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  • Books  (98)
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  • Cham :Springer International Publishing :  (98)
  • Berlin : Akad.-Verl.
  • Bremerhaven : Alfred-Wegener-Inst. für Polar- und Meeresforschung
  • University of Virginia Library
  • Wabern : Federal Office of Topography, Swiss Geological Survey
  • 612.8  (98)
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  • Books  (98)
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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Human physiology. ; Neurology . ; Life sciences. ; Physiology. ; Neuroscience. ; Human Physiology. ; Neurology. ; Life Sciences. ; Animal Physiology. ; Life Sciences.
    Description / Table of Contents: Part I: HISTORY -- Chapter 1: Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek -- Part II: GENERAL ASPECTS OF PRIONS -- Chapter 2: The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein -- Chapter 3: Mammalian Prion Structures -- Chapter 4: Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein Aggregates in the Brain of Asymptomatic Individuals -- Part III: CONVERSION AND STRAIN OF PRIONS -- Chapter 5: Prion Conversion and Deformed Templating -- Chapter 6: Prion Strain Interference -- Chapter 7: Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins -- Chapter 8: Cofactor Involvement in Prion Propagation -- Chapter 9: Prion Protein Conversion and Lipids -- Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS -- Chapter 10: Prions in the Environment -- Chapter 11: Environmentally Acquired Transmissible Spongiform Encephalopathy -- Chapter 12: Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion -- Chapter 13: Species Barriers in Prion Disease -- Part V: MODELLING OF PRIONS -- Chapter 14: Modeling the Cell Biology of Prions -- Chapter 15: Transgenic Mice Modelling in Prion Diseases -- Chapter 16: Stem Cell Models in Prion Research -- Chapter 17: Drosophila Models of Prion Diseases -- Part VI: HUMAN PRION DISEASES AND OTHER PATHOLOGIES -- Chapter 18: Human Sporadic Prion Diseases -- Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases -- Chapter 20: Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies -- Chapter 21: The Spectrum of Tau Pathology in Human Prion Disease -- Chapter 22: Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease -- Chapter 23: Prion and Cancers -- Chapter 24: Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury -- Part VII: ANIMAL PRION DISEASES -- Chapter 25: Bovine Spongiform Encephalopathy -- Chapter 26: Classical and Atypical Scrapie in Sheep and Goats -- Chapter 27: Research models for studying chronic wasting disease -- Part VIII: YEAST PRIONS -- Chapter 28: Introduction to Yeast and Fungal Prions -- Chapter 29: Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems -- Part IX: DIAGNOSIS AND HUMAN PRION SURVEILLANCE -- Chapter 30: Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of human prion diseases -- Chapter 31: Protein Misfolding Cyclic Amplification -- Chapter 32: Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases -- Chapter 33: Diagnosis of Prion Disease: Conventional Approaches -- Chapter 34: Human Prion Disease Surveillance -- Part X: TREATMENT -- Chapter 35: Overview on Treatment of Prion Diseases and Decontamination of Prions -- Chapter 36: Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases -- Chapter 37: Immunomodulation.
    Abstract: Transmissible spongiform encephalopathies (TSE), now known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains the most authoritative views about the past, present, and future of prions and prion diseases covering fresh perspectives on important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
    Type of Medium: Online Resource
    Pages: XII, 793 p. 81 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031205651
    DDC: 612.8
    Language: English
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  • 2
    Keywords: Neurosciences. ; Pain medicine. ; Neurology . ; Anesthesiology. ; Neuroscience. ; Pain Medicine. ; Neurology. ; Anesthesiology.
    Description / Table of Contents: Introduction to Acute, Chronic, and Episodic Pain -- Inflammation and Pain -- Animal Models of Pain and Anti-inflammatory Treatments -- Inflammatory Mediators, Nociceptors, and Their Interactions in Pain -- Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons -- Sex Differences in Neuroimmune Interactions and Pain -- Neuroimmune Interactions in Itch -- Toll-like Receptors in Pain and Itch -- Immunotherapy and Pain -- Cell Therapy and Regenerative Pain Medicine - Preclinical Studies -- Cell-based Therapies in Pain Management -- Platelet-Rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain -- Exercise and Diet in the Control of Inflammation and Pain -- Mechanism-Based Pain Therapies -- Neuromodulation in Pain Management -- What Patients Need to Know about Pain Therapy?.
    Abstract: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
    Type of Medium: Online Resource
    Pages: X, 364 p. 45 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031292316
    DDC: 612.8
    Language: English
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  • 3
    Keywords: Neurosciences. ; Cognitive neuroscience. ; Psychobiology. ; Human behavior. ; Sociology. ; Neuroscience. ; Cognitive Neuroscience. ; Behavioral Neuroscience. ; Sociology.
    Description / Table of Contents: Molecular imaging of the human emotion circuit -- The neurocognitive mechanisms of unconscious emotional responses -- Social and Affective Neuroscience of Embodiment -- The neuroscience of beauty -- Mirror Neurons … in action: ERPs and neuroimaging evidence -- Sex differences in social cognition -- Development of morality and emotional processing -- Trust in Social Interaction: From Dyads to Civilizations -- The time has come to be mindwanderful: Mind wandering and the intuitive psychology mode -- Social Cognition development and socio affective dysfunction in childhood and adolescence -- Clinical neuroscience meets second-person neuropsychiatry -- EEG and ERPs in the study of Language and Social Knowledge -- fMRI and fNIRS methods for social brain studies: hyperscanning possibilities -- Modulating the Social and Affective Brain with transcranial stimulation techniques -- What our eyes can tell us about our social and affective brain? -- Facial EMG – Investigating the interplay of facial muscles and emotions.
    Abstract: This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers.
    Type of Medium: Online Resource
    Pages: XXXIII, 302 p. 55 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031086519
    DDC: 612.8
    Language: English
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  • 4
    Keywords: Neurosciences. ; Neurology . ; Pharmacology. ; Neuroscience. ; Neurology. ; Pharmacology.
    Description / Table of Contents: Chapter 1: Why study Drug Resistant Epilepsy? -- Chapter 2: Pharmacoresistance in Epilepsy -- Chapter 3: Experimental models for the study of drug-resistant epilepsy -- Chapter 4: On Complexity and Emergence: Linking the Hypotheses of Pharmacoresistance in Epilepsy -- Chapter 5: Role of High-Frequency Oscillation Networks in Managing Pharmacoresistant Epilepsy -- Chapter 6: Transporter hypothesis in pharmacoresistant epilepsies. Is it at the central or peripheral level? -- Chapter 7: Changes in Targets as an Explanation for Drug Resistance in Epilepsy -- Chapter 8: Cellular and molecular mechanisms of neuroinflammation in drug-resistant epilepsy -- Chapter 9: Contribution of the antiepileptic drug administration regime to avoid the development and/or establishment of pharmacoresistant epilepsy -- Chapter 10: Pharmacogenetics in Epilepsy and Refractory Epilepsy -- Chapter 11: Seizures Induce Hypoxia or Hypoxia Induces Seizures. A Perverse Relationship that Increases the Risk of SUDEP -- Chapter 12: Neonatal excitotoxicity triggers degenerative processes related to seizure susceptibility and pharmacoresistance -- Chapter 13: Cerebrovascular remodeling and the role of vascular endothelial growth factor in the epileptic brain and pharmacoresistance -- Chapter 14: The Role of JNK3 in Epilepsy and Neurodegeneration -- Chapter 15: Application of proteomics in the study of molecular markers in epilepsy -- Chapter 16: GABAergic neurotransmission abnormalities in pharmacoresistant epilepsy: experimental and human studies -- Chapter 17: Genes involved in pharmacoresistant epilepsy -- Chapter 18: Drug-resistant Epilepsy and the Influence of Age, Gender and Comorbid Disorders -- Chapter 19: Indications for Intracerebral Recording in Candidates for Epilepsy Surgery -- Chapter 20: On the Development of New Drugs for the Treatment of Drug Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses -- Chapter 21: Physical exercise as a strategy to reduce seizure susceptibility -- Chapter 22: Ketogenic Diet and Drug-resistant Epilepsy -- Chapter 23: Modulating P-glycoprotein Regulation as a Therapeutic Strategy for Pharmacoresistant Epilepsy -- Chapter 24: Vagus Nerve Stimulation for Intractable Seizures -- Chapter 25: Non Invasive Brain Stimulation as a potential Therapeutic Procedure in drug-resistant epilepsy -- Chapter 26: Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity.
    Abstract: This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.
    Type of Medium: Online Resource
    Pages: XV, 596 p. 84 illus., 79 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031365263
    DDC: 612.8
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurology . ; Developmental neurobiology. ; Neuroscience. ; Neurology. ; Development of the Nervous System.
    Description / Table of Contents: The development of the cerebellum: from the beginnings -- Part I: Responsibilities and liabilities -- Chapter2. The embryology and anatomy of the cerebellum -- Chapter 3. Cellular and genetic programs underlying cerebellum development -- Chapter 4. Early Purkinje Cell Development and the Origins of Cerebellar Patterning. - Chapter 5. Development of the Fish Cerebellum. -Chapter 6. Cerebellar developmental disorders and cerebellar nuclei -- Chapter 7. Motor circuit abnormalities during cerebellar development -- Chapter8. Developmental disorders of the cerebellum and neurotrophic factors -- Chapter9. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development -- Chapter10. The ubiquitin proteasome system and cerebellar developmental disease -- Chapter11. Epigenetics and Cerebellar Neurodevelopmental Disorders -- Chapter12.. Hormonal regulation of cerebellar development and its disorders -- Chapter13. Infections of the Cerebellum -- Chapter14. Neuroimmune mechanisms of cerebellar development and its developmental disorders -- Chapter15. Teratogenic influences on cerebellar development -- Chapter16. Primary pediatric brain tumors of the posterior fossa -- Chapter17. Primary pediatric brain tumors of the posterior fossa -- Chapter18. Can cerebellar neurodevelopmental disorders affect behavioral disorders or vice versa -- Chapter19. Neurodevelopmental disorders of the cerebellum: autism spectrum disorder -- Chapter20. Congenital cerebellar disease -- Chapter21. Clinical features, assessment, and management of patients with developmental and other cerebellar disorders -- Chapter22. Epidemiology of cerebellar disorders -- Chapter23. Cerebellar transplantation: a potential model to study repair and development of neurons and circuits in the cerebellum. - Chapter 24. Non-coding RNAs and cerebellar development. - Chapter 25. Defining the Cerebellar Cytoarchitecture Using MRI. .
    Abstract: This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.
    Type of Medium: Online Resource
    Pages: IX, 639 p. 116 illus., 88 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031231049
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurophysiology. ; Gastroenterology. ; Neuroscience. ; Neurophysiology. ; Gastroenterology.
    Description / Table of Contents: Tools for optogenetic probing of nociceptive pathways; Monitoring activity -- An open science model to accelerate the generation, implementation and distribution of optogenetics and viral tools -- Vagal neuroinflammation accompanying respiratory viral infection: An overview of mechanisms and possible clinical significance -- Stress-induced Visceral Analgesia: Concept and Pathways -- Evidence of early life stress exposure and epigenetic modifications in functional chronic pain disorders -- EPIGENETIC REGULATION OF STRESS-INDUCED VISCERAL PAIN -- The biomechanics and mechanotransduction in visceral nociception -- VISCERAL NOCICEPTION IN GASTROINTESTINAL DISEASE -- Epithelial-Neuronal Communication in Visceral Pain -- Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome -- A fentanyl analogue that activates u-opioid receptors in acidified tissues inhibits colitis pain without opioid side effects -- Signalling in the Gut -- Translating colonic sensory afferent peripheral mechanosensitivity into the spinal cord dorsal horn -- Translating colonic afferent peripheral sensitivity into the spinal cord dorsal horn -- Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain -- Pre-clinical Models of Endometriosis -- Spinal afferent innervation of the uterus -- Post-infectious bladder hypersensitivity in the development of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).
    Abstract: The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.
    Type of Medium: Online Resource
    Pages: VIII, 255 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031257025
    DDC: 612.8
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Neuropsychology. ; Psychiatry.
    Description / Table of Contents: Part 1: Considering sex and gender in research studies -- Sex and Gender Science -- Best practices in the study of sex? -- Best practices in the study of Gender Differences -- The special case of a lack of sex differences – the naked mole rat? -- Lateralization and -- Part 2: Sex differences in cognitive and mental health across the lifespan -- Depression -- Schizophrenia -- Immune and neurodevelopmental disorders – autism? -- Social Cognition -- Cognition and cognitive ageing -- Part 3: Diseases of the brain and relevance of sex -- Epilepsy -- Stroke -- AD -- Parkinson’s -- Multiple Sclerosis.
    Abstract: Does sex matter when it comes to brain function? This volume attempts to answer this very important question which is of relevance to the disciplines of psychology, neuroscience, psychiatry and neurology. Understanding how brain function and resultant behaviors may differ between the sexes impacts upon our knowledge of the pathology and development of treatments for various neurological and psychiatric disorders, particularly those that show significant sex differences in either prevalence and/or manifestation of symptoms. This volume covers three main themes of research into sex differences in basic neurobiology, psychology, preclinical research and clinical research. It begins by exploring our understanding of sex and gender in relation to both animal and human behaviors and discusses the relevance, and importance, of considering sex and gender when conducting research into brain function and behaviors. The second theme focuses on how sex and gender influence mental health and considers the impact of our immune system and the changes that occur with ageing. Finally, the third aspect focuses on examples of neurological disorder which show sex differences in terms of their aetiology and/or symptomology and considers the relevance in the development of treatment for these disorders including dementia, stroke and multiple sclerosis. This volume is of considerable interest to mental health and neurology professionals, including psychiatrists, neurologists, nurses, allied health clinicians and pharmacists. It is also helpful and important for preclinical researchers working in neuroscience, psychopharmacology and reproductive endocrinology.
    Type of Medium: Online Resource
    Pages: X, 373 p. 70 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031267239
    Series Statement: Current Topics in Behavioral Neurosciences, 62
    DDC: 612.8
    Language: English
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  • 8
    Keywords: Neurosciences. ; Neurology . ; Pharmaceutical chemistry. ; Cognitive neuroscience. ; Neuroscience. ; Neurology. ; Pharmaceutics. ; Cognitive Neuroscience.
    Description / Table of Contents: Part I: Basic Science of Cerebellum and Ataxias -- Functional anatomy of the cerebellum -- Cerebellar physiology -- Cerebellar biochemistry/pharmacology -- Genetics of dominant ataxias -- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics -- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches -- Ion Channel Genes and Ataxia -- Part II: Biomarkers and tools of trials -- How to Design a Therapeutic Trial in SCAs -- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers -- Clinical rating scales for ataxia -- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding -- Cerebellar learning in the prism adaptation task -- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias -- Part III: Autosomal Dominant Cerebellar Ataxias -- Riluzole in progressive cerebellar ataxias -- ASOs against ATXN2 in preclinical and phase 1 trials -- Antisense oligonucleotide therapy against SCA3 -- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities -- Experimental neurotransplantation for cerebellar ataxias -- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside -- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia -- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias -- Physical therapy in Cerebellar Ataxia -- Part IV: Autosomal Recessive Cerebellar Ataxias -- Recent advances on therapeutic approaches for Friedreich’s Ataxia -- Therapeutic use of interferon gamma in Friedreich ataxia -- Metabolic treatments of cerebellar ataxia -- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome -- Part V: Sporadic Ataxias -- Therapeutic strategies in immune-mediated cerebellar ataxias -- Coenzyme Q10 in MSA -- State of the Art and History of Therapeutics in Ataxias.
    Abstract: Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
    Type of Medium: Online Resource
    Pages: XI, 727 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031243455
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: Chapter 1: Understanding the Mechanisms of Dendritic Arbor Development: Integrated Experimental and Computational Approaches -- Chapter 2: Autophagy Mechanisms for Brain Recovery. Keep It Clean, Keep It Alive -- Chapter 3: Environmental enrichment and functional plasticity in the hippocampus, an update on the mechanisms involved -- Chapter 4: Translatable Models of Brain and Cognitive Reserve -- Chapter 5: Cognitive Reserve: A Life-Course Perspective -- Chapter 6: Neural Correlates of Brain Reserve: A Neuroimaging Perspective -- Chapter 7: Non-pharmacological Approaches Based on Mind-Body Medicine to Enhancement of Cognitive and Brain Reserve in Humans -- Chapter 8: Roles of Synaptic Plasticity in Functional Recovery After Brain Injury -- Chapter 9: Integrated Methods of Neuromodulation for Guiding Recovery Following Stroke -- Chapter 10: Resilience in Brain Networks After Stroke -- Chapter 11: Epigenetics and brain plasticity: back to function -- Chapter 12: Functional Role of Physical Exercise and Omega-3 Fatty Acids on Depression and Mood Disorders -- Chapter 13: BRAIN RECOVERY IN CHILDHOOD: THE INTERACTION BETWEEN DEVELOPMENTAL PLASTICITY AND REGENERATIVE MECHANISMS -- Chapter 14: Estrogen Neuroprotective Activity After Stroke and Spinal Cord Injury -- Chapter 15: Making Meaning of Acquired Brain Injury: Resources for Functional Recovery -- Chapter 16: An Update on Premorbid Personality Traits and Brain Recovery - Another Aspect of Resilience -- Chapter 17: Psychological Aspects of Recovery After Brain Injury: A Focus on Psychodynamic Factors -- Chapter 18: Artificial Intelligence applications for Traumatic Brain Injury research and clinical management.
    Abstract: The importance of this unique book's approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery following injury. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and psychological resilience the authors present a book that will help lead to the development of better treatment strategies for functional recovery from brain damage. The new edition is fully updated throughout and contains completely new chapters on brain recovery in childhood, epigenetic aspects of brain recovery, and artificial intelligence techniques in traumatic brain injury research.
    Type of Medium: Online Resource
    Pages: XXIV, 406 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031249303
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Zoology. ; Neurochemistry. ; Neuroscience. ; Zoology. ; Neurochemistry.
    Description / Table of Contents: 1. Introduction to the complexity of cell surface and tissue matrix glycoconjugates. -- 2. Introduction to cells comprising the nervous system. -- 3. Synthesis -- processing -- and function of N-glycans in N-glycoproteins. -- 4. Synthesis of O-linked glycoconjugates in the nervous system. -- 5. Chemistry and function of glycosaminoglycans in the nervous system. -- 6. Use of glycan-targeted antibodies/lectins to study the expression/function of glycosyltransferases in the nervous system. -- 7. Capillary electrophoresis and mass spectrometry-based glycosylation analysis in glycomics and glycoproteomics. -- 8. Structural analysis of oligosaccharides and glycoconjugates using NMR. -- 9. Glycolipid and glycoprotein expression during neural development. -- 10. Gangliosides and cell surface ganglioside glycohydrolases in the nervous system (request them to include gal-cer and sulfatide). -- 11. Role of myelin-associated glycoproteins in the peripheral nervous system. -- 12. Glycosignaling: a general review. -- 13. Glycosphingolipids in the regulation of the nervous system. -- 14. O-GlcNAcylation of neuronal proteins: Roles in neuronal functions and in neurodegeneration. -- 15. Glycoconjugates in nuclear membranes. -- 16. N-glycosylation in regulation of the nervous system. -- 17. Role of carbohydrates in the interaction of pathogens with neural cells. -- 18. Glycoconjugate changes in aging and age-related diseases. -- 19. Gangliosides and glycolipids in neurodegenerative disorders. -- 20. Inborn errors of glycosphingolipid catabolism and potential treatment. -- 21. Neurological aspects of human glycosylation disorders. -- 22. Glycoconjugates and neural tumors. -- 23. Galectins and neuroinflammation . -- 24. Glycoconjugates and neuroimmunological diseases. -- 25. Targeting nanoparticle drug carriers to the brain. -- 26. Use of quantum dots to treat inherited lysosomal storage diseases. -- 27. MALDI-FTICR MS imaging of nervous system glycoconjugates.
    Abstract: This new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators.
    Type of Medium: Online Resource
    Pages: XII, 501 p. 96 illus., 73 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031123900
    Series Statement: Advances in Neurobiology, 29
    DDC: 612.8
    Language: English
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  • 11
    Keywords: Neurosciences. ; Neurophysiology. ; Developmental neurobiology. ; Neuroscience. ; Neurophysiology. ; Development of the Nervous System.
    Description / Table of Contents: Chapter 1: Introduction: What are dendritic spines? -- Chapter 2: Techniques to render dendritic spines visible in the microscope -- Chapter 3: Electrophysiology of dendritic spines: information processing, dynamic compartmentalization and synaptic plasticity -- Chapter 4: Dendritic spines, synaptogenesis and synaptic pruning for the developmental organization of brain circuits -- Chapter 5: Neurotrophic factors and dendritic spines -- Chapter 6: Glial cell modulation of dendritic spine structure and synaptic function -- Chapter 7: Dendritic spines in learning and memory: from first discoveries to current insights -- Chapter 8: Steroid hormone interaction with dendritic spines: implications for neuropsychiatric disease -- Chapter 9: Morphological features of human dendritic spines.
