. ; Environmental Management. ; Waste Management/Waste Technology. ; Zoology.

Beschreibung / Inhaltsverzeichnis: Ch. 1. Earthworm Morphology -- Ch. 2. Earthworm Physiology -- Ch. 3. Earthworm Diversity, Dispersal, and Geographical Distribution -- Ch. 4. Earthworm Life Histories and Biology -- Ch. 5. Earthworm Ecology: Populations -- Ch. 6. Earthworm Ecology: Communities -- Ch. 7. The Influence of Environmental Factors on Earthworms -- Ch. 8. The Role of Earthworms in Organic Material and Nutrient Cycles -- Ch. 9 -- Interactions Between Earthworms, Microorganisms, and Other Invertebrates -- Ch. 10. Role of Earthworms in Soil Structure, Fertility and Productivity -- Ch.11. Adverse and Beneficial Aspects of Earthworms -- Ch. 12. Earthworms in Environmental Management -- Ch.13. Earthworms in Organic Waste Management -- Ch.14. Effects of Agricultural Practices and Chemicals on Earthworms. .

Kurzfassung: Biology and Ecology of Earthworms is established as a key valuable text for students of agriculture, soil science, and soil invertebrate zoology and ecology. This is the 4th Edition of the popular textbook which reviews all aspects of earthworm biology and ecology. The book has been fully revised and updated throughout. Particular changes include: new treatments of earthworm taxonomy, diversity, migration and geographical distribution; interactions between earthworms and other soil organisms, especially microorganisms and soil-borne pests and diseases; as well as the importance of earthworms in organic waste management.

Materialart: Online-Ressource

Seiten: XVI, 567 p. 92 illus., 11 illus. in color. , online resource.

Ausgabe: 4th ed. 2022.

ISBN: 9780387749433

URL: https://doi.org/10.1007/978-0-387-74943-3

DOI: 10.1007/978-0-387-74943-3

DDC: 577

Sprache: Englisch

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Sustainable Squirrel Conservation : A Modern Reassessment of Family Sciuridae (2023)

Steiner, Moriz. ; Huettmann, Falk.

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Animal culture. ; Sustainability. ; Geographic information systems. ; Environment. ; Ecology. ; Animal Science. ; Sustainability. ; Geographical Information System. ; Environmental Sciences.

Beschreibung / Inhaltsverzeichnis: Part 1: Introduction to squirrels of the world and their conservation trends. Chapter 1: The World’s Squirrel Taxonomy -- Chapter 2: Evolution, habitat trends, and extinction rate estimates of the world squirrels -- Part 2: Squirrels of the world in the Anthropocene. Chapter 3: Habitat Trends and the Squirrel-Human Interface -- Chapter 4: A Meta-analysis based on Open Access Big Data Mining of Global Predicted Squirrel Distribution Models with Machine Learning for IUCN Conservation Status and Trend Policy Assessments -- Chapter 5: Squirrels in Cities -- Chapter : Squirrels in the Tropics -- Chapter 7: Squirrels on Islands -- Chapter 8: Tree squirrels in old-growth forests? -- Chapter 9: Can squirrels be used as indicators to identify and protect old-growth forest reserves? -- Chapter 10: Squirrel Economics -- Part 3: Problems and governance in the squirrel world. Chapter 11: Squirrel Hunting Regulations and Enforcement (Or Lack Thereof) -- Chapter 12: Where do the World’s Squirrel Hotspots and Coldspots of 230+ species go with Climate change 2100? -- Chapter 13: Squirrel’s marginalization and modern lack of conservation and poor sustainability outlook as a call to good action -- Part 4: First conclusions and the way forward. Chapter 14: A Conservation Management SWOT analysis for over 300 Squirrels of the World using 132 GIS layers confirming the PESTLE assessment -- Chapter 15: First Conclusions, Success stories, and Calls-to-action for the conservation of the world’s squirrels.

Kurzfassung: This book attempts to move the family of squirrels (Sciuridae) out of the shadow of large charismatic mammals and to highlight management failures with the goal of moving towards an improved conservation approach. Particular attention is paid to the influence of taxonomic science on squirrel conservation. In addition, the authors show how human-driven climate change, global change and modern politics are shaping global squirrel populations as well as their surrounding environments and ecosystems. Squirrels are widespread around the globe, naturally occurring on every continent except Antarctica and Oceania, and they are certainly among the animals most commonly encountered in everyday life. Despite this, the authors of this volume identify worrying gaps in squirrel conservation. Squirrels are often hunted, trapped, poached, and stressed, and management strategies and legislation are often devised in the absence of proper knowledge of issues such as population sizes, taxonomies, and trends. Together, this can result in severe population declines and even species extinction. By assessing their taxonomic situation, ecology, the evolution and divergence of Sciuridae around the globe, and squirrels’ well-being across habitats, the authors set a baseline from which to launch future investigations into the conservation of squirrels and other species. Additionally, the authors highlight the influences of climate change, unsustainable growth, and various man-made threats to the future of this family.

Materialart: Online-Ressource

Seiten: XVII, 380 p. 228 illus., 221 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031235474

URL: https://doi.org/10.1007/978-3-031-23547-4

DOI: 10.1007/978-3-031-23547-4

DDC: 577

Sprache: Englisch

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Oncology: Genomics, Precision Medicine and Therapeutic Targets (2023)

Tuli, Hardeep Singh. [editor.] ; Yerer Aycan, Mükerrem Betül. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Cancer Genetic aspects. ; Oncology. ; Therapeutics. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Oncology. ; Therapeutics.

Beschreibung / Inhaltsverzeichnis: Chapter 1 Evolution of translational cancer therapeutics -- Chapter 2 Oncology: Way forward from clinical and molecular diagnosis to treatment -- Chapter 3 Oncogenic genomics alterations in cancer patient -- Chapter 4 Altered mRNA expression profiles in cancer patients -- Chapter 5 microRNAs and long non-coding RNAs as key targets -- Chapter 6 Oncogenic alterations translated into diagnostics -- Chapter 7 Precision medicine in oncology -- Chapter 8 Precision medicine – translation of individualistic treatment in oncology -- Chapter 9Pharmacogenetics and Pharmacogenomics in Precision Medicine -- Chapter 10 Pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines -- Chapter 11 Biomarkers in Precision Medicine in oncology -- Chapter 12 Bioinformatics and biostatistics in Precision Medicine -- Chapter 13 Omics in Precision medicine -- Chapter 14 Translational therapeutic targets : from bench to clinical trials -- Chapter 15 Strength of integartive genomic alterations, precision medicine and therapeutic targets as treatment choice in patient care.

Kurzfassung: This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.

Materialart: Online-Ressource

Seiten: XVI, 274 p. 23 illus., 15 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819915293

URL: https://doi.org/10.1007/978-981-99-1529-3

DOI: 10.1007/978-981-99-1529-3

DDC: 571.978

Sprache: Englisch

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Cancer Research: An Interdisciplinary Approach (2023)

Rezaei, Nima. [editor.]

Cham :Springer Nature Switzerland :

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Schlagwort(e): Cancer. ; Cancer Treatment. ; Stem cells. ; Cytology. ; Medical genetics. ; Immunology. ; Cancer Biology. ; Cancer Therapy. ; Cancer Stem Cells. ; Cell Biology. ; Medical Genetics. ; Immunology.

