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  • Books  (46)
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  • Cham :Springer International Publishing :  (46)
  • University of Virginia Library
  • Bremerhaven : Alfred-Wegener-Inst. für Polar- und Meeresforschung
  • Wabern : Federal Office of Topography, Swiss Geological Survey
  • 571.96  (46)
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  • Books  (46)
  • Maps
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  • Cham :Springer International Publishing :  (46)
  • University of Virginia Library
  • Bremerhaven : Alfred-Wegener-Inst. für Polar- und Meeresforschung
  • Wabern : Federal Office of Topography, Swiss Geological Survey
  • Singapore :Springer Nature Singapore :  (17)
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  • 1
    Online Resource
    Online Resource
    Basic and Clinical Immunology by Names : From the Biblical Time Until the Present (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medicine History. ; Medicine Research. ; Biology Research. ; Immunology. ; History of Medicine. ; Biomedical Research.
    Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Z.
    Abstract: Hundreds of eponyms are used within the field of immunology—Petri dish, Crohn’s disease, Bence Jones protein, Kupffer cells, Freund's adjuvant, Ouchterlony immunodiffusion, to name just a few—but most of us don't know much about the individuals who gave their names to these terms. Where were they born and educated, what other accomplishments are they credited with, why has history chosen to remember them, or not? This book presents the first comprehensive collection of immunologic eponyms, and through them tells the story of this fascinating field, from its earliest beginnings to present day. Organized by surname and meticulously cross-referenced and indexed, this book offers historical anecdotes and little-known facts which scientists, clinicians, students, and general readers will find captivating and memorable. A one-of-a-kind introduction to immunology that serves as both a history lesson and current reference on the diseases, treatments, and individuals who have been crucial to this field.
    Type of Medium: Online Resource
    Pages: XXVIII, 405 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031145292
    URL: https://doi.org/10.1007/978-3-031-14529-2
    DOI: 10.1007/978-3-031-14529-2
    DDC: 571.96
    Language: English
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  • 2
    Online Resource
    Online Resource
    History of Rabies in the Americas: From the Pre-Columbian to the Present, Volume I : Insights to Specific Cross-Cutting Aspects of the Disease in the Americas (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Virology. ; Medicine History. ; Veterinary medicine. ; Vaccines Biotechnology. ; Biomaterials. ; Immunology. ; Virology. ; History of Medicine. ; Veterinary Science. ; Biomaterials-Vaccines.
    Description / Table of Contents: The world in flux – the Columbian Exchange D. Domenici -- Glimpses into the past: new world contributions towards understanding the basic etiology, pathobiology & treatment of rabies, Drishya Kurup et al -- The Diversity, Evolution and Emergence of Rabies Virus in the Americas, Edward C. Holmes & Erin H. Harvey -- The ecological range and principles of wildlife rabies virus perpetuation in the Americas, Amy T. Gilbert -- Historical Laboratory Contributions Supporting Rabies Diagnosis and Disease Prevention and Control in the Americas, Susan A. Nadin-Davis, et al -- Progression from nerve tissue vaccines to recombinant biologics, H. Ertl -- Wildlife Rabies Management in the New World: Prevention, Control and Elimination in Mesocarnivores, R. Chipman et al -- Management of vampire bats and rabies: past, present, and future, Tonie Rocke & Daniel Streicker -- Conflicting Perspectives on a Rabies Outbreak in a Venezuelan Rainforest, 2007-2008, C. Briggs -- Rabies, Medicine, and Culture: Dogs, Disease, and Urban Life in the United States, 1840-1920, Jessica Wang -- Historical disparities in health: rabies surveillance, risk factors and prevention, Amira Roess et al -- The Health Economics of Rabies in the Americas: An Historical Summary and a Synthesis of the Literature, S.A. Shwiff -- Towards the elimination of canine rabies in the americas: governance of a regional program, M. Vigilato et al -- Musing Over Non-technical Criticalities of Rabies Prevention and Control in the Americas, Victor J. Del Rio Vilas & Gilberto Montibeller.
    Abstract: Rabies is one of the oldest known pathogens, is incurable, and has the highest fatality rate of all infectious diseases. The Americas is the only region with bat rabies virus, including vampire bat rabies. The region is rich in cultural references and notable for many discoveries in the field, including the current vaccine potency test, diagnostic assay, conception of oral vaccines for wildlife, the first human survivor and the first successful canine rabies program executed at a broad level. Rabies remains the most important viral zoonosis, with tens of thousands of human fatalities and tens of millions of exposures annually, which can be used to model for other pathogens, such as COVID-19. There is an international effort to eliminate human rabies caused by dogs over the next decade, and the Americas represent the primary region with the greatest proof-of-concept evidence to accomplish this goal. This two-volume set addresses the medical history and modern results of rabies in countries throughout the Americas, including the implications of and on cultural, economic, sociological, and research developments in the region. Volume I presents an overview of concepts critical to the study of rabies in the region, including evolutionary aspects, reservoir ecology and control, elimination efforts, vaccine development, and disease hallmarks and progression. It also analyzes the long-term cultural, social, and economic impacts of the disease in the Americas. .
    Type of Medium: Online Resource
    Pages: XVI, 319 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031250521
    Series Statement: Fascinating Life Sciences,
    URL: https://doi.org/10.1007/978-3-031-25052-1
    DOI: 10.1007/978-3-031-25052-1
    DDC: 571.96
    Language: English
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  • 3
    Online Resource
    Online Resource
    Food and the Immune System : Molecular Mechanisms and Nutritional Relevance in Health and Disease (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Food science. ; Nutrition   . ; Immunology. ; Food Science. ; Nutrition.
    Abstract: Nutrition is an important environmental factor for the maturation of the human immune system and essential for maintaining immunological homeostasis. Based on this, a variety of food applications with medical claims are being generated by food manufacturers worldwide in order to expand the market potential of products creating interesting linkages with other market segments, such as cosmetics and pharmaceuticals. However, in addition to the health benefits, active principles of such components often remain unexplored. This book focusses on the specific interactions between food ingredients and the immune system along the entire immune defense response. Starting from the immune barrier, through the innate and adaptive immune response, to active limitation and termination, all major mechanisms of the immune response are addressed and different biochemical, cellular and genetic interactions of components of our diet are discussed. The book presents a wealth of disease patterns for which nutritional factors are relevant and thereby provides indications for potential intervention strategies. In addition, associated food-technological aspects are discussed. Being the first of its kind, this book provides an overview of the variety of functional food components and their influence on immunological responses. Written in an accessible style, it addresses researchers, health professionals and students with different scientific backgrounds. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Type of Medium: Online Resource
    Pages: XXIII, 241 p. 73 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031115233
    URL: https://doi.org/10.1007/978-3-031-11523-3
    DOI: 10.1007/978-3-031-11523-3
    DDC: 571.96
    Language: English
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  • 4
    Online Resource
    Online Resource
    Sex and Gender Differences in Infection and Treatments for Infectious Diseases (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Internal medicine. ; Microbiology. ; Pharmacology. ; Immunology. ; Internal Medicine. ; Microbiology. ; Pharmacology.
    Description / Table of Contents: Genetics of sex differences in immunity -- The influence of sex hormones and X chromosome in immune responses -- Sex Differences in HIV Infection -- Chapter 6: Effects of Biological Sex and Pregnancy on SARS-CoV-2 Pathogenesis and Vaccine Outcomes -- Biological sex and pregnancy affect influenza pathogenesis and vaccination -- Sex and gender differences in tuberculosis pathogenesis and treatment outcomes -- Sex-Linked Differences in Malaria Risk Across the Lifespan -- Sex Difference in Amebiasis -- Sex Differential and Non-Specific Effects of Vaccines Over the Life Course -- Immunology of pregnancy and systemic consequences.
    Abstract: This fully revised and significantly expanded second edition examines sex and gender differences in the immune system's response to bacterial, viral, and parasitic infections. The volume discusses both common and distinct molecular mechanisms that mediate these differences and illustrates how responses to vaccines may differ between the sexes and in pregnant individuals. Special emphasis is placed on the interplay between hormones and the immune system in the pathogenesis of HIV, SARS-CoV-2, influenza, malaria, tuberculosis, and amebiasis. This second edition includes completely rewritten chapters as well as all new contents. This book is intended for researchers in academia and industry as well as clinicians in the fields of microbiology, immunology, and pharmacology. By expanding knowledge in sex and gender medicine as a basis for developing personalized treatment strategies, the book contributes to UN Sustainable Development Goals 3 (health and well-being) and 5 (gender equality).
    Type of Medium: Online Resource
    Pages: VI, 280 p. 14 illus., 13 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031351396
    Series Statement: Current Topics in Microbiology and Immunology, 441
    URL: https://doi.org/10.1007/978-3-031-35139-6
    DOI: 10.1007/978-3-031-35139-6
    DDC: 571.96
    Language: English
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  • 5
    Online Resource
    Online Resource
    The Marathon of the Messenger : A History of Messenger RNA Vaccines (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Biology Technique. ; Biotechnology. ; Molecular biology. ; Industrial engineering. ; Production engineering. ; Immunology. ; Biological Techniques. ; Biotechnology. ; Molecular Biology. ; Industrial and Production Engineering.
    Description / Table of Contents: Chapter 1. Introduction: The Marathon of the Messenger RNA -- Part I. Messenger RNA, an essential role and challenge -- Chapter 2. A short history of vaccination -- Chapter 3. From DNA to RNA -- Chapter 4. Messenger RNA (mRNA): from transcription to protein translation -- Chapter 5. The mechanism of viral infection -- Chapter 6. The immune response -- Part II. From preliminary studies to clinical trials -- Chapter 7. Promising studies in the 1990s -- Chapter 8. The use of mRNA - the initial technical obstacles -- Chapter 9. The birth of CureVac: the era of the pioneers -- Chapter 10. Solutions for mRNA optimization -- Chapter 11. Modified and unmodified mRNA: for what purpose? -- Chapter 12. Experiments and clinical trials conducted: the power of therapeutic mRNA -- Chapter 13. Experiments and clinical trials against infectious diseases -- Chapter 14. Experiments and clinical trials against cancer -- Chapter 15. Experiments and clinical trials carried out in other therapeutic fields -- Chapter 16. Modified mRNA versus unmodified mRNA: not just a scientific issue -- Part III. The triumph of messenger RNA -- Chapter 17. A very progressive diffusion in scientific circles -- Chapter 18. The development of future biotechs in the 2010s -- Chapter 19. The importance of intellectual property and patents -- Chapter 20. 2020: the triumph of anti-Covid mRNA vaccines -- Chapter 21. mRNA, a technology of the future.
    Abstract: The Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other – especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to this day. In the face of a prevailing single-mindedness, these researchers pushed through a new therapeutic concept and defined the biotechnological keys that would open the way to the production of therapeutic messenger RNA in the fight against cancer and viral infections. Written for a broad audience and accompanied by humorous cartoons, this book will appeal to anyone looking for scientific and historical answers about mRNA vaccines. Readers will discover not only the technical and scientific knowledge of how these vaccines work, but also the economic levers that were necessary to create this technology. This book has been written in collaboration with Dr. Steve Pascolo, former director of CureVac, and the RNA messenger expert Professor Chantal Pichon. It also features a preface by Dr. Pierre Meulien, former director of the European Union public-private partnership Innovative Medicines Initiative (IMI). This book is a translation of an original French edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Type of Medium: Online Resource
    Pages: XXIII, 202 p. 44 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031393006
    URL: https://doi.org/10.1007/978-3-031-39300-6
    DOI: 10.1007/978-3-031-39300-6
    DDC: 571.96
    Language: English
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  • 6
    Online Resource
    Online Resource
    Alternate Programmed Cell Death Signaling in Antiviral Host Defense (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical microbiology. ; Virology. ; Immunology. ; Medical Microbiology. ; Virology.
