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  • Books  (10)
  • Computational and Systems Biology.  (5)
  • Regenerative Medicine and Tissue Engineering.
  • Cham :Springer International Publishing :  (10)
  • 660.6  (10)
  • 910.285
  • 1
    Online Resource
    Online Resource
    Essential Current Concepts in Stem Cell Biology (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Stem cells. ; Hematology. ; Regenerative medicine. ; Biotechnology. ; Stem Cell Biology. ; Hematology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Hematopoietic Stem Cells -- Mesenchymal Stem Cells -- Cord Blood Stem Cells -- Neural Stem Cells and Their Niche -- Skeletal Muscle Stem Cells -- Heart Muscle Tissue Engineering -- Induced Pluripotent Stem Cells -- Epigenetics of Somatic Cell Reprogramming -- Human Pluripotent Stem Cells and Neural Regeneration -- Dopaminergic Neuron-Related Stem Cells -- Liver Disease Modelling -- Organoids in Developmental Biology Research and Application -- Extracellular Vesicles -- Ethics in Stem Cell Applications.
    Abstract: This textbook describes the biology of different stem cell types and outlines the current level of knowledge in the field. It clearly explains the basics of hematopoietic, mesenchymal cord blood, neural and muscle stem cells and also covers induced pluripotent stem cells and their applications. Further, it includes chapters on organoids, stem-cell based disease modelling, extracellular vesicles and one chapter on ethical aspects of human stem cell research, which promotes critical thinking and responsible handling of the material. Based on lectures of the international master program Molecular and Developmental Stem Cell Biology taught at Ruhr-University Bochum and participation of collaborating professors from Tongji University Shanghai, the book is a valuable source for students, postdocs and researchers, who would like to have introductory chapters on stem cell biology. It also offers essential insights for physicians and dentists wishing to expand their knowledge. This textbook is a valuable complement to Concepts and Applications of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.
    Type of Medium: Online Resource
    Pages: XIV, 242 p. 37 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030339234
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-33923-4
    DOI: 10.1007/978-3-030-33923-4
    DDC: 660.6
    Language: English
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  • 2
    Online Resource
    Online Resource
    Deep Learning in Medical Image Analysis : Challenges and Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Biomedical engineering. ; Radiology. ; Bioinformatics. ; Biotechnology. ; Biomedical Engineering and Bioengineering. ; Radiology. ; Computational and Systems Biology.
    Description / Table of Contents: Deep Learning in Medical Image Analysis -- Medical Image Synthesis via Deep Learning -- Deep Learning for Pulmonary Image Analysis: Classification, Detection, and Segmentation -- Deep Learning Computer Aided Diagnosis for Breast Lesion in Digital Mammogram -- Decision support system for lung cancer using PET/CT and microscopic images -- Lesion Image Synthesis using DCGANs for Metastatic Liver Cancer Detection -- Retinopathy analysis based on deep convolution neural network -- Diagnosis of Glaucoma on retinal fundus images using deep learning: detection of nerve fiber layer defect and optic disc analysis -- Automatic segmentation of multiple organs on 3D CT images by using deep learning approaches -- Techniques and Applications in Skin OCT Analysis -- Deep Learning Technique for Musculoskeletal Analysis -- Index.
    Abstract: This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.
    Type of Medium: Online Resource
    Pages: VIII, 181 p. 131 illus., 114 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030331283
    Series Statement: Advances in Experimental Medicine and Biology, 1213
    URL: https://doi.org/10.1007/978-3-030-33128-3
    DOI: 10.1007/978-3-030-33128-3
    DDC: 660.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Recent Advances in Biological Network Analysis : Comparative Network Analysis and Network Module Detection (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Bioinformatics. ; Medical genetics. ; Biotechnology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1: Global Alignment of PPI Networks -- Chapter 2: Integrated Network-Based Computational Analysis for Drug Development -- Chapter 3: Effective Random Walk Models for Comparative Network Analysis -- Chapter 4: Computational Methods for Protein-Protein Interaction Network Alignment -- Chapter 5: Network Propagation for the Analysis of Multi_Omics Data -- Chapter 6: Motifs in Biological Networks -- Chapter 7: Bio Fabric Visualization of Network Alignments -- Chapter 8: Module Identification of Biological Networks via Graph Partition -- Chapter 9: Network Module Detection to Decipher the Heterogeneity of Cancer Mutations.
