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  • English  (85)
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  • 1
    Online Resource
    Online Resource
    Reactive Oxygen Species : Network Pharmacology and Therapeutic Applications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    URL: https://doi.org/10.1007/978-3-030-68510-2
    DOI: 10.1007/978-3-030-68510-2
    DDC: 615
    Language: English
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  • 2
    Online Resource
    Online Resource
    Organotypic Models in Drug Development (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    URL: https://doi.org/10.1007/978-3-030-70063-8
    DOI: 10.1007/978-3-030-70063-8
    DDC: 615
    Language: English
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  • 3
    Online Resource
    Online Resource
    Pharmacology of Potassium Channels (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Neurosciences. ; Pharmacology. ; Human Physiology. ; Neuroscience.
    Description / Table of Contents: Comparison of K+ Channel families -- High-resolution structures of K+ channels -- Pharmacological approaches to studying potassium channels -- Cardiac K+ channels and channelopathies -- Cardiac hERG K+ channel as safety and pharmacological target -- Pharmacology of A-type K+ channels -- Kv7 channels and hyperexcitability disorders -- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain -- Potassium channels in cancer -- Kir channel molecular physiology, pharmacology and therapeutic implications -- The pharmacology of ATP-sensitive K+ channels (KATP) -- Calcium-activated K+ channels (KCa) and therapeutic implications -- The Pharmacology of two-pore domain potassium channels -- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits -- Peptide toxins targeting KV channels -- Therapeutic antibodies targeting potassium ion channels.
    Abstract: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. .
    Type of Medium: Online Resource
    Pages: VIII, 545 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030840525
    Series Statement: Handbook of Experimental Pharmacology, 267
    URL: https://doi.org/10.1007/978-3-030-84052-5
    DOI: 10.1007/978-3-030-84052-5
    DDC: 615
    Language: English
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  • 4
    Online Resource
    Online Resource
    Network Pharmacology (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Bioinformatics. ; Pharmacology. ; Pharmacy. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. 'Network Target' Theory and Network Pharmacology -- Chapter 2. Application of Network Pharmacology Based on Artificial Intelligence Algorithm in Drug R & D -- Chapter 3. Commonly used Network Pharmacology Database -- Chapter 4. Commonly used Network Pharmacology Software -- Chapter 5. Network Pharmacology and TCM Modernization Case Studies -- Chapter 6. Network Pharmacology and Modern Drug R & D Cases -- Chapter 7. Drug-based Network Pharmacology Practice Process -- Chapter 8. Disease-based Network Pharmacology Practice Process -- Chapter 9. Drug-disease-based Network Pharmacology Practice Process.
    Abstract: This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
    Type of Medium: Online Resource
    Pages: XVII, 468 p. 163 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811607530
    URL: https://doi.org/10.1007/978-981-16-0753-0
    DOI: 10.1007/978-981-16-0753-0
    DDC: 615
    Language: English
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  • 5
    Online Resource
    Online Resource
    Environment and Female Reproductive Health (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Midwifery. ; Public health. ; Pharmacology. ; Midwifery. ; Public Health.
    Description / Table of Contents: Part I Environmental Harmful Factors -- 1 Introduction to Environmental Harmful Factors -- Part II Female Reproductive Processes and Diseases -- 2 Introduction of Female Reproductive Processes and Reproductive Diseases -- Part III Effects of Environmental Factors on Reproductive Process -- 3 The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality -- 4 Effects of environment and lifestyle factors on premature ovarian failure -- 5 Effects of Environment and Lifestyle Factors on Anovulatory Disorder -- 6 Effects of Cigarette Smoking on Preimplantation Embryo Development -- 7 Toxicical effects of BPDE on dysfunctions of female trophoblast cells -- 8 The Roles of Stress-Induced Immune Response in Female Reproduction -- 9 Effects of Environmental EDCs on Oocyte Quality, Embryo Development and the Outcome in Human IVF Process -- Part IV Effects of Environmental Factors on Reproductive Diseases -- 10 Effects of environmental endocrine-disrupting chemicals on female reproductive health -- 11 Definition and Multiple Factors of Recurrent Spontaneous Abortion -- 12 The Variations of Metabolic Detoxification Enzymes Lead to Recurrent Miscarriage and their Diagnosis Strategy -- Part V Effects of Environmental Factors on Fertility Preservation -- 13 The Effects of Negative Elements in Environment and Cancer on Female Reproductive System.
    Abstract: This book will focus on the harmful effect of environmental toxins on female reproductive health. Reproduction is the basis of the continuation of human beings, and environment is the basis of human survival. However, environmental pollution has become a potential risk factor for human reproductive health, which not only leads to many chronic diseases, but also causes certain harm to reproductive health. Compared to male reproduction, female reproductive process is more complex, the reproductive system is more fragile, and is more vulnerable to be damaged. The aim of this book is to review the research progress, to address the challenges, and to stimulate the development in the direction of environment and female reproductive health.
    Type of Medium: Online Resource
    Pages: XI, 313 p. 13 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813341876
    Series Statement: Advances in Experimental Medicine and Biology, 1300
    URL: https://doi.org/10.1007/978-981-33-4187-6
    DOI: 10.1007/978-981-33-4187-6
    DDC: 615
    Language: English
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  • 6
    Online Resource
    Online Resource
    Organic Cation Transporters in the Central Nervous System (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Molecular biology. ; Pharmacology. ; Human Physiology. ; Molecular Biology.
    Description / Table of Contents: General Overview of Organic Cation Transporters in Brain -- Organic Cation Transporter Expression and Function in the CNS -- Genetic and Epigenetic Regulation of Organic Cation Transporters -- Experimental Methods for Investigating Uptake 2 Processes In Vivo -- Substrates and inhibitors of OCTs and PMAT and therapeutic implications -- Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications -- Organic Cation Transporters in Brain Catecholamine Homeostasis -- The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances -- Organic Cation Transporters in Psychiatric Disorders -- Organic Cation Transporters and Nongenomic Glucocorticoid Action -- Brain Plasma Membrane Monoamine Transporter in Health and Disease -- Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications -- Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery.
    Abstract: Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 328 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030829841
    Series Statement: Handbook of Experimental Pharmacology, 266
    URL: https://doi.org/10.1007/978-3-030-82984-1
    DOI: 10.1007/978-3-030-82984-1
    DDC: 615
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  • 7
    Online Resource
    Online Resource
    The Carbonic Anhydrases: Current and Emerging Therapeutic Targets (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    URL: https://doi.org/10.1007/978-3-030-79511-5
    DOI: 10.1007/978-3-030-79511-5
    DDC: 615
    Language: English
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  • 8
    Online Resource
    Online Resource
    Pharmacology of the WNT Signaling System (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Physiology. ; Oncology. ; Neurosciences. ; Developmental biology. ; Pharmacology. ; Physiology. ; Oncology. ; Neuroscience. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Pharmacological thinking in WNT signaling -- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically -- WNTs on exosomes -- Strategies to target LRPs in WNT signaling -- Targeting the receptor tyrosine kinase ROR1 by small molecules -- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors -- Disheveled proteins as crucial mediators of WNT signaling -- Destruction complex and regulation of CTNNB1 -- Strategies to therapeutically target WNT/PCP like signaling in disease -- Mining natural compounds to target WNT signaling - from mushrooms to corals -- FZD7 as a therapeutic target in intestinal cancer -- Targeting oncogenic WNT signaling with WNT derived peptides -- Targeting WNT signaling in lung pathology -- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting -- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy? -- Targeting WNT signaling as a risk.
    Abstract: This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.
    Type of Medium: Online Resource
    Pages: VIII, 422 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030854997
    Series Statement: Handbook of Experimental Pharmacology, 269
    URL: https://doi.org/10.1007/978-3-030-85499-7
    DOI: 10.1007/978-3-030-85499-7
    DDC: 615
    Language: English
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  • 9
    Online Resource
    Online Resource
    The Art of Carbohydrate Analysis (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Chemistry, Organic. ; Food science. ; Biotechnology. ; Pharmacology. ; Organic Chemistry. ; Food Science. ; Biotechnology.
    Description / Table of Contents: Chapter 1 The World of Carbohydrates -- Chapter 2 Basic Knowledge of Glycobiology -- Chapter 3 Carbohydrates involved in Diseases -- Chapter 4 Detection of Carbohydrate by Colorimetric Methods -- Chapter 5. Analytical Techniques to Study Carbohydrates -- Chapter 6 Monosaccharide Composition Analysis -- Chapter 7 Carbohydrate Analysis of Glycoconjugates -- Chapter 8 Structural Characterization of Released Glycans -- Chapter 9 Analysis of Sialic Acids -- Chapter 10 Carbohydrate Microarray Technology -- Chapter 11 Analysis of Carbohydrates by Mass Spectrometry -- Chapter 12 Analysis of Carbohydrates by Nuclear Magnetic -- Chapter 13 Glycobioinformatics -- Chapter 14 Concluding Remarks. .
    Abstract: The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.
    Type of Medium: Online Resource
    Pages: XXV, 350 p. 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030777913
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    URL: https://doi.org/10.1007/978-3-030-77791-3
    DOI: 10.1007/978-3-030-77791-3
    DDC: 615
    Language: English
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  • 10
    Online Resource
    Online Resource
    Structure and Health Effects of Natural Products on Diabetes Mellitus (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Botanical chemistry. ; Bioorganic chemistry. ; Pharmacology. ; Plant Biochemistry. ; Bioorganic Chemistry.
    Description / Table of Contents: Chapter 1. Introduction of diabetes melitus and future prospects of natural products on diabetes melitus -- Chapter 2. Anoverview of hypoglycemic modern drugs -- Chapter 3. An overview of hypoglycemic biological drugs -- Chapter 4. An overview of hypoglycemic traditionaldrugs -- Chapter 5. Glycosides from natural sources in the treatment of diabetes mellitus -- Chapter 6. Isolation and Structure Elucidation of Hypoglycemic Compounds -- Chapter 7. Structural Characterization and Health Effects of Polysaccharides from Momordica charantia on Diabetes Mellitus -- Chapter 8. Effects of polysaccharides on reducing blood glucose based on gut microbiota alteration -- Chapter 9. An Overview of Polysaccharides and the influencefactors of Hypoglycemic Activity -- Chapter 10. Plant Secondary Metabolites with α-Glucosidase Inhibitory Activity. - Chapter 11. Rhinacanthin-C and Its Potential to Control Diabetes Mellitus -- Chapter 12. Regeneration of beta cells by inhibition of pro-apoptotic proteins through phytocompound in STZ induced diabetic albino wistar rats-invivo and insilico approach. - Chapter 13. Nitrogenous Compounds from Plant Origin in Management of -- Chapter 14. Plant Alkaloids with Antidiabetic Potential -- Chapter 15. The role of Alkaloids in the Management of Diabetes Mellitus -- Chapter 16. Traditional Indian Herbs for the Management of Diabetes Mellitus and their Herb-Drug Interaction Potentials: An Evidence-Based Review -- Chapter 17. Role of Micronutrients and Trace elements in Diabetes mellitus: A Review.
    Abstract: The purpose of this book is to introduce the classified chemical components of hypoglycemic compounds in natural products, summarize the recent research progress of natural products with hypoglycemic activity in the past 20 years, and provide the original analysis and development opinions of relevant scholars. Hypoglycemic compounds are to target diabetes mellitus, an important public health problem, one of four priority noncommunicable diseases (NCDs) targeted for action by world leaders. Diabetes mellitus is a common endocrine and metabolic disease, which not only causes physiological damage to patients' kidneys, cardiovascular and cerebrovascular vessels, peripheral blood vessels, nerves and eyes, but also causes mental and psychological pressure to patients. Due to the evidence that traditional medicine and natural herbal formula have advantages in treating diabetes, natural products with hypoglycemic activity have been studied extensively in recent years and have been accepted by many scholars all over the world. This book focuses on the progress on the study of the structure, hypoglycemic activities, structure-activity relationships and mechanism of a wide range of polysaccharides, flavonoids, saponins, alkaloids, terpenoids, polyphenols and other constituents. It will help students and researchers to understand current approaches and progress in the treatment of diabetes with natural products, which may also be beneficial to develop new hypoglycemic drugs.
    Type of Medium: Online Resource
    Pages: VIII, 307 p. 85 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811587917
    URL: https://doi.org/10.1007/978-981-15-8791-7
    DOI: 10.1007/978-981-15-8791-7
    DDC: 615
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  • 11
    Online Resource
    Online Resource
    Evidence Based Validation of Traditional Medicines : A comprehensive Approach (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medical microbiology. ; Medicinal chemistry. ; Pharmacovigilance. ; Pharmacology. ; Medical Microbiology. ; Medicinal Chemistry. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: Chapter 1. Global Approach for Drug Discovery and Development from Indian Traditional Medicine -- Chapter 2. Bioactive Natural Leads TargetingCancer Cell Metabolism -- Chapter 3. Omics Technologies and Development of Anti-diabetic Therapies from Prospective Natural Products -- Chapter 4. Amaryllidaceae Alkaloids as Anti-inflammatory Agents Targeting Cholinergic Anti-inflammatory Pathway: Mechanisms and Prospects -- Chapter 5. Neurodegenerative Diseases and Small Molecule Protein Chaperone Activator of Natural Origin -- Chapter 6. Role of Phytomolecules on the Basic Biology of Aging -- Chapter 7. Role of phytomedicine in alleviating oxidative stress mediated vascular complications in diabetes -- Chapter 8. Plant Based -Secretase (BACE-1) Inhibitors: A Mechanistic Approach to Encounter Alzheimer's Disorder -- Chapter 9. Bioactive Compounds of Mangroves as Potent Drug and in Nanoparticle Synthesis - Play a Pivotal Role in Combating Human Pathogens. Chapter 10. Medicinal Plants: A Rich Source of Bioactive Molecules Used in Drug Development -- Chapter 11. Cell-based Assays in Natural Product-based Drug Discovery -- Chapter 12. Allelochemicals: An Emerging Tool for Weed Management -- Chapter 13. Secondary Metabolites of Higher Plants as Green Preservatives of Herbal Raw Materials and Their Active Principles During Postharvest Processing -- Chapter 14. Importance of Chromatography Techniques in Phytomedicine Research -- Chapter 15. Reverse Pharmacology – A Tool for Drug Discovery From Traditional Medicine -- Chapter 16. Role of Modern Biological Techniques in Evidence-Based Validation of Ayurvedic Herbometallic Preparations -- Chapter 17. HPTLC Fingerprinting analysis of Phytoconstituents from Indigenous Medicinal Plants -- Chapter 18. Climate Change,Geographical Location and Other Allied Triggering Factors Modulate the Standardization and Characterization of Traditional Medicinal Plants: AChallenges and Prospect for Phyto-Drug Development -- Chapter 19. Molecular Docking Studies of Plant-Derived Bioactive Compounds: A Comprehensive in silico Standardization Approach -- Chapter 20. Standardization and Quality Evaluation of Botanicals with Special Reference to Marker Components -- Chapter 21. Analytical Standardization of Haridra Formulation by UV-VIS Spectrophotometry and RP-HPLC -- Chapter 22. Ethnobotanical survey: the foundation to evidence based validation of medicinal plants -- Chapter 23. Phytotherapeutics: The Rising Role of Drug Transporters in Herb-Drug Interactions with Botanical Supplements -- Chapter 24. An Insight into Herb Interactions: Clinical Evidence Based Overview -- Chapter 25. Pharmacovigilance of Herbal Medicines: An Overview -- Chapter 26. Herbal Drugs: Efficacy, Toxicity and Safety Issues -- Chapter 27. Herbal Drug Patenting -- Chapter 28. Safety and Regulatory Issues on Traditional Medicine Entrusted Drug Discovery -- Chapter 29. Pharmacovigilance of Herbal Medicine: An Evolving Discipline -- Chapter 30. Toxicity Studies Related to Medicinal Plants -- Chapter 31. Herb-Drug Interactions -- Chapter 32. Plant Based Traditional Herbal Contraceptive Use in India: Safety and Regulatory Issues -- Chapter 33. Traditional Medicine Stability and Pharmacokinetic Issue -- Chapter 34. Pharmacovigilance: Methods in developing the safety and acceptability of traditional medicines -- Chapter 35. Zoopharmacognosy (Plant-Animal Interaction) -- Chapter 36. Significance of Stability and Pharmacokinetic issues in Traditional Medicine -- Chapter 37. Pharmaceutical Formulations Development Based on the Polymers Obtained from Edible Plants: An Excellent Approach for the Betterment in Health Care Services -- Chapter 38. Evaluation of bioactivity of green nanoparticles synthesized from traditionally used medicinal plants: a review -- Chapter 39. Physicochemical, Micromeritics, Biomedical and Pharmaceutical Applications of Assam Bora Rice Starch -- Chapter 40. Natural Excipients in Pharmaceutical Formulations -- Chapter 41. A Wonder Plant Withania: Pharmacological and Chemical Perspectives -- Chapter 42. Immunomodulators and Phyto Drugs -- Chapter 43. Combined Effects of Plant Extracts on Ovarian Cell Functioning -- Chapter 44. Pterocarpussantalinus: A Wonder Gift of Nature -- Chapter 45. Phytochemicals And Investigations On Traditionally Used Medicinal Mushrooms -- Chapter 46. A Review On Investigational Studies Of Marine Macroalgae Spogomorpha Indica L -- Chapter 47. Validation of Traditional Claim of Oxalis debilis Kunth., An Ethnomedicinal Plant from North-eastern Region of India -- Chapter 48. Traditional Herbal Medicine Practiced in Plateau-Fringe and Rarh Districts of West Bengal, India -- Chapter 49. Pharmacology and Mechanisms of Natural Medicine in Treatment of Type 2 Diabetes Mellitus -- Chapter 50. Indian Traditional Herbs and Alzheimer’s Disease: Integrating Ethnobotany and Phytotherapy. .
    Abstract: The demand for traditional medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements and herbal cosmetics etc. is increasing globally due to the growing recognition of these products as mainly non-toxic, having lesser side effects, better compatibility with physiological flora, and availability at affordable prices. In the last century, medical science has made incredible advances all over the globe. In spite of global reorganization and a very sound history of traditional uses, the promotion of traditional medicine faces a number of challenges around the globe, primarily in developed nations. Regulation and safety is the high concern for the promotion of traditional medicine. Quality issues and quality control, pharmacogivilane, scientific investigation and validation, intellectual property rights, and biopiracy are some key issues that restrain the advancement of traditional medicine around the globe. This book contains diverse and unique chapters, explaining in detail various subsections like phytomolecule, drug discovery and modern techniques, standardization and validation of traditional medicine, and medicinal plants, safety and regulatory issue of traditional medicine, pharmaceutical excipients from nature, plants for future. The contents of the book will be useful for the academicians, researchers and people working in the area of traditional medicine. .
    Type of Medium: Online Resource
    Pages: XII, 1151 p. 378 illus., 125 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581274
    URL: https://doi.org/10.1007/978-981-15-8127-4
    DOI: 10.1007/978-981-15-8127-4
    DDC: 615
    Language: English
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  • 12
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    Online Resource
    Emerging Technologies for Nanoparticle Manufacturing (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Nanotechnology. ; Nanochemistry. ; Pharmacology. ; Nanotechnology. ; Nanochemistry.
    Description / Table of Contents: Part 1 Introduction and Biomedical Applications of Nanoparticles -- 1. Introduction to Nanomaterials and Nanotechnology -- 2. Biomedical Applications of Nanoparticles -- Part II-Polymeric Nanoparticles -- 3. Nanocrystallization and Nanoprecipitation Technologies -- 4. Microfluidics Technology for Nanoparticles and Equipment-. 5. Production of Nanocomposites via Extrusion Techniques -- 6. The Use of Supercritical Fluids Technologies for Nanoparticle Production -- 7. Salting out and Ionic Gelation Manufacturing Techniques for Nanoparticles -- 8. Nanogel Synthesis by Irradiation of Aqueous Polymer Solutions -- 9. Cellulose acetate based nanofibers: Synthesis, Manufacturing and Applications -- 10. Production of nanofibers, environmental challenges and solutions -- Part III-Lipid Nanoparticles -- 11. High Pressure Homogenization Techniques for Nanoparticles -- 12. Solvent emulsification evaporation and solvent emulsification diffusion techniques for nanoparticles -- 13. Ultrasound Activated Nanoemulsions -- 14. Multiple Emulsions: Emphasizing on industrial applications -- 15. Membrane techniques for the preparation of nanomaterials -- 16. Self-assembling Lipid Nanoparticles/Nanosystems (SLNN) using Hydrophilic Solvents: Overview and Industrial Uses -- 17. Nanoemulsions – An emerging technology in drug delivery -- Part IV- Metallic Nanoparticles -- 18. Manufacturing techniques for carbon nanotubes, gold nanoparticles and silver nanoparticles -- 19. Radio frequency (RF) plasma-based Synthesis of metallic Nano particles for Biomedical Application -- 20. Techniques for accurate sizing of nanoparticles -- 21. Silver nanoparticles synthesis from cyanobacteria: Environmental and biomedical applications -- 22. Selenium Nanoparticles: Green Synthesis and Exploitation -- Part V- Quality control for nanoparticles -- 23. Practical guidelines for the characterization and quality control of nanoparticlesin the pharmaceutical industry -- Part VI-Challenges in scale-up production of nanoparticles -- 24. Nanomedicine Scale-Up Technologies: Feasibilities and Challenges -- 25. Patent survey on recent technology for nanoparticles -- Part VII-Injectable Nanosystems -- 26. Injectable Nanosystems and Inherent Nano-Serum Interactions -- Part VIII- Future directions and challenges -- 27. Current Challenges and Future Directions in Nanomedicine.
    Abstract: This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges. .
    Type of Medium: Online Resource
    Pages: XV, 611 p. 155 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030507039
    URL: https://doi.org/10.1007/978-3-030-50703-9
    DOI: 10.1007/978-3-030-50703-9
    DDC: 615
    Language: English
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  • 13
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    Antiviral Drug Discovery and Development (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Pharmacy. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Biotechnology.
    Description / Table of Contents: 1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .
    Abstract: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
    Type of Medium: Online Resource
    Pages: XI, 357 p. 142 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602672
    Series Statement: Advances in Experimental Medicine and Biology, 1322
    URL: https://doi.org/10.1007/978-981-16-0267-2
    DOI: 10.1007/978-981-16-0267-2
    DDC: 615
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  • 14
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    The Physical Geography of Mongolia (2021)
    Cham :Springer International Publishing :
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    Keywords: Physical geography. ; Water. ; Hydrology. ; Environment. ; Biodiversity. ; Climatology. ; Physical Geography. ; Water. ; Environmental Sciences. ; Biodiversity. ; Climate Sciences.
    Description / Table of Contents: 1. General Characteristics of Geography Of Mongolia -- 2. Historical Geography: Administrative Division and Research in Physical Geography of Mongolia -- 3. The Relief And Geomorphological Characteristics of Mongolia -- 4. Climate and Climate Change of Mongolia -- 5. Hydrography of Mongolia -- 6. Glacier of Mongolia -- 7. Permafrost in Mongolia -- 8. Soil of Mongolia -- 9. Biogeographical Characteristics of Mongolia -- 10. Division of the Physiographic and Natural Regions in Mongolia -- 11. Land Use and Nature Conservation in Mongolia.
