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Biochemistry of Drug Resistance (2021)

Ahmed, Sarfraz. [editor.] ; Chandra Ojha, Suvash. [editor.] ; Najam-ul-Haq, Muhammad. [editor.] ; [et al.]

Cham :Springer International Publishing :

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Keywords: Medical microbiology. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Biotechnology. ; Medical Microbiology. ; Biomedical Research. ; Pharmacology. ; Biomedical Research. ; Biotechnology.

Description / Table of Contents: 1.Introduction to Drugs, Drug Targets and Drug Resistance -- 2.Drugs Resistance in Bacterial Diseases -- 3.Drugs Resistance Against Viral Diseases -- 4.Drug Resistance in Protozoal Infections -- 5.Antifungal Drugs: Mechanism of Action and Resistance -- 6.Drug Resistance in Ear, Nose, and Throat Infections -- 7.Drug Resistance in Skin Diseases -- 8.Drugs Resistance in Lungs Diseases -- 9.Neurological Disorders: Biochemistry of Drug Resistance and Future Challenges -- 10.Drug Resistance in Kidney Diseases -- 11.Drugs resistance in Heart Diseases -- 12.Drugs Resistance in Liver Disease -- 13.Drug Resistance in Cancer -- 14.Drugs Resistance and Treatment Failure in HIV and / or AIDS -- 15.Drug Resistance in Reproductive Diseases -- 16.Drug Resistance in Diabetes -- 17.Drug Resistance in Rheumatological Diseases -- 18.Pherotypes in Streptococcus pneumoniae and Role of CSP-1 and CSP-2 in Antibiotic Susceptibility and Resistance; Towards Development of Live Attenuated Vaccine Candidates in Inducing Netosis Based Acquired Immune Response -- 19.Hypoxia, Obesity and Drug Resistance; Towards Sustainable Development Goals and Globalization -- 20.Genetic and Molecular Mechanisms of Multidrug-resistance in Uropathogens and Novel Therapeutic Combat -- 21.Drugs Resistance Management.

Abstract: This book provides a comprehensive discussion on the current information and evidence on the latest developments in the field of drugs resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. This leads to negative outcomes at great risk of public health; therefore, increasing efforts are dedicated to the development of a new generation of medications that will help deal with this phenomenon. Decades of technological innovations in drug design have demonstrated the potential of resistance. Enormous information on various aspects of antibiotics resistance is available. However, literature on drug resistance specifically related to infectious and non-infectious diseases is rarely presented, particularly those focusing on the mechanisms, biochemistry, kinetics, dynamics, and management of drug resistance. Therefore, there is an immense need for a systematic compilation on the available information about this issue. All the chapters are logically selected and arranged to provide state-of-the-art information about all aspects of drugs resistance. After an introductory chapter, four chapters are dedicated to infectious microbial diseases, whereas two other chapters are complimenting this theme and focusing on drugs resistance in ear, nose and throat, and skin diseases. The recent advances in the understanding of drugs resistance in lung, neurological, kidney, heart, and liver diseases are also covered. Biochemistry of drugs resistance in cancer, HIV, ocular, reproductive, and diabetes diseases is also discussed. Finally, a chapter dedicated to the “management of drug resistance” has been included. .

Type of Medium: Online Resource

Pages: XI, 558 p. 97 illus., 72 illus. in color. , online resource.

Edition: 1st ed. 2021.

ISBN: 9783030763206

URL: https://doi.org/10.1007/978-3-030-76320-6

DOI: 10.1007/978-3-030-76320-6

DDC: 616.9041

Language: English

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Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology : Overview of the First Eukaryome Congress at Institut Pasteur. Paris, October 16–18, 2019. (2020)

Guillen, Nancy. [editor.]

Cham :Springer International Publishing :

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Keywords: Medical microbiology. ; Parasitology. ; Microbiology. ; Medicine Research. ; Biology Research. ; Medical Microbiology. ; Parasitology. ; Microbiology. ; Biomedical Research.

Description / Table of Contents: Eukaryome: Emerging field with profound translational potential -- Resolving amoebozoan encystation from Dictyostelium evo-devo and amoebozoan comparative genomics -- Integrative omics analysis of the effect of bacteria on the resistance of Entamoeba histolytica to oxidative stress -- Histomonas meleagridis molecular traits –from past to future -- Exploring the biology and evolution of Blastocystis and its role in the microbiome -- Advances in the study of Blastocystis spp. in Mexico: prevalence, genetic diversity, clinical association and their possible role in the human intestine -- Cryptosporidium infection in Bangladesh children -- The current molecular epidemiological scenario of Cryptosporidium, Giardia and Blastocystis in Spain. Implication for public health -- The protozoome of the periodontal sulcus: from health to disease -- Tritrichomonas spp. and Their Impact on Gut Immune Homeostasis -- Contribution of host immunity to the development of Entamoeba histolytica-induced liver abscess -- Oxidative Stress And Heat Stress In Experimental Amoebic Liver Abscess -- Role of Extracellular Traps promoted by intestinal parasites. Relationship with virulence -- Parasite secretory molecules in host-parasite interaction -- The Role of Host PKCα during Intracellular Cryptosporidium Infection -- Immune response triggered by Entamoeba histolytica in a 3D-intestinal model -- Receptors for phagocytosis and trogocytosis in Entamoeba histolytica -- PtdIns(3,4,5)P3 binding protein screening reveals unique molecules involved in endocytic processes -- Molecular insights into E. histolytica mediated host tissue invasion -- Vesicular trafficking in Entamoeba histolytica is essential for its virulence -- MOLECULAR CHARACTERIZATION OF Entamoeba histolytica tRNA GENES -- Gene silencing and overexpression to study pathogenicity factors of Entamoeba histolytica -- Polyadenylation machineries in intestinal parasites: latest advances in the protozoan parasite Entamoeba histolytica -- Probiotics as anti-Giardia defenders: Overview on putative control mechanisms -- A protocol to quantify cellular morphodynamics: from cell labelling to automatic image analysis.-.

Abstract: The intestine is home to diverse bacterial communities forming the microbiome that influences host nutrition, immune functions and health. DNA-based methods have been instrumental to gain insight into the microbial eukaryotic diversity of the human gut. For instance, the microbiome share the intestinal ecosystem with a population of uni- and multi-cellular eukaryotic organisms. These eukaryotic organisms are very common and often very abundant in individuals with intestinal healthy conditions as well as those with intestinal diseases. The impact of the relationship between bacterial and eukaryotic organisms within the intestinal ecosystem on homeostasis and intestinal diseases is limited and can be considered an important emerging field of research. In addition, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. All these organisms and their interplay with bacteria and the human immune system are a challenge to assess the impact (present and future) of intestinal infectious diseases on public health. This book presents an overview of the science presented and discussed in the First Eukaryome Congress, held from October 16th to 18th, 2019 at Pasteur Institute in Paris, France. This contributed volume is of special interest for PhD students, postdoctoral fellows, researchers and clinicians interested in the effect of the eukaryotic microbiome on human health.

Type of Medium: Online Resource

Pages: XVII, 367 p. 60 illus., 49 illus. in color. , online resource.

Edition: 1st ed. 2020.

ISBN: 9783030448264

URL: https://doi.org/10.1007/978-3-030-44826-4

DOI: 10.1007/978-3-030-44826-4