    Abstract: This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights. .
    Type of Medium: Online Resource
    Pages: XII, 217 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571733
    URL: https://doi.org/10.1007/978-3-030-57173-3
    DOI: 10.1007/978-3-030-57173-3
    DDC: 660.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Bioimage Data Analysis Workflows (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Cytology. ; Bioinformatics. ; Biology Technique. ; Biotechnology. ; Cell Biology. ; Computational and Systems Biology. ; Biological Techniques.
    Description / Table of Contents: Workflows and Components of Bioimage Analysis -- Measurements of Intensity Dynamics at the Periphery of the Nucleus -- 3D Quantitative Colocalisation Analysis -- The NEMO Dots Assembly: Single-Particle Tracking and Analysis -- Introduction to MATLAB: Image Analysis & Brownian Motion -- Resolving the process of Clathrin Mediated Endocytosis Using Correlative Light & Electron Microscopy (CLEM).
    Abstract: This Open Access textbook provides students and researchers in the life sciences with essential practical information on how to quantitatively analyze data images. It refrains from focusing on theory, and instead uses practical examples and step-by step protocols to familiarize readers with the most commonly used image processing and analysis platforms such as ImageJ, MatLab and Python. Besides gaining knowhow on algorithm usage, readers will learn how to create an analysis pipeline by scripting language; these skills are important in order to document reproducible image analysis workflows. The textbook is chiefly intended for advanced undergraduates in the life sciences and biomedicine without a theoretical background in data analysis, as well as for postdocs, staff scientists and faculty members who need to perform regular quantitative analyses of microscopy images.
    Type of Medium: Online Resource
    Pages: X, 170 p. 69 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030223861
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-22386-1
    DOI: 10.1007/978-3-030-22386-1
    DDC: 660.6
    Language: English
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  • 5
    Online Resource
    Online Resource
    Biomedical Visualisation : Volume 6 (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Bioinformatics. ; Biotechnology. ; Computational and Systems Biology.
    Description / Table of Contents: Web-based 3D visualisation of biological and medical data -- Ultrasound-Guided Regional Anaesthesia: Visualising Nerve and Needle -- Scanning conditions in functional connectivity magnetic resonance imaging: how to standardise resting-state for optimal data acquisition and visualisation? -- Interactive VR Stroke Rehabilitation System Design -- Systematic review of Augmented and Virtual Reality in anatomical education -- Interdimensional travel: Visualisation of 3D-2D transitions in anatomy learning -- Anatomy Visualizations Using Stereopsis: Assessment and Implication of Stereoscopic Virtual Models in Anatomical Education -- Storyboarding in Medical Animation -- The hidden curriculum of imaging and utilisation of unregulated social media resources within clinical education -- Online distance learning in biomedical sciences: Community, belonging and presence. .
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. The first eight chapters examine a variety of tools, techniques, methodologies and technologies which can be utilised to visualise and understand biological and medical data. This includes web-based 3D visualisation, ultrasound, virtual and augmented reality as well as functional connectivity magnetic resonance imaging, storyboarding and a variety of stereoscopic and 2D-3D transitions in learning. The final two chapters examine the pedagogy behind digital techniques and tools from social media to online distance learning techniques.
    Type of Medium: Online Resource
    Pages: XV, 181 p. 69 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030376390
    Series Statement: Advances in Experimental Medicine and Biology, 1235
    URL: https://doi.org/10.1007/978-3-030-37639-0
    DOI: 10.1007/978-3-030-37639-0
    DDC: 660.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Regenerative Medicine and Stem Cell Biology (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Regenerative medicine. ; Reproductive health. ; Stem cells. ; Cancer. ; Biomedical engineering. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Reproductive Medicine. ; Stem Cell Biology. ; Cancer Biology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Basic Concepts of Stem Cells: The Facts and Hype in Stem Cells Research and Development -- Chapter 2. Embryonic and Pluripotent Stem Cells -- Chapter 3. Adult Stem Cells: Hematopoietic Stem Cells, and Control Of Hematopoiesis -- Chapter 4. Adult Stem Cells: Adult Stem Cells: Mesenchymal Stromal Cells, Endothelial Progenitor Cells and Pericytes -- Chapter 5. Cancer Stem Cells and the Development of Cancer -- Chapter 6. Stem Cell Applications In Metabolic Disorders: Diabetes Mellitus -- Chapter 7. Epigenetics in Stem Cell Biology -- Chapter 8. Practicum: Isolation of Bone Marrow and Adipose Tissue Mesenchyme Stromal Cells -- Chapter 9. Induced Pluripotent Stem Cells: Biology, History and in-vitro Generation -- Chapter 10. Tissue Engineering Modalities and Nanotechnology -- Chapter 11. Practicum: Scaffold engineering using the amniotic membrane -- Chapter 12. The Scientific Method, Ethical Consideration and Implications in Stem Cell Research.