    Abstract: This book gives the most detailed and comprehensive physico-geographical overview of the very unique country of Mongolia. The country offers diverse geographical features and natural landscapes combined with a long history. This book offers integrated and systematical research on the geophysical characteristics of Mongolia with an academic orientation. It provides the readers with general knowledge of the physical geography of Mongolia as well as new results of the latest research. The volume consists of 11 chapters, each written by field experts, with contributions from scientific researchers from Mongolia. The topics covered: geological and geomorphological characteristics and processes, landscapes and landforms, climate and climate change, hydrology, glaciers and permafrost, soils, environmental changes, biodiversity and many other aspects of physical geography in Mongolia. The book appeals to researchers and students of geography and related fields and can serve as a guide for field trips to Mongolia or basic literature for research projects.
    Type of Medium: Online Resource
    Pages: XXII, 218 p. 122 illus., 113 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030614348
    Series Statement: Geography of the Physical Environment,
    URL: https://doi.org/10.1007/978-3-030-61434-8
    DOI: 10.1007/978-3-030-61434-8
    DDC: 910.02
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  • 15
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    Nordic Perspectives on the Responsible Development of the Arctic: Pathways to Action (2021)
    Cham :Springer International Publishing :
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    Keywords: Physical geography. ; Social sciences. ; Humanities. ; Environment. ; Political sociology. ; Sustainability. ; Geography. ; Physical Geography. ; Humanities and Social Sciences. ; Environmental Sciences. ; Political Sociology. ; Sustainability. ; Regional Geography.
    Description / Table of Contents: Chapter 1. An Introduction (Douglas C. Nord ) -- Chapter 2. NordForsk as a Facilitator of Integrated Research on the Arctic (Gunnel Gustafsson) -- Chapter 3. CLINF: Climate Change Effects on the Epidemiology of Infectious Diseases and the Associated Impacts on Northern Societies( Birgitta Evengård and Tomas Thierfelder ) -- Chapter 4. CLINF: An Integrated Project Design(Tomas Thierfelder and Birgitta Evengård ) -- Chapter 5.Environmental Data Modeling for CSI Research in the Arctic(Gia Destouni, Zarah Kalantari, Shaun Quegan, Dieder Leibovic, Juha Lemmetyinen, Jaakko Ikonen) -- Chapter 6 .Reindeer Herding and Coastal Pastures: Adaption to Multiple Stressors and Cumulative Effects(Grete Hovelsrud, Camilla Risvoll, Jan Åge Riseth, Hans Tømmervik, Anna Omazic, Ann Albihn ) -- Chapter 7.The ARCPATH Project—Assessing Risky Environments and Rapid Change:Research on Climate, Adaptation and Coastal Communities in the North Atlantic Region (Astrid E.J. Ogilvie, Yongqi Gao, Niels Einarsson, Noel Keenlyside, Leslie King ) -- Chapter 8 .The Climate Model: An ARCPATH Tool to Understand and Predict Climate Change (Shuting Yang, Yongqi Gao, Koenigk Torben, Noel Keenlyside, Francois Counillon ) -- Chapter 9. Whale Ecosystem Services and Co-production Processes Underpinning Human Wellbeing in the Arctic: Case Studies from Greenland, Iceland and Norway(Laura Malinauskaite, David Cook, Brynhildur Daviծsdóttir, Helga Ögmundardóttir) -- Chapter 10. "Small Science”: Community Engagement and Local Research in an Era of Big Science Agendas (Catherine Chambers, Leslie King, David Cook, Laura Malinauskaite, Margaret Willson, Astrid E. J. Ogilvie, Niels Einarsson) -- Chapter 11. Project ReiGN: Reindeer Husbandry in a Globalizing North—Resilience, Adaptations and Pathways to Action (Øystein Holand, Jon Moen, Jouko Kumpula, Annette Löf, Sipra Rasmus, Knut Røed ) -- Chapter 12 .What Drives the Number of Semi-Domesticated Reindeer? Pasture Dynamics and Economic Incentives in Fennoscandian Reindeer Husbandry (Annti-Juhani Pekkarinen, Juoko Kumpula and Olli Tahvonen) -- Chapter 13. Reindeer Herders as Stakeholders or Right- Holders: Introducing a Social-Equity Based Conceptualization Relevant for Indigenous and Local Communities (Simo Sarkki, Hannu Heikkinen and Annette Löf) -- Chapter 14. Working Together: Reflections on a Transdisciplinary Effort of Co-producing Knowledge on Supplementary Feeding in Reindeer Husbandry Across Fennoscandia (Tim Horstkotte, Élise Lépy and Camilla Risvoll) -- Chapter 15. Is There Such a Thing As “Best Practice”? Exploring the Extraction/Sustainability Dilemma in REXSAC ( Sverker Sörlin) -- Chapter 16 .When Mines Go Silent: Exploring the Afterlives of Extraction Sites (Dag Avango and Gunhild Rosqvist) -- Chapter 17 Bringing Emotions Back In—Affective Approaches to Resource Extraction(Frank Sejersted and Kirsten Thisted) -- Chapter 18 .The Challenge of Synthesis: Lessons from Arctic Climate Predictions: Pathways to Resilient, Sustainable Societies (Leslie King and Astrid E.J. Ogilvie) -- Chapter 19. Assessment and Evaluation in Arctic Research—Where Do We Come From, and Where Are We Going? (Andre van Amstel, Amy Lauren Lovecraft, Maureen Biermann, Roberta Marinelli and Douglas Nord) -- Chapter 20 . Findings and Conclusions—Pathways for Action (Douglas Nord).
    Abstract: This book investigates the multifaceted nature of change in today’s Nordic Arctic and the necessary research and policy development required to address the challenges and opportunities currently faced by this region. It focuses its attention on the recent efforts of the Nordic community to create specialized Centers of Excellence in Arctic Research in order to facilitate this process of scientific inquiry and policy articulation. The volume seeks to describe both the steps that lead to this decision and the manner in which this undertaking as evolved. The work highlights the research efforts of the four Centers and their investigations of a variety of issues including those related to ecosystem and wildlife management, the revitalization resource dependent communities, the emergence of new climate-born diseases and the development of adequate modeling techniques to assist northern communities in their efforts at adaptation and resilience building. Major discoveries and insights arising from these and other efforts are detailed and possible policy implications considered. The book also focuses attention on the challenges of creating and supporting multidisciplinary teams of researchers to investigate such concerns and the methods and means for facilitating their collaboration and the integration of their findings to form new and useful perspectives on the nature of change in the contemporary Arctic. It also provides helpful consideration and examples of how local and indigenous communities can be engaged in the co-production of knowledge regarding the region. The volume discusses how such research findings can be best communicated and shared between scientists, policymakers and northern residents. It considers the challenges of building common concern not just among different research disciplines but also between bureaucracies and the public. Only when this bridge-building effort is undertaken can true pathways to action be established. .
    Type of Medium: Online Resource
    Pages: XXV, 448 p. 47 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030523244
    Series Statement: Springer Polar Sciences,
    URL: https://doi.org/10.1007/978-3-030-52324-4
    DOI: 10.1007/978-3-030-52324-4
    DDC: 910.02
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  • 16
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    Geochemical Behavior of Levoglucosan in Tibetan Plateau Glacier Snow and Ice (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Physical geography. ; Atmospheric science. ; Geochemistry. ; Physical Geography. ; Atmospheric Science. ; Geochemistry.
    Description / Table of Contents: Research background -- Introduction of the Zangsegangri ice core -- Levoglucosan analytical method -- Modern processes of levoglucosan in Tibetan glaciers -- Fire records in the Zangsegangri ice core -- Summary and conclusions.
    Abstract: This book focuses on geochemical behavior and ancient records of the specific biomarker levoglucosan in Tibetan glaciers, Based on samples from the Zangsegangri (ZSGR) ice cores obtained from the central Tibetan Plateau, it presents annually resolved levoglucosan records and fire changes over the past 430 years. It also discusses the interaction between fire, climate change, and human activities. This is the first effort to reconstruct annual resolution fire records in Tibetan ice, providing crucial information and substantially improved analytical methods toward a better understanding of past fire changes.
    Type of Medium: Online Resource
    Pages: XIV, 63 p. 26 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811579738
    Series Statement: Springer Theses, Recognizing Outstanding Ph.D. Research,
    URL: https://doi.org/10.1007/978-981-15-7973-8
    DOI: 10.1007/978-981-15-7973-8
    DDC: 910.02
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  • 17
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    Diversified Cropping Pattern and Agricultural Development : A Case Study from Malda District, India (2021)
    Cham :Springer International Publishing :
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    Keywords: Physical geography. ; Agriculture. ; Human geography. ; Subsistence farming. ; Physical Geography. ; Agriculture. ; Human Geography. ; Subsistence Agriculture.
    Abstract: This book examines how crop diversification strategies can help to ensure sustainable agricultural development across different land-size categories, with a focus on Malda District in West Bengal, India. Using Malda as the study area, a region with nearly 4 million people, the book assesses the extent, pattern, factors and future of crop diversification and its contribution to the development of agriculture in Malda and in India as a whole. The work presents data from 1995-2015 concerning changing cropping patterns at various land-size distributions, and analyzes the information over the twenty year period to understand the link between crop diversification and agricultural development, in order to combat major agricultural issues and make suitable policy recommendations at micro (rural) and macro (urban) levels of agricultural planning. The study is a unique contribution to the field of agricultural geography, and will be of use to students and researchers, as well as government organizations, city/community planners and agriculture managers.
    Type of Medium: Online Resource
    Pages: XXXVI, 285 p. 116 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030557287
    URL: https://doi.org/10.1007/978-3-030-55728-7
    DOI: 10.1007/978-3-030-55728-7
    DDC: 910.02
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  • 18
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    Water, Cryosphere, and Climate Change in the Himalayas : A Geospatial Approach (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Water. ; Hydrology. ; Geographic information systems. ; Climatology. ; Environment. ; Natural disasters. ; Physical Geography. ; Water. ; Geographical Information System. ; Climate Sciences. ; Environmental Sciences. ; Natural Hazards.
    Description / Table of Contents: 1. Application of Geospatial Techniques for Monitoring the Cryospheric Elements of Glacier System in Indian Himalayan Region (IHR) -- 2. Snowmelt Runoff Forecasting in Himalayan Basins using Remote Sensing Inputs -- 3. Understanding Climate Change and its Impacts with Special Reference to India -- 4. Snow, Glacier and Glacier Lake Mapping and Monitoring Using Remote Sensing Data -- 5. Remote Sensing Based Assessment of Glacier Resources in Parts of Ladakh Mountain Range, A Trans-Himalayan Region -- 6. Geodetic Mass Balance Estimation for Bada Shigri Glacier and Samudra Tapu Glacier in Chandra basin -- 7. Analysis of Snow Dynamics in Beas River Basin, Western Himalaya Using Combined Terra-Aqua MODIS Improved Snow Product and In-Situ Data during 21st Century -- 8. Inventory of Moraine Dammed Lakes in Satluj, Ravi, Chenab, and Beas Basins using IRS- LISS III Satellite Data in the Western Himalayan Region of Himachal Pradesh, India -- 9. Late Quaternary Glacial Geomorphology of Kashmir Valley, NW Himalayas: A Case Study of the Sind Basin -- 10. Snow Cover and Land Surface Temperature Assessment of Mana Basin Using MODIS Satellite Data -- 11. Seasonal ground water fluctuation monitoring using GRACE satellite technology over Punjab and Haryana during 2005 – 2015 -- 12. Importance of regulating transboundary aquifers in the world with special reference to Indian subcontinent: A review -- 13. Chemical Weathering in Jhelum River and its Tributaries, Kashmir Basin, Western Himalaya -- 14. Groundwater Storage Assessment Using Effective Downscaling Grace Data in Water-Stressed Regions of India -- 15. Water quality of Himalayan Rivers in Uttarakhand -- 16. Study of Solute Sources and hydrochemical Analysis of Meltwater Draining from the Gangotri Glacier, Garhwal Himalaya, India -- 17. Geochemical Characterization and Evolution of Groundwater in Parts of Kashmir Valley, Western Himalaya -- 18. Delineation of Groundwater Potential Recharge Zone Using Remote Sensing and GIS techniques – A Case Study of Rampur Tehsil, Shimla District, Himachal Pradesh India -- 19. Geospatial Approach for Water Quality Index Mapping for Drinking Purpose in Guna District, Madhya Pradesh, India, Madhya Pradesh, India -- 20. Application of Environmental Isotopes and Hydrogeochemistry in Groundwater Management – A Case Study of Bringi Watershed, Kashmir Himalayas, India.
    Abstract: This edited book summarizes numerous research studies on remote sensing and GIS of natural resource management for the Himalaya region done by Indian Institutions and Universities over the last decade. It gives an overview of hydrometeorological studies on Himalayan water resources and addresses concerns in the development of water resources in this region, which is dealing with an increased pressure in population, industrialization and economic development. While the source of some of the major rivers of India are found in the Himalayas, the glaciers and water bodies in the region are continuously shrinking leading to a depletion of water and deterioration of water quality. This is affecting a population of up to 2.5 billion people. The ecosystems have been under threat due to deforestation, loss of biodiversity, expansion of agriculture and settlement, overexploitation of natural resources, habitat loss and fragmentation, poaching, mining, construction of roads and large dams, and unplanned tourism. Spaceborne remote sensing with its ability to provide synoptic and repetitive coverage has emerged as a powerful tool for assessment and monitoring of the Himalayan resources and phenomena. This work serves as a resource to students, researchers, scientists, professionals, and policy makers both in India and on a global level. .
    Type of Medium: Online Resource
    Pages: XVI, 355 p. 247 illus., 230 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679323
    Series Statement: Geography of the Physical Environment,
    URL: https://doi.org/10.1007/978-3-030-67932-3
    DOI: 10.1007/978-3-030-67932-3
    DDC: 910.02
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  • 19
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    Ocean Literacy: Understanding the Ocean (2021)
    Cham :Springer International Publishing :
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    Keywords: Physical geography. ; Ecology . ; Oceanography. ; Environmental education. ; Water. ; Hydrology. ; Physical Geography. ; Ecology. ; Ocean Sciences. ; Environmental and Sustainability Education. ; Water.
    Description / Table of Contents: Part I: General on ocean literacy -- Ocean literacy: background, future drivers and opportunities -- Ocean literacy – From a ripple to wave -- A framework for the assessment of the effectiveness of ocean literacy initiatives -- Exploring and exploiting deep ocean, space -- Ocean literacy – In the context of naming of seas. Case study: The sea between Korea and Japan -- Part II: Education -- Design-based implementation research for exploring the ocean. A geographical perspective -- Innovative education strategies to advance ocean literacy -- Education under sail: Could sail training be the quintessential alternative education space for ocean Literacy?- Part III: Applications -- The importance of Ocean literacy in the Mediterranean Region - Steps towards blue sustainability.
    Abstract: This book provides an original review of Ocean Literacy as a component of public policy in Europe and beyond. The impact of the ocean on human activities is one of the most significant environmental issues facing humanity. By offering valuable insights into the interrelationships between geography, environment, marine science and education, the book explores key issues relating to the future of our planet and the way people respond to them. This volume discusses concepts concerning citizenship education and co-creation and the role of public policy and different international initiatives in raising awareness and mitigating the effects of over-use and misuse of valuable resources. A range of innovative projects are presented and evaluated from the local to national and global levels.This book advances knowledge and provides a picture of these advances, presents the issues and challenges, including the important role that geography education and geographical awareness could play in advancing the case for Ocean Literacy. This crossdisciplinary book appeals to students and scientists as well as professionals and practitioners in geography, environmental and marine sciences, international policy and many related fields.
    Type of Medium: Online Resource
    Pages: XXIV, 294 p. 129 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030701550
    Series Statement: Key Challenges in Geography, EUROGEO Book Series,
    URL: https://doi.org/10.1007/978-3-030-70155-0
    DOI: 10.1007/978-3-030-70155-0
    DDC: 910.02
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  • 20
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    Introduction to Cryospheric Science (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Physical geography. ; Water. ; Hydrology. ; Geomorphology. ; Atmospheric science. ; Sustainability. ; Physical Geography. ; Water. ; Geomorphology. ; Atmospheric Science. ; Sustainability. ; Earth System Sciences.
    Description / Table of Contents: Cryosphere and Cryospheric Science -- Classification and geographical distribution of cryosphere -- Formation and development of cryosphere -- Physical properties of the cryosphere -- Chemical characteristics of the cryosphere -- Climatic and environmental record in cryosphere -- Cryospheric evolutions at different time-scales -- Interactions between cryosphere and other spheres -- Cryospheric changes and sustainable development -- Cryosphere model and cryosphere change projection -- Field observations and experiments for cryospheric science.
    Abstract: This book introduces systematically the cryospheric science, covering the formation, development, evolution, and research methods of each component of the cryosphere, the interaction between the cryosphere and the other spheres of the climate system and the anthroposphere, and the hot topics of social and economic sustainable development and geopolitics. The authors are world-renowned experts and scientists working in the related fields. They have a deep understanding and accurate grasp of the basic theory, evolution mechanism, and international frontiers of the cryosphere, as well as rich teaching experience, which makes this book suitable also as textbook for graduate students. It is also the first book that introduces the knowledge of cryospheric science systematically. In addition to theoretical knowledge, the book also introduces field work and experimental analysis. It should be of interests for the scholars and graduate student working in the fields of geography, hydrology, geology, geomorphology, atmosphere, ecology, environment, oceanography, and regional economic and social sustainable development.
    Type of Medium: Online Resource
    Pages: XIII, 422 p. 159 illus., 111 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811664250
    Series Statement: Springer Geography,
    URL: https://doi.org/10.1007/978-981-16-6425-0
    DOI: 10.1007/978-981-16-6425-0
    DDC: 910.02
    Language: English
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    Online Resource
    Therapeutic Landscapes : An Interdisciplinary Perspective on Landscape and Health (2021)
    Wiesbaden :Springer Fachmedien Wiesbaden :
    Details
    Keywords: Physical geography. ; Landscape architecture. ; Quality of life. ; Physical Geography. ; Landscape Architecture. ; Quality of Life Research.
    Description / Table of Contents: Therapeutic landscapes, introduction to a concept of health-promoting places -- on the concept of landscape and health -- human-place relationships - landscape preferences, landscape and forests as health resources.
    Abstract: Joachim Rathmann presents the interdisciplinary relationships between landscapes and health. Nature is to be regarded as an elementary health resource, because movement in near-natural surroundings has demonstrably positive influences on human health and is summarized in many ways in the concept of "therapeutic landscapes". Natural areas offer an important resource for strengthening health, especially to an aging society, which can also be measured economically. The author presents natural science, social science, and humanities research in a clear, understandable, and concise manner for a broad readership. At the same time he gives suggestions for a conscious handling of the sensitive resource landscape and for a regular observation of nature. This springer essential is a translation of the original German 1st edition essentials, Therapeutische Landschaften by Joachim Rathmann, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2020. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. The contents · Therapeutic landscapes, introduction to a concept of health-promoting places · On the concept of landscape and health · Person-place bonds · Landscape preferences, landscape and forests as a health resource The target groups Students and lecturers of landscape planning, nature conservation, geography, health sciences and environmental psychology, -medicine as well as -pedagogy Professionals in these fields and in landscape architecture, environmental economics, and gerontology The author Dr. Joachim Rathmann did his PhD on climate change in southern hemispheric Africa and teaches and does postdoctoral research on ecosystem services at the University of Augsburg. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Type of Medium: Online Resource
    Pages: VII, 48 p. 3 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783658338480
    Series Statement: Springer essentials,
    URL: https://doi.org/10.1007/978-3-658-33848-0
    DOI: 10.1007/978-3-658-33848-0
    DDC: 910.02
    Language: English
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  • 22
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    Online Resource
    Macro, Micro, and Nano-Biosensors : Potential Applications and Possible Limitations (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Biomaterials. ; Life sciences. ; Pharmaceutical chemistry. ; Pharmacology. ; Biomaterials. ; Life Sciences. ; Pharmaceutics.
    Description / Table of Contents: Macro-, micro- and nanosensors based on biological / chemical materials -- Bactericidal, fungicidal and immunomodulating activity of nano-surfaces -- Enzymatic Tissue Biotests (MAO and AChE biotests) and Bioindicators -- Is it possible to detect less than one bacterial cell? -- SERS for bacterial, virus and protein bio-sensing -- Biosensors for virus detection -- Specific immobilization of rotaviruses for atomic force microscopy with using Langmuir antibody films based on amphiphilic polyelectrolytes -- Fluorimetric and SERS sensor systems for diagnostics and monitoring of catecholamines-dependent diseases -- Enhanced sensitivity rapid tests for the detection of sepsis marker procalcitonin -- Analytical capabilities of some biosensors for the determination of drugs -- Electrochemical DNA sensors based on nanostructured polymeric materials for determination of antitumor drugs -- Variants of amperometric biosensors in the determination of some micotoxins: analytical capabilities -- New class of diagnostic systems based on polyelectrolyte microcapsules for urea detection -- Bioluminescent nano- and micro-biosensing elements for detection of organophosphorous compounds -- Nano- and microelectrochemical biosensors for determining blood glucose -- Micro-Electrochemical SMBG Biosensor Chip Design Development for Sustainable Mass Production based on the Strategic Platform Patent Map -- Biological Fuel Cells: Applications in Health Service and Ecology -- Recent Trends in Fabrication and Applications of Wearable Bioelectronics for Early-Stage Disease Monitoring and Diagnosis -- Self-powered biosensors in medicine and ecology -- Self-powered implantable biosensors – a review of recent advancements and future perspectives.
    Abstract: This book includes an international group of researchers who present the latest achievements in the field of enzyme, immune system, and microbial and nano-biosensors. It highlights the experimental evidence for formation of biological fuel cells (BFCs)-which has a dual purpose – as a device that produces electricity and the systems which produce it simultaneously cleaning up the environment from polluting organic compounds. Considering the work in the field of macro, micro and nano-biosensors, considerable attention is paid to the use of nanomaterials for the modification of working electrodes. Nanomaterials in some cases can significantly improve the parameters of analytical systems. Readers will be interested in the projection of the presented theoretical and experimental materials in the field of practical application of modern analytical developments. The presented results in many cases imply the possibility of using the created models of macro, micro and nano-biosensors, and biofuel elements in the field of health, and protection/restoration of the environment. It includes information about all existing types of transducers of signals in biosensors – electrochemical, optical and quantum-optics, thermoelectric, data of atomic force microscopy, piezoelectric, and more. On the basis of these principles, descriptions are given about the functioning of macro, micro and nano- biosensors for the detection of compounds used in medicine, detection of compounds that clog the environment, and thus affect human health, for compounds that are potentially the basis for the production of drugs, for the selection of compounds that have medicinal activity, for immunodetection, and to assess the quality of food. These questions form the basis of research carried out in the field of biosensors in the world. Since the described models of biosensors have high sensitivity, high measurement speed and selectivity, the described results attract the attention of both the ordinary reader and business class specialists who create and implement analytical technologies. This book is very useful for researchers in life sciences, chemical sciences, physics, and engineering. In addition, it will be useful for the persons working in industry. Advanced technologies specialists will be attracted by the novelty of the proposed solutions and their relevance and ease of implementation. Since the studies contain sections describing the parameters of different biosensors, BFCs, they are easily navigated into assessing the effectiveness of the practical use of the proposed device. The relevant sections indicate such characteristics as detection ranges, life span, type of biological material used, the method of formation of the bio-receptor part. These parameters are of interest to both developers of new models of biosensors and BFC, and their manufacturers.
