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  • 1
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Cardiology. ; Therapeutics. ; Heart Surgery. ; Pharmacology. ; Cardiology. ; Therapeutics. ; Cardiac Surgery.
    Description / Table of Contents: Coronary Artery Disease: From Mechanism to Clinical Practice -- Evidence in guidelines for treatment of coronary artery disease -- Revascularization For Coronary Artery Disease: Principle And Challenges -- Antithrombotic drugs: pharmacology and perspectives -- Lipid modifying drugs: pharmacology and perspectives -- Anti-hypertensive drugs: pharmacology and perspectives -- Pharmaceutical treatment for Heart failure -- Drug discovery for coronary artery disease.
    Abstract: This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.
    Type of Medium: Online Resource
    Pages: IX, 339 p. 7 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811525179
    Series Statement: Advances in Experimental Medicine and Biology, 1177
    DDC: 615
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Pediatrics. ; Pharmacology. ; Pediatrics.
    Description / Table of Contents: Anti-epileptic drugs in pediatrics -- Current and new therapies for Duchenne Muscular Dystrophy -- Lysosomal diseases -- Mitochondriopathies -- Endocrinology thyroid, pituitary, growth stimulant, growth reduction -- Bone disease – bisphosphonates -- Diabetes type 1 and 3 (insulin; sulfonylurea; others) -- Diabetes type 2 (metformin etc.) -- Dermatology – part 1 urticaria, atopic dermatitis -- Dermatology part 2, ichtyosis, psoriasis -- Cardiovascular part 1- catcholamines, inotropic -- Cardiovascular part 2 – antiarhythmica, anti hypertensives -- Nephrology – dialysis -- How to use drugs in obese children and adolescents -- Haematology – CSFs, erythropoietin -- Antiretroviral/HIV -- Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life -- Antihelminth treatment -- Inflammatory bowel disease -- Constipation; laxatives -- Psychiatric diseases in children and adolescents -- Oncology – cell reducing agents part 1, part 2, part 3 -- Immunosuppressants – organ transplantation -- Bone marrow/stem cell transplantation -- Narcotic sparing approaches and the shift towards paracetamol in neonatal intensive care -- Disorders of puberty: pharmacotherapeutic strategies for management.
    Abstract: This volume provides readers with the most updated scientific information on the efficacy and safety of medicines for children and adolescents. The book enriches the understanding of pediatric pharmacotherapy for health professionals, regulatory agencies, pharmaceutical companies and learned societies. It contains important information on the pharmacodynamics and pharmacokinetics of drugs. It summarizes the latest investigations on the effects of pharmacological treatments in relation to and dependent on age, gender, fat mass and disease status. Therefore and importantly, this volume reviews the latest data on how pharmacotherapy has to be adjusted and personalized in regards to stages of development and during the pediatric lifespan from neonate through adolescence. In addition, the topic of rare diseases and special challenges for pharmacotherapy will be included and will provide readers with the necessary knowledge to handle complex diseases and treatment strategies especially in relation to pharmacotherapy of rare and orphan diseases.
    Type of Medium: Online Resource
    Pages: VIII, 538 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504946
    Series Statement: Handbook of Experimental Pharmacology, 261
    DDC: 615
    Language: English
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  • 3
    Keywords: Pharmacology. ; Cardiology. ; Neurosciences. ; Clinical biochemistry. ; Pharmacology. ; Cardiology. ; Neuroscience. ; Medical Biochemistry.
    Description / Table of Contents: Part I: ROS Revisited: Changing the Focus from Oxidative Stress and Redox Biology to Redox Medicine -- Demystifying oxidative stress -- Oxidants in Physiological Processes -- Network Medicine-Based Unbiased Disease Modules for Drug and Diagnostic Target Identification in ROSopathies -- Part II Targeting antioxidant responses -- Development of Telintra as an Inhibitor of Glutathione S-Transferase P -- Perspectives on the Clinical Development of NRF2-Targeting Drugs -- Part III: Inhibiting ROS formation and toxification -- NOX Inhibitors: From Bench to Naxibs to Bedside -- Nitric Oxide Synthase Inhibitors into the Clinic at Last -- Xanthine Oxidoreductase Inhibitors -- Monoamine Oxidase Inhibitors: From Classic to New Clinical Approaches -- Inhibition of Myeloperoxidase -- Part IV: Stimulating/substituting ROS -- Effects of Mammalian Thioredoxin Reductase Inhibitors -- Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation -- Tetrahydrobiopterin and Nitric Oxide Synthase Recouplers -- Part V: Repairing ROS damage -- Soluble Guanylate Cyclase Stimulators and Activators – Peter Sander -- Inhibitors of Advanced Glycation End Product (AGE) Formation and Accumulation.
    Abstract: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 425 p. 70 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685102
    Series Statement: Handbook of Experimental Pharmacology, 264
    DDC: 615
    Language: English
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  • 4
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    DDC: 615
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human physiology. ; Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human Physiology.
    Description / Table of Contents: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.
    Abstract: Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. .
    Type of Medium: Online Resource
    Pages: VII, 180 p. 16 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030580049
    Series Statement: Current Topics in Microbiology and Immunology, 428
    DDC: 615
    Language: English
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  • 6
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Pharmacology. ; Pharmaceutics.
    Description / Table of Contents: 1 Principles of pharmaceutical analysis in drug stability and chemical kinetics -- 2 Guidelines for drug stability and stability testing -- 3 Chemical kinetics and its applications in drug stability -- 4 Methods and protocols for drug stability studies -- 5 Physical basis of degradation of pharmaceutical products -- 6 Role of microbiological degradation on drug stability -- 7 Role of decomposition on drug stability -- 8 Role of catalysis in drug stability -- 9 Analytical techniques for the assessment of drug stability -- 10 Stability of pharmaceutical products -- 11 Role of kinetic models in drug stability -- 12 Stability studies of vaccines -- 13 Stability studies of proteinous compounds -- 14 Stability studies of extemporaneous pharmaceutical products -- 15 Stability studies of parenteral products -- 16 Stability studies of solid dosage forms.
    Abstract: This book comprehensively reviews drug stability and chemical kinetics: how external factors can influence the stability of drugs, and the reaction rates that trigger these effects. Explaining the important theoretical concepts of drug stability and chemical kinetics, and providing numerous examples in the form of illustrations, tables and calculations, the book helps readers gain a better understanding of the rates of reactions, order of reactions, types of degradation and how to prevent it, as well as types of stability studies. It also offers insights into the importance of the rate at which the drug is degraded and/or decomposed under various external and internal conditions, including temperature, pH, humidity and light. This book is intended for researchers, PhD students and scientists working in the field of pharmacy, pharmacology, pharmaceutical chemistry, medicinal chemistry and biopharmaceutics. .
    Type of Medium: Online Resource
    Pages: XIV, 284 p. 22 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564260
    DDC: 615
    Language: English
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  • 7
    Keywords: Pharmacology. ; Pharmacy. ; Medicinal chemistry. ; Pharmacology. ; Pharmacy. ; Medicinal Chemistry.
    Description / Table of Contents: Abelmoschus maschatus -- Abrus precatorius -- Abutilon indicum -- Acacia catechu -- Acacia nilotica (A. arabica) -- Achillea millefolium -- Achyranthes aspera -- Aconitum napellus -- Acorus calamus -- Adiantum venustum (Adiantun capillus-veneris) -- Aegle marmelos -- Agrimonia eupatorium.-Alhagi maurorum -- Alkanna tinctoria -- Allium cepa -- Allium sativum -- Aloe vera -- Alpinia galangal -- Alpinia officinarum -- Alstonia scholaris -- Althaea officinalis -- Ammi majus -- Anacardium occidentale -- Anacyclus pyrethrum -- Andrographis paniculata -- Anethum graveolens -- Anthemis nobilis -- Apium graveolens -- Argemone Mexicana -- Aristolochia bracteolata -- Aristolochia fontanesii (A. longa) -- Aristolochia indica -- Aristolochia rotunda -- Artemisia absinthium -- Artemisia vulgaris -- Asparagus adscendens -- Asparagus officinalis -- Asparagus racemosus -- Atropa belladonna -- Azadirachta indica -- Bacopa monnieri -- Bauhinia tomentosa -- Berberis Aristata -- Berberis vulgaris -- Bombyx mori -- Borago officinalis -- Boswellia serrata -- Brassica nigra -- Butea monosperma -- Caccinia macranthera var. glauca (C. glauca) -- Caesalpinia bonduc (Caesalpinia bonducella) -- Cannabis sativa -- Capparis spinosa -- Cardiospermum halicacabum -- Carthamus tinctorius -- Carum carvi -- Cassia fistula -- Catharanthus roseus -- Celastrus paniculatus -- Centaurea behen -- Centella asiatica -- Chamaecrista absus (Cassia absus) -- Chamaemelum nobile (Anthemis nobilis) -- Cheilocostus speciosus (Costus Speciosus) -- Cichorium intybus -- Cinnamomum camphora -- Cinnamomum cassia -- Cinnamomum verum (C. zeylanicum) -- Citrullus colocynthis -- Clitoria ternatea -- Colchicum autumnale -- Colchicum luteum -- Commiphora gileadensis (C. opobalsamum) -- Commiphora myrrha -- Commiphora wightii (C. mukul) -- Convolvulus scammonia -- Cotoneaster nummularius -- Crocus sativus -- Croton tiglium -- Cullen corylifolium (Psoralea corylifolia) -- Cuminum cyminum -- Curcuma aromatica -- Curcuma longa -- Curcuma zedoaria -- Cuscuta chinensis -- Cuscuta reflexa -- Cydonia oblonga -- Cymbopogon schoenanthus -- Cyperus rotundus -- Datura stramonium -- Delphinium denudatum -- Dolichousnea longissimi (Usnea longissima) -- Doronicum pardalianches -- Embelia ribes -- Euphorbia hirta -- Euphorbia resinifera -- Ferula assa-foetida -- Ficus carica -- Ficus racemosa -- Foeniculum vulgare -- Fumaria officinalis -- Gentiana lutea -- Glycyrrhiza glabra -- Gymnema sylvestre -- Helleborus niger -- Hemidesmus Indicus -- Hibiscus rosa-sinensis -- Holarrhena pubescens (Holarrhena antidysenterica) -- Hyoscyamus niger -- Hyssopus officinalis -- Illicium verum -- Iris germanica -- Juniperus communi -- Justicia adhatoda (Adhatoda vasica) -- Lactuca sativa -- Lavandula stoechas -- Lawsonia inermis -- Lepidium sativum -- Linum usitatissimum -- Lupinus albus -- Malva sylvestris -- Marrubium vulgare -- Matricaria chamomilla -- Melia azedarach -- Melilotus officinalis -- Melissa officinalis -- Mesua ferrea -- Momordica charantia -- Moringa oleifera -- Myristica fragrans -- Myrtus communis -- Nageia nagi -- Nepeta cataria -- Nigella sativa -- Ocimum basilicum -- Ocimum gratissimum -- Ocimum tenuiflorum (Ocimum sanctum -- Operculina turpethum -- Paeonia emodi -- Pandanus odorifer (Pandanus Odoratissimus) -- Papaver somniferum -- Persicaria bistorta -- Phyllanthus emblica (Emblica officinalis) -- Picrorhiza kurroa -- Pimpinella anisum -- Piper cubeba -- Piper nigrum -- Pistacia lentiscus -- Plantago major -- Plantago ovata -- Plumbago zeylanica -- Polygonum aviculare -- Portulaca oleracea -- Quercus infectoria -- Rauvolfia serpentina -- Rheum emodi -- Rheum officinale -- Ricinus communis -- Rubia cordifolia -- Rumex vesicarius -- Ruta graveolens -- Salix caprea -- Salvia officinalis -- Santalum album -- Saussurea lappa -- Semecarpus anacardium -- Senna alexandrina -- Senna occidentalis -- Senna tora -- Sida cordifolia -- Smilax china;- Solanum americanum (S. nigrum) -- Sterculia urens -- Strychnos nux-vomica -- Swertia chirata -- Symplocos racemosa -- Syzygium cumini (Eugenia jambolana) -- Tamarindus indica -- Taraxacum officinale -- Taxus baccata -- Tephrosia purpurea -- Terminalia bellirica -- Terminalia chebula -- Thymus vulgaris -- Tinospora cordifolia -- Trachyspermum ammi (Ptychotis coptica) -- Tribulus terrestris -- Trigonella foenum-graecum -- Tussilago farfara -- Valeriana jatamansi (Nardostachys jatamansi) -- Verbena officinalis -- Vernonia anthelmintica (Baccharoides anthelmintica) -- Vigna unguiculata (Dolichos biflorus) -- Viola odorata -- Viscum album -- Withania somnifera -- Wrightia tinctoria -- Zingiber officinale -- Zingiber zerumbet -- Ziziphus jujuba -- Abbreviations -- Glossary -- Ayurvedic Terms of Diseases -- List of Referenced Books -- Index.
    Abstract: This book is designed to provide pharmacologists and researchers of natural products a comprehensive review of 200 medicinal plants, their vernacular names in various languages and their medicinal uses around the world, and in some cases, a historical perspective. Chemical constituents of each plant with the putative active constituent, and available up to date pharmacological studies (until 2017 on PubMed) with each medical activity explored and its relationship with traditional uses, are described for each plant. Any variations in chemical constituents and their effects on pharmacological studies outcome have been highlighted. All clinical trials conducted, with sufficient details, have been included. Nationalities and racial identities of participants of clinical trials are identified to impress upon the social, cultural and dietary influences on the clinical outcomes. Toxicity studies and potential interactions with prescribed drugs, and full spectrum of references are included.
    Type of Medium: Online Resource
    Pages: XXX, 2156 p. 199 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030168070
    DDC: 615
    Language: English
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  • 8
    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: Preface -- A Historic Review of the D3 Dopamine System from D3 Cloning to Clinical Trials in Schizophrenia and Drug Addiction -- Location, Location, Location: The Expression of D3 Dopamine Receptors in the Nervous System -- Recent Advances in Dopamine D3 Receptor Heterodimers: Focus on Dopamine D3 and D1 Receptor-Receptor Interaction and Striatal Function -- Involvement of DA D3 Receptor and Mitochondrial Functions in Structural Neuroplasticity of the Emotional Brain Circuits: Possible Role in Depression -- Dopamine D3 Receptor in Parkinson Disease: A Prognosis Biomarker and an Intervention Target -- Dopamine D3 Receptors: A Potential Target to Treat Motivational Deficits in Parkinson’s Disease -- Therapeutic Challenges of Cognitive Dysfunctions in Neuropsychiatric Disorders: Focus on the Dopamine D3 Receptor -- Dopamine D3 Receptor in Stimulant and Opiate Use Disorders -- The Role of D3 Dopamine-Receptors in Nicotine Dependence: A Synthesis of the Pre-Clinical and Clinical Literature -- The Dopamine D3 receptor in Food Addiction -- The Dopamine D3 Receptor Pharmacology and the Therapeutic Use of D3 Receptor Ligands in Schizophrenia -- D3 receptors and Restless Legs Syndrome -- D3 receptors and PET imaging.
    Abstract: The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of the knowledge on the dopamine D3 receptor and its role in human behavior and disease (i.e.: neuropsychiatric illnesses including schizophrenia, mood disorders, Parkinson’s disease, restless legs syndrome, addictions and substance use disorders). The volume is written by leading experts across multidisciplinary areas (imaging, biobehavioral testing and clinical trials, preclinical models / molecular pharmacology) converging on the therapeutic implications / potential of the D3 receptor. The D3 dopamine receptor is a member of the D2-like family of G protein-coupled receptors. It was cloned and characterized almost 25 years ago. A key feature of the D3 dopamine receptor system, which has attracted considerable attention, is its anatomical localization remarkably restricted to the limbic circuitry. This has spurred the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders (or to some features of neuropsychiatric disorders), including but not limited to psychosis, addictions and substance abuse, mood and movement disorders.
    Type of Medium: Online Resource
    Pages: VIII, 275 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031230585
    Series Statement: Current Topics in Behavioral Neurosciences, 60
    DDC: 615
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Bioinformatics. ; Oncology. ; Medicine Philosophy. ; Pharmacology. ; Computational and Systems Biology. ; Oncology. ; Philosophy of Medicine.
    Description / Table of Contents: Chapter 1. Revisiting the concept of human disease (Mariano Bizzarri, Mirko Minini, and Noemi Monti) -- Chapter 2. Dynamical aspects of pharmacokinetic/pharmacodynamics and quantitative systems pharmacology models (Ioannis Loisios-Konstantinidis, Panteleimon D. Mavroudis, Panos Macheras) -- Chapter 3. The efficiency of multi-target drugs: a network approach (Lucas N. Alberca, Alan Talevi) -- Chapter 4. Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases (Vinicius M. Alvesa, Stephen J. Capuzzia, Nancy Baker, Eugene N. Muratov, Alexander Trospsha, and Anthony J. Hickey) -- Chapter 5. Big Data, Personalized Medicine and Network Pharmacology: beyond the current paradigms (Alessandro Giuliani and Virginia Todde) -- Chapter 6. Epigenetic Control Using Small Molecules in Cancer (Tomohiro Kozako, Yukihiro Itoh, Shinichiro Honda, Takayoshi Suzuki) -- Chapter 7. Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread (Mark AJ Chaplain) -- Chapter 8. Precision Oncology vs Phenotypic approaches in the management of cancer: a case for the postmitotic state (Armando Aranda-Anzaldo and Myrna A.R. Dent) -- Chapter 9. Migrastatics - anti-metastatic drugs targeting cancer cell invasion (Aneta Gandalovičová , Daniel Rosel , Jan Brábek) -- Chapter 10. Critical steps in Epithelial-Mesenchymal transition as target for cancer treatment (Evgeny V. Denisov, Mohit Kumar Jolly, Vitaly P. Shubin, Alexey S. Tsukanov, Nadezhda V. Cherdyntseva) -- Chapter 11. Targeting the tumor-associated macrophages for ‘normalizing’ cancer (Julia Kzhyshkowska) -- Chapter 12. Tumor Reversion induced by embryo and oocyte extracts (Sara Proietti, Andrea Pensotti and Alessandra Cucina) -- Chapter 13. Trabectedin, a drug acting on both cancer cells and the tumor microenvironment (Paola Allavena, Manuela Liguori, Cristina Belgiovine) -- Chapter 14. Advances in Characterizing Recently-identified Molecular Actions of Melatonin: Clinical Implications (Russel J. Reiter, Ramaswamy Sharma, Sergio A. Rosales-Corral, Ana Coto-Montes, Jose Antonio Boga, Jerry Vriend) -- Chapter 15. Multitarget activities of Inositol and Inositol Hexakisphosphate (Ivana Vucenik) -- Chapter 16. Integration of Phytochemicals and Phytotherapy into Cancer Precision Medicine (Nadire Özenver and Thomas Efferth) -- Chapter 17. Synergistic Effects of Chinese Herbal Medicine and Biological Networks (Deep Jyoti Bhuyan, Saumya Perera1, Kirandeep Kaur, Muhammad A. Alsherbiny, Mitchell Low, Sai-Wang Seto, Chun-Guang Li, Xian Zhou) -- Chapter 18. Medicinal herbs: its therapeutic use in obstetrics and gynaecology (Irene Orbe, Daniel Paz, Leyre Pejenaute, Andrea Puente, Laura Diaz de Alda, Sandra Yague, Iñaki Lete) -- Chapter 19. Overcoming Antibiotic Resistance: New Perspectives (Matteo Bassetti, Elda Righi).
    Abstract: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
    Type of Medium: Online Resource
    Pages: XVI, 483 p. 49 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030328573
    Series Statement: Human Perspectives in Health Sciences and Technology, 2
    DDC: 615
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Human physiology. ; Neurosciences. ; Pharmacology. ; Human Physiology. ; Neuroscience.
    Description / Table of Contents: Comparison of K+ Channel families -- High-resolution structures of K+ channels -- Pharmacological approaches to studying potassium channels -- Cardiac K+ channels and channelopathies -- Cardiac hERG K+ channel as safety and pharmacological target -- Pharmacology of A-type K+ channels -- Kv7 channels and hyperexcitability disorders -- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain -- Potassium channels in cancer -- Kir channel molecular physiology, pharmacology and therapeutic implications -- The pharmacology of ATP-sensitive K+ channels (KATP) -- Calcium-activated K+ channels (KCa) and therapeutic implications -- The Pharmacology of two-pore domain potassium channels -- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits -- Peptide toxins targeting KV channels -- Therapeutic antibodies targeting potassium ion channels.
    Abstract: The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. .
    Type of Medium: Online Resource
    Pages: VIII, 545 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030840525
    Series Statement: Handbook of Experimental Pharmacology, 267
    DDC: 615
    Language: English
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  • 11
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Nutrition   . ; Food science. ; Pharmacology. ; Nutrition. ; Food Science.
    Description / Table of Contents: 1 Preface -- 2 Effects of Nutrients/nutrition on Toxicants/toxicity -- 3 Effects of Xenobiotics on Nutrition -- 4 Effects of Antinutritional Factors on the Digestibility, Bioavailability and Quality of Protein -- 5 Natural Toxicants Originating from Food/Diet -- 6 Food contaminants -- 7 Food additives -- 8 Food contact materials -- 9 Genetically modified food -- 10 Tolerable upper limits of nutrients -- 11 Risk assessment and Risk-benefit assessment -- 12 Nutrients/Nutrition and Drug Interaction -- 13 Phytochemicals and Health -- 14 Adverse Effects of Phytochemicals.
    Abstract: This book provides a broad overview of the chemicals in food that have the potential to induce adverse health effects. Nutritional Toxicology is an interaction of nutrition, toxicology, biochemistry and food science, etc. Its main research scope involves the effects of nutrients on metabolisms of toxicants and their mechanisms, the interaction of the toxicants and contaminants originated from diet with nutrients and nutrition process, the adverse health outcome of nutrients excess, as well as methodology of research and related food and nutrition regulation process. Also the risk assessment of toxicants and contaminants in foods, and risk benefit assessment of nutrients (dietary supplementation) has become an emerging topic. This book provides novel and provocative insights into the fields of nutrition, food science and toxicology. It also offers a state-of-the-art report on recent discoveries concerning nutritional toxicology and where the field is going. It mainly focuses on advances made over the past 20 years. It will benefit graduate students, researchers and food and nutrition related regulation parties.
    Type of Medium: Online Resource
    Pages: X, 384 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811908729
    DDC: 615
    Language: English
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  • 12
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Pharmacy. ; Bioinformatics. ; Pharmacology. ; Pharmacy. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. 'Network Target' Theory and Network Pharmacology -- Chapter 2. Application of Network Pharmacology Based on Artificial Intelligence Algorithm in Drug R & D -- Chapter 3. Commonly used Network Pharmacology Database -- Chapter 4. Commonly used Network Pharmacology Software -- Chapter 5. Network Pharmacology and TCM Modernization Case Studies -- Chapter 6. Network Pharmacology and Modern Drug R & D Cases -- Chapter 7. Drug-based Network Pharmacology Practice Process -- Chapter 8. Disease-based Network Pharmacology Practice Process -- Chapter 9. Drug-disease-based Network Pharmacology Practice Process.
    Abstract: This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
    Type of Medium: Online Resource
    Pages: XVII, 468 p. 163 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811607530
    DDC: 615
    Language: English
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  • 13
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Midwifery. ; Public health. ; Pharmacology. ; Midwifery. ; Public Health.
    Description / Table of Contents: Part I Environmental Harmful Factors -- 1 Introduction to Environmental Harmful Factors -- Part II Female Reproductive Processes and Diseases -- 2 Introduction of Female Reproductive Processes and Reproductive Diseases -- Part III Effects of Environmental Factors on Reproductive Process -- 3 The Influence of Environmental Factors on Ovarian Function, Follicular Genesis, and Oocyte Quality -- 4 Effects of environment and lifestyle factors on premature ovarian failure -- 5 Effects of Environment and Lifestyle Factors on Anovulatory Disorder -- 6 Effects of Cigarette Smoking on Preimplantation Embryo Development -- 7 Toxicical effects of BPDE on dysfunctions of female trophoblast cells -- 8 The Roles of Stress-Induced Immune Response in Female Reproduction -- 9 Effects of Environmental EDCs on Oocyte Quality, Embryo Development and the Outcome in Human IVF Process -- Part IV Effects of Environmental Factors on Reproductive Diseases -- 10 Effects of environmental endocrine-disrupting chemicals on female reproductive health -- 11 Definition and Multiple Factors of Recurrent Spontaneous Abortion -- 12 The Variations of Metabolic Detoxification Enzymes Lead to Recurrent Miscarriage and their Diagnosis Strategy -- Part V Effects of Environmental Factors on Fertility Preservation -- 13 The Effects of Negative Elements in Environment and Cancer on Female Reproductive System.
    Abstract: This book will focus on the harmful effect of environmental toxins on female reproductive health. Reproduction is the basis of the continuation of human beings, and environment is the basis of human survival. However, environmental pollution has become a potential risk factor for human reproductive health, which not only leads to many chronic diseases, but also causes certain harm to reproductive health. Compared to male reproduction, female reproductive process is more complex, the reproductive system is more fragile, and is more vulnerable to be damaged. The aim of this book is to review the research progress, to address the challenges, and to stimulate the development in the direction of environment and female reproductive health.
    Type of Medium: Online Resource
    Pages: XI, 313 p. 13 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813341876
    Series Statement: Advances in Experimental Medicine and Biology, 1300
    DDC: 615
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Human physiology. ; Molecular biology. ; Pharmacology. ; Human Physiology. ; Molecular Biology.
    Description / Table of Contents: General Overview of Organic Cation Transporters in Brain -- Organic Cation Transporter Expression and Function in the CNS -- Genetic and Epigenetic Regulation of Organic Cation Transporters -- Experimental Methods for Investigating Uptake 2 Processes In Vivo -- Substrates and inhibitors of OCTs and PMAT and therapeutic implications -- Organic Cation Transporters in Brain Histamine Clearance: Physiological and Psychiatric Implications -- Organic Cation Transporters in Brain Catecholamine Homeostasis -- The Interaction of Organic Cation Transporters 1-3 and PMAT with Psychoactive Substances -- Organic Cation Transporters in Psychiatric Disorders -- Organic Cation Transporters and Nongenomic Glucocorticoid Action -- Brain Plasma Membrane Monoamine Transporter in Health and Disease -- Regulation of Neurogenesis by Organic Cation Transporters: Potential Therapeutic Implications -- Organic Cation Transporter (OCT/OCTN) Expression at Brain Barrier Sites: Focus on CNS Drug Delivery.
    Abstract: Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS. This book discusses latest insights into the field laying an emphasis on health, disease and therapeutics. The chapter, “General Overview of Organic Cation Transporters in Brain”, of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 328 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030829841
    Series Statement: Handbook of Experimental Pharmacology, 266
    DDC: 615
    Language: English
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  • 15
    Keywords: Pharmacology. ; Clinical biochemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Pharmacy.