    Description / Table of Contents: Programmed Necrosis in Host Defense -- ZBP1/DAI-dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis -- Pyroptosis in Antiviral Immunity -- Manipulation of Host Cell Death Pathways by Herpes Simplex Virus -- Subversion of Programed Cell Death by Poxviruses -- Cell Killing by Reovirus: Mechanisms and Consequences -- Outcomes of RIP kinase signaling during neuroinvasive viral infection.
    Abstract: This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system. Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus. Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV) where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology.
    Type of Medium: Online Resource
    Pages: V, 174 p. 19 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031452789
    Series Statement: Current Topics in Microbiology and Immunology, 442
    URL: https://doi.org/10.1007/978-3-031-45278-9
    DOI: 10.1007/978-3-031-45278-9
    DDC: 571.96
    Language: English
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  • 7
    Online Resource
    Online Resource
    Molecular Immunology : How Science Works (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Autoimmunity. ; Inflammation. ; Immunogenetics. ; Tumors Immunological aspects. ; Immunology. ; Translational Immunology. ; Autoimmunity. ; Inflammation. ; Immunogenetics. ; Tumour Immunology.
    Description / Table of Contents: 1 Cells and tissues of the immune system -- 2 Innate immunity and inflammation -- 3 Adaptive immunity and antigen receptor diversity -- 4 B cell immunity: BCRs, antibodies and their effector functions -- 5 Antigen-presenting cells and the major histocompatibility complex -- 6 T cell immunity: TCRs and their effector functions -- 7 Immunity to bacterial pathogens and the microbiome -- 8 Immunity to viral pathogens and the virome -- 9 Tolerance and transplantation immunology -- 10 Immunological hypersensitivities: Allergy and autoimmunity -- 11 Cancer immunology.
    Abstract: This textbook aims to describe in a condensed form the essentials of molecular immunology behind bacterial infections, the microbiome, viral infections (such as influenza and COVID-19), organ transplantations, autoimmunity, allergy and tumor immunology. The book emphasizes the impact of immunology in maintaining our health and preventing disease. Our immune system protects us not only from severe consequences of infectious diseases and getting cancer, but is also able to harm us severely via sepsis, cytokine storms and anaphylactic shocks. Molecular understanding of immunology should allow the reader a more rational handling of common diseases, most of which are associated with chronic inflammation.
    Type of Medium: Online Resource
    Pages: XV, 219 p. 94 illus., 93 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040252
    URL: https://doi.org/10.1007/978-3-031-04025-2
    DOI: 10.1007/978-3-031-04025-2
    DDC: 571.96
    Language: English
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  • 8
    Online Resource
    Online Resource
    Interaction of Immune and Cancer Cells (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Tumors Immunological aspects. ; Cancer Treatment. ; Oncology. ; Tumour Immunology. ; Cancer Therapy. ; Oncology.
    Description / Table of Contents: Chapter 1: Cancer immunoediting - elimination, equilibrium and immune escape in solid tumors -- Chapter 2: Tumor – Stroma Interaction and Cancer. - Chapter 3: Tumor-infiltrating lymphocytes and their role in solid tumor progression -- Chapter 4: Tumor-associated macrophages – reasons to be cheerful, reasons to be fearful -- Chapter 5: Polymorphonuclear neutrophils and tumors: friend or foe? -- Chapter 6: Role of NK cells in tumor progression -- Chapter 7: The role of myeloid-derived suppressor cells in tumor growth and metastasis -- Chapter 8: Cancer stem cells – an ever hiding foe -- Chapter 9: Adoptive T-cell immunotherapy – Perfecting self-defenses -- Chapter 10: Monoclonal antibodies to CTLA-4 with focus on ipilimumab.
    Abstract: Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.
    Type of Medium: Online Resource
    Pages: XIV, 350 p. 22 illus., 20 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030913113
    Series Statement: Experientia Supplementum, 113
    URL: https://doi.org/10.1007/978-3-030-91311-3
    DOI: 10.1007/978-3-030-91311-3
    DDC: 571.96
    Language: English
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  • 9
    Online Resource
    Online Resource
    Essential Aspects of Immunometabolism in Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Human physiology. ; Pathology. ; Immunology. ; Human Physiology. ; Pathology.
    Description / Table of Contents: Overview of Immune response -- Metabolic Pathway: from biochemistry to bench -- Mitochondrial biogenesis and dynamics in healthy and diseases -- Epigenetic regulation of metabolic pathways -- Metabolic pathways and cells signaling -- Metabolic profile of innate and adaptive immune cells -- Metabolic sensors and immunopathology -- Obesity, metabolic syndrome and inflammation.
    Abstract: Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases. The edited volume Essentials aspects of Immunometabolism will give the readers a broad view on how metabolic pathways can influence many types of immune cells during activation, differentiation and function, in health and disease. Of note, the structure of the book was created thinking not only on the experienced immunologist but also on undergraduate and graduate students, physicians, and all members of the scientific community interested in this exciting field of research.
    Type of Medium: Online Resource
    Pages: XII, 278 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030866846
    URL: https://doi.org/10.1007/978-3-030-86684-6
    DOI: 10.1007/978-3-030-86684-6
    DDC: 571.96
    Language: English
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  • 10
    Online Resource
    Online Resource
    Emerging Modalities in Mitigation of Antimicrobial Resistance (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Immune response. ; Pathogenic microorganisms. ; Natural immunity. ; Biotechnology. ; Immunology. ; Antimicrobial Responses. ; Innate Immunity. ; Biotechnology.
    Description / Table of Contents: 1. Antimicrobials in livestock production and its cross-domain dynamics -- 2. Antibiotics and resistance in environment -- 3. Antimicrobials in agriculture and its implications in antimicrobial resistance -- 4. Modern diagnostic tools for rapid detection of multidrug resistance -- 5. The use of antimicrobials in agriculture and socio-economic considerations in a global world -- 6. Epidemiology of microbial infections -- 7. Socioeconomic impact of antimicrobial resistance and their integrated mitigation by One Health approach -- 8. Regulations in antimicrobial drug development: Challenges, and new incentives -- 9. New insights into and updates on antimicrobial agents -- 10. Polyphenols as emerging antimicrobial agents -- 11. Antimicrobial peptides and small molecules as antibiotics substitute -- 12. Molecular mechanisms of antimicrobial resistance in S. aureus biofilms -- 13. Antimicrobial resistance: Meaning and developing realization -- 14. Chemical diversity in fungi: strategies to mitigate antimicrobial resistance -- 15. Phage therapy as an alternative treatment in the fight against AMR: Real-world problems and possible futures -- 16. Omics and in-silico approaches in the surveillance and monitoring of antimicrobial resistance -- 17. Antimicrobial activity of bioactive compounds (Thymoquinone & Eugenol) and its nanoformulations therapeutic potential -- 18. Nanoparticles as a future alternative against multiple drug resistance -- 19. Nano-cargos boarded defensins to combat multi-drug resistance -- 20. Implementation of nano-vehicles to disguise and fight multi-drug resistance -- 21. Silver nanoparticles as potent multi-drug resistant in-corporants in biomedicine -- 22. Role of gold nanoparticles against bacterial multidrug resistance (MDR): An emerging therapeutic revolution -- 23. Carbon nanoparticles: A potential cost-effective approach to counter antimicrobial resistance -- 24. Antimicrobial interfaces as augmentative strategy against antimicrobial resistance -- 25. Nano-Strategies against rising antimicrobial resistance (AMR): Metallic nanoparticles as nano-weapon. .
    Abstract: This book provides an overview of cutting-edge and next-generation research and technologies for combating antimicrobial resistance. Antibiotic-resistant infections are projected to cause 10 million deaths annually by the year 2050. A sustainable, unified approach by researchers, practitioners, policymakers, and the public is urgently needed to stem this trend. This book aims to provide a comprehensive summary of current and future-facing efforts to mitigate the threat of AMR through a One-Health approach. This book is a valuable resource for students, researchers, policymakers, and the public about AMR and novel strategies to combat AMR.
    Type of Medium: Online Resource
    Pages: XII, 577 p. 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030841263
    URL: https://doi.org/10.1007/978-3-030-84126-3
    DOI: 10.1007/978-3-030-84126-3
    DDC: 571.96
    Language: English
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  • 11
    Online Resource
    Online Resource
    Chikungunya Virus (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Pharmacology. ; Virology. ; Immunology. ; Pharmacology. ; Virology.
    Description / Table of Contents: Preface -- Molecular Virology of Chikungunya Virus -- Understanding molecular pathogenesis with chikungunya virus research tools -- Chronic Chikungunya Virus Disease -- Chikungunya Virus Vaccines: Platforms, Progress, and Challenges -- Small Molecule Inhibitors Targeting Chikungunya Virus.
    Abstract: This book provides readers with a collection of latest reviews written by Chikungunya virus (CHIKV) research leaders who cover topics related to CHIKV replication, advances in CHIKV research reagents and model system development, as well as the pathogenesis of chronic CHIKV disease. Moreover, the volume updates on recent progress in the development of therapeutics and vaccines for treatment and prevention of CHIKV-induced disease. Chikungunya virus (CHIKV) is a mosquito-borne pathogen that has re-emerged to become a significant global disease threat. Although CHIKV has historically been associated with localized outbreaks of debilitating polyarthralgia in Africa and Asia, factors such as increased global travel and viral adaptation to new mosquito vectors have led to the introduction and spread of CHIKV in new regions of the world, including the Americas. The re-emergence of CHIKV has stimulated significant interest both in understanding the biology of CHIKV and in the development of medical countermeasures against the virus.
    Type of Medium: Online Resource
    Pages: XI, 139 p. 10 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030906108
    Series Statement: Current Topics in Microbiology and Immunology, 435
    URL: https://doi.org/10.1007/978-3-030-90610-8
    DOI: 10.1007/978-3-030-90610-8
    DDC: 571.96
    Language: English
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  • 12
    Online Resource
    Online Resource
    Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Inflammation. ; Autoimmunity. ; Allergy. ; Immunology. ; Inflammation. ; Autoimmunity. ; Allergology.
    Description / Table of Contents: Chapter 1. From observing children in traditional upbringing to concepts of health -- Chapter 2. Human evolution, microorganisms, socioeconomic status and reconciling necessary microbial exposures with essential hygiene -- Chapter 3. Biodiversity, microbiomes, and human health -- Chapter 4. Regulation of host immunity by the gut microbiota -- Chapter 5. The gut microbiota and host metabolism -- Chapter 6. The impacts of the microbiota on animal development and physiology -- Chapter 7. The development of the gut microbiota in childhood, and its distortion by lifestyle changes -- Chapter 8. Distortion of the microbiota of the natural environment by human activities -- Chapter 9. The nature and functions of vertebrate skin microbiota -- Chapter 10. The influence of the microbiota on brain structure and function: Implications for stress-related neuropsychiatric disorders -- Chapter 11. Neurodegenerative diseases and the gut microbiota -- Chapter 12. Clinical application of the biodiversity hypothesis in the management of allergic disorders. .
    Abstract: This edited collection of 12 chapters by research workers from a wide range of disciplines resolves the confusion that currently surrounds the “hygiene hypothesis” by considering the human need for exposure to microorganisms from an evolutionary point of view. The book explains why we evolved a requirement for exposure to microbiota from our mothers, from other people, and from the natural environment. It also explains the physiological roles of these exposures, what goes wrong when the exposures are distorted and how human lifestyles and activities, including degradation of the natural environment, are leading to this distortion. Particular attention is given to the range of pathologies associated with inappropriate microbial exposures and inappropriate colonization, including immunoregulatory problems such as allergies and autoimmunity, metabolic problems such as obesity and diabetes, and problems of central nervous system function and neurodegeneration. This book is of profound relevance to most medical disciplines, but also to those concerned with preserving the natural environment and with developing healthier urbanisation.