    Type of Medium: Online Resource
    Pages: XVIII, 415 p. 122 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030554903
    URL: https://doi.org/10.1007/978-3-030-55490-3
    DOI: 10.1007/978-3-030-55490-3
    DDC: 615
    Language: English
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  • 23
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    Online Resource
    Botulinum Toxin Therapy (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Psychiatry. ; Neurosciences. ; Pharmacology. ; Psychiatry. ; Neuroscience.
    Description / Table of Contents: Part 1. Basic Science -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- The History of Botulinum Toxins in Medicine: A Thousand Year Journey -- Botulinum Neurotoxins: Mechanism of Action -- Manufacturing and Clinical Formulations of Botulinum Neurotoxins -- Novel Native and Engineered Botulinum Neurotoxins -- Part 2. Clinical Practice -- Clinical Pharmacology of Botulinum Toxin Drugs -- The Use of Botulinum Toxin for Treatment of the Dystonias -- The Use of Botulinum Toxin for Treatment of Spasticity -- Use of Botulinum Toxin in Ophthalmology -- Hyperhidrosis and Aesthetics -- Use of Botulinum Toxin in Genitourinary System -- Gastrointestinal Uses of Botulinum Toxin -- The Use of Botulinum Toxin in the Management of Headache Disorders -- Botulinum Toxin and Pain -- The Use of Botulinum Toxin for Treatment of Depression.
    Abstract: In a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases. Part 1 of the book reviews the basic science of botulinum toxins including advances in our understanding of the molecular structure and mechanism of action of botulinum toxins. This section also discusses the manufacturing and formulation of botulinum toxins for clinical use and the development of novel therapeutic toxins for the future. Part 2 reviews the use of botulinum toxins in clinical practice. It discusses the clinical pharmacology of botulinum toxin drugs and their use in a wide variety of clinical conditions including headache, spasticity, pain, disorders of the genitourinary and gastrointestinal tract, strabismus, and medical aesthetics.
    Type of Medium: Online Resource
    Pages: VIII, 289 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663063
    Series Statement: Handbook of Experimental Pharmacology, 263
    URL: https://doi.org/10.1007/978-3-030-66306-3
    DOI: 10.1007/978-3-030-66306-3
    DDC: 615
    Language: English
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  • 24
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    Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Biotechnology. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Human Physiology. ; Biotechnology. ; Biomedical Research.
    Description / Table of Contents: The effect of curcumin supplementation on pulse wave velocity in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial -- Role of Curcumin in Regulating Long Noncoding RNA Expression in Cancer -- The Effect of Curcumin Phytosome on the Treatment of Patients with Non-alcoholic Fatty Liver Disease: A Double-blind, Randomized, Placebo-Controlled Trial -- Protective effects of curcumin phytosomes against high-fat diet-induced atherosclerosis -- Intravenous Curcumin Mitigates Atherosclerosis Progression in Cholesterol-fed Rabbits -- Updated review on the role of curcumin in gastrointestinal cancers -- Curcumin can bind and interact with CRP: an in silico study -- Antifungal activities of curcumin and difluorinated curcumin against clinical dermatophyte isolates -- Therapeutic Effect of Curcumin in Women with Polycystic Ovary Syndrome Receiving Metformin: A Randomized Controlled Trial -- Effect of Curcumin on Severity of Functional Dyspepsia; a Triple Blinded Clinical Trial -- Possible mechanisms and special clinical considerations of curcumin supplementation in patients with COVID-19 -- Paving the road toward exploiting the therapeutic effects of ginsenosides: an emphasis on autophagy and endoplasmic reticulum stress -- Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: A clinical review -- Plants with anti-addictive potential -- Use of Plant-Derived Natural Products in Sleep Disturbances -- The effects of nutraceuticals and herbal medicine on Candida albicans in oral candidiasis: a comprehensive review -- Pharmacological properties of the plant-derived natural products cannabinoids and implications for cardiovascular health -- Beneficial effects of plant-derived natural products on non-alcoholic fatty liver disease -- Crocin Improves Oxidative Stress in Testicular Tissues of Streptozotocin-Induced Diabetic Rats -- Beneficial Medicinal Plants for Memory and Cognitive Functions Based on Traditional Persian Medicine -- The use of medicinal plants for the treatment of alopecia in the Canon of Avicenna: an evidence-based review -- Ethnobotanical uses, phytochemistry and pharmacology of different Rheum species (Polygonaceae): A review -- Genus Rosa: A review of ethnobotany, phytochemistry and traditional aspects according to Islamic traditional medicine (ITM) -- Ethnobotany, Phytochemistry, traditional and modern uses of Actaea racemosa L. (Black cohosh): A review -- Ethnobotany, phytochemistry and pharmacological features of Centella asiatica: a comprehensive review -- Ethnomedicinal uses, phytochemistry and pharmacology of different Cichorium species (Asteraceae): A review -- Medicinal species of the genus Berberis: A review of their traditional and ethnomedicinal uses, phytochemistry and pharmacology -- Protective effects of intravenous magnesium sulfate in stroke patients receiving amiodarone: A randomized controlled trial -- In silico identification of novel interactions for FABP5 (Fatty Acid-Binding Protein 5) with nutraceuticals: Possible repurposing approach.
    Abstract: Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery. There are several advantages for plant-derived therapeutics including wide availability, diverse pharmacological actions and a generally good profile of safety and tolerability. Over the recent years, there have been numerous reports from clinical studies testifying to the efficacy and safety of medicinal plants and phytochemicals in ameliorating several human diseases. A plethora of basic studies has also unravelled molecular mechanisms underlying the health benefits of herbal medicines. Nevertheless, issues such as identification of bioactive ingredients, standardization of the products and drug interactions remain to be further studied. In this book, we aim to put together several chapters on the medicinal properties and pharmacological action of medicinal plants, plant species and phytochemicals. The goal of this contributed volume is to present a comprehensive collection on most important therapeutic aspects of plant-derived natural products and their molecular mechanisms of action.
    Type of Medium: Online Resource
    Pages: X, 603 p. 814 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030648725
    Series Statement: Advances in Experimental Medicine and Biology, 1308
    URL: https://doi.org/10.1007/978-3-030-64872-5
    DOI: 10.1007/978-3-030-64872-5
    DDC: 615
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  • 25
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    Protein Instability at Interfaces During Drug Product Development : Fundamental Understanding, Evaluation, and Mitigation (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Pharmaceutical chemistry. ; Chemistry, Physical and theoretical. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Pharmaceutics. ; Theoretical Chemistry. ; Biotechnology.
    Description / Table of Contents: 1. Overview of the impact of protein interfacial instability on the development of biologic products -- 2. Protein adsorption at a gas-aqueous interface -- 3. Interfacial behaviors of proteins -- 4. Interfacial stresses during drug substance purification processes -- 5. Evaluation of interfacial stress during drug product development -- 6.Relating interfacial shear and dilatations stress-es to protein aggregation in mAbs -- 7. Analytical techniques for evaluating protein instability at interfaces -- 8. Analysis of aggregates and particles -- 9. Protein interfacial instability of mixing and lyophilization during drug product manufacturing process scale-up and tech transfer -- 10. Excipients: Characterization, purpose, and selection -- 11. Interfacial stress and proteins prepared in the solid state -- 12. Interfaces in protein drug delivery: device concern -- 13. Future perspectives. .
    Abstract: Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity. This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas. .
    Type of Medium: Online Resource
    Pages: VIII, 338 p. 58 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571771
    Series Statement: AAPS Advances in the Pharmaceutical Sciences Series, 43
    URL: https://doi.org/10.1007/978-3-030-57177-1
    DOI: 10.1007/978-3-030-57177-1
    DDC: 615
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  • 26
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    Biotechnology of Anti-diabetic Medicinal Plants (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Biotechnology. ; Metabolism, Secondary. ; Plants. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy. ; Biotechnology. ; Plant Secondary Metabolism.
    Description / Table of Contents: 1 In vitro approach and quantification of ‘puerarin and genistein’ - Valuable antidiabetic compounds from Pueraria tuberosa -- 2 In Vitro Exploitation of Medicinal Plants for Continuous Supply of Antidiabetic Bioactive Compounds -- 3 Lower plants as potential source of antidiabetic compounds: The present knowledge and future prospects -- 4 Tissue culture mediated biotechnological intervention in Centella asiatica: A potential antidiabetic plant -- 5 In Vitro Approaches for Mass-Propagation of Stevia rebaudiana -- 6 Swertia chirayita, an endangered anti-diabetic plant: trends in biotechnological interventions -- 7 In vitro propagation and biotechnological improvement strategies of plants with high-intensity sweetener and anti-diabetic activities -- 8 In Vitro Culture Techniques and Metabolite Engineering for Enhanced Anti-Diabetic Secondary Metabolite Production -- 9 Saffron: A prized herb with therapeutic potential against diabetes -- 10 New Insights to Enhance the Desired Anti-Diabetic Compounds in Medicinal and Aromatic Plants Exposed to Abiotic Stress Factors -- 11 Boosting of bioactive secondary metabolites in antidiabetic plants through elicitation: A simple technology for better future -- 12 Rhizobium rhizogenes mediated genetic transformation of antidiabetic plants -- 13 Production of anti-diabetic lignans in flax cell cultures -- 14 Artificial seed development of selected anti-diabetic plants, their storage and regeneration: Progress and prospect -- 15 Cryopreservation of Anti-diabetic plants. .
    Abstract: This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.
    Type of Medium: Online Resource
    Pages: XVI, 469 p. 70 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811635298
    URL: https://doi.org/10.1007/978-981-16-3529-8
    DOI: 10.1007/978-981-16-3529-8
    DDC: 615
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  • 27
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    Introduction to Basics of Pharmacology and Toxicology : Volume 2 : Essentials of Systemic Pharmacology : From Principles to Practice (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Medical microbiology. ; Neurosciences. ; Pharmacology. ; Pharmacy. ; Medical Microbiology. ; Neuroscience.
    Description / Table of Contents: Part 1. Autonomic Nervous System -- Chapter 1. Cholinoceptor Agonists and Anticholinesterase Agents -- Chapter 2. Cholinoceptor Antagonists -- Chapter 3. Adrenergic Agonists -- Chapter 4. Adrenergic Antagonists -- Part 2. Central and Peripheral Nervous System -- Chapter 5. Neurotransmitters and Neurotransmission. Chapter 6. Hypnotics and Sedatives -- Chapter 7. Pharmacotherapy of Seizures -- Chapter 8. General Anesthetics -- Chapter 9. Drug Therapy of Psychosis and Mania -- Chapter 10. Pharmacotherapy of Depression and Anxiety Disorders Chapter 11. Pharmacotherapy of Neurodegenerative Disorders -- Chapter 12. Opioid Agonists and Antagonists -- Chapter 13. Cognition enhancers, Psychostimulants and Psychedelic Drugs -- Chapter 14. Drug Dependence and Abuse -- Chapter 15. Local Anesthetics -- Chapter 16. Skeletal muscle relaxants. Part 3. Autacoids and Other Chemical Mediators -- Chapter 17. Histamine, Serotonin, Bradykinin, and the Ergot Alkaloids -- Chapter 18. Prostaglandins, Leukotrienes and Related Compounds -- Chapter 19. Non-Steroidal Anti-Inflammatory Medicines -- Chapter 20. Drugs Used in Rheumatoid Arthritis -- Chapter 21. Pharmacotherapy of Gout -- Chapter 22. Nitric oxide, Vasoactive Peptides and Purines -- Part 4. Cardiovascular and Renal Pharmacology -- Chapter 23. Drugs Affecting Renal Excretory Function -- Chapter 24. Antihypertensive Agents -- Chapter 25. Treatment of Ischemic Heart Disease -- Chapter 26. Drugs Used in Heart Failure -- Chapter 27. Drugs Used in Cardiac Arrhythmias -- Chapter 28. Pharmacotherapy of Shock and Drugs Used in Cardiopulmonary Resuscitation -- Chapter 29. Treatment of Pulmonary Arterial Hypertension -- Chapter 30. Antiplatelets, Anticoagulants and Fibrinolytics -- Chapter 31. Drugs Used in Dyslipidemias -- Part 5. Pulmonary Pharmacology -- Chapter 32. Treatment of Asthma and COPD -- Chapter 33. Drugs Used in Cough and Rhinitis -- Part 6 Gastrointestinal Pharmacology -- Chapter 34. Drugs Used in Acid-Peptic Disorders -- Chapter 35. Drugs Affecting Gastrointestinal Motility -- Chapter 36. Antiemetics -- Chapter 37. Drug Therapy for Constipation -- Chapter 38. Antidiarrheal Agents -- Chapter 39. Irritable Bowel Syndrome -- Chapter 40. Pharmacotherapy of Inflammatory Bowel Disease -- Chapter 41. Miscellaneous Drugs Acting on the Gastrointestinal System -- Part 7. Endocrine Pharmacology -- Chapter 42. Hypothalamic and Pituitary Hormones -- Chapter 43. Pharmacotherapy of Diabetes Mellitus -- Chapter 44. Thyroid and Antithyroid Drugs -- Chapter 45. Adrenocorticosteroids and Their Antagonists -- Chapter 46. Gonadal Hormones and Their Inhibitors -- Chapter 47. Pharmacotherapy of Obesity -- Chapter 48. Drugs Affecting Bone Mineral Homeostasis -- Part 8. Hematopoietic System -- Chapter 49. Pharmacotherapy of Iron Deficiency and Other Related Anaemias -- Chapter 50. Pharmacotherapy of Vitamin B12 and Folic Acid Deficiency -- Chapter 51. Drug-Induced Blood Dyscrasias -- Part 9. Chemotherapy of Microbial Diseases -- Chapter 52. General Principles of Antimicrobial Therapy -- Chapter 53. Sulfonamides, Quinolones and Agents For Urinary Tract Infections -- Chapter 54. Penicillins, Cephalosporins and Other β-Lactam Antibiotics -- Chapter 55. Protein Synthesis Inhibitors -- Chapter 56. Antimycobacterial Drugs -- Chapter 57. Antifungal Drugs -- Chapter 58. Antiviral Drugs -- Chapter 59. Miscellaneous Antimicrobial Agents -- Chapter 60. Chemotherapy of Malaria and Other Protozoal Diseases -- Chapter 61. Chemotherapy of Helminthiasis -- Part 10. Pharmacotherapy of Neoplastic Disease -- Chapter 62. General Principles of Cancer Chemotherapy -- Chapter 63. Cytotoxic Drugs -- Chapter 64. Targeted Chemotherapy -- Chapter 65. Hormones Agents in the Pharmacotherapy of Cancer -- Chapter 66. Immunopharmacology -- Chapter 67. Dermatological Pharmacology -- Chapter 68. Ocular Pharmacology -- Chapter 69. Nutritional Supplements and Herbal Medicines -- Chapter 70. Immunoglobulins and Vaccines. .
    Abstract: This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. .
    Type of Medium: Online Resource
    Pages: XXIV, 1175 p. 152 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360099
    URL: https://doi.org/10.1007/978-981-33-6009-9
    DOI: 10.1007/978-981-33-6009-9
    DDC: 615
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    The 'Big Four’ Snakes of India : Venom Composition, Pharmacological Properties and Treatment of Envenomation (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Invertebrates. ; Medicine Research. ; Biology Research. ; Epidemiology. ; Biochemistry. ; Pharmacology. ; Invertebrate Zoology. ; Biomedical Research. ; Epidemiology. ; Biochemistry.
    Description / Table of Contents: Chapter 1. Introduction: The snakebite problem -- Chapter 2. Evolution of snakes and systematics of Big Four venomous snakes of India -- Chapter 3. Snake venom: Composition, evolution, function, and biomedical applications -- Chapter 4. Indian spectacled cobra (Naja naja) -- Chapter 5. Indian common Krait (Bungarus cerelus) -- Chapter 6. Indian Russell’s viper (Daboia russelii) -- Chapter 7. Indian Saw-scaled viper (Echis carinatus) -- Chapter 8. Prevention and Treatment of Big Four Snakebite in India.
    Abstract: This book provides detailed and updated knowledge about medically important ‘Big Four’ venomous snakes of India (Indian spectacled cobra, Indian common krait, Indian Russell’s viper, and Indian saw-scaled viper). This book essentially covers the snakebite problem in the world with particular reference to Asia and India. It discusses the evolution and systematics of venomous snakes, emphasizing ‘Big Four’ venomous snakes of India; the evolution and composition of venoms determined by traditional biochemical and modern proteomic analyses. It also describes the pharmacological properties of enzymatic and non-enzymatic toxins of ‘Big Four’ venomous snakes of India. Different chapters discuss exciting topics such as species-specific and geographical differences in venom composition and its impact on pathophysiology and clinical manifestations of snakebite envenomation in India, biomedical application of Indian snake venom toxins; production and quality assessment of commercial antivenom, prevention, and treatment of snakebite in India, adverse effects of antivenom including strategies to combat antivenom reactions inpatient. This book caters to toxinologists, pharmacologists, zoologists, antivenom manufacturers, biochemists, clinicians, evolutionary biologists, herpetologists, and informed non-specialists interested to know about the Indian snake venoms. .
    Type of Medium: Online Resource
    Pages: XI, 161 p. 55 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811628962
    URL: https://doi.org/10.1007/978-981-16-2896-2
    DOI: 10.1007/978-981-16-2896-2
    DDC: 615
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    Viral Vectors in Veterinary Vaccine Development : A Textbook (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Veterinary microbiology. ; Virology. ; Pharmacology. ; Veterinary Microbiology. ; Virology.
    Description / Table of Contents: Chapter 1. Introduction to Veterinary Vaccines -- Chapter 2. "What is Required to Develop a Viral Vector Vaccine: Key Components of Vaccine-Induced Immune Responses" -- Chapter 3. Viruses and the evolution of viral vectors -- Chapter 4. The role of adjuvants in the application of viral vector vaccines -- Chapter 5. Adenovirus Vectors -- Chapter 6. Poxvirus Vectors -- Chapter 7. The Construction and Evaluation of Herpesvirus Vectors -- Chapter 8. Paramyxoviruses as Vaccine Vectors -- Chapter 9. Rhabdoviruses as vaccine vectors for veterinary pathogens -- Chapter 10. Coronaviruses as Vaccine Vector for Veterinary Pathogens -- Chapter 11. Alphavirus-Based Vaccines -- Chapter 12. Manufacturing and Control of Viral Vectored Vaccines: Challenges -- Chapter 13. Regulatory strategies and factors affecting veterinary viral vector development -- Chapter 14. "Emerging Viral Vectored Technology Future potential of capripoxvirus and African swine fever virus as viral vectors". .
    Abstract: This highly accessible textbook introduces readers to the development of viral vectors and discusses their application in veterinary vaccinology. It offers comprehensive information on the latest advances in this emerging research field, together with a broad overview of the history of veterinary vaccines and viral vectors. The book also addresses issues concerning funding, translational research and ethics that will impact the future development, manufacture and global use of viral vector-based veterinary vaccines. The book addresses the needs of graduate students and researchers in the fields of Veterinary Medicine, Virology and Immunology. .
    Type of Medium: Online Resource
    Pages: XI, 230 p. 35 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030519278
    URL: https://doi.org/10.1007/978-3-030-51927-8
    DOI: 10.1007/978-3-030-51927-8
    DDC: 615
    Language: English
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    Online Resource
    Protein Kinase-mediated Decisions Between Life and Death (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacology.
    Description / Table of Contents: Protein kinase-mediated decision between life and death -- Aging, cellular senescence and protein kinases -- Oxidative stress-related endothelial cell death and protein kinases -- Signal transduction in immune cells and protein kinases -- Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity -- Metabolic stress and immunity -- Activation of tropomyosin-related kinase receptor B by N-acetyl-serotonin: implications for neuroprotection -- Protein kinase inhibitors in traumatic brain injury and repair -- Amyloid beta toxicity in Alzheimer’s Disease and neuronal death-associated protein kinases -- Glucolipotoxicity-related beta cell death and protein kinases -- Protein kinases and cell death in hematological disorders -- A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy -- Bile acid toxicity and protein kinases -- Nanoparticle toxicity: Protein kinases and cell death -- Two-component signal transduction systems in antibiotic resistance -- ERK1/2 MAP kinase, its regulation and role in cellular activities including apoptosis and cell survival. .
    Abstract: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 415 p. 30 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030498443
    Series Statement: Advances in Experimental Medicine and Biology, 1275
    URL: https://doi.org/10.1007/978-3-030-49844-3
    DOI: 10.1007/978-3-030-49844-3
    DDC: 615
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    Online Resource
    Drug Discovery and Drug Development : The Indian Narrative (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Drug delivery systems. ; Biologicals. ; Biopharmaceutics. ; Toxicology. ; Biotechnology. ; Pharmacology. ; Drug Delivery. ; Biologics. ; Toxicology. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Traditional Medical System (TMS) for Sustainable Healthcare in India -- Chapter 2. Modern Drug Discovery and Development for TB- The India Narrative -- Chapter 3. Indian Discovery Effort in the Quest of Novel Antibiotics -- Chapter 4. New Drug Discovery and Development in India to Counter Malaria -- Chapter 5. Modern Drug Discovery and Development in the area of Leishmaniasis -- Chapter 6. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part I – Introduction to Diabetes and Prevalence in India -- Chapter 7. Modern Drug Discovery and Development: Diabetes and lifestyle disorder Part II Type 2 Diabetes Mellitus: Marketed drugs and mechanisms -- Chapter 8. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part III Anti-diabetes research in India: Contributions from industrial organizations -- Chapter 9. Modern Drug Discovery and Development: Diabetes and lifestyle disorders Part IV Indian Academia Tryst with Cardio-metabolic Drug Discovery and Development -- Chapter 10. Modern drug discovery and development in the area of Cancer: Indian context -- Chapter 11. Biopharmaceutical development in India: recommendations on collaboration and innovation to enable affordable healthcare -- Chapter 12. Regulatory requirements and Quality Standards in India’s Clinical Trials Journey -- Chapter 13. Indian Pharma Perspective: New Drug Discovery and Development- Indian Pharmaceutical Industry.
    Abstract: Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India’s New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR. .