Beschreibung / Inhaltsverzeichnis: Interdisciplinary Approaches in Cancer Research -- Role of Immune Cells in the Tumor Microenvironment -- Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME) -- Role of Mesenchymal Stem/Stromal Cells in Cancer Development -- Cancer-associated Fibroblasts and Their Role in Cancer Progression -- The Role of Tumoroids in Cancer Research -- Myokines Expression in Cancer Cachexia -- Epigenetics in Cancer Biology -- Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation -- Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity -- Molecular Mechanisms of Metal-induced Carcinogenesis -- Epi-drugs Targeting RNA Dynamics in Cancer -- Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management -- Malignancies in Inborn Errors of Immunity -- Hematopoietic Stem Cell Transplantation in Patients with Inborn Errors of Immunity and Malignancy -- Personalized Immuno-oncology with Immunodeficiency Mouse Models -- Allergy and Cancer: New Perspectives -- Depression and Cancer: the Inflammatory Bridge -- Impact of Cancer-Related Sarcopenia on Systemic Immune Status -- Surveillance of Subclinical Cardiovascular Complications in Childhood Cancer Survivors: Exercise as a Diagnostic and Therapeutic Modality.

Kurzfassung: Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore interdisciplinary approaches might help to find solutions to many unanswered questions and challenges about cancer. The rapid flow of interdisciplinary research in cancer during recent years has increased our understanding of the nature of cancers. Such interdisciplinary approaches could be helpful for both the diagnosis and the development of more effective therapeutic strategies. The “Interdisciplinary Cancer Research” series publishes comprehensive volumes on different cancers and presents the most updated and peer-reviewed articles on human cancers. Over the past decade, increased cancer research has greatly improved our understanding of the nature of cancerous cells which has led to the development of more effective therapeutic strategies to treat cancers. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN).

Materialart: Online-Ressource

Seiten: XI, 611 p. 31 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031324581

Serie: Interdisciplinary Cancer Research, 1

URL: https://doi.org/10.1007/978-3-031-32458-1

DOI: 10.1007/978-3-031-32458-1

DDC: 571.978

Sprache: Englisch

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Rangeland Wildlife Ecology and Conservation (2023)

McNew, Lance B. [editor.] ; Dahlgren, David K. [editor.] ; Beck, Jeffrey L. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Conservation biology. ; Zoology. ; Animal culture. ; Biotic communities. ; Freshwater ecology. ; Marine ecology. ; Ecology. ; Conservation Biology. ; Zoology. ; Animal Science. ; Ecosystems. ; Freshwater and Marine Ecology.

Beschreibung / Inhaltsverzeichnis: 1. Introduction to Rangeland Wildlife Ecology and Conservation -- Part I Rangeland Ecosystems and Processes -- 2. Rangelands of Western North America -- 3. A History of North American Rangelands -- 4. Western Rangeland Livestock Production Systems and Grazing Management -- 5. Manipulation of Rangeland Wildlife Habitats -- 6. Role and Management of Fire in Rangelands -- 7. Water is Life: Importance and Management of Riparian Areas for Rangeland Wildlife -- 8. Rangeland Biodiversity -- Part II Species Accounts -- 9. Prairie Grouse -- 10. Sage-Grouse -- 11. Quails -- 12. Rangeland Songbirds -- 13. Wetland Birds of Rangelands -- 14. Avian Predators in Rangelands -- 15. Burrowing Rodents -- 16. Mesocarnivores of Western Rangelands -- 17. Black-tailed and Mule Deer -- 18. White-tailed Deer -- 19. Pronghorn -- 20. Elk -- 21. Feral Equids -- 22. Mountain Ungulates -- 23. American Bison -- 24. Large Carnivores -- 25. Amphibians and Reptiles -- 26. Insects in Grassland Ecosystems -- Part III Social-Ecological Considerations -- 27. Wildlife, Rural Communities, and the Rangeland Livelihoods they Share: Opportunities in a Diverse Economies Approach -- 28. Living with Predators: A 20-year Case Study in the Blackfoot River Watershed of Montana -- 29. A Perspective on Rangeland and Wildlife Disciplines: Similarities Over Differences -- 30. Future of Rangeland Wildlife in North America.

Kurzfassung: This open access book reviews the importance of ecological functioning within rangelands considering the complex inter-relationships of production agriculture, ecosystem services, biodiversity, and wildlife habitat. More than half of all lands worldwide, and up to 70% of the western USA, are classified as rangelands—uncultivated lands that often support grazing by domestic livestock. The rangelands of North America provide a vast array of goods and services, including significant economic benefit to local communities, while providing critical habitat for hundreds of species of fish and wildlife. This book provides compendium of recent data and synthesis from more than 100 experts in wildlife and rangeland ecology in Western North America. It provides a current and in-depth synthesis of knowledge related to wildlife ecology in rangeland ecosystems, and the tools used to manage them, to serve current and future wildlife biologists and rangeland managers in the working landscapes of the West. The book also identifies information gaps and serves as a jumping-off point for future research of wildlife in rangeland ecosystems. While the content focuses on wildlife ecology and management in rangelands of Western North America, the material has important implications for rangeland ecosystems worldwide.

Materialart: Online-Ressource

Seiten: XI, 1023 p. 111 illus., 94 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031340376

URL: https://doi.org/10.1007/978-3-031-34037-6

DOI: 10.1007/978-3-031-34037-6

DDC: 577

Sprache: Englisch

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How to Fulfil the UN Sustainability Goals : Rethinking the Role and Concept of Money in the Light of Sustainability (2023)

Fuders, Felix.

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Sustainability. ; Energy policy. ; Energy and state. ; Schools of economics. ; Ecology. ; Sustainability. ; Energy Policy, Economics and Management. ; Heterodox Economics.

Beschreibung / Inhaltsverzeichnis: Part I - Money and its role in the economy -- 1. Introduction: the world is on a collision course -- 2. What is money? -- 3. Money is like the ‘blood’ of the economy -- Part II Money and the unsustainability in stricto sensu -- 4. The growth imperative inherent in our financial system -- 5. The effect of the money interest rate on money supply, demand and growth -- 6. Economic growth in the long run is unsustainable -- 7. Economic growth or unemployment -- Part III. Money and inequality -- 8. Our current monetary system produces income inequality -- 9. Moral-ethic aspects of interest-induced inequality -- Part IV Natural money as solution -- 10. Gesell’s solution -- 11. Gesell’s Solution to achieve the SDGs -- 12. How to implement Gesell’s solution in today’s world -- 13. Alternatives to Gesell’s solution -- 14. Experiences with Gesell’s solution -- Part V Outlook and final considerations -- 15. Towards a Development at Human Scale -- 16. Economic resilience in presence of externals shocks -- 17. Final considerations.

Kurzfassung: This book combines the field of economics —especially monetary theory— with other disciplines like ecology, physics, humanities, social sciences and development theory. This transdisciplinary approach makes the book a unique contribution for researchers, students, policy makers and professionals working in governmental or nongovernmental institutions, as well as anyone interested in society’s well-being and achieving a true social-ecological transformation. It is written in an accessible language in order to reach a broad audience. In 2015, more than 190 world leaders recognized that the world is on a “collision course” (Max-Neef) and committed to 17 Sustainable Development Goals (SDGs). Many conferences and high-level meetings have been held since then, and one of the most frequently discussed topics is how to finance these goals. There is a widespread belief that coming up with more money for sustainable development will “do the trick”. Usually, the discussions focus on finding additional financial resources in order to achieve the goals faster. In this book it is argued that not only is more money needed, but it needs to be a different kind of money. The book demonstrates that ALL but one of the SDGs are directly linked to our monetary system, which —being completely unnatural— can be seen as the most important, but at the same time least recognized, reason for market failure. Many people think we just need to do more, faster, better. Very few say that we have done things fundamentally wrong and that the institutions and values which motivated us to do those things need to be changed. It will be concluded that only if we change our unnatural design of money to a more natural one, will we be able to reach these goals.