    Abstract: This reference provides detailed coverage of dendritic spines, the fascinating neuronal components that modulate synaptic transmission, development, strength, and plasticity and are involved in the function of multiple areas of the nervous system. The density, shape, and function of spines may indicate the cellular connectivity and synaptic plasticity in normal and pathological conditions. This field has undergone dramatic advances in terms of techniques and experimental findings from in vitro to in vivo data, from animal models to human neurons, and computational models using artificial intelligence. To address these cutting-edge findings, the book provides state-of-the-art, comprehensive coverage with chapters written by the leading international researchers in the field. The authors consider the multiple implications for the study of dendritic spines with broad implications in the neurosciences and related areas.
    Type of Medium: Online Resource
    Pages: XV, 499 p. 123 illus., 103 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031361593
    Series Statement: Advances in Neurobiology, 34
    DDC: 612.8
    Language: English
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  • 12
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuropsychology. ; Clinical psychology. ; Psychiatry. ; Neuroscience. ; Neuropsychology. ; Clinical Psychology. ; Psychiatry.
    Description / Table of Contents: Preface -- PART 1: To fear or not -- Disambiguating fear as an emotional state vs. threat detection. Molecular and Neural circuits of fear extinction. Psychological and theoretical elements on the concept of fear extinction. Neural circuit of fear extinction: psychophysiology -- PART 2: Individual differences in fear extinction -- The impact of sex differences and sex hormones on fear extinction. Impact of sleep on fear extinction. Impact of stress and exercise on fear extinction. Intersect between the intrinsic and extrinsic factors that modulate fear extinction -- PART 3: Psychopathology -- Fear extinction and its relevance to psychopathology. Developmental fear and its extinction imaging. Fear extinction and adult psychopathology -- Part 4: Therapeutics and neuromodulations of fear extinction -- Exposure therapy and other behavioral therapeutics targeting fear extinction circuits. Novel pharmacotherapeutics targeting fear extinction circuits. Reconsolidation and its link and impact on fear extinction. Technological advances in exposure therapy: virtual and augmented reality. Novel approaches using neurostimulation targeting fear extinction.
    Abstract: This book aims to provide the reader a neuroscientific understanding surrounding a very simple question: how do we learn not to fear? Exploring answers to this question is very important for two reasons. First, learning about the neural mechanisms of fear extinction is of relevance to everyone’s life - it is such a basic yet relevant question to our daily experiences. Therefore, understanding brain mechanisms of fear and its regulation is essential from a basic neuroscience point of view. Second, excessive fear and the inability to regulate its expression is one of the hallmarks of fear-, anxiety-, trauma-, and stressor-related psychopathologies. And as such, learning about how fear is acquired, stored, expressed, and regulated could help advance our understanding of the etiology of psychopathology, the maintenance of symptoms pertaining to failure to regulate fear, and could help us develop novel therapeutics to equip providers and patients with the tools to better quell their fears. The contributions contained in this book are provided by experts in the fields of basic and clinical neuroscience, experimental and clinical psychology, and neuropsychiatry. The contributions are organized to start the reader with basic definitions of how we define fear, how we study its neural circuits at the molecular and cellular levels, how to study human behavior and the brain using state-of-the art experimental and statistical tools, to how much fear contributes to psychopathology. This volume ends with current advances aimed to enhance the capacity to extinguish fear; a clinical result that would aid in the treatment of multiple psychiatric disorders, followed by a discussion on future directions of this highly important and relevant field.
    Type of Medium: Online Resource
    Pages: VIII, 387 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031430053
    Series Statement: Current Topics in Behavioral Neurosciences, 64
    DDC: 612.8
    Language: English
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  • 13
    Keywords: Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Description / Table of Contents: Sensory Regeneration in the Inner Ear: History, Strategies and Prospects -- Non-mammalian Hair Cell Regeneration: Cellular Mechanisms of Morphological and Functional Recovery -- Cell Junctions and the Mechanics of Hair Cell Regeneration -- Mammalian Hair Cell Regeneration -- Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors -- Inner Ear Cells from Stem Cells – a Path Towards Inner Ear Cell Regeneration -- Spiral ganglion neuron regeneration in the cochlea: regeneration of synapses, axons and cells -- Genetic and Epigenetic Strategies for Promoting Hair Cell Regeneration in the Mature Mammalian Inner Ear.
    Abstract: This volume provides a detailed update on progress in the field of hair cell regeneration with emphasis on more "prospective" views of the various facets of regeneration research. Sensory Regeneration in the Inner Ear: History, Strategies and Prospects Mark E. Warchol, and Jennifer S. Stone Non-mammalian Hair Cell Regeneration: Cellular Mechanisms of Morphological and Functional Recovery Madeleine Hewitt, David W. Raible, and Jennifer S. Stone Cell Junctions and the Mechanics of Hair Cell Regeneration Mark A. Rudolf, and Jeffrey T. Corwin Mammalian Hair Cell Regeneration Ruth Taylor, and Andrew Forge Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors Melissa M. McGovern, and Andrew K. Groves Inner Ear Cells from Stem Cells – a Path Towards Inner Ear Cell Regeneration Amanda Janesick, Eri Hashino, and Stefan Heller Spiral ganglion neuron regeneration in the cochlea: regeneration of synapses, axons and cells Steven H. Green, Sepand Bafti, Benjamin M. Gansemer, A. Eliot Shearer, Muhammad Taifur Rahman, Mark E. Warchol, and Marlan R. Hansen Genetic and Epigenetic Strategies for Promoting Hair Cell Regeneration in the Mature Mammalian Inner Ear Brandon C. Cox, John V. Brigande, and Bradley J. WaltersDr. Mark Warchol is Professor of Otolaryngology at Washington University School of Medicine in St. Louis. Dr. Jennifer Stone is Research Professor of Otolgaryngolldy/Head and Neck Surgery, University of Washington School of Medicine, Seattle. Dr. Allison Coffin is an Associate Professor in the Department of Integrative Physiology and Neuroscience at Washington State University Vancouver. Dr. Arthur N. Popper is Professor Emeritus and research professor in the Department of Biology at the University of Maryland, College Park. Dr. Richard R. Fay (Deceased) was Distinguished Research Professor of Psychology at Loyola University Chicago.
    Type of Medium: Online Resource
    Pages: XVI, 229 p. 44 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031206610
    Series Statement: Springer Handbook of Auditory Research, 75
    DDC: 612.8
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Zoology. ; Life sciences. ; Behavior genetics. ; Neuroscience. ; Zoology. ; Life Sciences. ; Behavioral Genetics.
    Description / Table of Contents: Chapter 1. Introduction to neurogenetics -- Chapter 2. Neurogenetic analysis in Caenorhabditis elegans -- Chapter 3. Regionalisation of the early nervous system -- Chapter 4. Early neurogenesis and gliogenesis in Drosophila -- Chapter 5. Neural stem cells and brain tumour models in Drosophila -- Chapter 6. Eye development in Drosophila: from photoreceptor specification to terminal differentiation -- Chapter 7. Neurogenetics of memory, learning and forgetting -- Chapter 8. Evolution and origins of nervous systems -- Chapter 9. Neural stem and progenitor cells in the mammalian brain -- Chapter 10. Models of neurodegenerative diseases.
    Abstract: This textbook provides students with knowledge of neurogenetics, neurogenesis, neuronal specification and function, neuronal networks, learning and memory formation, brain evolution, and neurodegenerative diseases. Students are introduced to topics of classical developmental genetics as well as modern molecular and neurogenetic methods. Using a wealth of examples from current research, the textbook takes a strong applied approach. Using animal models such as Drosophila melanogaster and Caenorhabditis elegans as well as mammalian systems, the interrelationships between genes, neurons, nervous systems, and behaviour under normal and pathological conditions are illustrated. The textbook aims encourage students to address biological questions in neurogenetics and to think about the design of their own experiments. It targets primarily master and graduate students in neurobiology, but is also a valuable teaching tool for instructors in these fields.
    Type of Medium: Online Resource
    Pages: VII, 212 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031077937
    Series Statement: Learning Materials in Biosciences,
    DDC: 612.8
    Language: English
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  • 15
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Endocrine glands. ; Immunology. ; Neuroscience. ; Endocrine System. ; Immunology.
    Description / Table of Contents: Part I. Concepts -- Chapter 1. A History of Immune and Neuroendocrine System Interactions -- Chapter 2. Philosophical Perspectives on Neuroendocrine-Immune Interactions: The Building Block Model and Complementary Neuro-Endocrine-Immune-Microbiota Systems Approaches -- Chapter 3. The Behavioural Immune System of Lower Vertebrates -- Part II. Regulatory Pathways -- Chapter 4. Cytokines and Hypothalamo-Pituitary-Adrenal Axis Activation: Now a Classic of Immune-Neuroendocrine System Interactions -- Chapter 5. Catecholamines and Immunomodulation -- Chapter 6. Neuroendocrine-immune Interactions in Major Depressive Disorder: Glucocorticoids and Glucocorticoid Receptors -- Chapter 7. Brain Fluids, Blood-Brain Interfaces, and Their Involvement in Neuroimmune Regulation During Development and in Adulthood -- Chapter 8. Neuropeptide Binding Autoantibodies Regulating Neuroendocrine Communications -- Part III. Modulation -- Chapter 9. Postnatal Development of Neuroimmune Responses -- Chapter 10. Sex Differences in Neuroendocrine-Immune Interactions -- Chapter 11. Biological Clocks and Immune Function -- Chapter 12. Influence of the Gut Microbiota on Neuroendocrine-Immune Interactions -- Part IV. Disease -- Chapter 13. Energy Balance and Neuroendocrine-Immune Regulation in Chronic Inflammatory and Neoplastic Diseases: An Evolutionary Perspective -- Chapter 14. Autonomic, Immune, Metabolic and Neuroendocrine Dimensions of Anorexia Nervosa: An Integrative View.
    Abstract: The concepts of the neuroendocrine system and the immune system emerged more or less simultaneously in the second half of the 20th century. Although these systems have a high degree of autonomy, it has also become clear that they interact in many ways and at different levels. This book focuses on the neuroendocrine and immune interactions that are fundamental to normal development and maintenance of health. The first introductory chapters are devoted to the historical and philosophical concepts within the field, as well as evolutionary considerations, offering critical interdisciplinary perspectives on the development of this field of research. Without attempting an exhaustive overview, the book then introduces some of the regulatory pathways that mediate interactions between the neuroendocrine and immune systems and examines modulating factors such as age and sex. In addition, several chapters address the importance of neuroendocrine-immune interactions in some disease states. Readers can expect to gain a broad perspective of neuroendocrine-immune interactions in development, health, and disease, along with a critical evaluation of current methods used in the field. Given its scope, the book is essential reading for undergraduate and graduate students with an interest in neuroendocrinology, neuroimmunology, and neuroscience, as well as postdoctoral fellows and established researchers seeking a comprehensive overview and historical perspective of the field of neuroendocrine-immune interactions.
    Type of Medium: Online Resource
    Pages: XIII, 386 p. 29 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031213588
    Series Statement: Masterclass in Neuroendocrinology, 13
    DDC: 612.8
    Language: English
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  • 16
    Keywords: Neurosciences. ; Neuroanatomy. ; Neurophysiology. ; Developmental neurobiology. ; Cognitive neuroscience. ; Neuroscience. ; Neuroanatomy. ; Neurophysiology. ; Development of the Nervous System. ; Cognitive Neuroscience.
    Abstract: This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.
    Type of Medium: Online Resource
    Pages: XIV, 742 p. 182 illus., 127 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031150708
    DDC: 612.8
    Language: English
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  • 17
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Psychiatry. ; Neurology . ; Neuroscience. ; Psychiatry. ; Neurology.
    Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.
    Abstract: The Dictionary of Hallucinations, second edition, is an alphabetical listing of issues pertaining to hallucinations and other misperceptions. They can be roughly divided into four categories: 1. Definitions of individual hallucinatory symptoms 2. Medical conditions and substances associated with the mediation of hallucinations 3. Historical figures who are known to have experienced hallucinations 4. Miscellaneous issues Each of the definitions of individual hallucinatory symptoms includes: a definition of the term its etymological origin the year of introduction (if known) a reference to the author or authors who introduced the term (if known) a description of the current use a brief explanation of the etiology and pathophysiology of the symptom at hand (if known) references to related terms references to the literature The second edition of A Dictionary of Hallucinations serves as a reference manual for neuroscientists, psychiatrists, psychiatric residents, psychologists, neurologists, historians of psychiatry, general practitioners, and academics dealing professionally with concepts of hallucinations and other sensory deceptions. This new edition provides updated information and references, and includes newly discovered hallucinations, bringing together contributions by other authorities within the field, with all the entries edited by Prof. Blom.
    Type of Medium: Online Resource
    Pages: XXVI, 790 p. 604 illus., 364 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031252488
    DDC: 612.8
    Language: English
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  • 18
    Keywords: Neurosciences. ; Neurology . ; Neurophysiology. ; Neuropharmacology. ; Neuroscience. ; Neurology. ; Neurophysiology. ; Neuropharmacology.
    Description / Table of Contents: Molecular Biomarkers.Somatic instability/Telomeres,- Genetic modifiers -- Current clinical trial biomarkers.-Pharmacodynamic biomarkers for Htt-lowering therapeutics.-Inflammatory biomarkers.-Sleep dysregulation markers.-Mitochondrial/Oxidative stress biomarkers.-Microbiomics -- Metabolomics.-Proteomics.-Transcriptomics.-Lipidomics.-Imaging marker overview.-Retinal imaging biomarkers -- MRI - non-invasive functional MRI measures -- The evolution of clinical trial methodology.-Digital biomarkers -- The future of telehealth -- Summary and future trends.
    Abstract: Huntington’s disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.
    Type of Medium: Online Resource
    Pages: XVI, 475 p. 42 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031328152
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 19
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Regenerative medicine. ; Stem cells. ; Neuroscience. ; Regenerative Medicine and Tissue Engineering. ; Stem Cell Biology.
    Description / Table of Contents: Part 1 General considerations -- Human iPS for clinical applications and cellular products -- 3D-printed iPS disease models -- Part 2 CNS iPSC and organoids -- iPS-derived neurons and brain organoids from patients (brain) -- iPS-derived RGCs (eye) -- iPS-derived glia (brain) -- iPSC to model blood-brain barrier endothelial cells -- Part 3 iPSC-derived nociceptive neurons -- IPSC-based peripheral nerve modeling -- Part 4 Non-neuronal specialized cell types -- iPSC-based drug screening of differentiated cardiomyocyte subtypes -- iPSC-based cardiac disease modeling: from cell to tissue -- iPSC-derived corneal endothelial cell -- iPSC-derived trabecular meshwork (eye) -- iPSC for in vitro disease modeling of diabetes.
    Abstract: Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
    Type of Medium: Online Resource
    Pages: VIII, 332 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031423499
    Series Statement: Handbook of Experimental Pharmacology, 281
    DDC: 612.8
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medical genetics. ; Bioinformatics. ; Neuroscience. ; Medical Genetics. ; Bioinformatics. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Attitudes and smoking prevalence among undergraduate students in central Greece -- 2-Care of patients with Alzheimer’s disease -- 3-Regulation of antioxidant enzymes levels in rat brain -- 4-NIRS-based assessment of cerebral oxygenation during high definition anodal transcranial direct current stimulation in patients with posttraumatic encephalopathy -- 5-Cerebral critical closing pressure at concomitant traumatic brain injury -- 6-The role of inflammatory biomarkers as a diagnostic tool for possible late-life cognitive decline and dementias -- 7-The Development of Antisense RNA Treatments using Engineered Protein Substrates -- 8-Biomarker-driven analysis using high-throughput approaches in neuroinflammation and neurodegenerative diseases -- 9-Sensitive and Stereo specific high-performance liquid chromatographic method for flurbiprofen in human plasma -- 10-Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study -- 11-Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological Voices in Parkinsonian Patients -- 12-Effects of an 8-Week Stress Management Program in Women with Breast Cancer: A Randomized Controlled Trial -- 13-The Rosenberg Self-Esteem Scale: Translation and Validation in the Greek Language in Adolescents -- 14-Stress system activation analysis in Greek female adolescents: a bioimpedance study -- 15-Kisspeptin and the genetic obesity interactome -- 16-The importance of diagnostic and prognostic biomarkers identification and classification towards understanding ALS pathogenesis -- 17-Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia -- 18-Ebola virus disease and current therapeutic strategies; A review -- 19-Hyperbaric Oxygen Therapy effect on “Kinesia Paradoxa” Brain Circuits -- 20-Early and Very Early GRIM19 and MCL1 Expression are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line -- 21-Phospholipid Fatty Acid Profile of Spirulina platensis -- 22-Chronic systemic inflammation measured by bioimpedance technology before and after sleeve gastrectomy: a feasibility study -- 23-Synthesis and Biological Evaluation Substituted Thiophene Derivatives -- 24-Force spectroscopy in mechanical protein domains unfolding -- 25-Investigating the genetic component of Parkinson’s Disease -- 26-Urticaria from the Neurodermatological Perspective: A Temporal Analysis of Urticaria and Cognition -- 27-Novel Low-Noise CMOS Bioamplifier for the Characterization of Neurodegenerative Diseases -- 28-The Kentucky Inventory of Mindfulness Skills in Greek Undergraduate and Postgraduate Students -- 29-Synthesis, in silico stuiesand biological evaluation of 1, 3 ,4 oxadiazino indole derivatives -- 30-Designing and screening of new schiff bases of indole derivatives for anti-bacterial activity by in-silico methods and docking studies -- 31-Use of vitamin D bolus in fortified juice for improving vitamin D status in children with Cerebral Palsy -- 32-Microbes and the games they play -- 33-Impurity Profiling and Identification of 2,6 diisopropylphenol by Raman spectroscopy -- 34-Cultural Accommodation of the Strengthening Families Program for Parents and Young Adolescents 10-14: Greek Phase I & II Study -- 35-The effect of nutrients on Alzheimer’s disease biomarkers: A metabolomic approach -- 36-The impact of exercising in the quality of life of people with Aementia-Alzheimer disease -- 37-Advanced Health Technologies and Nanotechnologies in Neurodegenerative Diseases -- 38-Phenotype and genotype study in a case of frontometaphyseal dysplasia 1 -- 39-Craniofacial and neurological phenotype in a case of oculodentodigital syndrome -- 40-Clinical and molecular study of common thrombophilia mutation prothrombin G20210A -- 41-Prenatal genetic testing for X-linked hypohidrotic ectodermal dysplasia -- 42-Preimplantation genetic testing for spastic paraplegia type 3 -- 43-Synthesis, anti-inflammatory activity and in-silico studies of some new 3-({P-DIMETHYLAMINO}BENZYLIDENE YDRAZINYLIDENE)-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES -- 44-Design, characterization and docking studies of some novel isatin derivatives for anticonvulsant and antidepressant activity -- 45-Skin mirrors Brain: A Chance for Alzheimer’s Disease Research -- 46-Mitochondrial homeostasis in neurodegeneration and ageing -- 47-The Alzheimer's Disease Chronicles: will evidence triumph over adversity? -- 48-Liposomes: Production Methods and Application in Alzheimer’s Disease -- 49-Developing Treatments for Alzheimer’s and Related Disorders with Precision Medicine: A Vision -- 50-Biomarkers and Precision Medicine in Alzheimer’s Disease -- 51-The role of microRNAs in thrombosis -- 52-Photo-oxygenation: an innovative new therapeutic approach against amyloidoses.
    Abstract: The 5th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Neuroscientific Advances.
    Type of Medium: Online Resource
    Pages: XXXI, 673 p. 58 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031319860
    Series Statement: Advances in Experimental Medicine and Biology, 1425
    DDC: 612.8
    Language: English
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  • 21
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurology . ; Nanowires. ; Neuropharmacology. ; Neuroscience. ; Neurology. ; Nanowires. ; Neuropharmacology.