    Type of Medium: Online Resource
    Pages: XIII, 376 p. 191 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811580024
    URL: https://doi.org/10.1007/978-981-15-8002-4
    DOI: 10.1007/978-981-15-8002-4
    DDC: 615
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  • 32
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    Online Resource
    Gold and its Complexes in Anticancer Chemotherapy (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicinal chemistry. ; Cancer. ; Microtechnology. ; Microelectromechanical systems. ; Pharmacovigilance. ; Pharmacology. ; Medicinal Chemistry. ; Cancer Biology. ; Microsystems and MEMS. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: Chapter 1. Cancer -- Chapter 2. Types of cancer -- Chapter 3. Classification -- Chapter 4. Cancer or tumor nomenclature -- Chapter 5. Heterogeneity -- Chapter 6. Invasion and metastasis -- Chapter 7. How cancer arises? -- Chapter 8. Epidemiology -- Chapter 9. Economic burden -- Chapter 10. Treatment modalities -- Chapter 11. Chemotherapy -- Chapter 12. Properties of metals and metal complexes -- Chapter 13. Platinum based anticancer agents -- Chapter 14. Chemistry of cisplatin -- Chapter 15. Mechanism of action of platinum drugs -- Chapter 16. Non-platinum anticancer agents -- Chapter 17. Chemistry of gold -- Chapter 18. Gold and its complexes in medicine -- Chapter 19. Auranofin and its analogues -- Chapter 20. Classes of gold complexes -- Chapter 21. Mechanisms of action of anticancer gold complexes -- Chapter 22. Perspectives.
    Abstract: This book presents an overview of cancer and the genesis, and development of different treatment strategies and modalities against cancer. The emergence of gold and its complexes as promising anticancer chemotherapeutic agents have the potential to substitute or replace the platinum based chemotherapeutic agents. Gold complexes have demonstrated considerable anti-proliferative properties, chiefly attributed to their anti-mitochondrial effects, they make gold complexes excellent candidates as anti-cancer agents compared to their platinum-based counterparts. This book provides a critical review of recent advances made in the development of gold complexes as anti-cancer agents. In this context, it examines a number of different ligand architectures, provides comprehensive information on gold complexes’ mechanism of action and toxicity issues and, in closing, outlines future research directions.
    Type of Medium: Online Resource
    Pages: IX, 173 p. 124 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813363144
    URL: https://doi.org/10.1007/978-981-33-6314-4
    DOI: 10.1007/978-981-33-6314-4
    DDC: 615
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    Online Resource
    Molecularly Imprinted Polymers as Advanced Drug Delivery Systems : Synthesis, Character and Application (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Drug delivery systems. ; Biotechnology. ; Pharmacology. ; Drug Delivery. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Synthetic Strategies for the Generation of Molecularly Imprinted Polymers -- Chapter 3. Special Control by Molecular Imprinting Materials-zero-order Sustained Release, Enantioselective MIPs and Self-regulated Drug Delivery Microdevices -- Chapter 4. Water Compatible Molecularly Imprinted Polymers -- Chapter 5. Stimuli Responsive Imprinted DDS -- Chapter 6. MIP as Drug Delivery Systems for Dermal Delivery -- Chapter 7. MIP as Drug Delivery Systems of Anticancer Agents -- Chapter 8. MIP as Dug Delivery Systems of Ophthalmic Drugs -- Chapter 9. MIP as Drug Delivery Systems for Special Application -- Chapter 10. Outlook.
    Abstract: This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives.
    Type of Medium: Online Resource
    Pages: VII, 216 p. 108 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602276
    URL: https://doi.org/10.1007/978-981-16-0227-6
    DOI: 10.1007/978-981-16-0227-6
    DDC: 615
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    Novel Drug Delivery Systems for Chinese Medicines (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Alternative medicine. ; Pharmacy. ; Pharmacology. ; Complementary and Alternative Medicine. ; Pharmacy.
    Abstract: This book describes the essential and cutting-edge concepts based on the frontier of pharmaceutical research in TCM, underlying scientific principles, and current advancements of drug delivery systems for Chinese medicines, including sustained-release drug delivery systems, trans-nasal drug delivery systems, dermal and transdermal drug delivery systems, etc. Novel carriers and emerging technologies (such as 3D printing) are also covered. The book provides readers with an overall picture of drug delivery systems for Chinese medicines and also yields benefits for the pharmaceutical industry with regard to TCM-based drug development.
    Type of Medium: Online Resource
    Pages: XIII, 336 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811634444
    URL: https://doi.org/10.1007/978-981-16-3444-4
    DOI: 10.1007/978-981-16-3444-4
    DDC: 615
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    Nanoparticles for Rational Vaccine Design (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Nanochemistry. ; Virology. ; Pharmacology. ; Human Physiology. ; Nanochemistry. ; Virology.
    Description / Table of Contents: Preface -- Liposome Formulations as Adjuvants for Vaccines -- Polymeric nanoparticle-based vaccine adjuvants and delivery vehicles -- Virus-like particle vaccines against respiratory viruses and protozoan parasites -- Protein and Peptide Nanocluster Vaccines.
    Abstract: This book introduces nanoparticles as a powerful platform for vaccine design. Current challenges in vaccine development are discussed and the unique advantages nanoparticles provide in overcoming these challenges are explored. The authors offer fascinating insights into the immunological assets of using nanoparticles as delivery vehicles or adjuvants and present different materials that are being used in nanoparticle-based vaccine development, covering peptides, proteins, polymers, virus-like particles, and liposomes. Its contemporary research insights and practical examples for applications make this volume an inspiring read for researchers and clinicians in vaccinology and immunology. Chapter "Liposome Formulations as Adjuvants for Vaccines" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VII, 130 p. 26 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030850678
    Series Statement: Current Topics in Microbiology and Immunology, 433
    URL: https://doi.org/10.1007/978-3-030-85067-8
    DOI: 10.1007/978-3-030-85067-8
    DDC: 615
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  • 36
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    Landscapes and Landforms of Scotland (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Earth sciences. ; Geography. ; Physical Geography. ; Earth Sciences. ; Regional Geography.
    Description / Table of Contents: Landscapes and Landforms of Scotland: a Geomorphological Odyssey -- Part I Physical Environment: Scotland: Geological Foundations and Landscape Evolution -- Long-term Denudation and Geomorphology in Scotland -- The Quaternary in Scotland -- Scotland’s Changing Landscape -- Part II Landscapes and Landforms: Geomorphology of the Continental Shelf -- Shetland -- Orkney and Caithness -- The Outer Hebrides and St Kilda -- The Islands of the Hebridean Igneous Province: Skye, Mull, Rùm and Arran -- The Islands of Islay, Jura, Colonsay, Tiree and Coll -- The Far Northwest: Sutherland, Assynt and Coigach -- Wester Ross -- Rock-slope Failures in the North West Highlands -- The Glacial Geomorphology around Inverness and the Great Glen -- Glen Roy and Glen Spean -- Western Grampian Highlands -- The Cairngorm Mountains -- Fluvial Landforms of Glen Feshie and the Spey Drainage Basin -- Central and Eastern Grampian Highlands -- The Buchan Palaeosurface -- Beaches and Dunes of the Moray Firth Coast -- Beaches and Dunes of Eastern Scotland -- Loch Lomond, Menteith and the Forth Valley -- Glacifluvial and Glacilacustrine Landforms of the Midland Valley -- The Midland Valley: Ice-moulded Lowlands -- Upland Landscapes and Landforms of the Southern Uplands -- The Solway Lowlands and Coast -- Part III Geoheritage, Scotland's Geomorphological Heritage and its Conservation -- Index.
    Abstract: This book provides an appealing and informative overview of the outstanding landforms and landscapes of Scotland. Scotland is internationally renowned for the diversity of its geology, landforms and landscapes. The rock record spans most of geological time, from the Archaean to the Palaeogene, and represents the outcome of tectonic plate movements, associated geological processes, and sea-level and climate changes. Scotland incorporates primeval gneiss landscapes, the deeply eroded roots of the Caledonian mountain chain, landscapes of extensional tectonics and rifting, and eroded remnants of volcanic complexes that were active when the North Atlantic Ocean opened during the Palaeogene. The present relief reflects uplift and deep weathering during the Cenozoic, strongly modified during successive episodes of Pleistocene glaciation. This striking geodiversity is captured in this book through 29 chapters devoted to the evolution of Scotland’s scenery and locations of outstanding geomorphological significance, including ancient palaeosurfaces, landscapes of glacial erosion and deposition, evidence of postglacial landscape modification by landslides, rivers and wind, and coastal geomorphology. Dedicated chapters focus on Ice Age Scotland and the associated landscapes, which range from alpine-type mountains and areas of selective glacial erosion to ice-moulded and drift-covered lowlands, and incorporate accounts of internationally renowned sites such as the ‘Parallel Roads’ of Glen Roy, the Cairngorm Mountains and the inselbergs of Assynt. Other chapters consider the record of postglacial rock-slope failures, such as the famous landslides of Trotternish on Skye, and the record of fluvial changes since deglaciation. The sea-level history of Scotland is addressed in terms of its raised and submerged shorelines, while several chapters discuss the contrasting coastal landscapes, which range from the spectacular sea cliffs of Shetland and Orkney to the beaches and dunes of eastern Scotland. The role of geoconservation in preserving Scotland’s outstanding geomorphological heritage is outlined in the final chapter. The book offers an up-to-date and richly illustrated reference guide for geomorphologists, other Earth scientists, geographers, conservationists, and all those interested in geology, physical geography, geomorphology, geotourism, geoheritage and environmental protection. .
    Type of Medium: Online Resource
    Pages: XIV, 503 p. 273 illus., 242 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030712464
    Series Statement: World Geomorphological Landscapes,
    URL: https://doi.org/10.1007/978-3-030-71246-4
    DOI: 10.1007/978-3-030-71246-4
    DDC: 910.02
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    Arctic Hydrology, Permafrost and Ecosystems (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Water. ; Hydrology. ; Climatology. ; Environmental monitoring. ; Engineering geology. ; Physical Geography. ; Water. ; Climate Sciences. ; Environmental Monitoring. ; Geoengineering. ; Earth System Sciences.
    Description / Table of Contents: Introduction -- Hydrology -- Permafrost and seasonal frozen ground -- Ecosystems -- Linkage and integration.
    Abstract: This book provides a comprehensive, up-to-date assessment of the key terrestrial components of the Arctic system, i.e., its hydrology, permafrost, and ecology, drawing on the latest research results from across the circumpolar regions. The Arctic is an integrated system, the elements of which are closely linked by the atmosphere, ocean, and land. Using an integrated system approach, the book’s 30 chapters, written by a diverse team of leading scholars, carefully examine Arctic climate variability/change, large river hydrology, lakes and wetlands, snow cover and ice processes, permafrost characteristics, vegetation/landscape changes, and the future trajectory of Arctic system evolution. The discussions cover the fundamental features of and processes in the Arctic system, with a special focus on critical knowledge gaps, i.e., the interactions and feedbacks between water, permafrost, and ecosystem, such as snow pack and permafrost changes and their impacts on basin hydrology and ecology, river flow, geochemistry, and energy fluxes to the Arctic Ocean, and the structure and function of the Arctic ecosystem in response to past/future changes in climate, hydrology, and permafrost conditions. Given its scope, the book offers a valuable resource for researchers, graduate students, environmentalists, managers, and administrators who are concerned with the northern environment and resources.
    Type of Medium: Online Resource
    Pages: XII, 914 p. 397 illus., 335 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030509309
    URL: https://doi.org/10.1007/978-3-030-50930-9
    DOI: 10.1007/978-3-030-50930-9
    DDC: 910.02
    Language: English
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    Watershed Erosion Processes (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Earth sciences. ; Soil science. ; Environment. ; Geographic information systems. ; Physical Geography. ; Earth Sciences. ; Soil Science. ; Environmental Sciences. ; Geographical Information System. ; Earth Sciences.
    Description / Table of Contents: Chapter1: Introduction -- Chapter2: Watershed climatic, physiographic and anthropogenic conditions -- Chapter3: Rainwash erosion -- Chapter4: Gully erosion -- Chapter5: Mass movements -- Chapter6: Tunnel erosion -- Chapter7: Spatial interactions of different erosion processes -- Chapter8: Watershed sediment budget -- Chapter9: Comprehensive soil conservation within the watershed -- Chapter10: Watershed modelling and its applications -- Chapter11: Conclusions.
    Abstract: This monograph is a fundamental study of watershed erosion and runoff processes. It utilizes decades of soil erosion data to take a comprehensive and balanced approach in covering various watershed erosion processes. While there are many works on soil erosion and conservation, this book fills the gaps in previously published research by focusing more on mass movement, gully erosion, soil piping/tunnel erosion, and the spatial interactions of different erosion processes. Additionally, the book examines erosion processes in extreme rainfall events, something typically absent in short-term studies but discussed in detail here as the book draws on 60 years of research and observations, including 30 years of the author's own investigations of erosion under a wide range of rainfall conditions. The book is divided into 3 parts, and is intended for soil erosion researchers and practitioners, and postgraduate students studying soil erosion and water conservation. Part 1 opens with a comprehensive and critical review of existing literature on soil erosion processes, discusses this book's place among existing literature, and examines the major erosion processes (rainwash, gully erosion, tunnel erosion, and mass movements) including their controlling factors and mechanisms. Part 2 explores the spatial interactions of these different erosion processes to provide a prerequisite for effective design of comprehensive soil erosion control measures in a watershed. Part 3 evaluates the relative significance of these erosion processes in sediment production, the effectiveness of comprehensive soil and water conservation programs, and the applications of watershed modelling in determining the impact of land-use changes on soil erosion and other ecological processes.
    Type of Medium: Online Resource
    Pages: IX, 172 p. 121 illus., 98 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030811518
    Series Statement: Geography of the Physical Environment,
    URL: https://doi.org/10.1007/978-3-030-81151-8
    DOI: 10.1007/978-3-030-81151-8
    DDC: 910.02
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    Online Resource
    The Nile Waters : Weighed from Space (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Water. ; Hydrology. ; Environmental management. ; International relations. ; Physical Geography. ; Water. ; Environmental Management. ; International Relations.
    Description / Table of Contents: Water Resources -- The White Nile -- Background of the White Nile -- Resources of the White Nile -- Eco-Tourism in the White Nile -- Economic Development in the White Nile -- Wetlands of the White Nile -- Part II The Blue Nile -- Background of the Blue Nile -- Resources of the Blue Nile -- Eco-Tourism in the Blue Nile -- Economic Development in the Blue Nile -- Wetlands of the Blue Nile -- Meeting the Challenges -- Environmental Challenges -- Economic Challenges -- Poverty Challenges -- Management Challenges -- Past and Current Initiatives -- Meeting the Challenges.
    Abstract: This book is useful to those in water resources management and policy formulations, hydrologists, environmentalists, engineers and researchers. Exploiting advanced statistical techniques and the latest state-of-the-art multi-mission satellites, surface models and reanalysis products, this book provides the first comprehensive weighing of the changes in the Nile River Basin’s (NRB: ~ 3,400,000 km2 ) stored waters' compartments, surface, soil moisture and groundwater, and their association to climate variability/change and anthropogenic impacts on the one hand. On the other hand, it argues on the need for equitable use of the NRB’s waters by all 11 countries within its basin, and doing away with obsolete Nile treaties that were signed by Britain, Egypt and Sudan, which prohibit the use of the Nile by 8 upstream countries. With Ethiopia’s construction of Africa’s largest dam (GERD; Grand Ethiopian Renaissance Dam) along the Blue Nile, which is expected to take several years to fill, the Nile is back on the news. Combined with Uganda’s Nalubaale, Kiira and Bujagali dams on the White Nile, these human-induced impacts (i.e., damming), coupled with those of climate variability/change, are expected to exacerbate tension with the low stream countries (Egypt and Sudan) fearing the cut in theNile’s total volume. Furthermore, the Nile river, arguably the world’s longest river (6800 km), impacts on the livelihood of over 300 million people of 11 countries within its basin. This population is expected to double in the next twenty-five years, thereby putting extreme pressure on its water resources. An in-depth analysis of changes in the Nile’s stored waters, therefore, is essential to inform its management and sustainable equitable use. Owing to its sheer size, however, obtaining in-situ data from “boots on the ground” is practically impossible, paving way to the space-based weighing of the Nile River Basin using a suite of high spatio-temporal remotely sensed and reanalysis products, as well as those of hydrological models. “Arguably, the Nile River is the most unique river in the world. It spans extremes of rainfall from being measured by meters to being measured by centimeters, from the humid tropics to the driest of deserts. Yet, thirsty people live throughout this basin and therefore the demands on its water resources are uneven. Knowing the water amounts throughout the entire Nile Basin is a critical step for governments and international treaties to avoid the “Tragedy of the Commons”. Africa can embrace this future through the leadership of Prof. Awange and others like him who have devoted their careers to Africa’s waters” —Doug Alsdorf, Ph.D., Professor of Geophysics at the Ohio State University. .
    Type of Medium: Online Resource
    Pages: XVII, 267 p. 92 illus., 88 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030647568
    URL: https://doi.org/10.1007/978-3-030-64756-8
    DOI: 10.1007/978-3-030-64756-8
    DDC: 910.02
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    Coronary Artery Disease: Therapeutics and Drug Discovery (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Description / Table of Contents: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Abstract: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Type of Medium: Online Resource
    Pages: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811525179
    Series Statement: Advances in Experimental Medicine and Biology, 1177
    URL: https://doi.org/10.1007/978-981-15-2517-9
    DOI: 10.1007/978-981-15-2517-9
    DDC: 615
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    Pediatric Pharmacotherapy (2020)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.
    Abstract: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
    Type of Medium: Online Resource
    Pages: VIII, 538 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504946
    Series Statement: Handbook of Experimental Pharmacology, 261
    URL: https://doi.org/10.1007/978-3-030-50494-6
    DOI: 10.1007/978-3-030-50494-6
    DDC: 615
    Language: English
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    Vaccination Strategies Against Highly Variable Pathogens (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human physiology. ; Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human Physiology.
    Description / Table of Contents: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.
    Abstract: Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. .
    Type of Medium: Online Resource
    Pages: VII, 180 p. 16 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030580049
    Series Statement: Current Topics in Microbiology and Immunology, 428
    URL: https://doi.org/10.1007/978-3-030-58004-9
    DOI: 10.1007/978-3-030-58004-9
    DDC: 615
    Language: English
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    Online Resource
    Drug Stability and Chemical Kinetics (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.
    Description / Table of Contents: 1 Principles of pharmaceutical analysis in drug stability and chemical kinetics -- 2 Guidelines for drug stability and stability testing -- 3 Chemical kinetics and its applications in drug stability -- 4 Methods and protocols for drug stability studies -- 5 Physical basis of degradation of pharmaceutical products -- 6 Role of microbiological degradation on drug stability -- 7 Role of decomposition on drug stability -- 8 Role of catalysis in drug stability -- 9 Analytical techniques for the assessment of drug stability -- 10 Stability of pharmaceutical products -- 11 Role of kinetic models in drug stability -- 12 Stability studies of vaccines -- 13 Stability studies of proteinous compounds -- 14 Stability studies of extemporaneous pharmaceutical products -- 15 Stability studies of parenteral products -- 16 Stability studies of solid dosage forms.
    Abstract: This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .
    Type of Medium: Online Resource
    Pages: XIV, 284 p. 22 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564260
    URL: https://doi.org/10.1007/978-981-15-6426-0
    DOI: 10.1007/978-981-15-6426-0
    DDC: 615
    Language: English
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  • 44
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    Online Resource
    Handbook of 200 Medicinal Plants : A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Medicinal chemistry. ; Pharmacology. ; Pharmacy. ; Medicinal Chemistry.
    Description / Table of Contents: Abelmoschus maschatus -- Abrus precatorius -- Abutilon indicum -- Acacia catechu -- Acacia nilotica (A. arabica) -- Achillea millefolium -- Achyranthes aspera -- Aconitum napellus -- Acorus calamus -- Adiantum venustum (Adiantun capillus-veneris) -- Aegle marmelos -- Agrimonia eupatorium.-Alhagi maurorum -- Alkanna tinctoria -- Allium cepa -- Allium sativum -- Aloe vera -- Alpinia galangal -- Alpinia officinarum -- Alstonia scholaris -- Althaea officinalis -- Ammi majus -- Anacardium occidentale -- Anacyclus pyrethrum -- Andrographis paniculata -- Anethum graveolens -- Anthemis nobilis -- Apium graveolens -- Argemone Mexicana -- Aristolochia bracteolata -- Aristolochia fontanesii (A. longa) -- Aristolochia indica -- Aristolochia rotunda -- Artemisia absinthium -- Artemisia vulgaris -- Asparagus adscendens -- Asparagus officinalis -- Asparagus racemosus -- Atropa belladonna -- Azadirachta indica -- Bacopa monnieri -- Bauhinia tomentosa -- Berberis Aristata -- Berberis vulgaris -- Bombyx mori -- Borago officinalis -- Boswellia serrata -- Brassica nigra -- Butea monosperma -- Caccinia macranthera var. glauca (C. glauca) -- Caesalpinia bonduc (Caesalpinia bonducella) -- Cannabis sativa -- Capparis spinosa -- Cardiospermum halicacabum -- Carthamus tinctorius -- Carum carvi -- Cassia fistula -- Catharanthus roseus -- Celastrus paniculatus -- Centaurea behen -- Centella asiatica -- Chamaecrista absus (Cassia absus) -- Chamaemelum nobile (Anthemis nobilis) -- Cheilocostus speciosus (Costus Speciosus) -- Cichorium intybus -- Cinnamomum camphora -- Cinnamomum cassia -- Cinnamomum verum (C. zeylanicum) -- Citrullus colocynthis -- Clitoria ternatea -- Colchicum autumnale -- Colchicum luteum -- Commiphora gileadensis (C. opobalsamum) -- Commiphora myrrha -- Commiphora wightii (C. mukul) -- Convolvulus scammonia -- Cotoneaster nummularius -- Crocus sativus -- Croton tiglium -- Cullen corylifolium (Psoralea corylifolia) -- Cuminum cyminum -- Curcuma aromatica -- Curcuma longa -- Curcuma zedoaria -- Cuscuta chinensis -- Cuscuta reflexa -- Cydonia oblonga -- Cymbopogon schoenanthus -- Cyperus rotundus -- Datura stramonium -- Delphinium denudatum -- Dolichousnea longissimi (Usnea longissima) -- Doronicum pardalianches -- Embelia ribes -- Euphorbia hirta -- Euphorbia resinifera -- Ferula assa-foetida -- Ficus carica -- Ficus racemosa -- Foeniculum vulgare -- Fumaria officinalis -- Gentiana lutea -- Glycyrrhiza glabra -- Gymnema sylvestre -- Helleborus niger -- Hemidesmus Indicus -- Hibiscus rosa-sinensis -- Holarrhena pubescens (Holarrhena antidysenterica) -- Hyoscyamus niger -- Hyssopus officinalis -- Illicium verum -- Iris germanica -- Juniperus communi -- Justicia adhatoda (Adhatoda vasica) -- Lactuca sativa -- Lavandula stoechas -- Lawsonia inermis -- Lepidium sativum -- Linum usitatissimum -- Lupinus albus -- Malva sylvestris -- Marrubium vulgare -- Matricaria chamomilla -- Melia azedarach -- Melilotus officinalis -- Melissa officinalis -- Mesua ferrea -- Momordica charantia -- Moringa oleifera -- Myristica fragrans -- Myrtus communis -- Nageia nagi -- Nepeta cataria -- Nigella sativa -- Ocimum basilicum -- Ocimum gratissimum -- Ocimum tenuiflorum (Ocimum sanctum -- Operculina turpethum -- Paeonia emodi -- Pandanus odorifer (Pandanus Odoratissimus) -- Papaver somniferum -- Persicaria bistorta -- Phyllanthus emblica (Emblica officinalis) -- Picrorhiza kurroa -- Pimpinella anisum -- Piper cubeba -- Piper nigrum -- Pistacia lentiscus -- Plantago major -- Plantago ovata -- Plumbago zeylanica -- Polygonum aviculare -- Portulaca oleracea -- Quercus infectoria -- Rauvolfia serpentina -- Rheum emodi -- Rheum officinale -- Ricinus communis -- Rubia cordifolia -- Rumex vesicarius -- Ruta graveolens -- Salix caprea -- Salvia officinalis -- Santalum album -- Saussurea lappa -- Semecarpus anacardium -- Senna alexandrina -- Senna occidentalis -- Senna tora -- Sida cordifolia -- Smilax china;- Solanum americanum (S. nigrum) -- Sterculia urens -- Strychnos nux-vomica -- Swertia chirata -- Symplocos racemosa -- Syzygium cumini (Eugenia jambolana) -- Tamarindus indica -- Taraxacum officinale -- Taxus baccata -- Tephrosia purpurea -- Terminalia bellirica -- Terminalia chebula -- Thymus vulgaris -- Tinospora cordifolia -- Trachyspermum ammi (Ptychotis coptica) -- Tribulus terrestris -- Trigonella foenum-graecum -- Tussilago farfara -- Valeriana jatamansi (Nardostachys jatamansi) -- Verbena officinalis -- Vernonia anthelmintica (Baccharoides anthelmintica) -- Vigna unguiculata (Dolichos biflorus) -- Viola odorata -- Viscum album -- Withania somnifera -- Wrightia tinctoria -- Zingiber officinale -- Zingiber zerumbet -- Ziziphus jujuba -- Abbreviations -- Glossary -- Ayurvedic Terms of Diseases -- List of Referenced Books -- Index.