    Description / Table of Contents: Dedication -- Preface.-The carbonic anhydrases in health and disease -- Carbonic anhydrase isozymes as diagnostic biomarkers and therapeutic targets -- Targeting carbonic anhydrases in vascular and pulmonary disease -- Carbonic anhydrase inhibitors in ophthalmology: glaucoma and macular oedema -- Targeting carbonic anhydrase isozymes in the treatment of neurological disorders -- Potential of carbonic anhydrase inhibitors in the treatment of oxidative stress and diabetes -- An overview of carbonic anhydrase-related neoplasms -- The carbonic anhydrase IX interactome and the regulation of cancer progression -- Carbonic anhydrase IX: current and emerging therapies -- Carbonic anhydrase inhibitors: designing isozyme-specific inhibitors as therapeutic agents -- Carbonic anhydrase inhibitors: identifying therapeutic cancer agents through virtual screening -- Targeting carbonic anhydrase IX in tumour imaging and theranostic cancer therapy.
    Abstract: This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both the most up-to-date therapeutic application of CA-targeting and the latest research data that will provide a platform for the development of novel applications. The interested audience comprises scientists and clinicians from many relevant disciplines within science and medicine.
    Type of Medium: Online Resource
    Pages: XII, 288 p. 38 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030795115
    Series Statement: Progress in Drug Research, 75
    DDC: 615
    Language: English
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  • 16
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Physiology. ; Oncology. ; Neurosciences. ; Developmental biology. ; Pharmacology. ; Physiology. ; Oncology. ; Neuroscience. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Pharmacological thinking in WNT signaling -- Controlling WNT Signaling Specificity and implications for targeting WNTs pharmacologically -- WNTs on exosomes -- Strategies to target LRPs in WNT signaling -- Targeting the receptor tyrosine kinase ROR1 by small molecules -- Assessing WNT binding and Frizzled activation employing genetically encoded, biophysical sensors -- Disheveled proteins as crucial mediators of WNT signaling -- Destruction complex and regulation of CTNNB1 -- Strategies to therapeutically target WNT/PCP like signaling in disease -- Mining natural compounds to target WNT signaling - from mushrooms to corals -- FZD7 as a therapeutic target in intestinal cancer -- Targeting oncogenic WNT signaling with WNT derived peptides -- Targeting WNT signaling in lung pathology -- The role of WNT signaling in osteoarthritis and the therapeutic potential of its pharmacological targeting -- WNT signaling in Alzheimers disease and other neurodegenerative disorders - opportunities for therapy? -- Targeting WNT signaling as a risk.
    Abstract: This book reflects the state of the art of our understanding of the WNT signaling system, which comprises a network of signaling pathways initiated by the secreted WNT lipoglycoproteins, which are crucial for embryonal development, stem cell regulation, tissue homeostasis and repair. Dysfunction of this evolutionarily conserved signaling system leads to many diseases including developmental disorders, diverse forms of cancer, fibrosis, neurodegenerative disease and many more. The WNT signaling system is built upon 19 mammalian, secreted WNT lipoglycoproteins that interact with a plethora of distinct receptors, such as the G protein-coupled receptors called Frizzleds (FZD1-10), LDL receptor-like proteins (LRP5/6), receptor tyrosine kinases (ROR1, 2, RYK and PTK7). In addition, WNT pathways are tightly regulated by many secreted and cell-intrinsic negative regulators, such as soluble FZD-related proteins (SFRPs), Dickkopfs (DKKs), WNT-inhibitory proteins, TIKI, RNF43 and more. Understanding the basic mechanism in terms of receptor-ligand interaction, receptor selectivity, signal initiation and desensitization remain poorly understood, even though substantial advances have been made the recent years. Due to the involvement of the WNT signaling system in human disease, it appears obvious to target diverse branches pharmacologically and therapeutically. However, given the complexity of the system and its importance for stem cell regulation and tissue maintenance, therapy comes with obvious risks for severe side effects. The field is addressing the challenge to identify suitable targets and selective compounds for therapy allowing disease-selective therapeutic effects and balancing unwanted side effects. This book summarizes the current understanding of the basic and applied pharmacology in the WNT signaling system and bridges disciplines such as pharmacology, physiology, neurosciences, oncology and drug development.
    Type of Medium: Online Resource
    Pages: VIII, 422 p. 70 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030854997
    Series Statement: Handbook of Experimental Pharmacology, 269
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Chemistry, Organic. ; Food science. ; Biotechnology. ; Pharmacology. ; Organic Chemistry. ; Food Science. ; Biotechnology.
    Description / Table of Contents: Chapter 1 The World of Carbohydrates -- Chapter 2 Basic Knowledge of Glycobiology -- Chapter 3 Carbohydrates involved in Diseases -- Chapter 4 Detection of Carbohydrate by Colorimetric Methods -- Chapter 5. Analytical Techniques to Study Carbohydrates -- Chapter 6 Monosaccharide Composition Analysis -- Chapter 7 Carbohydrate Analysis of Glycoconjugates -- Chapter 8 Structural Characterization of Released Glycans -- Chapter 9 Analysis of Sialic Acids -- Chapter 10 Carbohydrate Microarray Technology -- Chapter 11 Analysis of Carbohydrates by Mass Spectrometry -- Chapter 12 Analysis of Carbohydrates by Nuclear Magnetic -- Chapter 13 Glycobioinformatics -- Chapter 14 Concluding Remarks. .
    Abstract: The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable. This book provides the principles and protocols of various fundamental carbohydrate analysis methods. Choice of method is entirely dependent upon the type of material being investigated (biological samples, food products, etc.), and the level of structural detail required, i.e. sugar content, compositional analysis, linkages between the sugar components, or the total chemical structure of a given molecule. Full structural characterization of carbohydrate chains requires significant time, resources, and skill in several methods of analysis; no single technique can address all glycan analysis needs. This book summarizes several existing analytical techniques (both chemical and physical) in an introductory volume designed for the non-expert researcher or novice scientist. While background in carbohydrate chemistry is assumed, all information necessary to understanding the described techniques is addressed in the text.
    Type of Medium: Online Resource
    Pages: XXV, 350 p. 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030777913
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 615
    Language: English
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  • 18
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Neuropharmacology. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery. ; Neuropharmacology.
    Description / Table of Contents: PART I. Polypharmacology as a New Branch of Pharmacology: Concept and Principles -- Basics of Polypharmacology -- Polypharmacology in Clinical Applications: Multitarget Multidrug-combination (MTMD-C) -- Polypharmacology in Clinical Applications: Multitarget Multidrug-single-formulation (MTMD-SF) -- Polypharmacology in Clinical Applications: Multitarget Single-drug (MTSD) -- Polypharmacology in Drug Discovery: Designed Epigenetic MTSD and Small-molecule MTSD -- Anti-cancer Polypharmacology -- Cardiovascular Polypharmacology -- Neuronal Polypharmacology -- Pulmonary Polypharmacology -- Polypharmacology of Metabolic Disease -- Polypharmacology of Infectious Disease -- Polypharmacology of Inflammation -- Anti-psychotics Polypharmacology -- Anti-aging Polypharmacology -- Polypharmacology in Drug Repurposing -- Polypharmacology and Unintended Drug Promiscuity -- Polypharmacology Pharmacokinetics -- The Future of Polypharmacology -- PART II. Polypharmacology in New Drug Development: Strategies and Protocols -- Designed MTSD Discovery Process -- Designed MTSD Discovery Strategies -- Designed MTSD Discovery Technologies -- Designed MTSD Discovery Databases -- Designed MTSD Target Deconvolution.-Designed MTSD Target Validation -- Designed MTSD Lead Identification and Optimization -- Designed MTSD Discovery Protocols -- Natural Products in MTSD Discovery -- Polypharmacology Procedures for Drug Repurposing -- Polypharmacology Procedures for Drug Promiscuity Discovery.
    Abstract: There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on Polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology on Polypharmacology. This book aims to meet the needs of making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of Polypharmacology targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy. Rich in illustrations and tables to showcase readers for better understanding the concepts and technologies related to Polypharmacology; Provides comprehensive, systemic, holistic, and explicit explanations and discussion of the fundamental knowledge, background information, conceptual evolution, and updated methodology, as well as in-depth mechanisms behind the knowledge and methodology of Polypharmacology; Main emphasis on rationally designed Polypharmacology or “multi-target, single-drug (MTD)” pharmacology, which represents the major future direction of Polypharmacology and Pharmacology; Describes the clinical applications of Polypharmacology to various human diseases in the clinical and preclinical settings; Contains a wide collection of the state-of-the-art Polypharmacology technologies applicable to the designed MTD discovery and the step-by-step descriptions of drug discovery process applying Polypharmacology principles and methodologies.
    Type of Medium: Online Resource
    Pages: XXV, 856 p. 12 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031049989
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Nanobiotechnology. ; Biomedical engineering. ; Drug delivery systems. ; Pharmaceutical chemistry. ; Pharmacology. ; Nanobiotechnology. ; Biomedical Engineering and Bioengineering. ; Drug Delivery. ; Pharmaceutics.
    Description / Table of Contents: Chapter 1. An introduction to respiratory diseases and an emerging need for efficient drug delivery systems -- Chapter 2. Inflammatory respiratory diseases: Correlation between Lung cancer and CoVid-19 -- Chapter 3. Advancements in translational respiratory research using nanotechnology -- Chapter 4. Chemical moieties as advanced therapeutics for targeting respiratory disorders -- Chapter 5. Phytochemicals and their nanoformulations targeted for pulmonary diseases -- Chapter 6. Nanocarriers: an advanced and highly effective approach for targeting chronic lung diseases -- Chapter 7. Vesicular drug delivery systems in respiratory diseases -- Chapter 8. Nanoparticles in chronic respiratory diseases -- Chapter 9. Applications of nanotechnology in pulmonary disease diagnosis -- Chapter 10. Nanotechnology in pulmonary disease diagnosis -- Chapter 11. Recent trends in Nanomedicine for diagnosis and treatment of pulmonary diseases -- Chapter 12. Strategies for enhanced drug targeting to inflamed lungs: Novel perspectives -- Chapter 13. Solid-Lipid Nanocarriers (SLN’s) based drug delivery for treating various pulmonary diseases -- Chapter 14. Microparticles, microspheres and microemulsions as pulmonary drug delivery systems for the treatment of respiratory diseases -- Chapter 15. Microparticles, microspheres and microemulsions in respiratory diseases -- Chapter 16. Advanced drug delivery systems targeting the immune system at cellular level in chronic respiratory diseases -- Chapter 17. Targeted Micellar Systems for Pulmonary Disease Intervention -- Chapter 18. Polymeric and inorganic nanoparticles targeting chronic respiratory diseases -- Chapter 19. Mucoadhesive drug delivery system in chronic respiratory diseases -- Chapter 20. Liposomal Drug Delivery: Therapeutic Applications in Chronic Respiratory Diseases -- Chapter 21. Biologics and vaccines for nasal and pulmonary drug delivery -- Chapter 22. Drug delivery systems for respiratory infections -- Chapter 23. Cell and Gene Therapies for Chronic Inflammatory Lung Diseases - Emerging Technological Trends and Advancements in Respiratory Medicine -- Chapter 24. Targeting biofilms in respiratory diseases using novel drug delivery systems -- Chapter 25. Advanced nanomaterials for drug delivery in chronic respiratory disorders -- Chapter 26. Emerging technological trends and advancements in respiratory medicine -- Chapter 27. Pulmonary pharmacokinetics and Biophysics -- Chapter 28. Clinical trials on novel advanced drugs for chronic respiratory disorders.
    Abstract: This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.
    Type of Medium: Online Resource
    Pages: X, 655 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811643927
    DDC: 615
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Medical sciences. ; Drug development. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Biometry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Biomedical Research. ; Pharmaceutics. ; Biostatistics. ; Medical Toxicology.
    Description / Table of Contents: Introduction-.What is a DMC?-. Is a DMC required?-. Who is On the DMC?-. What are the Legal and Ethical Aspects of DMC?-. How does the DMC work with SDAC and Sponsor and External Groups ? -- What Does a DMC Meeting Look Like -- What data is used for DMC outputs and who programs? -- What is Included in DMC Outputs? -- What does the DMC final DMC outputs look like and how is it delivered? -- What Types of Safety Outputs Does the DMC Receive? -- What types of efficacy outputs does the DMC receive? -- What types of other outputs does the DMC receive? -- What About In-Between DMC Meetings -- What types of formal interim analyses does the DMC review? -- What does the paperwork from meetings look like? -- How does the DMC assess risk-benefit for their decision making? -- What are some examples? -- Conclusions.
    Abstract: This book provides an overview of Data Monitoring Committees - what was done in the past, what is currently being done, and thoughts on improvements for the future. Previous works focused primarily on large cardiovascular studies (where DMCs originated more than 30 years ago) but updated references are needed that discuss smaller, more flexible studies in areas such as oncology. The authors have attended ~800 DMC meetings from ~200 distinct studies across all areas of clinical studies (oncology, rheumatology, rare diseases, cardiology, immunology, etc.) This wide range of expertise will be used, as well as the expertise that comes from working with virtually every large biotech/pharma and CRO for DMC work. The reader of the book will know when DMCs are needed or helpful, how to form the DMC, how to work with external CROs and with sponsor teams and the DMC to create needed DMC outputs, how the DMC meetings are conducted, and - especially for DMC members - what are considerations within the Closed Session to review safety/efficacy outputs to assess risk/benefit to make appropriate recommendations that protect the patient safety and trial integrity. This is a practical hands-on book on how to decide if a DMC is necessary, how to form the DMC, how to smoothly create the necessary materials for the DMC and have smooth running DMC meetings. There is no specialized training in school about how DMCs work - frequently people may have been in industry for many years without ever needing to work with a DMC. This book is the helpful reference for those new to these DMCs. The DMC work is critical to be correctly implemented as the implications of it are so great. This book provides the following: Thorough instructions on the steps needed to form and implement a Data Monitoring Committee for clinical trial evaluation; Includes practical and hands-on information on DMC implementation; Discusses a wide range of clinical trial – by phase and therapeutic area.
    Type of Medium: Online Resource
    Pages: XII, 111 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031287602
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Cytology. ; Toxicology. ; Immunology. ; Pharmacology. ; Pharmaceutics. ; Cell Biology. ; Toxicology. ; Immunology.
    Description / Table of Contents: Part I Anatomy, Physiology and Pharmacology of Macrophages -- Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective -- Introduction to Pharmacology of Macrophages from Drug Delivery Perspective -- Mechanisms and Ways of Macrophage Delivery -- Macrophage Associated Disorders: Pathophysiology, Treatment Challenges and Possible Solutions -- Understanding Macrophage Associated Diseases and Applications of Nano Drug Delivery Systems -- Part II Polymeric Nanoparticles for Macrophage Targeting -- Targeting of Macrophages: Basic and therapeutic Role of Polymeric Nanoparticles -- Polymeric Nanoparticles Based Drug and Gene Delivery to Macrophages -- Surface Modification of Nanoparticles for Macrophage Targeting -- Part III Lipid Nanoparticles for Macrophage Targeting -- Liposomes as Delivery System for Macrophage Targeting -- Solid Lipid Nanoparticles Based Drug and Gene Delivery to Macrophages -- In vivo Fate of Colloidal Carriers Undergoing Macrophage Targeting -- Nanoparticle-based Theranostics for Macrophage-associated Diseases -- Part IV Targeting Macrophages for Treatment of Various Diseases -- Tumor Associated Macrophages as Therapeutic Target for Drug/immune Therapy of Cancer -- Macrophage Targeting for Therapy of Autoimmune Diseases -- Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD) -- Macrophage targeting for therapy of intracellular infections -- Targeting Drugs and Nucleic Acids to Macrophages for Therapy of Inflammatory Diseases -- Macrophage Targeted Chemotherapy for Tuberculosis and other Respiratory Disease. -- Part V Specific Formulations and Clinical Trials on Macrophage Targeted Delivery -- Nano- and Microparticles Based Dry Powder Inhalers for Pulmonary Macrophage Drug Delivery -- Recent Trends in Clinical Studies on Macrophage Targeted Delivery -- Future Directions and Challenges in Macrophage Targeting. .
    Abstract: The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders. Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.
    Type of Medium: Online Resource
    Pages: XVIII, 556 p. 76 illus., 73 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030841645
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Cancer. ; Cancer Treatment. ; Pharmacology. ; Cancers. ; Cancer Therapy.
    Description / Table of Contents: Chapter 1_Introduction to Cancer -- Chapter 2_Effect of anticancer treatment approches on gut microbiota -- Chapter 3_Synbiotic: A promising approach for the treatment of cancer -- Chapter 4_Correlation between ROS and Synbiotics for effective treatment of cancer -- Chapter 5_Influence of synbiotics on inflammation and immune microenvironment for the treatment of cancer -- Chapter 6_Synbiotics in colorectal cancer -- Chapter 7_Synbiotics in cervical cancer -- Chapter 8_Synbiotics in prostate cancer -- Chapter 9_Synbiotics in gastric cancer -- Chapter 10_Synbiotics in lung cancer -- Chapter 11_Synbiotics in small cell pancretatic cancer -- Chapter 12_Synbiotics in breast cancer -- Chapter 13_Synbiotics in hepatocellular carcinoma -- Chapter 14_Synbiotics in ovarian cancer -- Chapter 15_Regulatory issues of synbiotics in cancer.
    Abstract: This book illustrates the significance of probiotics and prebiotics for the management of various types of cancers. The up-to-date chapters provide recent information about the effect of anticancer treatment approaches on gut microbiota, the correlation between ROS and synbiotics for effective cancer treatment, and the influence of synbiotics on inflammation and immune microenvironment for cancer treatment. It also describes the regulatory issues about synbiotics in the management of cancer. This book is an essential resource for scientists working in the field of cancer, pharmaceutical & clinical sciences, and cancer clinicians. This book is also very useful for undergraduate and postgraduate students of Pharmacy and Biotechnology and medical researchers, mainly working in microbiology, immunology, and cancer biology.
    Type of Medium: Online Resource
    Pages: XVII, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811975509
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Nanobiotechnology. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery. ; Nanobiotechnology.
    Description / Table of Contents: Part 1. Pharmaceutical Innovation and Research -- Chapter 1. Innovation in stabilization of biopharmaceuticals -- Chapter 2. Concepts in pharmacogenomics: tools and applications -- Chapter 3. Pharmacogenetics–a new approach for the selection of the right drug -- Chapter 4. Meeting the unmet challenges of pharmaceutical research using artificial intelligence -- Chapter 5. Pharmaceutical innovation and research in ayurved -- Chapter 6. Ayurveda intervention in perimenopausal syndrome -- Part 2. Drug Discovery and Development -- Chapter 7. Innovative strategies in drug discovery and pharmacoinformatics -- Chapter 8. Advances in peptide synthesis -- Chapter 9. Peptidomimetics in Medicinal Chemistry: The Art of Transforming Peptides to Drugs -- Chapter 10. Diverse Pharmacological Activities of 4-aminoquinoline and its Derivatives -- Chapter 11. Thiourea catalysts for synthesis of active pharmaceutical ingredients -- Chapter 12. The Chemistry and Pharmacology of Mandarin Orange -- Chapter 13. Recent progress in the pharmacology of phytoestrogens: emerging neuromodulators for treating anxiety and depression -- Chapter 14. Next-generation cell-based therapies to combat metastaticbrain tumor -- Chapter 15. Pharmacokinetics and Pharmacodynamics: Fundamentals and Role(s) in Drug Discovery and Development -- Chapter 16. An update on pharmacokinetic models -- Chapter 17. Pharmacodynamics: Basics and Applications in Drug Research -- Part 3. Drug Delivery and Nanotechnology -- Chapter 18. Technological innovations in pharmaceutical drug nanocrystals -- Chapter 19. Fixed Dose Combinations: Innovations and Research -- Chapter 20. Significance of Intranasal Drug Delivery Systems: Recent Trends and Clinical Investigations in Brain Disorders -- Chapter 21. Current challenges and nanotechnology-based pharmaceutical approaches for the treatment and control of visceral leishmaniasis -- Chapter 22. Polymeric Nanoparticles-based Drug Delivery Systems for Anticancer Therapy. Chapter 23. Carbon nanotubes: a review of toxicity and applicability in biomedical applications -- Chapter 24. Recent trends in topical herbal nanotherapeutics for psoriasis -- Part 4. Pharmaceutical Microbiology -- Chapter 25. Antibiotics: past, present, future, and clinical pipeline -- Chapter 26. Innovative strategies to tackle antimicrobial resistance -- Chapter 27. Molecular and mechanistic insights of yeast flocculation -- Chapter 28. Management of hepatitis virus C: current and future treatments -- Chapter 29. Tuberculosis: experimental models, innovations and challenges -- Chapter 30. Targeting outer membrane to tackle multi-drug resistant bacterial pathogens -- Chapter 31. Diphtheria-A Paradigmatic Vaccine Preventable Toxigenic Disease with Changing Epidemiology -- Chapter 32. Emerging and re-emerging infections: an overview.
    Abstract: This book covers several important aspects of pharmaceutical research and innovations. It presents important topics on drug delivery, novel microsponge, nanocrystals, polymeric nanoparticles, peptide synthesis, biopharmaceuticals, pharmacodynamics, yeast flocculation, neuromodulators, innovative drug discovery, pharmacoinformatics, aminoquinoline, thiourea crystals for API synthesis, FDCs and formulations research, ayurveda and natural products, and innovations to militate anti-microbial resistance (AMR). A chapter is devoted to the applications of Artificial Intelligence and Machine Learning in diverse sectors of the pharmaceutical industry, including drug discovery and development, drug repurposing, and improving pharmaceutical productivity. The book also reviews the role of pharmacogenomics and pharmacogenetics in drug development and precision medicine. Further, the book presents an updated summary of recent advances in the fields of nanomedicines and nano-based drug delivery systems. This book is useful to pharmaceutical sciences students, researchers, educators, and professionals in the pharmaceutical industry to understand the intricacies of new drug research and innovations.
    Type of Medium: Online Resource
    Pages: XXI, 770 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819923021
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Nanobiotechnology. ; Drug delivery systems. ; Pharmacology. ; Nanobiotechnology. ; Drug Delivery.
    Description / Table of Contents: Ch 1 Introduction to block co-polymers -- Ch 2 Role of block co-polymers in drug delivery -- Ch 3 Role of block co-polymers in enhancement of poor solubility of drugs -- Ch 4 Synthesis and Self–assembly of block copolymers -- Ch 5 Role of block co-polymers in treatment of brain disorders -- Ch 6 Role of block co-polymers in treatment of neurodegenerative disorders -- Ch 7 Role of block co-polymers in colon cancer -- Ch 8 Role of block co-polymers in lung cancer -- Ch 9 Role of block co-polymers in IBD -- Ch 10 Role of block co-polymers in vaccine -- Ch 11 Role of block co-polymers in treatment of GIT disorders -- Ch 12 Role of block co-polymers in topical drug delivery -- Ch 13 Role of block co-polymers in targeted drug delivery -- Ch 14 Role of block co-polymers in ocular drug delivery -- Ch 15 Role of block co-polymeric micelles in drug delivery -- Ch 16 Applications of block co-polymers as Stimuli Responsive Copolymers -- Ch 17 Patented block co-polymers for various Therapeutics Applications.
    Abstract: This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.
    Type of Medium: Online Resource
    Pages: XVII, 429 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819969173
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Immunology. ; Pharmacology. ; Immunology.
    Description / Table of Contents: Preface Chapter 1: Overview of the Immune System and its Pharmacological Targets -- Chapter 2: Modulation of the Innate Immune System -- Chapter 3: Modulation of the Adaptive Immune System -- Chapter 4: Respiratory Disorders of the Immune System and their Pharmacological Treatment -- Chapter 5: Inflammation of the Skin and its therapeutic topics -- Chapter 6: Inflammatory Diseases of the Gastrointestinal Tract and Pharmacological Treatments -- Chapter 7: Mechanisms of Autoimmunity and Pharmacologic Treatments -- Chapter 8: Transplantation: Immunologic Principles and Pharmacologic Agents -- Chapter 9: Immunopathogenesis, Immunization, and Treatment of Infectious Diseases -- Chapter 10: Cancer Immunotherapy.
    Abstract: Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are discussed in detail. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.
    Type of Medium: Online Resource
    Pages: XIX, 399 p. 118 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030199227
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Nanobiotechnology. ; Nanomedicine. ; Pharmacology. ; Nanobiotechnology. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Chapter 1. Macroporous cryogel-based systems for water treatment applications and Safety: nanocomposite-based cryogels and bacteria-based bioreactors -- Chapter 2. One dimensional Semiconducting Nanomaterials: Toxicity and Clinical Applications -- Chapter 3. Prospects of Safe use of Nanomaterials in Biomedicalapplications -- Chapter 4. Hyaluronic acid-based nanotechnologies for delivery and treatment -- Chapter 5. Theranostics nanomaterials for safe cancer treatment -- Chapter 6. Cardiovascular safety assessment of new chemical entities: current perspective and emerging technologies -- Chapter 7. Toxicology of pharmaceutical products during drug development -- Chapter 8. Safety and Risk assessment of food items -- Chapter 9. Non toxic Natural products as regulators of tumour suppressor gene function -- Chapter 10. Advancements in the safety of Plant medicine: Back to nature -- Chapter 11. Chemicals and their interaction in the aquaculture system -- Chapter 12. Zebrafish as a biomedical model to define developmental origins of chemical toxicity -- Chapter 13. Green synthesis of non toxic nanoparticles -- Chapter 14. Synthesis, characterisation and safety of titanium oxide nanoparticles -- Chapter 15. Characterisation of non toxic nanomaterials for biological applications -- Chapter 16. Toxicity assessment of nanoparticle -- Chapter 17. Safety of nanoparticles: emphasis on antimicrobial properties -- Chapter 18. Quantum dots for imaging and its safety -- Chapter 19. Genotoxicity evaluation of nanosized materia -- Chapter 20. Scaffoldmaterials and toxicity -- Chapter 21 Biological Safety and Cellular interactions of nanoparticles -- Chapter 22. Role of artificial intelligence in the toxicity prediction of drugs -- Chapter 23. Chemicals and rodent models for the safety study of alzheimer’s disease -- Chapter 24. Mitochondria-targeted liposomal delivery in Parkinson's disease: safety concerns -- Chapter 25. Routes of Nano-drug Administration and Nano-based drug delivery system and toxicity -- Chapter 26. Green Synthesised silver nanoparticles phytotoxicity and applications in agriculture: An overview -- Chapter 27 status of safety concerns of microplastic detection strategies -- Chapter 28. Impact of insecticides on man and environment.
    Abstract: This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.
    Type of Medium: Online Resource
    Pages: XVIII, 768 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811978340
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Medicinal chemistry. ; Pharmaceutical chemistry. ; Biotechnology. ; Biochemical engineering. ; Pharmacology. ; Medicinal Chemistry. ; Pharmaceutics. ; Biotechnology. ; Bioprocess Engineering.
    Description / Table of Contents: Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.
    Abstract: The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
    Type of Medium: Online Resource
    Pages: XI, 207 p. 174 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811923203
    Series Statement: Progress in Drug Research, 76
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Virology. ; Immunology. ; Pharmacology. ; Virology. ; Immunology.