    Description / Table of Contents: Section I: Neurodegenerative diseases -- Chapter 1: Nanowired delivery of cerebrolysin together with antibodies to amyloid beta peptide, phosphorylated tau and tumor necrosis factor alpha induces superior neuroprotection in Alzheimer's disease brain pathology exacerbated by sleep deprivation -- Chapter 2: Nanodelivery of histamine H3/H4 receptor modulators BF2649 and clobenpropit with antibodies to amyloid beta peptide in combination with alpha synuclein reduces brain pathology in Parkinson's disease -- Chapter 3: Co-administration of nanowired DL-3-n-butylphthalide (DL-NBP) together with mesenchymal stem cells, monoclonal antibodies to alpha synuclein and TDP-43 (TAR DNA-binding protein 43) enhance superior neuroprotection in Parkinson's disease following concussive head injury -- Chapter 4: Neuroprotective effects of nanowired delivery of cerebrolysin with mesenchymal stem cells and monoclonal antibodies to neuronal nitric oxide synthase in brain pathology following Alzheimer’s disease exacerbated by concussive head injury -- Section II: Central Nervous system Trauma -- Chapter 5: Co-administration of nanowired monoclonal antibodies to inducible nitric oxide synthase and tumor necrosis factor-alpha together with antioxidant H-290/51 reduces SiO2-nanoparticles induced exacerbation of pathophysiology of spinal cord trauma -- Chapter 6: Nanowired delivery of cerebrolysin with mesenchymal stem cells attenuates heat stress induced exacerbation of neuropathology following brain blast injury -- Chapter 7: Co-administration of nanowired oxiracetam and neprilysin with monoclonal antibodies to amyloid beta peptide and p-tau thwarted exacerbation of brain pathology in concussive head injury at hot environment -- Section III. Stress and Drugs of abuse -- Chapter 8: Nanowired delivery of mesenchymal stem cells with antioxidant compound H-290/51 reduces exacerbation of methamphetamine neurotoxicity in hot environment -- Chapter 9: TiO2-nanowired delivery of Chinese extract of Gingko biloba EGb-761 and bilobalide BN-52021 enhanced neuroprotective effects of cerebrolysin following spinal cord injury at cold environment -- Chapter 10: Nanowired delivery of curcumin attenuates methamphetamine neurotoxicity and elevates levels of dopamine and brain derived neurotrophic factor.
    Abstract: This book covers the use of nanomedicine in the delivery of neuroprotective agents, including pharmacological drugs, stem cells, neurotrophic factors, monoclonal antibodies and enzymes to induce greater beneficial effects in neurologic diseases. Thus, the main purpose of the book is to explore the delivery of drugs either alone or in combination with stem cells to enhance neuroprotection in neurological diseases. Brain pathology associated with acute trauma such as head injury and brain blast injury can also be managed using novel treatment strategies. In addition, emphasis is made that standard patterns of brain pathology may be complicated with multiple comorbidity factors where one agent alone is not sufficient to induce brain protection. Enzymes and antibodies may help in combination and enhance the efficacy when administered through nanotechnology. Progress in Nanomedicine in Neurologic Diseases will encourage further research in the field of neuroprotection, brain injury, neurodegenerative diseases, neuropharmacology, neuropathology, and neurology. Students and researchers along with policy makers, teachers and health care professionals may also benefit from the findings of the book for enhanced patients care.
    Type of Medium: Online Resource
    Pages: XV, 418 p. 40 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031329975
    Series Statement: Advances in Neurobiology, 32
    DDC: 612.8
    Language: English
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  • 22
    Keywords: Neurosciences. ; Computational neuroscience. ; Biophysics. ; Science History. ; Neuroscience. ; Computational Neuroscience. ; Biophysics. ; History of Science.
    Description / Table of Contents: 1. Integrate and fire: RC circuits to model neurons and reward monkeys -- 2. Neuronal spike trains, stochastic point processes, and why George Gerstein’s papers are still worth reading -- 3. Visual Functions of Inferior Temporal Cortex -- 4. Early Days in the Gerstein Lab: Neuronal Plasticity in 1, 2, and 3 Dimensions -- 5. Patterns in Spike Trains -- 6. Introduction to the Gravity Papers -- 7. On correlations and interactions between neurons and with George Gerstein -- 8. Significance of Correlations between Spike Trains -- 9. Spatial-Temporal Spike Patterns -- 10. Does Cross Correlation Have a Unique Interpretation? -- 11. Neuronal Plasticity and my Experience Working with George L. Gerstein -- 12. Auditory Experiments and Modeling -- 13. Thinking about Analysis Methods with George in Philadelphia, Cambridge and Newcastle -- 14. Higher-order Correlations and Synfire Chains -- Nencki Award for George L. Gerstein.
    Abstract: This book brings together a selection of papers by George Gerstein, representing his long-term endeavor of making neuroscience into a more rigorous science inspired by physics, where he had his roots. Professor Gerstein was many years ahead of the field, consistently striving for quantitative analyses, mechanistic models, and conceptual clarity. In doing so, he pioneered Computational Neuroscience, many years before the term itself was born. The overarching goal of George Gerstein’s research was to understand the functional organization of neuronal networks in the brain. The editors of this book have compiled a selection of George Gerstein’s many seminal contributions to neuroscience--be they experimental, theoretical or computational--into a single, comprehensive volume .The aim is to provide readers with a fresh introduction of these various concepts in the original literature. The volume is organized in a series of chapters by subject, ordered in time, each one containing one or more of George Gerstein’s papers.
    Type of Medium: Online Resource
    Pages: XIII, 548 p. 253 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030874476
    Series Statement: Springer Series in Computational Neuroscience,
    DDC: 612.8
    Language: English
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  • 23
    Keywords: Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Description / Table of Contents: Soundscape – The Development of a New Discipline -- Soundscape: A Construct of Human Perception -- Soundscape: The Holistic Understanding of Acoustic Environments -- Soundscape and Urban Planning -- Architectural Soundscapes: Theories, Methods, and Practice -- Psychoacoustics in Soundscape Research -- Measurements and Techniques in Soundscape Research -- Triangulation as a Tool in Soundscape Research -- Soundscape and Health -- Hospital Soundscape -- How to Put Soundscape into Practice.
    Abstract: The concept of “Soundscape” includes all sounds in an environment and focuses on the interrelationship between person, activity and place, both in space and time. The goal of this volume is to present and review the developments in the field of Soundscape, reflecting standardization procedures and diverse applications. Soundscape – The Development of a New Discipline Brigitte Schulte-Fortkamp, and André Fiebig Soundscape: A Construct of Human Perception André Fiebig Soundscape: The Holistic Understanding of Acoustic Environments Brigitte Schulte-Fortkamp and Pamela Jordan Soundscape and Urban Planning Bennett M. Brooks Architectural Soundscapes: Theories, Methods, and Practice Gary W. Siebein, and Keely M. Siebein Psychoacoustics in Soundscape Research Klaus Genuit, Brigitte Schulte-Fortkamp, and André Fiebig Measurements and Techniques in Soundscape Research Giovanni Brambilla, and André Fiebig Triangulation as a Tool in Soundscape Research Dick Botteldooren, Bert De Coensel, and Francesco Aletta, Jian Soundscape and Health Peter Lercher, and Angel M. Dzhambov Hospital Soundscapes Ilene Busch-Vishniac, and Erica Ryherd How to Put Soundscape into Practice André Fiebig, andBrigitte Schulte-Fortkamp .
    Type of Medium: Online Resource
    Pages: XVII, 330 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031227790
    Series Statement: Springer Handbook of Auditory Research, 76
    DDC: 612.8
    Language: English
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  • 24
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Cytology. ; Zoology. ; Neurology . ; Neuroscience. ; Cell Biology. ; Zoology. ; Neurology.
    Description / Table of Contents: The Architecture of the Presynaptic Release Site.-Cytomatrix Proteins in Presynaptic Terminal. - Multiple Modes of Fusion and Retrieval at the Calyx of Held Synapse -- Roles of SNARE Proteins in Synaptic Vesicle Fusion -- Calcium Sensors of Neurotransmitter Release. - Roles and Sources of Calcium in Synaptic Exocytosis -- Regulation of Presynaptic Calcium Channels -- Roles of mUnc13/UNC-13 and mUnc18/UNC-18 in Neurotransmitter Release. - The role of tomosyn in the regulation of neurotransmitter exocytosis. -Roles of complexins in Neurotransmitter Release. -Regulation of Neurotransmitter Release by AIPR-1/AIP and calstabins. - The Role of Potassium Channels in the Regulation of Neurotransmitter Release -- Roles of Neuropeptides in Synaptic Function. - Transsynaptic Regulation of Presynaptic Release Machinery in Central Synapses by Cell Adhesion Molecules. - Lipids and Secretory Vesicle Exocytosis -- Synaptic Vesicle Endocytosis.
    Abstract: Neurons communicate with each other by releasing neurotransmitters. This book provides comprehensive coverage of the molecular mechanisms involved in neurotransmitter release. The topics covered in the book range from the architecture and cytomatrix proteins of presynaptic sites, to the modes of synaptic vesicle exocytosis (full-collapse and kiss-and-run), and from the key molecules mediating synaptic vesicle fusion (SNAREs) to those that closely interact with them (UNC-13/Munc13, UNC-18/Munc18, tomosyn, and complexins). The book also delves into the calcium sensors of synaptic vesicle fusion (synaptotagmins and Doc2s), the sources of calcium that trigger synaptic exocytosis (voltage-gated calcium channels and ryanodine receptors), and the regulation of neurotransmitter release by potassium channels, cell adhesion molecules, lipids, aryl hydrocarbon receptor-interacting protein (AIP), presenilins, and calstabins. To aid in understanding and illustrate key concepts, the book includes sufficient background information and a wealth of illustrations and diagrams. The new edition includes major updates to previous chapters, as well as several new chapters that reflect the recent advances in the field. Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release, 2nd edition, is a valuable learning resource for neuroscience students and a solid reference for neuroscientists.
    Type of Medium: Online Resource
    Pages: XI, 401 p. 77 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031342295
    Series Statement: Advances in Neurobiology, 33
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Cytology. ; Ecology . ; Neural circuitry. ; Neuroscience. ; Cell Biology. ; Ecology. ; Neural Circuits.
    Description / Table of Contents: 1. Introduction -- 2. Diversity and evolution of jellyfish visual systems, Mollusks -- 3. Scallops distributed eyes -- 4. Chiton dispersed visual systems, Annelids -- 5. Errant polychaetes Arthropods -- 6. Spider eyes -- 7. Myriapod eyes -- 8. Insect ocelli -- 9. Batflies, copepods or larval stomatopods -- 10 -- Hyperiid amphipods, Echinoderms -- 11. Brittle star vision -- 12. Starfish vision.
    Abstract: This volume explores the diversity of distributed eyes and other unusual visual systems in nature. It compares the unique themes of optics, neural processing, and behavioral control that emerge from these visual systems with more-canonical eyes. This volume attempts to answer a number of questions about distributed visual systems. What are distributed visual systems good for, how do they function, and why have they arisen independently in so many phyla? Why are eye designs and visual system arrangements much more diverse in invertebrates? Each chapter includes an overview of the visual systems that exist in their group of animals, relates vision to ecology, and takes a comparative approach. .
    Type of Medium: Online Resource
    Pages: VII, 320 p. 70 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031232169
    Series Statement: Springer Series in Vision Research,
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: Editorial -- Dystonia in childhood - how insights from paediatric research enrich the network theory of dystonia -- Focal Dystonia and the Stress-Network -- Limbic influences in Musicians dystonia -- Network perspective on task-specific dystonia -- Electromyography as a method for distinguising dystonia-like behavior in mice -- Deep brain stimulation of the interposed cerebellar nuclei in a mouse model of dystonia -- Applications of Transcranial Magnetic Stimulation for understanding and treating dystonia -- Brain connectivity in dystonia: evidence from Magnetoencephalography -- Dysfunctional networks in functional dystonia -- Collicular-pulvinar-amygdala axis and adult-onset idiopathic focal dystonia syndrome -- Neuromodulation in dystonia -- Electrophysiological properties of pallidal cells in cervical dystonia patients undergoing unilateral DBS -- Clinical implications of dystonia as a neural network disorder.
    Abstract: A recently proposed novel scheme of dystonia suggests that it is a disorder of neural network. Impairment in any of the “nodes” of the network may result in deficient network activity, causing dystonia. This book aims to present various experimental evidence supporting the network theory of dystonia. Dystonia is the abnormal twisting and turning of the organ and associated involuntary oscillations. Although dystonia is less common than Parkinson’s disease, traumatic brain injury, or stroke, each of these common disorders present with dystonia. Information regarding the brain regions that may be involved in dystonia is surprisingly limited and often conflicting. With chapters written by subject matter experts, this is a unique title that focuses on dystonia as a network disorder. This book would be of interest to basic and clinical researchers with an interest in motor systems and movement disorders.
    Type of Medium: Online Resource
    Pages: XI, 242 p. 37 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031262203
    Series Statement: Advances in Neurobiology, 31
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Neurology . ; Nervous system Diseases. ; Cognitive neuroscience. ; Neurophysiology. ; Learning Physiological aspects. ; Memory Physiological aspects. ; Neuroscience. ; Neurology. ; Neurological Disorders. ; Cognitive Neuroscience. ; Neurophysiology. ; Learning and Memory.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. The Psychiatrist and Pathologist Aloysius Alzheimer and His Seminal Findings -- Chapter 3. Alzheimer’s Disease Research After 1945: The Recommencement -- Chapter 4. Alzheimer’s Research Goes Deeper – Ultrastructural Electron Microscopy Studies -- Chapter 5. Focus on Neurochemistry Led to the Cholinergic Hypothesis of Alzheimer’s Disease -- Chapter 6. The Glutamatergic-Hypothesis of Alzheimer’s Disease -- Chapter 7. Biochemistry and Genetics Points Out a Prime Suspect for Causing Alzheimer’s Disease -- Chapter 8. Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor -- Chapter 9. Step by Step Towards an Amyloid Beta Peptide-Based Hypothesis of Alzheimer’s Disease -- Chapter 10. Concerns about the Amyloid Cascade Hypothesis and Reappraisals -- Chapter 11. Ignorance or Conspiracy? Or Just an Amyloid Firewall that Blocks Alternative Ideas? -- Chapter 12. In the Slip Stream of Amyloid: The Tau and Tangle Hypothesis -- Chapter 13. Focus on Tauopathies and Beyond -- Chapter 14. Alzheimer’s Research Gains Momentum and Spreads Out -- Chapter 15. The Amyloid Cascade Hypothesis Has to Deliver, Finally -- Chapter 16. Beyond APP, PSEN1, PSEN2, and APOE: What Else Does the Genome Tell Us? Chapter 17. Alternative Hypotheses and Observations that were Somehow Lost on the Way -- Chapter 18. Is the Persistence of the Amyloid Cascade Hypothesis a Result of Constant Confirmation Bias? -- Chapter 19. Driving Forces of Alzheimer’s Research Directions -- Chapter 20. Thirty Years after the Launch of the Amyloid Cascade Hypothesis: Is There a Shift of Gears at Last? -- Chapter 21. "If You Change the Way You Look at Things, Things You Look at Change".
    Abstract: This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer’s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer’s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer’s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer’s research community is finally ready to shed its ‘amyloid-straitjacket’ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer’s Disease research and provide a new and broader perspective on this age-dependent brain disease.
    Type of Medium: Online Resource
    Pages: XXV, 652 p. 116 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031315701
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Immunology. ; Ophthalmology. ; Neuroscience. ; Immunology. ; Ophthalmology.
    Description / Table of Contents: High Resolution Imaging Mass Spectrometry of Human Donor Eye: Photoreceptor Cells and Basal Laminar Deposits of Age-related Macular Degeneration -- The non-canonical role of Complement Factor H in Retinal Pigment Epithelium (RPE) cells and implications for Age-related Macular Degeneration -- Macular Pigment Carotenoids and Bisretinoid A2E -- Disturbed matrix metalloproteinases activity in age-related macular degeneraton -- Current views on Chr10q26 contribuiton to age-related macular degeneration -- Untargeted lipidomic profiling of aged human retina with and without age-related macular degeneration (AMD) -- Decoding Race and Age-Relation Macular Degeneration: GPR 143 Activity is the Key -- Peroxisome proliferator-activated receptor gamma coactivator 1 alpha ( PGC-1x): a transcriptional regulator at the interface of aging and age-related macular degeneration? -- Regulation of ABCA1 by miR-33 and miR-34a in the aging eye -- The role of gene expression regulation on genetic risk of Age-related Macular Degeneration -- Elastin layer in Bruch's membrane as a target for immunizatio or tolerization to modulate patthology in the mouse model of somke-induced ocular injury -- Repuprosing drugs for treatment of age-relation macular degeneration -- Extracellular Vesicle RNA Contents as Biomarkers for Ocular Diseases -- Proteomics of retinal extracellular vesicles: a reviw inot an unexplored mechanism in retinal health and AMD pathogenesis -- Prime Editing Strategy to Instally the PRHP2 c.828+1G A mutations -- Analysis of CRB1 Pathogenic Variants Correctable with CRISPR Base and Prime Editing -- Generation of an Avian Myeloblastosis Virus (AMV) Reverse Transcriptase Prime Editor -- Pre-existing neutralizing antibodies against different adeno-associated virus serotypes in humans and large animal models for gene therapy -- Optimization of Capillary-based Western Blotting for MYO7A -- AAV Serotypes and Their Suitability for Retinal Gene Therapy -- Gene Augmentation ofautosomal dominant CRX-associated retinopathies -- Txnip gene therapy of retinitis pigmentosa improves cone health Factors affecting readthrough of natural versus premature termination codons -- Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease -- Network biology and medcine to resuce: Applications for retinal disease mechanisms and therapy -- Non-sydromic Retinal Degeneration Caused by Pathogenic Variants in Joubert Syndrome Genes -- Exonic variants that affect splicing- an opportunity for "hidden" mutations causing inherited retinal diseases -- Enhanced S-cone Syndrome, a Mini-Review -- The role of microglia in Inherited Retinal Diseases -- CD68: potential contributor to inflammation and RPE cell dystrophy -- Gene Expression of Clusterin, Tissue Inhibitor of Metalloproteinase-1, and Their receptors in Retinal Pigment Epithelial Cells and Muller Glial Cells is Modulated by Inflammatory Stresses -- Axonal Transport Defects in Retinal Ganglion Cells -- Connexins biology in the pathophysiology of retinal diseases -- Role of Nuclear NAD +in Retinal Homeostasis -- Retinal pigmented epithelium-derived ectopic norrin does not promote intraretinal angiogenesis in transgenic mice -- Caveolin-1 Muller glia exist as heat-resistant,high molecular weight complexes -- Role of VLC-PUFAs in Retinal and Macular Degeneration -- Ocular amyloid , condensates, and aggregates - higher order protein assemblies participate in both retinal degeneration and function -- Photoreceptor ion channels in signaling and disease -- The role of peripherin-2 /ROM1 complexes in photoreceptor outer segment disc morphogenesis -- Human mutations in Arl3, a small GTPase involved inlipidated cargo delibery to the cilia cause retinatl dystropthy -- Genotype-Phenotype Association in ABCA4-Associated Retinopathy -- Retinal pathoconnectomics: A Window into Neurodegeneration -- The role of Ceramide in Inherited Retinal Disease Pathology -- Extracelluar Matix: the Unexplored Aspects of Retinal Pathologies and Regeneration -- Role of TFEB in diseases assocaited with lysosomal dysfunction -- Retinoic acid receptor -related oprhan receptors (RORs) in eye development and disease -- A novel mouse model for Late-Onset Retinal Degeneration (L-ORD) devekios RPE abnormalities due to the loss of C1qtnf5/Ctrp5 -- Comparison of mouse models of autosomal dominant retinitis pigmentosa due to P23H muations of Rhodopsin -- Compensatory Cone-Mediated Mechanisms in Inherited Retinal Degeneration Mouse Models: A Functional and Gene Expression Analsyis -- Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Sress and Promotes ER Protein Degradation in Cyclic Nucleotide-gated Channel Deficiency -- Mouse choroid proteome revisited: foucs on aging -- Morphological and functional comparison of mice models for retinitis pigmentosa -- Current Advancements in Mouse Models of Retinal Disease -- Single-cell Itrnacriptomic Profiling of Muller Glia in the rd10 Retina -- Methods for in vivo characterization of proteostatis in the mouse retina -- Absence or PRCD leads to dysregulation in lipie Homeostatis resulting in disorganizationof photorecptor outer segment structure -- Expansion Microscopy of Mouse Photoreceptro Cilia -- Rod photorecptor specific ablation of Metformin target, AMPK, in preclinical model of autosomal recessvie retinitis pigmentosa -- TLR2 is highly overexpressed in retinal myeloid cells in the rd10 mouse model of retinitis pigmentosa -- Environmental light has an essentail effrect on the diseasae expression in a dominant RPE65 mutation -- Microglia Preserve Visual Function in A Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant -- Measuring the release of lactate from wild-type and rd1 mouse retina -- Aerobic glycolysis in photorecptors supports energy demand in the absence of mitochondrial coupling -- Redox Status in Retinitis Pigmentosa -- Perspectives on retinal dolichol metabolism and visual deficits in dolichol metalbolism-associated inherited disorders -- Retinal metabolic profile on IMPG2 deficiency mice with subretinal lesions -- Glutathione-coating of liposomes enhances the delivery of hydrophillic cargo to the inner nuclear layer in retinal cultures -- Modification of Mueller glial cell fate and proliferation with the use of small molecules -- A potential neuroprotective role for pyruvate kinase 2 in retinal degeneration -- Critical role of VEGF as a direct regulator of photorecptor function -- Lysine Ubiquitylation Drives Rhodopsin Protein Turnover -- In-silico prediction of MYO!C Rhodopsin Interactions and its Significance in Protein Localization and Visual Function -- A ciliary branched actin netowrk drives photoreceptor disc morphogenesis -- Revisiting the daily timing of POS phagocytosis -- Inhibition of Bacterial Peoptidoglycan Cytopahty by Retina Pigment Epithelial PGRP2 Amidase -- Understanding ischemic retinopathies: the role of Succinate and its recpto^T mutation -- Inducing neural regeneratio nfrom glia using proneural bHLH transcription factors.