    Type of Medium: Online Resource
    Pages: X, 414 p. 46 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030910518
    Series Statement: Progress in Inflammation Research, 89
    URL: https://doi.org/10.1007/978-3-030-91051-8
    DOI: 10.1007/978-3-030-91051-8
    DDC: 571.96
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  • 13
    Online Resource
    Online Resource
    mRNA Vaccines (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Pharmacology. ; Internal medicine. ; Clinical biochemistry. ; Immunology. ; Pharmacology. ; Internal Medicine. ; Medical Biochemistry.
    Description / Table of Contents: Preface -- mRNA-based vaccines and mode of action -- Self-Amplifying mRNA-Based Vaccine Technology and its Mode of Action -- Formulation and Delivery Technologies for mRNA Vaccines -- Messenger RNA-based vaccines against infectious diseases -- Emerge gate for Therapeutics applications of mRNA based drug -- Clinical Development of mRNA Vaccines: Challenges and Opportunities -- Regulatory Considerations on the Development of mRNA Vaccines.
    Abstract: The formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume. The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies. Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches. Consequently, the development progress of the technology, particularly on production, capabilities, and clinical development is reviewed. Topics on safety, regulatory issues, and possible challenges to the mRNA vaccination approach round off this book. Thanks to their high potency, the prospect for generic, low-cost manufacturing processes, and entirely synthetic nature, the future for mRNA vaccines is highly promising. Importantly, mRNA vaccines have the potential to minimize the time between pathogen identification and vaccine release with a huge impact on public health. As the mRNA-based vaccination technology has been progressing rapidly, the book is intended to be an end-to-end review series, covering everything from basic RNA biology and preclinical studies to the manufacturing strategy, clinical development and regulatory approval. It provides established RNA researchers and developers with updates on the latest advancements in the field and allows for a quick but comprehensive overview of this transformative technology, its application, and future potential.
    Type of Medium: Online Resource
    Pages: XI, 205 p. 8 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031180705
    Series Statement: Current Topics in Microbiology and Immunology, 437
    URL: https://doi.org/10.1007/978-3-031-18070-5
    DOI: 10.1007/978-3-031-18070-5
    DDC: 571.96
    Language: English
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  • 14
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    Online Resource
    Healthy Longevity and Immune System (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Aging. ; Neurosciences. ; Nutrition   . ; Medical sciences. ; Immunology. ; Ageing. ; Neuroscience. ; Nutrition. ; Health Sciences.
    Description / Table of Contents: Introduction -- Changes in primary and secondary lymphoid organs (bone marrow, thymus, lymph nodes, spleen) -- Immune barriers (skin, mucosa) -- Innate immunity (neutrophils, monocytes, macrophages) -- Adaptive immunity (T and B lymphocytes: naïve, effector and memory phenotypes and functions) -- ReIntroduction -- Changes in primary and secondary lymphoid organs (bone marrow, thymus, lymph nodes, spleen) -- Immune barriers (skin, mucosa) -- Innate immunity (neutrophils, monocytes, macrophages) -- Adaptive immunity (T and B lymphocytes: naïve, effector and memory phenotypes and functions) -- Regulatory/suppressive cells (Treg, MDSC) -- Infections - Flu, pneumonia, COVID -- Vaccine responses -- Cancer -- Neurodegenerative disease -- Lifestyle/Interventions(physical activity, nutrition, supplements). .
    Abstract: This book presents studies of the main conditions that affect health and well-being of old people. Considering the present scenario of COVID-19, the effects of this viral infection on individuals older than 65 years are also discussed. The content enables professionals of health and government for the present and future actions in this important area. Readers go through the changes occurring in organs and tissues that can interfere with susceptibility to infections, low response to vaccines, cancer, and loss of cognition during the aging process. A discussion of the central role played by the immune system in the age-related diseases and how the immunity can be impaired during the ageing process is presented. Possibilities to circumvent these conditions via healthy habits in diet, physical exercise, and new pharmacological interventions are part of the content. This book discusses how human healthy longevity is dependent, at least in part, of a functional immune system. Chapters were written for researchers in the field of aging and is especially suited for those interested in the study of immunosenescence and inflammaging affecting the health of old individuals.
    Type of Medium: Online Resource
    Pages: X, 199 p. 10 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030875329
    Series Statement: Healthy Ageing and Longevity, 16
    URL: https://doi.org/10.1007/978-3-030-87532-9
    DOI: 10.1007/978-3-030-87532-9
    DDC: 571.96
    Language: English
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  • 15
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    Online Resource
    PI3K and AKT Isoforms in Immunity : Mechanisms and Therapeutic Opportunities (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Immune system. ; Cellular signal transduction. ; Cytology. ; Autoimmunity. ; Immunospecificity. ; Immunology. ; Immune Cell Signalling. ; Cell Biology. ; Autoimmunity. ; Adaptive Immunity.
    Description / Table of Contents: Class I PI3K biology -- Class II PI3K biology -- Class III PI3K biology -- PTEN in immunity -- PHLPP Signaling in Immune Cells -- PHLPP Signaling in Immune Cells -- PI3K isoforms in cell signalling and innate immune cell responses -- AKT isoforms in macrophage activation, polarization and survival -- Control of CD4+ T cell Differentiation and Function by PI3K isoforms. -- PI3K isoforms in CD8+ T cell development and function -- PI3K isoforms in B cells -- PI3K isoform signalling in platelets -- PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection -- PI3K and AKT at the Interface of Signaling and Metabolism -- The Role of PI3K Isoforms in Autoimmune Disease -- AKT Isoforms in the Immune Response in Cancer -- PI3K isoform immunotherapy for solid tumours -- PI3K targeting in non-solid cancer -- AKT isoforms as a target in cancer and immunotherapy -- Developing PI3K Inhibitors for Respiratory Diseases.
    Abstract: This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
    Type of Medium: Online Resource
    Pages: VII, 466 p. 42 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065668
    Series Statement: Current Topics in Microbiology and Immunology, 436
    URL: https://doi.org/10.1007/978-3-031-06566-8
    DOI: 10.1007/978-3-031-06566-8
    DDC: 571.96
    Language: English
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  • 16
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    Online Resource
    Primary and Secondary Immunodeficiency : A Case-Based Guide to Evaluation and Management (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Rheumatology. ; Diseases. ; Hematology. ; Oncology. ; Primary care (Medicine). ; Immunology. ; Rheumatology. ; Diseases. ; Hematology. ; Oncology. ; Primary Care Medicine.
    Description / Table of Contents: Chapter 1. Overview of Immunodeficiency -- Part I. B-Lymphocyte Immunodeficiency -- Chapter 2. Common Variable Immunodeficiency, Hypogammaglobulinemia, and Specific Antibody Deficiency -- Chapter 3. Agammaglobulinemia -- Chapter 4. Class Switch Defects -- Chapter 5. Transient Immunodeficiency of Infancy -- Chapter 6. Selective Isotype Immunodeficiency -- Chapter 7. Common Variable Immunodeficiency Disorders-like Disorders -- Part II. T-Cell Immunodeficiency -- Chapter 8. Severe Combined Immunodeficiency -- Chapter 9. Idiopathic CD4 Lymphopenia -- Chapter 10. Hyper IgE Syndrome -- Chapter 11. Genetic Syndromes with Associated Immunodeficiencies -- Part III. Immune Dysregulation Syndromes -- Chapter 12. Autoimmune Lymphoproliferative Syndrome -- Chapter 13. Auto-inflammatory Syndromes -- Chapter 14. Immune Dysregulation Leading to Autoimmunity -- Chapter 15. Dendritic Cells in Primary Immunodeficiency -- Part IV. Innate Immune Defects -- Chapter 16. Congenital Neutropenia and Migration Defects -- Chapter 17. Chronic Granulomatous Disease -- Chapter 18. Primary Immunodeficiencies of Complement -- Chapter 19. Natural Killer Cell Defects -- Chapter 20. Mucocutaneous Candidiasis -- Part V. Secondary Immunodeficiency -- Chapter 21. Immunodeficiency Secondary to Malignancies and Biologics -- Chapter 22. Immunodeficiency Secondary to Prematurity, Pregnancy, and Aging -- Chapter 23. Vaccinations in Primary and Secondary Immunodeficiencies Including Asplenia.
    Abstract: This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects. They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. Primary and Secondary Immunodeficiency will be an excellent resource for practicing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.
    Type of Medium: Online Resource
    Pages: XI, 417 p. 34 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571573
    URL: https://doi.org/10.1007/978-3-030-57157-3
    DOI: 10.1007/978-3-030-57157-3
    DDC: 571.96
    Language: English
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  • 17
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    Lung Inflammation in Health and Disease, Volume II (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Human physiology. ; Medicine Research. ; Biology Research. ; Respiratory organs Diseases. ; Immunology. ; Human Physiology. ; Biomedical Research. ; Pneumology.
    Description / Table of Contents: 1. Can GPCRs be targeted to control inflammation in asthma? -- 2. Cellular and molecular processes in pulmonary hypertension -- 3. INFLAMMATORY PATHWAYS IN SARCOIDOSIS -- 4. Innate Immune Responses and Pulmonary Diseases -- 5. Interstitial Lung Disease associated with Connective Tissue Diseases -- 6. Molecular mechanisms of vascular damage during lung injury -- 7. Neurotrophin Regulation and Signaling in Airway Smooth Muscle -- 8. Novel Thoracic MRI approaches for the assessment of pulmonary physiology and inflammation -- 9. Overview on Interactive Role of Inflammation, Reactive Oxygen Species and Calcium signaling in Asthma, COPD and Pulmonary Hypertension -- 10. Protein S-palmitoylation and lung diseases -- 11. Redox role of ROS and inflammation in pulmonary diseases -- 12. Semaphorin3E/PlexinD1 axis in asthma: what we know so far -- 13. Serine protease inhibitors to treat lung inflammatory diseases -- 14. Sex and Gender Differences in Lung Disease -- 15. Sex hormones and lung inflammation -- 16. Synopsis of Clinical Acute Respiratory Distress Syndrome (ARDS).
    Abstract: Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.
    Type of Medium: Online Resource
    Pages: XVI, 384 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030687489
    Series Statement: Advances in Experimental Medicine and Biology, 1304
    URL: https://doi.org/10.1007/978-3-030-68748-9
    DOI: 10.1007/978-3-030-68748-9
    DDC: 571.96
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  • 18
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    Neurocognitive Complications of HIV-Infection : Neuropathogenesis to Implications for Clinical Practice (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Neurosciences. ; Virology. ; Immunology. ; Neuroscience. ; Virology.
    Description / Table of Contents: I. Neuropathogenesis and Biomarkers -- New Potential Axes of HIV Neuropathogenesis with Relevance to Biomarkers and Treatment -- Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection -- Inflammatory Mechanisms and Cascades Contributing to Neurocognitive Impairment in HIV/AIDS -- Neuroimaging Advances in Diagnosis and Differentiation of HIV, Comorbidities, and Aging in the cART Era -- II. Neurocognitive Impairments in Low-, Middle- and High-Income Countries – Incidence / Prevalence and Contexts -- Neurocognitive Complications of Pediatric HIV Infections -- Neurocognitive Complications of HIV Infection in Women: Insights from the WIHS Cohort -- Cultural Neuropsychology Considerations in the Diagnosis of HIV- Associated Neurocognitive Disorders -- Neurocognitive Complications of HIV Infection in Low-Income Countries -- Deep Phenotyping of HIV Neurocognitive Complications Among Individuals Residing in High-Income Countries -- Reliably Measuring Cognitive Change in the Era of Chronic HIV Infection and Chronic HIV-Associated Neurocognitive Disorders -- III. Comorbidities and Complications -- Geriatric Syndromes in People Living with HIV Associated with Ageing and Increasing Comorbidities: Implications for Neurocognitive Complications of HIV Infection -- Conceptualizing and Assessing Everyday Functioning in the Context of HIV-Associated Neurocognitive Disorders -- Neuropsychiatric Disorders, Emotional Disturbances, and Their Associations with HIV-Associated Neurocognitive Disorder -- Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders -- HIV-Associated Neurocognitive Disorder (HAND): Relative Risk Factors -- IV. Screening, Interventions and Clinical Management -- Screening for HIV-Associated Neurocognitive Disorders: Sensitivity and Specificity -- Behavioral and Physical Activity Interventions for HAND -- Targeting HIV-Related Neurocognitive Impairments with Cognitive Training Strategies: Insights from the Cognitive Aging Literature -- Clinical Treatment Options and Randomized Clinical Trials for Neurocognitive Complications of HIV Infection: Combination Antiretroviral Therapy, Central Nervous System Penetration Effectiveness, and Adjuvants.