    Abstract: This book is designed to provide pharmacologists and researchers of natural products a comprehensive review of 200 medicinal plants, their vernacular names in various languages and their medicinal uses around the world, and in some cases, a historical perspective. Chemical constituents of each plant with the putative active constituent, and available up to date pharmacological studies (until 2017 on PubMed) with each medical activity explored and its relationship with traditional uses, are described for each plant. Any variations in chemical constituents and their effects on pharmacological studies outcome have been highlighted. All clinical trials conducted, with sufficient details, have been included. Nationalities and racial identities of participants of clinical trials are identified to impress upon the social, cultural and dietary influences on the clinical outcomes. Toxicity studies and potential interactions with prescribed drugs, and full spectrum of references are included.
    Type of Medium: Online Resource
    Pages: XXX, 2156 p. 199 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030168070
    URL: https://doi.org/10.1007/978-3-030-16807-0
    DOI: 10.1007/978-3-030-16807-0
    DDC: 615
    Language: English
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    Approaching Complex Diseases : Network-Based Pharmacology and Systems Approach in Bio-Medicine (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Bioinformatics. ; Oncology. ; Medicine Philosophy. ; Pharmacology. ; Computational and Systems Biology. ; Oncology. ; Philosophy of Medicine.
    Description / Table of Contents: Chapter 1. Revisiting the concept of human disease (Mariano Bizzarri, Mirko Minini, and Noemi Monti) -- Chapter 2. Dynamical aspects of pharmacokinetic/pharmacodynamics and quantitative systems pharmacology models (Ioannis Loisios-Konstantinidis, Panteleimon D. Mavroudis, Panos Macheras) -- Chapter 3. The efficiency of multi-target drugs: a network approach (Lucas N. Alberca, Alan Talevi) -- Chapter 4. Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases (Vinicius M. Alvesa, Stephen J. Capuzzia, Nancy Baker, Eugene N. Muratov, Alexander Trospsha, and Anthony J. Hickey) -- Chapter 5. Big Data, Personalized Medicine and Network Pharmacology: beyond the current paradigms (Alessandro Giuliani and Virginia Todde) -- Chapter 6. Epigenetic Control Using Small Molecules in Cancer (Tomohiro Kozako, Yukihiro Itoh, Shinichiro Honda, Takayoshi Suzuki) -- Chapter 7. Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread (Mark AJ Chaplain) -- Chapter 8. Precision Oncology vs Phenotypic approaches in the management of cancer: a case for the postmitotic state (Armando Aranda-Anzaldo and Myrna A.R. Dent) -- Chapter 9. Migrastatics - anti-metastatic drugs targeting cancer cell invasion (Aneta Gandalovičová , Daniel Rosel , Jan Brábek) -- Chapter 10. Critical steps in Epithelial-Mesenchymal transition as target for cancer treatment (Evgeny V. Denisov, Mohit Kumar Jolly, Vitaly P. Shubin, Alexey S. Tsukanov, Nadezhda V. Cherdyntseva) -- Chapter 11. Targeting the tumor-associated macrophages for ‘normalizing’ cancer (Julia Kzhyshkowska) -- Chapter 12. Tumor Reversion induced by embryo and oocyte extracts (Sara Proietti, Andrea Pensotti and Alessandra Cucina) -- Chapter 13. Trabectedin, a drug acting on both cancer cells and the tumor microenvironment (Paola Allavena, Manuela Liguori, Cristina Belgiovine) -- Chapter 14. Advances in Characterizing Recently-identified Molecular Actions of Melatonin: Clinical Implications (Russel J. Reiter, Ramaswamy Sharma, Sergio A. Rosales-Corral, Ana Coto-Montes, Jose Antonio Boga, Jerry Vriend) -- Chapter 15. Multitarget activities of Inositol and Inositol Hexakisphosphate (Ivana Vucenik) -- Chapter 16. Integration of Phytochemicals and Phytotherapy into Cancer Precision Medicine (Nadire Özenver and Thomas Efferth) -- Chapter 17. Synergistic Effects of Chinese Herbal Medicine and Biological Networks (Deep Jyoti Bhuyan, Saumya Perera1, Kirandeep Kaur, Muhammad A. Alsherbiny, Mitchell Low, Sai-Wang Seto, Chun-Guang Li, Xian Zhou) -- Chapter 18. Medicinal herbs: its therapeutic use in obstetrics and gynaecology (Irene Orbe, Daniel Paz, Leyre Pejenaute, Andrea Puente, Laura Diaz de Alda, Sandra Yague, Iñaki Lete) -- Chapter 19. Overcoming Antibiotic Resistance: New Perspectives (Matteo Bassetti, Elda Righi).
    Abstract: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
    Type of Medium: Online Resource
    Pages: XVI, 483 p. 49 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030328573
    Series Statement: Human Perspectives in Health Sciences and Technology, 2
    URL: https://doi.org/10.1007/978-3-030-32857-3
    DOI: 10.1007/978-3-030-32857-3
    DDC: 615
    Language: English
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    Pharmacology of Immunotherapeutic Drugs (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Immunology. ; Pharmacology. ; Immunology.
    Description / Table of Contents: Preface Chapter 1: Overview of the Immune System and its Pharmacological Targets -- Chapter 2: Modulation of the Innate Immune System -- Chapter 3: Modulation of the Adaptive Immune System -- Chapter 4: Respiratory Disorders of the Immune System and their Pharmacological Treatment -- Chapter 5: Inflammation of the Skin and its therapeutic topics -- Chapter 6: Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments -- Chapter 7: Mechanisms of Autoimmunity and Pharmacologic Treatments -- Chapter 8: Transplantation: Immunologic Principles and Pharmacologic Agents -- Chapter 9: Immunopathogenesis, Immunization, and Treatment of Infectious Diseases -- Chapter 10: Cancer Immunotherapy.
    Abstract: Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are discussed in detail. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.
    Type of Medium: Online Resource
    Pages: XIX, 399 p. 118 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030199227
    URL: https://doi.org/10.1007/978-3-030-19922-7
    DOI: 10.1007/978-3-030-19922-7
    DDC: 615
    Language: English
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    Rabies and Rabies Vaccines (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Virology. ; Immunology. ; Pharmacology. ; Virology. ; Immunology.
    Description / Table of Contents: Rabies Life Cycle, Transmission and Pathogenesis -- History of Rabies and Rabies Vaccines -- Rabies vaccines for wildlife -- Human Rabies Vaccines -- Rabies vaccines, prophylactic, Peru -- Rabies Prevention in Asia: Institutionalizing Implementation Capacities -- Passive Immunity in Rabies Prophylaxis -- Rabies Little Virus Against Powerful Innate Immunity -- Novel Rabies Vaccines -- Assessing the potency of inactivated veterinary vaccines and oral live vaccines against rabies -- WHO Perspective on Rabies.
    Abstract: This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine. .
    Type of Medium: Online Resource
    Pages: VII, 205 p. 15 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030210847
    URL: https://doi.org/10.1007/978-3-030-21084-7
    DOI: 10.1007/978-3-030-21084-7
    DDC: 615
    Language: English
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  • 48
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    Principles of Forensic Toxicology (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Forensic sciences. ; Medical jurisprudence. ; Pharmacology. ; Forensic Science. ; Forensic Medicine.
    Description / Table of Contents: Part 1: Introduction -- Post Mortem Forensic Toxicology -- Human Performance Toxicology -- Drug-Facilitated Sexual Assault -- Forensic Drug Testing -- Performance enhancing Drug Testing -- Drug Testing in Pain Management -- Pharmacokinetics and Pharmacodynamics -- Part II. Specimen Preparation -- Spectrophotometry -- Chromatography -- Derivatization -- Immunoassy -- Mass Spectrometry -- Quantitation -- Method Validation -- Measurement Uncertainty and Traceability -- Statistics in Forensic Toxicology -- Part III Analytes -- Alcohol -- Benzodiazapines -- Gammahydroxybutyric acid,- Miscellaneous Central Nervous System Depressants -- Opioids -- Cocanie -- Cannabis -- Amphetamines-Sympathomimetic Amines,- Hallucinogens and Psychedelics -- Antidepressants and Neuroleptics -- Miscellaneous Therapeutic Drugs -- Carbon Monoxide/Cyanide -- Inhalants -- Metals -- Part III Special Topics -- Stability of Drugs of Abuse in Biological Systems -- Postmortem Redistribution of Drugs -- Postmortem Clinical Testing -- Pharmacogenomics -- Hair Drug Testing -- Oral Fluid Testing -- Meconium Drug Testing -- Drugs in Embalmed Tissues.
    Abstract: The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner’s offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.
    Type of Medium: Online Resource
    Pages: XIII, 691 p. 188 illus., 23 illus. in color. , online resource.
    Edition: 5th ed. 2020.
    ISBN: 9783030429171
    URL: https://doi.org/10.1007/978-3-030-42917-1
    DOI: 10.1007/978-3-030-42917-1
    DDC: 615
    Language: English
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    Contract Research and Development Organizations-Their History, Selection, and Utilization (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacy. ; Pharmacology. ; Pharmacy.
    Description / Table of Contents: Introduction -- History of CROs: Including CRO Snapshots and a CRO Genealogy Chart -- The Pharmaceutical Development Process & Testing Requirements -- The Medical Device Development Process & Testing Requirements -- Functions and Types of CROs -- Labs in China and India -- Selection of CROs -- Study Directors and PIs -- Nuts and Bolts of Study Performance SCG/CBS -- Electronic Reporting Requirements (SEND & eCTD) -- Study and Project Monitoring -- Contracting, Pricing, and Cost of Works Performed by CROs -- Consultants and their Role -- Building Relationships: Maximizing your return on Expectations with a CRO -- Common Problems and their Solutions -- Appendices: A Toxicology Labs B Medical Device Labs C Phase I Labs D Analytical Labs E GMP Contract Facilities F Formulation G Dosage Forms H Clinical Testing I Regulatory Services J Forms and Checklists -- K Specialized Services -- L Consultants Known to be In-Practice -- Index. .
    Abstract: This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: · The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. · Study directors and principal investigators. · The nuts and bolts of study performance. · Electronic reporting requirements – SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). · Consultants and their roles. · An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs – where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities – and for auditing studies and projects at such facilities – are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.
    Type of Medium: Online Resource
    Pages: XIII, 519 p. 19 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030430733
    URL: https://doi.org/10.1007/978-3-030-43073-3
    DOI: 10.1007/978-3-030-43073-3
    DDC: 615
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    Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Surgery. ; Dentistry. ; Veterinary medicine. ; Neurology . ; Orthopedic surgery. ; Pharmacology. ; Surgery. ; Dentistry. ; Veterinary Science. ; Neurology. ; Surgical Orthopedics.
    Description / Table of Contents: 1. History of development of botulinum toxin therapy in medical and surgical fields -- 2. Molecular structure and mechanisms of action of botulinum toxins as it pertains to clinical symptoms -- 3. Types of toxins in commercial use, their similarities and differences -- 4. A review of current Botulinum toxin treatment indications in medical field. - 5. Mechanisms of Analgesic effects of botulinum neurotoxins -- 6. Botulinum toxin treatment in Head and neck surgery -- 7. Botulinum toxin treatment of thoracic and abdominal surgery -- 8. Botulinum Toxin A in Abdominal Wall Reconstruction -- 9. Use of Botulinum toxin A in post-mastectomy breast reconstruction -- 10. Botulinum Toxins for Treatment of Pain in Orthopedic Disorders -- 11. Botulinum toxin for pediatric patients, Who? For what? When? -- 12. Botulinum Toxin Treatment in Plastic Surgery -- 13. Botulinum Toxin Treatment in Ophthalmology and Ophthalmic surgery -- 14. Botulinum Toxin Treatment in Gastrointestinal Disorders -- 15. Botulinum Toxin Treatment in Urological Disorders -- 16. Botulinum Toxin Treatment in Dentistry -- 17. Botulinum toxin treatment in Veterinary Medicine - Clinical implications -- 18. Future Perspectives of Botulinum Toxin Application In Dentistry.
    Abstract: All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine and furnishes the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.
    Type of Medium: Online Resource
    Pages: VIII, 398 p. 70 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506919
    URL: https://doi.org/10.1007/978-3-030-50691-9
    DOI: 10.1007/978-3-030-50691-9
    DDC: 615
    Language: English
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    Nanoformulations in Human Health : Challenges and Approaches (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Therapeutics. ; Pharmacology. ; Therapeutics.
    Description / Table of Contents: Nano-technological Platforms and Manipulations for the Emerging Ocular Manifestations -- Phytonanomedicines as Topical Alternatives for the Treatment of Skin Cancer -- Nano-sized Labile and Particulate Ingredients in Topical Formulations: A Strategic Approach Against Photoageing and Photocarcinogenisis -- Application of Biocompatible Nanocarriers in Glaucoma: Challenges and Advances -- Nano-carriers for Natural Therapeutics in the Management of Neuropathic Pain -- Advances in the Delivery of Therapeutic Peptides -- Nanoformulations and Their Role in Colon Targeting -- Theranostic Nanoformulations: Merging Diagnostics and Therapeutics -- The Role of Nanoformulations in Nose-To-Brain Drug Delivery -- Cubic Lyotropic Liquid Crystalline Nanostructures: A Versatile Platform for Delivery -- Preformulation Challenges: The Concept Behind the Selection, Design, and Preparation of Nanoformulations -- Nanoethosomes for Topical Fungal Therapeutics -- Comparison of Therapeutic Efficiency of Nanoformulations of Curcumin vs. Tetrahydrocurcumin in Various Disorders -- Nanomedicinal Approaches of Phytotherapeutics to Treat Alzheimers Disease -- Nanoparticulate Approaches to Exploit the Pathophysiology of Rheumatoid and Osteoarthritis -- Emerging Nanotechnology in Chronic Respiratory Diseases -- Conventional and Non-conventional Approaches of Site-specific Targeting of Therapeutics in Some Infectious Diseases and Metabolic Disorders -- Nanoformulations in Human Health Conditions: The Paradigm Shift -- Magnetic Nanoparticles Nanoformulation for Alternative Therapy of Cancer by Super-paramagnetic Hyperthermia -- Nano-weapons Against Tuberculosis -- Drug-Excipient Interactions in Nanoformulations with Special Focus on Impurity Control per ICH guidelines.
    Abstract: This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.
    Type of Medium: Online Resource
    Pages: XVIII, 548 p. 106 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030418588
    URL: https://doi.org/10.1007/978-3-030-41858-8
    DOI: 10.1007/978-3-030-41858-8
    DDC: 615
    Language: English
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    Adventure Tourism : Environmental Impacts and Management (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Environment. ; Environmental management. ; Physical Geography. ; Environmental Sciences. ; Environmental Management.
    Description / Table of Contents: Chapter 1: What Is Adventure Tourism? -- Chapter 2: Adventure Tourism in Antarctica -- Chapter 3: The Arctic Islands: Svalbard and Iceland -- Chapter 4: Adventure Tourism in the Russian Arctic -- Chapter 5: Adventure Tourism in Greenland -- Chapter 6: Adventure Tourism in the Canadian Arctic -- Chapter 7: Adventure Tourism in Alaska -- Chapter 8: Adventure Tourism in the Himalayas -- Chapter 9: The Andes -- Chapter 10: East Africa -- Chapter 11: Australia and New Zealand -- Chapter 12: Scotland -- Chapter 13: Climate Change and Adventure Tourism.
    Abstract: This textbook presents a comprehensive overview of the environmental impacts of various types of adventure tourism and how these can be best managed. This volume follows on from the authors' previous textbook – ‘Outdoor Recreation: Environmental Impacts and Management’ and continues the aim of developing a deeper understanding of how tourist numbers impact the environment and to provide practical solutions to these problems. Combining their own first-hand experience and research with extensive literature review the authors present several popular adventure tourism destinations from across the globe, including the Arctic, the Himalayas, Africa, Australia and Scotland as case studies. Chapters cover the particular challenges faced by each region: including impacts on animals and birds; the spread of invasive plant species and diseases; trail impacts on vegetation; impacts on geological, historical and archaeological sites and pollution and waste issues. A discussion and evaluation of the possible management actions for minimising these impacts and how outdoor recreation tourists can be regulated concludes each chapter. This practical and engaging textbook will be invaluable to students and scholars of adventure tourism and outdoor recreation as well as practitioners and managers working in the field. David Huddart is Emeritus Professor at Liverpool John Moores University, UK. He has extensive experience teaching landscape interpretation, recreation ecology, and outdoor and environmental education. Tim Stott is Professor of Physical Geography and Outdoor Education at Liverpool John Moores University, UK. He has been responsible for leading and teaching on the Outdoor Education programmes for 25 years.
    Type of Medium: Online Resource
    Pages: XXX, 475 p. 141 illus., 131 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030186234
    URL: https://doi.org/10.1007/978-3-030-18623-4
    DOI: 10.1007/978-3-030-18623-4
    DDC: 910.02
    Language: English
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    Frontier Making in the Amazon : Economic, Political and Socioecological Conversion (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Human geography. ; Agriculture Economic aspects. ; Economic geography. ; Cultural geography. ; America Politics and government. ; Physical Geography. ; Human Geography. ; Agricultural Economics. ; Economic Geography. ; Social and Cultural Geography. ; American Politics.
    Description / Table of Contents: Introduction: Frontier thinking and the Amazon region -- Scarcities and abundances in place and time: A proposed conceptualisation of frontier making -- Placing the agricultural frontier of Mato Grosso, Brazil -- Peasant farming in the Amazon frontiers -- Water and energy frontiers in the Amazon -- Production of poverty and the poverty of production in the Amazon -- Disrupting frontier development from within: The latent geographical agency of indigenous peoples -- Development and conservation frontiers in the Pantanal wetland -- Conclusion: Lessons learned to expand frontier theory.
    Abstract: This book discusses the outcomes of more than ten years of research in the southern tracts of the Amazon region, and addresses the expansion of the agricultural frontier, consolidation of the agribusiness-based economy, and expansion of regional infrastructure (roads, dams, urban centres, etc). It combines extensive empirical evidence with the international literature on frontier-making and regional Amazonian development, and adopts a critical politico-geographical perspective that will benefit scholars in various other disciplines. This book is intended to push the current theoretical and methodological boundaries regarding the controversies and impacts of agribusiness in the region. A new international scientific network, led by the author, is investigating the broader context of the themes analysed here. .
    Type of Medium: Online Resource
    Pages: XIII, 222 p. 33 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030385248
    Series Statement: Key Challenges in Geography, EUROGEO Book Series,
    URL: https://doi.org/10.1007/978-3-030-38524-8
    DOI: 10.1007/978-3-030-38524-8
    DDC: 910.02
    Language: English
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  • 54
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    Plant Landscape of Corsica : Typology and Mapping Plant Landscape of Cap Corse Region and Biguglia Pond (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Landscape ecology. ; Environmental monitoring. ; Physical Geography. ; Landscape Ecology. ; Environmental Monitoring.
    Abstract: Since the 1970s and particularly the works of Tüxen (1978) and Géhu & Rivas-Martínez (1981), dynamico-catenal phytosociology has facilitated the integration of vegetation dynamics by more precisely describing the trajectories of vegetation series. A national habitat mapping program (CarHAB), launched by France’s Ministry of Ecology, aims to map the vegetation and vegetation series of metropolitan France at a scale of 1: 25,000 by 2025. In this context, Corsica has been selected as a pilot region, due to its unique characteristics regarding Mediterranean and alticole vegetation. This book describes in detail the vegetation series and geoseries (ecology, structure, dynamic trajectories, effects of anthropogenic factors on vegetation dynamics, catenal positioning in the landscape) of two Corsican sectors: Cap Corse and Biguglia pond. These two study sites were selected using two methods: • For Cap Corse, the typology and mapping are based on an inductive approach, which seeks to understand the dynamics of vegetation by drawing on the mature, substitutional, pioneering and anthropogenic associations likely to exist within a tessellar envelope. These various dynamic stages characterize “the vegetation series” (sigmetum or synassociation), the fundamental unit of symphytosociology (Géhu 2006; Biondi 2011). The aim of symphytosociology is, therefore, to define the vegetation series; in other words, it seeks to identify the repetitive combinations of syntaxa under homogeneous ecological conditions. • For Biguglia pond, the typology and mapping are based on a deductive approach, which combines (under SIG) the ecological descriptor maps with the vegetation mapping, in order to reveal the tesselas and the natural potential vegetation that underlies them. Thanks to the improvement of GIS techniques, this approach has been frequently used to characterize plant landscapes from vegetation to vegetation geoseries since the 2000s, with applications to the conservation management of natural and semi-natural environments.
    Type of Medium: Online Resource
    Pages: IX, 210 p. 87 illus., 82 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357764
    Series Statement: Geobotany Studies, Basics, Methods and Case Studies,
    URL: https://doi.org/10.1007/978-3-030-35776-4
    DOI: 10.1007/978-3-030-35776-4
    DDC: 910.02
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    Nature in the Built Environment : Global Politico-Economic, Geo-Ecologic and Socio-Historical Perspectives (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Environmental sciences Social aspects. ; Environment. ; Economic development. ; Physical Geography. ; Environmental Social Sciences. ; Environmental Sciences. ; Development Studies.