    Abstract: This book contains the proceedings of the XIX International Symposium on Retinal Degeneration. A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. These retinal degeneration symposia are known by most as the “best” and “most important” meetings in the field. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. We anticipate that the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.
    Type of Medium: Online Resource
    Pages: XIX, 588 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031276811
    Series Statement: Advances in Experimental Medicine and Biology, 1415
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Neurochemistry. ; Medicine Research. ; Biology Research. ; Regenerative medicine. ; Neuroscience. ; Neurochemistry. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: The Purinergic Signaling: Overview -- Adenosine A2A Receptor-containing Heteromers and Neuroprotection -- Purinergic Signaling in Brain Physiology -- Neurotrophic Actions of Adenosine and Guanosine: Implications for Neural Development and Regeneration? -- Purinergic Signaling in Neurogenesis and Neural Fate Determination: Current Knowledge and Future Challenges -- Purinergic Signaling in Autism Spectrum Disorder -- Purinergic Signaling in Depression -- Roles of Purinergic Receptors in Alzheimer's Disease -- Purinergic Signaling in Basal Ganglia Diseases: Parkinson's Disease -- A Step in the ALS Direction: Lessons from the Purinome -- Purinergic P2 Receptors in Epilepsy -- Purinergic Signaling in Neuroinflammation -- Purinergic Signaling in Brain Tumors -- Development of Purinergic Receptor Agonists and Antagonists -- Acupuncture for Counteracting P2X4 and P2X7 Receptor Involvement in Neuroinflammation.
    Abstract: This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson’s, and Alzheimer’s disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.
    Type of Medium: Online Resource
    Pages: X, 376 p. 34 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031269455
    DDC: 612.8
    Language: English
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    Keywords: Psychobiology. ; Human behavior. ; Cognitive neuroscience. ; Psychology, Experimental. ; Behavioral Neuroscience. ; Cognitive Neuroscience. ; Experimental Psychology.
    Description / Table of Contents: The promises and pitfalls of Virtual Reality -- Setting up your VR neuroscience laboratory -- Monitoring the autonomic system in VR -- Monitoring brain activity in VR: EEG and neuroimaging -- Eye-tracking and Pupillometry in VR -- VR for Movement and Action Science -- VR for Vision Science -- VR for Emotion -- VR for Thinking and Creativity -- VR for Social Cognition -- VR as a window into Consciousness -- Aging -- Learning -- Pain -- Cognitive and motor rehabilitation -- VR for Mental Health.
    Abstract: Virtual Reality (VR) is a rapidly maturing technology that offers new and unique solutions to otherwise intractable problems in the study of cognition, behavior and neuroscience. VR removes many of the constraints imposed by laboratory paradigms, allowing us to track cognitive, behavioral and brain responses to naturalistic (or even impossible) situations without sacrificing experimental control. But VR is not a tool that can be swiftly and effortlessly integrated into existing research pipelines; currently, the benefits of VR are accompanied by a host of methodological challenges and important practical considerations. To help navigate this new methodology, this volume provides a balanced review of both the exciting new findings emerging from VR labs and the challenges and limitations that are part and parcel of VR research. This volume is an important first step toward establishing a standardised methodology for conducting research in VR. To this end, the volume provides a wealth of practical advice for researchers who are new to the technology. This volume is authored by an interdisciplinary team of VR researchers including computer scientists, engineers, psychologists and neuroscientists. It highlights current research in the field to demonstrate how VR advances our understanding of the mind, while also providing groundbreaking solutions in applied domains.
    Type of Medium: Online Resource
    Pages: X, 387 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031429958
    Series Statement: Current Topics in Behavioral Neurosciences, 65
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Biomedical engineering. ; Nanotechnology. ; Biophysics. ; Imaging systems in biology. ; Neuroscience. ; Biomedical Engineering and Bioengineering. ; Nanoengineering. ; Bioanalysis and Bioimaging. ; Biological Imaging.
    Description / Table of Contents: Part 1 -- Optically-Pumped Magnetometers Compatible with Large Transient Magnetic Fields -- Small animal biomagnetism applications -- Supine OPM-MEG in Multi-layer Cylindrical Shield -- Ambulatory MEG Arrays -- Part 2 -- "Tri-axial helium-4 optically-pumped -- magnetometers for MEG" -- Person-Sized Magnetoencephalography Systems with Optically Pumped Magnetometers -- On-scalp MEG with High-Tc SQUIDs -- "Fiber Coupled OPM in Purely Coil -- Shielded Environment" -- SERF-OPM usability for MEG in two-layer shielded rooms -- Turning OPM-MEG into a Wearable Technology -- Part 3 -- OPM Gradiometer for Magnetorelaxometry -- Unshielded High Bandwidth Magnetorelaxometry of Magnetic Nanoparticles with Optically Pumped Magnetometers -- Adult Magnetocardiography: Principles and Clinical Practice -- Fetal Magnetocardiography with OPMs -- Emerging MR sensors for biomagnetic measurements -- Index.
    Abstract: This contributed volume reviews the latest advances in all the new technologies currently developed for MagnetoEncephaloGraphy (MEG) recordings, as well as sensor technologies and integrated sensor arrays for on-scalp MEG. The book gives an account of the first MEG imaging studies and explores the new field of feasible, experimental paradigms of on-scalp MEG. This is an ideal book for engineers, researchers, and students in the neurosciences interested in MEG imaging. .
    Type of Medium: Online Resource
    Pages: IX, 315 p. 104 illus., 88 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031053634
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Animal culture. ; Veterinary medicine. ; Neuroscience. ; Animal Science. ; Veterinary Science.
    Description / Table of Contents: Rodents -- Carnivores -- Sheep and goats -- Swine -- Rabbits -- Bovines -- Non-human primates -- Humans -- Squirrels.
    Abstract: Modern neuroscience has presented new opportunities for exploring the molecular and neural mechanisms controlling specific social responses. This book reviews insights into the neural circuits underlying a particularly fascinating form of social interaction, parental behavior. This book presents a detailed review of maternal and paternal behavior of particular mammalian species. It offer neuroscientists a spectrum of specific mammals that can be used as experimental models to explore particular topics on the functions of the nervous system. It shows that results coming from the laboratory can be translated into useful information for raising mammals on the farm, and it stimulates biologists to gain insights into the underpinnings of the complex mechanisms governing mammalian behavior in the wild. It also discusses the implications of this research for human parental behavior. .
    Type of Medium: Online Resource
    Pages: V, 309 p. 45 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030977627
    Series Statement: Advances in Neurobiology, 27
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Cognitive neuroscience. ; Social evolution. ; Neuroscience. ; Cognitive Neuroscience. ; Social Evolution.
    Description / Table of Contents: Part I Differentiation-Integration Dynamics: Ultimate Causes -- Chapter 1: Introduction -- Chapter 2: Purposeless Design -- Chapter 3: Darwinian Evolutionary Theory -- Chapter 4: Principles of Differentiation and Integration -- Chapter 5: The Information Trend in Science -- Chapter 6: Is Social Cohesion a Different Mechanism of Evolution? -- Part II Roots and Mechanisms: Proximate Causes -- Chapter 7: Fundamental Physical Forces, Genes, and Epigenetics -- Chapter 8: Biological Origins -- Chapter 9: Neural Mechanisms of Sociality -- Chapter 10: Psychological Features -- Chapter 11: Cognitive Science Underpinnings -- Chapter 12: A Sociological Systems Theory -- Chapter 13: Developmental Roots -- Chapter 14: Metaphysical, Religious, and Spiritual Aspects -- Part III Survival Value -- Chapter 15: Sociality’s Survival Value -- Part IV Conclusions -- Chapter 16: A New Framework: A Theory of Integration.
    Abstract: This book is an exploration of the integration-differentiation dynamics that result in a drive, or impulse, toward human sociality, arguing that our need to connect with other people is as fundamental as our need for food and shelter. In The Social Impulse: The Evolution and Neuroscience of What Brings Us Together, Jaime Pineda presents the evidence that social cohesion is a complementary force to natural selection, the Darwinian drive for differentiation and diversity. The book addresses the distinctive aspects of social behavior that arise from integration principles and seeks to answer the following questions: (1) Why does social cohesion arise? (2) What is the history of social dynamics? (3) How does social cohesion work? (4) When do the developmental aspects of social dynamics arise? A final section of the book addresses the value of sociality and social cohesion. By exploring the differences, similarities, and, most important, the interactivity between natural selection and social cohesion, this unique book provides a wealth of interesting, challenging, and unexpected insights.
    Type of Medium: Online Resource
    Pages: XXV, 190 p. 7 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031084393
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Pain medicine. ; Clinical psychology. ; Neuroscience. ; Pain Medicine. ; Clinical Psychology.
    Description / Table of Contents: Chapter 1. Conceptualising Pain in Critically-Ill Neonates or Infants -- Chapter 2. Pain in the Fetus and the Preterm Baby -- Chapter 3. Developmental Influences on the Meanings of Pain in Children -- Chapter 4. “Ooh, You Got to Holler Sometime:” Pain Meaning and Experiences of Black Older Adults -- Chapter 5. Exploring the Meaning of Chronic Low Back Pain as a Life of ‘Living Death’ in Rural Nigeria -- Chapter 6. Painworld: A Phenomenological View of Veteran Experiences of Living with Chronic Pain -- Chapter 7. “It’s Just One of Them Things You’ve Got to Try and Manage”: Meanings of Pain for People with Brain Injury.
    Abstract: This book, the third and final volume in the Meaning of Pain series, describes what pain means to people with pain in “vulnerable” groups, and how meaning changes pain – and them – over time. Immediate pain warns of harm or injury to the person with pain. If pain persists over time, more complex meanings can become interwoven with this primitive meaning of threat. These cognitive meanings include thoughts and anxiety about the adverse consequences of pain. Such meanings can nourish existential sufferings, which are more about the person than the pain, such as loss, loneliness, or despair. Although chronic pain can affect anyone, there are some groups of people for whom particular clinical support and understanding is urgently needed. This applies to “vulnerable” or “special” groups of people, and to the question of what pain means to them. These groups include children, women, older adults, veterans, addicts, people with mental health problems, homeless people, or people in rural or indigenous communities. Several chapters in the book focus on the lived experience of pain in vulnerable adults, including black older adults in the US, rural Nigerians, US veterans, and adults with acquired brain injury. The question of what pain experience could mean in the defenceless fetus, neonate, pre-term baby, and child, is examined in depth across three contributions. This book series aspires to create a vocabulary on the “meanings of pain” and a clinical framework with which to use it. It is hoped that the series stimulates self-reflection about the role of meaning in optimal pain management. Meanings of Pain is intended for people with pain, family members or caregivers of people with pain, clinicians, researchers, advocates, and policy makers. Volume I was published in 2016; Volume II in 2019.
    Type of Medium: Online Resource
    Pages: VII, 147 p. 5 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030958251
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. The Auditory Cognitive Neuroscience of Speech Perception in Context -- 2. Subcortical Processing of Speech Sounds -- 3. Cortical Representation of Speech Sounds: Insights from Intracranial Electrophysiology -- 4. A Parsimonious Look at Neural Oscillations in Speech Perception -- 5. Extracting Language Content From Speech Sounds: The Information Theoretic Approach -- 6. Speech Perception under Adverse Listening Conditions -- 7. Adaptive Plasticity in Perceiving Speech Sounds -- 8. Development of Speech Perception -- 9. Interactions Between Audition and Cognition in Hearing Loss and Aging.
    Abstract: This volume reviews contemporary developments in the auditory cognitive neuroscience of speech perception, including both behavioral and neural contributions. It serves as an important update on the current state of research in speech perception. The Auditory Cognitive Neuroscience of Speech Perception in Context Lori L. Holt, and Jonathan E. Peelle Subcortical Processing of Speech Sounds Bharath Chandrasekaran, Rachel Tessmer, and G. Nike Gnanateja Cortical Representation of Speech Sounds: Insights from Intracranial Electrophysiology Yulia Oganian, Neal P. Fox, and Edward F. Chang A Parsimonious Look at Neural Oscillations in Speech Perception Sarah Tune, and Jonas Obleser Extracting Language Content From Speech Sounds: The Information Theoretic Approach Laura Gwilliams, and Matthew H. Davis Speech Perception under Adverse Listening Conditions Stephen C. Van Hedger, and Ingrid S. Johnsrude Adaptive Plasticity in Perceiving Speech Sounds Shruti Ullas, Milene Bonte, Elia Formisano, and Jean Vroomen Development of Speech Perception Judit Gervain Interactions Between Audition and Cognition in Hearing Loss and Aging Chad S. Rogers, and Jonathan E. Peelle .
    Type of Medium: Online Resource
    Pages: XVI, 252 p. 33 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030815424
    Series Statement: Springer Handbook of Auditory Research, 74
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Psychobiology. ; Human behavior. ; Behavioral Neuroscience.
    Description / Table of Contents: Part I Preclinical Research: Neuroendocrine Mechanisms of Social Bonds and Separation Stress in Rodents, Dogs, and Other Species -- Methods and Challenges in Investigating Sex-Specific Consequences of Social Stressors in Adolescence in Rats: Is It the Stress or the Social or the Stage of Development?- Social stress-induced neuroinflammation and mitochondrial dysfunction as a link to depression and cardiovascular disease comorbidity -- Mean Girls: Social Stress Models for Female Rodents -- Development of Mixed Anxiety/ Depression-Like State as a Consequence of Chronic Anxiety: Review of Experimental Data -- Unravelling the Neuroinflammatory Mechanisms Underlying the Effects of Social Defeat Stress on Use of Drugs of Abuse -- Social Stress and Aggression in Murine Models -- More or less: glucocorticoid roles in aggression -- Neurobiological Bases of Urges for Alcohol Consumption After Social Stress -- Epigenetics of Aggression -- Part II Human Research: Early Life Stress and Neurodevelopment in Adolescence: Implications for Risk and Adaptation -- Effects of Parenting Environment on Child and Adolescent Social-Emotional Brain Function -- The Stressed Brain: Neural Underpinnings of Social Stress Processing in Humans -- Social Acts and Anticipation of Social Feedback -- Clinical Outcomes of Severe Forms of Early Social Stress -- Childhood Violence Exposure, Inflammation, and Cardiometabolic Health -- Social Support Effects on Neural Stress and Alcohol Reward Responses -- Neural Underpinnings of Social Stress in Human Addiction.
    Abstract: Social stress has emerged as a research front in the neurosciences, and this volume highlights recent insights in brain mechanisms and methodological advances. The topics range from the evolutionary origins of coping with social challenges to neural mechanism-driven focus on novel treatment targets. The parallel presentation of work with animal models and human subjects is bound to be useful to a broad research community.
    Type of Medium: Online Resource
    Pages: VIII, 515 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031042560
    Series Statement: Current Topics in Behavioral Neurosciences, 54
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Psychiatry. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: Section I. Anhedonia – History, Etiology, and Assessments -- 1. Historical Perspective -- 2. Clinical and Behavioral Assessments -- 3. Developmental Trajectories: Preclinical -- 4. Developmental Trajectories: Clinical -- 5. Genetics Contributions -- 6. Environmental Contributions -- Section II. Anhedonia in Psychiatric and Neurological Disorders -- 7. Depression and Bipolar Disorder -- 8. Schizophrenia -- 9. Substance Use Disorder -- 10. Nicotine Dependence -- 11. Posttraumatic Stress Disorder -- 12. Anxiety -- 13. Eating Disorders -- 14. Autism and Developmental Disorders -- 15. Neurodegenerative Disorders -- Section III. Reward Processing Systems in Anhedonia -- Reward Responsiveness -- 16. Pleasure -- 17. Anticipation -- Reward Valuation -- 18. Reward Value – Delay and Reward Magnitude -- 19. Effort/Motivation -- Reward Learning -- 20. Reward Prediction Error -- 21. Probabilistic and Reinforcement Learning -- Section IV. Treatments -- 22. Pharmacological Treatments for Anhedonia -- 23. Psychological Treatments for Anhedonia -- 24. Neurostimulation -- Section V. Special Topics -- 25. Inflammation and Anhedonia -- 26. Computational Modeling of Anhedonia -- 27. Anhedonia and Suicide.
    Abstract: Anhedonia is a key symptom (and often risk factor) for various neuropsychiatric disorders, including depression, schizophrenia, substance use disorders, post-traumatic stress disorders, and Parkinson's Disease, among others. Across disorders, anhedonia has been associated with worse disease course, including poor response to pharmacological, psychological and neurostimulation treatments as well as completed suicide. Mounting evidence emerging from preclinical and translational sciences has clarified that "anhedonia" can be parsed into partially independent subcomponents, including incentive motivation, consummatory pleasure, reward learning, and effort-based decision making, pointing to distinct neurobiological substrates that could underlie anhedonic phenotypes. Taking an integrative approach that emphasizes cross-species integration and dimensional conceptualization of mental illnesses (e.g., Research Domain Criteria (RDoC)), this book represents the most comprehensive evaluation, synthesis and integration of theories and empirical findings focused on anhedonia. Organized across five parts, the handbook starts with chapters on the history, etiology, and assessments of anhedonia (Part I), followed by a section on the role of anhedonia in psychiatric and neurological disorders (Part II). Using the RDoC Matrix as a guide, Part III presents chapters synthetizing preclinical and clinical findings on different reward processing subdomains (e.g., reward responsiveness, reward valuation, reward learning). Part IV is focused on selected special topics, including historical and current perspectives on the transdiagnostic nature and importance of social anhedonia, the role of inflammation in the pathophysiology of anhedonia, the use of computational modeling to “dissect” anhedonia and improve its understanding, and links between anhedonia and suicide. Finally, Part V includes chapters on pharmacological, psychological and neurostimulation treatments for anhedonia.
    Type of Medium: Online Resource
    Pages: XI, 535 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031096839
    Series Statement: Current Topics in Behavioral Neurosciences, 58
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Psychobiology. ; Human behavior. ; Pharmacology. ; Psychiatry. ; Pain medicine. ; Neuroscience. ; Behavioral Neuroscience. ; Pharmacology. ; Psychiatry. ; Pain Medicine.
    Description / Table of Contents: CLINICAL PROFILE AND TREATMENTS -- ADHD in children and adults: diagnosis and prognosis -- Treatment strategies -- Psychostimulants – treatment efficacy and problems -- Recent developments and future options for pharmacological treatments for ADHD -- GENETICS -- Genetics of ADHD (including CNVs) -- Genes , cognitive function and ADHD -- Epigenetics and ADHD -- CO-MORBIDITY -- ADHD and comorbid depression -- ADHD and autism -- Aggression and ADHD -- Obesity and ADHD (+ cytokines?) -- Sleep circadian rhythms and ADHD -- Substance misuse -- ASSESSING BRAIN FUNCTION / DYSFUNCTION -- EEG and ADHD (the skeptical view) -- Update on imaging – with connectivity -- Visual processing substrates for ADHD -- Cortical microstructure / connectivity -- ANIMAL AND IN VITRO STUDIES -- Critique of animal models -- Update on circuits for impulsive behaviour -- Zebrafish -- Update on DA transporter and ADHD -- Arousal, noradrenaline and ADHD -- FUTURE DIRECTIONS -- Stem cells for disease modelling -- Microbiome and ADHD -- Adult ADHD.
    Abstract: New Discoveries in the Behavioral Neuroscience of Attention Deficit Hyperactivity Disorder reviews the latest developments in preclinical and clinical research of Attention Deficit Hyperactivity Disorder. As well as updating key chapters that were included in an earlier edition, this volume includes some new topics that are attracting a great deal of interest and point the way to new and promising directions for future research. The chapters follow five main themes: Current perspectives on the clinical profile of ADHD and its treatment, common co-occurring conditions, neurobiological studies examining brain function and genetics, animal and in vitro studies, and future directions. This combination of topics emphasises the translational relevance and validity of preclinical research so as to enable a better understanding of ADHD and to highlight the promising strategies for developing new treatments.
    Type of Medium: Online Resource
    Pages: VIII, 501 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031118029
    Series Statement: Current Topics in Behavioral Neurosciences, 57
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Cognitive psychology. ; Neuropsychology. ; Psychiatry. ; Philosophy of mind. ; Neurology . ; Neuroscience. ; Cognitive Psychology. ; Neuropsychology. ; Psychiatry. ; Philosophy of Mind. ; Neurology.