    Abstract: This volume aims at presenting the latest international research and discoveries in the neurocognitive aspects and complications in HIV/AIDS, and how this understanding can shape and inform how we think about clinical practice and patient care in HIV/AIDS as well as lead to a better understanding of the underlying neuropathogenesis. The chapter, "Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders", of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: XVII, 545 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030807597
    Series Statement: Current Topics in Behavioral Neurosciences, 50
    URL: https://doi.org/10.1007/978-3-030-80759-7
    DOI: 10.1007/978-3-030-80759-7
    DDC: 571.96
    Language: English
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  • 19
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    Online Resource
    Antibody Glycosylation (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Pharmacology. ; Biochemical markers. ; Analytical chemistry. ; Biotechnology. ; Immunology. ; Pharmacology. ; Biomarkers. ; Bioanalytical Chemistry. ; Biotechnology.
    Description / Table of Contents: Microheterogeneity of antibody molecules -- Part I: Analytical Methods -- Lectin and LC based methods for immunoglobulin (G) glycosylation analysis -- Mass spectrometry-based methods for immunoglobulin G N-glycosylation analysis -- CE based methods for Ig(G) glycosylation analysis -- Automation of Ig glycosylation analysis -- Bioinformatics in immunoglobulin glycosylation analysis -- Part II: Biosynthesis & Regulation -- N-glycan biosynthesis: Basic principles and factors affecting its outcome -- Genetic regulation of immunoglobulin G glycosylation -- Epigenetics of immunoglobulin G glycosylation -- IgG changes in aging and other inflammatory conditions -- Estrogen-driven changes in immunoglobulin G Fc glycosylation -- Part III: Effector Functions & Diseases -- Sweet rules – linking glycosylation to antibody function -- Immunoglobulin G glycosylation in diseases -- Immunoglobulin A glycosylation and its role in diseases -- Part IV: Applications -- Importance and monitoring of therapeutic immunoglobulin G glycosylation -- Glycosylation of plant-produced immunoglobulins -- The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine -- Glycosylation of antigen-specific antibodies - Perspectives on immunoglobulin G glycosylation in vaccination and immunotherapy.
    Abstract: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 591 p. 66 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030769123
    Series Statement: Experientia Supplementum, 112
    URL: https://doi.org/10.1007/978-3-030-76912-3
    DOI: 10.1007/978-3-030-76912-3
    DDC: 571.96
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  • 20
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    Inflammation and Epilepsy: New Vistas (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Neurology . ; Neurosciences. ; Diseases. ; Pharmacology. ; Immunology. ; Neurology. ; Neuroscience. ; Diseases. ; Pharmacology.
    Description / Table of Contents: Pro and Anti-Inflammatory Neurovascular Processes in Epilepsy: A Fragile and Dynamic Equilibrium -- Emerging Molecular Mechanisms of Neuroinflammation in Seizure Disorders -- Glial Mechanisms of Inflammation during Seizures -- Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction and Epilepsy -- Blood T cells and Cytokine Levels during Interictal-Ictal Transitions -- Autoantibodies, Encephalopathies and Epilepsy -- Tau Protein in Drug-Resistant Epilepsy and Cognitive Decline -- Ketogenic Diet, Inflammation and Epilepsy -- Role of Regulatory T cells in Epilepsy -- Inflammation at the Neurovascular Unit in Post-Traumatic Epilepsy.
    Abstract: This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.
    Type of Medium: Online Resource
    Pages: VIII, 237 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030674038
    Series Statement: Progress in Inflammation Research, 88
    URL: https://doi.org/10.1007/978-3-030-67403-8
    DOI: 10.1007/978-3-030-67403-8
    DDC: 571.96
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  • 21
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    Amino Acids in Nutrition and Health : Amino Acids in the Nutrition of Companion, Zoo and Farm Animals (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical sciences. ; Cytology. ; Biochemistry. ; Nutrition   . ; Immunology. ; Health Sciences. ; Cell Biology. ; Biochemistry. ; Nutrition.
    Description / Table of Contents: Prelims -- One-carbon metabolism and development of the conceptus during pregnancy: Lessons from studies with sheep and pigs -- Cell-specific expression of enzymes for serine biosynthesis and glutaminolysis in farm animals -- Amino acids in beef cattle nutrition and production (author to be identified) -- Amino acid nutrition and reproductive performance in ruminants -- Amino acids in the nutrition and production of sheep and goats -- Amino acids in swine nutrition and production -- Amino acid nutrition and metabolism in chickens -- Nutrition and functions of amino acids in fish -- Nutrition and functions of amino acids in aquatic crustaceans -- Amino acids in dog nutrition and health -- Amino acids in the nutrition, metabolism, and health of domestic cats -- Amino acid nutrition for optimum growth, development, reproduction, and health of zoo animals.
    Abstract: This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in companion (dogs and cats), zoo (carnivores, herbivores, and omnivores), and farm (including cattle, pigs, sheep, goats, chickens, fish, and crustaceans) animals. It enables readers to understand the crucial roles of amino acids and their metabolites in the growth, development, health, and metabolic diseases of these animals. Readers will learn from well-written chapters that amino acids are not only the building blocks of protein but are also signaling molecules and key regulators of gene expression and whole body homeostasis in companion, domestic, aquatic, and captive animals. The book also provides new and useful information on the optimum requirements of the animals for dietary amino acids. This knowledge will guide nutritional practices and daily management to improve the health and survival of all species and to enhance the productivity of livestock, poultry, and aquaculture enterprises worldwide to produce high-quality protein for human consumption. Editor of this volume is an internationally recognized expert in the biochemistry, nutrition and physiology of amino acids. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals and pet owners, as well as undergraduate and graduate students in animal science, aquaculture, zoology, wildlife, veterinary medicine, biology, biochemistry, food science, nutrition, pharmacology, physiology, toxicology, and other related disciplines. In addition, all chapters provide general and specific references to amino acid nutrition and metabolism for researchers and practitioners in animal agriculture, aquaculture, zoos, biomedicine, and plant science, and for government policy makers. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VI, 256 p. 36 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030544621
    Series Statement: Advances in Experimental Medicine and Biology, 1285
    URL: https://doi.org/10.1007/978-3-030-54462-1
    DOI: 10.1007/978-3-030-54462-1
    DDC: 571.96
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  • 22
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    Amino Acids in Nutrition and Health : Amino Acids in Gene Expression, Metabolic Regulation, and Exercising Performance (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical sciences. ; Cytology. ; Biochemistry. ; Nutrition   . ; Immunology. ; Health Sciences. ; Cell Biology. ; Biochemistry. ; Nutrition.
    Description / Table of Contents: Chapter 1: Regulation of Gene Expression by Amino Acids in Animal Cells -- Chapter 2: Amino acids in cell signaling: regulation and function -- Chapter 3: Amino Acids in Endoplasmic Reticulum Stress and Redox Signaling -- Chapter 4: Amino Acids in Autophagy: Regulation and Function -- Chapter 5: Oxidation of Energy Substrates in Tissues of Fish: Metabolic Significance and Implications for Gene Expression and Carcinogenesis -- Chapter 6: Arginine, Agmatine and Polyamines: Key Regulators of Conceptus Development in Mammals -- Chapter 7: Interorgan Metabolism of Glutamate and Glutamine in Poultry -- Chapter 8: Interorgan Metabolism of Amino Acids in Health and Disease -- Chapter 9: Amino Acids and Their Metabolites for Improving Human Exercising Performance -- Chapter 10: Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans -- Chapter 11: Composition of Amino Acids in Foodstuffs for Humans and Animals -- Chapter 12: Dietary Intakes of Amino Acids and Other Nutrients by Adult Humans.
    Abstract: This book explains about amino acids (AAs) which are not only building blocks of protein, but are also signaling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular-weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds, and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole-body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health, and well-being of individuals.
    Type of Medium: Online Resource
    Pages: VI, 227 p. 34 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030741808
    Series Statement: Advances in Experimental Medicine and Biology, 1332
    URL: https://doi.org/10.1007/978-3-030-74180-8
    DOI: 10.1007/978-3-030-74180-8
    DDC: 571.96
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  • 23
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    Western Blotting for the Non-Expert (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Immunology. ; Biomedical Research. ; Biotechnology.
    Description / Table of Contents: Western blotting: How it began -- 2. Basics of Western Blotting -- 3.Basic Calculations in Western Blotting -- 4.Choosing The Right Antibody For Western Blotting -- 5. Sample Preparation -- 6. Blocking membranes at places that do not have transferred proteins -- 7. A Basic Method for Western Blotting -- 8. Trouble Shooting Western Blotting -- 9. Using Biotin to demonstrate western and dot blotting in University Practical Classes- A Guide To Instructors -- 10. Nitrocellulose Membrane Art -- 11. The Use Of A Harmless Invisible Ink To Send Secret Messages On Nitrocellulose Membranes And As A Substitute For The Harmful Radioactive Ink Used As A Marker In ECL Membrane Assays -- 12. Fingerprinting On Nitrocellulose And Polyvinylidene Difluoride Membrane -- 13. Spectrometric Determination Of Protein For Electrophoresis -- 14. Concentrating Proteins For Western Blotting -- 15. Dissolving Proteins Using Lysis Buffer -- 16. Blotting And Detecting Glycosaminoglycans -- 17. Passive Blotting From Tissue Slices -- 18. Localizing Proteins by Tissue Printing -- 19. Ultrasound Blotting -- 20. Obtaining Several Blots From A Single SDS-PAGE Gel By Passive Transfer -- 21. Diffusion Blotting From SDS-PAGE Gels Supported By Solid Plastic -- 22. Dot-Immunobinding -- 23. Simultaneous Immunoblotting Analysis With Activity Gel Electrophoresis -- 24. Protein Blotting By Centrifugation -- 25. Blotting And Immunostaining Of Multiple Antigenic Peptides -- 26. High Molecular Weight Protein Blotting Using Agarose Gel Electrophoresis -- 27. Cetyltrimethylammonium bromide PAGE And Eastern Blotting -- 28. Purification Of Autoantibodies Bound To An Autoantigen Immobilized On A Membrane Strip -- 29. Miniaturized Blotting -- 30. Affinity Immunoblotting -- 31. Transferring Coomassie Blue Stained Proteins from Polyacrylamide Gels To Transparencies -- 32. Protein Transfer From Immobilized pH Gradient Gels -- 33. SDS PAGE To Immunoblotting In Sixty Minutes -- 34. Western Blot Analysis Of Protein-DNA Complexes Formed DuringGel Shift Experiments -- 35. Electrophoretic Transfer Of High And Low Molecular Weight Proteins To Membranes Using Heat -- 36. Grid-immunoblotting -- 37. Far-western Blotting -- 38. Native Electrophoresis And Western Blot Analysis -- 39. Efficient Electroblotting Of Low Molecular Weight Protein After Staining With Coomassie -- 40. Avoiding Non-specific Binding Of Secondary Antibodies In Immunoblotting By Double-blotting -- 41.A Brief Introduction To Other Protein Blotting Methods -- 42. Quantitative Computerized Western Blotting In Detail -- 43. Common Problems In Electrophoresis.