    Description / Table of Contents: Rabies Life Cycle, Transmission and Pathogenesis -- History of Rabies and Rabies Vaccines -- Rabies vaccines for wildlife -- Human Rabies Vaccines -- Rabies vaccines, prophylactic, Peru -- Rabies Prevention in Asia: Institutionalizing Implementation Capacities -- Passive Immunity in Rabies Prophylaxis -- Rabies Little Virus Against Powerful Innate Immunity -- Novel Rabies Vaccines -- Assessing the potency of inactivated veterinary vaccines and oral live vaccines against rabies -- WHO Perspective on Rabies.
    Abstract: This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine. .
    Type of Medium: Online Resource
    Pages: VII, 205 p. 15 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030210847
    DDC: 615
    Language: English
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  • 29
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Forensic sciences. ; Medical jurisprudence. ; Pharmacology. ; Forensic Science. ; Forensic Medicine.
    Description / Table of Contents: Part 1: Introduction -- Post Mortem Forensic Toxicology -- Human Performance Toxicology -- Drug-Facilitated Sexual Assault -- Forensic Drug Testing -- Performance enhancing Drug Testing -- Drug Testing in Pain Management -- Pharmacokinetics and Pharmacodynamics -- Part II. Specimen Preparation -- Spectrophotometry -- Chromatography -- Derivatization -- Immunoassy -- Mass Spectrometry -- Quantitation -- Method Validation -- Measurement Uncertainty and Traceability -- Statistics in Forensic Toxicology -- Part III Analytes -- Alcohol -- Benzodiazapines -- Gammahydroxybutyric acid,- Miscellaneous Central Nervous System Depressants -- Opioids -- Cocanie -- Cannabis -- Amphetamines-Sympathomimetic Amines,- Hallucinogens and Psychedelics -- Antidepressants and Neuroleptics -- Miscellaneous Therapeutic Drugs -- Carbon Monoxide/Cyanide -- Inhalants -- Metals -- Part III Special Topics -- Stability of Drugs of Abuse in Biological Systems -- Postmortem Redistribution of Drugs -- Postmortem Clinical Testing -- Pharmacogenomics -- Hair Drug Testing -- Oral Fluid Testing -- Meconium Drug Testing -- Drugs in Embalmed Tissues.
    Abstract: The fifth edition of the best-selling Principles in Forensic Toxicology continues in the tradition of excellence in academic publishing. With over 10 years of classroom-tested and continually updated content, the new edition contains significant updates and 7 new chapters on new topics including drug-facilitated crimes, derivatization, quantitation, measurement uncertainty/traceability, statistics, oral fluid testing, and drugs in embalmed specimens. Part One covers the major sub-disciplines of forensic toxicology in addition to pharmacological concepts. Part Two addresses specimen preparation, laboratory testing and instrumental analysis, while Part Three discusses common analytes including cocaine, opioids, alcohol, and marijuana. Adopted for courses in many of the top universities for forensic science and used by respected medical examiner’s offices and crime laboratories worldwide, Principles of Forensic Toxicology prepares the next generation of forensic toxicologists and continues to be an important reference in professional practice.
    Type of Medium: Online Resource
    Pages: XIII, 691 p. 188 illus., 23 illus. in color. , online resource.
    Edition: 5th ed. 2020.
    ISBN: 9783030429171
    DDC: 615
    Language: English
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  • 30
    Keywords: Pharmacology. ; Toxicology. ; Pharmaceutical chemistry. ; Pharmacology. ; Toxicology. ; Pharmaceutics.
    Description / Table of Contents: Therapeutic and toxic concentration of drugs in biological matrices -- Analytical techniques for therapeutic drug monitoring and clinical toxicology -- Plasma therapeutic drug monitoring and clinical toxicology -- Dried blood spots in therapeutic drug monitoring and toxicology -- The role of artificial intelligence in therapeutic drug monitoring and clinical toxicity -- Therapeutic drug monitoring and optimal pharmacotherapy with medicines of narrow therapeutic index -- Therapeutic drug monitoring (TDM) and toxicological studies in alternative biological matrices -- Analyzing data from therapeutic drug monitoring, pharmacokinetics, and clinical toxicology studies -- Reducing toxicity in critically ill patients by using therapeutic drug monitoring -- Quality assurance of samples for therapeutic drug monitoring and clinical toxicology -- Therapeutic drug monitoring and toxicology of anticancer drugs -- Therapeutic drug monitoring and toxicology of immunosuppressant -- Therapeutic drug monitoring and toxicology: relevance of measuring metabolites -- Recent advances in nanosensors for Therapeutic Drug Monitoring (TDM) -- Organ toxicity by immunosuppressive drugs in solid organ transplantation -- Artificial intelligence-based techniques to assess drug toxicity in drug induced liver injury (DILI) disease -- Drug dose and therapy individualization -- Models for drug individualization: patient to population level -- Toxicity evaluation of nanomedicine -- Biochemical indices of drug toxicity -- Therapeutic drug monitoring and clinical toxicology: challenges and future directions.
    Abstract: This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges .
    Type of Medium: Online Resource
    Pages: XVIII, 381 p. 43 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031123986
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Pharmacology. ; Pharmacy. ; Career education. ; Pharmacology. ; Pharmacy. ; Career Skills.
    Description / Table of Contents: Fellowship 101 -- The First Professional Year (P1) -- The Second Professional Year (P2) -- The Third Professional Year (P3) -- The Fourth Professional Year (P4) -- Midyear Applications, Interviews, and Receptions -- Transitioning from Student to Fellow -- Navigating the Virtual Landscape.
    Abstract: For many Doctor of Pharmacy (PharmD) candidates, post-graduate training is a highly prestigious and sought after experience that can further one’s pre-existing education. Some of these post-graduate training opportunities include but are not limited to pharmacy residencies, pharmaceutical industry fellowships, and PhD/Masters programs. There is a large gap in the current Doctor of Pharmacy curriculum about pharmaceutical industry fellowship programs and potential pharmaceutical industry opportunities. Through the eyes of current industry fellows and professionals, this book serves as a resource to learn more about fellowship opportunities and their respective application processes. In addition, this manual aims to provide a clear and concise roadmap to achieving a career in industry through a fellowship program. Whether you are a current student pharmacist, post-graduate pharmacy trainee (pharmacy resident), or industry professional, this manual addresses the current landscape of industry fellowship programs, an overview of industry opportunities, and a glimpse into what being a fellow entails. Readers of this book can expect to gain: An overview of pharmaceutical industry fellowship programs and opportunities Helpful advice and insight from current fellows and industry professionals A streamlined pathway to navigating the fellowship application process An understanding of the journey from being a student, to achieving a fellowship, to becoming an industry professional This book bridges the gap in education surrounding pharmaceutical industry fellowships and pharmacy careers in industry and increases access to first-hand information and real-world perspectives of current professionals to provide a firm foundation for those interested in pursuing a career in industry or learning more about fellowship programs.
    Type of Medium: Online Resource
    Pages: XIX, 92 p. 4 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031357879
    Series Statement: SpringerBriefs in Pharmaceutical Science & Drug Development,
    DDC: 615
    Language: English
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  • 32
    Keywords: Pharmacology. ; Pharmacy. ; Pharmacology. ; Pharmacy.
    Description / Table of Contents: Introduction -- History of CROs: Including CRO Snapshots and a CRO Genealogy Chart -- The Pharmaceutical Development Process & Testing Requirements -- The Medical Device Development Process & Testing Requirements -- Functions and Types of CROs -- Labs in China and India -- Selection of CROs -- Study Directors and PIs -- Nuts and Bolts of Study Performance SCG/CBS -- Electronic Reporting Requirements (SEND & eCTD) -- Study and Project Monitoring -- Contracting, Pricing, and Cost of Works Performed by CROs -- Consultants and their Role -- Building Relationships: Maximizing your return on Expectations with a CRO -- Common Problems and their Solutions -- Appendices: A Toxicology Labs B Medical Device Labs C Phase I Labs D Analytical Labs E GMP Contract Facilities F Formulation G Dosage Forms H Clinical Testing I Regulatory Services J Forms and Checklists -- K Specialized Services -- L Consultants Known to be In-Practice -- Index. .
    Abstract: This volume provides a complete update of all the materials in prior volumes on the subject (including current directories to testing labs and other support establishments worldwide), while adding substantial new material on the following topics: · The history of CROs, including snapshots of CROs and a genealogy chart making clear where they came from and where they went. · Study directors and principal investigators. · The nuts and bolts of study performance. · Electronic reporting requirements – SEND and eCTD (required for NDA, BLA, ANDA, and IND submissions). · Consultants and their roles. · An expanded examination of common problems and their solutions. This book boasts complete directories to the global universe of operating labs – where they are, how to contact them, and what they do (including special capabilities). Additionally, checklists for qualifying labs and manufacturing facilities – and for auditing studies and projects at such facilities – are included. It is directed at those in industry (specifically directed at those working for companies using CRO services) but will also be of interest to scientists or administrators working in research organizations themselves. In this case, the contents of this new work are essential to the target reader because the work, regulations, and actors (CROs) have evolved and changed at a rapid pace in the 10 years since the earlier volume that the author published. Likewise, the companies using these services have come to all be almost completely dependent on outsourcing. The earlier texts remain the only source of their kind (paper or electronic) on the field and the only noncommercial guide to the global industry and this volume provides a complete update.
    Type of Medium: Online Resource
    Pages: XIII, 519 p. 19 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030430733
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Immunology. ; Inflammation. ; Pharmacology. ; Immunology. ; Inflammation.
    Description / Table of Contents: Intracellular TLRs (TLR3, TLR7, and TRL9) in host defense or TLRs in mast cells -- Toll-like receptors as drug targets in the intestinal epithelium -- Innate immune memory-priming, tolerance and exhaustion-in health and disease -- TLRs in brain immunity -- TLRs in cerebrovascular diseases -- TLRs in stem cells or progenitor cells -- TLRs in adaptive immunity -- Overview on TLRs in immunity -- TLR10 and its role in immunity.
    Abstract: The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans. The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.
    Type of Medium: Online Resource
    Pages: VIII, 314 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065125
    Series Statement: Handbook of Experimental Pharmacology, 276
    DDC: 615
    Language: English
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  • 34
    Keywords: Pharmacology. ; Clinical medicine Research. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Clinical Research. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Potentiality of Probiotics in Inactivation of Tetrodotoxin -- Chapter 2. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 3. Plant based Bioactive compounds in Cancer Therapeutics -- Chapter 4. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 5. Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immunobiological perspectives -- Chapter 6. The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery -- Chapter 7. The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study -- Chapter 8. Prebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives -- Chapter 9. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases. Chapter 10. Implications of probiotics and prebiotics on immune functions -- Chapter 11. Recent Trends in Natural Medicines and Nutraceuticals Research -- Chapter 12. Nutraceuticals-are alternative to modern medicines- Chapter 13. Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban -- Chapter 14. Drosophila melanogaster as an in-vivo model for the investigation of host microbiota interaction -- Chapter 15. Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development of Aquaculture.
    Abstract: The book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.
    Type of Medium: Online Resource
    Pages: XVI, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811689901
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Surgery. ; Dentistry. ; Veterinary medicine. ; Neurology . ; Orthopedic surgery. ; Pharmacology. ; Surgery. ; Dentistry. ; Veterinary Science. ; Neurology. ; Surgical Orthopedics.
    Description / Table of Contents: 1. History of development of botulinum toxin therapy in medical and surgical fields -- 2. Molecular structure and mechanisms of action of botulinum toxins as it pertains to clinical symptoms -- 3. Types of toxins in commercial use, their similarities and differences -- 4. A review of current Botulinum toxin treatment indications in medical field. - 5. Mechanisms of Analgesic effects of botulinum neurotoxins -- 6. Botulinum toxin treatment in Head and neck surgery -- 7. Botulinum toxin treatment of thoracic and abdominal surgery -- 8. Botulinum Toxin A in Abdominal Wall Reconstruction -- 9. Use of Botulinum toxin A in post-mastectomy breast reconstruction -- 10. Botulinum Toxins for Treatment of Pain in Orthopedic Disorders -- 11. Botulinum toxin for pediatric patients, Who? For what? When? -- 12. Botulinum Toxin Treatment in Plastic Surgery -- 13. Botulinum Toxin Treatment in Ophthalmology and Ophthalmic surgery -- 14. Botulinum Toxin Treatment in Gastrointestinal Disorders -- 15. Botulinum Toxin Treatment in Urological Disorders -- 16. Botulinum Toxin Treatment in Dentistry -- 17. Botulinum toxin treatment in Veterinary Medicine - Clinical implications -- 18. Future Perspectives of Botulinum Toxin Application In Dentistry.
    Abstract: All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine and furnishes the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.
    Type of Medium: Online Resource
    Pages: VIII, 398 p. 70 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506919
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Biochemical markers. ; Cytology. ; Analytical biochemistry. ; Pharmacology. ; Biomarkers. ; Cell Biology. ; Analytical Biochemistry.
    Description / Table of Contents: Preface -- Practical Aspects of NMR-Based Metabolomics -- Compound Identification in Mass Spectrometry-Based Metabolomics -- METABOLOMICS USING NMR – Avoiding the ‘Black-Box’ -- Natural products drug discovery: on silica or in silico?- Quantitative NMR Methods in Metabolomics -- Advancements in pulsed stable isotope resolved metabolomics -- Metabolomics in Cell Biology -- NMR-based metabolomics to evaluate individual response to treatments -- Pharmacometabolomics of Asthma as a road map to Precision Medicine -- Prospective metabolomic studies in precision medicine -- Chemotherapy-induced Peripheral Neuropathy -- Metabolomics of Respiratory Diseases.
    Abstract: This volume of the Handbook of Experimental Pharmacology, which celebrated its 100th anniversary in 2019, addresses the rapidly growing and evolving field of metabolomics. It has been compiled and designed to broaden and enrich your understanding as well as simplify a complicated picture of the diverse field of metabolomics. This is accomplished by chapters from experts in the field on basic principles as well as reviews and updates of analytical techniques. The variety and different perspectives of the NMR approaches are described in the chapters By David Wishart, Daniel Raftery and Ryan McKay, while mass spectrometry advances are covered by Charles R. Evans and Stefan Kempa. This book also reflects the state of the art in the application of metabolomics to cell biology (Marta Cascante and Ulrich Guenther) and chapters that share insights into the application of metabolomics in various diseases (Paola Turano and Claudio Luchinat, Rachel S. Kelly and Jessica Lasky-Su, Paige Lacy, and Angela Rogers. Relationships of metabolomics with drugs are highlighted by Robert Verpoorte (natural products drug discovery), by Oscar Millet and by Turano and Luchinat (perspectives in precision medicine) and by Daniel L. Hertz (drug-induced peripheral neuropathy). From the above list of diverse topics, we believe this book has interdisciplinary appeal and scholars with an interest in the role of metabolomics in achieving precision medicine will find it of particular or special interest.
    Type of Medium: Online Resource
    Pages: VIII, 384 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031268595
    Series Statement: Handbook of Experimental Pharmacology, 277
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Botanical chemistry. ; Bioorganic chemistry. ; Pharmacology. ; Plant Biochemistry. ; Bioorganic Chemistry.
    Description / Table of Contents: Chapter 1. Introduction of diabetes melitus and future prospects of natural products on diabetes melitus -- Chapter 2. Anoverview of hypoglycemic modern drugs -- Chapter 3. An overview of hypoglycemic biological drugs -- Chapter 4. An overview of hypoglycemic traditionaldrugs -- Chapter 5. Glycosides from natural sources in the treatment of diabetes mellitus -- Chapter 6. Isolation and Structure Elucidation of Hypoglycemic Compounds -- Chapter 7. Structural Characterization and Health Effects of Polysaccharides from Momordica charantia on Diabetes Mellitus -- Chapter 8. Effects of polysaccharides on reducing blood glucose based on gut microbiota alteration -- Chapter 9. An Overview of Polysaccharides and the influencefactors of Hypoglycemic Activity -- Chapter 10. Plant Secondary Metabolites with α-Glucosidase Inhibitory Activity. - Chapter 11. Rhinacanthin-C and Its Potential to Control Diabetes Mellitus -- Chapter 12. Regeneration of beta cells by inhibition of pro-apoptotic proteins through phytocompound in STZ induced diabetic albino wistar rats-invivo and insilico approach. - Chapter 13. Nitrogenous Compounds from Plant Origin in Management of -- Chapter 14. Plant Alkaloids with Antidiabetic Potential -- Chapter 15. The role of Alkaloids in the Management of Diabetes Mellitus -- Chapter 16. Traditional Indian Herbs for the Management of Diabetes Mellitus and their Herb-Drug Interaction Potentials: An Evidence-Based Review -- Chapter 17. Role of Micronutrients and Trace elements in Diabetes mellitus: A Review.
    Abstract: The purpose of this book is to introduce the classified chemical components of hypoglycemic compounds in natural products, summarize the recent research progress of natural products with hypoglycemic activity in the past 20 years, and provide the original analysis and development opinions of relevant scholars. Hypoglycemic compounds are to target diabetes mellitus, an important public health problem, one of four priority noncommunicable diseases (NCDs) targeted for action by world leaders. Diabetes mellitus is a common endocrine and metabolic disease, which not only causes physiological damage to patients' kidneys, cardiovascular and cerebrovascular vessels, peripheral blood vessels, nerves and eyes, but also causes mental and psychological pressure to patients. Due to the evidence that traditional medicine and natural herbal formula have advantages in treating diabetes, natural products with hypoglycemic activity have been studied extensively in recent years and have been accepted by many scholars all over the world. This book focuses on the progress on the study of the structure, hypoglycemic activities, structure-activity relationships and mechanism of a wide range of polysaccharides, flavonoids, saponins, alkaloids, terpenoids, polyphenols and other constituents. It will help students and researchers to understand current approaches and progress in the treatment of diabetes with natural products, which may also be beneficial to develop new hypoglycemic drugs.
    Type of Medium: Online Resource
    Pages: VIII, 307 p. 85 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811587917
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Human physiology. ; Immunology. ; Surgery. ; Pharmacology. ; Human Physiology. ; Immunology. ; Surgery.
    Description / Table of Contents: Review of the Pathophysiology of the Alloimmune response -- A Comprehensive Review of Calcineurin Inhibitors Used for Immunosuppression in Cardiac Transplantation -- Anti-proliferative Agents -- Mechanistic Target of Rapamycin (mTOR) Inhibitors -- Corticosteroids -- Induction therapy and antibodies -- Immunosuppression and Heart Transplantation -- Immunosuppression and Lung Transplantation -- Immunosuppression and renal transplant recipients -- Immunosuppression in Rheumatologic and Auto-immune Disease -- Immunosuppression in Bone Marrow Transplantation -- Immunosuppression in Multiple Sclerosis and Other Neurologic Disorders -- Novel immunosuppressive agents for the treatment of organ transplants -- Adverse Effects of Immunosuppression: Infections -- Malignancy: An Adverse Effect of Immunosuppression -- Adverse Effects of Immunosuppression:Nephrotoxicity, Hypertension and Metabolic Disease.
    Abstract: The goal of this book is to provide a guide and detailed review of immunosuppression in terms of molecular mechanisms of action, side effects and clinical trials that validated their utility. This includes their use in solid organ transplantation, bone marrow transplantation and autoimmune diseases and inflammatory diseases. This book is a critical review of these topics and a vital resource.
    Type of Medium: Online Resource
    Pages: VIII, 348 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031051180
    Series Statement: Handbook of Experimental Pharmacology, 272
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Medical microbiology. ; Medicinal chemistry. ; Pharmacovigilance. ; Pharmacology. ; Medical Microbiology. ; Medicinal Chemistry. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: Chapter 1. Global Approach for Drug Discovery and Development from Indian Traditional Medicine -- Chapter 2. Bioactive Natural Leads TargetingCancer Cell Metabolism -- Chapter 3. Omics Technologies and Development of Anti-diabetic Therapies from Prospective Natural Products -- Chapter 4. Amaryllidaceae Alkaloids as Anti-inflammatory Agents Targeting Cholinergic Anti-inflammatory Pathway: Mechanisms and Prospects -- Chapter 5. Neurodegenerative Diseases and Small Molecule Protein Chaperone Activator of Natural Origin -- Chapter 6. Role of Phytomolecules on the Basic Biology of Aging -- Chapter 7. Role of phytomedicine in alleviating oxidative stress mediated vascular complications in diabetes -- Chapter 8. Plant Based -Secretase (BACE-1) Inhibitors: A Mechanistic Approach to Encounter Alzheimer's Disorder -- Chapter 9. Bioactive Compounds of Mangroves as Potent Drug and in Nanoparticle Synthesis - Play a Pivotal Role in Combating Human Pathogens. Chapter 10. Medicinal Plants: A Rich Source of Bioactive Molecules Used in Drug Development -- Chapter 11. Cell-based Assays in Natural Product-based Drug Discovery -- Chapter 12. Allelochemicals: An Emerging Tool for Weed Management -- Chapter 13. Secondary Metabolites of Higher Plants as Green Preservatives of Herbal Raw Materials and Their Active Principles During Postharvest Processing -- Chapter 14. Importance of Chromatography Techniques in Phytomedicine Research -- Chapter 15. Reverse Pharmacology – A Tool for Drug Discovery From Traditional Medicine -- Chapter 16. Role of Modern Biological Techniques in Evidence-Based Validation of Ayurvedic Herbometallic Preparations -- Chapter 17. HPTLC Fingerprinting analysis of Phytoconstituents from Indigenous Medicinal Plants -- Chapter 18. Climate Change,Geographical Location and Other Allied Triggering Factors Modulate the Standardization and Characterization of Traditional Medicinal Plants: AChallenges and Prospect for Phyto-Drug Development -- Chapter 19. Molecular Docking Studies of Plant-Derived Bioactive Compounds: A Comprehensive in silico Standardization Approach -- Chapter 20. Standardization and Quality Evaluation of Botanicals with Special Reference to Marker Components -- Chapter 21. Analytical Standardization of Haridra Formulation by UV-VIS Spectrophotometry and RP-HPLC -- Chapter 22. Ethnobotanical survey: the foundation to evidence based validation of medicinal plants -- Chapter 23. Phytotherapeutics: The Rising Role of Drug Transporters in Herb-Drug Interactions with Botanical Supplements -- Chapter 24. An Insight into Herb Interactions: Clinical Evidence Based Overview -- Chapter 25. Pharmacovigilance of Herbal Medicines: An Overview -- Chapter 26. Herbal Drugs: Efficacy, Toxicity and Safety Issues -- Chapter 27. Herbal Drug Patenting -- Chapter 28. Safety and Regulatory Issues on Traditional Medicine Entrusted Drug Discovery -- Chapter 29. Pharmacovigilance of Herbal Medicine: An Evolving Discipline -- Chapter 30. Toxicity Studies Related to Medicinal Plants -- Chapter 31. Herb-Drug Interactions -- Chapter 32. Plant Based Traditional Herbal Contraceptive Use in India: Safety and Regulatory Issues -- Chapter 33. Traditional Medicine Stability and Pharmacokinetic Issue -- Chapter 34. Pharmacovigilance: Methods in developing the safety and acceptability of traditional medicines -- Chapter 35. Zoopharmacognosy (Plant-Animal Interaction) -- Chapter 36. Significance of Stability and Pharmacokinetic issues in Traditional Medicine -- Chapter 37. Pharmaceutical Formulations Development Based on the Polymers Obtained from Edible Plants: An Excellent Approach for the Betterment in Health Care Services -- Chapter 38. Evaluation of bioactivity of green nanoparticles synthesized from traditionally used medicinal plants: a review -- Chapter 39. Physicochemical, Micromeritics, Biomedical and Pharmaceutical Applications of Assam Bora Rice Starch -- Chapter 40. Natural Excipients in Pharmaceutical Formulations -- Chapter 41. A Wonder Plant Withania: Pharmacological and Chemical Perspectives -- Chapter 42. Immunomodulators and Phyto Drugs -- Chapter 43. Combined Effects of Plant Extracts on Ovarian Cell Functioning -- Chapter 44. Pterocarpussantalinus: A Wonder Gift of Nature -- Chapter 45. Phytochemicals And Investigations On Traditionally Used Medicinal Mushrooms -- Chapter 46. A Review On Investigational Studies Of Marine Macroalgae Spogomorpha Indica L -- Chapter 47. Validation of Traditional Claim of Oxalis debilis Kunth., An Ethnomedicinal Plant from North-eastern Region of India -- Chapter 48. Traditional Herbal Medicine Practiced in Plateau-Fringe and Rarh Districts of West Bengal, India -- Chapter 49. Pharmacology and Mechanisms of Natural Medicine in Treatment of Type 2 Diabetes Mellitus -- Chapter 50. Indian Traditional Herbs and Alzheimer’s Disease: Integrating Ethnobotany and Phytotherapy. .
    Abstract: The demand for traditional medicines, herbal health products, herbal pharmaceuticals, nutraceuticals, food supplements and herbal cosmetics etc. is increasing globally due to the growing recognition of these products as mainly non-toxic, having lesser side effects, better compatibility with physiological flora, and availability at affordable prices. In the last century, medical science has made incredible advances all over the globe. In spite of global reorganization and a very sound history of traditional uses, the promotion of traditional medicine faces a number of challenges around the globe, primarily in developed nations. Regulation and safety is the high concern for the promotion of traditional medicine. Quality issues and quality control, pharmacogivilane, scientific investigation and validation, intellectual property rights, and biopiracy are some key issues that restrain the advancement of traditional medicine around the globe. This book contains diverse and unique chapters, explaining in detail various subsections like phytomolecule, drug discovery and modern techniques, standardization and validation of traditional medicine, and medicinal plants, safety and regulatory issue of traditional medicine, pharmaceutical excipients from nature, plants for future. The contents of the book will be useful for the academicians, researchers and people working in the area of traditional medicine. .
    Type of Medium: Online Resource
    Pages: XII, 1151 p. 378 illus., 125 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581274
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Metabolism Disorders. ; Pharmacology. ; Metabolic Disease.
    Description / Table of Contents: Part I Obesity. Epidemiology of Obesity -- The Circadian Clock and Obesity -- Nutrition and Microbiome -- From Obesity to Diabetes: The Role of the Adipose Organ -- Targeting Epicardial Fat in Obesity and Diabetes Pharmacotherapy -- The Enteroendocrine System in Obesity -- Insights from Studies of White Adipose Tissue Using Single-Cell Approaches -- Obesity-Related Insulin Resistance: The Central Role of Adipose Tissue Dysfunction -- Obesity, Senescence, and Senolytics -- Obesity and Obstructive Sleep Apnea -- Part II Diabetes and Complications. Inter-Organ Crosstalk in the Development of Obesity-Associated Insulin Resistance -- Islet Inflammation and β Cell Dysfunction in Type 2 Diabetes -- NAFLD and NASH: The Metabolically Diseased Liver -- Diabetic Kidney Disease: From Pathogenesis to Novel Treatment Possibilities -- Diabetic Peripheral Neuropathy -- Part III Lifestyle Modifications and Future Treatments. Weight Loss Strategies -- Physical Activity, Obesity and Weight Loss Maintenance -- Bariatric/Metabolic Surgery -- Drugs for Treating Obesity -- Novel Drugs for Diabetes Therapy -- Novel Approaches to Restore Pancreatic Beta-Cell Mass and Function -- Precision Medicine and Obesity -- Targeting the Enteroendocrine System for Treatment of Obesity.