    Description / Table of Contents: Learning the Languages -- Humanity’s Search for Mind and the Subject: A Brief Review of the Evolution of Neuropsychobiology -- An “Ideographic,” Suprapersonal Language of Rules and Universal Symbols: Alwyn Scott and Nonlinear Dynamics -- A “Demotic,” First-Person Language of the Individual and the Social System: Apuleius and the Myth of Psyche -- The Language of the Objective Observer: Gerald Edelman and Neurodarwinism: Antonio Damasio and the Feeling of Knowing -- Seeking the Understanding -- Consciousness -- The Unconscious -- The Database -- Affectivity -- The Neural/Mental Gap: Intuition, Self and Ego, a Trilingual Map -- Applying the Knowledge -- The Three Languages and Science: A New Scientific Paradigm? -- The Three Languages and Treatment -- The Psychotherapeutic Dialogue: Intersubjectivity -- The Role of a New Science for Psyche Upon Society and Culture.
    Abstract: The study of the brain-mind complex has been hampered by the dichotomy between objective biological neuroscience and subjective psychological science. The two antithetical avenues of research are partly responsible for the failure to unravel the transformation of neural events into mental images: how matter becomes imagination, and vice versa; is the brain’s consciousness equivalent to Ego consciousness? Is the ego the self? In its new and updated edition, “The Rosetta Stone of the Human Mind: Three Languages to Integrate Neurobiology and Psychology” illustrates how the simultaneous use of the languages of neurobiology, of mathematics, and of the humanities, enriches the understanding of the neural and mental realms and adds new dimensions to our perception of neuropsychological events. Dr. Sanguineti shows how the two seemingly dichotomous approaches are similar in what they describe, and he explores how the awareness and application of these perspectives are helpful in getting a deeper theoretical grasp on major mental events, giving us a better understanding of individual minds, and fostering a more integrated therapeutic intervention. The intended readers include neuroscientists, psychiatrists, psychologists, and anyone interested in the human mind. Describes a model integrating biological neuroscience principles, subjective psychological science, and nonlinear physics and mathematics Offers a wide-ranging, holistic exploration of the mind and its conscious and unconscious realms, using myth, art, philosophy, neurobiology and basic sciences Introduces the future new paradigm for emergent science, the Poem, to replace the outdated classical reductionistic paradigm of the Machine.
    Type of Medium: Online Resource
    Pages: XXII, 167 p. 25 illus., 6 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030864156
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurology . ; Neuropsychology. ; Pharmacology. ; Neuropharmacology. ; Psychiatry. ; Neuroscience. ; Neurology. ; Neuropsychology. ; Pharmacology. ; Neuropharmacology. ; Psychiatry.
    Description / Table of Contents: Treatments Against Glutamatergic Excitotoxicity in Ischemic Stroke -- Definitions and Concepts of Stress -- Role of Glutamatergic Neurotransmission in the Pathophysiology of Stress-Related Disorders and Chronic Stress Response -- Current Glutamatergic Treatments and Future Directions for Glutamate-Based Management of Chronic Stress and Stress-Related Disorders -- The Role of the Glutamate System in Posttraumatic Stress Disorder and Glutamate-Based Treatments -- Glutamate in Migraine Neurobiology and Treatment -- Astrocyte Glutamate Transporter EAAT2 in Alzheimer Dementia -- The Glutamatergic System as a Target for the Development of New Pharmacological Treatments of Bipolar Disorder -- CNS Glutamate in Impulsive Aggression -- Glutamatergic Treatments for Parkinsons' Disease -- The Modulation of Glutamatergic Signaling as a Potential Therapeutic Strategy for Major Depression -- Glutamate-Based Treatment for Amyotrophic Lateral Sclerosis/Motor Neuron Disease -- Modulation of Glutamate for Chronic Pain Management -- Pharmacological Role of Glutamate Transporters in Substance Use Disorders -- Glutamate in Multiple Sclerosis: From Pathophysiology to Treatments -- The Role of Glutamate Dysregulation in the Etiology of ADHD -- Glutamate, Glutamatergic Drugs and Schizophrenia -- Glutamate and Epilepsy: An Insight from Temporal Lobe Epilepsy -- Glutamate Function in Anxiety Disorders and OCD: Evidence from Clinical and Translational Studies -- Modulators of Glutamatergic Signaling as Potential Treatments for Autism Spectrum Disorders.
    Abstract: This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.
    Type of Medium: Online Resource
    Pages: XXXV, 600 p. 43 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030874803
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Neural circuitry. ; Bioinformatics. ; Computer science. ; Neuroscience. ; Neural Circuits. ; Computational and Systems Biology. ; Computer Science.
    Description / Table of Contents: PART I. Cellular Scale -- Chapter 1. Modelling Neurons in 3D at the Nanoscale -- Chapter 2. Modelling Dendrites and Spatially-Distributed Neuronal Membrane Properties -- Chapter 3. A User's Guide to Generalized Integrate-and-Fire Models -- Chapter 4. Neuron-glia Interactions and Brain Circuits -- Chapter 5. Short-term Synaptic Plasticity: Microscopic Modelling and (some) Computational Implications -- PART II. Molecular Scale -- Chapter 6. The Mean Field Approach for Populations of Spiking Neurons -- Chapter 7. Multidimensional Dynamical Systems with Noise -- Chapter 8. Computing Extracellular Electric Potentials from Neuronal Simulations -- Chapter 9. Bringing Anatomical Information into Neuronal Network Models -- PART III. Network Scale -- Chapter 10. Computational Concepts for Reconstructing and Simulating Brain Tissue -- Chapter 11. Reconstruction of the Hippocampus -- Chapter 12. Challenges for Place and Grid Cell Models -- Chapter 13. Whole-Brain Modelling: Past, Present, and Future.
    Abstract: This volume offers an up-to-date overview of essential concepts and modern approaches to computational modelling, including the use of experimental techniques related to or directly inspired by them. The book introduces, at increasing levels of complexity and with the non-specialist in mind, state-of-the-art topics ranging from single-cell and molecular descriptions to circuits and networks. Four major themes are covered, including subcellular modelling of ion channels and signalling pathways at the molecular level, single-cell modelling at different levels of spatial complexity, network modelling from local microcircuits to large-scale simulations of entire brain areas and practical examples. Each chapter presents a systematic overview of a specific topic and provides the reader with the fundamental tools needed to understand the computational modelling of neural dynamics. This book is aimed at experimenters and graduate students with little or no prior knowledge of modelling who are interested in learning about computational models from the single molecule to the inter-areal communication of brain structures. The book will appeal to computational neuroscientists, engineers, physicists and mathematicians interested in contributing to the field of neuroscience. Chapters 6, 10 and 11 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. .
    Type of Medium: Online Resource
    Pages: XII, 359 p. 115 illus., 94 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030894399
    Series Statement: Cellular Neuroscience, Neural Circuits and Systems Neuroscience, 1359
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: Establishing the molecular and functional diversity of spinal motoneurons -- Chloride homeostasis in developing motoneurons -- Normal development and pathology of motoneurons: anatomy, electrophysiological properties, firing patterns and circuit connectivity -- Homeostatic regulation of motoneuron properties in development -- Homeostatic plasticity of the mammalian neuromuscular junction -- Diversity of mammalian motoneurons and motor units -- Synaptic projections of motoneurons within the spinal cord -- Recruitment of motoneurons -- Electrical properties of adult mammalian motoneurons.-The cellular basis for the generation of firing patterns in human motor units -- Motoneuronal regulation of central pattern generator and network function -- Extraocular motoneurons and neurotrophism -- Motoneuron diseases -- Electrical and morphological properties of developing motoneurons in postnatal mice and early abnormalities in sod1 transgenic mice -- From physiological properties to selective vulnerability of motor units in amyotrophic lateral sclerosis. .
    Abstract: This book aims to provide a comprehensive and timely review of new findings in motoneuron research. Recent findings have revealed that motoneurons are more complex and have more extensive functions than previously imagined. Some of the molecular and genetic pathways that orchestrate the development of motoneurons have been discovered, as have the mechanisms responsible for the selective innervation of muscles by specific pools of motoneurons. These novel findings are revolutionizing ideas about the function of motoneurons and have important implications for motoneuron disease. Chapters from several of the foremost figures in the field are included in this book and will emphasize how basic science is the engine driving the discovery of novel treatments for degenerative motoneuron diseases. Cutting edge developments in the use of pluripotent stem cells to correct motoneuron disease will be also be covered. This book would be useful to students of basic motoneuron physiology, locomotor behavior and motor control. This book would also be of interest to professional neuroscientists, neurologists, and neurosurgeons.
    Type of Medium: Online Resource
    Pages: XII, 400 p. 81 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031071676
    Series Statement: Advances in Neurobiology, 28
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurophysiology. ; Gastroenterology. ; Neuroscience. ; Neurophysiology. ; Gastroenterology.
    Description / Table of Contents: Luminal Chemoreceptors and Intrinsic Nerves -- Key Modulators of Digestive Motor Function -- Comparative and evolutionary aspects of the ENS -- Exploring synaptic transmission in the ENS: electrophysiology, functional studies and modelling -- Mucosal Serotonin5 -- Ca2+ signaling in Interstitial cells of Cajal: The mechanistic basis for many GI motility behaviors -- Identifying types of neurons in the enteric nervous systes -- Clinico-Pathological Features of severe gut dysmotility -- Purinergic signaling in the ENS -- Myogenic and neural control in concert -- colonic response to physiological and chemical stimuli -- Molecular targets to alleviate enteric neuropathy and gastrointestinal dysfunction -- The emerging role of the gut-brain microbiota axis in neurodevelopmental disorders -- A view on how enteric neurons monitor luminal content -- Interaction of the microbiota and the developing ENS -- Influence of the circadian rhythm on enteric nervous system function -- Mechanosensitive Enteric Neurons (MEN) at work -- Neurogenetic investigation of the ENS and gut motility -- The shaggy dog story of enteric signaling: serotonin, a molecular megillah -- Contribution of enteric neuroglial remodelling to inflammatory bowel disease and cancer evolution -- Examining cellular metabolism in the enteric nervous system -- Embryonic development of motility: a bottom-up approach to the workings of the intestine -- Quantitative analysis of intestinal movements with spatiotemporal maps -- The roles of Mas related G-protein coupled receptors in the gut -- Refining Enteric Neural Circuitry by Quantitative Morphology, Transcriptomics and Function in Mice” -- Extrinsic modulation of enteric circuits that regulate colon function in health and disease -- Activating and Modeling ENS Circuits in Mouse Colon -- Neurons, macrophages and glia: the role of intercellular communication for gut motility -- Modelling development of the ENS: What's been done and what's next -- Epithelial 5-HT4 receptors as a target for treating constipation and colitis -- Activity in Enteric Neural circuits underlying propulsion -- Contribution of the ENS to autoimmune diseases and irritable bowel syndrome.
    Abstract: This book is based on the proceedings of the Enteric Nervous System conference in Adelaide, Australia, as part of the International Federation for Neurogastroenterology and Motility. The book focuses on methodologic strategies and unresolved issues in the field and explores where the future is heading and what technological advances have been made to address current and future questions. The Enteric Nervous System II continues in the tradition of a popular earlier volume which covered the previous meeting. Many of the same authors are contributing to this new volume, presenting state-of-the-art updates on the many developments in the field since the earlier meeting. The coverage include a wide range of topics, from structure and function of the enteric nervous system through gut motility and visceral pain. The author team includes long-established authorities who significantly contributed to the advances in ENS research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field. .
    Type of Medium: Online Resource
    Pages: XI, 337 p. 65 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031058431
    Series Statement: Advances in Experimental Medicine and Biology, 1383
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Bioenergetics. ; Biomedical engineering. ; Neurochemistry. ; Mental health. ; Neuroscience. ; Bioenergetics. ; Biomedical Engineering and Bioengineering. ; Neurochemistry. ; Mental Health.
    Description / Table of Contents: Aim of the book -- Basic principles and technology of nadh and multiparametric monitoring used in studying cortical spreading depression (csd) -- Single point and multisite monitoring of brain nadh fluorescence under csd -- Sequence of physiological responses recorded during induced csd event -- Spontaneous development of csd related to brain pathophysiological conditions -- The effects of brain metabolic and other perturbations on the responses to induced csd -- Effects of pharmacological agents on csd -- Clinical monitoring of csd in the human brain -- CSD and the lifenlight score (lls) -- Discussion and conclusions -- Index.
    Abstract: This book focuses on energy metabolism and brain functions related to Cortical Spreading Depression of Leao (CSD), an important issue in brain pathophysiology. The first part of the book offers a comprehensive overview of the history and early research on CSD, and then discusses the recent advances in the technology used to map and monitor brain mitochondrial NADH redox state and other physiological functions during CSD. The chapters explore the connection between CSD and mitochondrial function under hypoxia, Ischemia and various drugs treatment, and provide a resource to scientists researching the development of CSD during various brain pathophysiological conditions. This book is essential to scientists and students working in the field of bioenergetics of the brain and various organs and tissues in the body. The use of this technology is also crucial and applicable in the neuroscience field.
    Type of Medium: Online Resource
    Pages: XXI, 420 p. 242 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031080685
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Emotions. ; Neuropsychology. ; Neuroscience. ; Emotion. ; Neuropsychology.
    Description / Table of Contents: Part I. Basic Principles of Cerebellar Function in Emotion -- Chapter 1. Introduction into the Role of the Cerebellum in Emotion -- Chapter 2. Principles of Brain and Emotion: Beyond the Cortico-Centric Bias -- Chapter 3. Cerebellum and Emotion Processing -- Chapter 4. Cerebellum and Emotion Recognition -- Chapter 5. Cerebellum and Emotion Memory -- Part II. Cells and Molecules of Emotions in the Cerebellum -- Chapter 6. Topography of Emotions in Cerebellum as Appraised by Functional Imaging -- Chapter 7. The Neurophysiology of the Cerebellum in Emotion -- Chapter 8. Non-invasive Brain Stimulation of the Cerebellum in Emotion -- Part III. Cerebellum and Emotion in High Order Domains -- Chapter 9. Reward-Based Learning and Emotional Habit Formation in the Cerebellum -- Chapter 10. Cerebellar Contribution to Emotional Body Language Perception -- Chapter 11. Influence of Pain on Cognitive Dysfunction and Emotion Dysregulation in Chiari Malformation Type I -- Chapter 12. Cerebellum and Emotion in Morality -- Chapter 13. Music and the Cerebellum -- Chapter 14. The Cerebellum and Beauty: The Impact of the Cerebellum in Art Experience and Creativity -- Chapter 15. Cerebellum and Emotion in Social Behavior -- Chapter 16. Cerebellum, Embodied Emotions, and Psychological Traits -- Part IV. Cerebellum and Emotion Disorders -- Chapter 17. The Cerebellum and Disorders of Emotion -- Chapter 18. Cerebellum and Neurorehabilitation in Emotion with a Focus on Neuromodulation -- Part V. Perspectives -- Chapter 19. Current and Future Perspectives of the Cerebellum in Affective Neurosciences.
    Abstract: Emotions represent a critical aspect of daily life in humans. Our understanding of the mechanisms of regulation of emotions has increased exponentially these last two decades. This book evaluates the contribution of the cerebellum to emotion. It outlines the current clinical, imaging and neurophysiological findings on the role of the cerebellum in key aspects of emotional processing and its influence on motor and cognitive function and social behavior. In the first section, the reader is introduced to the contributions of the cerebellum to various emotion domains, from emotion perception and recognition to transmission and encoding. Subsequent chapters provide a comprehensive picture of the neurophysiology and topography of emotion in the cerebellum and illustrate the convergence of theoretical and empirical research. Additional chapters address the cerebellum's involvement in emotional learning, emotional pain, emotional aspects of body language and perception, and its relations to social cognition including morality, music, and art. Finally, neuropsychiatric aspects of the cerebellum's influence on mood disorders and the current state of therapeutic options, including noninvasive stimulation approaches, complete the overview. This is the first book summarizing the current state of knowledge on the contribution of the cerebellum to important aspects of emotion. It is an essential reference for students, trainees, neuroscientists, researchers, and clinicians in neuroscience, neurology, neurosurgery and psychology involved in the study of emotions. The authors are renowned scientists in the field of cerebellar research.
    Type of Medium: Online Resource
    Pages: XII, 313 p. 42 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030995508
    Series Statement: Advances in Experimental Medicine and Biology, 1378
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Computational neuroscience. ; Computer science. ; Artificial intelligence. ; Data structures (Computer science). ; Information theory. ; Computational Neuroscience. ; Computer Science. ; Artificial Intelligence. ; Data Structures and Information Theory.
    Description / Table of Contents: Part 1: Basic Facts and Ideas for a Brain -- Chapter 1: The brain is an organ for information processing -- Chapter 2: The organization and improvement of behavior.-Chapter 3: A neuronal realization of the survival algorithm -- Chapter4: On the structure and function of cortical areas -- Part 2: Thinking in Cell Assemblies -- Chapter 5: Cognitive mental processes realized by cell assemblies in the cortex -- Chapter 6: A Model of Language Understanding by Interacting Cortical Areas -- Chapter 7: Can we accept a mechanistic description of our mental processes? -- Part 3: Further Developments until Today -- Chapter 8: Developments in Computer Science and Technical Applications -- Chapter 9: New Results from Brain Research and Neuroscience -- Chapter 10: Development of Brain Theory -- Chapter 11: Do we need Cognitive Neuroscience?. .
    Abstract: In the new edition of Neural Assemblies, the author places his original ideas and motivations within the framework of modern and cognitive neuroscience and gives a short and focused overview of the development of computational neuroscience and artificial neural networks over the last 40 years. In this book the author develops a theory of how the human brain might function. Starting with a motivational introduction to the brain as an organ of information processing, he presents a computational perspective on the basic concepts and ideas of neuroscience research on the underlying principles of brain function. In addition, the reader is introduced to the most important methods from computer science and mathematical modeling that are required for a computational understanding of information processing in the brain. Written by an expert in the field of neural information processing, this book offers a personal historical view of the development of artificial intelligence, artificial neural networks, and computational cognitive neuroscience over the last 40 years, with a focus on the realization of higher cognitive functions rather than more peripheral sensory or motor organization. The book is therefore aimed at students and researchers who want to understand how the basic neuroscientific and computational concepts in the study of brain function have changed over the last decades.
    Type of Medium: Online Resource
    Pages: XXI, 259 p. 87 illus., 10 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783031003110
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Cognitive psychology. ; Art Philosophy. ; Neuropsychology. ; Philosophy of mind. ; Neuroscience. ; Cognitive Psychology. ; Philosophy of Art. ; Neuropsychology. ; Philosophy of Mind.
    Description / Table of Contents: Introduction on THINKING: Bioengineering of Science and Art -- Thinking as A Philosophical, Theological and Psychological Phenomenon -- How to Think about Human-Animal Differences in Thinking: Two Cases of Marginal Analogy in the Philosophical Explication of Animal Cognition -- Homo Pictor’: A Philosophical Enquiry into the Origins of Human Thinking -- Idealism and Science of Life: An Intersection between Philosophy and Biology -- Embodied Creativity and Symbolic Variation in The Evolution of Life -- Within the Box: Captives of our Own Mind -- The Dialectic of Mind and Matter in The Trialectic Approach: A New Path of The Cognition Process -- Efforts Deployed in the Penetration of “Thought” -- Pseudo-Thinking and Real Thinking -- Three Paradoxes of Thought: Thought Power Measured -- A New Philosophical Paradigm of Thinking for Particular Sciences: Physics, Cognitive Science, and Biology -- Indicators of Variation in Thinking Actions and Reactions -- Multidimensional Thinking: Economizing Thinking and Maximizing Outcomes -- How You Know What I Know That She Said About You: Theory of Mind, Intentionality and the Evolutionary Roots of Artistic Practice -- A Philosophical Perspective on the Bioengineering of Art: Ethical Shifts in Mimesis -- Thinking Through the Body: Art and Philosophy in Dialogue -- Mechanism vs. Organism: A Loosely Kantian Perspective and its Implications for Bioengineering -- New Media Art: The Liminal Space Between Thinking and Perceiving -- Towards a New Science of Interfaces: Bridging Art and Engineering -- Art as Metacognitive Tool for Critical Thinking in Engineering -- Dimensions of Thinking, Reflecting, and Knowing through Design -- Thinking Through Sound: Music Listening as A Model for Enhanced Cognition -- Poetic Thinking and the Constitution of Our World: On Language and Reality -- Thinking as the Invention of New Aspects within Language-Games -- Literature as a Genealogy of the Social Sciences Thought -- How Rational Thought Is Conceived in Christian Doctrine: The Case of Saint Thomas Aquinas -- The Interest of Religion on Ethical Thought in Science -- Thinking, Politics, and the Evolutionary Process of Societies -- Information Processing in Reasoning in the Environment of Forbidden Sentences -- The impact of economic science on human thinking -- Generations of Systems Thinking: Models for Future Learning -- Systems Thinking and Action for An Entrepreneurial Journey Towards the House of Lab Science -- Systems Approach for Modeling Multifactorial Human Interactions that Affect Ecological and Environmental Systems -- Cradle to Cradle and Cradle to Grave: Discussing the Case of Eco-Coffins -- THINKING 2050: Bioengineering of Science and Art.