    Abstract: This book fills the need for a simplified text covering western blotting protocols aimed not just at high school and college students, but the researcher with little to no experience in these techniques. It provides the principles, basic methodology, and tips and tricks to avoiding the common pitfalls of western blotting. The book also introduces simple protocols that can transform western blotting into a fun method, such as sending secret messages on membranes or using nitrocellulose membrane as a canvas for art. In addition to the techniques, this book also covers the history of western blotting, which originated from the development of the blotting of DNA. It then delves into the importance of protein blotting, brought to the fore by the fact that the procedure has been evolving constantly since its inception in 1979, and the fact that the scientific community is faced with a multitude of ways and means of transferring proteins to membranes.
    Type of Medium: Online Resource
    Pages: XXIII, 467 p. 611 illus., 170 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030706845
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    URL: https://doi.org/10.1007/978-3-030-70684-5
    DOI: 10.1007/978-3-030-70684-5
    DDC: 571.96
    Language: English
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  • 24
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    Online Resource
    Medical and Biomedical Updates (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Human physiology. ; Respiratory organs. ; Physiology. ; Immunology. ; Human Physiology. ; Respiratory Physiology.
    Description / Table of Contents: Role of IP3 Receptors in Shaping the Carotid Chemoreceptor Response to Hypoxia but not to Hypercapnia in the Rat Carotid Body: An Evidence Review -- The Role of Hyperbaric Oxygen Treatment for COVID-19: A Review -- Primary Immunodeficiencies - Diseases of Children and Adults: A Review -- Pneumococcal Vaccine in Adult Asthma Patients -- Immunoglobulin G Deficiency in Children with Recurrent Respiratory Infections with and without History of Allergy -- Pruritus Characteristics in Severe Atopic Dermatitis in Adult Patients -- Pathophysiological Responses to a Record-Breaking Multi-Hour Underwater Endurance Performance: A Case Study -- Respiratory Muscle Strength and Ventilatory Function Outcome: Differences between Trained Athletes and Healthy Untrained Persons -- Uroflowmetry and Altitude Hypoxia: A Report from Healthy Italian Trekkers and Nepali Porters during Himalayan Expedition -- Effects of Intraligamentary Injection of Osteogenic-Induced Gingival Fibroblasts on Cementum Thickness in the Dog Model of Tooth Root Resorption -- In-Silico Evaluation of Treatment of Periprosthetic Fractures in Elderly Patients after Hip Arthroplasty -- Appraisal of burden of caregivers to chronically rehabilitated patients with spinal cord injuries in a tertiary neurological center in Nepal.
    Abstract: This book integrates topics in basic research and clinical medicine as well as molecular and cell biology. It presents innovative advances in the field of immunodeficiency syndromes and viral/bacterial respiratory infections, including a novel hyperbaric oxygen treatment for COVID-19. A comprehensive insight is offered into the unresolved molecular pathways in chemosensing that plays a vital role in detecting insufficient tissue oxygenation, as well as in sporting accomplishments. Other articles address cardiorespiratory and humoral responses to hypoxia, the function of cementum in the repair and regeneration of teeth, and periprosthetic fractures following hip arthroplasty in the elderly. The issue of the overwhelming burdens on caregivers to spinal injury patients, damaging both health and psychosocial status, is addressed. The book promotes translation of scientific advances to the general medical practice. It will be a valuable reference for clinical healthcare professionals and researchers interested in innovative practices to improve the prevention, diagnosis, and management of diseases.
    Type of Medium: Online Resource
    Pages: VI, 131 p. 20 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030672164
    Series Statement: Clinical and Experimental Biomedicine, 1289
    URL: https://doi.org/10.1007/978-3-030-67216-4
    DOI: 10.1007/978-3-030-67216-4
    DDC: 571.96
    Language: English
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  • 25
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    Online Resource
    Mathematical, Computational and Experimental T Cell Immunology (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Bioinformatics. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Cytokine receptor signaling and CD4/CD8 lineage choice during T cell development in the thymus -- An agent-based model of T helper cell fate decisions in the thymus -- Modelling naive T cell homeostasis -- Mechanistic models of CD4 T cell homeostasis and reconstitution in health and disease -- Section 1MODELING THE DYNAMICS OF CD4+ T CELLS IN HIV- 1 INFECTION -- Modelling the response to Interleukin-7 therapy in HIV-infected patients -- Modeling immunopathology during persistent viral infections -- Delay in differentiation may suggest division of labour in models for CD8+ T cell differentiation -- Inferring differentiation order in adaptive immune responses from population level data -- Experimental and mathematical approaches to quantify recirculation kinetics of lymphocytes -- The public face and private lives of T cell receptor repertoires -- Population dynamics of immune repertoires -- Mathematical Modelling of T cell activation -- Agent-based model of heterogeneous T cell activation in vitro -- CTLA-4 mediated ligand trans-endocytosis: a stochastic model -- Automated gating and dimension reduction of high-dimensional cytometry data -- Index.
    Abstract: The purpose of this book is to present current mathematical and computational models that are used to describe and characterise the immunology of T cells. The reader will be exposed to a variety of tools/methods that go hand-in-hand with the T cell-mediated immunological process that is being modelled. We aim in the proposed book to emphasise the role that mathematical (or computational) modelling has already played in Immunology. Each chapter will provide an example of the contribution of mathematics to T cell immunology under one of the following four headings: i) Generation of hypotheses, ii) Quantification of immunological processes, iii) Definition of observables to measure given an experimental objective, iv) reconciling disparate (or even conflicting) experimental results. .
    Type of Medium: Online Resource
    Pages: X, 298 p. 74 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030572044
    URL: https://doi.org/10.1007/978-3-030-57204-4
    DOI: 10.1007/978-3-030-57204-4
    DDC: 571.96
    Language: English
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  • 26
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    Online Resource
    Lung Inflammation in Health and Disease, Volume I (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Human physiology. ; Medicine Research. ; Biology Research. ; Respiratory organs Diseases. ; Immunology. ; Human Physiology. ; Biomedical Research. ; Pneumology.
    Description / Table of Contents: 1. Potential role of mast cells in regulating corticosteroid insensitivity in severe asthma -- 2. Galectin-3 Promotes ROS, Inflammation and Vascular Fibrosis in Pulmonary Arterial Hypertension -- 3. Anti-Inflammatory Effects of Statins in Lung Vascular Pathology: From Basic Science to Clinical Trials -- 4. Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension -- 5. Pulmonary Inflammation and KRAS Mutation in Lung Cancer -- 6. microRNA Targets for Asthma Therapy -- 7. Roles of genetic predisposition in the sex-bias of pulmonary pathophysiology, as a function of estrogens -- 8. Hypercapnic respiratory failure-driven skeletal muscle dysfunction: It is time for animal mod-els-based mechanistic research -- 9. Role of airway smooth muscle in inflammation related to asthma and COPD -- 10. Systemic Sclerosis and Pulmonary Disease -- 11. Innate Lymphoid Cells in airway inflammation -- 12. Sjogren’s Syndrome and pulmonary disease -- 13. Redox Regulation, Oxidative Stress and Inflammation in Group 3 Pulmonary Hypertension -- 14. Sex-Steroid Signaling in Lung Diseases and Inflammation -- 15. Cytokines, Chemokines and Inflammation in Pulmonary Arterial Hypertension -- 16. Interactive roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases -- 17. Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis -- 18. Crosstalk between Lung and Extrapulmonary Organs in Infection and Inflammation -- 19. Inflammation in Pulmonary Arterial Hypertension -- 20. Lysophospholids in Lung Inflammatory Diseases.
    Abstract: Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung diseases are neither always effective, nor often condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases are not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung diseases, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, fellows, and students with new perspectives and concepts. The editor hopes this book will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.
    Type of Medium: Online Resource
    Pages: XV, 409 p. 54 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030630461
    Series Statement: Advances in Experimental Medicine and Biology, 1303
    URL: https://doi.org/10.1007/978-3-030-63046-1
    DOI: 10.1007/978-3-030-63046-1
    DDC: 571.96
    Language: English
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    Pathogenesis of Systemic Lupus Erythematosus : Insights from Translational Research (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medicine Research. ; Biology Research. ; Cytokines. ; Immunology. ; Biomedical Research. ; Cytokines and Growth Factors.
    Description / Table of Contents: Advances in translational science to identify new therapies for systemic lupus erythematosus -- Hallmark of systemic lupus erythematosus: Role of B Cell Hyperactivity. Fabien B Vincent, William A Figgett and Margaret L Hibbs -- B cell targeted therapies in systemic lupus erythematosus -- Type I Interferons and the perpetuation of a loss of tolerance -- Therapeutic Modulation of the Interferon Pathway in Systemic Lupus Erythematosus -- The concept of co-stimulatory blockade in SLE -- Cytokines: their role in amplifying SLE pathogenesis -- Intracellular targets in SLE -- Regulatory T cells in SLE -- Balancing strategies: GC and GILZ Axis.
    Abstract: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
    Type of Medium: Online Resource
    Pages: XXI, 178 p. 36 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851613
    URL: https://doi.org/10.1007/978-3-030-85161-3
    DOI: 10.1007/978-3-030-85161-3
    DDC: 571.96
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    Online Resource
    The Collectin Protein Family and Its Multiple Biological Activities (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical microbiology. ; Proteins . ; Immunology. ; Medical Microbiology. ; Protein Biochemistry.
    Description / Table of Contents: 1. Discovering the role of mannose-binding lectin (MBL) in innate immunity: the early history -- 2. Mannose-binding lectin in human health and disease -- 3. The activities of MASPs, complement proteases associated with collectins and ficolins -- 4. Structures of the MASPs and comparison with C1r and C1s -- 5. Biological activities of SP-A and SP-D against extracellular and intracellular pathogens -- 6. Surfactant protein D: A Therapeutic Target for Allergic Airway Diseases -- 7. SP-D in immune surveillance against cancer -- 8.Testicular immune privilege – a recently discovered domain of Collectins -- 9. Role of Collectins in Pregnancy -- 10. Bovine Collectins: Role in Health and Disease -- .
    Abstract: The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging activities of Collectins, such as: · Their role in metabolism, and therefore their involvement in lifestyle diseases such as obesity and cardiovascular disease. · Their ability to modulate the adaptive immune response, as well as to recognize and trigger apoptosis of cancer cells, which makes them effective in the annihilation of cancer cells with multiple mutations. · The regulation of their expression by gonadal steroid hormones implicates them with critical roles in both male and female fertility. · Altered levels of Collectins have been associated with various autoimmune diseases. This book brings together current knowledge of the structure, functions and biological activities of Collectins, to describe their integral role in human health.
    Type of Medium: Online Resource
    Pages: XII, 244 p. 50 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030670481
    URL: https://doi.org/10.1007/978-3-030-67048-1
    DOI: 10.1007/978-3-030-67048-1
    DDC: 571.96
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    Alternative Medicine Interventions for COVID-19 (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Alternative medicine. ; Virology. ; Therapeutics. ; Nutrition   . ; Food science. ; Immunology. ; Complementary and Alternative Medicine. ; Virology. ; Therapeutics. ; Nutrition. ; Food Science.
    Description / Table of Contents: 1. Introduction to COVID-19 -- 2. Medicinal plants as COVID-19 remedy -- 3. Traditional Chinese Medicines as possibly remedy Against SARS- CoV-2 -- 4. Plant natural products against COVID-19 -- 5. Foods as first defense against COVID-19 -- 6. Drugs for the treatment of COVID-19 -- 7. COVID-19 pandemic and vaccines -- 8. Recent updates in vaccine development against COVID-19 -- 9. Recent developments in therapeutic approaches against COVID-19.
    Abstract: This research volume examines the available alternative, complementary, pharmaceutical and vaccine methods for treating, mitigating, or preventing COVID-19. Coverage includes traditional Chinese medicine, herbal remedies, nutraceutical/dietary options, and drug/vaccine therapies. All the methods discussed will be critically examined to provide readers with a full, unbiased overview that includes pros/cons of each method. While the nature of COVID-19 is still being studied, and new research and theories are being published daily, this book endeavors to provide readers with a comprehensive summary of current research on alternative and mainstream treatment and prevention methods. .