Materialart: Online-Ressource

Seiten: XXV, 357 p. 54 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031377686

URL: https://doi.org/10.1007/978-3-031-37768-6

DOI: 10.1007/978-3-031-37768-6

DDC: 577

Sprache: Englisch

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Ecosystem and Species Adaptations in the Andean-Amazonian Region : Traditional Land-Use Systems in Peru (2023)

Sabogal, Ana.

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Biotic communities. ; Botany. ; Bioclimatology. ; Ecophysiology. ; Ecology. ; Ecosystems. ; Plant Science. ; Climate Change Ecology. ; Ecophysiology.

Beschreibung / Inhaltsverzeichnis: 1- Basic concepts of ecology applied on the neotropic ecosystems -- 2 - Natural resources and sustainable development in Peru -- 3 - Classification of the Peruvian Ecosystems -- 4 - Peruvian ecosystems geography -- 5 - Biodiversity and endemism of the Andes -- 6 - Ecological communities, populations and metapopulations -- 7 - Succession and change of the ecosystems -- 8 - Biodiversity of the Amazonia Basin -- 9 - Peruvian protected natural areas -- 10 - The paramo ecosystems -- 11 - The Humboldt National Forest -- 12 - The Northwest Biosphere Reserve -- 13 - Urban ecosystems and development -- 14 - Climate changes -- 15 - Traditional land-use systems and agrobiodiversity in Peru -- Index.

Kurzfassung: This book focuses on ecosystems and species adaptations in the unique Peruvian Andean-Amazonian region. The presence of the Andes as the backbone is the cause of the huge ecosystem diversity and biodiversity of species that characterize the Andean-Amazonian ecosystems. The complex orography of Peru as results of the Andes presence in its tropical setting favors the occurrence of local climatic features that provide diverse environmental conditions for multiple, unique plant and animal species, many of them endemic to the Andes. The book will introduce the reader to the climatic history and geography of the Peruvian Andes and the Peruvian Natural Areas Protection system focusing on the Manu and Northwest biosphere reserves given their relevant ecological importance as well as the relationship between them and the local population. Important global topics like urbanization, deglaciation and global warming will be analyzed and discussed due to their impact in the Andes-Amazon ecosystems. Finally, the traditional land-use systems, agrobiodiversity and agrodiversity in Peru are present and linked with the climate change adaptations.

Materialart: Online-Ressource

Seiten: XXI, 200 p. 31 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031443855

URL: https://doi.org/10.1007/978-3-031-44385-5

DOI: 10.1007/978-3-031-44385-5

DDC: 577

Sprache: Englisch

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Current Advances in Osteosarcoma : Clinical Perspectives: Past, Present and Future (2020)

Kleinerman, Eugenie S. [editor.] ; Gorlick, Richard. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Medical microbiology. ; Cytology. ; Pediatrics. ; Cancer Biology. ; Medical Microbiology. ; Cell Biology. ; Pediatrics.

Beschreibung / Inhaltsverzeichnis: Adjuvant and Neoadjuvant Chemotherapy for Osteosarcoma: A Historical Perspective -- Part 1: Surgical Considerations and Outcomes -- Limb Salvage and Reconstruction Options in Osteosarcoma -- Advances in the functional assessment of patients with sarcoma -- Part II: Novel Therapeutic Approaches Based on Biology -- Radiopharmaceuticals for Treatment of Osteosarcoma -- HER-2 Targeted Therapy in Osteosarcoma -- Aerosolized Chemotherapy for Osteosarcoma -- The Histone Deacetylase inhibitor Entinostat/Syndax 275 in Osteosarcoma -- Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease -- Using liquid biopsy in the treatment of patient with osteosarcoma -- Part III: Novel Immunotherapeutic Approaches -- Genetically modified T-cell therapy for osteosarcoma: into the roaring 2020’s -- Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Natural Killer Cell Immunotherapy for Osteosarcoma -- Nanocapsule delivery of IL-12 -- Discovery of cell surface vimentin (CSV) as a sarcoma target and development of CSV-targeted IL-12 immune therapy -- Part IV: Survivorship and Late Effects -- Editorial Comments on late effects -- Anthracycline-Induced Cardiotoxicity: Causes, mechanisms & prevention -- Exercise and Physical Activity in Patients with Osteosarcoma and Survivors -- Index.

Kurzfassung: This thoroughly revised second edition complied in 2 books is an up-to-date overview of the current clinical advances in sarcoma and osteosarcoma. The new edition features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, these essential volumes also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists focused in sarcoma.

Materialart: Online-Ressource

Seiten: XIII, 212 p. 24 illus., 17 illus. in color. , online resource.

Ausgabe: 2nd ed. 2020.

ISBN: 9783030430320

Serie: Advances in Experimental Medicine and Biology, 1257

URL: https://doi.org/10.1007/978-3-030-43032-0

DOI: 10.1007/978-3-030-43032-0

DDC: 571.978

Sprache: Englisch

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Microplastic sources, fate and solution (2023)

Khan, Anish. [editor.] ; Wang, Chongqing. [editor.] ; Asiri, Abdullah M. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Ecology . ; Medicine Research. ; Biology Research. ; Biotechnology. ; Environmental engineering. ; Bioremediation. ; Environmental management. ; Ecology. ; Biomedical Research. ; Biotechnology. ; Environmental Engineering/Biotechnology. ; Environmental Management.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Microplastics in the freshwater and earthbound conditions: Prevalence, destinies, impacts and supportable arrangements -- Chapter 2. Effect of microplastics on microbial network -- Chapter 3.Quick estimation of microplastic in meat -- Chapter 4.Source, migration and toxicology of microplastics in soil -- Chapter 5.Impact of microplastics on nutrient -- Chapter 6.Agricultural plastic mulching as a source of microplastics in the terrestrial condition -- Chapter 7.Worldly and spatial varieties of microplastics in side of the road dust from provincial and urban area, : Implications for diffuse contamination -- Chapter 8.Microplastic particles in the Persian/Arabian Gulf -- Chapter 9.Impacts of microplastic biofilms on supplement cycling in recreated freshwater frameworks -- Chapter 10.Conveyance, bounty and dangers of microplastics in nature -- Chapter 11.Accumulation system of antibiotic medication hydrochloride from fluid arrangements by nylon microplastics -- Chapter 12.Expulsion of microplastics by means of drinking water treatment: Current information and future headings -- Chapter 13.Impacts of polystyrene microplastics on larval advancement, settlement, and transformation -- Chapter 14.Bioaccumulation of microplastics and its in vivo connections -- Chapter 15.Microplastics in oceanic situations: Toxicity to trigger biological results -- Chapter 16.Waterfront sea elements decrease the fare of microplastics to the vast sea -- Chapter 17.Barnacles as potential bioindicator of microplastic contamination in Hong Kong -- Chapter 18.Microplastic accumulation in remote ocean dregs from the Rockall Trough -- Chapter 19.Environmental microplastics: A survey on current status and points of view -- Chapter 20.The joined poisonous quality impact of microplastics and nonylphenol on microalgae Chlorella pyrenoidosa -- Chapter 21.Daylight interceded cadmium discharge from shaded microplastics containing cadmium color in watery stage -- Chapter 22.Environmental microplastic testimony in a urban environment and an assessment of transport -- Chapter 23.Biofilm modifies antibiotic medication and copper adsorption practices onto polyethylene microplastics.

Kurzfassung: This book provides an overview of the sources, occurrence, fate and solution of microplastics. Microplastics in sediment and soil environment have been only scarcely surveyed, and no profound discussion on microplastics removal is summarized until this book. Here we focus on sharing clear schematic information and the book sufficiently supports important microplastic topics: such as microbial network, microplastic toxicology and accumulation, agricultural plastics, nylon microplastics, polystyrene microplastics, polyethylene microplastics and many more. The book mainly provides an overview of recent advances in knowledge of sources, occurrence, distribution, chemical behavior and ecological threats while it also presents information related to feasible solutions for microplastic pollution management. This comprehensive resource will be valuable up-to-date knowledge for environmental scientists, ecotoxicologists, ecologists, marine biologists, environmental chemists in the academic field and this book is intended to be beneficial information for environmental managers, water suppliers, wastewater treatment, plastics manufacturer, and policy makers as well.