    Abstract: This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.
    Type of Medium: Online Resource
    Pages: X, 374 p. 45 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030553593
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-55359-3
    DOI: 10.1007/978-3-030-55359-3
    DDC: 660.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Tissue Engineering : Principles, Protocols, and Practical Exercises (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Regenerative medicine. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Reference search, image & data analysis -- Organ structure & vascularization -- Extracellular matrix & adhesion molecules -- Isolating cells from tissue -- Functional assays & toxicity screening -- Culturing cells in 2D & 3D -- Imaging, staining & markers -- Stems cells & basics of immunology -- Natural & artificial Scaffolds -- Casting & 3D bioprinting -- Bioreactors -- Reporting results -- Index. .
    Abstract: Tissue engineering and regenerative medicine is a new, interdisciplinary branch of science that combines knowledge from numerous scientific fields including biology, biochemistry, physics, chemistry, applied engineering, and medicine. It aims to restore damaged parts of the human body by rebuilding them in vitro using individual building blocks of biological tissues such as cells and the extracellular matrix that surrounds them. The authors hope to spark students’ interest in this exciting new field of science as well as give them a basic knowledge of its terminology. This book is based on a hands-on practical course in tissue engineering conducted by the Fulbright US Scholar recipient, Dr. Narine Sarvazyan (George Washington University, Washington USA). It provides an overview of the core topics of the tissue engineering field, including stem cell differentiation, the role of extracellular matrix and attachment proteins, scaffolds, and culturing of engineered tissues. Each chapter is accompanied by hands-on demonstrations and self-check questions. The text is easily readable for students of all backgrounds and the described protocols can be conducted using common lab equipment. This textbook is also useful for developing undergraduate and graduate courses that teach basic methods and approaches in this promising and rapidly developing field. .
    Type of Medium: Online Resource
    Pages: XXIV, 154 p. 80 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030396985
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-39698-5
    DOI: 10.1007/978-3-030-39698-5
    DDC: 660.6
    Language: English
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  • 8
    Online Resource
    Online Resource
    Biomedical Visualisation : Volume 7 (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Bioinformatics. ; Biotechnology. ; Computational and Systems Biology.
    Description / Table of Contents: Virtual Anatomy Museum – Facilitating Public Engagement Through An Interactive Application -- E-Learning And Embryology; Designing An Application To Improve 3D Comprehension Of Embryological Structures -- Animated Guide to Represent A Novel Means of Gut-brain Axis Communication -- Engaging with Children using Augmented Reality on Clothing to Prevent them from Smoking -- Enabling More Accessible MS Rehabilitation Training Using Virtual Reality -- The Use of Augmented Reality to Raise Awareness of the Differences between Osteoarthritis and Rheumatoid Arthritis -- Understanding the Brain and Exploring the Effects of Clinical Fatigue: From A Patient’s Perspective -- A Methodology for Visualising Growth and Development of the Human Temporal Bone -- Collect the Bones, Avoid the Cones: A Game-Based App for Public Engagement -- A Serious Game on Skull Anatomy for Dental Undergraduates. .
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. All chapters in this volume feature collaborative and innovative postgraduate research projects from graduate students of the MSc Medical Visualisation and Human Anatomy. This pioneering, world-leading postgraduate taught degree program is a joint partnership degree between the School of Life Sciences within the College of Medical, Veterinary and Life Sciences in the University of Glasgow, and the School of Simulation and Visualisation, The Glasgow School of Art. These chapters truly showcase the amazing and diverse technological applications that have been carried out as part of their research projects.