    Type of Medium: Online Resource
    Pages: XII, 284 p. 120 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679897
    URL: https://doi.org/10.1007/978-3-030-67989-7
    DOI: 10.1007/978-3-030-67989-7
    DDC: 571.96
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  • 30
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    Online Resource
    Advances in Host-Directed Therapies Against Tuberculosis (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Diseases. ; Therapeutics. ; Immunology. ; Diseases. ; Therapeutics.
    Description / Table of Contents: Section 1: Introduction -- Chapter 1: Introduction: An overview of host-directed therapies for tuberculosis -- Section 2: Targeting immunometabolism -- Chapter 2: Sirtuin deacetylases: Linking Mycobacterial infection and host metabolism -- Chapter 3:The mammalian target of rapamycin complex 1 (mTORC1): an ally of M. tuberculosis in host cells -- Chapter 4: HIF-1α as a potential therapeutic target for tuberculosis treatment -- Chapter 5: Nuclear receptors in host-directed therapies against tuberculosis -- Section 3: Enhancing anti-mycobacterial mechanisms -- Chapter 6: Autophagy as a target for host-directed therapy against tuberculosis -- Chapter 7: Metformin: a leading HDT candidate for TB -- Chapter 8: Statins as host-directed therapy for tuberculosis -- Chapter 9: Antimycobacterial attributes of mitochondria: An insight into host defense mechanisms -- Section 4: Targeting immune cells -- Chapter 10: Conventional and unconventional lymphocytes in immunity against Mycobacterium tuberculosis -- Chapter 11: Targeting inhibitory cells such as Tregs and MDSCs in the tuberculous granuloma -- Chapter 12: Targeting suppressor T cells -- Chapter 13: Neutrophil-mediated mechanisms as targets for host-directed therapies against tuberculosis -- Chapter 14: Type I interferon and interleukin-1 driven inflammatory pathways as targets for HDT in tuberculosis -- Chapter 15: Mucosal-associated invariant and Vγ9Vδ2 T cells -- Chapter 16: Airway epithelial cells.-Section 5: Preclinical models for assessing HDTs -- Chapter 17: In vitro models of human granuloma formation to analyze host-directed therapies -- Chapter 18: C3HeB/FeJ as a key mouse strain for testing host-directed therapies against tuberculosis -- Chapter 19: The Rabbit Model for Assessing Host-Directed Therapies for Tuberculosis -- Section 6: Clinical trials of HDTs and special considerations for study endpoints -- Chapter 20:Clinical trials of TB-HDT candidates -- Chapter 21:Outcomes for clinical trials of host-directed therapies for tuberculosis -- Chapter 22: Pharmacological considerations for clinical trials of host-directed therapies for tuberculosis.
    Abstract: This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the reader will derive from learning about the biology of multiple host pathways involved in health and disease, how these pathways are disrupted or dysregulated during tuberculosis, and which druggable targets exist in these pathways. This book provides the reader with a roadmap of current and future directions of HDT against tuberculosis. Since the host pathways/factors involved in protective or maladaptive responses to tuberculosis are not disease-specific, information learned from the context of tuberculosis likely will be relevant to other infectious and non-infectious diseases.
    Type of Medium: Online Resource
    Pages: XIII, 332 p. 20 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030569051
    URL: https://doi.org/10.1007/978-3-030-56905-1
    DOI: 10.1007/978-3-030-56905-1
    DDC: 571.96
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    Close Encounters of the Microbial Kind : Everything You Need to Know About Common Infections (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical sciences. ; Virology. ; Diseases. ; Patient education. ; Immunology. ; Health Sciences. ; Virology. ; Diseases. ; Patient Education.
    Description / Table of Contents: 1. Microbes and infectious diseases -- 2. Acne -- 3. Skin abscesses (boils) -- 4. Dandruff -- 5. Fungal nail infections -- 6. Fungal infections of the skin -- 7. Chickenpox -- 8. Shingles -- 9. Common warts -- 10. The common cold -- 11. Influenza -- 12. Sore throat -- 13. Coronavirus disease-2019 -- 14. Acute sinusitis -- 15. Chronic sinusitis -- 16. Otitis media (middle ear infection) -- 17. Otitis externa (swimmers ear) -- 18. Acute bronchitis (chest cold) -- 19. Conjunctivitis (pink eye) -- 20. Tooth decay (caries) -- 21. Gum disease -- 22. Bad breath -- 23. Oral thrush -- 24. Oral herpes -- 25. Cystitis (lower urinary tract infection) -- 26. Vaginitis -- 27. Chlamydia -- 28. Gonorrhoea -- 29. Genital herpes -- 30. Genital warts -- 31. Syphilis -- 32. Gastroenteritis due to Campylobacter -- 33. Gastroenteritis due to Salmonella -- 34. Gastroenteritis due to Clostridium perfringens -- 35. Gastroenteritis due to Norovirus -- 36. Gastroenteritis due to Rotavirus.
    Abstract: Microbes – can’t live with them, can’t live without them. Increasingly, we’re finding out that our microbiota (the microbes that live on us) are essential for our wellbeing – they provide us with nutrients and vitamins and play a key role in developing our immune system. On the other hand, they are responsible for a great deal of misery, as they are major causes of death and debility around the world. As well as our own microbiota turning against us, there are lots of other microbes out in the wider world that can seriously damage, or even kill, those they infect. The current pandemic of COVID-19 shows the devastating effect that an infectious disease can have – our lives have been turned upside down. If you live in a developed country, you’re not likely to get killer diseases such as ebola and cholera, but you do have a high chance of catching other infections that can have a significant impact on your wellbeing. This book focuses on those infections you’re most likely to go down with, and supplies the answers to the following questions about them: Which infectious diseases are we likely to come across? How common are they? What microbes cause them? What happens to our bodies during an infection? How are the resulting illnesses treated? How can we avoid getting them? This book covers nearly 60 infectious diseases that people living in developed countries are likely to experience at some point during their life. It also has an introductory chapter that describes, in everyday language, the basic principles of microbiology and infectious diseases. Each chapter is lavishly illustrated, has interesting, relevant inserts, and provides a list of web-accessible suggestions for further reading.
    Type of Medium: Online Resource
    Pages: XV, 526 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030569785
    URL: https://doi.org/10.1007/978-3-030-56978-5
    DOI: 10.1007/978-3-030-56978-5
    DDC: 571.96
    Language: English
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    Microbial Pathogenesis : Infection and Immunity (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Pharmacology. ; Internal medicine. ; Immunology. ; Pharmacology. ; Internal Medicine.
    Description / Table of Contents: 1.Human Papillomavirus-associated cancers -- 2. Mechanisms of immune evasion by Ebola virus -- 3. Innate immune mechanisms against HIV-1 -- 4. Current insights into the host immune response to respiratory viral infections -- 5. Immune responses to MERS-CoV in humans and animals -- 6. SARS-CoV-2: Pathogenesis and host-pathogen interaction -- 7. Antibiotic Resistance mechanisms and their transmission in Acinetobacter baumannii -- 8. Pathogenesis and host immune response in leprosy -- 9. Innate immunity and tuberculosis -- 10. Vaccination strategies against Mycobacterium tuberculosis: BCG and beyond -- 11. Candida pathogenicity and interplay with the immune system -- 12. Immune responses in Malaria and vaccine strategies.
    Abstract: This book updates in detail the microbial pathogenesis of various important pathogens, including HIV-1, MERS, SARS-CoV-2, Mycobacterium and Plasmodium. There is also a general discussion of the innate and adaptive immune responses against primary and opportunistic infections. The overall purpose of the book is to aid in the development of anti-viral and anti-microbial targets.
    Type of Medium: Online Resource
    Pages: XIII, 291 p. 35 illus., 33 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030674526
    Series Statement: Advances in Experimental Medicine and Biology, 1313
    URL: https://doi.org/10.1007/978-3-030-67452-6
    DOI: 10.1007/978-3-030-67452-6
    DDC: 571.96
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    Complex Systems and Computational Biology Approaches to Acute Inflammation : A Framework for Model-based Precision Medicine (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Bioinformatics. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: 1. An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine -- 2 Translational Equation-based Modeling -- 3. Agent-based Modeling in Translational Systems Biology -- 4. Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -- 5. Therapeutics as Control: Model-based approaches for control discovery -- 6. Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -- 7. Multi-scale equation-based models: Insights for Inflammation and Physiological Variability -- 8. In silico Trials and Personalized Therapy for Sepsis and Trauma -- 9. Computational Modeling of the Coagulation Response -- 10. Disorder of Localized Inflammation in Wound Healing -- 11. Equation-based Models of Wound Healing and Collective Cell Migration -- 12. Agent-based Models of Wound Healing -- 13. Tissue realistic translational modeling of gut inflammation -- 14. Data-Driven Modeling of Liver Injury, Inflammation, and Fibrosis -- 15. Computational Modeling of Tuberculosis -- 16. The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases -- Index.
    Abstract: This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling. This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.
    Type of Medium: Online Resource
    Pages: IX, 312 p. 51 illus., 37 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030565107
    URL: https://doi.org/10.1007/978-3-030-56510-7
    DOI: 10.1007/978-3-030-56510-7
    DDC: 571.96
    Language: English
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    Online Resource
    Immunology: Overview and Laboratory Manual (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medicine Research. ; Biology Research. ; Immunology. ; Biomedical Research.
    Description / Table of Contents: Part I: Overview of Immunity -- Ch 1: Immunity -- Ch 2: Components of immunity -- Ch 3: Hematopoiesis -- Ch 4: The Immune system: pathogen sensing and detection -- Ch 5: Lymphoid organs -- Ch 6: Innate and Adaptive immunity -- Ch 7: Leukocyte homing, migration and recirculation -- Ch 8: Apoptosis -- Ch 9: Antigens -- Ch 10: B cell development, activation and immunoglobulin structure -- Ch 11: Immunoglobulin and T cell receptor gene rearrangements -- Ch 12: Major histocompatibility complex proteins -- Ch 13: T cell development and T cell receptor structure -- Ch 14: Cytokines -- Ch 15: Lymphocyte signals -- Ch 16: Complement fixation -- Ch 17: Cell mediated immunity -- Ch 18: Hypersensitivities -- Ch 19: Parasite Immunity -- Ch 20: Vaccines -- Ch 21: Transplantation -- Ch 22: Immune regulation and autoimmunity -- Ch 23: Immunodeficiencies -- Ch 24: Cancer -- Ch 25: Practice questions -- Ch 26: Study guide for exam. Part II. Laboratory Manual -- 27. Immunology laboratory policies -- 28. Instructions for notebook entries -- 29. Instructions for writing lab reports -- 30. Lab report topics -- 31. Exercise 1: Using a compound microscope -- 32. Exercise 2: Pipetting and dilution technique, identification of mouse lymphoid organs -- 33. Exercise 3: Blood Cell Preparation, Leukocyte differentiation and ABO Blood Typing -- 34. Exercise 4: Single Suspension of Mouse Spleen cells, Cell Viability Assays, and Identification of specific cells using surface antigens -- 35. Exercise 5: Isolation of mouse peritoneal macrophages: In vitro phagocytosis of bacterial cells -- 36. Exercise 6: Clearance of bacteria from mouse blood by the RES -- 37. Exercise 7: Hemolytic Plaque assay (The Jeme Plaque Assay) -- 38. EXERCISE 8: Rabbit and Mouse Immunizations- Preparation of Polyclonal antibodies and screening assays -- 39. EXERCISE 9: Determination of Antibody Titer: Screening Techniques -- 40. EXERCISE 10: Immunodiffusion and Immunoelectrophoresis -- 41. EXERCISE 11: Protein Affinity Purification of Rabbit IgG -- 42. EXERCISE 12: Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) -- 43. EXERCISE 13: Immunoblotting (Western Blotting) -- 44. Exercise 14: Protein Assay -- 45. Exercise 15: Enzyme-linked Immunosorbent Assay (ELISA) -- 46. EXERCISE 16: Enzyme-Linked Immunospot Assay (ELISPOT) -- 47. EXERCISE 17: Immunofluorescence assay (IFA) -- 48. EXERCISE 18: Flow Cytometry -- 49.EXERCISE 19: Complement Fixation Assays -- 50. Tissue Cell Culture Techniques -- 51. EXERCISE 20: Mitogen Induced Response of Lymphocytes: Detection of Band T cell Lymphocytes Using Immunofluorescence -- 52. Exercise 21: Induction of IL-2 Secretion from Mouse Lymphoma Cells -- 53. EXERCISE 22: Adoptive Transfer of Lymphocytes: Band T cell Cooperation for Antibody Production -- 54. EXERCISE 23: Macrophage Migration Inhibition -- 55. EXERCISE 24: Monoclonal Antibody Preparation -- 56. EXERCISE 25: Immunization of mice with a recombinant protein -- 57. EXERCISE 26: Polarization of T helper cells into TH1 subset -- 58. Exercise 27: Immunoprecipitation -- 59. EXERCISE 28: Induction of apoptosis in T lymphocytes and detection of apoptotic markers -- 60. EXERCISE 29: Cloning and sequencing of cDNAs of mouse variable regions of H and L chains of monoclonal antibodies -- Appendix -- Sample Practice Questions.