    Abstract: The “THINKING: Bioengineering of Science and Art” is to discuss about philosophical aspects of thinking at the context of Science and Art. External representations provide evidence that the fundamental process of thinking exists in both animal subjects and humans. However, the diversity and complexity of thinking in humans is astonishing because humans have been permitted to integrate scientific accounts into their accounts and create excellent illustrations for the effects of this integration. The book necessarily begins with the origins of human thinking and human thinking into self and others, body, and life. Multiple factors tend to modify the pattern of thinking. They all will come into play by this book that brings thinking into different disciplines: humanities, natural sciences, social sciences, formal sciences, and applied sciences. The thinking demands full processing of information, and therefore, the book considers the economy of thinking as well. The book thoroughly intends to explore thinking beyond the boundaries. Specifically, several chapters are devoted to discipline this exploration either by artistic thinking alone or by art and mathematics-aided engineering of complexities. In this manner, the book models variations on thinking at the individual and systems levels and accumulates a list of solutions, each good for specific scenarios and maximal outcomes. .
    Type of Medium: Online Resource
    Pages: XVI, 803 p. 206 illus., 131 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040757
    Series Statement: Integrated Science, 7
    DDC: 612.8
    Language: English
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    Keywords: Psychobiology. ; Human behavior. ; Cognitive neuroscience. ; Psychiatry. ; Behavioral Neuroscience. ; Cognitive Neuroscience. ; Psychiatry.
    Description / Table of Contents: Discovery science chapters -- Effects of AEDs on behaviour -- How to separate effects of seizures when studying behaviour -- Depression-like behaviour in epilepsy models -- Are behavioural deficits core components of epilepsy? -- Does stress trigger seizures: evidence from animal models? -- Early life stress and epilepsy -- disease models and epilepsy -- Disease modification in epilepsy: behavioural accompaniments -- Clinical chapters -- Do psychotropic drugs cause epileptic seizures? A review of the available evidence. Peri-ictal and para-ictal psychiatric phenomena: a relatively common yet unrecognized disorder -- Can we anticipate and prevent the occurrence of iatrogenic psychiatric events caused by antiepileptic drugs and epilepsy surgery? -- Are psychiatric disorders a risk for the development of treatment-resistant epilepsy? Temporal lobectomy: does it worsen or improve presurgical psychiatric disorders? -- Suicidality in epilepsy: does it share common pathogenic mechanisms with epilepsy? -- Psychotic disorders in epilepsy: do they differ from primary psychosis? -- Do neurobiologic aspects of primary psychiatric disorders account for the relatively high prevalence of psychiatric comorbidities in epilepsy? -- Are psychogenic non-epileptic seizures really the expression of a psychogenic process?
    Abstract: Many people living with epilepsy also suffer from debilitating psychiatric and cognitive disorders. While these comorbidities have been recognized for centuries, their causation, and relationship to the epilepsy remains clouded in mystery. This volume highlights recent knowledge and findings as well as controversies in our current understanding of behavioral and psychiatric comorbidities of epilepsy.
    Type of Medium: Online Resource
    Pages: X, 351 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031032356
    Series Statement: Current Topics in Behavioral Neurosciences, 55
    DDC: 612.8
    Language: English
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  • 49
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Psychobiology. ; Human behavior. ; Sex. ; Behavioral Neuroscience. ; Gender Studies.
    Description / Table of Contents: 1-Measuring Sex Differences and Similarities -- 2-Prenatal Steroid Hormones and Sex Differences in Juvenile Rhesus Macaque Behavior -- 3-Biological Approaches to Studying Gender Development -- 4-Social Influences on Gender Development: Theory and Context -- 5-Contemporary Cognitive Approaches to Gender Development: New Schemas, New Directions, and New Conceptualizations of Gender -- 6-Origins and Consequences of Childhood Gender Segregation: Towards an Integrative Developmental Systems Model -- 7-Gender, Toys, and Play: How Gendered Early Experiences Shape Later Development -- 8-Family Gender Socialization in Childhood and Adolescence -- 9-Gender Stereotypes and Education -- 10-Gender-Based Discrimination in Childhood and Adolescence -- 11-Gender and Sexuality in Disorders/Differences of Sex Development -- 12-Sexuality Development in Childhood -- 13-Sexual Pleasure in Adolescence: A Developmental Sexual Embodiment Perspective -- 14-Pornography Use in Adolescence and Young Adulthood -- 15-A Review of Theoretical Models and Lifespan Approaches to the Study of Sexual Offending -- 16-Learned but Not Chosen: A Reward Competition Feedback Model for the Origins of Sexual Preferences and Orientations -- 17-Carving the Biodevelopment of Same-Sex Sexual Orientation at Its Joints -- 18-Mental Health Among LGBT Youth -- 19-Asexuality: When Sexual Attraction is Lacking -- 20-Erotic Target Identity Inversions -- 21-Consensual Non-monogamy from a Developmental Perspective.
    Abstract: This book showcases a wealth of knowledge and insight on gender and sexuality development. With contributions from leading researchers, it covers a comprehensive set of topics at the forefront of the field and strikes a balance between traditional and emerging areas of study. Given that gender and sexuality are shaped by myriad influences, this book is modelled on an interdisciplinary perspective and delves into biological, comparative, psychological, cognitive, social, cultural, and clinical approaches. In so doing, this collection conveys the rich tapestry of gender and sexuality science and will hold value for many. For those already in the field, this book provides an excellent resource for brushing up on the latest and for inspiring the next phases of scientific investigation. Those who are newer to the field, including undergraduate and graduate students, stand to gain tremendously from not only the thoughtful and informative content, but also from the interdisciplinary approach modelled throughout the book. Beyond academia, this book is a valuable resource for clinicians and policy makers who deal with child and adolescent issues.
    Type of Medium: Online Resource
    Pages: XXIII, 636 p. 21 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030842734
    Series Statement: Focus on Sexuality Research,
    DDC: 612.8
    Language: English
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  • 50
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Biomedical engineering. ; Materials Analysis. ; Imaging systems. ; Imaging systems in biology. ; Neuroscience. ; Biomedical Engineering and Bioengineering. ; Imaging Techniques. ; Biological Imaging.
    Description / Table of Contents: Chapter 1: Introduction -- Chapter 2: Neural Tissue and its Signals -- Chapter 3: Measurements -- Chapter 4: Source Models -- Chapter 5: Forward Models -- Chapter 6: Inverse Methods -- Chapter 7: Assessment -- Chapter 8: Applications.
    Abstract: This textbook provides a comprehensive and didactic introduction from the basics to the current state of the art in the field of EEG/MEG source reconstruction. Reconstructing the generators or sources of electroencephalographic and magnetoencephalographic (EEG/MEG) signals is an important problem in basic neuroscience as well as clinical research and practice. Over the past few decades, an entire theory, together with a whole collection of algorithms and techniques, has developed. In this textbook, the authors provide a unified perspective on a broad range of EEG/MEG source reconstruction methods, with particular emphasis on their respective assumptions about sources, data, head tissues, and sensor properties. An introductory chapter highlights the concept of brain imaging and the particular importance of the neuroelectromagnetic inverse problem. This is followed by an in-depth discussion of neural information processing and brain signal generation and an introduction to the practice of data acquisition. Next, the relevant mathematical models for the sources of EEG and MEG are discussed in detail, followed by the neuroelectromagnetic forward problem, that is, the prediction of EEG or MEG signals from those source models, using biophysical descriptions of the head tissues and the sensors. The main part of this textbook is dedicated to the source reconstruction methods. The authors present a theoretical framework of the neuroelectromagnetic inverse problem, centered on Bayes’ theorem, which then serves as the basis for a detailed description of a large variety of techniques, including dipole fit methods, distributed source reconstruction, spatial filters, and dynamic source reconstruction methods. The final two chapters address the important topic of assessment, including verification and validation of source reconstruction methods, and their actual application to real-world scientific and clinical questions. This book is intended as basic reading for anybody who is engaged with EEG/MEG source reconstruction, be it as a method developer or as a user, including advanced undergraduate students, PhD students, and postdocs in neuroscience, biomedical engineering, and related fields. .
    Type of Medium: Online Resource
    Pages: XIX, 415 p. 174 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030749187
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Pediatrics. ; Bioinformatics. ; Clinical health psychology. ; Critical psychology. ; Neuroscience. ; Pediatrics. ; Computational and Systems Biology. ; Health Psychology. ; Critical Psychology.
    Description / Table of Contents: Part 1: Mechanisms underlying brain changes during sensitive periods -- Development of functional properties in the early visual system: new appreciations of the roles of lateral geniculate nucleus -- Maturation of Corticolimbic Functional Connectivity during Sensitive Periods of Brain Development -- Microglia and sensitive periods in brain development -- Is Adolescence a Sensitive Period for the Development of Incentive Reward Motivation? Part 2: The influences of positive and negative factors during sensitive periods -- Physical Activity, Fitness and Executive Functions in Youth: Effects, Moderators and Mechanisms -- Nutrition and brain development.-Understanding sensitive period effects in musical training -- Sensitive periods for recovery from early brain injury -- Part 3: Community level impact of sensitive periods: analyses and applications -- Statistical Modeling of Sensitive Period Effects Using the Structured Life Course Modeling Approach (SLCMA) -- Capitalizing on neuroplasticity across development to redirect pathways from juvenile justice involvement.
    Abstract: Sensitive periods occur when unique experiences permanently influence brain development either by their presence or absence. This volume covers underlying brain systems and behaviors that are sculpted by the environment in humans and animals in a search for commonalities. The mechanisms involved, the importance of timing in the process, and factors that can change the brain are discussed in this exciting book. Different chapters examine how experience guides the development of cells, circuits, and function using vision, cortical circuits, and cognition as frameworks. Scientific evidence for effective preventative intervention approaches, including diet, exercise, and music, are included to find ways to maximize child and adolescent development. The adverse effects of early brain injury are also included. As sensitive periods are gaining importance in their application in the real-world, novel statistical approaches for human studies are presented and the importance of sensitive periods are covered by examining the juvenile justice system. The book has interdisciplinary appeal and scholars with an interest in brain resiliency or vulnerability will find it of particular interest.
    Type of Medium: Online Resource
    Pages: XII, 254 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031044731
    Series Statement: Current Topics in Behavioral Neurosciences, 53
    DDC: 612.8
    Language: English
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  • 52
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Nervous system Regeneration. ; Alternative medicine. ; Neurology . ; Regeneration and Repair in the Nervous System. ; Complementary and Alternative Medicine. ; Neurology.
    Description / Table of Contents: Histopathological Basis for Acupuncture -- Current Advances in Mathematical Models of Initial Response to Mechanical Stimulation at Acupoint -- Signal Transduction in Acupoints -- Cellular Mechanisms in Acupuncture Effects -- Chemical and Physical Characteristics of Moxibustion -- Imaging of Acupuncture’s Effects: From Bedside to Bench -- Meridians – Neurosensory Organs within the System of Homeostatic Regulation -- Meridian-Viscera Correlationship: Theory and Mechanism of the Heart Meridian-Heart-Brain Interactions -- Autonomic Function and Electroacupuncture -- Understanding of Myofasial Trigger Points: Acupuncture verses Dry Needling -- Current Research in Silver Needle Acupuncture for Myofascitis -- Acupuncture in Supportive Care for Breast Cancer Survivors -- Alternative Therapies for Chemotherapy-Induced Peripheral Neuropathy -- Acupuncture and Related Techniques for Perioperative Care of Surgical Patients -- Hypothalamic-pituitary-adrenal Axis: A Bridge between acupuncture and diseases -- Neurobiological Mechanism of Acupuncture Analgesia in Chronic Somatic Pain -- Analgesic Effects of Acupuncture on Orofacial Pain -- Itch and the Antipruritic Effect of Acupuncture -- Acupuncture for Autism Spectrum Disorders -- Acupuncture Treatment for Multiple Sclerosis -- The Clinical and Experimental Study on Acupuncture for Children with Cerebral Palsy -- Beneficial Effect of Acupuncture on Depressive Disorders -- Acupuncture and Alzheimer’s Disease -- Acupuncture Treatment for Alzheimer’s Disease -- Electroacupuncture against Ischemic Brain Injury: Efficacy, optimal conditions and Mechanisms.
    Abstract: Written by over seventy scientists and clinicians worldwide from China, USA, Germany, Canada, Japan and other countries, this monograph, with nearly 450 figures and tables, covers a wide range of advanced progress in acupuncture research, from experimental research to clinical applications. In addition to exploring the histopathological basis for acupuncture and mathematical simulation of acupoint response to stimulation, initiation and transduction of acupuncture signals and cellular mechanisms during acupuncture effects as well as chemical and physical characteristics of moxibustion on acupoints are broadly discussed. The topics also include novel data on acupuncture effect with advanced imaging techniques, a unique understanding of meridian-viscera correlation, specific interactions between meridians and neurosensory organs within the system of homeostatic regulation and the acupuncture-induced influences on autonomic function. Several chapters introduce specific approaches with dry needling, silver needling and stainless needling for certain diseases, such as myofascitis, supportive care for breast cancer and chemotherapy-induced peripheral neuropathy as well as perioperative care of surgical patients. Moreover, this book discusses recent research on acupuncture therapy and potential mechanisms for a number of severe and refractory neurological disorders, including hyperactivity of hypothalamic-pituitary-adrenal axis, orofacial pain, chronic pain, itch, multiple sclerosis, autism spectrum disorders, cerebral palsy, depressive disorders, Alzheimer’s disease and ischemic brain injury. The vast amount of information offered in this book provides a comprehensive perspective on advanced acupuncture research to not only acupuncturists, but also to neuroscientists, neurologists, and other clinicians. For medical students and graduate and undergraduate students majoring in biology, physiology and neuroscience, this book offers an advanced course in learning about the mechanism-driven advances in alternative and complementary medicine. * Contains a comprehensive summary of the latest advances in acupuncture research from all over the world * Provides an easy-to-navigate reference for acupuncture researchers and neuroscientists alike * Combines basic and clinical knowledge of acupuncture and explores the molecular and neurobiological mechanisms that underlie it.
    Type of Medium: Online Resource
    Pages: XXIX, 750 p. 423 illus., 362 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030962210
    DDC: 612.8
    Language: English
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  • 53
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Evolution (Biology). ; Psychology. ; Neuroscience. ; Evolutionary Biology. ; Behavioral Sciences and Psychology.
    Description / Table of Contents: Chapter. 1. Introduction -- Chapter. 2. Eusociality -- Chapter. 3. Brain and social environment -- Chapter. 4. Socio-biological interactions -- Chapter. 5. Social Inequality -- Chapter. 6. Culture and evolution -- Chapter. 7. Means of social coercion -- Chapter. 8. Population growth and the collective brain -- Chapter. 9. Tooling and technology -- Chapter. 10. The Homo sapiens, evolution of the warmonger human -- Chapter. 11. Factors of our human future -- Chapter. 12. On the human dimension -- Chapter. 13. Our species’ hypothetical alternatives.
    Abstract: This book approaches two behavioral domains involved with human nature and actions related to dominance, an ancient animal, survival-linked, behavioral drive anchored in basal neural brain circuits. These domains result in latent or manifest conflicts among components of human animal nature and cultural profiles. The first domain refers to evolutive animal behavioral inertias that affect the basic construction of our brain/mind and social behavioral spectrum, underneath cultural and political enclosures. The second domain is considered a consequence of the previous one and involves the concept that the basic animal behavioral drive of dominance interferes with the expression of a truly human, cooperative social construction, and fosters conflicts (based on profit or comparative advantage). This drive tints or conditions our behavior in all its expressions (parochial, social, political, financial, religious, cognitive development). It also fosters social detachment of elite minorities –financially powerful and drivers of human evolutionary trends– from general concerns and collective needs of legions of subdued populations. Additionally, the latter promotes Star Wars factual chimeras and expanding dominance/prevalence and power grip beyond earthbound objectives that promote spatial exploration and scientific objectives. The quest for knowledge is embedded in our behavioral construction but employed by opportunistic – political – strategies that seek dominance/prevalence. Basic, ancestral, animal drives, here focused on dominance, lie underneath our sociocultural expressions, and feed construction of survival, ideology, class prejudices, submissiveness, cooperativity, and technological development. On top of this basic drive, humans have construed additional relational levels (whether of cognitive or emotional nature) expressed as cultural constructions that provide means to attempt to approach a socially acceptable format and public support. Whenever these processes collide or collapse, individual and collective standings tend to generate social changes or individual or collective pathologies. This book should be an exciting read for all those enthusiasts of the human mind, behavior, and cultural evolution ranging from fields such as neuroscience and biology to political sciences and anthropology. Given the breadth of studies as well as the clear language used by the author, students will find this book as a resourceful material for the undergraduate and graduate studies.
    Type of Medium: Online Resource
    Pages: XIII, 155 p. 15 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030974015
    DDC: 612.8
    Language: English
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  • 54
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Using electrical stimulation to explore and augment the functions of parietal-frontal cortical networks in primates -- 2. Multi-system benefits of epidural stimulation following spinal cord injury. 3. Neurostimulator for hippocampal memory prosthesis -- 4. Modern approaches to augmenting the brain functions -- 5. Brain machine interfaces within a critical perspective -- 6. An implantable wireless device for ECoG and cortical stimulation -- 7. BCI Performance improvement by special low jitter quasi-steady State VEP paradigm -- 8. Communication with Brain-Computer Interfaces in Medical Decision-Making -- 9. Neuroprotection and neurocognitive augmentation by photobiomodulation -- 10. Avoiding partial sleep - the way for augmentation of brain function -- 11. Augmentation of brain functions by nanotechnology -- 12. The impact of ageing and age-related comorbidities on stroke outcome in animal models and humans -- 13. Diagnostic markers of sub-clinical depression based on functional connectivity -- 14. Transcranial magnetic stimulation in autism spectrum disorders: modulating brainwave abnormalities and behaviors -- 15. Neurofeedback training with concurrent psychophysiological monitoring in children with autism spectrum disorder with comorbid attention deficit/hyperactivity disorder -- 16. Augmentation through interconnection: brain-nets and telemedicine -- 17. Cognitive augmentation via a brain/cloud interface -- 18. Augmentation of neuro-marketing by neural technology -- 19. Augmentation of nutrition by nanotechnology -- 20. Neural spintronics: noninvasive augmentation of brain functions -- 21. Does the power to suppress an action make us free? -- 22. Deep brain stimulation for Parkinson’s disease-future directions for enhancing motor function -- 23. Neuromodulation for gait -- 24. Augmentation and rehabilitation with active orthotic devices -- 25. Effects of rTMS on behavioral and electrocortical measures of error monitoring and correction function in children with autism spectrum disorder -- 26. Affective Virtual Reality Gaming for Autism -- 27. A machine learning approach to automatic phobia therapy with virtual reality -- 28. Vision augmentation by pharmacological enhancement of the visual experience -- 29. Cognitive enhancing substances and the developing brain: risks and benefits -- 30. Pharmacological approaches in the augmentation and recovery of brain function.
    Abstract: This book covers recent advances in the neural technology that produces enhancements for brain function. It addresses a broad range of neural phenomena occurring in the brain circuits for perception, cognition, emotion and action, representing the building blocks of the behavior and mind. Augmentation of brain function is achieved using brain implants for recordings, stimulation and drug delivery. Alternative methods include employing brain-machine interfaces, as well as noninvasive activation of certain brain areas. Existing methods of brain augmentation are evaluated, and new approaches are introduced. Brain circuitry and neuronal mechanisms that are candidates for augmentation are discussed. This volume provides novel insights into brain disorders, and new devices for brain repair. Information in this book is relevant to researchers in the field of neuroscience, engineering, and clinical practice. Philosophical and ethical implications of brain augmentation are also addressed. “This impressive book by leading experts in neuroscience and neuroengineering lays out the future of brain augmentation, in which the human mind and machine merge, leading to a rapid exponential growth of the power of humanity.” – Ray Kurzweil "This book employs a holistic approach in covering the recent advances in the fields of neuroscience, neuroinformatics, neurotechnology and neuro-psycho-pharmacology. Each chapter of the book covers major aspects of modern brain research in connection with the human mind and behavior, and is authored by researchers with unique expertise in their field. " – Ioan Dumitrache “This book presents compelling perspectives on what interactive neuroscience will look like in the future, delving into the innovatory ideas of a diverse set of neuroscientists, and speculating on the different ways computer chips implanted in the brains of humans can effect intelligence and communication.” – György Buzsáki.
    Type of Medium: Online Resource
    Pages: XXII, 747 p. 189 illus., 153 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030545642
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 55
    Keywords: Neurosciences. ; Neurology . ; Medical genetics. ; Neuroscience. ; Neurology. ; Medical Genetics.