    Abstract: Obesity is a major risk factor for the development of type 2 diabetes and its associated complications, a major socio-economic burden for health care systems. The worldwide prevalence of obesity doubled since 1980 and as a consequence the number of patients with diabetes has been continuously rising with more than 450 Mio. people suffering from this disease at the present time. Substantial progress has been made in understanding the molecular pathways leading from excessive fat accumulation to metabolic perturbation and finally diabetes manifestation. This edition of the "Handbook of Experimental Pharmacology" aims to analyze new insight into the pathophysiology of obesity, to decipher the complex links to diabetes and its complications, and to collect most recent information on new strategies for prevention and treatment of obesity and diabetes.
    Type of Medium: Online Resource
    Pages: VIII, 513 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030999957
    Series Statement: Handbook of Experimental Pharmacology, 274
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Natural products. ; Botany. ; Ethnology. ; Pharmacology. ; Natural Products. ; Plant Science. ; Ethnography.
    Description / Table of Contents: 1. Introduction to Western Himalayas -- 2. Achillea millefolium L., Common Yarrow -- 3. Arisaema jacquemontii Blume, Jacquemont's Cobra Lily -- 4. Species of Arnebia genus found in the western Himalayas -- 5. Species of the Berberis genus found in the western Himalayas -- 6. Dactylorhiza hatagirea (D.Don) Soo – Himalayan Marsh Orchid -- 7. Fritillaria roylei Hook.f.: Himalayan Fritillary -- 8. Gentiana kurroo Royle: Himalayan Gentian -- 9. Habenaria intermedia D.Don and Habenaria edgeworthii Hook., f. ex Collett.: The Western Himalayan medicinal Plants -- 10. Humulus lupulus L.: Beer plant -- 11. Inula racemosa Hook. f. – Puskarmool: Its ethnobotanical uses, phytochemicals and pharmacological activities -- 12. Juniperus recurva Buch.-Ham. ex D.Don and Juniperus squamata D. Don: Himalayan Juniper -- 13. Lancea tibetica Hook.f. & Thomson: Ethnobotany, phytochemistry and pharmacology -- 14. Malaxis muscifera (Lindley) O. Kuntze. and Malaxis acuminata D. Don.: Jeevak -- 15. Picrorhiza kurroa Royle ex Benth.: Kutki -- 16. Species of the genus Polygonatum found in the Western Himalayas -- 17. Species of the genus Rhodiola found in the Western Himalayas -- 18. Saussurea lappa C.B. Clarke: Kushta/Kut -- 19. Saussurea lappa C.B. Clarke: Kushta/Kut -- 20. Species of the genus Selinum found in the western Himalayas -- 21. Swertia chirayita (Roxb. ex Flem.): Chirayata/Chiretta -- 22. Taxus wallichiana Zucc.: The Himalayan yew -- 23. Tribulus terrestris L.: Gokshur /Gokharu -- 24. Species the Genus Viola found in Western Himalayas.
    Abstract: This book presents a comprehensive guide to traditional immunity-boosting medicinal plants of the Himalayas, their traditional uses, phytochemistry, pharmacology, diversity, conversation, biotechnology, toxicology, as well as future prospective. All the chapters cover the latest advances in ethnobotany, phytochemistry, biochemistry, and biotechnology. The book offers a valuable asset for researchers and graduate students of chemistry, botany, biotechnology, microbiology, and the pharmaceutical sciences. The main purpose of the present book is to draw on the rich culture, folklore, and biodiversity of immunity-boosting medicinal plants of the Western Himalayas, with particular emphasis on the Indian Trans-Himalayan and Western Himalayan region. All the plants included in the present book are extensively used by the local tribes and people for their health-promoting properties from ancient times. This book will be a substantial contribution to the knowledge of the region and the country. Also, the book will be very useful to scientists, graduates, and undergraduates, along with researchers in the fields of natural products, herbal medicines, ethnobotany, pharmacology, chemistry, and biology. Further, it is an equally significant resource for a person working in different traditional medicinal systems; doctors (especially those engaged in Ayurveda, Chinese traditional medicinal system, Amchi, and allopathy); the pharmaceutical industry (for drug design and synthesis); biochemistry and biotechnology sciences; and the agricultural sciences. .
    Type of Medium: Online Resource
    Pages: XIX, 609 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811995019
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Therapeutics. ; Pharmacology. ; Therapeutics.
    Description / Table of Contents: Nano-technological Platforms and Manipulations for the Emerging Ocular Manifestations -- Phytonanomedicines as Topical Alternatives for the Treatment of Skin Cancer -- Nano-sized Labile and Particulate Ingredients in Topical Formulations: A Strategic Approach Against Photoageing and Photocarcinogenisis -- Application of Biocompatible Nanocarriers in Glaucoma: Challenges and Advances -- Nano-carriers for Natural Therapeutics in the Management of Neuropathic Pain -- Advances in the Delivery of Therapeutic Peptides -- Nanoformulations and Their Role in Colon Targeting -- Theranostic Nanoformulations: Merging Diagnostics and Therapeutics -- The Role of Nanoformulations in Nose-To-Brain Drug Delivery -- Cubic Lyotropic Liquid Crystalline Nanostructures: A Versatile Platform for Delivery -- Preformulation Challenges: The Concept Behind the Selection, Design, and Preparation of Nanoformulations -- Nanoethosomes for Topical Fungal Therapeutics -- Comparison of Therapeutic Efficiency of Nanoformulations of Curcumin vs. Tetrahydrocurcumin in Various Disorders -- Nanomedicinal Approaches of Phytotherapeutics to Treat Alzheimers Disease -- Nanoparticulate Approaches to Exploit the Pathophysiology of Rheumatoid and Osteoarthritis -- Emerging Nanotechnology in Chronic Respiratory Diseases -- Conventional and Non-conventional Approaches of Site-specific Targeting of Therapeutics in Some Infectious Diseases and Metabolic Disorders -- Nanoformulations in Human Health Conditions: The Paradigm Shift -- Magnetic Nanoparticles Nanoformulation for Alternative Therapy of Cancer by Super-paramagnetic Hyperthermia -- Nano-weapons Against Tuberculosis -- Drug-Excipient Interactions in Nanoformulations with Special Focus on Impurity Control per ICH guidelines.
    Abstract: This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.
    Type of Medium: Online Resource
    Pages: XVIII, 548 p. 106 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030418588
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Nanotechnology. ; Nanochemistry. ; Pharmacology. ; Nanotechnology. ; Nanochemistry.
    Description / Table of Contents: Part 1 Introduction and Biomedical Applications of Nanoparticles -- 1. Introduction to Nanomaterials and Nanotechnology -- 2. Biomedical Applications of Nanoparticles -- Part II-Polymeric Nanoparticles -- 3. Nanocrystallization and Nanoprecipitation Technologies -- 4. Microfluidics Technology for Nanoparticles and Equipment-. 5. Production of Nanocomposites via Extrusion Techniques -- 6. The Use of Supercritical Fluids Technologies for Nanoparticle Production -- 7. Salting out and Ionic Gelation Manufacturing Techniques for Nanoparticles -- 8. Nanogel Synthesis by Irradiation of Aqueous Polymer Solutions -- 9. Cellulose acetate based nanofibers: Synthesis, Manufacturing and Applications -- 10. Production of nanofibers, environmental challenges and solutions -- Part III-Lipid Nanoparticles -- 11. High Pressure Homogenization Techniques for Nanoparticles -- 12. Solvent emulsification evaporation and solvent emulsification diffusion techniques for nanoparticles -- 13. Ultrasound Activated Nanoemulsions -- 14. Multiple Emulsions: Emphasizing on industrial applications -- 15. Membrane techniques for the preparation of nanomaterials -- 16. Self-assembling Lipid Nanoparticles/Nanosystems (SLNN) using Hydrophilic Solvents: Overview and Industrial Uses -- 17. Nanoemulsions – An emerging technology in drug delivery -- Part IV- Metallic Nanoparticles -- 18. Manufacturing techniques for carbon nanotubes, gold nanoparticles and silver nanoparticles -- 19. Radio frequency (RF) plasma-based Synthesis of metallic Nano particles for Biomedical Application -- 20. Techniques for accurate sizing of nanoparticles -- 21. Silver nanoparticles synthesis from cyanobacteria: Environmental and biomedical applications -- 22. Selenium Nanoparticles: Green Synthesis and Exploitation -- Part V- Quality control for nanoparticles -- 23. Practical guidelines for the characterization and quality control of nanoparticlesin the pharmaceutical industry -- Part VI-Challenges in scale-up production of nanoparticles -- 24. Nanomedicine Scale-Up Technologies: Feasibilities and Challenges -- 25. Patent survey on recent technology for nanoparticles -- Part VII-Injectable Nanosystems -- 26. Injectable Nanosystems and Inherent Nano-Serum Interactions -- Part VIII- Future directions and challenges -- 27. Current Challenges and Future Directions in Nanomedicine.
    Abstract: This book provides an overview of nanoparticle production methods, scale-up issues drawing attention to industrial applicability, and addresses their successful applications for commercial use. There is a need for a reference book which will address various aspects of recent progress in the methods of development of nanoparticles with a focus on polymeric and lipid nanoparticles, their scale-up techniques, and challenges in their commercialization. There is no consolidated reference book that discusses the emerging technologies for nanoparticle manufacturing. This book focuses on the following major aspects of emerging technologies for nano particle manufacturing. I. Introduction and Biomedical Applications of Nanoparticles II. Polymeric Nanoparticles III. Lipid Nanoparticles IV. Metallic Nanoparticles V. Quality Control for Nanoparticles VI. Challenges in Scale-Up Production of Nanoparticles VII. Injectable Nanosystems VIII. Future Directions and Challenges Leading scientists are selected as chapter authors who have contributed significantly in this field and they focus more on emerging technologies for nanoparticle manufacturing, future directions, and challenges. .
    Type of Medium: Online Resource
    Pages: XV, 611 p. 155 illus., 117 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030507039
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Pharmacy. ; Biotechnology. ; Pharmacology. ; Pharmacy. ; Biotechnology.
    Description / Table of Contents: 1 Antiviral Drugs Against Herpesviruses -- 2 An Update on Antiretroviral Therapy -- 3 Structural Insights to Human Immunodeficiency Virus (HIV-1) Targets and their Inhibition -- 4 LEDGINs, Inhibitors of the Interaction between HIV-1 Integrase and LEDGF/p75, are Potent Antivirals with a Potential to Cure HIV Infection -- 5 Moving Fast Towards Hepatitis B Virus Elimination -- 6 Discovery and Development of Antiviral Therapies for Chronic Hepatitis C Virus Infection -- 7 Phytoconstituents as Lead Compounds for Anti-dengue Drug Discovery -- 8 Anti-influenza Drug Discovery and Development: Targeting the Virus and its Host by all -- 9 Search, Identification and Design of Effective Antiviral Drugs against Pandemic Human Coronaviruses -- 10 Peptide Based Antiviral Drugs -- 11 Covalent Antiviral Agents -- 12 Safe-in-Man Broad Spectrum Antiviral Agents -- 13 Exploiting Ubiquitin ligases for Induced Target Degradation as an Antiviral Strategy. .
    Abstract: This book summarizes state-of-the-art antiviral drug design and discovery approaches starting from natural products to de novo design, and provides a timely update on recently approved antiviral drugs and compounds in advanced clinical development. Special attention is paid to viral infections with a high impact on the world population or highly relevant from the public health perspective (HIV, hepatitis C, influenza virus, etc.). In these chapters, limitations associated with adverse effects and emergence of drug resistance are discussed in detail. In addition to classical antiviral strategies, chapters will be dedicated to discuss the non-classical drug development strategies to block viral infection, for instance, allosteric inhibitors, covalent antiviral agents, or antiviral compounds targeting protein–protein interactions. Finally, current prospects for producing broad-spectrum antiviral inhibitors will be also addressed. The book is distinctive in providing the most recent update in the rapidly evolving field of antiviral therapeutics. Authoritative reviews are written by international scientists well known for their contributions in their topics of research, which makes this book suitable for researchers not only within the antiviral research community but also attractive to a broad audience in the drug discovery field. This book covers molecular structures and biochemical mechanisms mediating the antiviral effects, while discussing various ligand design strategies, which include traditional medicinal chemistry, computational chemistry, and chemical biology approaches. The book provides a comprehensive review of antiviral drug discovery and development approaches, particularly focusing on current innovations and future trends.
    Type of Medium: Online Resource
    Pages: XI, 357 p. 142 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811602672
    Series Statement: Advances in Experimental Medicine and Biology, 1322
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Medical genetics. ; Human physiology. ; Pharmacology. ; Medical Genetics. ; Human Physiology.
    Description / Table of Contents: Preface -- Part 1 Modulation -- Cav1.1Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies -- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia -- Sympathetic Nervous System Regulation of Cardiac Calcium Channels -- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19 -- Part 2 Pharmacological Approaches -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits -- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors -- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies -- CACNA1C-Related Channelopathies -- CACNA1D-Related Channelopathies: From Hypertension to Autism -- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options -- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits.
    Abstract: The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.
    Type of Medium: Online Resource
    Pages: XII, 316 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031384370
    Series Statement: Handbook of Experimental Pharmacology, 279
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Food science. ; Medicinal chemistry. ; Pharmacology. ; Food Science. ; Medicinal Chemistry.
    Description / Table of Contents: 1 Zingiber officinale - Its Ethanobotanical Uses, Phytochemistry and Pharmacology -- 2 An Insight in to the Phytochemistry, Traditional uses and Pharmacology of Ziziphus spina-christi (L) Willd. (Sidr): An Edible wild plant of Arabian Peninsula -- 3 Traditional Uses, Phytochemistry and Pharmacological Profile of Salvadora persica Linn -- 4 Phytochemistry, Pharmacology and Applications of Ocimum sanctum (Tulsi) -- 5 Nigella sativa: Its Ethnobotany, Phytochemistry and Pharmacology -- 6 A Review on Ethnomedicinal, Phytochemistry and Pharmacological Activities of Rumex hastatus D. Don -- 7 Chemical Composition and Biological Uses of Crocus sativus L.(Saffron) -- 8 Positive Health Benefits of Saponins from Edible Legumes: Phytochemistry and Pharmacology -- 9 Taraxcum officinale: The Esculent Dandelion as Herbal Medicine -- 10 Arctium lappa: A Review on its Phytochemistry and Pharmacology -- 12 Cichorium intybus: A Comprehensive Review on its Pharmacological Activity and Phytochemistry -- 13 Phytochemical and Pharmacological Properties of Picrorhiza kurroa -- 14 Lady's Purse (Capsella bursa-pastoris L.)-Current perspective on its ethanopharmacological, therapeutic potential and phytochemistry -- 15 Ethnopharmaology, Phytochemistry and Biological Activities of Achillea millefolium: A Comprehensive Review -- 16 A Review on Traditional Uses, Phytochemistry and Pharmacological Activities of Verbascum thapsus -- 17 Acorus calamus - A Review on Its Phytochemical and Pharmacological Profile.
    Abstract: The book provides essential information on some of the promising edible medicinal plants and how these possess both nutritional as well as therapeutic value. The significance of the edible plants in traditional medicine and the importance of the distribution of their chemical constituents are discussed systematically concerning the role of these plants in ethnomedicine in different regions of the world. The current volume deals with the individual plants' phytochemical and pharmacological properties, emphasizing human health. The title would demonstrate the value of natural edible plants and introduce readers to state-of-the-art developments and trends in omics-driven research. This book is a single-source scientific reference to explore the specific factors that contribute to these potential health benefits and discuss how to maximize those potential benefits. Chemists, food technologists, pharmacologists, phytochemists, and all professionals involved with quality control and standardization will find in this book a valuable and updated basis for their work.
    Type of Medium: Online Resource
    Pages: IX, 522 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811649592
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Pharmacology.
    Description / Table of Contents: From the contents. Preface.-Part I: Molecular aspects of KOR -- Part II: Preclinical research on pharmacology of KOR agonists and antagonists in animals -- Part III: KOR agonists and antagonists in clinical use and in past and present clinical trials.
    Abstract: This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XI, 577 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030890742
    Series Statement: Handbook of Experimental Pharmacology, 271
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Pharmacology. ; Neuroscience. ; Psychiatry.
    Abstract: It has been almost forty years since Norman G. Bowery discovered and named this “non-GABAA” receptor the GABAB receptor. It has been almost ten years since the last comprehensive book presentation focused on GABAB receptors. The main goal of this book is to provide the field with a contemporary and comprehensive perspective on the GABAB receptor, its physiological relevance, and its therapeutic potential. The volume is organized into introductory and special interest sections presented by experts who study the GABAB receptor from structural, signaling, pharmacologic, physiological, pathophysiological, and therapeutic perspectives. The book aims to appeal to a broad spectrum of biomedical and clinical scientists - any scholars with an interest in GABAB receptor. The editors hope readers find this work to be thought-provoking, instructive, and informative.
    Type of Medium: Online Resource
    Pages: VII, 329 p. 70 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030913359
    Series Statement: Current Topics in Behavioral Neurosciences, 52
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Biomaterials. ; Pharmacy. ; Biomedical engineering. ; Pharmacology. ; Biomedical Research. ; Biomaterials. ; Pharmacy. ; Translational Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Marine biopolymers for oral delivery of drug -- Chapter 2. Marine polymer based nanocarriers for drug delivery application -- Chapter 3. Alginate: A promising biopolymer in drug delivery system -- Chapter 4. Chitosan Based Nanocomposite as Targeted drug delivery Carrier -- Chapter 5. Marine Biopolymer Based Oral In situ Gel: Drug Delivery Applications -- Chapter 6. Marine biopolymers for transdermal drug delivery -- Chapter 7. Marine polysaccharides for skin drug delivery: hydrogels and microneedles solutions -- Chapter 8. Marine collagen: promising biomaterial in delivery of therapeutics for cancer therapy -- Chapter 9. Chitosan based gel for ocular drug delivery. Chapter 10. Marine based biopolymers for central nervous system drug delivery -- Chapter 11. Marine Biopolymers Based Anticancer Drug Delivery Systems -- Chapter 12. Marine-Derived polysaccharides: prospects for future pharmaceuticals and drug delivery systems.
    Abstract: This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.
    Type of Medium: Online Resource
    Pages: X, 453 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811647871
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Neurosciences. ; Pharmacology. ; Neuroscience.
    Description / Table of Contents: Experimental evidence for pesticide contribution in the pathogenesis of Parkinsonism: an update -- Epidemiological evidence for pesticide involvement in the etiology of Parkinson’s Disease: current state of affairs?” -- Manganese induced Parkinsonism: cellular and molecular mechanisms -- Manganese overexposures in occupational and environmental settings and Parkinsonism: where do we stand -- Aberrant dopamine metabolism as a focal point in the mechanism of environmental contaminant-induced dopaminergic dysfunction -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Emerging contaminants as contributors to Parkinsonism: focus on PhiPs -- Protein kinase C-delta (PKC-delta): a major molecular target for disparate dopaminergic toxicants -- Environmental contribution to redox dyshomeostasis in Parkinsonism.
    Abstract: “The book is comprised of individual reviews with the common goal of providing up-to-date state of the knowledge information on the role the environment plays in the pathogenesis of parkinsonism. The reviews focus on recent advances in the quest of deciphering the molecular and cellular mechanisms of parkinsonian dysfunction, highlight specific emerging dopaminergic toxicants and an alternative experimental model to study the link between environmental exposures and parkinsonism, and provide an update from epidemiological and experimental points of view related to the pesticide exposures and parkinsonism/Parkinson’s Disease association. Foremost experts in their respective fields are the senior authors on each chapter and the book fills a critical void that now exists as a book of similar nature has not been published in the last 15 years. Researchers and clinicians with an interest in Parkinson's Disease and related disorders, as well as toxicologists, graduate students, and the general public who are interested in the contribution of environmental factors to neurological dysfunction are among the readership for this book.”.
    Type of Medium: Online Resource
    Pages: V, 158 p. 14 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030874513
    Series Statement: Molecular and Integrative Toxicology,
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Natural products. ; Nanobiotechnology. ; Bioinformatics. ; Diseases Causes and theories of causation. ; Molecular biology. ; Pharmacology. ; Natural Products. ; Nanobiotechnology. ; Bioinformatics. ; Pathogenesis. ; Molecular Biology.
    Description / Table of Contents: 1. COVID-19: An overview of virology, mutations, pathology, epidemiology, diagnosis, preventions and treatments -- 2. The recent development of therapeutic strategies against COVID-19 -- 3. Plant immunoenhancers: Promising ethnopharmacological candidates for anti-SARS-CoV-2 activity -- 4. Herbal formulations in fighting against the SARS-CoV-2 infection -- 5. Rejuvenation of traditional medicine in the 21st century against SARS-CoV-2 -- 6. Traditional herbal medicines and their active constituents in combating SARS-CoV-2 infection -- 7. Antiviral phytocompounds against animal-to-human transmittable SARS-CoV-2 -- 8. Plants-derived bioactive compounds as potential ACE-2 inhibitors against SARS-CoV-2 infection -- 9. Insights into in silico methods to explore plant bioactive substances in combating SARS-CoV-2 -- 10. Dietary plants, spices and fruits in curbing SARS-CoV-2 virulence -- 11. Therapeutic potential of selected medicinal plants for neurological disorders after the infection of COVID-19 -- 12. Glycyrrhizae Radix et Rhizoma (Gan Cao) for the management of COVID-19 -- 13. COVID-19-induced kidney disease: Ethnopharmacological intervention to ameliorate kidney damage and improve kidney function -- 14. Phytochemicals and nutraceuticals targeting SARS-CoV-2: An in silico analysis -- 15. Therapeutic and prophylactic effects of plant derivatives against SARS-CoV-2 -- 16. Therapeutic potential of essential oils against SARS-CoV-2 infection -- 17. Antiviral properties of South Indian plants against SARS-CoV-2 -- 18. Immune-boosting plants used in Turkish folk medicine and their potential against COVID-19 -- 19. A comparison study of medicinal plants used against SARS-CoV-2 and those recommended against malaria in Africa -- 20. Exploring the potential antiviral properties of Nigella sativa L. against SARS-CoV-2: Mechanisms and prospects -- .
    Abstract: This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing “Good Health and Well-Being,” which is one of “The Sustainable Development Goals (SDGs) 2030".
    Type of Medium: Online Resource
    Pages: IX, 590 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819936649
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Toxicology. ; Pharmaceutical chemistry. ; Medicinal chemistry. ; Natural products. ; Pharmacology. ; Toxicology. ; Pharmaceutics. ; Medicinal Chemistry. ; Natural Products.
    Description / Table of Contents: Chapter 1: Achillea biebersteinii Afan -- Chapter 2: Aesculus hippocastanum L. -- Chapter 3: Berberis crataegina DC. -- Chapter 4: Calendula officinalis L. -- Chapter 5: Camellia sinensis (L.) Kuntze -- Chapter 6: Capsella bursa-pastoris (L.) Medik. -- Chapter 7: Capsicum annuum L. -- Chapter 8: Cedrus libani A.Rich. -- Chapter 9: Chelidonium majus L. -- Chapter 10: Cichorium intybus L. -- Chapter 11: Cistus laurifolius L. -- Chapter 12: Coriandrum sativum L. -- Chapter 13: Cornus mas L. -- Chapter 14: Curcuma longa L..-Chapter 15: Cydonia oblonga Mill. -- Chapter 16: Cynara scolymus L. -- Chapter 17: Equisetum arvense L. -- Chapter 18: Foeniculum vulgare Mill. -- Chapter 19: Fraxiınus ornus L. -- Chapter 20: Fumaria officinalis L. -- Chapter 21: Helichrysum plicatum DC. -- Chapter 22: Hyoscyamus niger L. -- Chapter 23: Juglans regia L. -- Chapter 24: Laurus nobilis L. -- Chapter 25: Liquidambar orientalis Miller -- Chapter 26: Matricaria chamomilla L. -- Chapter 27: Melissa officinalis L. -- Chapter 28: Momordica charantia L. -- Chapter 29: Nigella sativa L. -- Chapter 30: Olea europaea L. -- Chapter 31: Papaver somniferum L. -- Chapter 32: Rheum ribes L. -- Chapter 33: Rosa canina L. -- Chapter 34: Rosmarinus officinalis L. -- Chapter 35: Silybum marianum L. Gaertn. -- Chapter 36: Urtica dioica L -- Chapter 37: Valeriana officinalis L. -- Chapter 38: Viburnum opulus L.
    Abstract: This book collects information about the most popular ethnomedicinal plants, which are common in Turkey and around the world. It presents the ethnopharmacological records, in vivo and in vitro studies, side effects, chemical compositions and clinical studies of these medicinal plants. Its special focus is on the novel drug targets for disease and their possible mechanisms of action. It covers botanical descriptions the status of the plants, and food or drug interactions including precautions and warnings about the plants and the available market products. It provides an explanation of recorded and known plant administration dosages. Also, the gap between the traditional practice and scientific/clinical evidences in the use of ethnomedicinal plant is acknowledged. It is well known that traditional knowledge of the use of the medicinal plants in therapy is an important resource for the discovery of novel treatment options and drug targets. The main purpose of this book is to draw attention to ethnomedicinal plant species. Data on the therapeutic potentials of these medicinal plants can now be accessed from a single source. It provides an important resource for future research opportunities for harnessing the full potential of these plants.
    Type of Medium: Online Resource
    Pages: XII, 588 p. 119 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031077531
    DDC: 615
    Language: English
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    Keywords: Pharmacology. ; Pharmacy. ; Alternative medicine. ; Pharmacovigilance. ; Medicinal chemistry. ; Pharmacology. ; Pharmacy. ; Complementary and Alternative Medicine. ; Drug Safety and Pharmacovigilance. ; Medicinal Chemistry.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Measuring Herb-drug interaction and Synergy -- Chapter 3. Herb-Herb and Food-drug interactions -- Chapter 4. Pharmacokinetic interactions in synergistic herb-drug combinations -- Chapter 5. Antagonistic Herb-drug interactions -- Chapter 6. Synergistic Herb-drug interactions against bacteria -- Chapter 7. Synergistic herb-drug interactions against tuberculosis -- Chapter 8. Synergistic herb-drug interactions against viral diseases -- Chapter 9. Synergistic herb interactions with cardiovascular drugs -- Chapter 10. Synergistic herb interactions with anticancer drugs -- Chapter 11. Synergistic herb interactions with antidiabetic drugs -- Chapter 12. Synergistic herb-drug interactions against obesity -- Chapter 13. Synergistic Herb-Drug Interactions in Neurological Disorders -- Chapter 14. Synergistic Herb-drug interactions with antifungal and antiparasitic agents -- Chapter 15. Computational methods to study herb-drug interactions -- Chapter 16. Regulations and guidelines involving synergistic plant-drug interactions -- Chapter 17. Clinical trials on synergistic herb-drug interactions -- Chapter 18. QFuture prospects on synergistic herb-drug interactions -- Chapter 19. Conclusion.