    Abstract: A two-in-one text providing teaching lab students with an overview of immunology as well as a lab manual complete with current standard exercises. Section I of this book provides an overview of the immune system and immunity, and includes review questions, problem sets, case studies, inquiry-based questions, and more to provide students with a strong foundation in the field. Section II consists of twenty-two lab exercises focused on key concepts in immunology, such as antibody production, cell separation, cell function, immunoassays, Th1/Th2 cytokine detection, cell and tissue culture methods, and cell and molecular biology techniques. Appendices include safety information, suggested links and readings, and standard discipline processes, protocols, and instructions.
    Type of Medium: Online Resource
    Pages: XX, 471 p. 61 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030646868
    URL: https://doi.org/10.1007/978-3-030-64686-8
    DOI: 10.1007/978-3-030-64686-8
    DDC: 571.96
    Language: English
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    Bone Marrow Niche : Microenvironments Critical for Immune Cell Development (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Stem cells. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Stem Cell Biology. ; Biomedical Research. ; Human Physiology.
    Description / Table of Contents: Preface -- Skeletal stem cells as the developmental origin of cellular niches for hematopoietic stem and progenitor cells -- Cellular niches for hematopoietic stem cells and lympho-hematopoiesis in bone marrow during homeostasis and blood cancers -- Remodeling of the bone marrow stromal microenvironment during pathogenic infections -- The Roles of IL-7 and IL-15 in Niches for Lymphocyte Progenitors and Immune Cells in Lymphoid Organs -- Lymph node stromal cells: diverse meshwork structures weave functionally subdivided niches -- Immune Niche within the Peritoneal Cavity.
    Abstract: This volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.
    Type of Medium: Online Resource
    Pages: VII, 134 p. 19 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030860165
    Series Statement: Current Topics in Microbiology and Immunology, 434
    URL: https://doi.org/10.1007/978-3-030-86016-5
    DOI: 10.1007/978-3-030-86016-5
    DDC: 571.96
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    Three Dimensional Human Organotypic Models for Biomedical Research (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Cancer. ; Regenerative medicine. ; Stem cells. ; Cytology Technique. ; Immunology. ; Cancer Biology. ; Regenerative Medicine and Tissue Engineering. ; Stem Cell Biology. ; Cytological Techniques.
    Description / Table of Contents: Introduction: Rationale of using skin models in research -- Skin anatomy (human and animals for experimental research) -- In vivo skin models -- In vitro human skin models (Skin equivalents vs skin explants) -- Human skin models for studying cutaneous infections -- Skin animal models for pharmacological research -- Human skin models for pharmacological research -- Human skin models for allergological research -- Human skin models for cancer research -- Human skin models for vaccine research.
    Abstract: This edited volume discusses the application of very diverse human organotypic models in major areas of biomedical research. The authors lay a main focus on infectious diseases, cancer, allergies, as well as drug/vaccine discovery and toxicology studies. Representing a valid alternative to laboratory animals, these models are relevant for most areas of translational research. As the contemporary research shows, many human tissues can today be cultivated in vitro and used for several research objectives. This book provides an unprecedented overview of recent developments in an exciting field of research methodology. It is a reference guide for scientists in both academia and industry. Readers can update their knowledge and get hands-on recommendations on how to set up an organotypic model in their lab. Chapters 'Progress on Reconstructed Human Skin Models for Allergy Research and Identifying Contact Sensitizers' and 'Human Organotypic Models for Anti-infective Research' of this book are available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 265 p. 22 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030624521
    Series Statement: Current Topics in Microbiology and Immunology, 430
    URL: https://doi.org/10.1007/978-3-030-62452-1
    DOI: 10.1007/978-3-030-62452-1
    DDC: 571.96
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    Amino Acids in Nutrition and Health : Amino acids in systems function and health (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Medical sciences. ; Cytology. ; Biochemistry. ; Nutrition   . ; Immunology. ; Health Sciences. ; Cell Biology. ; Biochemistry. ; Nutrition.
    Description / Table of Contents: Preface -- Amino acids in intestinal physiology and health -- Amino acid metabolism in the liver: nutritional and physiological significance -- Amino acids in circulatory function and health -- Epithelial dysfunction in lung diseases: effects of amino acids and potential mechanisms -- Amino acid metabolism in the kidneys: nutritional and physiological significance -- Amino acids in health and endocrine function -- Amino Acids in Reproductive Nutrition and Health -- Impacts of amino acids on the intestinal defensive system -- Maternal nutrient restriction and skeletal muscle development: Consequences for postnatal health -- Metabolism of amino acids in the brain and their roles in regulating food intake -- Metabolism and functions of amino acids in the skin -- Metabolism and functions of amino acids in sense organs. .
    Abstract: This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in all the systems of humans and other animals (including livestock, poultry, companion animals, and fish). It enables readers to understand the crucial roles of amino acids and their metabolites in the health and diseases of the circulatory, digestive, endocrine, immune, muscular, nervous, reproductive, respiratory, skeletal, and urinary systems, as well as the sense organs (eyes, ears, nose, skin, and tongue). Readers will learn that amino acids are not only the building blocks of protein, but are also signalling molecules, as well as regulators of gene expression, metabolic processes and developmental changes in the body. This knowledge will guide nutritional practices to improve the growth, development and health of humans and other animals, as well as prevent and treat chronic (e.g., obesity, diabetes, and cardiovascular disorders) and infectious (e.g., bacterial, fungal, parasite, and viral) diseases. Editor of this volume is an internationally recognized expert in nutritional biochemistry. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals as well as undergraduate and graduate students in animal science, biochemistry, biomedical engineering, biology, human medicine, food science, kinesiology, nursing, nutrition, pharmacology, physiology, toxicology, veterinary medicine, and other related disciplines. In addition, all chapters provide general and specific references to amino acids in systems health for researchers and practitioners in biomedicine, animal and plant agriculture, and aquaculture, and for government policy makers.
    Type of Medium: Online Resource
    Pages: VI, 220 p. 36 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030453282
    Series Statement: Advances in Experimental Medicine and Biology, 1265
    URL: https://doi.org/10.1007/978-3-030-45328-2
    DOI: 10.1007/978-3-030-45328-2
    DDC: 571.96
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    Advanced Concepts in Human Immunology: Prospects for Disease Control (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Pharmacology. ; Diseases. ; Cancer. ; Immunology. ; Pharmacology. ; Diseases. ; Cancer Biology.
    Description / Table of Contents: 1. Human Chronic Viruses: Pathogenesis, host response, and treatment -- 2. Defining the Role of Immunoproteomics in Human Immunotherapy -- 3. Microbiome and Cellular Players in Type 1 Diabetes: from Pathogenesis to Protection -- 4. Immune Mechanisms, Pathology, and Management of Allergic Ocular Diseases -- 5. Dendritic Cell-regulated T Cell Immunity and Tolerance against Acute Myeloid Leukemia -- 6. Perspectives on the Role of T cell Negative Immune Checkpoint Receptors in Health and Disease -- 7. Neuroprotective Immunity for Neurodegenerative and Neuroinfectious Diseases -- 8. Polycystic Ovary Syndrome: An overview of a complex, heterogeneous genetic condition.
    Abstract: This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.
    Type of Medium: Online Resource
    Pages: XVIII, 403 p. 16 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030339463
    URL: https://doi.org/10.1007/978-3-030-33946-3
    DOI: 10.1007/978-3-030-33946-3
    DDC: 571.96
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    Outbreak in the Village : A Family Doctor's Lifetime Study of Whooping Cough (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Life sciences. ; Pharmacology. ; Medical sciences. ; Medicine History. ; Public health. ; Immunology. ; Life Sciences. ; Pharmacology. ; Health Sciences. ; History of Medicine. ; Public Health.
    Description / Table of Contents: 1. Introduction -- 2. From Africa to England -- 3. The children's clinic at Keyworth -- 4. Whooping cough vaccine -- 5. 1977-79: The first outbreak of whooping cough -- 6. Does the vaccine work? -- 7. 1981: Whooping cough vaccine is very rarely harmful -- 8. 1981-83: The second outbreak. How many cases are there really? -- 9.1985-87: The third outbreak. The search for subclinical infection -- 10. Does the effectiveness of the vaccine wear off? -- 11. 1988: Trying to raise the uptake of pertussis vaccine -- 12. 1989-91: The fourth outbreak. The natural history of whooping cough -- 13. 1990's: Whooping cough fades away but new diagnostic tests emerge -- 14. 2000: Whoopingcough.net. Overcoming diagnostic paralysis -- 15. The early noughties: The new tests aid the rediscovery of whooping cough -- 16. Late noughties: "Resurgence" of whooping cough in the USA and Australia puts the UK on alert -- 17. 2012: Whooping cough diagnoses peak in the UK but remain unchanged in Keyworth -- 18. What lies ahead? -- 19. Epilogue -- Appendix.
    Abstract: Outbreak in the Village is a fascinating account of the personal and professional journey of Dr. Doug Jenkinson, physician and researcher. Over the course of four decades in practice, Jenkinson traces the reemergence of whooping cough in the developed world, using his practice in the idyllic English countryside as a clinical control group. Keeping meticulous notes and indulging an itch to investigate, he explores one of history's most enigmatic and pervasive diseases. Jenkinson relates the tale of his life's work amid winsome anecdotes, relevant history, and practical advice. Told in an amiable, engaging voice with an expert balance of levity and earnestness, this story will charm casual readers interested in medical history and memoir, as well as doctors and researchers who identify with the experiences and may benefit from the research and techniques employed. Readers will find themselves in the examination room beside Jenkinson as the investigation unfolds, learning about the nature of the illness and the sweeping detrimental effects of an anti-vaccination campaign. An intriguing memoir about a mysterious illness, a public health failure, and one doctor's quest for clarity, Outbreak in the Village is a tale of perseverance and objectivity sure to delight and inform. .
    Type of Medium: Online Resource
    Pages: XXIII, 158 p. 63 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030454852
    Series Statement: Springer Biographies,
    URL: https://doi.org/10.1007/978-3-030-45485-2
    DOI: 10.1007/978-3-030-45485-2
    DDC: 571.96
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    Nrf2 and its Modulation in Inflammation (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Cytology. ; Molecular genetics. ; Stress (Physiology). ; Immunology. ; Cell Biology. ; Molecular Genetics. ; Cellular Stress.