Materialart: Online-Ressource

Seiten: XI, 129 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789819906956

URL: https://doi.org/10.1007/978-981-99-0695-6

DOI: 10.1007/978-981-99-0695-6

DDC: 577

Sprache: Englisch

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Natural Products for Cancer Chemoprevention : Single Compounds and Combinations (2020)

Pezzuto, John M. [editor.] ; Vang, Ole. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Cancer Biology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Chemoprevention of Cancer - Past,Present, and Future -- Chapter 2. Resveratrol for Cancer Prevention: Current Gaps and Opportunities -- Chapter 3. Pterostilbene as a Potent Chemopreventive Agent in Cancer -- Chapter 4. Pharmacokinetics and Bioavailability Enhancement of Natural Products -- Chapter 5. Vitamin D Compounds and Cancer Stem Cells in Cancer Prevention -- Chapter 6. Anti-cancer Effects of Silibinin – The Current Status in Cancer Chemoprevention -- Chapter 7. Adjuvant Value of Turmeric Extract (Containing Curcumin) in Colorectal Cancer Management -- Chapter 8. Cancer Prevention by Tea Polyphenols -- Chapter 9. The Chemopreventive Power of Isothiocyanates -- Chapter 10. Xanthohumol and Structurally Related Prenylflavonoids for Cancer Chemoprevention and Control -- Chapter 11. Anthocyanins and Cancer Prevention -- Chapter 12. Grape ChemopreventiveAgents AgainstAngiogenesis and Metastasis -- Chapter 13. Punicagranatum L. Constituents for Cancer Prevention, Chemosensitisation and Therapeutic Treatment -- Chapter 14. Cancer ChemopreventivePotential of Epidermal Growth Factor Receptor Inhibitors from Natural Products -- Chapter 15. Anti-cancer Dynamics of Natural Phytochemical Inhibitors of Cyclin-dependent Kinases -- Chapter 16. Pro-apoptotic Properties of Chemopreventive Agents -- Chapter 17. The Use of Anti-inflammatory Agents for Cancer Chemoprevention -- Chapter 18. Combination Chemoprevention by Targeting the Epigenome -- Chapter 19. Perspective – a positive cocktail effect of the bioactive components in the diet.

Kurzfassung: This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research. .

Materialart: Online-Ressource

Seiten: XX, 629 p. 59 illus., 39 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030398552

URL: https://doi.org/10.1007/978-3-030-39855-2

DOI: 10.1007/978-3-030-39855-2

DDC: 571.978

Sprache: Englisch

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Regulation of Cancer Immune Checkpoints : Molecular and Cellular Mechanisms and Therapy (2020)

Xu, Jie. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Immunology. ; Biomedical Research.

Beschreibung / Inhaltsverzeichnis: Introduction -- Molecular and cellular functions of CTLA-4 pathway -- Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond -- Discovery of new immune checkpoints: family grows up -- Mechanisms of resistance to checkpoint blockade therapy -- Molecular events behind adverse effects -- Rational discovery of response biomarkers -- Spatiotemporal changes in checkpoint molecule expression -- Functions of checkpoint molecules beyond immune evasion -- Genetic alterations and checkpoint expression -- Regulations on messenger RNA: wires and nodes -- Folded or degraded in endoplasmic reticulum -- Mono- and poly-ubiquitination: tags for fates -- Lysosome as the black hole for checkpoint molecules -- Phosphorylation: a fast switch for checkpoint signalling -- Palmitoylation as a signal for delivery -- Checkpoints under traffic control: from and to organelles -- Exosome and secretion: action on? -- Macromolecules and antibody-based drugs -- Mechanisms inspired targeting peptides -- Small molecular inhibitors -- Therapeutic development of immune checkpoint blockers -- Concluding remarks.

Kurzfassung: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.

Materialart: Online-Ressource

Seiten: X, 653 p. 105 illus., 57 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811532665

Serie: Advances in Experimental Medicine and Biology, 1248

URL: https://doi.org/10.1007/978-981-15-3266-5

DOI: 10.1007/978-981-15-3266-5

DDC: 571.978

Sprache: Englisch

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A Catalogue of Ecosystem Services in Slovakia : Benefits to Society (2020)

Mederly, Peter. [editor.] ; Černecký, Ján. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Biogeography. ; Physical geography. ; Environmental policy. ; Landscape ecology. ; Biodiversity. ; Ecosystems. ; Biogeosciences. ; Physical Geography. ; Environmental Policy. ; Landscape Ecology. ; Biodiversity.

Beschreibung / Inhaltsverzeichnis: Part I: Ecosystem Services Basics -- Chapter 1. Overview of the ecosystem services concept -- Part II: Ecosystem Services of Slovakia -- Chapter 2. Methodology of national ES assessment -- Chapter 3. Provisioning ecosystems services -- Chapter 4. Regulatory ecosystem services and supporting ecosystem functions -- Chapter 5. Cultural ecosystems services -- Part III: Synthesis -- Chapter 6. Synthesis of ecosystem services assessment in Slovakia.

Kurzfassung: This book provides the first comprehensive assessment of ecosystem services (ES) for the territory of the Slovak Republic. Although the ES approach is widely used for the evaluation of the benefits of natural capital and biodiversity for people, this book has a unique character. It provides an assessment of 18 individual ES, which are divided into three main groups - provisioning, regulatory/supporting and cultural ES. For each of ES, a brief theoretical and methodological overview is given, followed by spatial assessment based on own original methodology and dataset of 40 map layers. Besides, an evaluation of main ES groups and overall ES assessment is realized. This book emphasizes the key role of nature protection areas, large areas of forest ecosystems and mountain and sub-mountain areas, for the preservation of the various functions of the healthy landscape and ecosystems. The complexity of the book guarantees its usefulness - not only as the knowledge base for the territory of Slovakia but also as the methodological tool for worldwide researchers.

Materialart: Online-Ressource

Seiten: XXVI, 244 p. 114 illus., 110 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030465087

URL: https://doi.org/10.1007/978-3-030-46508-7

DOI: 10.1007/978-3-030-46508-7

DDC: 577

Sprache: Englisch

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Histone Mutations and Cancer (2021)

Fang, Dong. [editor.] ; Han, Junhong. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Molecular genetics. ; Proteins . ; Cancer Biology. ; Molecular Genetics. ; Protein Biochemistry.

Beschreibung / Inhaltsverzeichnis: Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.

Kurzfassung: This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.

Materialart: Online-Ressource

Seiten: VII, 96 p. 17 illus., 15 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9789811581045

Serie: Advances in Experimental Medicine and Biology, 1283

URL: https://doi.org/10.1007/978-981-15-8104-5

DOI: 10.1007/978-981-15-8104-5

DDC: 571.978

Sprache: Englisch

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Autophagy in Stem Cell Maintenance and Differentiation (2023)

Shravage, Bhupendra V. [editor.] ; Turksen, Kursad. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Stem cells. ; Cytology. ; Developmental biology. ; Cancer Stem Cells. ; Cell Biology. ; Developmental Biology and Stem Cells.

Beschreibung / Inhaltsverzeichnis: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.

Kurzfassung: This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.