    Description / Table of Contents: Chapter 1. Environmental Stewardship and Built Space -- Chapter 2. PESTECH and Nature in Built Space: Analytical Framework -- Chapter 3. Nature in Built Space in Sub-Saharan Africa -- Chapter 4. Nature in Built Space in the MENA Region -- Chapter 5. Nature in Built Space in Asia and the Pacific -- Chapter 6. Nature in Built Space in Latin America and the Caribbean -- Chapter 7. Nature in Built Space in North America -- Chapter 8. Nature in Built Space in Western Europe.
    Abstract: A good understanding of the status quo is necessary for the success of efforts to develop and maintain nature in built space. Accordingly, this book conducts an environmental scan of the context of these efforts in global perspective. In particular, it develops and employs a novel environmental scanning model (ESM) designed to rigorously analyze the political, economic, social, technological, ecological, cultural and historical (PESTECH) contexts of initiatives to promote biodiversity in the built environment. The focus is on four specific substantive areas of environmental policy, namely forestry, water, food, and energy. The units of analysis roughly correspond with the major United Nations Environmental Programme (UNEP) regions of the world, including sub-Saharan Africa, Middle-East and North Africa, Asia and the Pacific, Western Europe, North America, and Latin America and the Caribbean.
    Type of Medium: Online Resource
    Pages: IX, 209 p. 6 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030397593
    URL: https://doi.org/10.1007/978-3-030-39759-3
    DOI: 10.1007/978-3-030-39759-3
    DDC: 910.02
    Language: English
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    Voyages on the Northern Sea Route (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Transportation engineering. ; Traffic engineering. ; Climatology. ; Physical Geography. ; Transportation Technology and Traffic Engineering. ; Climate Sciences.
    Description / Table of Contents: Part I. Problems of planning vessel voyages in ice -- Chapter 1. Introduction -- Part II. Overcoming ice and speed of a vessel -- Chapter 2. The ability to overcome ice and speed of vessel navigating independently in ice -- Part III. Dangerous phenomena and hazards to shipping -- Chapter 3. Dangerous hydro-meteorological phenomena occurring on the NSR -- Part IV. Suggested routes and voyahe dates -- Chapter 4. Routes outside ice-covered zones on the NSR for vessels without ice strengthening -- Chapter 5. Dates of opening and closing of the seas for ice-free navigation -- Part V. Models of decision-making systems -- Chapter 6. Decision-making system of initial voyage planning -- Chapter 7. Operational voyage planning and verification of the initial voyage planning system -- Chapter 8. Summary and conclusions -- Appendices.
    Abstract: This book explains vessels’ ability to overcome ice on the Northern Sea Route, as well as the criteria of safe speed and maneuvering of vessels on ice. It provides a successful long-term forecast of ice navigation and reveals the dangers of sailing on the Northern Sea Rote, It includes tips on how to plan and schedule voyages in the Russian Arctic. The book develops a set of suggested routes for the period of opening and closing of the transit ice-free zone through the NSR based on the last eleven navigation seasons. It presents a method for determining the date for beginning a voyage of a vessel without ice strengthening through the NSR. It also develops a model of initial (long-term) and operational decision-making support system for vessel voyage planning and scheduling. The main audience for the book are officers at operational and management level of competency, people planning voyages on the Northern Sea Route in the office of ship operator and in chartering department or consulting company, and participants of Ice Navigator IMO Model Courses at basic and advanced level of competency.
    Type of Medium: Online Resource
    Pages: XXXVIII, 279 p. 317 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030254902
    URL: https://doi.org/10.1007/978-3-030-25490-2
    DOI: 10.1007/978-3-030-25490-2
    DDC: 910.02
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    Opening and Closure of the Neuquén Basin in the Southern Andes (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Water. ; Hydrology. ; Geology. ; Paleoecology. ; Sedimentology. ; Physical Geography. ; Water. ; Geology. ; Paleoecology. ; Sedimentology.
    Description / Table of Contents: The Neuquén Basin: Stratigraphy, subsidence controls and basin closure -- Heterogeneities and syn-rift evolution of Late Triassic-Early Jurassic Precuyano Cycle -- Structure of the Precuyo synrift in the Valenciana depocenter -- Structure of the Precuyo synrift in the Cara Cura-Sierra de Reyes depocenter -- Early Jurassic magmatism -- High-resolution sequence stratigraphy and main controls of the Middle Jurassic Cuyo Group -- Depositional environments and hyperpycnal shelfal sedimentation in the Late Jurassic Lotena Formation -- Environmental controls and facies architecture of a Late Jurassic (Oxfordian) carbonate episode (La Manga Formation) -- The Cuyo and lower Mendoza cycles in the Aconcagua fold and thrust belt -- The extensional control of the Late Jurassic units -- Morphostructural configuration and sedimentary evolution of the Late Jurassic – Early Cretaceous Vaca Muerta –Quintuco system -- Magnetostratigraphy of the Early Jurassic – Early Cretaceous in the Neuquén Basin -- Orbital controls and high-resolution cyclostratigraphy of Late Jurassic – Early Cretaceous in the Neuquén Basin (Lower Callovian – Early Barremian) -- Sedimentary evolution of the continental Late Cretaceous Neuquén Group -- The Cretaceous contractional stage and the first synorogenic basin in the Neuquén Basin -- The origin of the Malargüe Basin -- The Late Cretaceous-Paleocene extension -- The Paleocene to early Oligocene lull -- Causes and extent of the Oligocene extension -- The Late Cretaceous to Oligocene magmatism -- The Miocene orogenesis related to the subduction of the Payenia hot spot -- The Miocene magmatism in the Malargüe fold and thrust belt -- The structure of the Malargüe fold and thrust belt -- Thermochronological constraints on the exhumation of the Malargüe fold and thrust belt -- Structure and thermochronological constraints on the exhumation of the Chos Malal fold and thrust belt -- The structure and exhumation of the Agrio fold and thrust belt -- The Quaternary deformation in the Neuquén Basin and the impact of the Payenia hot spot.
    Abstract: This book provides an overview of newly gathered material focusing on the opening and closure of The Neuquén Basin. The Neuquén Basin contains the most important hydrocarbon reservoirs in Argentina and therefore is characterized by a profound knowledge of the sedimentation mechanisms and closure times. During the last 10 years a considerable amount of new information has been produced that illustrates a complex evolution that involves more than one synrift stage during its evolution, an aborted sag phase associated with the inception of a first foreland basin in late Early Cretaceous times, two extensional destabilizations in the Late Cretaceous-Paleocene and late Oligocene times and a Neogene magmatic expansion coetaneous to a last mountain building. These processes have produced a polyphasic complex structure that exhumed the rich sedimentary record that characterizes the basin.
    Type of Medium: Online Resource
    Pages: XX, 513 p. 177 illus., 165 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030296803
    Series Statement: Springer Earth System Sciences,
    URL: https://doi.org/10.1007/978-3-030-29680-3
    DOI: 10.1007/978-3-030-29680-3
    DDC: 910.02
    Language: English
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    Deltas in the Anthropocene (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Environment. ; Economic development. ; Environmental management. ; Physical Geography. ; Environmental Sciences. ; Development Studies. ; Environmental Management.
    Description / Table of Contents: 1. Delta challenges and trade-offs from the Holocene to the Anthropocene -- 2. Ganges-Brahmaputra-Meghna Delta, Bangladesh and India: A transnational mega-delta -- 3. The Mahanadi Delta: A rapidly developing delta in India -- 4. The Volta Delta, Ghana: challenges in an African setting -- 5. Fluvial sediment supply and relative sea-level rise -- 6. Hotspots of present and future risk within deltas; hazards, exposure and vulnerability -- 7. Where people live and move in deltas -- 8. Delta economics and sustainability -- 9. Adapting to change: People and policies -- 10. Choices: Future trade-offs and plausible pathways -- 11. Sustainable deltas in the Anthropocene.
    Abstract: The Anthropocene is the human-dominated modern era that has accelerated social, environmental and climate change across the world in the last few decades. This open access book examines the challenges the Anthropocene presents to the sustainable management of deltas, both the many threats as well as the opportunities. In the world’s deltas the Anthropocene is manifest in major land use change, the damming of rivers, the engineering of coasts and the growth of some of the world’s largest megacities; deltas are home to one in twelve of all people in the world. The book explores bio-physical and social dynamics and makes clear adaptation choices and trade-offs that underpin policy and governance processes, including visionary delta management plans. It details new analysis to illustrate these challenges, based on three significant and contrasting deltas: the Ganges-Brahmaputra-Meghna, Mahanadi and Volta. This multi-disciplinary, policy-orientated volume is strongly aligned to the United Nation’s Sustainable Development Goals as delta populations often experience extremes of poverty, gender and structural inequality, variable levels of health and well-being, while being vulnerable to extreme and systematic climate change. Robert J Nicholls is Professor of Coastal Engineering within Engineering and Physical Sciences at the University of Southampton, UK. He has contributed to a wide range of influential national and international publications including the IPCC Assessment Reports. W Neil Adger is Professor of Human Geography at the University of Exeter, UK. His research examines demographic, political economy, public health and well-being aspects of the Anthropocene. Craig W Hutton is Professor of Sustainability Science within Geography and Environment at the University of Southampton, UK. His research focuses on spatial analysis of vulnerability and the incorporation of sustainable management, policy and governance into decision-making processes. Susan E Hanson is Research Fellow within Engineering and Physical Sciences at the University of Southampton, UK. She specializes in coastal vulnerability and management, particularly as a consequence of climate change.
    Type of Medium: Online Resource
    Pages: XXXIII, 282 p. 55 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030235178
    URL: https://doi.org/10.1007/978-3-030-23517-8
    DOI: 10.1007/978-3-030-23517-8
    DDC: 910.02
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    Inland Dunes of North America (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Geography. ; Sedimentology. ; Environment. ; Physical Geography. ; Earth System Sciences. ; Regional Geography. ; Sedimentology. ; Environmental Sciences.
    Description / Table of Contents: Chapter1. Introduction -- Chapter2. Quaternary Eolian Dunes and Sand Sheets in Inland Locations of the Atlantic Coastal Plain Province, U.S.A. -- Chapter3. Dunes of the Laurentian Great Lakes -- Chapter4. The Central and Southern Great Plains -- Chapter5. The Nebraska Sand Hills -- Chapter6. White Sands -- Chapter7. Great Sand Dunes -- Chapter8. Colorado Plateau -- Chapter9. Southwest Deserts.
    Abstract: Inland sand dunes are widespread in North America and are found from the North Slope of Alaska to the Sonoran Desert in northern Mexico and from the Delmarva Peninsula in the east to Southern California in the west. In this edited book, we highlight recent research on areas of inland dunes that span a range from those that are actively accumulating in current conditions of climate and sediment supply to those that were formed in past conditions and are now degraded relict systems. This book will be of interest to researchers and scholars of physical geography, geomorphology, environmental sciences, and earth sciences. Contributions include detailed analyses of individual active dune systems at White Sands, New Mexico; Great Sand Dunes, Colorado; and the Laurentian Great Lakes; as well as the vegetation-stabilized dunes of the Nebraska Sand Hills and the Colorado Plateau. Additional chapters discuss the widespread partially vegetated dune systems of the central and southern Great Plains; the relict dunes of the Atlantic Coastal Plain of the eastern USA; and active and stabilized dunes of the Colorado Plateau and the southwestern deserts of the USA and northern Mexico. .
    Type of Medium: Online Resource
    Pages: IX, 337 p. 126 illus., 97 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030404987
    Series Statement: Dunes of the World,
    URL: https://doi.org/10.1007/978-3-030-40498-7
    DOI: 10.1007/978-3-030-40498-7
    DDC: 910.02
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    Mapping and Spatial Analysis of Socio-economic and Environmental Indicators for Sustainable Development : Case Studies from North Africa (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Regionalism. ; Regional economics. ; Spatial economics. ; Sustainability. ; Human geography. ; Geology. ; Physical Geography. ; Regionalism. ; Regional and Spatial Economics. ; Sustainability. ; Human Geography. ; Geology.
    Abstract: This book presents most recent research studies on mapping and spatial analysis of socio-economic and environmental indicators used by various national and international contributors to regional development projects. It gathers the best contributions to the 1st International Conference on Mapping and Spatial Analysis of Socio-Economic and Environmental Indicators for the Local and Regional Sustainable Development. The conference was held in southern Tunisia, Tataouine in March 2015.The research studies focused on generating and analyzing indicators in various domains of Agriculture, Energy, Industry, Tourism, Transport, Urban Planning, Exploitation of Natural Resources, Infrastructure, Health, Environment, Education, Information and Communication Technologies, Social Affairs and Employability, and Culture and Sport. Socio-economic and environmental indicators are important in regional development plans and strategies as they allow to observe and analyze changes in the economic growth and to measure their impact on the environment and on social networks/daily life of citizens. On the basis of well-defined geomatic approaches, and particularly, through sophisticated digital mapping and spatio-temporal analyses, authors focused on retrieving indicators to evaluate the exploitation rate of natural resources, intensity of the energy consumption in various economic sector, net migratory flows, quality checking of the air in urban areas, adaptation to climate change, and vulnerability of the coastal domain and risk of marine submersion due to sea-level rise. The book is of interest not only to investors and contributors to regional development projects, but also to all relevant policy makers. .
    Type of Medium: Online Resource
    Pages: XII, 167 p. 132 illus., 111 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030211660
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    URL: https://doi.org/10.1007/978-3-030-21166-0
    DOI: 10.1007/978-3-030-21166-0
    DDC: 910.02
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    Latin America in Times of Global Environmental Change (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Climatology. ; America Politics and government. ; Sustainability. ; Environmental monitoring. ; Physical Geography. ; Climate Sciences. ; American Politics. ; Sustainability. ; Environmental Monitoring.
    Description / Table of Contents: Preface -- Challenges of Latin America in the Global Environmental Geopolitics of the XXI Century (Fernando Estenssoro Saavedra) -- Dilemmas and Opportunities of the South American Transboundary Basins and Integration (Ana Emérica Seitz) -- Scientific Knowledge Regarding Natural Resources in South America: Conditioning Factors and Strategic Challenges for the Region (Rosina Soler) -- Identity-based Cooperation in the Multilateral Negotiations on Climate Change: The Group of 7 and China (María del Pilar Bueno) -- Public Concern on Climate Change: Taking Stock and Testing Hypotheses in Latin America (Patricio Yamin) -- International Environmental Funds: Between Domestic Policies and the Foreign Relations of Argentina (Cristian Lorenzo) -- Index.
    Abstract: This volume discusses the challenges of Latin America in global environmental geopolitics. Written by leading experts, this book brings together Latin American research on global environmental change. They cover a range of topics such as climate change, water, forest and biodiversity conservation connected with science policies, public opinion, priorities of international funds, and international politics of Latin American countries. The book describes the discrepancy between the international priorities and the regional needs or country interests. It includes several case studies and analyses the cooperation in multilateral negotiations on climate change. It also offers a synthesis of debates around global environmental changes and Latin American politics, which the authors have previously promoted in different academic events in South America, including in Santiago de Chile in Chile, and Buenos Aires and Ushuaia in Argentina. This book assesses the environmental problems from different perspectives, highlights the scientific development in the environmental changes affecting Latin America and offers a new view on geopolitics to help face those issues. Specialist readers in international relations, political sciences, environmental sciences, geography and geopolitics will appreciate this up-to-date examination of Latin America and the global environmental change.
    Type of Medium: Online Resource
    Pages: XIV, 181 p. 12 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030242541
    Series Statement: The Latin American Studies Book Series,
    URL: https://doi.org/10.1007/978-3-030-24254-1
    DOI: 10.1007/978-3-030-24254-1
    DDC: 910.02
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    Integrated Modelling of Ecosystem Services and Land-Use Change : Case Studies of Northwestern Region of China (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Physical geography. ; Landscape ecology. ; Physical Geography. ; Landscape Ecology.
    Description / Table of Contents: Integrated modelling of land use and cover change -- An integrated analysis approach to LUCC process at regional scale -- Modeling urban growth with CA model at regional scale Chapter 3 Detecting vegetation change with trend analysis of NDVI time series -- Integrated assessing of ecosystem services -- Forecast optimization of wind power service by integrating CFD and Kalman filtering -- Integrated modelling of hydrologic regulating service -- Assessing of climate regulating service– example of extreme weather -- Assessing the valuation of multiply ecosystem services -- Integrated modelling of ecosystem services and land-use change -- Simulating land-use change and its effect on biodiversity conservation -- Integrated ecosystem services assessment in urbanizing regions.
    Abstract: This book presents essential case studies on the integrated modelling of ecosystem services and land-use change in the field of landscape ecology. The case studies were mainly conducted in the Zhangye oasis of the Hexi corridor and the upper reaches of the Heihe river basin, including Loess plateau (for wind power) and the inland waterways of the Yangtze River (for the regulation of extreme events). The book puts forward an integrated modelling method, including human activities, natural processes, land-use change, and ecosystem management, and explores multiple scenarios based on the interests of local managers and their implications for ecosystem services. As the book demonstrates, the integrated modelling method for ecosystem services and land-use change can serve as a valuable tool for gauging the impact of various development scenarios in this study area, and in other regions with similar characteristics. In addition, numerous charts and diagrams are included in each chapter, facilitating the simulation and assessment of specific land-use change impacts on ecosystem services in various study areas.
    Type of Medium: Online Resource
    Pages: X, 182 p. 77 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811391255
    Series Statement: Springer Geography,
    URL: https://doi.org/10.1007/978-981-13-9125-5
    DOI: 10.1007/978-981-13-9125-5
    DDC: 910.02
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    Arctic Sea Ice Ecology : Seasonal Dynamics in Algal and Bacterial Productivity (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Freshwater ecology. ; Marine ecology. ; Oceanography. ; Environment. ; Conservation biology. ; Ecology . ; Physical Geography. ; Freshwater and Marine Ecology. ; Ocean Sciences. ; Environmental Sciences. ; Conservation Biology. ; Earth System Sciences.
    Description / Table of Contents: Chapter 1. The Book, and Ecology of Sea Ice -- Chapter 2. Autumn, Development and Consolidation of Sea Ice -- Chapter 3. Winter, Cold and Mature Sea Ice -- Chapter 4. Spring, Summer and Melting Sea Ice -- Chapter 5. Sea Ice in a Climate Change Context -- Chapter 6. Methods and Techniques in Sea Ice Ecology.
    Abstract: The book on sea ice ecology is the ecology of sea ice algae and other microorganism as bacteria, meiofauna, and viruses residing inside or at the bottom of the sea ice, called the sympagic biota. Organisms as seals, fish, birds, and Polar bears relies on sea ice but are not part of this biota. A distinct feature of this ecosystem, is the disappearance (melt) every summer and re-establishing in autumn and winter. The book is organized seasonally describing the physical, optical, biological, and geochemical conditions typical of the seasons: autumn, winter, and spring. These are exemplified with case studies based on author’s fieldwork in Greenland, the Arctic Ocean, and Antarctica but focused on Arctic conditions. The sea ice ecosystem is described in the context of climate change, interests, and effects of a decreasing summer ice extent in the Arctic Ocean. The book contains an up to date description of most relevant methods and techniques applied in sea ice ecology research. This book will appeal to university students at Masters or PhD levels reading biology, geosciences, and chemistry.
    Type of Medium: Online Resource
    Pages: XIV, 178 p. 130 illus., 103 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030374723
    Series Statement: Springer Polar Sciences,
    URL: https://doi.org/10.1007/978-3-030-37472-3
    DOI: 10.1007/978-3-030-37472-3
    DDC: 910.02
    Language: English
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    Pharmacogenomics in Precision Medicine : From a Perspective of Ethnic Differences (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Pharmacology. ; Biomedical Research. ; Medical Genetics.
    Description / Table of Contents: Chapter 1. Introduction and Principles of Pharmacogenomics and Precision medicine -- Chapter 2. Pharmacogenomics in Cardiovascular Diseases -- Chapter 3. Pharmacogenomics of Antitumor Chemotherapeutic Agents -- Chapter 4. Pharmacogenomics of Antitumor Targeted Agent and Immunotherapy -- Chapter 5. Pharmacogenomics of Immunosuppressant -- Chapter 6. Pharmacogenomics of Psychiatric drugs -- Chapter 7. Pharmacogenomics of Anti-Infective Agents -- Chapter 8. Pharmacogenomics of Antithrombotic drugs -- Chapter 9. Pharmacogenomics in Therapeutic Drug Monitoring -- Chapter 10. Pharmacomicrobiomics -- Chapter 11. Genotyping technology in Pharmacogenomics -- Chapter 12. The Ethical, Legal and Regulatory Issues Associated with Pharmacogenomics -- Chapter 13. Cost-effectiveness of pharmacogenetic-guided treatment -- Chapter 14. Application of pharmacogenomics in drug discovery and development -- Chapter 15. Barriers and Solutions in Clinical Implementation of Pharmacogenomics for Personalized Precision Medicine.
    Abstract: This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.
    Type of Medium: Online Resource
    Pages: VIII, 289 p. 33 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811538957
    URL: https://doi.org/10.1007/978-981-15-3895-7
    DOI: 10.1007/978-981-15-3895-7
    DDC: 615
    Language: English
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    Nanotechnology in Skin, Soft Tissue, and Bone Infections (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical microbiology. ; Dermatology. ; Orthopedic surgery. ; Pharmacology. ; Medical Microbiology. ; Dermatology. ; Surgical Orthopedics.
    Description / Table of Contents: Part 1-Nanotechnology in Skin Infections -- Atopic dermatitis and current trends in pharmacological treatment - a nanoparticulate approach -- Acne vulgaris - recent trends on pharmacological and nanotechnological approaches in therapeutics -- Nitric oxide nanoparticles on skin infections: Current State and Future Prospects -- Metal Nanoparticles Based Antibacterial Nanocomposites for Skin Infections -- Combination therapy using metal nanoparticles for skin infection -- Applications of nanometals in cutaneous infections -- Antifungal nanotherapy: a novel approach to combat superficial fungal infections -- Biocompatible polymers for skin Nanomedicines -- Part 2-Nanotechnology on Soft-Tissue Infections -- Nanotechnological approach to manage diabetic foot ulcer -- Metal nanoparticles in wound infections -- Advances in nanomedicine for burn wound infection treatment -- Applications of chitosan in formulation of novel antibacterial agents and wound dressings -- Polymeric nanocomposites for skin and soft tissues -- Nanoformulations of polyphenols for the treatment of soft tissues infections -- Cutting Edge Nanotechnologies for Targeting Liver Disorders -- NanoCurcumin compounds formulations: Perspectives in skin and soft tissues infections -- Nanobiotechnology strategies for the treatment tegumentary and visceral leishmaniases, and emergence resistance -- Part 3-Nanotechnology in Bone Infections -- Artificial Scaffolds for Bone Tissue Engineering -- The bone biology and the nanotechnology for bone infections and bone engineering -- Part 4-Nanotechnology and Toxicity -- Genotoxicity studies of Silver Nanoparticles in in vivo and in vitro models.
    Abstract: The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft-Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.
    Type of Medium: Online Resource
    Pages: XI, 285 p. 39 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030351472
    URL: https://doi.org/10.1007/978-3-030-35147-2
    DOI: 10.1007/978-3-030-35147-2
    DDC: 615
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    Lipid Signaling in Human Diseases (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Cancer. ; Clinical biochemistry. ; Pharmacology. ; Cancer Biology. ; Medical Biochemistry.