    Description / Table of Contents: Chapter 1. Molecular mechanisms of Nrf2 in inflammation: Interactions between Nrf2 and inflammatory mediators -- Chapter 2. Nrf2 in immune responses during inflammation -- Chapter 3. Nrf2 and Nrf2-interacting network in respiratory inflammation and diseases -- Chapter 4. Nrf2 in the regulation of endothelial cell homeostasis during inflammation -- Chapter 5. The roles of Nrf2 in cardiovascular system and atherosclerosis -- Chapter 6. Nrf2 and inflammation-triggered carcinogenesis -- Chapter 7. Role of Nrf2 in oxidative and inflammatory processes in obesity and metabolic diseases -- Chapter 8. Modulators of Nrf2 Activation during Inflammation.
    Abstract: Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation,respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.
    Type of Medium: Online Resource
    Pages: IX, 205 p. 51 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030445997
    Series Statement: Progress in Inflammation Research, 85
    URL: https://doi.org/10.1007/978-3-030-44599-7
    DOI: 10.1007/978-3-030-44599-7
    DDC: 571.96
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    Inducible Lymphoid Organs (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Diseases. ; Cancer. ; Human physiology. ; Immunology. ; Diseases. ; Cancer Biology. ; Human Physiology.
    Description / Table of Contents: Basics of Inducible Lymphoid Organs -- Role of iBALT in respiratory immunity -- Chronic inflammation in mucosal tissues: Barrier integrity, inducible lymphoid tissues, and immune surveillance -- Role of lymphoid structure in skin immunity -- Memory lymphocyte clusters in genital immunity: Role of tissue-resident memory T cells (TRM) -- Ectopic lymphoid tissue in Rheumatoid Arthritis -- Artificial construction of immune tissues/organoids and their application for immunological intervention.
    Abstract: This book sheds new light on “inducible” lymphoid organs (ILOs): antigen presentation sites that are generated de novo in peripheral tissues under various pathogenic conditions. Accomplished immunologists demonstrate that the physiological role of these ILOs is completely different from that of central lymphoid organs, i.e., the lymph nodes or spleen. In addition to the central organs, the ILOs are considered essential structures for the efficient elicitation of adaptive immune responses in lesions. The respective chapters highlight examples from multiple sites, e.g. the skin, lung, intestinal tract, genital tract, the synovial membrane of the joints and artificial lymph nodes. Accordingly, readers will learn that ILO structure and function can vary substantially, depending on the context. Presenting the results of the latest immunological research, the book offers a fascinating and insightful read for both scientists and clinicians in the areas of infectious and immune-associated diseases.
    Type of Medium: Online Resource
    Pages: VII, 160 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030517472
    Series Statement: Current Topics in Microbiology and Immunology, 426
    URL: https://doi.org/10.1007/978-3-030-51747-2
    DOI: 10.1007/978-3-030-51747-2
    DDC: 571.96
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    Liver Immunology : Principles and Practice (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Immunology.
    Description / Table of Contents: 1. Core Concepts in Immunology: The Definition of Autoimmunity and Its Unique Application to the Seat of Tolerance, the Liver -- 2. The Liver as a Lymphoid Organ -- 3. The Uniqueness of Innate Immunity -- 4. Adaptive Immunity and the Clinical Definition of Autoantibodies.-5. Genetics of Autoimmune Liver Diseases -- 6. The Epigenetic Basis of Loss of Tolerance -- 7. Bile Acids and Bilirubin in Liver Immunology -- 8. The Microbiota-Gut-Liver Axis – Implications for the Pathophysiology of Liver Disease -- 9. Diagnostic Liver Immunology -- 10. The Pathologist’s Approach to Reviewing Liver Histology -- 11. Geoepidemiology of Autoimmune Liver Diseases -- 12. Immune Responses to Bacterial Infections -- 13. Immunity of Parasitic Infections of the Liver -- 14. The Treatment of Bacterial and Parasitic Diseases of the Liver -- 15. Hepatitis A and Other Viral Infections -- 16. Hepatitis B Virus -- 17. Hepatitis C -- 18. Hepatitis D -- 19. Hepatitis E -- 20. Alcohol-Associated Liver Disease -- 21. Non-alcoholic Fatty Liver Disease: A Chapter in Liver Immunology -- 22. Primary Biliary Cholangitis -- 23. PSC – AIH Overlap -- 24. Primary Biliary Cholangitis: Autoimmune Hepatitis Overlap Syndrome -- 25. Primary Sclerosing Cholangitis -- 26. Autoimmune Hepatitis -- 27. IgG4-related Disease: Current Concept, Diagnosis, and Pathogenesis -- 28. Pediatric Liver Disease -- 29. Mechanisms of Acute Liver Failure -- 30. Immune-Mediated Drug-Induced Liver Injury -- 31. Hepatobiliary Cancers and Immunology -- 32. Acute-on-Chronic Liver Failure -- 33. The Pathogenesis of Liver Diseases in Pregnancy -- 34. Graft-Versus-Host Disease -- 35. Immunopathogenesis of Liver Cirrhosis -- 36. Immune-Mediated Liver Disease in the Transplanted Liver.
    Abstract: The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver’s role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation. The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs. A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students. .
    Type of Medium: Online Resource
    Pages: XV, 633 p. 145 illus., 135 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030517090
    URL: https://doi.org/10.1007/978-3-030-51709-0
    DOI: 10.1007/978-3-030-51709-0
    DDC: 571.96
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    The M2 Macrophage (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Cytology. ; Lipids. ; Diseases. ; Human physiology. ; Immunology. ; Cell Biology. ; Lipidology. ; Diseases. ; Human Physiology.
    Description / Table of Contents: Chapter 1. Introduction. What is an M2 macrophage? Historical overview of the macrophage polarization model. The Th1/Th2 and M1/M2 paradigms, the arginine fork -- Chapter 2. Evolutionary origin of the M2 macrophage activation: invertebrates -- Chapter 3. Evolution of M2 macrophage functions in chordates -- Chapter 4. Signal mechanisms of M2 macrophage activation -- Chapter 5. Mechanisms which control the size of M2 macrophage-dominated tissue macrophage niches -- Chapter 6.Immune functions of the M2 macrophages: host defense, self-tolerance and autoimmunity -- Chapter 7. M2 macrophages in the integument and in the musculoskeletal system -- Chapter 8. M2 macrophages in the circulatory-, respiratory and excretory organs -- Chapter 9. M2 macrophages in the metabolic organs and in the neuroendocrine system -- Chapter 10. Practical approaches in M2 macrophage biology: analysis, pharmacology and didactical interpretation of M2 macrophage functions.
    Abstract: Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.
    Type of Medium: Online Resource
    Pages: XIII, 224 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504809
    Series Statement: Progress in Inflammation Research, 86
    URL: https://doi.org/10.1007/978-3-030-50480-9
    DOI: 10.1007/978-3-030-50480-9
    DDC: 571.96
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    C-Type Lectins in Immune Homeostasis (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Diseases. ; Proteins. ; Human physiology. ; Cancer. ; Immunology. ; Diseases. ; Proteins. ; Human Physiology. ; Cancer Biology.
    Description / Table of Contents: C-type lectin receptors in phagocytosis -- C-type lectins in immunity to lung pathogens -- Signalling C-type lectins in antifungal immunity -- Dendritic cell immunoactivating receptor: an activating receptor for mycobacteria -- myeloid C-type lectin receptors sensing tissue damage -- 3D structure and ligand recognition of C-type lectins -- Mechanisms and Functions of CARD9 Signaling in the Innate Immune System.
    Abstract: This book focuses on C-type lectin receptors, a newly emerging family of pattern-recognition receptors (PRRs) and a crucial part of the human innate immune system. Above all, the authors highlight these receptors’ role in the recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) – one of the first steps in responding to foreign and potentially dangerous structures in the human body. The respective chapters chiefly examine various C-type lectin receptors, their corresponding ligands, and signalling. In addition to offering immunologists and clinicians important insights from the latest research, they may also provide novel points of departure for future drug development.
    Type of Medium: Online Resource
    Pages: V, 203 p. 60 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030622374
    Series Statement: Current Topics in Microbiology and Immunology, 429
    URL: https://doi.org/10.1007/978-3-030-62237-4
    DOI: 10.1007/978-3-030-62237-4
    DDC: 571.96
    Language: English
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  • 45
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    Online Resource
    Molecular and Cellular Biology of Phagocytosis (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medicine Research. ; Biology Research. ; Medical microbiology. ; Cytology. ; Biochemistry. ; Immunology. ; Biomedical Research. ; Medical Microbiology. ; Cell Biology. ; Biochemistry.
    Description / Table of Contents: An introduction to phagocytosis -- A Brief History of Phagocytosis -- The role of membrane surface charge in phagocytosis -- Receptor models of phagocytosis: the effect of target shape -- Decision Making in Phagocytosis -- Membrane tension and the role of ezrin during phagocytosis -- Molecular mechanisms of calcium signaling during phagocytosis -- Calpain activation by Ca2+ and its role in phagocytosis -- The NADPH oxidase and the phagosome -- Conclusions and the future of phagocytosis.-.
    Abstract: Phagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably “primitive”) cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the “natural” immunity brought about by immune phagocytes. The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.
    Type of Medium: Online Resource
    Pages: X, 189 p. 66 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030404062
    Series Statement: Advances in Experimental Medicine and Biology, 1246
    URL: https://doi.org/10.1007/978-3-030-40406-2
    DOI: 10.1007/978-3-030-40406-2
    DDC: 571.96
    Language: English
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  • 46
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    Online Resource
    Perinatal Inflammation and Adult Psychopathology : From Preclinical Models to Humans (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Psychiatry. ; Gynecology . ; Diseases. ; Neurosciences. ; Psychobiology. ; Human behavior. ; Immunology. ; Psychiatry. ; Gynecology. ; Diseases. ; Neuroscience. ; Behavioral Neuroscience.
    Description / Table of Contents: Chapter 1. Perinatal psychiatry: ready for prime time?- Chapter 2. Pregnancy, stress response and neuroinflammation: effects on offspring and risk for psychiatric disorders -- Chapter 3. Epigenetic modifications of early life stress and adult life psychopathology -- Chapter 4. Perinatal HPA programming and adult psychopatholgoy -- Chapter 5. Intergeneration transmission of depression: focus on inflammation -- Chapter 6. Neonatal bacterial meningitis: mechanisms and implications for adult life psychopathology -- Chapter 7. Toxoplasmosis as risk factor for severe psychiatric disorders: clinical and pre-clinical evidence -- Chapter 8. A critical appraisal on the epidemiological evidence linking perinatal inflammation and risk of psychosis -- Chapter 9. Maternal Immune Activation as a Risk Factor for Schizophrenia: Evidence from Preclinical and Clinical Studies -- Chapter 10. Influences of sex and age in MIA-induced behavioral and neurobiological alterations -- Chapter 11. MIA and autism -- Chapter 12. Zika virus infection and neuropsychiatric complications -- Chapter 13. Placenta immunology: impact on fetus development -- Chapter 14. Placenta and cord blood as source of immune markers of offspring development and psychopathology -- Chapter 15. Cytokine model of cognitive function.
    Abstract: Perinatal psychiatry is an emerging field that investigates the role of perinatal events – for example pregnancy complications and infections – in the development of neuropsychiatric conditions, such as schizophrenia and mood disorders. Among the implicated pathological mechanisms, perinatal-induced inflammation seems to play a major role and is being considered as a potential target for therapeutic intervention. Bringing together various approaches in the field (preclinical and clinical, epidemiological, immunological and genetic methods), the book discusses the available evidence, the putative mechanisms and the challenges ahead.
    Type of Medium: Online Resource
    Pages: XI, 268 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030393359
    Series Statement: Progress in Inflammation Research, 84
    URL: https://doi.org/10.1007/978-3-030-39335-9
    DOI: 10.1007/978-3-030-39335-9
    DDC: 571.96
    Language: English
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