    Abstract: Plant extracts or their pure natural constituents have been used traditionally for thousands of years for treating diseases with considerable success in India and other Asian countries. In addition, they have also been used as complements or supplements with conventional medicine. This book discusses the latest research in the application of combination therapy, namely herbs and drugs, in the treatment of a range of communicable and non-communicable diseases to achieve a synergistic effect. This synergy may help in reducing the amount of drug, its toxicity, side effects, and development of resistance as well as improve its efficacy. The book also discusses the pharmacodynamic and pharmacokinetic parameters, experimental tools to determine the impact of combination, computational approaches to identify synergy, statistical analysis of data, and clinical and regulatory issues. The book is useful for researchers in the fields of pharmacology, pharmacy and medicinal chemistry and those working in pharmaceutical and nutraceutical industries. This book could open up new strategies to focus on multiple targets to combat complex diseases unlike the single targeted drugs that are being currently marketed by the pharmaceuticals industries.
    Type of Medium: Online Resource
    Pages: XV, 276 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811951251
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Immunology. ; Neurology . ; Endocrinology. ; Cardiology. ; Pharmacology. ; Immunology. ; Neurology. ; Endocrinology. ; Cardiology.
    Description / Table of Contents: Part 1 Pharmacological Basic Principles -- The impact of sex and gender in medicine and pharmacology -- Sex differences in pharmacokinetics -- Clinical pharmacological considerations in transgender medicine -- Sex and gender differences in the pharmacology of the overactive urinary bladder -- Part 2 Pathologies of the Brain -- Sex differences in the evaluation and treatment of stroke -- Sex differences in pain and its treatment -- Therapeutics For Substance-Using Women: The Need To Elucidate Sex-Specific Targets For Better-Tailored Treatments -- Intersection of sex and depression: pathogenesis, presentation and treatments -- Biological and clinical implications of sex-specific differences in Alzheimer’s disease -- Part 3 Diabetes, metabolic diseases & cardiovascular risk -- Gender Differences In Cardiovascular Health: Hormonal Effects on Cardiovscular Risk And Management. - Sex Differences in Glucose Homeostasis -- Sex-gender-based differences in metabolic diseases -- Hypothalamic pituitary gonadal axis disorders impacting fertility in both sexes and the potential of kisspeptin-based therapies to treat them.
    Abstract: Biological sex and gender have a tremendous impact on the efficacy and safety of pharmacological interventions in virtually every disease state. This book presents a comprehensive and up-to-date overview on how sex-specific information is guiding the diagnosis and treatment of diseases affecting men and women, as well as of disease states that disproportionally affects women. Experts in various fields discuss both preclinical and clinical research that is contributing to a better understanding of the impact of sex in the presentation, etiology, treatment, and disease outcomes. Also discussed are the challenges encountered in implementing this growing body of knowledge into practice, as well as possible avenues to recognize and reduce health disparities between men and women so that therapeutic interventions are tailored and improved.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031426483
    Series Statement: Handbook of Experimental Pharmacology, 282
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Medicine, Preventive. ; Health promotion. ; Emigration and immigration. ; Medical policy. ; Diseases. ; Integrated Geography. ; Health Promotion and Disease Prevention. ; Human Migration. ; Health Policy. ; Diseases.
    Description / Table of Contents: Chapter1: Introduction -- Chapter2: Migration, Social Capital, and Health -- Chapter3: Disease Patterns: Communicable and Non-communicable -- Chapter4: Environmental Risks to Health -- Chapter5: Health Literacy of Migrants: Environmental Risks to Health -- Chapter6: Health Literacy of Migrants: Infectious and Non-Communicable Diseases -- Chapter7: Social Capital and Acculturation -- Chapter8: Social Capital and Health. .
    Abstract: This book brings readers the first scientific publication, using a mixed-method approach, on the internal migration dynamics regarding disease ecologies of informality and the interactions between social capital, lifestyles, health literacy, and health outcomes in the context of informal settlements in two developing countries - Ghana and Uganda. Through the prism of the concepts of place and scale, the book demonstrates the myriad of ways by which place or context directly and indirectly influence migrant's health knowledge, literacy, and outcomes in poor urban slums. Readers will learn about the multi-faceted linkages between social capital, acculturation, and health in places of deprivation via quantitative methods (e.g. surveys) and qualitative methods such as focus group discussions, in-depth interviews, concept mapping, and body health mapping. Chapters 1-2 provide an overview of internal migration into urban slums of Ghana and Uganda, and discuss the intersections between migration, social capital, and health in a global context. Chapters 3-7 address disease patterns, environmental risks to health, health literacy of migrants, social capital and acculturation, and social capital and health. The book will be of interest to professors and students, as well as policy makers in low to middle income countries for planning targeted interventions. .
    Type of Medium: Online Resource
    Pages: XVI, 153 p. 42 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030246938
    Series Statement: Global Perspectives on Health Geography,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Medical informatics. ; Geographic information systems. ; Medical economics. ; Medical care. ; Integrated Geography. ; Health Informatics. ; Geographical Information System. ; Health Economics. ; Health Care.
    Description / Table of Contents: Chapter 1 -- Introduction. Chapter 2 -- The shape of Japan: methods and data. Chapter 3 -- Death across life courses. Chapter 4 -- Cancer deaths. Chapter 5 -- Deaths from cerebrovascular and cardiovascular diseases. Chapter 6 -- Other major causes of death. Chapter 7 -- Synthesis.
    Abstract: This new health atlas of Japan presents a series of maps about the health of the contemporary Japanese population, i.e. detailed maps of health indicators in small areas using cartograms. This is the first comprehensive small-area based health atlas about contemporary Japan using vital statistics from 1995-2014. Each map is supplemented with concise explanations written by leading epidemiologists and health geographers in Japan. The book employs various cutting-edge methods in spatial epidemiology, Bayesian spatial smoothing for the reliable mapping of mortality indices, advanced cartographic transformations using the concept of aerial cartograms, and summary statistics of socioeconomic health inequalities. The atlas highlights geographical aspects of social gradients in health by comparing mortality maps with distribution of deprivation index during the recent long-lasting economic stagnation period of Japan known as the lost decades. This health atlas will be a useful resource for international comparisons between Japan and other advanced countries in terms of health and related socioeconomic disparities between regions. It will be of interest to public health practitioners, administrators, researchers and students working on health geography and public health.
    Type of Medium: Online Resource
    Pages: XXIX, 343 p. 336 illus., 335 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030227074
    Series Statement: Global Perspectives on Health Geography,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    Keywords: Geography. ; Physical geography. ; Environment. ; Agriculture. ; Biotic communities. ; Biodiversity. ; Geography. ; Earth System Sciences. ; Environmental Sciences. ; Agriculture. ; Ecosystems. ; Biodiversity.
    Description / Table of Contents: I General Part -- Part A - Ecological Basics (Autoecology) -- Part B - Ecological Basics (Synecology) -- Part C - Ecological Systems and Ecosystem Biology -- II Special Part -- Part D - ZB I: Zonobiome of the evergreen tropical rainforest or equatorial humid diurnal climate -- Part E - ZB II: Zonobiome of savannas, deciduous forests and grasslands of the tropical summer rainfall region -- Part F - ZB III: Zonobiome of hot deserts or subtropical arid climate -- Part G - ZB IV: Zonobiome of hardwoods or Mediterranean winter rainfall regions -- Part H - ZB V: Zonobiome of laurel forests or warm temperate humid climate -- Part I - ZB VI: Zonobiome of winter barren deciduous forests or temperate nemoral climate -- Part J - ZB VII: Zonobiome of steppes and cold deserts or arid temperate climate -- Part K - ZB VIII: Zonobiome of hardwood forests or temperate arid climate. Part K - ZB VIII: Zonobiome of taiga or cold temperate boreal climate -- Part L - ZB IX: Zonobiome of tundra or arctic climate -- Part M - Summary, conclusions -- III Final part.
    Abstract: Vegetation, soil and climate are the most important components of ecological systems. The book presents a compact synthesis of our current knowledge of the ecology of the Earth and is thus the basis for understanding the major interrelationships in a global perspective. In the first part, with a rich endowment of illustrations and photographic material, the well-introduced book deals with the essential processes and operations on the Earth's surface that lead to the formation of the vegetation cover with its distinctive zonation. In the second part, the individual vegetation zones as large-scale ecosystems (i.e. zonobiomes of the biosphere) are consistently described comparatively according to certain criteria. In a short and compact form, the main characteristics and structures as well as examples of ecosystem processes are discussed. The large-scale ecosystems are also the basis and reference system for all anthropogenic changes that have drastically altered vegetation over the last millennia, but especially in the 20th century. This book is a translation of the original German 1st edition Vegetation und Klima by Siegmar-W. Breckle and M. Daud Rafiqpoor, published by Springer-Verlag GmbH Germany, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. Authors Siegmar-W. Breckle long-time professor and head of the Department of Ecology at the University of Bielefeld (Germany). He continued the multi-volume work "Ecology of the Earth" by Heinrich Walter, published numerous articles and books on the ecology of many regions, especially the drylands combined with countless study trips around the globe. His research in deserts, tropics and high mountains is the basis for the corresponding chapters in this book. M. Daud Rafiqpoor, long-time research associate of the Academy of Sciences and Literature in Mainz and coordinator of two ecologically oriented long-term projects of this academy ("Three-dimensional Landscape Classification of the Tropics and Subtropics" and "Biodiversity in Change"). Numerous study trips in almost all tropical and subtropical mountains of the world. Publication of many papers and books on the geography and ecology of tropical and subtropical high mountains and Afghanistan.
    Type of Medium: Online Resource
    Pages: XXIV, 557 p. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783662640364
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Human geography. ; Peace. ; Human rights. ; Geography. ; Human Geography. ; Peace and Conflict Studies. ; Human Rights. ; Politics and Human Rights.
    Description / Table of Contents: Chapter1. Introduction -- Chapter2, Towards a Legal Framework on Internal Displacement in South Sudan -- Chapter3. Mediating Protection of Forcibly Displaced Populations in the Frontlines of the Central African Republic -- Chapter4. The Adequacy of Law and Policy Frameworks on Internal Displacement in Ethiopia: A Critical Appraisal -- Chapter5. Beyond Accountability and Eminent Domain: Development Rights and Development-Induced Displacement in Kenya -- Chapter6. A Review of Land and Property Rights of Internally Displaced Persons in Zimbabwe: Steps Towards Restitution -- Chapter7. Internally Displaced Children in Nigeria: A Rights-Based Situational Appraisal -- Chapter8. Straddled Between Government Forces and Armed Separatists: The Plight of Internally Displaced Persons from the Anglophone Regions of Cameroon -- Chapter9. National Protection of Internally Displaced Persons in Africa: Law and Policy Beyond the Rhetoric.
    Abstract: This volume examines the protection of internally displaced persons (IDPs) through an interdisciplinary lens, with a focus on IDPs in Africa. The novelty of this book resonates from the fact that it explores national perspectives on internal displacement, with the aim of providing a well-grounded engagement on the subject of internal displacement, for which very little exists. The chapter authors are drawn from various disciplines and institutional backgrounds, and provide context-based analysis and examine the situation in countries with significant population displacement. The work is a timely engagement, as the issue of internal displacement has emerged as a pertinent concern in Africa. Each of the chapters in this book draw on significant context-based knowledge and on issues for which there is a need for pertinent attention across the African countries. This book will be a significant reference point for researchers, professors, practitioners, judges, policy makers, international organizations, regional bodies, lawyers and scholars in the field of migration, forced migration, and regional institutions.
    Type of Medium: Online Resource
    Pages: VII, 113 p. 2 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030668846
    Series Statement: Sustainable Development Goals Series,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Urban policy. ; Law. ; Real estate business. ; Urban economics. ; Regional economics. ; Spatial economics. ; Geography. ; Urban Policy. ; Law. ; Real Estate Economics. ; Urban Economics. ; Regional and Spatial Economics.
    Description / Table of Contents: Chapter 1. Key determinants of spatial management systems in Europe (Paulina Legutko-Kobus, Maciej Nowak) -- Chapter 2. Determinants and effects of planning practice in Poland (PrzemysławŚleszyński) -- Chapter 3. Spatial development law in Poland and related problems (Maciej Nowak) -- Chapter 4. Determining the interdependence (including barriers and challenges) between legal regulations and planning practice (PŚ, MN PLK) -- Chapter 5. Summary and conclusions.
    Abstract: This book defines the dilemmas related to the interface between legal regulations and planning practice in the spatial management system. Based on specific case studies, it gives examples of possible problems and ways of solving them. It applies to Poland's standard and the determinants of spatial policy in other countries. It provides the basis for a developed international discussion and concretely suggests specific actions at local, regional and national levels.
    Type of Medium: Online Resource
    Pages: X, 119 p. 17 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030969394
    Series Statement: SpringerBriefs in Geography,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geography. ; Human geography. ; Cultural geography. ; Cartography. ; Physical geography. ; Economic geography. ; Geography. ; Social and Cultural Geography. ; Cartography. ; Human Geography. ; Physical Geography. ; Economic Geography.
    Description / Table of Contents: Concept, types, collection, classification and representation of geographical data -- Representation of geographical data using graphs -- Diagramatic representation of geographical data -- Mapping techniques of geographical data.
    Abstract: Representation of geographical data using graphs, diagrams and mapping techniques is a key for geographers and for researchers in other disciplines to explore the nature of data, the pattern of spatial and temporal variations and their relationships, and formulation of principles to accurately understand and analyze features on or near the earth’s surface. These modes of representation also enable the development of spatial understanding and the capacity for technical and logical decision making. The book depicts all types of graphs, diagrams and maps, explained in detail with numerous examples. The emphasis is on their appropriate data structure, the relevance of selecting the correct technique, methods of their construction, advantages and disadvantages of their use, and applications of these techniques in analyzing and realizing the spatial pattern of various geographical features and phenomena. This book is unique in that it reflects a perfect correlation between theoretical knowledge of geographical events and phenomena and their realistic implications, with relevant examples using appropriate graphical methods. The book serves as a valuable resource for students, researchers, cartographers and decision makers to analyze and represent various geographical data for a better, systematic and scientific understanding of the real world.
    Type of Medium: Online Resource
    Pages: XXXII, 310 p. 161 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811665851
    Series Statement: Advances in Geographical and Environmental Sciences,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Human geography. ; Corporate governance. ; Geography. ; Regional Geography. ; Human Geography. ; Corporate Governance.
    Description / Table of Contents: Changing Community Governance in the Coastal Fishing Regions -- Examining Geographical Methods for Analyzing Relationships Among Actors in Fishing Ground Use -- Rethinking the State of Fisheries Cooperative Associations Through the Long-Term Consolidation Movement in Japan -- Fisheries Resource Governance in Hyogo Seto Inland Sea: Fishers, the Government, Research Institutes and Fisher’s Organizations -- Fishery Activities in Response to the Rapid Decline of the Herring Catch in Hokkaido -- Adaptive Capacity in Fishery Restoration Process at Tsunami-Affected Areas: Assets, Flexibility and Social Organization -- Adaptive Governance of Coastal Fisheries Resources in Response to Isoyake (Seaweed Deforestation). .
    Abstract: Japan’s fisheries sector is undergoing a major restructuring. The coastal ecological change and natural disasters such as tsunami demand that communities transform or organize resource governance anew. Under the national policy of decentralization to cope with the aging and declining population, the availability of local infrastructure, both physical and social, plays a significant role in the adaptive capacity of the community. This book presents the historical and spatial dynamics of coastal fisheries resource governance in response to different environmental changes, its socio-political context, and challenges raised by academicians. The reader will find the national trends and geographical patterns of the administrative restructuring in the communities and fisheries cooperatives from abundant maps and figures, as well as a rich description of adaptive governance in the scale of region and community by ecological-historical approaches. Comparative analysis of the communities provides a practical framework to understand a variety of local resources in Japan’s coastal regions, which will serve as a guide to the development of alternative adaptive governance in community-based small-scale fisheries in the world.
    Type of Medium: Online Resource
    Pages: XIII, 159 p. 47 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813342408
    Series Statement: International Perspectives in Geography, AJG Library, 13
    DDC: 910
    Language: English
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  • 62
    Keywords: Geography. ; Underwater archaeology. ; Geographic information systems. ; Cultural property. ; Archaeology. ; Anthropology. ; Geography. ; Maritime Archaeology. ; Geographical Information System. ; Archaeology and Heritage. ; Cultural Heritage. ; Anthropology.
    Description / Table of Contents: Chapter1. Remains of the shipwreck: an introduction to the Iberian maritime and underwater landscape -- Chapter2. A paradigm of inter and multidisciplinary research: The ForSEAdiscovery project as a case study -- Chapter3. Life and Death in the Spanish Carrera de Indias: ships, merchants, cargoes and routes -- Chapter4. Iberian Ships of the Early Modern Period -- Chapter5. Ship Types in Portugal -- Chapter6. The Iberian Peninsula between two Seas: Shipbuilding Revolution in the Mediterranean and the Atlantic Ocean, 14th–15th centuries -- Chapter7. An insight into Mediterranean naval architecture in the 16th century through the texts of Nicolò Sagri (1538–1571). A comparative perspective with Ibero-Atlantic shipbuilding -- Chapter8. From the Baltic Sea to Andalusia: North European timber (and traders) in 16th-century Seville -- Chapter9. Supplying timber for His Majesty’s fleets: forest resources and maritime struggle in Portugal (1621–1634) -- Chapter10. Historical Documents as sources for the study of shipbuilding in Spain -- Chapter11. Iberian Documents and Treaties on shipbuilding -- Chapter12. Maritime vocabulary in texts: Fray Joseph de Ledesma (1701) -- Chapter13. GIS application on 16th-18th centuries Iberian Shipwrecks.
    Abstract: This two-volume set highlights the importance of Iberian shipbuilding in the centuries of the so-called first globalization (15th to 18th), in confluence with an unprecedented extension of ocean navigation and seafaring and a greater demand for natural resources (especially timber), mostly oak (Quercus spp.) and Pine (Pinus spp.). The chapters are framed in a multidisciplinary and interdisciplinary line of research that integrates history, Geographic Information Sciences, underwater archaeology, dendrochronology and wood provenance techniques. This line of research was developed during the ForSEAdiscovery project, which had a great impact in the academic and scientific world and brought together experts from Europe and America. The volumes deliver a state-of-the-art review of the latest lines of research related to Iberian maritime history and archaeology and their developing interdisciplinary interaction with dendroarchaeology. This synthesis combines an analysis of historical sources, the systematic study of wreck-remains and material culture related to Iberian seafaring from the 15th to the 18th centuries, and the application of earth sciences, including dendrochronology. The set can be used as a manual or work guide for experts and students, and will also be an interesting read for non-experts interested in the subject. Volume 1 focuses on the history and archaeology of seafaring and shipbuilding in the Iberian early modern world, complemented by case studies on timber trade and supply for shipbuilding, analysis of shipbuilding treatises, and the application of Geographic Information Systems and Databases (GIS) to the study of shipwrecks.
    Type of Medium: Online Resource
    Pages: IX, 373 p. 22 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030864606
    DDC: 910
    Language: English
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  • 63
    Keywords: Geography. ; History. ; Political science. ; Human geography. ; Cartography. ; Geography. ; History. ; Political Science. ; Human Geography. ; Cartography. ; Regional Geography.
    Description / Table of Contents: Chapter 1 Drawing the lines, knowing the borders. An overview of recent scholarship on boundary-making and modern regimes of territorialization -- Part I. Boundary Treaties and Joint Commissions: Theoretical Foundations and Praxis on the Ground -- 2. Modern State Sovereignty as Geometric Purification of Territory. Delimitation Theories and Practices in the 1864 Spanish-Portuguese Boundary Treaty -- 3. Delimitation of the Spanish-Portuguese Border and the Controversy over La Contienda -- 4.From a Line on a Map to Realities on the Ground. The French-German Joint Boundary Commission at Work (1871-1877) -- 5. Mexican Geographer Engineers and the Demarcation of Mexico's Borders -- Part II. Contesting the Naturalness of Borders. Cartographic Practices, Geographical Knowledge and Territorial Issues -- 6. Borders on Paper, Borders on the Ground. Boundary Commissions Under the Treaty of Madrid and Their Role in the Reinvention of the Rio de la Plata Frontier (1752-1759) -- 7. Rights of Use vs. Natural Boundary: Demarcation of the Iraty Forest Massif (Western Pyrenees, 17th-19th Centuries) 8. A Water Borderline Adrift Between France and Spain. The Bidasoa and the Bay of Higuer at the End of the 19th Century -- 9. Demarcation of the Border of the Spanish Protectorate in Morocco (1913–1931): Chronicle of Failure -- Part III. Concluding Essay -- 10. Borders at the Global Turn.
    Abstract: This book brings together ten empirically rich and theoretically informed contributions that aim to clarify both geo-historical specificities and common transnational and global features of the cultures and practices of boundary making that shaped modern statehood. Written by scholars from Spain, France, Italy, Argentina, Brazil and Mexico, the essays included in this volume provide a comparative international perspective on the processes of border formation, as well as an integrative approach that seeks to strengthen the links between renewed geo-historical studies and more contemporary-oriented border studies. The book is addressed to a wide range of researchers, including geographers, historians, political scientists and specialists in geopolitics and the history of international relations.
    Type of Medium: Online Resource
    Pages: XII, 172 p. 35 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030969042
    Series Statement: Historical Geography and Geosciences,
    DDC: 910
    Language: English
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  • 64
    Keywords: Geography. ; Geography.
    Description / Table of Contents: Introduction -- Surveying the Earth through the ages -- Geodesy in the 21st century - Global reference systems and modern geodetic space observation techniques -- Our planet in focus - Phenomena of global change -- Social relevance of high-precision measurement of our planet from space.
    Abstract: How does your cell phone know where you are right now? How is our planet changing due to geodynamic processes and ongoing climate change? How can these changes be precisely measured from space in order to obtain reliable information about the melting of ice sheets or the threat to coastal regions from rising sea levels? This popular science book provides answers to these and many other socially relevant questions. It is aimed at interested non-professionals who want to learn more about our fascinating planet, but also at experts in natural sciences. You are taken on an exciting journey through time from the first surveys in ancient times to the satellite era, which is providing us with a global view of our home planet. Illustrative examples demonstrate how deeply global positioning and navigation with satellites pervade our daily life, and what fundamental contributions geodesy makes to understanding the Earth system and determining the effects of climate change. With interview contributions by Günter Hein, Harald Lesch and Stefan Rahmstorf. This book is a translation of the original German 1st edition Mission Erde by Detlef Angermann et al., published by Springer-Verlag GmbH Germany, part of Springer Nature in 2021. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). Content and language were subsequently revised by the authors. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. The Authors Detlef Angermann holds a doctorate in geodesy and heads the Research Area Reference Systems at the Deutsches Geodätisches Forschungsinstitut of the Technical University of Munich. Roland Pail is Professor of Astronomical and Physical Geodesy at the Technical University of Munich. Florian Seitz is Professor of Geodetic Geodynamics and heads the Deutsches Geodätisches Forschungsinstitut of the Technical University of Munich. Urs Hugentobler is Professor of Satellite Geodesy and heads the Satellite Geodesy Research Facility of the Technical University of Munich.
    Type of Medium: Online Resource
    Pages: XII, 246 p. 74 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783662641064
    DDC: 910
    Language: English
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  • 65
    Keywords: Geography. ; Earth sciences. ; Environmental monitoring. ; Natural disasters. ; Geography. ; Earth and Environmental Sciences. ; Environmental Monitoring. ; Natural Hazards.
    Description / Table of Contents: Part1. Introduction and background -- Chapter1. Linking the impacts of tropical cyclones to the Sustainable Development Goals -- Part2. A Focus on Agriculture and Public Health -- Chapter2. Impacts of tropical cyclone Idai on cash crops agriculture in Zimbabwe -- Chapter3. A comparative study of flooding on food security of urban and rural households in Blantyre City and Chikwawa, Malawi -- Chapter4. Assessment of Cyclone Idai floods on local food systems and disaster management responses in Mozambique and Zimbabwe -- Chapter5. Impacts of Tropical Cyclones Idai and Kenneth on Public Health in Southern Africa -- Chapter6. Perspectives on safeguarding children in sustainable disaster mitigation in Zimbabwe -- Part3. Education, Water and Sanitation and Livelihoods -- Chapter7. Impacts of cyclone Idai and the road to recovery in education systems in Zimbabwe -- Chapter8. The Water Sanitation and Hygiene Perspective in Response to Cyclone Idai in Zimbabwe -- Chapter9. Struggles of Cyclone Idai floods survivors inhabiting spaces of vulnerability and reconstructing their fractured livelihoods -- Chapter10. The Reconstruction of Livelihoods by Survivors of Cyclone Idai in the Chimanimani District of Zimbabwe -- Part4. A Focus on Infrastructure and Settlement -- Chapter11. Planning for climate and cyclone resilient transport infrastructures in southern Africa: Lessons from Zimbabwe -- Chapter12. Impacts of Cyclone Idai on Human Settlements in Zimbabwe -- Chapter13. Social and physical vulnerability of settlements to hydro-climatic induced disasters: Lessons from Cyclone Idai in Zimbabwe -- Part5. Natural Resources, Oceans, Tourism and Other Losses -- Chapter14. The Impact of Cyclone Idai on natural and plantation forests in the Eastern Highlands of Zimbabwe -- Chapter15. Impact of Cyclone Idai on biodiversity and natural resources in Chimanimani District, Zimbabwe -- Chapter16. Impact of tropical cyclone Idai on tourism attractions and related infrastructure in Chimanimani, Zimbabwe -- Chapter17. Evidence of the impact of cyclones and floods on biodiversity and wildlife resources in Southern Africa -- Chapter18. Impact of cyclones and floods on seagrass habitats -- Chapter19. Economic Losses from Cyclones Idai and Kenneth, and Floods in southern Africa: Implications on Sustainable Development Goals -- Part6. The Policy Space -- Chapter20. Emerging Key Findings, Conclusions and Policy Recommendations.
    Abstract: Tropical cyclones in Southern Africa, also known as hurricanes or typhoons in other regions of the world, is a hot subject for academic research. This focus has been magnified by the need to consider tropical cyclones in the context of other global development agendas, that includes the 2030 Agenda for Sustainable Development and its inseparable 17 Sustainable Development Goals (SDGs), the Paris Agreement, the Sendai Framework for Disaster Risk Reduction and Habitat III’s New Urban Agenda. The ambitious SDGs challenge global and community leaders to make sure development addresses the nexus among poverty, inequality and employment creation, as well as care for the earth and its natural resources and biodiversity. The SDGs further present an agenda to eradicate hunger, bring quality education and sustain water and sanitation. The infrastructure development, human settlements, sustainable consumption and production, climate change, biodiversity and the ocean (blue) economy agendas are also pitched. Lastly, the 2030 Agenda for Sustainable Development encourages partnerships on delivering various programmes and projects at all spatial levels. However, as tropical cyclones continue to make multiple landfalls and ravage Southern Africa and other parts of the world, the achievement of the 2030 Agenda for Sustainable Development is threatened. To this end, this book addresses this gap by documenting the implications of tropical cyclones, drawing examples and case studies from recent tropical cyclones such as cyclone Idai and cyclone Kenneth that resulted in catastrophic impacts in 2019. The book comes as part of a series with three volumes. The other volumes include “Cyclones in Southern Africa Vol. 1: Interfacing the Catastrophic Impact of Cyclone Idai with SDGs in Zimbabwe” and “Cyclones in Southern Africa Vol 2: Foundational and Fundamental Topics”. Given the foregoing, the book is suitable as a read for several professionals and disciplines such as tourism and hospitality studies, economics, sustainable development, development studies, environmental sciences, arts, geography, life sciences, politics, planning and public health.