    Description / Table of Contents: 1. Behavioural variant FTD: recent advances in the diagnosis and understanding of the disorder -- 2. The neuropsychiatry of frontotemporal dementia -- 3. Nosology and Neuropathology of Language in Primary Progressive Aphasia -- 4. Measuring Behavior and Cognition in FTLD -- 5. Clinical update on C9orf72: FTD, ALS and beyond -- 6. Clinical aspects of familial FTLD associated with MAPT and GRN mutations -- 7. Neuroimaging in Frontotemporal Lobar Degeneration -- 8. The FTD Prevention Initiative - linking together genetic FTD cohort studies -- 9. Fluid Biomarkers of Frontotemporal Lobar Degeneration -- 10. Cross-cultural perspectives on frontotemporal degeneration -- 11. Clinical characteristics and Neuropathology of PSP, CBD and Related 4R-Tauopathies -- 12. Tau protein and frontotemporal dementias -- 13. FTLD-TDP pathological subtypes: clinical and mechanistic significance -- 14. Lysosomal dysfunction as a pathogenic mechanism in FTD: Evidence from PGRN and TMEM106B genetics and biology -- 15. Future trends in understanding the pathological role of TDP-43 and FUS proteins -- 16. Description of a new data resource for FTD including multiomic data on human post mortem brain (MAPT, GRN, C9orf72), matching mouse models and iPS models -- 17. Mendelian and sporadic FTD: avenues from genetics to disease pathways through in-silico prediction and modeling -- 18. FTLD treatment: Current Practice and Future Possibilities.
    Abstract: Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.
    Type of Medium: Online Resource
    Pages: X, 320 p. 46 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030511401
    Series Statement: Advances in Experimental Medicine and Biology, 1281
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Nervous system Diseases. ; Neurology . ; Neurophysiology. ; Neuropsychology. ; Neurons. ; Neuroscience. ; Neurological Disorders. ; Neurology. ; Neurophysiology. ; Neuropsychology. ; Cellular Neuroscience.
    Description / Table of Contents: Introduction: Neuroglia in psychiatric disorders -- Chapter 1. Astrocytes: The housekeepers and guardians of the CNS -- Chapter 2. Principles of astrogliopathology -- Chapter 3. Morphological appearance of astroglia in neuropsychiatric disorders -- Chapter 4. Astrocytes and neurotransmission: Glutamate and GABA in cognitive and mood disorders -- Chapter 5. Astroglia in bipolar disorder -- Chapter 6. Astroglia abnormalities in mood disorders -- Chapter 7. Astroglia in major depression and suicide -- Chapter 8. Neuroglia in Schizophrenia -- Chapter 9. Glutamate turnover in Schizophrenia -- Chapter 10. Astroglia and dopanime transmission in Schizophrenia -- Chapter 11. Kynurenic acid in Schyzophrenia -- Chapter 12. Astrocytes in addictive disorders -- Chapter 13. Astroglia in the vulnerability and maintenance of alcohol dependence -- Chapter 14. Astroglia in response to stress -- Chapter 15. Astroglia and Obsessive compulsive disorder -- Chapter 16. Astrocytes in regulation of food intake -- Chapter 17. Astrocytes in anorexia nervosa -- Chapter 18. Astroglial serotonin receptors as the central target of classic antidepressants -- Chapter 19. Lithium targets astrocytes -- Epilogue.
    Abstract: This contributed volume discusses the multiple roles of astrocytes, which determine the progression and outcome of neuropsychiatric diseases. This emerging area of study examines the ways in which astrocytes are involved in various aspects of disease initiation, progression and resolution. This monograph aims to integrate the body of information that has accumulated in recent years revealing the active role of astrocytes in neuropsychiatric pathology and in psychiatric disorders. Understanding roles of astrocytes in pathology will provide new targets for medical intervention and aid the development of much needed therapeutics. This book will be valuable for researchers and workers in the fields of neurobiology, neurology, and psychiatry, as well as fill the need for a textbook used in advanced courses/graduate seminars in glial pathophysiology.
    Type of Medium: Online Resource
    Pages: VI, 377 p. 36 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030773755
    Series Statement: Advances in Neurobiology, 26
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Anatomy. ; Internal medicine. ; Neuroscience. ; Anatomy. ; Internal Medicine.
    Description / Table of Contents: PART I. Glial-Neuronal Interactions in the Control of Hypothalamic Development -- The Role of Microglia in the Developing Hypothalamus -- PART II. Glial-Neuronal Interactions in the Control of the Magnocellular Neuroendocrine System -- Functional Consequences of Morphological Plasticity in the Adult Hypothalamo-Neurohypophysial System -- Fenestrated Capillary and Dynamic Neuro-Glial-Vascula Reorganization of the Adult Neurohypophysis -- Astrocyte-Magnocellular Neuron Interactions in Hypothalamic Memory -- The Multifaceted Roles of Hypothalamic Astrocytes and Microglial Cells in Neuroendocrine and Autonomic Regulation in Health and Disease -- PART III. Gial-Neuronal Interactions in the Control of Metabolic Function -- Control of Systemic Metabolism by Astrocytes in the Brain -- Glia-Neuron Communication: Not a One-way Street -- PART IV. Glial-Neuronal Interactions in the Control of the Stress Response -- Retrograde Signaling Via Dendritic Activation of Glial-Neuronal Circuits -- PART V. Glial-Neuronal Interactions in the Control of Reproductive Function -- Microglia, Hormones, and Behavior -- Hypothalamic Astrocytes and the Role of Neuroprogesterone in Estrogen Positive Feedback -- PART VI. Glial-Neuronal Interactions that Link Brain and Periphery -- Unveiling the Importance of Tanycytes in the Control of the Dialogue Between the Brain and the Periphery -- Tanycyte Regulation of Hypophysiotropic TRH Neurons.
    Abstract: This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 324 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030623838
    Series Statement: Masterclass in Neuroendocrinology, 11
    DDC: 612.8
    Language: English
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    Keywords: Computational neuroscience. ; Biomedical engineering. ; Neurology . ; Neurophysiology. ; Neuroanatomy. ; Image processing. ; Computational Neuroscience. ; Biomedical Engineering and Bioengineering. ; Neurology. ; Neurophysiology. ; Nervous System. ; Image Processing.
    Description / Table of Contents: 1. Physiology of Brain-Heart Interplay -- 2. Brain and Heart Signal Processing Methodology -- 3. Quantification of Functional Brain-Heart Interplay -- 4. Exemplary Applications to Real Brain and Heartbeat Data -- 5. Future Direction of Research and Prospective Applications using Functional Brain-Heart Interplay Assessment.
    Abstract: This monograph offers a cross-system exchange and cross-modality investigation into brain-heart interplay. Brain-Heart Interplay (BHI) is a highly interdisciplinary scientific topic, which spreads from the physiology of the Central/Autonomous Nervous Systems, especially Central Autonomic Network, to advanced signal processing and modeling for its activity quantification. Motivated by clinical evidence and supported by recent findings in neurophysiology, this monograph first explores the definition of basic Brain-Heart Interplay quantifiers, and then moves onto advanced methods for the assessment of health and disease states. Non-invasive use of brain monitoring techniques, including electroencephalogram and function Magnetic Resonance Imaging, will be described together with heartbeat dynamics monitoring through pulseoximeter and ECG signals. The audience of this book comprises especially of biomedical engineers and medical doctors with expertise in statistics and/or signal processing. Researchers in the fields of cardiology, neurology, psychiatry, and neuroscience in general may be interested as well.
    Type of Medium: Online Resource
    Pages: X, 236 p. 109 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030799342
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Neuro-Behçet’s Disease: Epidemiology and Genetics -- 2. Immunology of Neuro-Behçet’s Disease -- 3. Autoantibodies in Neuro-Behçet Disease -- 4. Animal Models of Behçet’s Disease -- 5. Pathology of Neuro-Behçets Disease -- 6. Behçet’s Disease: Clinical Features -- 7. Neuro-Behçet Syndrome: Differential Diagnosis -- 8. Neuro-Behçet Syndrome: Clinical Features -- 9. The Cerebrospinal Fluid Presentations of Neuro-Behçet Disease -- 10. Imaging of Neuro-Behçet’s Disease -- 11. Neuropsychiatric Symptoms In Neuro-Behçet’s Disease -- 12. Treatment of Neuro-Behçet’s Disease -- 13. Prognosis of Behçet’s Syndrome.
    Abstract: This contributed volume provides a complete overview of Neuro-Behçet’s disease (NBD), one of the most serious manifestations of Behçet’s disease. It serves as a comprehensive and critical review of the current scientific literature regarding NBD, covering the epidemiology, pathology, prognosis, and treatment of the disease. This book is an essential resource for both researchers and physicians working on neurology, rheumatology, and internal medicine fields.
    Type of Medium: Online Resource
    Pages: VIII, 172 p. 26 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030552732
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Abstract: Based on the 75th Fujihara Seminar held in December 2018 in Tokyo, Japan, this volume explores the latest research on the cerebellum. Contributors seek to examine the cerebellum's role as a unique hub for brain activity and discover new information about its purpose. The discussion is broad, ranging from evolutionary topics to therapeutic strategy and addresses both physiology and pathology. Subjects covered include anatomy, information processing, complex spikes, plasticity, modeling, and spinocerebellar ataxias. The volume is intended to set the stage for the future of cerebellar research and guide both basic and clinical researchers.
    Type of Medium: Online Resource
    Pages: XI, 553 p. 136 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030758172
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Human physiology. ; Neuroscience. ; Human Physiology.
    Description / Table of Contents: Gene structure, expression, and 5-HT2B receptor signaling.-Serotonin function during embryonic development: the 5-HT2B receptor contribution -- Stem cells to decipher the physiological roles of 5-HT2B receptor signaling.-The serotonergic system in hematopoiesis and hematopoietic disorders -- The 5-HT2B receptor, the immune system and neuroinflammation.-5-HT2B Receptor on Macrophages: What for?.-Bone and 2B Serotonin receptor.-Roles of 5-HT2B receptor in pain -- 5-HT2B receptor, the heart and blood vessels.-5-HT2B receptor in Cardiopulmonary Disease -- Serotonin and cardiac Valves Degeneration in dog -- The discovery of 5-HT2B receptor pharmacology through the understanding of drug- induced valvulopathy -- Serotonin and fibrosis -- 5-HT2B receptors in liver -- Metabolic Regulation: Insulin secretion and action -- Drugs of abuse affecting 5-HT2B receptors.-The Role of 5-HT2B receptor on Aggression and Drugs of Abuse -- Role of the serotonin 2B receptor in the reinforcing effects of psychostimulants -- Serotonin 2B receptor interactions with dopamine network: implications for therapeutics in schizophrenia -- A Role for the 5-HT2B receptor in the Neurobiology of Schizophrenia -- 5-HT2B receptors and antidepressants -- Serotonin and the 5-HT2B receptor in amyotrophic lateral sclerosis.
    Abstract: This contributed volume provides a comprehensive assessment of the roles played by 5-HT2B receptors in humans. These receptors have been shown to play an important role is the cardiac, intestinal, and central nervous systems as well as in bone marrow formation and growth. In this book, expert researchers present their findings on molecular and physiological/pathological aspects of 5-HT2B receptors. The molecular section includes a discussion of the genetics of 5-HT2B receptors and impulse control. The physiological section covers their role in many biological systems including the nervous system, the heart, and the lungs.
    Type of Medium: Online Resource
    Pages: VIII, 401 p. 44 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030559205
    Series Statement: The Receptors, 35
    DDC: 612.8
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Psychiatry. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: Preface -- The Neurobiology of Bipolar Disorder -- Pre-clinical studies and Animal Models -- Genetics in Bipolar -- Mitochondrial modulators for bipolar disorder: A paradigm for drug development -- Intracellular Signaling Cascades -- Circadian Rhythms and Sleep -- Neuroendocrine System in Bipolar -- Neuroanatomic and Functional Neuroimaging Findings -- Structural and Functional Aspects of Neuroprogression in BD -- Inflammation as a Mechanism of Neuroprogression -- Neurocognition in Bipolar -- The kindling/sensitization model and Early Life Stress -- Early Life Stress in Bipolar -- New pharmacological Interventions.
    Abstract: Bipolar disorder is a common, complex and costly mental health disorder, which sits at the heart of the practice of clinical psychiatry. Effective treatments (pharmacological, psychological and brain stimulation based) have all been discovered serendipitously. With the huge advances in basic neuroscience the way is now clear for novel treatments to be developed based on brain science. This book reviews these possibilities.
    Type of Medium: Online Resource
    Pages: VIII, 325 p. 23 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030721435
    Series Statement: Current Topics in Behavioral Neurosciences, 48
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Psychiatry. ; Neuroscience. ; Psychiatry.
    Description / Table of Contents: 1. Introduction -- 2. fMRI: Blood Oxygen Level Dependent Contrast and Its Value for Understanding Functioning Brain Networks -- 3. Review of Resting-State Functional Connectivity Methods and Application in Clinical Populations -- 4. Directed Interregional Brain Interactions -- 5. Meta-analytic connectivity modelling (MACM): A tool for assessing regionspecific functional connectivity patterns in task-constrained states -- 6. dMRI: Diffusion Magnetic Resonance Imaging as a Window onto Structural Brain Networks and White Matter Microstructure -- 7. Data Mining in the Era of Big Data: The BrainMap Database as a Resource for Characterizing Psychiatric Illness -- 8. Network modulation in neuropsychiatric disorders using The Virtual Brain -- 9. Networks-mediated spreading of pathology in neurodegenerative diseases -- 10. Resting-State Functional Network Disturbances in Schizophrenia -- 11. Disturbed Brain Networks in the Psychosis High-Risk State? -- 12. Functional Connectivity in Autism Spectrum Disorders: Challenges and Perspectives -- 13. Functional Resting-State Network Disturbances in Bipolar Disorder -- 14. An overview of resting state functional connectivity studies of major depressive disorder -- 15. Brain network dysfunction in bipolar disorder: evidence from structural and functional MRI studies -- 16. Understanding the Network Bases of ADHD: An Overview of the fMRI Evidence -- 17. Cortical-Limbic and Default Mode Networks in Borderline Personality Disorder -- 18. Structural and Functional Connectivity Changes Following Cognitive Remediation: A systematic review -- 19. Single-Subject Prediction: A Statistical Paradigm for Precision Psychiatry -- 20. Genetic Imaging: Promises and Pitfalls -- 21. Brain networks and the emergence of the Self: A neurophenomenal perspective -- 22. Research Domains and Brain Network Dysfunction: Toward a New Taxonomy of Neuropsychiatric Illness.
    Abstract: Brain network function and dysfunction is the dominant model for understanding how the brain gives rise to normal and abnormal behavior. Moreover, neuropsychiatric illnesses continue to resist attempts to reveal an understanding of their bases. Thus, this timely volume provides a synthesis of the uses of multiple analytic methods as they are applied to neuroimaging data, to seek understanding of the neurobiological bases of psychiatric illnesses, understanding that can subsequently aid in their management and treatment. A principle focus is on the analyses and application of methods to functional magnetic resonance imaging (fMRI) data. fMRI remains the most widely used neuroimaging technique for estimating brain network function, and several of the methods covered can estimate brain network dysfunction in resting and task-active states. Additional chapters provide details on how these methods are (and can be) applied in the understanding of several neuropsychiatric disorders, including schizophrenia, mood disorders, autism, borderline personality disorder, and attention deficit hyperactivity disorder (ADHD). A final complement of chapters provides a collective overview of how this framework continues to provoke theoretical advances in our conception of the brain in psychiatry. This unique volume is designed to be a comprehensive resource for imaging researchers interested in psychiatry, and for psychiatrists interested in advanced imaging applications.
    Type of Medium: Online Resource
    Pages: XVII, 488 p. 79 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030597979
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Physiology. ; Neurochemistry. ; Respiratory organs Diseases. ; Neuroscience. ; Physiology. ; Neurochemistry. ; Pneumology.
    Description / Table of Contents: Pulmonary sensory receptors -- The pulmonary NEB ME is a complex intraepithelial unit -- Studying the pulmonary NEB ME: a multidisciplinary approach -- Functional exploration of the pulmonary NEB ME -- Concluding remarks and future perspectives -- References -- ADDENDUM.
    Abstract: This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.
    Type of Medium: Online Resource
    Pages: XVIII, 95 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030658175
    Series Statement: Advances in Anatomy, Embryology and Cell Biology, 233
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuropsychology. ; Neural circuitry. ; Nervous system Diseases. ; Neuroscience. ; Neuropsychology. ; Neural Circuits. ; Neurological Disorders.
    Description / Table of Contents: PART I. Molecular Gears of the Circadian Clock -- Introduction to the Clock System -- Circadian Clocks, Sleep, and Metabolism -- Linking Depression to Epigenetics: Role of the Circadian Clock -- PART II. Brain Regions Implicated in Circadian Rhythms -- The Brain's Reward System in Health and Disease -- Brain Clocks, Sleep and Mood -- Astrocyte Circadian Timekeeping in Brain Health and Neurodegeneration -- PART III. Clock and Mental Illness -- The Role of the Circadian System in Attention Deficit Hyperactivity Disorder -- How Psychoactive Drugs and the Circadian Clock Are Enlightening One Another -- Circadian Rhythms in Mood Disorders -- The Reciprocal Interaction Between Sleep and Alzheimer’s Disease.
    Abstract: In this book, leading experts in the field review how circadian rhythms impact the brain. An essential function of mammalian life is the exploitation of the regularities provided by the 24-hour cycle of day and night. The development and evolution of circadian clock mechanisms have allowed us to optimally adapt our behavior and physiology to the external world. Not surprisingly, a growing body of evidence links the disruption of circadian rhythms by genetic, lifestyle and environmental factors to illnesses of the brain. In the first section of the book, readers will learn about the molecular and anatomic architecture of circadian function in mammals. The ways in which environmental disruptions and misalignments can influence such mechanisms and therefore impair brain function and health status are also addressed. In the second part, the focus shifts to those brain regions responsible for brain function and the body-wide regulation of circadian function. Amongst others, special attention is paid to the role of astrocytes and the brain’s reward and hyprocretin / orexin systems. The book concludes with an extensive discussion on the consequences of circadian rhythm dysfunction. Several chapters present the latest findings on Attention Deficit Hyperactivity Disorder, schizophrenia, autism spectrum disorder, drug abuse and mood disorders. Written by auhorities in the field, the book provides a state-of-the-art review of the latest findings on circadian clocks in the brain and highlights their potentially far-reaching impacts on our health and well-being. As such, it is essential reading for all neuroscientists and clinicians seeking to understand the intricate connections between circadian rhythms and brain health and illness.