Materialart: Online-Ressource

Seiten: VIII, 288 p. 41 illus., 34 illus. in color. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9783031173622

Serie: Stem Cell Biology and Regenerative Medicine, 73

URL: https://doi.org/10.1007/978-3-031-17362-2

DOI: 10.1007/978-3-031-17362-2

DDC: 571.978

Sprache: Englisch

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Tropical Forest Ecosystem Services in Improving Livelihoods For Local Communities (2023)

Samdin, Zaiton. [editor.] ; Kamaruddin, Norfaryanti. [editor.] ; Razali, Sheriza Mohd. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Biotic communities. ; Forestry. ; Ecology . ; Ecosystems. ; Forestry. ; Ecology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Conservation of Tropical Forest for the Well-being of Community -- Chapter 2. Forest Pathology in Ecosystem Services -- Chapter 3. Non-Timber Forest Problems: NTFPs in Conservation and Development Initiatives -- Chapter 4. Characterizing and assessing forest density and productivity of Ulu Muda Forest Reserve based on satellite imageries -- Chapter 5. Temporal Reduction of Forest Ecosystem Services and Drivers of Deforestation -- Chapter 6. A Trade-Off Analysis of Sustainable Landscape Planning: A Case Study of Sintang Regency (Heart of Borneo), Kalimantan -- Chapter 7. Land Use and Land Cover Change Prediction using ANN-CA model -- Chapter 8. Linking Blue-Green Infrastructure to Micoclimate and Human Thermal Comfort for Urban Cooling: A review -- Chapter 9. Assessing the Community Participation in Ecotourism at Ulu Muda Forest Reserve Malaysia -- Chapter 10. Improving Livelihood of Sugar Palm Community in Malaysia -- Chapter 11. Local community involvement in Mangrove Forest conservation and edutourism in Kampung Sijangkang -- Chapter 12. The Resilience of the Natural Resource Dependency of Indigenous People in a Wilderness Area: The Case of Virachey National Park, Cambodia -- Chapter 13. Reconciling the values and needs of wildlife and local communities: A way forward to deal with human-wildlife conflicts in Malaysia.

Kurzfassung: This edited book covers major importance of tropical forest diversity and its values to vegetation, wildlife, and the local community. It addresses the current issues and opportunities in the Southeast Asia’s tropical forests. This book lays the groundwork for a better understanding of tropical forest ecosystem services. Ecosystem services has four concepts: provisioning, regulating, cultural and supporting services. In an era of rapid population growth and increasing pressure on tropical natural resources, ecosystem services have become central to the discussion of climate change mitigation. The values of tropical forest ecosystem services deserve to be the highlighted when it comes to shaping responsible behaviors towards sustainable development goals (SDGs). This book is of interest and useful to researchers and academics teaching in the field of tropical forest conservation, tropical ecosystems, tropical products technology, ecotourism, forest plantation management, bio industrial economy, agroforestry business and marketing. Professionals, foresters, industrial entrepreneurs, ecologists, and a valuable source of reference to the relevant researchers and students in the region.

Materialart: Online-Ressource

Seiten: VIII, 249 p. 1 illus. , online resource.

Ausgabe: 1st ed. 2023.

ISBN: 9789811933424

URL: https://doi.org/10.1007/978-981-19-3342-4

DOI: 10.1007/978-981-19-3342-4

DDC: 577

Sprache: Englisch

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Pharmacotherapeutic Botanicals for Cancer Chemoprevention (2020)

Kumar, Manish. [editor.] ; Sharma, Ashita. [editor.] ; Kumar, Praveen. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Medical genetics. ; Pharmaceutical chemistry. ; Bioinformatics. ; Cancer Biology. ; Medical Genetics. ; Pharmaceutics. ; Bioinformatics.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Phytochemicals in Cancer Chemoprevention: A Brief Perspective -- Chapter 2. Phytochemicals in Modulating Signalling Cascades in Cancer Cells -- Chapter 3. Diverse cancer therapeutic interactions: complexities in cancer management -- Chapter 4. Natural Products as Chemosensitizers for Adjunct Therapy in Cancer Management -- Chapter 5. Dietary phytochemicals as epigenetic modulators in cancer prevention: Emerging research trends, gaps, and future perspectives -- Chapter 6. Modulation of Cancer Cell Metabolism and Microenvironment by Phytochemicals -- Chapter 7. Role of Nutrigenetics and Nutrigenomics in Cancer Chemoprevention -- Chapter 8. Nano-delivery carriers for Enhanced Bioavailability of Antitumor Phytochemicals -- Chapter 9. Biphasic Effects of Phytochemicals and their Relevance to Cancer Therapeutics -- Chapter 10. Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention -- Chapter 11. 3 Dimensional Cell Culture Techniques in Cancer Research -- Chapter 12. Animal Models Systems of Cancer for Preclinical Trials -- Chapter 13. Cancer Chemoprevention by Natural Plant Products and Their Derivatives: Clinical Trials.

Kurzfassung: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Materialart: Online-Ressource

Seiten: XII, 337 p. 120 illus., 39 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811559990

URL: https://doi.org/10.1007/978-981-15-5999-0

DOI: 10.1007/978-981-15-5999-0

DDC: 571.978

Sprache: Englisch

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Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers (2020)

Veera Bramhachari, Pallaval. [editor.] ; Neelapu, Nageswara Rao Reddy. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Molecular genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology. ; Cancer Biology. ; Molecular Genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Potential Role of Biomarkers, Biosensors, Technologies and Computational Methods in Early Detection of Gastrointestinal Cancer -- Chapter 2. Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer -- Chapter 3. Development and Evaluation of Biomarkers for Early Detection of Cancer -- Chapter 4. Prognostic Molecular Markers for Gastrointestitinal cancer -- Chapter 5. Metabolic Markers for Early Detection of Gastrointestinal Cancer -- Chapter 6. Current Status of MicroRNA-based Biomarkers for Gastric Cancer -- Chapter 7. Genetic Susceptibility Markers of Gastrointestinal Cancer -- Chapter 8. Approaches For Early Detection Of Gastrointestinal Cancer -- Chapter 9. Biosensors and its Applications for Early Detection of Gastrointestitinal Cancer -- Chapter 10. Application of Nanotechnology in Early Detection of Gastrointestinal Cancer -- Chapter 11. Genetic Marker Identification for the Detection of Early-Onset Gastrointestitinal Cancer Through Genome Wide Association Studies -- Chapter 12. Big Data Analytics to Discover Diagnostics and Therapeutics for Gastrointestitinal Cancer -- Chapter 13. System Biology Approach for Early Prognosis of Gastrointestinal Cancer.

Kurzfassung: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Materialart: Online-Ressource

Seiten: XXIII, 231 p. 38 illus., 34 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9789811544316

Serie: Diagnostics and Therapeutic Advances in GI Malignancies,

URL: https://doi.org/10.1007/978-981-15-4431-6

DOI: 10.1007/978-981-15-4431-6

DDC: 571.978

Sprache: Englisch

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Evolution of Marine Coastal Ecosystems under the Pressure of Global Changes : Proceedings of Coast Bordeaux Symposium and of the 17th French-Japanese Oceanography Symposium (2020)

Ceccaldi, Hubert-Jean. [editor.] ; Hénocque, Yves. [editor.] ; Komatsu, Teruhisa. [editor.] ; [weitere]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Oceanography. ; Physical geography. ; Water. ; Hydrology. ; Environment. ; Ecosystems. ; Ocean Sciences. ; Earth System Sciences. ; Water. ; Environmental Sciences.