    Type of Medium: Online Resource
    Pages: XVI, 237 p. 268 illus., 238 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030439613
    Series Statement: Advances in Experimental Medicine and Biology, 1262
    URL: https://doi.org/10.1007/978-3-030-43961-3
    DOI: 10.1007/978-3-030-43961-3
    DDC: 660.6
    Language: English
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  • 9
    Online Resource
    Online Resource
    Biomedical Product Development: Bench to Bedside (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Regenerative medicine. ; Medical sciences. ; Biomedical engineering. ; Pharmaceutical chemistry. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Health Sciences. ; Biomedical Engineering and Bioengineering. ; Pharmaceutics.
    Description / Table of Contents: 1. An Introduction to Biomedical Product Development -- 2. Basic Essentials and Applications of Quality Management System (QMS) in Biomedical Sciences -- 3. Principles of Good Laboratory Practice (GLP) -- 4. Design of Experimental Studies in Biomedical Sciences -- 5. Preclinical Studies for Development of Biomedical Products -- 6. Principles of Good Manufacturing Practice (GMP) -- 7.The importance of Cleanroom facility in manufacturing of biomedical products -- 8. Safety concerns and requirement of cell based products for clinical application -- 9. Standards and regulatory frameworks (for cell and tissue based products) -- 10. Principles of Good clinical Practice (GCP) -- 11. Design, performance and monitoring of clinical trials -- 12. Good Clinical Practice: Guidelines and Requirement -- 13. Ethical Considerations of Biomedical Products Development.
    Abstract: This textbook covers all the steps in manufacturing a biomedical product from bench to bedside. It specifically focuses on quality assurance and management and explains the different good practice principles in the various phases of product development as well as how to fulfill them: Good laboratory practice, good manufacturing practice and good clinical practice. It provides readers with the know-how to design biomedical experiments to ensure quality and integrity, to plan and conduct standard preclinical studies and to assure the quality of the final manufactured biomedical products. Importantly, it also addresses ethical concerns and considerations. The book discusses the guidelines and ethical considerations for preclinical and clinical studies, to allow readers to identify safety concerns regarding biomedical products and to improve pre-clinical studies for the development of better products. This textbook is a valuable guide for biomedical students (B.Sc., M.S., and Ph.D. students) in the field of molecular medicine, medical biotechnology, stem cell research and related areas, as well as for professionals such as quality control staff, tissue bankers, policy-makers and health professionals.
    Type of Medium: Online Resource
    Pages: XIV, 157 p. 16 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356262
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-35626-2
    DOI: 10.1007/978-3-030-35626-2
    DDC: 660.6
    Language: English
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  • 10
    Online Resource
    Online Resource
    Basic Concepts on 3D Cell Culture (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Cytology Technique. ; Biomedical engineering. ; Regenerative medicine. ; Biotechnology. ; Cytological Techniques. ; Biomedical Engineering and Bioengineering. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Chapter 1. Introduction to 3D cell culture -- Chapter 2. Lab equipment for 3D cell culture -- Chapter 3. A view from the cellular perspective -- Chapter 4. Biological, natural and synthetic 3D matrices -- Chapter 5. Hydrogels for 3D cell culture -- Chapter 6. Vascularization in 3D cell culture -- Chapter 7. Application of scaffold-free 3D models -- Chapter 8. 10. Microfluidic Systems and Organ (Human) on a Chip -- Chapter 9. 3D-Bioprinting -- Chapter 10. Non-destructive and label-free monitoring of 3D cell constructs.
    Abstract: This textbook shall introduce the students to 3D cell culture approaches and applications. An overview on existing techniques and equipment is provided and insight into various aspects and challenges that researchers need to consider and face during culture of 3D cells is given. The reader will learn the importance of physiological cell, tissue and organ models and gains important knowledge on 3 D analytics. This textbook deepens selected aspects of the textbook “Cell Culture Technology”, which also is published in this series, while offering extended insight into 3D cell culture. The concept of the textbook encompasses various lectures ranging from basics in cell cultivation, tissue engineering, biomaterials and biocompatibility, in vitro test systems and regenerative medicine. The textbook addresses Master- and PhD students interested and/or working in the field of modern cell culture applications and will support the understanding of the essential strategies in 3D cell culture and waken awareness for the potentials and challenges of this application.
    Type of Medium: Online Resource
    Pages: XV, 252 p. 88 illus., 83 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030667498
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-66749-8
    DOI: 10.1007/978-3-030-66749-8
    DDC: 660.6
    Language: English
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