    Type of Medium: Online Resource
    Pages: XXVI, 322 p. 83 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030743031
    Series Statement: Sustainable Development Goals Series,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Geology. ; Physical geography. ; Economic geography. ; Human geography. ; Geography. ; Geology. ; Regional Geography. ; Physical Geography. ; Economic Geography. ; Human Geography.
    Description / Table of Contents: PART I - INTRODUCTION, POLITICAL GEOGRAPHY, ETHNIC GROUPS AND RELIGIONS -- Introduction -- I.1. General geographical features of Albania -- I.2. Historical and Political Geography -- I.3. Ethnic Groups and Religions -- I.3.2. Religions -- PART II - LANDSCAPE OF ALBANIA -- II.1. Geological construction -- II.2. The relief -- II.3. Climate -- II.4. Waters -- II.5. Soils -- II.6. Flora and fauna -- II.7. Albanian natural and cultural heritage -- PART III - DEMOGRAPHICS -- III.2. Sociocultural features -- III.2. Sociocultural features -- PART IV - THE ECONOMY -- PART V - GEOGRAPHIC REGIONS -- INDEX.
    Abstract: This book is one of the first to give a comprehensive and detailed overview of the complete geography of Albania in English. It highlights the most important and manifold potentials of nature, society and economy of Albania as well as development problems during different time periods. One focus lies on Albania's perspectives and challenges for the future. Beside natural aspects also topics such as migration, poverty, social situation, economy, urban development, regional disparities among others are discussed. This book appeals to academics and researchers of geography, regional development and related disciplines as well as teachers and students of geography, geology, natural sciences, social sciences, economics. The book is also attractive for media representatives, tourists and other interested individuals travelling to Albania.
    Type of Medium: Online Resource
    Pages: XXIV, 255 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030855512
    Series Statement: World Regional Geography Book Series,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Soil science. ; Agriculture. ; Ecology . ; Geography. ; Soil Science. ; Agriculture. ; Ecology.
    Description / Table of Contents: Application of RS-GIS-R for soil-land resources assessment, monitoring, and modelling -- Assessment of soil health and monitoring -- Soil and sediments pollution -- Microbiology of Soil and Sediments -- Soil Salinity and Sodicity -- Soil erosion and contamination from agricultural activities -- Digital soil mapping and carbon stock modelling -- Soil degradation and Risk assessment -- Agricultural Soil Pollution -- Risk Assessment of Heavy Metal Contamination -- Environmental Pollution of Soil and Anthropogenic Impact -- Soil pollution by industrial effluents and solid wastes -- Environmental impact and risk assessment -- Open source satellite data and GIS for soil resources mapping and monitoring -- Bioremediation in soil resources management and land use planning.
    Abstract: This book demonstrates the measurement, monitoring, mapping and modelling of soil pollution and land resources. This book explores state-of-the-art techniques based on open sources software & R statistical programming and modelling in modern geo-computation techniques specifically focusing on the recent trends in data mining/machine learning techniques and robust modelling in soil resources. Soil and agricultural systems are an integral part of the global environment and human well‐being, providing multiple goods and services essential for people worldwide and crucial for sustainable development. Soil contamination is an environmental hazard and has become a big issue related to environmental health. The challenge of the twenty-first century is to reduce the contaminant load and bring it to below permissible level. The contamination is not only a problem affecting local environments at the place of occurrence but also spreading to other regions because of easy transportation of pollutants. This leads to direct and indirect contamination of land and aquatic systems, surface water and groundwater, inducing significant risks for natural ecosystems. In this context, the spatial modelling, prediction, efficient use, risk assessment, protection and management of soil resources in the agriculture system are the key to achieving sustainable development goals and ensuring the promotion of an economically, socially and environmental sustainability future. The aim of this book on soil contaminants and environmental health: application of geospatial technology is to identify the soil and sediment quality, sources of contaminants and risk assessment and focuses on the decision-making and planning point of view through GIS data management techniques. This book covers major topics such as spatial modelling in soil and sediments pollution and remediation; radioactive wastes, microbiology of soil and sediments, soil salinity and sodicity, pollution from landfill sites, soil erosion and contamination from agricultural activities, heavy metal pollution and health risk; environmental impact and risk assessment, sustainable land use, landscape management and governance, soil degradation and risk assessment, agricultural soil pollution, pollution due to urban activities, soil pollution by industrial effluents and solid wastes, pollution control and mitigation in extreme environments. The content of this book is of interest to researchers, professionals and policy-makers whose work is in soil science and agriculture practices. The book equips with the knowledge and skills to tackle a wide range of issues manifested in geographic data, including those with scientific, societal and environmental implications.
    Type of Medium: Online Resource
    Pages: XXIV, 729 p. 208 illus., 188 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031092701
    Series Statement: Environmental Science and Engineering,
    DDC: 910
    Language: English
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    Keywords: Environmental geography. ; Human geography. ; Medical care. ; Integrated Geography. ; Human Geography. ; Health Care.
    Description / Table of Contents: 1-Adolescent Health in the MENA Region: Determinants and Distribution -- 2-Adolescent nutrition: a focus on the MENA -- 3-Addressing Social Determinants of Oral Health among Adolescents from MENA -- 4-Knowledge, Attitude and Practice in relation to Vitamin D Deficiency among older adolescents -- 5-Activity among Adolescents from the MENA -- 6-Exploring Factors for Predictive Modelling of Obesity and Overweight in Adolescents: Application to MENA Region -- 7-Determinants of Knowledge in relation to Sexual and Reproductive Health of Adolescents in the Middle East and North Africa Region -- 8-Growth Assessment in Adolescence: Measurement and Interpretation for the Middle East and North Africa -- 9-Oral health of adolescents in the MENA region -- 10-Demographic and Geographic Variations in Respiratory and Allergic Conditions among Adolescents in the United Arab Emirates -- 11-The Epidemiology of Diabetes Mellitus among in adolescents and their determinants in from the Middle East and North Africa Region -- 12-HIV and sexual health in MENA’s adolescents.
    Abstract: This 2-volumeset focuses on adolescent health in the Middle East and North Africa region (MENA), and presents the latest research on the health risk behaviours and social behaviours that adolescents from the MENA region engage in. While there has been a surge in peer-reviewed research publications on population health in the MENA region in the last couple of decades, very few books offer a resource to address the diverse negative influences that disproportionately affect adolescents and children in the MENA region, including increased tobacco consumption culture, low emphasis on physical activity, increased sedentary behaviours, weak health policies, and societal issues related to displacement and political conflicts. These books offer a synthesis of current knowledge on adolescent health issues in the MENA region, and aim to provide evidence-informed adolescent health care practices that address current issues related to mental, physical, reproductive and nutritional health. Volume 2 focuses on nutritional and reproductive health in the MENA region, predictive modelling of obesity, determinants of sexual and oral health, HIV, and diabetes. The study will aid health care professionals, policy makers, government organizations and health program planners to assess current policies and practices related to adolescent health in the MENA region, and to identify the best courses of action moving forward. .
    Type of Medium: Online Resource
    Pages: X, 199 p. 20 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030921071
    Series Statement: Global Perspectives on Health Geography,
    DDC: 910
    Language: English
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  • 69
    Keywords: Geography. ; Space in economics. ; Sustainability. ; Development economics. ; Education. ; Geography. ; Spatial Economics. ; Sustainability. ; Development Economics. ; Education.
    Description / Table of Contents: Part 1 Geospatial technologies -- The effect of an open educational resource (OER) on student teachers‘ abilities to diagnose students‘ written argumentation skills -- Development of the Online Geospatial Problem-Solving Instrument: Investigating Elementary Students’ perceptual processes in geospatial problem-solving. -- A Spatial Knowledge Infrastructure for the Aegean Archipelago -- A Virtual Window to the World: Using Story Maps for SDG Visibility and Environmental Educatio -- Education for sustainable water consumption in multinational collaboration teachers training: Goals and Challenges -- Connecting Literature and Web Maps: Hungarian writers and poets online -- Part 2: Education, Geography and new Geospatial technologies and tools -- Teaching Geography with a Web GIS Approach -- Education for Sustainability Using Cloud-based Geographic Information Systems at University -- Comparative Dimensions of teaching Geography & History in Austria and in Israel, Migration of Vienna Jewry during the 1930s -- Geographiic Education for the Promotion of Spatial Citizenship: Collaborrative Mapping for Learning About the Local Environment in a Global Context -- Part 3: COVID-19 and post-COVID -19 -- The Art of Geographical Analysis of Covid-19 Related Data -- Development of a Synthetic Index of Social Vulnerability to Covid-19 in the City of Zaragoza (Spain) -- Students’ Satisfaction with Synchronous Online Learning in Times of COVID-19: A Case Study of Greek Geography Students -- Can Climate Crisis Go Viral? A Review of Climate Change Communication Lessons in the Aftermath of the COVID-19 Pandemic -- Towards a EU’s Sustainable and Humane Border Regime -- Part 4: Gepspatial technologies and application in agriculture -- Pest Management with Precision Farming Tools: the Case of the Olive Fly (Bactrocera Oleae) -- Sustainable Networking Solutions in Remote IoT Environments: Use Cases, Challenges and Solutions for Smart Agriculture.
    Abstract: Geography is a discipline with a profound interdisciplinary character focusing on studying the complex interactions between nature and society. Geography can advance the level of knowledge and awareness and provide important contributions to support the achievement of Sustainable Development Goals. This book explores some of these issues, while also disseminating and supporting the efforts of geographers worldwide to promote the implementation of the SDGs. It offers local and global perspectives to a variety of topics covered by the SDGs, such as: How do different actors such as universities, companies and education actors respond to Sustainable Development Goals, especially during the complex context of the COVID pandemic? What is the role of novel spatial technologies and open/big data in achieving SDGs and how can Geography assist? How are new eco-social challenges positioned in a post-pandemic global change? What are novel educational contexts and resources that can be used to transform society toward sustainability of socioecological systems? What conceptual frameworks and strategies can contribute to the construction of societies based on human welfare and the care of nature? This book is focused on innovative sustainability-oriented geographical research on the above (and more) topics that explore the diverse social, environmental, economic and cultural contexts at various spatial scales. It also includes chapters that report on geographical education initiatives in schools and universities, the implication of geographers in community-based learning and increasing community's awareness in terms of environment, climate change and sustainable development as well as chapters that make use of geospatial technologies (e.g., remote sensing, GIS, etc.) both in geographical research and education for sustainable development are particularly relevant for the book.
    Type of Medium: Online Resource
    Pages: VII, 325 p. 93 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031407475
    Series Statement: Key Challenges in Geography, EUROGEO Book Series,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Human geography. ; Landscape ecology. ; Sociology, Urban. ; Data mining. ; Geography. ; Human Geography. ; Landscape Ecology. ; Urban Sociology. ; Data Mining and Knowledge Discovery.
    Description / Table of Contents: Smart Geography: 100th Years Bulgarian Geographical Society -- Part I: Towards Smart Geography -- BGS and the Contemporary Progress of the Geographical Science Towards Smart Geography -- Smart Geographies and the Political Economy of Innovation and Inequality -- Evaluate Turkey's Climate Classification by Clustering Analysis Method.
    Abstract: This book focuses on new and innovative spatial approaches based on smart solutions and developed in the field of geography and related interdisciplinary fields such as urban and regional studies, landscape ecology and ecosystem services. It includes contributions from a conference dedicated to the 100th anniversary of the Bulgarian Geographical Society. In turn, the book reveals how 21st-century geography is expected to facilitate the development of human capital and the knowledge society, while also offering place-specific solutions for sustainable regional development and utilization of the planet’s natural and human capital to improve social wellbeing. This volume is intended for the global geographical research community, as well as professionals and practitioners in all fields that deal with space, including regional planners and environmental managers.
    Type of Medium: Online Resource
    Pages: VIII, 455 p. 141 illus., 113 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030281915
    Series Statement: Key Challenges in Geography, EUROGEO Book Series,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Geographic information systems. ; Quality of life. ; Regional economics. ; Spatial economics. ; Sociology, Urban. ; Geography. ; Geographical Information System. ; Quality of Life Research. ; Regional and Spatial Economics. ; Urban Sociology.
    Description / Table of Contents: Chapter 1-Land use and land cover change: advancing with geographic information science -- Chapter 2-Land use in Ontario: challenges in land use classification -- Chapter 3-The golden horseshoe: land use from past to present -- Chapter 4-First nations reserves in Ontario: effects of urban sprawl -- Chapter 5-Archaeological heritage and urban sprawl: corridors of change -- Chapter 6-The cityscape: urban growth in Toronto -- Chapter 7-Land use and health perception -- Chapter 8-Environmental injustice in southern Ontario -- Chapter 9-Happiness and land use. .
    Abstract: This book presents a systematic analysis of challenges in the field of Geographical Information Systems and Science, geographical analysis, and regional science for Ontario, one of the fastest-changing provinces in Canada and one of North America's largest economic hubs. In nine chapters, the book offers advanced spatial analysis techniques and digital data content to integrate Geographic Information Systems (GIS) as tools to tackle regional and urban challenges. The chapters address the following main topics: 1) state-of-the-art approaches for regional discrepancies, 2) investigations of available methods for advanced spatial analysis, 3) identification of regional patterns and land use dynamics, 4) availability of Web 3.0 data content for regions without standardized data, and 5) the limitations and challenges of urbanization and its impact on landscape, heritage and ecosystems. The volume is divided into four sections dealing with key issues in Ontario, each addressing the use of GIS for crucial regional decision-making. The book will be of interest to researchers, undergraduate and graduate students, planners, regional scientists, and policy makers.
    Type of Medium: Online Resource
    Pages: IX, 240 p. 66 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031247316
    Series Statement: Advances in Geographic Information Science,
    DDC: 910
    Language: English
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    Keywords: Environmental geography. ; Human geography. ; Urban policy. ; Sociology, Urban. ; Integrated Geography. ; Human Geography. ; Urban Policy. ; Urban Sociology.
    Description / Table of Contents: Cramped spaces, w(r)iggle room and everyday politics: An introduction -- Part 1: Everyday geographies of scholar activism -- Should I stay or should I go? Academic tempered radicalism in the era of ecological crisis -- Towards ‘minor’ methodologies or crisis as method -- Part 2: Repertoires of research methodologies and fieldwork experiences -- The sympoietic orchard: Everyday ways of co-creating an orchard -- Researching urban coworking spaces: Everyday life and reflexivity during the fieldwork -- Beyond the club: A feminist poetic inquiry to reimagine festive spaces and practices of the electronic scene in Paris -- Mapping sifikile – A place of home: Methodological reflections on hope from a coal frontier -- Madame Ruetabaga’s prefigurative politics at the urban fringes of Grenoble -- Digital practices on social media: New perspectives on the production of space and geopolitical inquiry -- Part 3: Embodied negotiations: Agency, survival, care -- Life at the margins: Women’s everyday practices as resistance in a working-class neighbourhood in Barcelona -- Digitalisation of working space: Women working from home in Turkey -- Home, work and everyday life: Gender dynamics in a mining city -- Epilogue.
    Abstract: The book provides a critical analysis of the geographies of everyday life, looking at how spatial practices craft w(r)iggle room to cope with the boundaries saturated by normativity, power relations, and inequalities. It explores the possibilities for making do with the everyday practices forming a way of living in cramped spaces. In this respect, early-career researchers and activists share their fieldwork experiences through an intersectional lens based on emerging research methodologies and scholar-activist practices. From their own vantage point, they look at their own contexts, practices, and research subjects at the level of everyday life. Spatial practices and place-based imaginaries from France, Finland, and Spain to Turkey and South Africa present a wide range of non-counter hegemonic yet enabling practices for transformation in everyday life. The contributors, trained in a variety of convergent disciplines concerned with everyday life and space (geography, geopolitics, architecture, urban planning, sociology, political sciences), discuss scholar-activist methodologies during the current crisis in contemporary academia, reflect on their research methodologies and research experiences, and inquire into the ways of embodied negotiations for agency, survival, and care. A group of early-career researchers and activists came together to seek out the possibilities of transformative change in everyday life during the peak periods of COVID-19. When researchers and activists were forced to stay at home in isolation, the authors met up online to discuss their subjectivities self-reflexively to challenge the distance between the researcher and “the field.” The book is the outcome of their collective production based on numerous meetings, writing workshops, and creative debates.
    Type of Medium: Online Resource
    Pages: XIV, 224 p. 23 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031465802
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geography. ; Landscape architecture. ; Landscape ecology. ; Geography. ; Landscape Architecture. ; Landscape Ecology.
    Description / Table of Contents: The logic of landscape pattern language -- The theoretical evolution and innovation of landscape pattern language -- landscape space units as the foundation of pattern language -- The C-3P analytical framework of landscape space -- The framework of landscape pattern language -- The space and design vocabulary of landscape pattern language -- spatial relations and reasoning of landscape pattern language -- Networks syntax and scaling of landscape pattern language -- Prospect of landscape pattern language using in practice.
    Abstract: This book presents a landscape pattern language framework for describing landscape spaces and offers a new approach to landscape expression and spatial reasoning. In addition to describing a conceptual model of landscape pattern language and its inner logical connections, the book discusses the functionality of landscape pattern language from both local and universal perspectives—effectively demonstrating that it can be used to highlight the individuality and characteristics of landscape space shaping. Given its scope, the book offers a valuable resource for all graduate students, lecturers, researchers, and practitioners in the areas of landscape architecture, landscape planning, and regional planning, especially ecological planning and design. .
    Type of Medium: Online Resource
    Pages: XXXIV, 422 p. 295 illus., 166 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811964305
    Series Statement: EcoWISE, Innovative Approaches to Socio-Ecological Sustainability,
    DDC: 910
    Language: English
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  • 74
    Keywords: Environmental geography. ; Climatology. ; Sociology, Urban. ; Economic development. ; Geography. ; Integrated Geography. ; Climate Sciences. ; Urban Sociology. ; Development Studies. ; Regional Geography.
    Description / Table of Contents: Systems Approach for Climate Change Impacts on Urban Health: Conceptual Framework, Modeling and Practice -- “SITE” (Societal-Institutional-Technical-Economic) Valuation framework : A case of drinking water facilities and services in slum areas of Hyderabad region -- Inequalities in access to water and sanitation: a case of slums in major states of India -- Chennai floods 2005, 2015: vulnerability, risk and climate change -- An environmental study of solid waste management system in of Chandrapur city, Maharashtra, India -- Linkages between Purdah Practice, Women Autonomy and Their Health Beliefs in India -- Development of urban heat island and its relation to heat waves -- Growing urbanization, health infrastructure and vector-borne diseases: A study in Khammam municipal corporation, Telangana state -- Maternal Reproductive Health: A Comparison between India and Empowered Action Group States -- Research Frontiers in Water, Environment and Human Health -- Impacts of resource consumption and waste generation on environment and its impact on human health: A study based on ecological footprint analysis -- The Impact Of Climate Change On Human Eyes -- Health and Well-being of Ageing Population in India: A Case Study of Kolkata -- Noise pollution and its consequences on urban health in Sylhet city -- Health Scenario in Delhi – Status and Recent Trends of Vector Borne and Water Borne Diseases in NCT of Delhi -- Quality of living, health and wellbeing of slum dwelling women domestic workers in Kolkata -- Urban Growth and Environment and Health Hazards in Kathmandu Valley, Nepal -- Impact of Urbanisation on Megacities’ Lakes Using Remote Sensing Technique – A Case Study of Water Quality Analysis in Ambattur Lake, Chennai, India -- Impacts of urbanization of ground water pollution – an emerging issue and some suggestions -- Evaluation of mass rapid transit system : A case study of Delhi -- The first survey of flood disaster Preparedness in Hanoi, Vietnam -- Tradition meets innovation: Herbal medicine as a sustainable source of anticancer agents -- Urban Health Infrastructure in Small Cities: Is it Availability or Accessibility? -- An approach to social sustainability in Chennai – understanding the dynamics of public places -- Water scarcity in Delhi: Mapping for solutions and the way forward. .
    Abstract: This book focuses on understanding urban vulnerability and risk mitigation, advancing good health and wellbeing, and analysing resilience measures for various Asian cities. Today, cities are the dominant human habitat, where a large number of environmental, social, cultural and economic factors have impacts on human health and wellbeing. Cities consist of complex, dynamic, socio-ecological, and technological systems that serve multiple functions in human health and wellbeing. Currently half of Asia’s population is urban, and that figure is expected to rise to 66 percent by 2050. Since urban areas are often most vulnerable to hazards, the people living in them need good health infrastructure facilities and technological support at various scales. As such, the need of the hour is to enhance the adaptive capacity, strengthen resilience, reduce vulnerability, and take risk mitigation measures in urban areas, which requires a systematic approach based on science–policy interface that is transformative, trans-disciplinary and integrative for a sustainable urban future. Global sustainable development goals are closely tied to urban human health and wellbeing: (1) the third of the United Nations’ Sustainable Development Goals is to “Ensure healthy lives and promote wellbeing for all at all ages” and (2) the eleventh is to “Make cities inclusive, safe, resilient and sustainable”. By addressing these goals, this book offers a highly useful resource for anyone concerned with healthy and resilient cities in Asia, today and tomorrow.
    Type of Medium: Online Resource
    Pages: IX, 459 p. 124 illus., 103 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811512056
    Series Statement: Advances in Geographical and Environmental Sciences,
    DDC: 910
    Language: English
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  • 75
    Keywords: Geography. ; Digital humanities. ; Open source software. ; Sustainability. ; Cartography. ; Geography. ; Digital Humanities. ; Open Source. ; Sustainability. ; Cartography.
    Description / Table of Contents: Chapter1. Introduction -- PartI. Mapping for the Goals on Poverty, Hunger, Health, Education, Gender, Water, and Energy -- Chapter2. Open Data Addressing Challenges Associated with Informal Settlements in the Global South -- Chapter3. Leveraging Spatial Technology for Agricultural Intensification to Address Hunger in Ghana -- Chapter4. Rural Household Food Insecurity and Child Malnutrition in Northern Ghana -- Chapter5. Where is the Closest Health Clinic? YouthMappers map their communities before and during the COVID-19 pandemic -- Chapter6. Cross-continental YouthMappers Action to Fight Schistosomiasis Transmission in Senegal -- Chapter7. Understanding YouthMappers Contributions to Building Resilient Communities in Asia -- Chapter8. Activating Education for Sustainable Development Goals through YouthMappers -- Chapter9. Seeing the World Through Maps: An Inclusive and Youth Oriented Approach -- Chapter10. Youth Engagement and the Water-Energy-Land Nexus in Costa Rica -- Chapter11. Power Grid Mapping in West Africa -- Chapter12. Mapping Access to Electricity in Urban and Rural Nigeria -- PartII. Youth Action on Work, Leadership, Innovation, Inequality, Cities, Production and Land -- Chapter13. Stories from Students Building Sustainability Through Transfer of Leadership -- Chapter14. Drones For Good: Mapping Out the SDGs Using Innovative Technology in Malawi -- Chapter15. Assessing YouthMappers Contributions to the Generation of Open Geospatial Data in Africa -- Chapter16. Mapping Invisible and Inaccessible Areas of Brazilian Cities to Reduce Inequalities -- Chapter17. Visualizing YouthMappers Contributions to Environmental Resilience in Latin America -- PartIII. Marking a Path to Goals on Sustainable Communities, Consumption, Climate, Oceans, Land, and Justice -- Chapter18. Youth Engagement and Participation in Mitigating Perennial Flooding in Kampala, Uganda using Open Geospatial Data -- Chapter19. Sustainable Mobility through Knowledge Exchange and Collaborative Mapping of Cycling Infrastructure: SIGenBici in Medellín, Colombia -- Chapter20. Wastesites.io: Mapping Solid Waste to Meet Sustainable Development Goals -- Chapter21. Mapping for Resilience: Extreme Heat Deaths and Mobile Homes in Arizona -- Chapter22. Mapping for Women’s Evacuation Plans during Climate-induced Disasters -- Chapter23. Sustainable Development in Oceania and the Role of Mapping for Women -- Chapter24. Sustainable Coastal Communities in the Anthropocene: Lessons from Crowd-Mapping Projects in Colombia -- Chapter25. Collaborative Cartography Making Riparian Communities Visible in Tefé, Amazonas, Brazil -- Chapter26. Open Mapping with Official Cartographies in the Americas -- Chapter27. Cities of the Future Need to be Both Smart and Just: How We Think Open Mapping Can Help -- PartIV. Supporting YouthMappers to Advance the SDGs through Institutions and Partnerships -- Chapter28. Mentoring Experiences in YouthMappers Chapters -- Chapter29. The Ecosystem Where YouthMappers Live and Thrive -- Chapter30. A Free and Open Map of the Entire World: Opportunities for YouthMappers within the Unusual Partnership Model of OpenStreetMap -- Chapter31. Youth and Humanitarian Action: Open Mapping Partnerships for Disaster Response and the SDGs -- PartV. The Paths Ahead -- Chapter32. Generation 2030: The Strategic Imperative of Youth Civic and Political Engagement -- Chapter33. Reflecting on the YouthMappers Movement.
    Abstract: This collection amplifies the experiences of some of the world’s young people who are working to address SDGs using geospatial technologies and multi-national collaboration. Authors from every region of the world who have emerged as leaders in the YouthMappers movement share their perspectives and knowledge in an accessible and peer-friendly format. YouthMappers are university students who create and use open mapping for development and humanitarian purposes. Their work leverages digital innovations - both geospatial platforms and communications technologies - to answer the call for leadership to address sustainability challenges. The book conveys a sense of robust knowledge emerging from formal studies or informal academic experiences - in the first-person voices of students and recent graduates who are at the forefront of creating a new map of the world. YouthMappers use OpenStreetMap as the foundational sharing mechanism for creating data together. Authors impart the way they are learning about themselves, about each other, about the world. They are developing technology skills, and simultaneously teaching the rest of the world about the potential contributions of a highly connected generation of emerging world leaders for the SDGs. The book is timely, in that it captures a pivotal moment in the trajectory of the YouthMappers movement’s ability to share emerging expertise, and one that coincides with a pivotal moment in the geopolitical history of planet earth whose inhabitants need to hear from them. Most volumes that cover the topic of sustainability in terms of youth development are written by non-youth authors. Moreover, most are written by non-majoritarian, entrenched academic scholars. This book instead puts forward the diverse voices of students and recent graduates in countries where YouthMappers works, all over the world. Authors cover topics that range from water, agriculture, food, to waste, education, gender, climate action and disasters from their own eyes in working with data, mapping, and humanitarian action, often working across national boundaries and across continents. To inspire readers with their insights, the chapters are mapped to the United Nations 17 Sustainable Development Goals (SDGs) in ways that connect a youth agenda to a global agenda. This is an open access book. .