    Description / Table of Contents: Part 1. New Roles for Sphingolipid Signaling and Cell Function -- 1. Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma -- 2. Exploring the Therapeutic Landscape of Sphingomyelinases -- 3. Sphingosine kinases as druggable targets -- Part 2. Phospholipase D and Mitogen Phosphatidic Acid in Human Disease -- 4. Prospects for PLD inhibition in cancer and thrombotic disease -- 5. Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer -- 6. Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease -- Part 3. Lipid Kinases and Novel Regulatory Pathways -- 7. Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors -- 8. Functions of Nuclear Polyphosphoinositides -- Part 4. Bioactive Lipids in Health and Disease -- 9. Platelet-Activating Factor as an Effector for Environmental Stressors -- 10. Phospholipase D and Choline Metabolism -- Part 5- Lipids and Membrane Microdomains -- 11. Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology -- 12. Lipids and Membrane Microdomains: The Glycerolipid and Alkylphosphocholine Class of Cancer Chemotherapeutic Drugs -- Part 6. Nuclear Trafficking of Lipids -- 13. Inositide-Dependent Nuclear Signalling in Health and Disease -- 14. Lipids in Exosome Biology.
    Abstract: Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important. .
    Type of Medium: Online Resource
    Pages: XIV, 336 p. 50 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030336684
    Series Statement: Handbook of Experimental Pharmacology, 259
    URL: https://doi.org/10.1007/978-3-030-33668-4
    DOI: 10.1007/978-3-030-33668-4
    DDC: 615
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    Early-life Environmental Exposure and Disease : Facts and Perspectives (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Gynecology . ; Environmental health. ; Pharmacology. ; Gynecology. ; Environmental Health.
    Description / Table of Contents: Preface -- Environmental Exposure Measurements and Evaluations -- Prenatal Smoke Exposure and Child Health -- Prenatal Pesticide Exposure and Child Health -- Prenatal Metal Exposure and Child Health -- Prenatal Stress and Child Health -- The Special Vulnerabilities of Child to Environmental Hazards -- Early-life Environmental Influences on Growth -- Early-life Environmental Influences on Neural Development -- Early-life Environmental Influences on Allergic Diseases -- Early-life Social and Economic Adversities on Health -- Endocrine Disrupting Chemical Exposure and Later-onset Diseases -- Paternal Specific Exposure and Child Health -- Molecular Mechanism of Early-life Chemical Exposure Induced Harmful Effects -- Transgenerational Effects on Developmental Origins of Diseases.
    Abstract: This book offers valuable insights into the latest concepts and findings from epidemiologic, clinical and basic studies in the burgeoning area of early-life environmental exposure and diseases. The book is divided into five parts, starting with an overview of environmental exposure measurement and evaluation, followed by a review of the effects of exposure to various substances like tobacco smoke, pesticides and metals as well as stress on offspring’s health. It then discusses the developmental origins of a range of childhood diseases that affect growth, neural development and the immune system, and highlights the importance of longitudinal studies that measure exposure at potentially sensitive time points during childhood. It also provides up-to-date evidence of the intergenerational/transgenerational effects of early-life environmental exposure, especially via genetic and epigenetic pathways. Allowing readers to gain a thorough understanding of the predominating aspects of early-life environmental exposure and diseases, the book also provides a basis for developing environmental and health policies that could have wide and long-term impacts on human health. .
    Type of Medium: Online Resource
    Pages: XVI, 239 p. 22 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811537974
    URL: https://doi.org/10.1007/978-981-15-3797-4
    DOI: 10.1007/978-981-15-3797-4
    DDC: 615
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    The Science and Business of Drug Discovery : Demystifying the Jargon (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacovigilance. ; Pharmaceutical chemistry. ; Chemistry, Physical and theoretical. ; Biotechnology. ; Pharmacology. ; Drug Safety and Pharmacovigilance. ; Pharmaceutics. ; Theoretical Chemistry. ; Biotechnology.
    Description / Table of Contents: Introduction -- PART 1: How Drugs are Discovered and Developed in the Pharmaceutical Industry -- Introduction to Drugs and Drug Targets -- Background to chemistry of small and large molecules -- Laying the foundations- Drug discovery from antiquity to the twenty first century -- Part II-The drug development pipeline – discovery to testing in humans -- Drug discovery pipeline overview -- Target discovery -- Medicinal chemistry -- Biotherapeutics -- Screening for hits -- Process chemistry and formulation -- Preclinical development -- Part III-The drug development pipeline – clinical trials to marketing authorisation -- Clinical trials -- Regulatory affairs and marketing approval -- Diagnostics and personalized medicine -- Putting it All Together: a drug development case history -- Part IV- The Global Pharmaceuticals Business -- Commercial aspects of drug development -- Challenges and responses -- Part V - Professional Interactions with the Drug Discovery Industry.-Professional Interactions with the Drug Discovery Industry: Technology Transfer Executives -- Recruitment Executives -- Pharmaceutical translators and Interpreters.
    Abstract: The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the twenty chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators .
    Type of Medium: Online Resource
    Pages: XVII, 402 p. 102 illus., 20 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030578145
    URL: https://doi.org/10.1007/978-3-030-57814-5
    DOI: 10.1007/978-3-030-57814-5
    DDC: 615
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    Interpenetrating Polymer Network: Biomedical Applications (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Medicinal chemistry. ; Polymers. ; Biotechnology. ; Pharmacology. ; Medicinal Chemistry. ; Polymers. ; Biotechnology.
    Description / Table of Contents: Chapter 1. Interpenetrating Polymer Network in Microparticulate Systems: Drug Delivery and Biomedical Application -- Chapter 2. Interpenetrating Polymer Network (IPN) Nanoparticles for Drug Delivery Applications -- Chapter 3. Fabrication Technology of Chitosan-Based IPN: Drug Delivery Application -- Chapter 4. Alginate based Interpenetrating Network Carriers for Biomedical Applications -- Chapter 5. pH Sensed Interpenetrating Polymeric Network: Application in drug delivery -- Chapter 6. IPN Dendrimers in Drug Delivery -- Chapter 7. BioproteinBased IPN Nanoparticles as Potential Vehicles for Anticancer Drug Delivery: Fabrication Technology -- Chapter 8. Semi-IPN systems for drug delivery -- Chapter 9. IPN Systems for Cancer Therapy -- Chapter 10. Semi-interpenetrating networks based on (meth)acrylate, itaconic acid and poly(vinyl pyrrolidone) hydrogels for biomedical applications -- Chapter 11. Biomedical Applications of Interpenetrating Polymer Network Gels -- Chapter 12. Bio-Nanocomposite IPN for Biomedical Application.-.
    Abstract: The book focuses on novel interpenetrating polymer network (IPN)/semi-IPN technologies for drug delivery and biomedical applications. The dynamism of the design and development of interpenetrating network polymers is based on their ability to provide free volume for the easy encapsulation of drugs in the three-dimensional network structure obtained by cross-linking two or more polymer networks. Natural polymer-based IPNs can deliver drugs at a controlled rate over an extended period of time, while novel IPNs ensure better mechanical strength and sustained/ controlled drug-delivery properties. This book presents an overview of the use of this technology to fabricate nanomedicine, hydrogels, nanoparticles, and microparticles, thereby unlocking IPN’s potential in the area of drug delivery and biomedical engineering. It also discusses applications of IPN systems in cancer therapy and tissue engineering, and describes the various IPN systems and their wide usage and applications in drug delivery.
    Type of Medium: Online Resource
    Pages: XII, 337 p. 59 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811502835
    URL: https://doi.org/10.1007/978-981-15-0283-5
    DOI: 10.1007/978-981-15-0283-5
    DDC: 615
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    Model Organisms to Study Biological Activities and Toxicity of Nanoparticles (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Nanotechnology. ; Biology Technique. ; Pharmacology. ; Human Physiology. ; Nanotechnology. ; Experimental Organisms.
    Description / Table of Contents: Chapter 1. Nanotechnology : Application in biology and medicine -- Chapter 2. Biological activities of nanoparticles and mechanism of action -- Chapter 3. Application of nanoparticles in Drug delivery -- Chapter 4. Antimicrobial activity of metallic nanoparticles using prokaryotic model organisms -- Chapter 5. Modelling nanoparticles parameters for antibacterial activities -- Chapter 6. Saccharomyces cerevisiae as model organism to study biological activities of nanoparticles -- Chapter 7. Investigation of Biological activities of Nanoparticles using Cell Lines -- Chapter 8. Caenorhabditis elegans: a model organism to decipher biological activities of nanoparticles -- Chapter 9. Zebra fish model system to investigate biological activities of nanoparticles -- Chapter 10. Drosophila melanogaster - A model organism to understand biological activities of nanoparticles -- Chapter 11. Understanding the biological activities of nanoparticles using murine models -- Chapter 12. Insecticidal activity nanoparticles and mechanism of action -- Chapter 13. Routes of Exposures and Toxicity of Nanoparticles -- Chapter 14. Toxicological evaluation of nanoparticles using prokaryotic model organisms -- Chapter 15. Evaluation of Toxicity Nanoparticles using Cell lines -- Chapter 16. Saccharomyces cerevisiae : Model organism to evaluate nanoparticles toxicity -- Chapter 17. Caenorhabditis elegans: Evaluation of nanoparticle toxicity -- Chapter 18. Zebra fish: A laboratory model to evaluate Nanoparticle Toxicity -- Chapter 19. Evaluation of toxicity of nanoparticles using Brine Shrimp -- Chapter 20. Drosophila Model to Decipher the Toxicity of Nanoparticles -- Chapter 21. Murine models to understand the toxicity of nanoparticles -- Chapter 22. Challenges and future perspectives of Nanotoxicology.
    Abstract: This book provides a comprehensive overview of state-of-the-art applications of nanotechnology in biology and medicine, as well as model organisms that can help us understand the biological activity and associated toxicity of nanoparticles, and devise strategies to minimize toxicity and enhance therapies. Thanks to their high surface-to-volume ratio, nanoparticles are characterized by excellent biocompatibility and bioavailability, a high therapeutic index, and relatively low toxicity, which has led to their widespread application in the early diagnosis of diseases, comprehensive monitoring of disease progression, and improved therapeutics. The book also explores nanoparticle-based insecticides and their mechanisms of action, and provides a comparative analysis of the various model organisms that are used to understand the biological properties of nanoparticles. Further, it describes various in-vivo models that yield important insights into nanomaterial-mediated toxicity, promoting the optimal utilization of nanoparticles. In closing, the book discusses future perspectives and regulatory issues concerning the use of nanomaterials in translational research.
    Type of Medium: Online Resource
    Pages: XIII, 466 p. 64 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811517020
    URL: https://doi.org/10.1007/978-981-15-1702-0
    DOI: 10.1007/978-981-15-1702-0
    DDC: 615
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    Computer-Aided Drug Design (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Bioinformatics. ; Proteins. ; Pharmacology. ; Computational and Systems Biology. ; Proteins.
    Description / Table of Contents: 1 Computational Approaches in Drug Discovery and Design -- 2 Molecular Modeling of Proteins: Methods, Recent Advances and Future Prospects -- 3 Cavity/Binding Site Prediction Approaches, and their Applications -- 4 Role of ADMET Tools in Current Scenario; Application and Limitations -- 5 Database Resources for Drug Discovery -- 6 Molecular Docking and Structure-Based Drug Design -- 7 Molecular Dynamics Simulation of Protein and Protein-Ligand Complexes -- 8 Computational Approaches for Drug Target Identification -- 9 Computational Screening Techniques for Lead Design and Development -- 10 Advances in Pharmacophore Modeling and its Role in Drug Designing -- 11 In Silico Designing of Vaccines: Methods, Tools and Their Limitations -- 12 Machine learning Approaches to Rational Drug Design. .
    Abstract: This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.
    Type of Medium: Online Resource
    Pages: XIII, 306 p. 80 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811568152
    URL: https://doi.org/10.1007/978-981-15-6815-2
    DOI: 10.1007/978-981-15-6815-2
    DDC: 615
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    Circadian Pharmacokinetics (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Pharmacology. ; Pharmacy. ; Medical sciences. ; Drug development. ; Pharmacology. ; Pharmacy. ; Preclinical Research.
    Description / Table of Contents: Chapter 1. Introduction to mammalian circadian clock system -- Chapter 2. Introduction to pharmacokinetics -- Chapter 3. Circadian clock and metabolic diseases -- Chapter 4. Circadian clock and CYP metabolism -- Chapter 5. Circadian clock and non-CYP phase I metabolism -- Chapter 6. Circadian clock and phase II metabolism -- Chapter 7. Circadian clock and uptake transporters -- Chapter 8. Circadian clock and efflux transporters -- Chapter 9. Role of pharmacokinetics in chronotherapeutics -- Chapter 10. Role of non-pharmacokinetic factors in chronoefficacy.
    Abstract: This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
    Type of Medium: Online Resource
    Pages: VII, 253 p. 59 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811588075
    URL: https://doi.org/10.1007/978-981-15-8807-5
    DOI: 10.1007/978-981-15-8807-5
    DDC: 615
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    Good Research Practice in Non-Clinical Pharmacology and Biomedicine (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Neurosciences. ; Cardiology. ; Oncology. ; Pharmacology. ; Neuroscience. ; Cardiology. ; Oncology.
    Description / Table of Contents: 1. Quality in Non-GxP Research Environment -- 2. Guidelines & Initiatives for Good Research Practice -- 3. Learning from principles of evidence-based medicine to optimize nonclinical research practices -- 4. General Principles of Preclinical Study Design -- 5. Resolving the tension between exploration and confirmation in preclinical biomedical research -- 6. Blinding and Randomization -- 7. Out of control? Managing baseline variability in experimental studies with control groups -- 8. Quality of Research Tools -- 9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies -- 10. Building robustness intro translational research -- 11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research -- 12. Minimum Information in In Vivo Research -- 13. A reckless guide to P-values: Local evidence, global errors -- 14. Electronic Lab Notebooks and Experimental Design Assistants -- 15. Data storage -- 16. Design of meta-analysis studies -- 17. Publishers’ responsibilities in promoting data quality and reproducibility -- 18. Quality governance in biomedical research -- 19. Good Research Practice – Lessons from Animal Care & Use -- 20. Research collaborations and quality in research: foes or friends? -- 21. Costs of implementing quality in research practice.
    Abstract: This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
    Type of Medium: Online Resource
    Pages: X, 423 p. 34 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030336561
    Series Statement: Handbook of Experimental Pharmacology, 257
    URL: https://doi.org/10.1007/978-3-030-33656-1
    DOI: 10.1007/978-3-030-33656-1
    DDC: 615
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    Substance Use Disorders : From Etiology to Treatment (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Pharmacology.
    Description / Table of Contents: 1. Methods for Population Research on Substance Use and Consequences -- 2. Translational Molecular Approaches in Substance Abuse Research -- 3. Small Molecule Neuropeptide-S and Melanocortin Receptor Ligands As Potential Treatments for Substance Use Disorders -- 4. Emerging Insights into Mu Opioid Pharmacology -- 5. Behavioral Pharmacology of Drugs Acting at Mu Opioid Receptors -- 6. The Rise and Fall of Kappa-Opioid Receptors in Drug Abuse Research -- 7. Clinical Trials for Opioid Use Disorder -- 8. Modelling Differential Vulnerability to Substance Use Disorder in Rodents: Neurobiological Mechanisms -- 9. Activity-Dependent Epigenetic Remodeling in Cocaine Use Disorder -- 10. Molecular Mechanisms of Amphetamines -- 11. Clinical Trials for Stimulant Use Disorders: Addressing Heterogeneities That May Undermine Treatment Outcomes -- 12. Molecular Mechanism and Cannabinoid Pharmacology -- 13. Pharmacotherapies for Cannabis Use Disorders: Clinical Challenges and Promising Therapeutic Agents -- 14. Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence -- 15. Randomized Clinical Trials Investigating Innovative Interventions for Smoking Cessation in the Last Decade -- 16. Adolescent Vulnerability to Alcohol Use Disorder: Neurophysiological Mechanisms from Preclinical Studies -- 17. Medication Development for Alcohol Use Disorder: A Focus on Clinical Studies -- 18. Newly Emerging Drugs of Abuse.
    Abstract: The purpose of this book is to provide a broad scope of substance use disorder research and how these findings can impact treatment outcomes. The research and outcomes described in this book represent important principles related to identifying and understanding factors related to substance use disorders. The first section is dedicated to methodology including population-based surveys, basic neuroanatomy, chemistry, molecular biology, behavioral models and brain imaging. The second section utilizes this methodology in research related to opioids, cocaine, marijuana, alcohol and nicotine. The book is aimed at both professionals (academics, clinicians, practitioners) and students or trainees.
    Type of Medium: Online Resource
    Pages: X, 502 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030336790
    Series Statement: Handbook of Experimental Pharmacology, 258
    URL: https://doi.org/10.1007/978-3-030-33679-0
    DOI: 10.1007/978-3-030-33679-0
    DDC: 615
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    Interaction of Nanomaterials with the Immune System (2020)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Immunology. ; Nanotechnology. ; Pharmacology. ; Immunology. ; Nanotechnology.
    Description / Table of Contents: Overview of immune response to nanomaterials caused by either inhalation, oral, or dermal exposure -- Engineered nanomaterials: synthesis, characterization, uses and exposure -- Impact of nanomaterials on barrier function -- Complement activation and inflammation -- Macrophage function and phagocytosis -- Mast cells -- Impact on dendritic cell - lymphocyte function -- Impact on host pathogen response and microbiome -- Allergy/autoimmunity -- Pre-existing allergic or bacterial-induced lung disease -- Nanomaterial effects on viral infection -- Immunotoxicity and carcinogenesis -- In vivo animal models (nude mice, transgenic models) -- In vitro cell culture models -- In silico computational modeling -- Summary of mechanisms of immune modulation. .
    Abstract: This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs. .
    Type of Medium: Online Resource
    Pages: X, 223 p. 16 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030339623
    Series Statement: Molecular and Integrative Toxicology,
    URL: https://doi.org/10.1007/978-3-030-33962-3
    DOI: 10.1007/978-3-030-33962-3
    DDC: 615
    Language: English
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    Bone Regulators and Osteoporosis Therapy (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Cytology. ; Cytokines. ; Diseases. ; Proteins. ; Endocrinology. ; Pharmacology. ; Cell Biology. ; Cytokines and Growth Factors. ; Diseases. ; Proteins. ; Endocrinology.
    Description / Table of Contents: The cells of bone their interactions -- Parathyroid hormone and bone -- Vitamin D and bone -- Gonadal hormones and bone -- Thyroid hormones, glucocorticoids, insulin, and bone -- Growth factors and bone -- Prostaglandins and bone -- Cytokines and bone: osteoimmunology -- Chemokines and bone -- Calcium and bone -- FGF-23 and bone and mineral metabolism -- Nervous system mediators and bone -- Genetics of bone disorders -- Osteoporosis pathogenesis -- Structural and metabolic assessment of bone status -- Osteoporosis Therapeutics 2019 -- New targets and emergent therapies for osteoporosis -- Drugs causing bone loss -- Natural Products as potential bone therapies.
    Abstract: This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the cells of bone and their interactions. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines. Topics that have commanded particular attention recently are calcium, FGF-23, nervous system bone interactions. Drugs that cause bone loss provide important information on mechanism as well as therapeutic considerations. An overview of the genetics of bone disorders and a discussion of the pathophysiology of osteoporosis establish the clinical context. The final chapters discuss current and potential osteoporosis treatments. .
    Type of Medium: Online Resource
    Pages: X, 518 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030573782
    Series Statement: Handbook of Experimental Pharmacology, 262
    URL: https://doi.org/10.1007/978-3-030-57378-2
    DOI: 10.1007/978-3-030-57378-2
    DDC: 615
    Language: English
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    Forest-Water Interactions (2020)
    Cham :Springer International Publishing :
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    Keywords: Physical geography. ; Forestry. ; Water. ; Hydrology. ; Botanical chemistry. ; Geology. ; Physical Geography. ; Forestry. ; Water. ; Earth System Sciences. ; Plant Biochemistry. ; Geology.
    Description / Table of Contents: Chapter 1. Cracking “Open” Technology in Ecohydrology -- Chapter 2. The Necessity of Sensor Calibration for the Precise Measurement of Water Fluxes in Forest Ecosystems -- Chapter 3. Applications of Unpiloted Aerial Vehicles (UAVs) in Forest Hydrology -- Chapter 4. LiDAR Applications to Forest-Water Interactions -- Chapter 5. On Complementing the Tracer Toolbox for Quantifying Hydrological Connectivity: Insights Gained from Terrestrial Diatom Tracer Experiments -- Chapter 6. Lessons in New Measurement Technologies: From Instrumenting Trees to the Trans-African Hydro-Meteorological Observatory -- Chapter 7. Primary Steps in Analyzing Data – Tasks and Tools for a Systematic Data Exploration -- Chapter 8. Martin Zwanzig, Robert Schlicht, Nico Frischbier, and Uta Berger -- Chapter 8 Spatiotemporal Statistics: Analysis of Spatially and Temporally-Correlated Throughfall Data – Exploring and Considering Dependency and Heterogeneity -- Chapter 9. Analysis of Vegetation-Water Interactions: Application and Comparison of Maximum-Likelihood Estimation and Bayesian Inference -- Chapter 10. Machine Learning Applications in Hydrology -- Chapter 11. Advances and Future Research Directions in the Study of Leaf Water Repellency -- Chapter 12. Throughfall Erosivity in Relation to Drop Size and Crown Position: A Case Study from a Teak Plantation in Thailand -- Chapter 13. Assessing the Ecological Significance of Throughfall in Forest Ecosystems -- Chapter 14. Root-Water Relations and Interactions in Mixed Forest Settings -- Chapter 15. Effects of Stemflow on Soil Water Dynamics in Forest Stands -- Chapter 16. Radiocesium Cycling in the Context of Forest-Water Interactions -- Chapter 17. Urban Trees as Green Infrastructure for Stormwater Mitigation and Use -- Chapter 18. Urban Tree Canopy Effects on Water Quality via Inputs to the Urban Ground Surface -- Chapter 19. Modeling the Impact of Urban Trees on Hydrology -- Chapter 20. Using Community Planning to Conserve Green Infrastructure and Water Quality -- Chapter 21. Forest Influences on Streamflow: Case Studies from the Tatsunokuchi-Yama Experimental Watershed, Japan and the Leading Ridge Experimental Watershed, USA -- Chapter 22. The Biogeochemical Response of Nitrate and Potassium to Landscape Disturbance in Watersheds of the Hubbard Brook Experimental Forest, New Hampshire, USA -- Chapter 23. Water and Nutrient Budgets of Organic Layers and Mineral Topsoils under Tropical Montane Forest in Ecuador in Response to 15 Years of Environmental Change -- Chapter 24. Forest-Water Interactions under Global Change.