Beschreibung / Inhaltsverzeichnis: Part I: Introductory Communications -- Chapter 1. Our Future and The Oceans -- Chapter 2. General guidelines for future exchanges in marine science and technology between the two Sociétés franco-japonaises d’Océanographie -- Part II: Identification and Analysis of Environmental Stressors -- Chapter 3. The Japan Sea: a changing Pacific Asian marginal sea -- Chapter 4. Statistical analysis of surface circulation in Sagami Bay using High Frequency（HF）Radar -- Chapter 5. Statistical analysis of high frequency pCO2 data acquired with the Astan buoy (Southern Western English Channel, off Roscoff) -- Chapter 6. Spatial variation in pCO2 based on 16 years of in-situ measurements in the Seto Inland Sea, Japan -- Chapter 7. The Bay of Seine: a resilient socio-eco-system under cumulative pressures -- Chapter 8. Effect of bacterial infection on the expression of stress proteins and antioxidative enzymes in Japanese flounder -- Part III: Impacts on Socio-Eco-Systems and Biological Resources -- Chapter 9. A Review of the Effects of Global Warming and Currents Trends on Fisheries and its Impact on Important Commercial Species in Japan -- Chapter 10. Physiology of winter coral bleaching in temperate zone -- Chapter 11. Preliminary report of impacts of the 2011 earthquake and tsunami and subsequent events on macrobenthic community in a shallow brackish lagoon in Sendai Bay, Japan -- Chapter 12. Post-tsunami oyster feeding environment in Nagatsuraura Bay for three years -- Chapter 13. Seagrass-oyster farmers interaction detected by eelgrass DNA analysis in Hinase area of the Seto Inland Sea, Japan -- Chapter 14. Fisheries Biology of Blue Sharks in Sagami Bay, Japan -- Part IV: Vulnerability of Coastal Ecosystems and Risk Assessment -- Chapter 15. Temperature and salinity changes in coastal waters of Western Europe: variability, trends and extreme events -- Chapter 16. Risk Based Consenting of Offshore Renewable Energy Projects (RICORE) -- Chapter 17. Does global warming favour the occurrence of recent blue mussel mortality events in France? -- Chapter 18. Integrated ecosystem management for exploited coastal ecosystem dynamics under oligotrophication and climate changes -- Chapter 19. Forty years of decline and 10 years of management plan: are European eels (Anguilla anguilla) recovering? -- Chapter 20. The management of Mediterranean coastal habitats: a plea for a socio-ecosystem-based approach.

Kurzfassung: Coastal and estuarine environments at the interface of terrestrial and marine areas are among the most productive in the world. However, since the beginning of the industrial era, these ecosystems have been subjected to strong anthropogenic pressures intensified from the second half of the 20th century, when there was a marked acceleration in the warming (climate change) of the continents, particularly at high latitudes. Coastal ecosystems are highly vulnerable to alteration of their physical, chemical and biological characteristics (marine intrusion, acidification of marine environments, changes in ecosystems, evolution and artificialization of the coastline, etc.). In contact with heavily populated areas, these environments are often the receptacle of a lot of chemical and biological pollution sources that significantly diminish their resilience. In this context of accelerated evolution and degradation of these areas important for food security of many populations around the world, it is necessary to better identify the factors of pressure and understand, at different scales of observation, their effects and impacts on the biodiversity and on the socio-eco-systems, in order to determine the degree of vulnerability of these coastal ecosystems and the risks they face. A transdisciplinary and integrated approach is required to prevent risks. Within this framework, operational coastal oceanography occupies an important place but also the implementation of a true socio-eco-system approach in order to set up an environmentally friendly development.

Materialart: Online-Ressource

Seiten: XXIX, 517 p. 248 illus., 194 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030434847

URL: https://doi.org/10.1007/978-3-030-43484-7

DOI: 10.1007/978-3-030-43484-7

DDC: 577

Sprache: Englisch

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Mountains in the Greenhouse : Climate Change and the Mountains of the Western U.S.A. (2020)

McKenzie, Donald.

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Environment. ; Ecology . ; Ecosystems. ; Environmental Sciences. ; Terrestial Ecology.

Beschreibung / Inhaltsverzeichnis: Chapter1.Introduction: What Persists, what Changes -- Chapter2.The mountains -- Chapter3.It's getting warm down here -- Chapter4.Water towers of the west -- Chapter5.Trees, forests, and carbon -- Chapter6.Ecological disturbance -- Chapter7.Creatures great and small -- Chapter8.Extremes, Thresholds, Vulnerabilities -- Chapter9.Mountains and People in a Warming World.

Kurzfassung: This book is written for general readers with an interest in science, and offers the tools and ideas for understanding how climate change will affect mountains of the American West. A major goal of the book is to provide material that will not become quickly outdated, and it does so by conveying its topics through constants in ecological science that will remain unchanged and scientifically sound. The book is timely in its potential to be a long-term contribution, and is designed to inform the public about climate change in mountains accessibly and intelligibly. The major themes of the book include: 1) mountains of the American West as natural experiments that can distinguish the effects of climate change because they have been relatively free from human-caused changes, 2) mountains as regions with unique sensitivities that may change more rapidly than the Earth as a whole and foreshadow the nature and magnitude of change elsewhere, and 3) different interacting components of ecosystems in the face of a changing climate, including forest growth and mortality, ecological disturbance, and mountain hydrology. Readers will learn how these changes and interactions in mountains illuminate the complexity of ecological changes in other contexts around the world.

Materialart: Online-Ressource

Seiten: XV, 235 p. 53 illus., 49 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030424329

URL: https://doi.org/10.1007/978-3-030-42432-9

DOI: 10.1007/978-3-030-42432-9

DDC: 577

Sprache: Englisch

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Mare Plasticum - The Plastic Sea : Combatting Plastic Pollution Through Science and Art (2020)

Streit-Bianchi, Marilena. [editor.] ; Cimadevila, Margarita. [editor.] ; Trettnak, Wolfgang. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Ecology . ; Pollution. ; Environment. ; Water. ; Hydrology. ; Biophysics. ; Arts. ; Ecology. ; Pollution. ; Environmental Sciences. ; Water. ; Biophysics. ; Arts.

Beschreibung / Inhaltsverzeichnis: Chapter 1. The Exhibition MARE PLASTICUM: Art and Science for the Environment -- Chapter 2. A Brief History of Plastics -- Chapter 3. Plastics and Microplastics: Impacts in the Marine Environment -- Chapter 4. The (Un)Natural History of the “Plastisphere”, A New Marine Ecosystem -- Chapter 5. Polarquest 2018 Expedition: Plastic Debris at 82°07’ North -- Chapter 6. The Impact of Marine Litter in Marine Protected Areas (MPAs) in the Mediterranean Sea: How Can We Protect MPAs? -- Chapter 7. Plastic in China: A Short History of a Crisis -- Chapter 8. "Down by the River": (Micro-) Plastic Pollution of Running Freshwaters with Special Emphasis on the Austrian Danube -- Chapter 9. Small Plastic Wastes in Soils: What Is Our Real Perception of the Problem? -- Chapter 10. Europe's Move Towards Plastic-Free Ocean -- Chapter 11. Plastic Pollution in the Oceans - A Systemic Analysis—Status Quo and Possible Sustainable Solutions -- Chapter 12. Toys for the Winter -- Chapter 13. "The Bottlenose Dolphin” (An Eco-comic).

Kurzfassung: This book, written by a multidisciplinary team of authors comprising scientists, artists and communicators, explores one of the most pressing issues of our time – the menace plastics pose to marine environments and organisms. It takes readers on a journey that begins on the beaches of Galicia, where the beach litter formed the starting point for an exhibition that combines art and science to alert the audience to the urgent need for action. The journey culminates with a short “plastic story”, which reveals a disturbing vision of the future significance of plastics for humans, and an example of how comics can deliver information to a younger audience. Along the way there is plenty of fascinating science, such as insights into the impacts of plastics and microplastics; the new marine ecosystem, known as the “plastisphere”; and the current status of the oceans, from the Arctic to the Mediterranean. The book also explores the historical developments; sustainable solutions, including the use of circular economy methodologies; and protective measures, like those being tried in China and the Far East. Lastly, it describes the role played by rivers as transport vectors for plastic, with special reference to the Danube, and to complete the picture, since most of the plastic is of terrestrial origin, it investigates problems related to microplastics in soils.