    Type of Medium: Online Resource
    Pages: XXIII, 382 p. 258 illus., 251 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031051821
    Series Statement: Sustainable Development Goals Series,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Buildings Design and construction. ; Regional economics. ; Spatial economics. ; Sociology, Urban. ; Landscape architecture. ; Geomorphology. ; Geography. ; Building Construction and Design. ; Regional and Spatial Economics. ; Urban Sociology. ; Landscape Architecture. ; Geomorphology.
    Description / Table of Contents: Chapter 1 - Methodological introduction, research structure & state of the art -- Chapter 2 - Suburban shopping mall as Urban Fabric -- Chapter 3 - Suburban commercial fabric formative process -- Chapter 4 - Retail spaces Crisis and Future transformative process -- Chapter 5 – Conclusions -- Bibliography.
    Abstract: This book derives from observations of the contemporary built environment and its contradictions. The suburban retail spaces, specifically the suburban shopping mall, and the changes caused by them within urban organisms are the object of the investigation synthesized in the volume. The topic is very crucial for the development of the contemporary city. It constitutes at the same time a problem (large commercial structures' spread is 'destroying' traditional commercial urban fabrics) and an opportunity (shopping malls are the most vital parts of the new suburbs and can play the role of community nucleus in urban and suburban areas). Furthermore, the spread of e-commerce forces these structures to functional and spatial transformations that brings also a new relationship with the city. The analytical reading, supplemented by generative and design projections, is carried out by using the conceptual and methodological tools of urban morphology, specifically those of the typological processual approach. From this specific point of view, the suburban shopping mall is read as an organism (a complex system characterized by mutual solidarity and interdependence among component elements) in itself, and as a sub-organisms belonging to the largest territorial organism. The book is intended to offer, to operators, scholars, researchers, professionals and students, a reading and design method, to interpret an important aspect of the contemporary built environment by analyzing the suburban commercial space case. It offers at the same time a model applicable to other specific not-commercial cases, to defining paths for further research and design developments.
    Type of Medium: Online Resource
    Pages: XI, 96 p. 30 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030549916
    Series Statement: SpringerBriefs in Geography,
    DDC: 910
    Language: English
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  • 77
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Geographic information systems. ; Peace. ; Geography. ; Geographical Information System. ; Peace and Conflict Studies.
    Description / Table of Contents: Part1. Sources, impacts, and the perspectives on resource conflicts -- Chapter1. Natural Resources, Conflict of Interests and their Management -- Chapter2. Sources, Impacts and Management of Natural Resources Conflicts -- Chapter3. Perspectives on Natural Resource Conflicts -- Part2. Participatory Mapping and PGIS applications in conflict management -- Chapter4. Participatory Mapping and management of natural resource conflicts -- Chapter5. The Development of Community-based GIS Applications -- Chapter6. The impact of geospatial data processing on conflict-supporting beliefs -- Chapter7. Case study: Participatory mapping and management of conflict of interests over allocation of resources within the Aboma Forest Reserve at Kofiase, Ghana -- Part3. Assessment of Participatory Mapping and PGIS applications in conflict management -- Chapter8. Important factors in successful Participatory Mapping and PGIS applications in conflict management -- Chapter9. Appraisal of the roles of Participatory Mapping and PGIS applications in conflict management -- Chapter10. Conclusion.
    Abstract: This book integrates spatial analysis into the study and management of conflicts, and offers a model in conflict studies that incorporates theoretical explanations of conflict, its causes, and impacts, with a geospatial strategy for intervening in disputes over allocation and use of natural resources (connects theory and practice). Alongside a theoretical analysis of resource conflicts and an account of Participatory Mapping and PGIS development, this book provides a case study of GIS applications in conflict mediation. The book also lays out a practical and straightforward demonstration of PGIS applications in conflict management using a real-world case study, and traces the Participatory Mapping and PGIS movements’ evolution, compares PPGIS and PGIS practices, and makes distinctions between traditional GIS applications and PGIS practice. The approach embodies the enhanced use of spatial information and media, sets of tools for analyzing, mapping, and displaying spatial data and a platform for participatory discussions that enhances consensus-building. The book, therefore, contributes to the search for novel approaches for managing current and emerging conflicts. With this book, resource managers, development practitioners, students, and scholars of Participatory Mapping and PGIS applications and conflict studies will be equipped with the principles, skills, and the tools they need to manage non-violent resource conflicts and keep the disputes from slipping into violence. The book will also be a valuable text for basic and advanced studies in Participatory Mapping and PGIS applications, Conflict Resolution and Conflict Management. .
    Type of Medium: Online Resource
    Pages: XXVI, 234 p. 11 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030741662
    DDC: 910
    Language: English
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    Keywords: Geography. ; Ecology . ; Geomorphology. ; Climatology. ; Biodiversity. ; Geography. ; Ecology. ; Geomorphology. ; Climate Sciences. ; Biodiversity.
    Description / Table of Contents: Geographic Uniqueness of the Sierra Nevada in the Context of the Mid-latitude Mountains -- Biotic Uniqueness of the Sierra Nevada as a Hotspot of Biodiversity -- Singular Cultural Landscapes of the Sierra Nevada -- Scientific Knowledge Generated in the Sierra Nevada: Bibliographic Review in WOS Since 1970 -- The Geological Setting -- Glacial Geomorphology of the Massif -- Reconstruction of Past Environments Using Lake Sedimentary Records -- Modern Periglacial Environment and Permafrost -- Variability and Recent Trends -- Snow Dynamics, Hydrology and Erosion -- Altitudinal Migrations and Changes in the Composition of High Mountain Plant Communities -- Altitudinal Migrations and Changes in the Composition of Animal Communities -- Dynamics of Forest Systems Under Land Use and Climatic Change Scenarios -- Resilience of Montane Ecosystems to Major Disturbances (fires) -- Migrations Rivers -- High Mountain Lakes as Remote Sensors of Global Change -- Paleolimnological Indicators of Climate Change -- Atmospheric Inputs and Drastic Alterations in Food Webs and Ecosystems Processes -- Remote Sensors Monitoring of Functional Aspects of Terrestrial and Aquatic Ecosystems -- Managing the Uniqueness of Sierra Nevada Ecosystems Under Global Change: Adaptive Projects -- Incorporation of Traditional Knowledge in Agrobiodiversity for a Sustainable Mountain Economy -- Data Model, E-infrastructure Services and Virtual Research Environments (VRE) -- Advancing Open Science in Sierra Nevada: Current Citizen Science Campaigns -- Filling the Gaps in Research, Management and Social Connection.
    Abstract: This book covers the landscape, geography and environment of the Sierra Nevada in Spain. The Sierra Nevada hosted the last glaciers in southern Europe. Today, it is one of the most important centers of plant diversity in the western Mediterranean and one of the most outstanding in Europe. This massif has ideal conditions to analyze past environments as well as the effects of global change on ecosystems. This can be seen in the large number of projects that are being conducted within the umbrella of the Sierra Nevada Global Change Observatory. This book summarizes all the scientific knowledge available about this massif, from the geomorphological and ecological perspectives to the recent spatial adaptive management and Open Science initiatives. Focusing on the very sensitive mountain environment of Sierra Nevada, the book intends to be a reference for many people interested in mountain processes. The audience would include scientists from all disciplines, but it would also target on an audience beyond the academia (territorial managers, environmentalists, mountaineers, politicians, technicians, etc.).
    Type of Medium: Online Resource
    Pages: XVII, 421 p. 171 illus., 156 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030942199
    DDC: 910
    Language: English
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    Keywords: Geography. ; Teaching. ; Human geography. ; Critical Thinking. ; Geography. ; Pedagogy. ; Human Geography. ; Critical Thinking.
    Description / Table of Contents: Chapter 1-The wonderment of touching, sensing and naming the more-than human world -- Chapter 2-Being in and through aesthetic forms of expressions reimagining a future world -- Chapter 3-Awareness and subjectification of the more-than-human world -- Chapter 4-Exploring the world in sensuous ways, creating new narratives and asking urgent and severe questions -- Chapter 5-Social Justice and Action Competences in Classroom Practice: The future ‘skills’ of citizenship -- Chapter 6-Introducing disorienting dilemmas: Provoking actions -- Chapter 7-Creating spaces for negotiation, imagining and listening: Stretching situated moments of critical literacy in whole class discussion -- Chapter 8-Addressing anxiety: To linger, confirm and give hope -- Chapter 9-Transformative learning: Creating new identities -- Chapter 10-Take a stance: Facilitating students’ decision-making.
    Abstract: This volume focuses on the fourth Sustainable Development Goal (SDG), education, to look at sustainability from various angles with the purpose of challenging preconceptions about what sustainable education might entail and how it should be conducted. To this end, the book assembles scholars from various research fields and disciplines, who are willing to be at the cutting edge regarding sustainability and education on all levels with students in the ages of 6-15. Through this approach, the text points towards a “wild pedagogy” in line with post-sustainable thinking. This involves agency and the role of nature itself as a co-educator, and promotes cultural changes, and explorative processes of finding “the wild” – the unknown, and complexity in nature – and thus of challenging the human need for control. This approach is also, in line with the 2030 Agenda, an attempt to move from advocating predetermined behavioural change to embracing a pluralistic perspective on sustainability, based on holistic views on education. Such views include curiosity, wonderment, compassion and agency as guiding lights. The book is structured into three sections, based on three interrelated strands. These strands are, in various ways, dependent on one another and further engaged with bringing education theory and practice together. These strands are 1) Belonging and sensing, 2) Critical thinking, social justice and action competence, and 3) Creating hope in a vanishing world. These strands aim to increase our access to and understanding of the ways in which sustainability can be integrated into education and why. The purpose of the text is to encourage educators of all kinds and levels, as well as scholars in different fields, to explore new perspectives on education for sustainable development. The book examines probes in diverse academic fields and focuses on how to combine different approaches and content, and therefore everyone interested in interdisciplinary and cross-curricular teaching and learning should find this work enlightening. .
    Type of Medium: Online Resource
    Pages: XXVII, 186 p. 42 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030845100
    Series Statement: Sustainable Development Goals Series,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Medical care. ; Human geography. ; Integrated Geography. ; Health Care. ; Human Geography.
    Description / Table of Contents: 1-Adolescent Mental Health in the MENA Region and the link with Policy and Programming -- 2-There is no Health Without Mental Health: The Middle East and North Africa -- 3-A Silent Epidemic of Depression among Adolescents in the Middle East and North Africa Region: Emerging Tribulation -- 4-Understanding mental illness stigma in Arab youths’ everyday lives -- 5-Developing and Implementing Youth Friendly Public Policies: A perspective into the Arab Region -- 6-Adolescent health in Saudi Arabia: Policy dimensions -- 7-Health Policies of Adolescents in the Middle East and North Africa: What Works, What Doesn’t, and How Do We Strategize in the Age COVID-19?.
    Abstract: This 2-volume set focuses on adolescent health in the Middle East and North Africa region (MENA), and presents the latest research on the health risk behaviours and social behaviours that adolescents from the MENA region engage in. While there has been a surge in peer-reviewed research publications on population health in the MENA region in the last couple of decades, very few books offer a resource to address the diverse negative influences that disproportionately affect adolescents and children in the MENA region, including increased tobacco consumption culture, low emphasis on physical activity, increased sedentary behaviours, weak health policies, and societal issues related to displacement and political conflicts. These books offer a synthesis of current knowledge on adolescent health issues in the MENA region, and aim to provide evidence-informed adolescent health care practices that address current issues related to mental, physical, reproductive and nutritional health. Volume 1 focuses on mental health in the MENA region, the development and implementation of youth friendly public policies, and how to strategize in the age of COVID-19. The study will aid health care professionals, policy makers, government organizations and health program planners to assess current policies and practices related to adolescent health in the MENA region, and to identify the best courses of action moving forward. .
    Type of Medium: Online Resource
    Pages: X, 121 p. 5 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030917906
    Series Statement: Global Perspectives on Health Geography,
    DDC: 910
    Language: English
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  • 81
    Keywords: Geography. ; Sustainable architecture. ; Urban ecology (Biology). ; Buildings Design and construction. ; Restoration Ecology. ; Geography. ; Sustainable Architecture/Green Buildings. ; Urban Ecology. ; Building Construction and Design. ; Restoration Ecology.
    Description / Table of Contents: Chapter 1 -- Study on Mechanism of Climate Response and Ecological Restoration in High Density Urban Area. Chapter 2 -- Ecological Process and Security under the Intensification of Urban Agglomeration Development. Chapter 3 -- Seoul Botanic Park, Inventing New Type of Sustainable Park. Chapter 4 -- Ecological Restoration Design Integrated with City Life. Chapter 5 -- Solar Power Singapore. Chapter 6 -- Research on Practical Application of Healthy Building in South China. Chapter 7 -- Performance-based Evaluation on Biophilic Design Qualities of Outdoor Spaces: BUCEA Campus as a Case Study. Chapter 8 -- Current Status of Artificial Intelligence in Smart Home – From Literature and Product. Chapter 9 -- Consideration of Sustainable Design. Chapter 10 -- Automatic Generation of 3D House Models with Solar Photovoltaic Generation. Chapter 11 -- Performance-driven Design Methods of Building Shape: Investigations based on Acoustics and Daylight. Chapter 12 -- Design and Climate-Responsiveness Performance Evaluation of an Integrated Envelope for Modular Prefabricated Buildings. Chapter 13 -- Meso-scale Urban Environmental Performance Evaluation in High Density Urban Context. Chapter 14 -- The Passive in Singapore: Revolution of Green Building Rating System.
    Abstract: This volume discusses the climate responsiveness of sustainable architecture design and technology in China, Japan, Singapore, and South Korea in recent years, addressing concepts and applications in urban planning, building design, and structural performance evaluation. The four sections of the text cover the theory and implementation of sustainable architecture within various geographic boundaries and contexts, offering an interdisciplinary assessment of the challenges faced in urban areas at different climate zones. The main topics covered are: 1) urban ecological restoration under the influence of climate environment; 2) health and human considerations of building and environment; 3) prototype optimization of sustainable building, and 4) feedback of building performance and design evaluation. The book is intended to be a contribution to the growing body of knowledge on sustainable architecture for applicable use by practitioners, city planners, field researchers, and building operators in building design, construction, usage, operation, and maintenance.
    Type of Medium: Online Resource
    Pages: VIII, 245 p. 113 illus., 83 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030800345
    Series Statement: Spatial Planning and Sustainable Development,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Landscape architecture. ; Landscape ecology. ; Urban ecology (Biology). ; Geography. ; Landscape Architecture. ; Landscape Ecology. ; Urban Ecology.
    Description / Table of Contents: Chapter1. Introduction and Methodology -- Chapter2. Ancient Indian Design and Town Planning Principles as a Frame for Case Studies -- Chapter3. Other Interpretive Frameworks -- Chapter4. Shiva Temples -- Chapter5. Deliberations.
    Abstract: Classic Indian texts and Vaastupurusha Mandala are not often discussed in the western discourse on urbanism, even while much of these predate the commonly taught European writings. This book sheds light on some of those forgotten concepts, thus making the lesser discussed classic Indian town organization ideas accessible to architecture, landscape, and urban planning students worldwide. The resonance of these concepts in present times are reviewed through case studies of select Hindu temple towns in India. Furthermore, the author underscores the formal abstraction of the classic Indian Mandala and transplants the discourse from sociology to socio-ecologically adept trans-disciplinary design thinking. The creative interpretations offer a premise to start revising classic models for current practice to influence the urbanism and ecology of a place in accordance with the changing climate. Reviews “India has a strongly developed design, planning language and principles or sutras as shared through ancient Indian texts approximately developed through 5000-550 BCE such as, Kamikagama and Suprabhedgama, Matsyapurana, Bhavishyapurana, and Manasara. Kautilyashastra from around 5th BCE builds additional layers of complexity to the discourse. Sharma’s book orients the students to some of these classic ancient principles while taking them on an investigative journey of applicability of these at temple precinct and town level.” - Pankaj Jain. Professor and Head of the Department of Humanities and Languages, FLAME University, Pune, India “Our changing climate is forcing the rapid evolution of the pressing issues concerning urbanism. Sharma’s book draws upon traditional Indian frameworks to be embedded in design methods, to creatively mitigate the current problems to be addressed in urbanism.” -Tom Verebes. Professor of Architecture, New York Institute of Technology "Dr. Sharma presents an enlightening and groundbreaking perspective on the Hindu Temple landscape, placing it in the nexus of urbanism and ecology." - Diane Jones Allen, Professor of Landscape Architecture, University of Texas at Arlington.
    Type of Medium: Online Resource
    Pages: XIII, 112 p. 106 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030872854
    DDC: 910
    Language: English
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    Keywords: Environmental geography. ; Urban ecology (Biology). ; Sustainable architecture. ; Landscape architecture. ; Landscape ecology. ; Integrated Geography. ; Urban Ecology. ; Sustainable Architecture/Green Buildings. ; Landscape Architecture. ; Landscape Ecology.
    Description / Table of Contents: Part I. The Green City: General Concept -- Chapter 1. What Does “The Green City” Mean?(Jürgen Breuste) -- Chapter 2. What Is Urban Nature? (Jürgen Breuste) -- Chapter 3. What is Urban Green and Blue Infrastructure? (Jürgen Breuste) -- Chapter 4. The Green City: General Concept (Jürgen Breuste) -- Part II. The Nature Concept – of What Urban Green Nature Consists of Part Front Matter -- Chapter 5. The Four Urban Natures Approach (Jürgen Breuste) -- Chapter 6. Urban Woodlands - Remnants of Pristine Landscape (Jürgen Breuste) -- Chapter 7. Public Urban Parks - Designed Urban Green Spaces (Jürgen Breuste) -- Chapter 8. Urban Gardens – The Private Urban Green (Jürgen Breuste) -- Chapter 9. Urban Waters – The Urban Blue Infrastructure (Jürgen Breuste) -- Chapter 10. New Urban Wildernesses - Novel Urban Ecosystems (Jürgen Breuste).
    Abstract: This book shows what role nature can play in a city and how this can make it a better place for people to live. People, planners, designers and politicians are working towards the development of green cities. Some cities are already promoted as green cities, while others are on their way to become one. But their goals are often unclear and can include different facets. Presenting contributions from world leading researchers in the field of urban ecology, the editors provide an interdisciplinary overview of best practices and challenges in creating green cities. They show examples of how to build up these cities from bits and pieces to districts and urban extensions. Each example concludes with a summary of the collected knowledge, the learning points and how this can be used in other places. The best practices are collected from around the world – Europe, America and Asia. Contributions cover a wide range of biophysical and cultural backgrounds within these three continents, including the Central, Southern and Eastern European region, as well as Latin and North America. The new dynamic urban development of Asia is illustrated by case studies from China and the Indian subcontinent. The reader will learn which role nature can play in green cities and what the basic requirements are in terms of culture, pre-existing nature conditions, existing urban surroundings, history, design and planning.
    Type of Medium: Online Resource
    Pages: XX, 595 p. 201 illus., 171 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783030730895
    Series Statement: Cities and Nature,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Geography.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Framework -- Chapter 3. Case study -- Chapter 4. Discussion -- Chapter 5. Conclusions -- Appendices.
    Abstract: This book provides a multidisciplinary approach for the study of the “abandonment” problem at the inter-section among urban studies, neo-institutionalist perspectives, and social ontology. An analytical framework (based on descriptive and operational issues, factors, reasons, policies) has been built to interpret the phenomenon of abandonment and possible ways of intervening. The work considers the Italian situation in general terms and examines the case study of Milan in depth. This case is interesting because it triggered public discussions on the problem of abandonment in a non-shrinking context. Moreover, recently, specific policies to cope with abandonment problem have been introduced. The purpose of the book is to show that the problem of the “abandonment” of urban buildings should be understood as a social fact and not as a brute fact. Thus, in this work the “abandoned” state of buildings is considered as not directly related to certain physical variables; rather, it entirely depends on human evaluations. Crucial information in this regard is how institutional frameworks (e.g. sets of rules of conduct) influence individual behaviour and actions through time. In this view, we may identify abandonment as a phenomenon intertwined with the actions of both private and public entities. The neo-institutional approach helps to highlight how the problem of abandonment is articulated with respect to property rights, formal constraints, reasons behind policy decisions, intervention strategies and implementations.
    Type of Medium: Online Resource
    Pages: VI, 89 p. 19 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030903671
    Series Statement: SpringerBriefs in Geography,
    DDC: 910
    Language: English
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  • 85
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Architecture. ; Materials science. ; Bioclimatology. ; Climatology. ; Geography. ; Architecture. ; Materials Science. ; Climate Change Ecology. ; Climate Sciences.
    Description / Table of Contents: Introduction -- Chapter 1. BauKlima/ BuildingClimate -- Chapter 2. BauStoff/ Building Matters -- Chapter 3. KlimaStoff/ (Future) Climate Matters -- Bibliography.
    Abstract: This book examines prospective climate adaptive building materials in desert and drylands in the context of climate change, desertification, urbanisation demands, and the consequent sustainable urban development challenges. This preliminary collection of ecological materials covers the characterisation of biotic and abiotic resources for materials, their specifications and benefits for adequate bio-climatic design and construction. Particular emphasis is given to ecological composite materials for advances in desert architecture. Based on the initial collection, the book culminates with potentials for new ecological building materials. The "eComposite Combinator" matrix offers potential research recipes and encourages the reader to conduct further climate-matters related research.
    Type of Medium: Online Resource
    Pages: XIII, 134 p. 26 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030954567
    Series Statement: SpringerBriefs in Geography,
    DDC: 910
    Language: English
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  • 86
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Cities and towns History. ; Sociology, Urban. ; Political science. ; Geography. ; Urban History. ; Urban Sociology. ; Political Science.
    Description / Table of Contents: Introduction: Critical planning and design: Walking through roots and dissenting imaginations -- Part 1: Roots -- Giancarlo Paba’s trilogy of Luoghi comuni (Common Places, 1998), Movimenti urbani (Urban Movements, 2003), Corpi urbani (Urban Bodies, 2010): Influential Italian ‘critical planning’ thinking -- Ildefonso Cerdà, Teoría General de la Urbanización, 1867: An innovative approach -- L’Ordine politico della Comunità (The Political Order of Community) 2014: Concrete community and territorial principle in Adriano Olivetti’s thought -- All the layers of an ecological commitment at the frontier: Ian McHarg, Design with Nature, 1969 -- L' Architecture de survie (1978) is back talking to EU cities in crisis: The provocative message by Yona Friedman as a key for the present and future urban agenda -- Part 2: Planning pathways -- John Friedmann, The Good Society (1979): Panning pathways for a just society -- David Harvey’s Urbanization of Capital (1985): Why it helped me so much -- A place in the world? Places, Cultures and Globalization, 1995. Doreen Massey’s lessons: Is the world really shrinking or is the geography of the world teaching us openness and diversity? -- Patsy Healey and Collaborative Planning (2005): Re-thinking democracy in the ‘reasoning in public’ arena -- Utopian tension: Sandercock’s inspiring journey “Towards Cosmopolis” (1998) -- Zwischenstadt / Inbetween city. Thomas Sieverts, Cities Without Cities: An interpretation of the Zwischenstadt, 2004 -- Part 3: Conceptual frames -- Inquiry and change: The troubled attempt to understand and shape society, 1990: The radical contribution of Charles E. Lindblom’s self-guiding society and probing volitions -- Rediscussing Robert Nozick’s Anarchy, State and Utopia, 1974 -- Property titles to land and issues of distributive justice -- Blade Runner, 1982. Do Androids dream of electric sheep?- Philip K Dick’s science fiction and Maschinenmenschen in Metropolis -- Max Weber, Die Stadt (1922), English edition, Max Weber, The City, edited and traslated by Don Martindale and Gertrude Neuwirth, The Free Press, 1958 -- Antonio Gramsci and the prison notebooks -- Le droit à la ville, 1968: Reading Lefebvre’s the right to the city in planning perspective -- The trouble with Henri: The production of urban space – from theory to research -- Gilles Deleuze & Félix Guattari, Mille Plateaux, 1980: "The good use of philosophy" -- Georges Didi-Huberman, La survivance des lucioles (2009). The thickness of time: going beyond the surface of the present to understand contemporary territories.
    Abstract: The book interprets and recombines, within a subjective trajectory, some roots, pathways and conceptual frames of the planning thought that worked either as dissenting imaginations or generative source to critically question the modernist epistemologies. ‘Critical planning and design’ is presented in this book as a field of research inspired by critical urban theory and developed along with ideas and theories that prove to be radical, alternative, dialectical to the mainstream history of planning. In this book, scholars present what they consider as the most important books in the field of planning, public policy and design. They have been asked to write about a book and its author, in their preferred manner. This freedom allowed passionate and original contributions. Three main threads - the three parts of the book - shape the choices of the authors. The first concerns the reconstruction of some genealogical roots of planning (including Cerdà, Yona Friedman, Alberto Magnaghi, and Ian McHarg). The second thread groups the authors who dialogue with contemporary protagonists of the planning debate (including John Friedmann, Leonie Sandercock, Doreen Massey, David Harvey, Tom Sievert, and Patzy Healey). The third thread includes authors who dig into relevant writings in social and philosophical sciences (including Max Weber, Charles Lindblom, Henri Lefebvre, Gilles Deleuze & Félix Guattari, Georges Didi-Huberman, Robert Nozick, Pand hilip K Dick). The book is addressed to researchers of planning and urban studies, who value the critical re-reading of some fundamental books. Including thoughtful and critical arguments on influential thinkers of the past two centuries, the book will enable students, scholars and researchers of planning, design, political science, geographical, environmental, and urban studies to better understand the socio-spatial and ecological transformations under the contemporary transition while relying on a “usable past”. The book is also addressed to a wider audience of readers interested in the problems of the city and space.
    Type of Medium: Online Resource
    Pages: XX, 263 p. 8 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030931070
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 87
    Keywords: Geography. ; Earth sciences. ; Geography. ; Earth Sciences.
    Description / Table of Contents: 1 Challenging a static conception of Heimat -- 2 Heimat: theoretical framework(s) -- 3 Methodological approach -- 4 Insights from migrant biographies on the concept of Heimat -- 5 Heimat: an emotional map of biographical references -- 6 Conclusions on Heimat in the context of international migration.
    Abstract: The German notion of ‘Heimat’ is highly subjective, ambiguous and historically charged. Senses of belonging and identity associated with Heimat render the concept vulnerable to appropriation and instrumentalization by different political forces. Thereby, a static and exclusive understanding of Heimat is often depicted. This book drafts a counternarrative to demystify the contested concept. On the one hand, Heimat is conceptualized as spatial through emotional-geographical approaches to human-place relations. And on the other hand, the concept is placed in a global context through the perspective of international migration. The author contributes to the understanding of Heimat as an emotional map of self-location. This subjective map is neither purely static nor dynamic - it is characterized by simultaneities of opposing processes. About the Author Jessica Andel is currently enrolled in the Master’s programme “Human Geography: Globalisation, Media and Culture”. Since November 2019, she has been working as a student assistant on the Human Geography-team at the Institute of Geography of Johannes Gutenberg University.