    Abstract: The United Nations has declared 2018-2028 as the International Decade for Action on Water for Sustainable Development. This is a timely designation. In an increasingly thirsty world, the subject of forest-water interactions is of critical importance to the achievement of sustainability goals. The central underlying tenet of this book is that the hydrologic community can conduct better science and make a more meaningful impact to the world’s water crisis if scientists are: (1) better equipped to utilize new methods and harness big data from either or both high-frequency sensors and long-term research watersheds; and (2) aware of new developments in our process-based understanding of the hydrological cycle in both natural and urban settings. Accordingly, this forward-looking book delves into forest-water interactions from multiple methodological, statistical, and process-based perspectives (with some chapters featuring data sets and open-source R code), concluding with a chapter on future forest hydrology under global change. Thus, this book describes the opportunities of convergence in high-frequency sensing, big data, and open source software to catalyze more comprehensive understanding of forest-water interactions. The book will be of interest to researchers, graduate students, and advanced undergraduates in an array of disciplines, including hydrology, forestry, ecology, botany, and environmental engineering. The chapter “Cracking “Open” Technology in Ecohydrology” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XV, 628 p. 124 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030260866
    Series Statement: Ecological Studies, Analysis and Synthesis, 240
    URL: https://doi.org/10.1007/978-3-030-26086-6
    DOI: 10.1007/978-3-030-26086-6
    DDC: 910.02
    Language: English
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  • 78
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    Landscape Patterns in a Range of Spatio-Temporal Scales (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Landscape ecology. ; Biogeography. ; Physical Geography. ; Landscape Ecology. ; Biogeosciences. ; Earth System Sciences.
    Description / Table of Contents: Part I. Theory of Landscape Pattern and Hierarchy -- Chapter 1. Concepts of Landscape Pattern (Alexander V. Khoroshev) -- Chapter 2. Polygeosystem Fundamentals of Landscape Science (Alexander K. Cherkashin) -- Chapter 3. Multi-pattern (Polystructural) Organization of a Landscape - Geophysical Approach (Vladislav V. Sysuev) -- Part II. How Patterns Indicate Actual Processes -- Chapter 4. Representation of Process Development Laws in Morphological Pattern Laws: Approach of the Mathematical Morphology of Landscape (Alexey S. Victorov) -- Chapter 5. Transformation of the Chernobyl 137Cs Contamination Patterns at the Microlandscape Level as an Indicator of Stochastic Landscape Organization (Vitaly G. Linnik) -- Chapter 6. Determination of the Order Parameters of The Landscape at the Regional Level (Mikhail Yu. Puzachenko) -- Chapter 7. Land Cover Thermodynamic Characteristics Defined by Remote Multispectal Data Based on Non-Extensive Statistical Mechanics (Robert B. Sandlersky) -- Part III How Patterns Control Actual Processes -- Chapter 8. Structure and Phytomass Production of Coastal Geosystems Near Lake Baikal (Yuliya V. Vanteeva) -- Chapter 9. Catena Patterns as a Reflection of Landscape Internal Heterogeneity (Irina A. Avessalomova) -- Chapter 10. Structure of Topogeochores and Modern Landscape-Geochemical Processes (Yury M. Semyonov) -- Chapter 11. Modeling of Hydrological and Climatic Resources of a Landscape for Sustainable Land Use at Small Watersheds (Alexander A. Yerofeev) -- Chapter 12. Influence of the Landscape Structure of Watersheds on the Processes of Surface Water Quality Formation (Case Study of Western Siberia) (Vitaly Yu. Khoroshavin) -- Chapter 13. Comparison of Landscape and Floristic Diversity in Plain Catchments at the Level of Elementary Regions (Dmitry V. Zolotov) -- Part IV. How Patterns Indicate Genesis and Influence Future Evolution Trends -- Chapter 14. Altitudinal Landscape Complexes of the Central Russian Forest-Steppe (Anatoly S. Gorbunov) -- Chapter 15. Landscape Structure as Indicator of Debris Flow and Avalanche Activity in the Russian Caucasus Mountains (Marina N. Petrushina) -- Chapter 16. Multiscale Analysis of Landscape Structure (Alexander V. Khoroshev) -- Part V. How Patterns Control Dynamic Events -- Chapter 17. Structure and Long-Term Dynamics of Landscape as a Reflection of the Natural Processes and History of Nature Use: the Example of the Northwestern European Russia (Grigorii A. Isachenko) -- Chapter 18. Seasonal Dynamics in the Context of Polystructural Organization of Landscapes (on the Example of Sverdlovsk Region) (Olga Yu. Gurevskikh) -- Part VI. How Patterns Respond to Climatic and Anthropogenic Changes -- Chapter 19. Dendrochronological Indication of Landscape Spatio-Temporal Organization in the Northern Taiga of West Siberian Plain and Elbrus Region: Astrophysical and Geophysical Drivers of Bioproductivity (Kirill N. Dyakonov) -- Chapter 20. Carbon Balance in Forest Ecosystems and Biotic Regulation of Carbon Cycle Under Global Climate Changes (Erland G. Kolomyts) -- Chapter 21. Actual Changes of Mountainous Landscapes in Inner Asia as a Result of Anthropogenic Effects (Kirill V. Chistyakov) -- Part VII. How Landscape Patterns Affected Land Use in the Past -- Chapter 22. Initial Stages of Anthropogenic Evolution of Landscapes in Russia (Viacheslav A. Nizovtsev) -- Chapter 23. How Natural and Positional Factors Influence Land-Use Change During Last 250 Years in Temperate Russia (Victor M. Matasov) -- Chapter 24. Landscape Features of the Prehistory of Moscow (Viacheslav A. Nizovtsev) -- Chapter 25. GIS-Based Study of Landscape Structure and Land Use Within the River Valleys in the Southern Tomsk Region: Spatial-Temporal Aspects (Vadim V. Khromykh) -- Part VIII. How Landscape Patterns Determine Actual Land Use -- Chapter 26. The Development of Territorial Planning and Agrolandscapes Projecting in Russia (Valery I. Kiryushin) -- Glossary.
    Abstract: This book presents the polycentric and multiscale view of landscape which has been developed in Russia within a framework of physical geography since the early twentieth century. The authors develop the ideas of hierarchical organization of a landscape and strong relationships between abiotic and biotic components with equal attention to both vertical fluxes and lateral transfer. Three-dimensional representation of landscape involves strong emphasis on abiotic drivers of pattern development including relief, geological structures and runoff. The objective of this book is to demonstrate the multiplicity of models and multiscale approach to description and explanation of landscape pattern, functioning, dynamics, and evolution. The contributions deal with various hierarchical levels ranging from within-unit interior variability to between-units interaction at landscape level, as well as regional and supra-regional zonal patterns. Divided into 8 clear parts, the 28 chapters treat spatial pattern in one of the following aspects: indicator of actual matter and energy flows control over actual processes including disturbance expansion as well as determinant of future development indicator of genesis and prerequisite for future trends driver for short-term dynamics of processes response to climatic and anthropogenic influences factor of settlement network and land use adaptation at various historical epochs framework for actual land use spatial arrangement. This contributed volume is written for researchers and students in the field of landscape ecology, physical geography, environmental impact assessment, and ecological planning.
    Type of Medium: Online Resource
    Pages: XXXIII, 439 p. 159 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030311858
    Series Statement: Landscape Series, 26
    URL: https://doi.org/10.1007/978-3-030-31185-8
    DOI: 10.1007/978-3-030-31185-8
    DDC: 910.02
    Language: English
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    Palaeohydrology : Traces, Tracks and Trails of Extreme Events (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Water. ; Hydrology. ; Geology. ; Natural disasters. ; Human geography. ; Physical Geography. ; Water. ; Geology. ; Natural Hazards. ; Human Geography.
    Description / Table of Contents: Part A: Studies with temporal focus -- Ch.1 Global megaflood paleohydrology -- Ch.2 Flooding northern Germany: impacts and magnitudes of Middle Pleistocene glacial lake-outburst floods -- Ch.3 Outburst flood from Möhne Reservoir in May 1943 after aerial bombing -- Part B: Studies with regional focus -- Ch.4 Droughts in historical times in Europe, as derived from documentary evidence -- Ch.5 Geomorphological and geoarchaeological evidence of the Medieval deluge in the Tagliamento River (NE Italy) -- Ch.6 Inverted channels in the eastern Sahara – distribution, formation, and interpretation to enable reconstruction of paleodrainage networks -- Ch.7 Noah’s Flood – probing an ancient narrative using geoscience -- Part C: Studies with methodical and technical topics -- Ch.8 Luminescence dating in fluvial settings: overcoming the challenge of partial bleaching -- Ch.9 Large palaeomeanders in Europe: distribution, formation process, age, environments and significance -- Ch.10 Palaeostage indicators in rivers - an illustrated review -- Ch.11 High-resolution sedimentary paleoflood records in alluvial river environments - a review of recent methodological advances and application to flood hazard assessment.
    Abstract: The book provides a review of the most relevant topics on the booming discipline of palaeohydrology and focuses on previous extreme events like exceptional floods and droughts. Reviews written by leading experts of their fields are combined with selected key studies and presentations on up-to-day methodical and conceptional topics as a perspective for further research. Consequently, the compilation provides an excellent review on the state of the art of numerous relevant topics of palaeohydrology and acts as unique introduction for early career scientists and scientists of different disciplines working on hydrological extreme events, both in basic research and applied aspects. .
    Type of Medium: Online Resource
    Pages: X, 230 p. 110 illus., 93 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030233150
    Series Statement: Geography of the Physical Environment,
    URL: https://doi.org/10.1007/978-3-030-23315-0
    DOI: 10.1007/978-3-030-23315-0
    DDC: 910.02
    Language: English
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    Remote Sensing Monitoring and Evaluation of Degraded Grassland in China : Accounting of Grassland Carbon Source and Carbon Sink (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Physical geography. ; Biotic communities. ; Sustainability. ; Geographic information systems. ; Physical Geography. ; Ecosystems. ; Sustainability. ; Geographical Information System.
    Description / Table of Contents: Research progress of the grassland carbon cycle and grassland degradation in China -- Grassland coverage inter-annual variations and its coupling relation with hydrothermal factors in China -- Spatial-temporary dynamics of grassland net primary productivity in China and its response to climate factors -- Inter-annual variation in grassland net ecosystem productivity and its coupling relation to climatic factors in China -- The variation of landscape and NPP of main pastoral grasslands in China -- Grassland degradation remote sensing monitoring and driving factors quantitative assessment in China from 1982 to 2010 -- Grassland degradation restoration and constructing green ecological protective screen.
    Abstract: This book focuses on grassland ecosystem evaluation including vegetation coverage, net primary productivity, carbon sink accounting, and grassland degradation evaluation based on mutual data resource, ecosystem model simulation, remote sensing monitoring and driving mechanism exploration. It aims to provide a guide seeking to understand the overall situation of grassland in China in the context of global climate change and build a scenario for the driving force quantitative evaluation. It will be an essential reference to the terrestrial ecosystem carbon cycle and degraded grassland ecological restoration engineer implementation. Chapters are carefully developed to cover (1) situation of grassland in China; (2) spatial-temporal of grassland coverage in China;(3) net primary productivity evaluation; (4) carbon sink/source accounting and its carbon-hydrology effect;(5) grassland landscape pattern; (6) grassland degradation evaluation based on remote sensing;(7) Grassland degradation restoration and constructing green ecological protective screen. The new scenario and driving mechanism evaluation model make this book a valuable read for researcher of land ecosystem carbon cycle, ecosytem degradation remoete sensing evalution as well as organizations engaged in eco-restoration practices.
    Type of Medium: Online Resource
    Pages: VIII, 138 p. 49 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813293823
    Series Statement: Springer Geography,
    URL: https://doi.org/10.1007/978-981-32-9382-3
    DOI: 10.1007/978-981-32-9382-3
    DDC: 910.02
    Language: English
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    KULUNDA: Climate Smart Agriculture : South Siberian Agro-steppe as Pioneering Region for Sustainable Land Use (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Climatology. ; Agriculture Economic aspects. ; Agriculture. ; Soil science. ; Physical Geography. ; Climate Sciences. ; Earth System Sciences. ; Agricultural Economics. ; Agriculture. ; Soil Science.
    Description / Table of Contents: Foreword -- Chapter 1: Background to the natural landscape and the consequences of the ecosystem conversion -- Chapter 2: Socio-economic and institutional drivers and impacts of land use change -- Chapter 3: Potentials and Strategies of adapted land use as basis for ecological and social-economic sustainable development of the rural landscape -- Chapter 4: Change in Regional Development -- Chapter 5: Summary and outlook -- Acknowledgement.
    Abstract: This book focuses on a representative example and one of the world’s largest steppe conversions, and provides a detailed overview of the results of the BMBF-funded research project KULUNDA. As part of the Siberian virgin land policy, the Kulunda steppe was transformed into agricultural land from 1954 to 1965. In the course of the project, a multidisciplinary research team conducted a natural, social-economic and agro-scientific cause-and-effect analysis of (agro-)ecosystem destabilisation, as well as various field trials covering tillage and crop rotation options in their socio-economic context. The ecologically and economically sound findings offer strategies for combining climate smart land utilization, ecosystem restoration and sustainable regional development, and can readily be applied to other virgin land conversion efforts. In addition, the findings on the Eurasian steppes will expand the current conversion literature, which mainly consists of the ‘Dust Bowl’ literature of the North American plains. Given its scope, the book will appeal to scientists, professionals, and students in the environmental, geo- and climate sciences. .
    Type of Medium: Online Resource
    Pages: XXVI, 522 p. 202 illus., 164 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030159276
    Series Statement: Innovations in Landscape Research,
    URL: https://doi.org/10.1007/978-3-030-15927-6
    DOI: 10.1007/978-3-030-15927-6
    DDC: 910.02
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    Governance of Arctic Shipping : Rethinking Risk, Human Impacts and Regulation (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Climatology. ; Water. ; Hydrology. ; Environmental management. ; Freshwater ecology. ; Marine ecology. ; Physical Geography. ; Climate Sciences. ; Water. ; Environmental Management. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Introduction -- PART A: MARINE RISK ASSESSMENT PERSPECTIVES -- 1) Application of the IGRC framework for SAR -- 2) Historical Maritime Search and Rescue (SAR) Incident Analysis: Interactive visualization aids for improved risk assessment and decision making -- 3) Oil spill risk in the Canadian Arctic: An exploratory application of the International Risk Governance Framework -- 4) Ship-generated underwater noise -- PART B: INDIGENOUS RIGHTS AND MARINE SPATIAL PLANNING PERSPECTIVES -- 5) Shipping Governance and Inuit Rights -- 6) Inuit knowledge and data: An exploration of decision support systems for marine spatial planning in the eastern Canadian Arctic -- 7) Balancing competing ocean uses: The EU approach to Marine Spatial Planning -- 8) Integrated Ocean Management in France: Some perspectives -- PART C: MARITIME REGULATORY POLICY PERSPECTIVES -- 9) The IMO Framework and Process of Shipping Regulations -- 10) The regulation of air pollution from ships in the Northwest Atlantic and Arctic Oceans: The need for an integrated and equitable approach -- 11) A Change in the Ice Regime: Polar Code Implementation in Canada Drummond Fraser, Transport Canada -- 12) Seafarers and Arctic cruise shipping: Protecting those who work while others explore and sightsee -- 13) Mapping the Occupational Health and Safety Challenges Arising from Employment-Related Geographical Mobility (E-RGM) Among Canadian Seafarers on the Great Lakes and St Lawrence River -- 14) Fisher safety -- 15) Search and rescue at sea: do new challenges need new rules? -- 16) Conclusion. .
    Abstract: This open access book is a result of the Dalhousie-led research project Safe Navigation and Environment Protection, supported by a grant from the Ocean Frontier Institute’s the Canada First Research Excellent Fund (CFREF). The book focuses on Arctic shipping and investigates how ocean change and anthropogenic impacts affect our understanding of risk, policy, management and regulation for safe navigation, environment protection, conflict management between ocean uses, and protection of Indigenous peoples’ interests. A rapidly changing Arctic as a result of climate change and ice loss is rendering the North more accessible, providing new opportunities while producing impacts on the Arctic. The book explores ideas for enhanced governance of Arctic shipping through risk-based planning, marine spatial planning and scaling up shipping standards for safety, environment protection and public health. .
    Type of Medium: Online Resource
    Pages: XIV, 319 p. 40 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030449759
    Series Statement: Springer Polar Sciences,
    URL: https://doi.org/10.1007/978-3-030-44975-9
    DOI: 10.1007/978-3-030-44975-9
    DDC: 910.02
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    Himalaya on the Threshold of Change (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Climatology. ; Human geography. ; Economic geography. ; Cultural geography. ; Natural disasters. ; Physical Geography. ; Climate Sciences. ; Human Geography. ; Economic Geography. ; Social and Cultural Geography. ; Natural Hazards.
    Description / Table of Contents: Introduction -- Natural Aspects -- Chapter 1 -- Geography and Geology -- Chapter 2 -- The Climate of the Uttarakhand Himalaya -- Chapter 3 -- Glaciers of the Uttarakhand Himalaya -- Chapter 4 -- Water Resources and Change -- Chapter 5 -- Forests of Uttarakhand Himalaya -- Chapter 6 -- Increasing Events of Disasters -- Chapter 7 -- Change in Culture and Customs -- Chapter 8 -- Population, Social and Economic Change -- Chapter 9 -- Migration and Agrarian Change -- Chapter 10 -- Sustainable Development under Changing Environment -- Chapter 11 -- Conclusions: Drivers of Change, Resilience and Adaptation -- Index.
    Abstract: This book provides a unique and comprehensive assessment of the changes that have been taking place in the Himalayas. It describes in detail all the aspects of change, both natural and cultural, along with their implications, and suggests policy measures to help mitigate them. The book is divided into two major sections – on natural changes and cultural changes – and 11 chapters: an introduction, six addressing changes that concern natural aspects, and four exploring cultural changes and presenting the book’s conclusions. The content is based on a study conducted using a participatory observation/empirical method. Time series data from secondary sources is also included, helping to analyze the various changes. The findings are presented in the form of color graphs, models, maps, photographs, and tables. The book offers a valuable resource for policymakers, and will prove equally useful for all other stakeholders, e.g. researchers, students and development agents. .
    Type of Medium: Online Resource
    Pages: XXXVII, 193 p. 73 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030141806
    Series Statement: Advances in Global Change Research, 66
    URL: https://doi.org/10.1007/978-3-030-14180-6
    DOI: 10.1007/978-3-030-14180-6
    DDC: 910.02
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    Large Asian Lakes in a Changing World : Natural State and Human Impact (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Physical geography. ; Water. ; Hydrology. ; Archaeology. ; Geology. ; Physical Geography. ; Water. ; Archaeology. ; Geology.
    Description / Table of Contents: The Dead Sea and Its Deviation from Natural Conditions -- Lake Sevan: Evolution, Biotic Variability and Ecological Degradation -- Past and Current Changes in the Largest Lake of the World: The Caspian Sea -- The Aral Sea: A Story of Devastation and Partial Recovery of a Large Lake -- Geological History and Present Conditions of Lake Balkhash -- Lake Issyk-Kul: Its History and Present State -- Lop Nur in NW China: Its Natural State, and a Long history of Human Impact -- Uvs Nuur: A Sentinel for Climate Change in Eastern Central Asia. .
    Abstract: Describing the natural state of eight important lakes in Asia and the human impact on these lake ecosystems, this book offers a valuable reference guide. Over the past several decades the Aral Sea, Dead Sea, Lake Balkhash and other major lakes in Asia have undergone significant changes with regard to their size, water level, chemical composition, and flora and fauna. Most of these changes resulted from the loss of water from tributaries (now used for irrigation farming) or increasing consumption in local industries and households. However, significant human impacts may have begun as early as 2000 years ago. In addition to the three lakes mentioned above, Lake Sevan (Armenia), the Caspian Sea (Azerbaijan, Iran, Kazakhstan, Russia, Turkmenistan), Lake Issyk-Kul (Kyrgyzstan), and Lake Lop Nur (China) are discussed as the most prominent examples of changing lake ecosystems. In contrast, an example of an almost pristine lake ecosystem is included with the report on Lake Uvs Nuur (Mongolia). For each lake, the book summarizes its origin and early geological history, and reconstructs its natural state and variability on the basis of proxy records from drilled or exposed lake sediments that have accumulated since the last ice age. The frequently observed reductions in lake level and size during most recent decades led often to significant environmental impacts in the respective lake catchments including vegetation deterioration, soil erosion and badland formation, soil salinization or the formation of sinkholes. .
    Type of Medium: Online Resource
    Pages: IX, 264 p. 59 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030422547
    Series Statement: Springer Water,
    URL: https://doi.org/10.1007/978-3-030-42254-7
    DOI: 10.1007/978-3-030-42254-7
    DDC: 910.02
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    Impacts of Climate and Human Activities on Water Resources and Quality : Integrated Regional Assessment (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Physical geography. ; Climatology. ; Environment. ; Physical Geography. ; Climate Sciences. ; Environmental Sciences.
    Description / Table of Contents: Introduction -- Extreme Precipitation Events, Floods and Associated Socio-economic Damages in China in Recent Decades -- Changes of Water Quality in the Yangtze River Basin -- Spatiotemporal Evaluation of Water Quality and Water Quality Incidents over Japan -- Assessment of Precipitation Amounts and Climate Extremes in Japan -- Precipitation Changes in Hokkaido and Future Water Resources in Its Main Rivers -- Estimation of Nutrient and Suspended Sediment Loads in the Ishikari River -- The Aral Sea Basin Crisis and Future Water- Climate- Food Nexus in Turkmenistan.
    Abstract: With the rapid increase of world population, the global water shortage is set to be the major crises of the twenty-first century; that is, population dynamics (growth, age distribution, urbanization and migration) create pressures on freshwater resources due to the increased water demands and pollution. Moreover, water resources management faces a new uncertainty- i.e. the potential for longer-term and more persistent climate change nowadays, which, in coming years, may significantly affect the availability of supply and patterns of water demand. This book mainly focuses on the impact of climate change and human activities on water quality and water resources in Asia Countries. It begins by describing the characteristics of water related disasters in the world. Then, the book analyzes the changes of floods and associated socio-economic damages for whole China over the last century, and assesses water quality and pollution source for the Yangtze River Basin, suggesting water-related disasters would become more intense, longer lasting, and/or more frequent in a future warmer climate. Then, after investigating spatiotemporal trends and causes of water quality and water quality incidents (Chapter 4) and precipitation extreme events (Chapter 5) in Japan, subsequent two chapters mainly evaluate the climate and human impacts on precipitation variations, water quality and water resources in the Hokkaido area. The final chapter comprehensively analyzes climate change impacts on water resources in the Aral Sea Basin, and then estimate the water requirements and water deficits for irrigation, future agricultural yields of seven major crops, and land and water productivity in four provinces of Turkmenistan considering climate change, population growth, and three socio-economic development scenarios. All results obtained from this book may provide a means to reduce water quality incidents and mitigate future negative impacts by adapting water management. Furthermore, the improved methods for water quality modeling in data scarce regions are transferable to other study areas and applicable in future research.
    Type of Medium: Online Resource
    Pages: XIV, 183 p. 103 illus., 102 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811393945
    URL: https://doi.org/10.1007/978-981-13-9394-5
    DOI: 10.1007/978-981-13-9394-5
    DDC: 910.02
    Language: English
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