Materialart: Online-Ressource

Seiten: XV, 252 p. 89 illus., 75 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030389451

URL: https://doi.org/10.1007/978-3-030-38945-1

DOI: 10.1007/978-3-030-38945-1

DDC: 577

Sprache: Englisch

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Tumor Microenvironment : Hematopoietic Cells – Part B (2020)

Birbrair, Alexander. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Cancer. ; Hematopoietic system. ; Cytology. ; Cancer Microenvironment. ; Haematopoietic System. ; Cell Biology. ; Cancer Biology.

Beschreibung / Inhaltsverzeichnis: Eosinophils in the tumor microenvironment -- Dendritic cells in the tumor microenvironment -- Resident memory T cells in the tumor microenvironment -- NK cells in the tumor microenvironment -- γδ T cells in tumor microenvironment -- Regulatory T Cells in the Tumor Microenvironment -- The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche) -- Langerhans cells in the tumor microenvironment -- Mast cells in the tumor microenvironment -- B cells in the gastrointestinal tumor microenvironment with a focus on pancreatic cancer: opportunities for precision medicine? -- Microglia in the Brain Tumor Microenvironment -- Index.

Kurzfassung: Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include eosinophils, NK cells, γδ T cells, regulatory T Cells, Langerhans cells, hematopoietic stem cells, Mast cells, B cells and Microglia, and more. Taken alongside its companion volumes, Tumor Microenvironment: Hematopoietic Cells – Part B updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Materialart: Online-Ressource

Seiten: XIV, 215 p. 26 illus., 24 illus. in color. , online resource.

Ausgabe: 1st ed. 2020.

ISBN: 9783030492700

Serie: Advances in Experimental Medicine and Biology, 1273

URL: https://doi.org/10.1007/978-3-030-49270-0

DOI: 10.1007/978-3-030-49270-0

DDC: 571.978

Sprache: Englisch

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Role of Exosomes in Biological Communication Systems (2021)

Alzahrani, Faisal A. [editor.] ; Saadeldin, Islam M. [editor.]

Singapore :Springer Nature Singapore :

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Schlagwort(e): Cancer. ; Human physiology. ; Diseases. ; Oncology. ; Regenerative medicine. ; Cancer Biology. ; Human Physiology. ; Diseases. ; Oncology. ; Regenerative Medicine and Tissue Engineering.

Beschreibung / Inhaltsverzeichnis: Chapter 1. Isolation and characterization of extracellular vesicles: classical and modern approaches -- Chapter 2. Characterization and fine structure of exosomes -- Chapter 3. Extracellular vesicles mediate the embryonic-maternal paracrine communication -- Chapter 4. The interplay between oviduct-derived exosomes and cumulus-oocyte complexes -- Chapter 5. The interplay between exosomes and spermatozoa -- Chapter 6. Mesenchymal stem cell-derived exosomes and regenerative medicine -- Chapter 7. Therapeutic Potential of Mesenchymal Stem/Stromal Cell Derived-Exosomes -- Chapter 8. Exosomes in Neurodegenerative Disorders -- Chapter 9. Differential expression of exosomal microRNAs in neurodegenerative diseases -- Chapter 10. Urinary exosomes as a possible source of kidney disease biomarkers -- Chapter 11. Extracellular vesicles as potential therapeutic targets and biomarkers for liver disease -- Chapter 12. Implications of extracellular vesicles in blood protozoan parasitic diseases -- Chapter 13. Cancer cells-derived Exosomes and Metastasis -- Chapter 14. Extracellular vesicles and integrins: partners in cancer progression -- Chapter 15. Exosomes: the crucial element in the prostate cancer -- Chapter 16. Exosomal microRNAs: Potential Biomarkers for Cancer Diagnosis, Treatment Response, and Prognosis -- Chapter 17. Exosomes in drug delivery -- Chapter 18. Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems.

Kurzfassung: This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.

Materialart: Online-Ressource

Seiten: XII, 373 p. 34 illus., 30 illus. in color. , online resource.

Ausgabe: 1st ed. 2021.

ISBN: 9789811565991

URL: https://doi.org/10.1007/978-981-15-6599-1

DOI: 10.1007/978-981-15-6599-1

DDC: 571.978

Sprache: Englisch

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Methods to Study Litter Decomposition : A Practical Guide (2020)

Bärlocher, Felix. [editor.] ; Gessner, Mark O. [editor.] ; Graça, Manuel A.S. [editor.]

Cham :Springer International Publishing :

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Schlagwort(e): Biotic communities. ; Microbial ecology. ; Freshwater ecology. ; Marine ecology. ; Biogeography. ; Biodiversity. ; Biology Technique. ; Ecosystems. ; Microbial Ecology. ; Freshwater and Marine Ecology. ; Biogeosciences. ; Biodiversity. ; Biological Techniques.