    Type of Medium: Online Resource
    Pages: VI, 113 p. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783658389857
    Series Statement: BestMasters,
    DDC: 910
    Language: English
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  • 88
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Social sciences. ; Humanities. ; Veterinary medicine. ; Human geography. ; Cultural geography. ; Geography. ; Humanities and Social Sciences. ; Veterinary Science. ; Social and Cultural Geography.
    Description / Table of Contents: Chapter 1. Introduction: Roald Amundsen and the Sled Dogs -- Part 1: Hobart, Australia -- Chapter 2. All Aboard: The Departure from Antarctica -- Chapter 3. Leaving Antarctica: The Rough Journey Back -- Chapter 4. The Public Relations Machine Behind the Scenes -- Chapter 5. A Hero’s Welcome in Hobart -- Chapter 6. Fleeing the Journalists Whilst Courting the Press -- Chapter 7. Twenty-One Sledge Dogs for Douglas Mawson -- Chapter 8. A Tale of Two Fates: Roald Amundsen’s Victory and Robert Falcon Scott’s Tragedy -- Part 2: Buenos Aires, Argentina -- Chapter 9. The Captain and Mrs. Snuppesen -- Chapter 10. Arrivals and Departures: Buenos Aires, Norway, and Don Pedro Christophersen -- Chapter 11. The Dogs at the Buenos Aires Zoological Gardens -- Chapter 12. London Calling: Lord Curzon and the Royal Geographical Society -- Chapter 13. The Big Speech: The Cheer for the Dogs -- Chapter 14. Death and Deceit.
    Abstract: This book documents the return of the surviving sled dogs of the Norwegian Antarctic Expedition of 1910–1912 from Antarctica, where they had helped Roald Amundsen become the first human to reach the South Pole. This book is the sequel to the highly acclaimed Roald Amundsen’s Sled Dogs: The Sledge Dogs Who Helped Discover the South Pole. It chronicles how the sled dogs were used internationally to further promote the expedition’s great achievement and follows some of the dogs as they undertake subsequent expeditions – with Douglas Mawson’s Australasian Antarctic Expedition of 1911–1914, which made scientific discoveries, and with Arve Staxrud’s Norwegian Arctic Rescue Mission of 1913, which saved members of the Herbert Schröder-Stranz German Arctic Expedition. The book tracks the remaining 39 sled dogs to their next challenging adventures and their final destinations in Argentina, Norway, Antarctica, and Australia. Like its predecessor, the book portrays how Amundsen continued to utilize the Polar dogs – both in their lives and in their deaths – to propel his career and solidify his expedition's image.
    Type of Medium: Online Resource
    Pages: XXV, 467 p. 89 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030651138
    DDC: 910
    Language: English
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  • 89
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Urban policy. ; Climatology. ; Integrated Geography. ; Urban Policy. ; Climate Sciences.
    Description / Table of Contents: Governance of climate responsive cities: Scale matters!- Resilience, uncertainty and adaptive planning -- Barriers to implementing local climate action plans in Turkey: Searching for a potential way-out -- Exploring the Governance of Naples, Italy, through a climate responsive approach -- Community engagement in climate change policy: The case of three mills, East London -- Co-design of a nature-based solutions ecosystem for reactivating a peri-urban district in Quito, Ecuador -- How co-design of public space contributes to strengthening resilience: Lessons from two Chilean cases -- In-formal green infrastructure (IGI) and the pursuit of climate responsive environments in Quito City -- Co-designing local climate action: A methodological framework from a democratic perspective.
    Abstract: The book presents governance with a particular focus on the social and spatial aspects of climate responsiveness and reads the practice of governance across different scales. It conceptualizes a framework of scale composed of three main categories including (i) scientific knowledge, (ii) plans and policies, and (iii) authorities of action. This framework presents ‘practice’ as the social context in which these three can interplay adaptively. Within this framework, the book presents case studies from Turkey, Italy, Ecuador, Chile and the UK, that reach meaningful planning and design solutions at national, city, and neighbourhood scales in the face of climate change. It offers implementation clues that are transferable to ever-increasing climate action around the globe. The book will be of interest to both professionals and scholars involved in urban design, urban planning and architecture, especially those in the field of climate responsive urbanism. It will also be a valuable resource for non-governmental organizations and social enterprises dealing with sustainability and climate change policies.
    Type of Medium: Online Resource
    Pages: XIII, 164 p. 37 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030733995
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 90
    Keywords: Geography. ; Economic geography. ; International relations. ; Geography. ; Economic Geography. ; International Relations Theory.
    Description / Table of Contents: Introduction -- Framing the double transition and the international intervention -- The division and destruction of Sarajevo -- The consolidation of the division after the war -- The struggle to rebuild ethnic diversity in Sarajevo -- The incomplete economic transition -- The urban spatial reconfiguration of Sarajevo -- The ethnic reconfiguration in the urban area of Sarajevo -- Conclusions.
    Abstract: Following the signing of the peace agreement and the end of three-and-a-half years of siege, Sarajevo simultaneously experienced a double transition, from war to peace and from socialism to capitalism, that was marked by an increasing international intervention. This book presents a study of the urban transformation of Sarajevo during the post-war period and considers both the role and the impact of the international community in its spatial and ethnic configuration. Part I focuses on the period of maximum international involvement developed at local level, from December 1995 until 2003, and comprises chapters on the ethno-territorial division of the city, the reconstruction of its ethnic diversity and the liberal transition fostered and imposed internationally. Part II deals with the impact of these policies on the current spatial, functional and ethnic configuration in the area of Sarajevo.
    Type of Medium: Online Resource
    Pages: XVII, 136 p. 10 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030805753
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 91
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Sociology, Urban. ; Regional economics. ; Spatial economics. ; Cities and towns History. ; Geography. ; Urban Sociology. ; Regional and Spatial Economics. ; Urban History.
    Description / Table of Contents: Introduction -- The natural city -- Additional theoretical lenses to understand the city -- Historical notes on Tirana -- Tirana patterns at a glance -- Holistic approach to Tirana pattern analysis -- Methodology for holistic understanding of the urban patterns -- Conclusions.
    Abstract: The ideas presented in this book are a conceptual leverage to correct the rigidity of top-down practices and bring the real city, or the city of everyday life, closer to the city of conventional planning. Considering self-organization as the starting point at the base of complex systems, this book tries to understand how specific qualities emerge and evolve from this behavior. For this, the book discusses new ways of looking at and understanding cities by applying holistic methods and approaches based on the conceptual grounds of quantum, fractal, and complexity theories. The book highlights the fact that the information on how to transform and build a city is contained within the city itself. In this regard, some methodological steps to unpack complexities and translate the essential qualities of space into potential generators for city design and planning are provided. The book urges courageous experimentation and proposes a methodology where the computational nature of urban phenomena goes along with historic anthropological ideas, thus emphasizing the characteristics of a specific reality in a model. They do not exclude each other; in fact, they are part of the unbroken web of wholeness. Importantly, the proposed methodology supports gradual and natural coevolution process in the city through combining planned and unplanned actions and the involving multiplicity of actors, impacting on Urban Planning and Design Practice.
    Type of Medium: Online Resource
    Pages: IX, 262 p. 135 illus., 103 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030827311
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 92
    Keywords: Environmental geography. ; Natural disasters. ; Human ecology Study and teaching. ; Architecture History. ; Cultural property. ; Human geography. ; Cultural geography. ; Integrated Geography. ; Natural Hazards. ; Environmental Studies. ; Architectural History and Theory. ; Cultural Heritage. ; Social and Cultural Geography.
    Description / Table of Contents: Introduction -- Part I: Heritage and collective memory for resilience and reconstruction -- Thinking about post-disaster reconstruction in Europe: Functionalist and identity approaches -- Old Souks of Aleppo: A narrative approach to post-conflict heritage reconstruction -- Photography for the city, between the need for protection, conservation and civic identity -- Cultural heritage as stones of memory: The recovery of archives in the area of the Marche crater -- Intangible heritage and resilience in managing disaster shelters: Case study in Japan -- Water gives, water takes away. Memory, agency and resilience in ENSO-vulnerable historic landscapes in Peru -- Intangible cultural economy, a mould for tangible urban built fabric – The case of Shahjahanabad, India -- The Tree: The concept of place after the earthquake, L’Aquila -- Part II: Historic and contemporary reconstructions of historic cities -- Marsica: One hundred years on -- Coventry: Shell or Phoenix, city of tomorrow or concrete jumble? From reconstruction to the Phoenix Initiative, UK -- Post-trauma recovery of monumental buildings in Italy and the United States at the beginning of twentieth century -- Historical town centres and post-seismic reconstructions: Between functional recovery and heritage value awareness -- Integrating green solutions into post-earthquake recovery of Bam, Iran -- Reconstruction of heritage and spirit: Mending the scars of Aleppo -- Beyond the damage, the reconstruction of L’Aguila -- The “Solidere” effect and the localisation of heritage reconstruction in post-war transitions, Libya -- Bell towers under (seismic) attack: Saving a symbol, once it became a menace -- Ancient city of the future: Notes on the reconstruction of Beirut -- Part III: Society, governance and collective resilience -- Bonding between urban fabric and capacity of collective resilience: The case of Talca historic centre, Chile -- Multi-perspective pre-disaster examination as post-disaster managerial thinking ahead for Hoi An in Vietnam -- Play Street: Experimenting tactical urbanism for urban resilience in Iran -- The preservation of rural landscapes for building resilience in small towns: Insights from north Italy -- Antigua Guatemala, from history of disasters to resilient future -- Emergency management for the built heritage post-earthquake: Emilia-Romagna and Lombardy, Italy -- Factors of educational poverty and resilience responses in L’Aquila’s young population -- Dropout, resilience and cultural heritage: A focus of the ACCESS Project in a highly fragile area -- How can teachers promote resilience in schools?- Part IV: Bringing the 21st century into reconstruction -- Cities in transformation: Smarter reconstruction in historic city centres -- Evaluating visitors’ experiences at St Augustine’s Abbey (Canterbury) -- Seismic Microzonation: A preventive measure for the conservation of the built heritage -- The representation of a resilient city: The case of Amatrice’s reconstruction -- Evacuation simulation considering tourists’ attempts to return home: A case of the Kiyomizu-dera Temple area, Japan -- Public administration versus social media in emergency situations -- Social media and disaster management in Iran: Lorestan floods as case study -- Environmental issues and energy potentials in post-earthquake reconstruction -- A multidisciplinary approach to retrofitting historic buildings: The case of the former San Salvatore Hospital, L’Aquila.
    Abstract: This book examines reconstruction and resilience of historic cities and societies from multiple disciplinary and complementary perspectives and, by doing so, it helps researchers and practitioners alike, among them reconstruction managers, urban governance and professionals. The book builds on carefully selected and updated papers accepted for the 2019 Silk Cities international conference on ‘reconstruction, recovery and resilience of historic cities and societies’, the third Silk Cities conference held in L’Aquila, Italy, 10-12 July 2019, working with University of L’Aquila and UCL. This multi-scale, and multidisciplinary book offers cross-sectoral and complimentary voices from multiple stakeholders, including academia, urban governance, NGOs and local populations. It examines post-disaster reconstruction strategies and case studies from Europe, Asia and Latin America that provide a valuable collection for anyone who would like to get a global overview on the subject matter. It thereby enables a deeper understanding of challenges, opportunities and approaches in dealing with historic cities facing disasters at various geographical scales. Additionally, it brings together historical approaches to the reconstruction of historical cities and those of more recent times. Thus, it can be used as a reference book for global understanding of the subject matter.
    Type of Medium: Online Resource
    Pages: XVI, 666 p. 238 illus., 204 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030773564
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 93
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Climatology. ; Environmental health. ; Human geography. ; Environmental management. ; Integrated Geography. ; Climate Sciences. ; Environmental Health. ; Human Geography. ; Environmental Management.
    Description / Table of Contents: I. Introductory -- 1. Introduction: Extreme Weather and Human Health: Global Perspective -- 2. Dust Storms and Human Health -- 3. The Impacts of Climate Change on Health and Development in Canadian Arctic and Sub-Arctic Communities in the 21st Century: A Systematic Review -- 4. Wildland Fire, Extreme Weather, and Society: Implications of a History of Fire Suppression in California, USA -- 5. Extreme Weather Events, Health and Development.
    Abstract: This edited book assesses the impacts of various extreme weather events on human health and development from a global perspective, and includes several case studies in various geographical regions around the globe. Covering all continents, it describes the impact of extreme weather conditions such as flash floods, heatwaves, cold waves, droughts, forest fires, strong winds and storms in both developing and developed countries. The contributing authors also investigate the spread of diseases and the risk to food security caused by drought and flooding. Further, the book discusses the economic damage resulting from natural disasters including hurricanes. It has been estimated that in 2017 natural disasters and climate change resulted in economic losses of 309 billion US dollars. Scientists also predict that if nothing is done to curb the effects of climate change, in Europe the death toll due to weather disasters could rise 50-fold by the end of the 21st century, with extreme heat alone causing more than 150,000 deaths a year, as the report on global warming of 1.5°C warns that China, Russia and Canada’s current climate policies would steer the world above a catastrophic 5°C of warming by the end of 2100. As such, the book highlights how the wellbeing of different populations is threatened by extreme events now and in the foreseeable future.
    Type of Medium: Online Resource
    Pages: XVIII, 382 p. 83 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030237738
    DDC: 910
    Language: English
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  • 94
    Keywords: Pharmacology. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Pharmacology. ; Biomedical Research. ; Medical Genetics.
    Description / Table of Contents: Chapter 1. Introduction and Principles of Pharmacogenomics and Precision medicine -- Chapter 2. Pharmacogenomics in Cardiovascular Diseases -- Chapter 3. Pharmacogenomics of Antitumor Chemotherapeutic Agents -- Chapter 4. Pharmacogenomics of Antitumor Targeted Agent and Immunotherapy -- Chapter 5. Pharmacogenomics of Immunosuppressant -- Chapter 6. Pharmacogenomics of Psychiatric drugs -- Chapter 7. Pharmacogenomics of Anti-Infective Agents -- Chapter 8. Pharmacogenomics of Antithrombotic drugs -- Chapter 9. Pharmacogenomics in Therapeutic Drug Monitoring -- Chapter 10. Pharmacomicrobiomics -- Chapter 11. Genotyping technology in Pharmacogenomics -- Chapter 12. The Ethical, Legal and Regulatory Issues Associated with Pharmacogenomics -- Chapter 13. Cost-effectiveness of pharmacogenetic-guided treatment -- Chapter 14. Application of pharmacogenomics in drug discovery and development -- Chapter 15. Barriers and Solutions in Clinical Implementation of Pharmacogenomics for Personalized Precision Medicine.
    Abstract: This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.
    Type of Medium: Online Resource
    Pages: VIII, 289 p. 33 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811538957
    DDC: 615
    Language: English
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  • 95
    Keywords: Pharmacology. ; Therapeutics. ; Internal medicine. ; Fungi. ; Mycology. ; Microbiology. ; Medical microbiology. ; Pharmacology. ; Therapeutics. ; Internal Medicine. ; Fungi. ; Medical Microbiology.
    Description / Table of Contents: Chapter 1. Mushrooms as Promising Therapeutic Resources: Review and Future Perspectives -- Chapter 2. Medicinal Mushrooms for Respiratory Health -- Chapter 3. Therapeutic and Prophylactic Potential of Medicinal Mushrooms in COVID-19 -- Chapter 4. Influences of Edible Mushrooms on Dynamic and Diversity of Gut Microbiota -- Chapter 5. Mushrooms – From Traditional Remedies to the Modern Therapeutics -- Chapter 6. Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health -- Chapter 7. Anticancer Potential of Ganoderma lucidum and İts Relevant Modes of Action -- Chapter 8. Cognitive Enhancing Effects of Medicinal Mushrooms: A Potential Neuroprotective Implication in Dementias -- Chapter 9. Potential of Medicinal Mushrooms in Human Health and Welfare: An Overview -- Chapter 10. Mycotherapeutics Reduce Nephrotoxicity and Renal Diseases -- Chapter 11. Proteomic Research on the Therapeutic Properties of Medicinal Mushrooms -- Chapter 12. Cordyceps militaris (L.): Medicinal aspects in terms of ethnobotanical and pharmacological perspectives -- Chapter 13. Mycotherapeutics Affecting Dopaminergic Neurotransmission to Exert Neuroprotection -- Chapter 14. Biological Activities of Some Edible Mushrooms -- Chapter 15. Nephroprotective Effects of Four Ganoderma Species -- Chapter 16. Mechanisms Involved in Edible Mushrooms' Health Beneficial Effects -- Chapter 17. Mycotherapy (Medicinal Mushrooms) as a Potential Treatment for Epilepsy -- Chapter 18. Natural vs. Synthetic Psilocybin: The Same or Completely Different? -- Chapter 19. Preventative and Curative Properties of Reishi and Maitake Mushrooms in Cancer.
    Abstract: The book presents new and novel perceptions about ailments alleviating the effects of several mushroom species. Also, the book highlights the curative role of medicinal mushrooms on some peripheral and central diseases. Various chapters in the book (primarily reviews) have been dedicated to providing the therapeutic efficacy of mushrooms against respiratory illnesses, gut microbiota, COVID-19, dementia, epilepsy, mental ailments, cancers, cardiovascular, kidney-related diseases, and other common pathologies. Thus, medicinal mushrooms are current and future consumable healthcare products that usually exhibit nourishing properties and possess prophylactic and therapeutic values with minimal adverse effects and contraindications. The book focuses on Sustainable Development Goal (SDG 3) to promote healthy lives and well-being for all. Medical, pharmacy, nursing, and CAM (complementary and alternative medicine) students, practitioners, scholars, researchers, other healthcare professionals, and general readers are this book’s potential audience. The book can be adopted as a textbook for undergraduate and graduate courses so that the therapeutic potential of mushrooms can reach a wider audience. This book strives to create a new resource for the future use of medicinal mushrooms in various disorders. .
    Type of Medium: Online Resource
    Pages: XX, 509 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811995507
    DDC: 615
    Language: English
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  • 96
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Physiology. ; Cytology. ; Life sciences. ; Pharmacology. ; Physiology. ; Cell Biology. ; Life Sciences.
    Description / Table of Contents: Part I: Physiological Functions of Endo-lysosomal Cation Channels -- NAADP-Mediated Ca2+ Signalling -- NAADP-Dependent TPC Current -- NAADP-Evoked Ca2+ Signaling: The DUOX2–HN1L/JPT2–Ryanodine Receptor 1 Axis -- TPC Functions in the Immune System -- Lysosomal Ion Channels and Lysosome– 1 Organelle Interactions -- TRPML1 and TFEB, an Intimate Affair -- Lysosomal Potassium Channels -- Part II Structure and Composition of TPC and TRPML Channels -- Structure and Function of Plant and Mammalian TPC Channels -- A Structural Overview of TRPML1 and the TRPML Family -- Endo-Lysosomal Two-Pore Channels and Their Protein Partners -- Part III: Tools and Methods to Characterize Endolysosomal Cation Channels -- Electrophysiological Techniques on the Study of Endolysosomal Ion Channels -- The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channels -- Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels -- Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging.
    Abstract: This book covers the molecular structures and the cellular and in vivo function of endosomes and lysosomes, i.e. intracellular vesicles which are involved in many cellular processes such as endocytosis, intracellular trafficking, degradation of material from inside (e.g. autophagy) and outside the cell as well as exocytosis. Membranes of endolysosomal organelles contain an amazing number and diversity of ion channels. These ion channels are the topic of the present book that focusses on describing the structure, the biophysical properties, physiological functions of endolysosomal ion channels at the molecular, cellular and in vivo level. .
    Type of Medium: Online Resource
    Pages: X, 304 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031315237
    Series Statement: Handbook of Experimental Pharmacology, 278
    DDC: 615
    Language: English
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  • 97
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Medical microbiology. ; Dermatology. ; Orthopedic surgery. ; Pharmacology. ; Medical Microbiology. ; Dermatology. ; Surgical Orthopedics.
    Description / Table of Contents: Part 1-Nanotechnology in Skin Infections -- Atopic dermatitis and current trends in pharmacological treatment - a nanoparticulate approach -- Acne vulgaris - recent trends on pharmacological and nanotechnological approaches in therapeutics -- Nitric oxide nanoparticles on skin infections: Current State and Future Prospects -- Metal Nanoparticles Based Antibacterial Nanocomposites for Skin Infections -- Combination therapy using metal nanoparticles for skin infection -- Applications of nanometals in cutaneous infections -- Antifungal nanotherapy: a novel approach to combat superficial fungal infections -- Biocompatible polymers for skin Nanomedicines -- Part 2-Nanotechnology on Soft-Tissue Infections -- Nanotechnological approach to manage diabetic foot ulcer -- Metal nanoparticles in wound infections -- Advances in nanomedicine for burn wound infection treatment -- Applications of chitosan in formulation of novel antibacterial agents and wound dressings -- Polymeric nanocomposites for skin and soft tissues -- Nanoformulations of polyphenols for the treatment of soft tissues infections -- Cutting Edge Nanotechnologies for Targeting Liver Disorders -- NanoCurcumin compounds formulations: Perspectives in skin and soft tissues infections -- Nanobiotechnology strategies for the treatment tegumentary and visceral leishmaniases, and emergence resistance -- Part 3-Nanotechnology in Bone Infections -- Artificial Scaffolds for Bone Tissue Engineering -- The bone biology and the nanotechnology for bone infections and bone engineering -- Part 4-Nanotechnology and Toxicity -- Genotoxicity studies of Silver Nanoparticles in in vivo and in vitro models.
    Abstract: The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft-Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.
    Type of Medium: Online Resource
    Pages: XI, 285 p. 39 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030351472
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Cancer. ; Clinical biochemistry. ; Pharmacology. ; Cancer Biology. ; Medical Biochemistry.
    Description / Table of Contents: Part 1. New Roles for Sphingolipid Signaling and Cell Function -- 1. Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma -- 2. Exploring the Therapeutic Landscape of Sphingomyelinases -- 3. Sphingosine kinases as druggable targets -- Part 2. Phospholipase D and Mitogen Phosphatidic Acid in Human Disease -- 4. Prospects for PLD inhibition in cancer and thrombotic disease -- 5. Phospholipase D and the Mitogen Phosphatidic Acid in Human Disease: Inhibitors of PLD at the Crossroads of Phospholipid Biology and Cancer -- 6. Role of Phospholipase D-Derived Phosphatidic Acid in Regulated Exocytosis and Neurological Disease -- Part 3. Lipid Kinases and Novel Regulatory Pathways -- 7. Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors -- 8. Functions of Nuclear Polyphosphoinositides -- Part 4. Bioactive Lipids in Health and Disease -- 9. Platelet-Activating Factor as an Effector for Environmental Stressors -- 10. Phospholipase D and Choline Metabolism -- Part 5- Lipids and Membrane Microdomains -- 11. Regulation of Inositol Biosynthesis: Balancing Health and Pathophysiology -- 12. Lipids and Membrane Microdomains: The Glycerolipid and Alkylphosphocholine Class of Cancer Chemotherapeutic Drugs -- Part 6. Nuclear Trafficking of Lipids -- 13. Inositide-Dependent Nuclear Signalling in Health and Disease -- 14. Lipids in Exosome Biology.
    Abstract: Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important. .
    Type of Medium: Online Resource
    Pages: XIV, 336 p. 50 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030336684
    Series Statement: Handbook of Experimental Pharmacology, 259
    DDC: 615
    Language: English
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  • 99
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Gynecology . ; Environmental health. ; Pharmacology. ; Gynecology. ; Environmental Health.
    Description / Table of Contents: Preface -- Environmental Exposure Measurements and Evaluations -- Prenatal Smoke Exposure and Child Health -- Prenatal Pesticide Exposure and Child Health -- Prenatal Metal Exposure and Child Health -- Prenatal Stress and Child Health -- The Special Vulnerabilities of Child to Environmental Hazards -- Early-life Environmental Influences on Growth -- Early-life Environmental Influences on Neural Development -- Early-life Environmental Influences on Allergic Diseases -- Early-life Social and Economic Adversities on Health -- Endocrine Disrupting Chemical Exposure and Later-onset Diseases -- Paternal Specific Exposure and Child Health -- Molecular Mechanism of Early-life Chemical Exposure Induced Harmful Effects -- Transgenerational Effects on Developmental Origins of Diseases.
    Abstract: This book offers valuable insights into the latest concepts and findings from epidemiologic, clinical and basic studies in the burgeoning area of early-life environmental exposure and diseases. The book is divided into five parts, starting with an overview of environmental exposure measurement and evaluation, followed by a review of the effects of exposure to various substances like tobacco smoke, pesticides and metals as well as stress on offspring’s health. It then discusses the developmental origins of a range of childhood diseases that affect growth, neural development and the immune system, and highlights the importance of longitudinal studies that measure exposure at potentially sensitive time points during childhood. It also provides up-to-date evidence of the intergenerational/transgenerational effects of early-life environmental exposure, especially via genetic and epigenetic pathways. Allowing readers to gain a thorough understanding of the predominating aspects of early-life environmental exposure and diseases, the book also provides a basis for developing environmental and health policies that could have wide and long-term impacts on human health. .
    Type of Medium: Online Resource
    Pages: XVI, 239 p. 22 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811537974
    DDC: 615
    Language: English
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  • 100
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Clinical biochemistry. ; Medicinal chemistry. ; Pharmacy. ; Pharmacology. ; Medical Biochemistry. ; Medicinal Chemistry. ; Pharmacy.
    Description / Table of Contents: Chapter 1. Coleus forskohlii – A multipurpose medicinal plant -- Chapter 2. Botany of Coleus forskohlii -- Chapter 3. Traditional Medicinal Uses and Pharmacognosy of Coleus forskohlii -- Chapter 4. Chemistry of Coleus forskohlii Briq. -- Chapter 5. Pharmacology of Coleus forskohlii and Forskolin -- Chapter 6. Micropropagation of Coleus forskohlii -- Chapter 7. In Vitro Production of Forskolin -- Chapter 8. Assessment of Coleus forskohlii Genetic Diversity Using Molecular Markers -- Chapter 9. Endophytes for the enhanced growth of Coleus forskohlii and enhanced production of Forskolin -- Chapter 10. Propagation Methods of Coleus forskohlii -- Chapter 11. Success stories and Trade and Commerce of Coleus forskohlii.
    Abstract: This monograph compiles updated information about forskolin, a labdane diterpene that is produced by the Coleus plant. Forskolin has a large number of practical uses and the book delves into the various aspects of this chemical. It includes topics such as the botanical source of forskolin and the cultivation of Coleus forskohlii, source. It also covers the biosynthetic pathways in natural sources and also through different biotechnological applications. Chapters include the potential and products in the Forskolin market. The book also covers the methods for enhanced production of forskolin from natural sources and through tissue culture methods for improvement of the plant for higher content of forskolin. It discusses the role of endophytes in the production of forskolin. The book is useful for students and researchers in the field of botany, pharmacology and biochemistry. It also serves scientists in various pharmaceutical industries.
    Type of Medium: Online Resource
    Pages: XI, 177 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811965210
    DDC: 615
    Language: English
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