Beschreibung / Inhaltsverzeichnis: Part 1. Litter dynamics: chapter 1. Litter Input (Arturo Elosegi & Jesús Pozo) -- Chapter 2. Leaf Retention (Arturo Elosegi) -- chapter 3. Manipulating Litter Retention in Streams (Michael Dobson) -- chapter 4. Coarse Benthic Organic Matter (Jesús Pozo & Arturo Elosegi) -- chapter5. Leaching (Felix Bärlocher) -- Chapter 6. Leaf Mass Loss Estimated by the Litter-Bag Technique (Felix Bärlocher) -- Chapter7. Determining Litter Mass Loss by the Plant Tagging Approach (Kevin A. Kuehn & Mark O. Gessner) -- Chapter 8. Wood Decomposition (Arturo Elosegi, Maite Arroita & Libe Solagaistua) -- Chapter9. Decomposition of Fine Particulate Organic Matter (Yoshimura Chihiro) -- Chapter10. Coarse Particulate Organic Matter Budgets (Jesús Pozo & Jon Molinero) -- Part 2. Chemical and Physical Leaf Properties. Chapter11. Total Phosphorus, Nitrogen, and Carbon in Leaf Litter (Mogens R. Flindt, Ana I. Lillebø, Javier Pérez & Verónica Ferreira) -- Chapter12. Total Protein (Mark O. Baerlocher) -- Chapter13. Free Amino Acids (Shawn D. Mansfield & Mark O. Baerlocher) -- chapter14. Determination of Total Carbohydrates (Shawn D. Mansfield) -- chapter15. Determination of Soluble Carbohydrates (Letitia da Ros, Faride Unda, Shawn D. Mansfield) -- Chapter16. Total Lipids (Mark O. Gessner & Paul T. M. Neumann) -- Chapter17. Polyunsaturated Fatty Acids in Decomposing Leaf Litter (Eric Von Elert) -- Chapter18. Total Phenolics (Felix Bärlocher & Manuel A.S. Graça) -- Chapter19. Radial Diffusion Assay for Tannins (Manuel A.S. Graça & Felix Bärlocher) -- Chapter20. Acid Butanol Assay to Determine Bulk Concentrations of Condensed Tannins (Mark O. Gessner & Daniel Steiner) -- Chapter21. Lignin and Cellulose (Mark O. Gessner) -- Chapter22. Physical Litter Properties: Leaf Toughness and Tensile Strength (Manuel A.S. Graça & Martin Zimmer) -- Part 3. Microbial Decomposers. Chapter23. Techniques for Handling Ingoldian Fungi (Enrique Descals) -- Chapter24. Maintenance of Aquatic Hyphomycete Cultures (Ludmila Marvanová) -- Chapter 25. An Illustrated Key to the Common Temperate Species of Aquatic Hyphomycetes (Vladislav Gulis, Ludmila Marvanová & Enrique Descals) -- Chapter26. Sporulation by Aquatic Hyphomycetes (Felix Bärlocher) -- Chapter 27. Ergosterol as a Measure of Fungal Biomass (Mark O. Gessner) -- Chapter 28. Fungal Growth Rates and Production (Keller Suberkropp, Mark O. Gessner & Kevin A. Kuehn) -- Chapter 29. Bacterial Abundance and Biomass Determination in Plant Litter by Epifluorescence Microscopy (Nanna Buesing & Mark O. Gessner) -- Chapter 30. Growth and Production of Litter-Associated Bacteria (Nanna Buesing, Mark O. Gessner & Kevin A. Kuehn) -- Chapter 31. Isolation of Cellulose-Degrading Bacteria (Jürgen Marxsen) -- Chapter 32. ATP as a Measure of Microbial Biomass (Manuela Abelho) -- Chapter 33. Respiration of Litter-Associated Microbes and Invertebrates (Manuel A.S. Graça & Manuela Abelho) -- Part 4. Molecular Microbial Community Analyses. Chapter34. Terminal Restriction Fragment Length Polymorphism (T-Rflp) to Estimate Fungal Diversity (Liliya G. Nikolcheva & Felix Bärlocher) -- Chapter 35. Denaturing Gradient Gel Electrophoresis (DGGE) to Estimate Fungal Diversity (Liliya G. Nikolcheva & Felix Bärlocher) -- Chapter36. Quantitative Real-Time PCR (qPCR) to Estimate Molecular Fungal Abundance (Christiane Baschien & J. Steffen C. Carl) -- Chapter 37. Metabarcoding of Litter-associated Fungi and Bacteria (Sofia Duarte, Christian Wurzbacher & Sahadevan Seena) -- Chapter 38. Identifying Active Members of Litter Fungal Communities by Precursor rRNA (Martina Štursová & Petr Baldrian) -- Chapter 39. Gene Expression Analysis of Litter-Associated Fungi Using RNA-Seq (Elizabeth C. Bourne, Paul R. Johnston, Elisabeth Funk & Michael T. Monaghan) -- Chapter 40. Metaproteomics of Litter-associated Fungi (Katharina M. Keiblinger & Katharina Riedel) -- Part 5. Enzymatic Capabilities. Chapter 41. Extractellular Fungal Hydrolytic Enzyme Activity (Shawn D. Mansfield) -- chapter 42. Cellulases (Martin Zimmer) -- Chapter 43. Viscosimetric Determination of Endocellulase Activity (Björn Hendel & Jürgen Marxsen) -- Chapter 44. Fluorometric Determination of The Activity of β-Glucosidase and other Extracellular Hydrolytic Enzymes (Björn Hendel & Jürgen Marxsen) -- Chapter 45. Pectin-degrading Enzymes: Polygalacturonase and Pectin Lyase (Keller Suberkropp) -- chapter 46. Lignin-degrading Enzymes: Phenoloxidase and Peroxidase (Björn Hendel, Robert L. Sinsabaugh & Jürgen Marxsen) -- Chapter 47. Phenol Oxidation (Martin Zimmer) -- Chapter 48. Proteinase Activity: Azocoll and Thin-layer Enzyme Assay (Manuel A.S. Graça & Felix Bärlocher) -- Part 6. Litter Consumers. Chapter 49. Processing of Aquatic Invertebrates Colonizing Decomposing Litter (John S. Richardson) -- chapter 50. Identifying Stream Invertebrates as Plant Litter Consumers (Luz Boyero, Richard G. Pearson, Ricardo J. Albariño, Marcos Callisto, Francisco Correa-Araneda, Andrea C. Encalada, Marcelo Moretti, Alonso Ramírez, April Sparkman, Christopher M. Swan, Catherine M. Yule & Manuel A.S. Graça) -- chapter 51. Shredder Feeding and Growth Rates (Manuel A.S. Graça & José M. González) -- chapter 52. Feeding Preferences (Cristina Canhoto, Manuel A.S. Graça & Felix Bärlocher) -- chapter 53. Energy Budget of Shredders (Manuel A.S. Graça) -- chapter 54. The Role of Shredders in Litter Dynamics at Stream Scale (José M. González & Manuel A.S. Graça) -- Part 7. Litter Manipulations. Chapter 55. Manipulation of Leaf Litter Stoichiometry (Julio Arce-Funck, Vincent Felten, Michael Danger) -- Chapter 56. Isotopic Labelling of Leaf-litter Nitrogen (Bernd Zeller, Severine Bienaimé & Etienne Dambrine) -- Chapter 57. Decomposition and Consumption Tablets (DECOTABSs) (Gea H. van Der Lee, Ellard R. Hunting, J. Arie Vonk & Michiel H.S. Kraak) -- chapter 58. Inoculation of Leaf Litter with Aquatic Hyphomycetes (Eric Chauvet) -- Part 8. Data Analyses. Chapter 59. A Primer for Statistical Analysis (Felix Bärlocher) -- Chapter 60. Determining Temperature-normalized Decomposition Rates (Mark O. Gessner & Frank Peeters) -- Chapter 61. Biodiversity Analysis (Felix Bärlocher) -- Chapter 62. A Bioinformatics Primer for the Analysis of Illumina MiSeq Data of Litter-associated Fungi and Bacteria (Sahadevan Seena, Sofia Duarte & Christian Wurzbacher) -- Chapter 63. A Primer for Meta-Analysis (Verónica Ferreira & Felix Bärlocher).

Kurzfassung: This edited volume is an extensive collection of methods for investigating plant litter dynamics in ecosystems. Particular emphasis is placed on litter decomposition in streams and rivers. The presented methods range from analyses of chemical and physical litter properties to the taxonomic and functional characterization of microbial decomposers, both fungi and bacteria, assessments of litter-consuming invertebrates, and procedures to determine litter dynamics at the stream ecosystem level. Several chapters addressing general topics of data analysis are also included. This second edition of the book has been greatly expanded. Its now 63 chapters cover both well-established and recently elaborated techniques, some of which have not yet been applied to decomposing litter in streams. Modern molecular techniques ranging from next-generation sequencing to proteomics receive special attention among the 20 chapters that are entirely new. Numerous methods on characterizing litter consumers have also been added to fill an evident gap of the first edition. However, the basic original concept and all of the previous chapters have been retained, although most of them have been thoroughly updated. Typical contributions provide step-by-step protocols that are preceded by brief reviews of the ecological significance and the principles underlying the method. Where available, short compilations of published data have been added in overview tables to provide background information on the range of results to expect. Useful hints, a discussion of potential weaknesses, and key references are provided at the end. Hands-on material useful to implement several of the presented methods (e.g. computer code, calculation sheets) is available online. The book is written for students embarking on studies of plant litter dynamics and for established researchers wishing to expand the scope of their methodological toolbox to study litter decomposition and the microbial decomposers and invertebrates involved in the process. The primary intended audience is aquatic ecologists, since many of the methods presented in the book focus on streams and stream organisms. However, the great majority of the protocols can be easily adapted or even directly applied to coastal and terrestrial ecosystems. Consequently, they should be of equal interest to scientists investigating plant litter dynamics in habitats such as mangroves and salt-marshes, terrestrial grasslands and forests.

Materialart: Online-Ressource

Seiten: XXV, 604 p. 89 illus., 37 illus. in color. , online resource.

Ausgabe: 2nd ed. 2020.

ISBN: 9783030305154

URL: https://doi.org/10.1007/978-3-030-30515-4

DOI: 10.1007/978-3-030-30515-4

DDC: 577

Sprache: Englisch

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