    Type of Medium: Online Resource
    Pages: XI, 188 p. 15 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030811471
    Series Statement: Advances in Experimental Medicine and Biology, 1344
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medical genetics. ; Bioinformatics. ; Neuroscience. ; Medical Genetics. ; Bioinformatics. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Attitudes and smoking prevalence among undergraduate students in central Greece -- 2-Care of patients with Alzheimer’s disease -- 3-Regulation of antioxidant enzymes levels in rat brain -- 4-NIRS-based assessment of cerebral oxygenation during high definition anodal transcranial direct current stimulation in patients with posttraumatic encephalopathy -- 5-Cerebral critical closing pressure at concomitant traumatic brain injury -- 6-The role of inflammatory biomarkers as a diagnostic tool for possible late-life cognitive decline and dementias -- 7-The Development of Antisense RNA Treatments using Engineered Protein Substrates -- 8-Biomarker-driven analysis using high-throughput approaches in neuroinflammation and neurodegenerative diseases -- 9-Sensitive and Stereo specific high-performance liquid chromatographic method for flurbiprofen in human plasma -- 10-Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study -- 11-Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological Voices in Parkinsonian Patients -- 12-Effects of an 8-Week Stress Management Program in Women with Breast Cancer: A Randomized Controlled Trial -- 13-The Rosenberg Self-Esteem Scale: Translation and Validation in the Greek Language in Adolescents -- 14-Stress system activation analysis in Greek female adolescents: a bioimpedance study -- 15-Kisspeptin and the genetic obesity interactome -- 16-The importance of diagnostic and prognostic biomarkers identification and classification towards understanding ALS pathogenesis -- 17-Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia -- 18-Ebola virus disease and current therapeutic strategies; A review -- 19-Hyperbaric Oxygen Therapy effect on “Kinesia Paradoxa” Brain Circuits -- 20-Early and Very Early GRIM19 and MCL1 Expression are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line -- 21-Phospholipid Fatty Acid Profile of Spirulina platensis -- 22-Chronic systemic inflammation measured by bioimpedance technology before and after sleeve gastrectomy: a feasibility study -- 23-Synthesis and Biological Evaluation Substituted Thiophene Derivatives -- 24-Force spectroscopy in mechanical protein domains unfolding -- 25-Investigating the genetic component of Parkinson’s Disease -- 26-Urticaria from the Neurodermatological Perspective: A Temporal Analysis of Urticaria and Cognition -- 27-Novel Low-Noise CMOS Bioamplifier for the Characterization of Neurodegenerative Diseases -- 28-The Kentucky Inventory of Mindfulness Skills in Greek Undergraduate and Postgraduate Students -- 29-Synthesis, in silico stuiesand biological evaluation of 1, 3 ,4 oxadiazino indole derivatives -- 30-Designing and screening of new schiff bases of indole derivatives for anti-bacterial activity by in-silico methods and docking studies -- 31-Use of vitamin D bolus in fortified juice for improving vitamin D status in children with Cerebral Palsy -- 32-Microbes and the games they play -- 33-Impurity Profiling and Identification of 2,6 diisopropylphenol by Raman spectroscopy -- 34-Cultural Accommodation of the Strengthening Families Program for Parents and Young Adolescents 10-14: Greek Phase I & II Study -- 35-The effect of nutrients on Alzheimer’s disease biomarkers: A metabolomic approach -- 36-The impact of exercising in the quality of life of people with Aementia-Alzheimer disease -- 37-Advanced Health Technologies and Nanotechnologies in Neurodegenerative Diseases -- 38-Phenotype and genotype study in a case of frontometaphyseal dysplasia 1 -- 39-Craniofacial and neurological phenotype in a case of oculodentodigital syndrome -- 40-Clinical and molecular study of common thrombophilia mutation prothrombin G20210A -- 41-Prenatal genetic testing for X-linked hypohidrotic ectodermal dysplasia -- 42-Preimplantation genetic testing for spastic paraplegia type 3 -- 43-Synthesis, anti-inflammatory activity and in-silico studies of some new 3-({P-DIMETHYLAMINO}BENZYLIDENE YDRAZINYLIDENE)-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES -- 44-Design, characterization and docking studies of some novel isatin derivatives for anticonvulsant and antidepressant activity -- 45-Skin mirrors Brain: A Chance for Alzheimer’s Disease Research -- 46-Mitochondrial homeostasis in neurodegeneration and ageing -- 47-The Alzheimer's Disease Chronicles: will evidence triumph over adversity? -- 48-Liposomes: Production Methods and Application in Alzheimer’s Disease -- 49-Developing Treatments for Alzheimer’s and Related Disorders with Precision Medicine: A Vision -- 50-Biomarkers and Precision Medicine in Alzheimer’s Disease -- 51-The role of microRNAs in thrombosis -- 52-Photo-oxygenation: an innovative new therapeutic approach against amyloidoses.
    Abstract: The 4th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The relation between genetics and its effect on several diseases are thoroughly examined in this volume. This volume focuses on the sessions from the conference on Genetics and Neurodegenerative Diseases.
    Type of Medium: Online Resource
    Pages: XV, 435 p. 133 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030787875
    Series Statement: Advances in Experimental Medicine and Biology, 1339
    DDC: 612.8
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Psychiatry. ; Psychology. ; Neuroscience. ; Psychiatry. ; Behavioral Sciences and Psychology.
    Description / Table of Contents: The future of OC spectrum disorders, a research perspective -- Developmental Aspects of OCD -- Animal Models of OCD -- Inflammation, OCD and related disorders -- Genetic of OCD and related disorders -- Neurocognitive endophenotypes and OCD -- Structural Imaging and OCD -- Functional imaging and OCD -- Advances in PET and MRS imaging and OCD -- Goal directed deficit versus habit dominance in OCD -- Electrophysiology, Error processing and OCD -- Future Use of Exposure and response prevention in the Understanding and Treatment of OCD -- Pharmacogenetics and OCD -- Invasive And Non-Invasive Neurostimulation for OCD .
    Abstract: The book highlights important new research approaches of clinical relevance, written by prominent researchers in the field of OCD and related disorders. A broad range of topics is covered, beginning with a description of the phenotypic features of the OCD followed by chapters on developmental aspects, animal models, genetic and biological models including neuro-inflammation, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered including clinical and pharmacogenetic treatment models. In this way the volume brings together the key disciplines involved in the neurobiological understanding of OCD to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators and clinicians interested in the present state of OCD research.
    Type of Medium: Online Resource
    Pages: XII, 477 p. 70 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030753931
    Series Statement: Current Topics in Behavioral Neurosciences, 49
    DDC: 612.8
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Pharmacology. ; Neuroscience. ; Pharmacology.
    Description / Table of Contents: 1. Ayahuasca as an Unusually Versatile Therapeutic Agent: From Molecules to Meta-cognition and Back -- 2. New Evidence of the Antidepressant Effects of Ayahuasca -- 3. Psychedelic Medicines and Their Role in Shifting the Paradigm from Pharmacological Substitution Towards Transformation-Based Psychiatry -- 4. Ayahuasca and its Potential Role in Psychotherapy -- 5. A Qualitative Assessment of Risks and Benefits of Ayahuasca for Trauma Survivors -- 6. Ayahuasca and Childhood Trauma: Potential Therapeutic Applications and Risks -- 7. Ayahuasca and Cognition -- 8. Healing with the Brew: Ayahuasca’s Reconfiguration of “Addiction” -- 9. Ayahuasca Ritual Healing as an Addiction Treatment in Catalonia: Combining Cognitive and Cultural Perspectives -- 10. Perspectives on Healing and Recovery from Addiction with Ayahuasca-Assisted Therapy Among Members of an Indigenous Community in Canada -- 11. Ayahuasca as a Healing Tool Along the Continuum of Recovery from Eating Disorders -- 12. The Therapeutic Use of Ayahuasca in Grief -- 13.Depression, Anxiety and Sorcery: An Interview with Shipibo Healer Jose Lopez.
    Abstract: This book offers a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various disorders. This book presents biomedical and anthropological data on the use of ayahuasca and provides critiques on how it is used for treating depression, PTSD, anxiety, substance dependence, and eating disorders. The volume also explores ayahuasca’s role in the psychological well-being and quality of life of humans, and discusses possibilities of it enhancing cognition and coping with grief. The book examines ayahuasca’s association with psychotherapy and also highlights the challenges of integrating plant medicines into psychiatry. Further, the book expands on some preliminary research with animals, suggesting that ayahuasca acts at multiple levels of neural complexity. The study on the neurogenic effects of ayahuasca alkaloids opens a new avenue of research with potential applications ranging from psychiatric disorders to brain damage and dementia. Psychologists, psychiatrists, and other mental health professionals will find this book relevant to their work regarding substance abuse and alternative medicine.
    Type of Medium: Online Resource
    Pages: XXV, 249 p. 13 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030556884
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Bioinformatics. ; Biomedical engineering. ; Biotechnology. ; Artificial intelligence. ; Neuroscience. ; Bioinformatics. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Artificial Intelligence.
    Description / Table of Contents: PART I. Basic -- Spinal Cord Injury -- Functional Electrical Stimulation -- Electroencephalography & Brain-Computer Interfaces -- PART II. Neuroprosthetics in SCI -- History of Neuroprosthetics -- Upper Extremity Neuroprosthetics for Spinal Cord Injury -- Neuro-Robotics: Rehabilitation and Restoration of Walking using Exoskeletons via Non-invasive Brain Machine Interfaces -- Epidural and Transcutaneous Spinal Cord Stimulation Strategies for Motor Recovery after Spinal Cord Injury -- PART III. Clinical Brain-Computer Interfaces -- P300 BCI for Persons with Spinal Cord Injury – a BCI in Search of an Application? -- Invasive BCI Approaches for Restoration of Upper Extremity Movements -- Towards Non-invasive BCI Based Movement Decoding -- PART IV. Clinical Use Cases and Practice -- Therapeutic Applications of Electrical Stimulation in Spinal Cord Injury -- Brain Computer Interface Controlled Functional Electrical Stimulation for Rehabilitation of Hand Function in People with Spinal Cord Injury -- Non-invasive Brain-Computer Interfaces for Control of Grasp Neuroprosthesis - The European MoreGrasp Initiative -- PART V. Outlook -- Therapies of the Future.
    Abstract: This book provides a comprehensive overview of the current state of the art of practical applications of neuroprosthesis based on functional electrical stimulation for restoration of motor functions lost by spinal cord injury and discusses the use of brain-computer interfaces for their control. The book covers numerous topics starting with basics about spinal cord injury, electrical stimulation, electrical brain signals and brain-computer interfaces. It continues with an overview of neuroprosthetic solutions for different purposes and non-invasive and invasive brain-computer interface implementations and presents clinical use cases and practical applications of BCIs. Finally, the authors give an outlook on cutting edge research with a high potential for clinical translation in the near future. All authors committed themselves to use easy-to-understand language and to avoid very specific information, focusing instead on the essential aspects. This makes this book an ideal choice not only for researchers and clinicians at all stages of their education interested in the topic of brain-computer interface-controlled neuroprostheses, but also for end users and their caregivers who want to inform themselves about the current technological possibilities to improve paralyzed motor functions. .
    Type of Medium: Online Resource
    Pages: X, 377 p. 114 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030685454
    DDC: 612.8
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Pharmaceutical chemistry. ; Pharmacovigilance. ; Neuroscience. ; Pharmaceutics. ; Drug Safety and Pharmacovigilance.
    Description / Table of Contents: PART I - Introduction -- Innovator, Entrepreneur, Leader: The Tripartite Drug Discovery Neuroscientist -- PART II - Innovation in the Discovery of Novel Therapeutic Approaches -- Drug Discovery in CNS: Finding a Target for What? -- Neurogenomics with Application to Schizophrenia and Other Major Neuropsychiatric Diseases with Complex Heredity -- Epigenetics in Drug Discovery: Achievements and Challenges -- Conventional Behavioral Models and Readouts in Drug Discovery: The Importance of Improving Translation -- Safety and Drug Metabolism: Toward NCE and First in Human -- The Various Forms of Non-invasive Brain Stimulation and Their Clinical Relevance -- Is Non-invasive Brain Stimulation the Low-Hanging Fruit? -- PART III - Translational Medicine and Technology -- Electrophysiology: From Molecule to Cognition, from Animal to Human -- MRI in CNS Drug Development -- Positron Emission Tomography in Drug Development -- Application of Cognitive Test Outcomes for Clinical Drug Development -- Exciting Research in the Field of Sexual Psychopharmacology: Treating Patients with Inside Information -- A Paradigm Shift from DSM-5 to Research Domain Criteria: Application to Translational CNS Drug Development -- PART IV - Clinical Development and Regulatory Approval -- The Special Challenges of Developing CNS Drugs -- Phase 1 Clinical Trials in Psychopharmacology -- Early Development of Erenumab for Migraine Prophylaxis -- Microdosing Psychedelics as a Promising New Pharmacotherapeutic -- Partnering with the FDA.
    Abstract: This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.
    Type of Medium: Online Resource
    Pages: XIV, 283 p. 54 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030623517
    DDC: 612.8
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: (R)-ketamine: A new rapid-acting antidepressant -- (2R,6R)-hydroxynorketamine, a metabolite of ketamine: the antidepressant actions and the mechanisms -- Predictable biomarkers for rapid-acting antidepressant response to ketamine -- Nitrous Oxide: an old compound with emerging psychotropic properties -- Novel AMPA receptor potentiators TAK-137 and TAK-653 as potential rapid-acting antidepressants -- AMPA receptor potentiators as potential rapid-acting antidepressants -- mGlu2/3 receptor antagonists as rapid-acting antidepressants -- Antidepressant effects of the muscarinic receptor antagonist scopolamine: Clinical and preclinical review.
    Abstract: This book discusses new candidates for rapid-acting antidepressants, such as (R)-ketamine, (2R,6R)-hydroxynorketamine, scopolamine, mGluR2/3 antagonists and AMPA receptor agonists. There are serious limitations to currently available antidepressants, such as delayed onset and low rates of efficacy. The discovery that a single dose of ketamine, an NMDAR antagonist, can produce rapid antidepressant effects that are sustained has led to new research in this area. In this volume, a variety of novel pharmaceutical treatments are examined. This volume would be useful to both researchers and clinicians who work in the field of pharmacology, specifically CNS drug treatments. Discusses new candidate for rapid-acting antidepressants Provides information for those who work in the field of CNS drugs Ideal for pharmacologists, psychiatrists, and those who want to learn about CNS drugs at the graduate level.
    Type of Medium: Online Resource
    Pages: VII, 149 p. 14 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030797904
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 72
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroanatomy. ; Endocrine glands. ; Neuroscience. ; Neuroanatomy. ; Endocrine System.
    Description / Table of Contents: PART I. Structural Components of the Neuroendocrine Systems -- Chapter 1. Ontogenesis of Hypothalamic Neurons in Mammals -- Chapter 2. Advances in MRI-Based Anatomy of the Human Hypothalamus and Effects of the Hypothalamic Neuropeptide Oxytocin on Brain BOLD Signals -- Chapter 3. Generation of Hypothalamus and Adenohypophysis from Human Pluripotent Stem Cells -- Chapter 4. The Neurohypophysis and Urophysis - Ancient Piscine Neurovascular Interfaces -- Chapter 5. Cytoskeletal Organization and Plasticity in Magnocellular Neurons -- PART II. Neuroanatomy of Hypothalamo-hypophyseal Systems -- Chapter 6. Neuroanatomical and Functional Relationship Between Parvocellular and Magnocellular Oxytocin and Vasopressin Neurons -- Chapter 7. Fine Chemo-Anatomy of Hypothalamic Magnocellular Vasopressinergic System with an Emphasis on Ascending Connections for Behavioural Adaptation -- Chapter 8. Neuroanatomy of the GnRH/Kisspeptin System -- Chapter 9. Corticotropin-Releasing Hormone in the Paraventricular Nucleus of the Hypothalamus- Beyond Hypothalamic-Pituitary-Adrenal Axis Control -- Chapter 10. Multifactorial Regulation of the Activity of Hypophysiotropic Thyrotropin-Releasing Hormone Neurons -- PART III. Hypothalamic Control of Neuroendocrine Functions -- Chapter 11. Circadian Control of Neuroendocrine Systems -- Chapter 12. The Neuroanatomical Organization of Hypothalamic Feeding Circuits -- Chapter 13. Melanin-Concentrating Hormone, Neuropeptide E-I, and MCH Receptor 1 -- Chapter 14. Neuroanatomy of Tuberoinfundibular Peptide 39 Related to Neuroendocrine and Behavioral Regulations -- Chapter 15. Functional Chemoanatomy of PACAP in Neuroendocrine and Neuronal Circuits -- Chapter 16. Functional Neuroanatomy of Relaxin-3/RXFP3 Systems in the Brain: Implications for Integrated Neuroendocrine and Behavioural Control.
    Abstract: In this book, experts in the field provide comprehensive descriptions of the neuroanatomy of the hypothalamic neuroendocrine systems. The book begins with an extensive discussion on the structural components of the neuroendocrine systems. The reader will be introduced to the anatomy and biology of the hypothalamus and the pituitary. The human hypothalamus is presented in particular detail using state-of-the-art imaging techniques. In the next section, the neuroanatomy of traditional hypothalamo-hypophyseal systems is highlighted, with chapters describing magnocellular neuroendocrine cells and discussing the respective types of hypothalamic neurons that regulate various pituitary hormones. Following this detailed structural and anatomical description of the neuroendocrine system, the book’s final section focuses on the hypothalamic control of neuroendocrine functions. This includes the control of circadian rhythm, metabolism and appetite via specific peptidergic circuits. This book provides essential information on the neuroanatomy and control of neuroendocrine systems, addresses cutting-edge research questions posed by recent advances in the development of potent neuroanatomical tools, and highlights the latest technologies used in neuroendocrinology research, making it a valuable reference guide for students, trainees and established researchers alike. This is the twelfth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series, which aims to illustrate the highest standards and to encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. Chapter 12 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: X, 519 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030866303
    Series Statement: Masterclass in Neuroendocrinology, 12
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Biotechnology. ; Pharmacology. ; Neuroscience. ; Biotechnology. ; Pharmacology.
    Description / Table of Contents: Epidemiology of tinnitus -- Genetics and tinnitus -- Pharmacological modelling of tinnitus in animals -- Animal models of sensory and brain stimulation effects on tinnitus -- Cochlear damage and the mechanisms of tinnitus - implications for treatments -- Functional neuroanatomy of tinnitus -- Neuroinflammation and tinnitus -- Using big data to guide therapy development -- Pharmacoltherapy for tinnitus -- Sound therapy devices and mechanisms -- Cochlear electrical stimulation -- Brain stimulation -- Biomodal stimulation -- Effect of tinnitus on attention and cognition -- Neurobiology of stress induced tinnitus -- Behavioral correlates of tinnitus -- Psychological aprroaches to tinnitus management -- Momentary evaluation -- Questionnaires -- Psychoacoustic evaluation of tinnitus.
    Abstract: The origins of tinnitus and the development of effective treatments to treat tinnitus have puzzled scientists and clinicians for centuries. Now ground breaking research is beginning to unlock its secrets. The Behavioral Neuroscience of Tinnitus provides critical and comprehensive discussions of the most recent developments in behavioral neuroscience research of tinnitus. Each chapter represents the most important contemporary account of the subject, with an emphasis on preclinical and clinical trials for the development of new diagnostics and therapeutics. New and emerging innovative approaches are covered whenever possible. Six topics are discussed in detail in this volume, which provide new insights in the etiology and mechanisms of tinnitus, new biomarkers towards objective and reliable diagnosis of tinnitus, pharmacological approaches towards curing tinnitus, bioengineering advances towards developing effective medical devices, as well as the latest in psychotherapy methods. The reviews in the volume expose researchers and clinicians, both new and experienced, to exciting advancements and state-of-the-art developments from preeminent researchers in the field of tinnitus.
    Type of Medium: Online Resource
    Pages: XI, 487 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030855031
    Series Statement: Current Topics in Behavioral Neurosciences, 51
    DDC: 612.8
    Language: English
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  • 74
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Translational Neuroscience of Speech and Language Disorders: State of the Art. -2. Translational Neuroscience of Aphasia and Adult Language Rehabilitation. -3. Treatment and intervention approaches for the improvement of language abilities in neurodegenerative diseases -- 4. Neural and Genetic Mechanisms of Dyslexia -- 5. The role of memory systems in neurodevelopmental disorders of language -- 6. Transcranial direct current stimulation (tDCS) and Language/Speech: Can patients benefit from a combined therapeutic approach? -- 7. Transcranial Magnetic Stimulation in Aphasia Rehabilitation -- 8. The Cerebellum: A Therapeutic Target in Treating Speech and Language Disorders -- 9. Navigated rTMS for Mapping the Language Network in Preoperative Settings: Current Status and Future Prospects -- 10. Presurgical Language fMRI in Epilepsy: An Introduction -- 11. Lesion-symptom mapping in speech and language disorders: a translational perspective.
    Abstract: This edited volume provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative conditions on speech and language. It brings together contributions from several leading experts in a markedly broad range of disciplines, including Speech and Language Therapy, Neuropsychology and Neurology, but also Neurosurgery, Neuroimaging and Neurostimulation, as well as Engineering and Genetics.
    Type of Medium: Online Resource
    Pages: XVII, 290 p. 18 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356873
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 75
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Anatomy. ; Internal medicine. ; Cytology. ; Biochemistry. ; Neuroscience. ; Anatomy. ; Internal Medicine. ; Cell Biology. ; Biochemistry.
    Description / Table of Contents: Neurosecretion: A Historical Overview -- Neurosecretion: Hypothalamic Somata versus Neurohypophysial Terminals -- Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus -- Somato-Dendritic Secretion of Neuropeptides -- Neurosecretory Vesicles: Structure, Distribution, Release and Breakdown -- Molecular Controls on Regulated Neurotransmitter and Neurohormone Secretion -- Secretory Astrocytes -- Action Potential-Induced Ca2+ Influx for Both Acute and Sustained Insulin Secretion in Pancreatic Beta Cells -- Plasticity in the Morphology of Lactotrophs and Folliculo-Stellate Cells and Prolactin Secretion -- Neuroendocrine and Metabolic Regulation of Plasma Growth Hormone Secretory Profiles -- Role of the TWIK-Related Potassium (TREK)-1 Channels in the Regulation of Adrenocorticotropic Hormone (ACTH) Secretion from Pituitary Corticotropes -- How Do Bacterial Neurotoxins Affect Neurosecretion? -- Secretory Mechanisms in Paramecium.
    Abstract: How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state‐dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley.
    Type of Medium: Online Resource
    Pages: XIII, 307 p. 65 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030229894
    Series Statement: Masterclass in Neuroendocrinology, 8
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Description / Table of Contents: Ch 1: Listening to All Voices: Interdisciplinary Approaches to Understanding Hearing in Aging -- Ch 2: Genetic and Molecular Aspects of the Aging Auditory System -- Ch 3: The Aging Cochlea and Auditory Nerve -- Ch 4: Age-Related Changes in the Auditory Brainstem and Inferior Colliculus -- Ch 5: Age related changes in the primate auditory cortex -- Ch 6: The Aging Auditory System: Electrophysiology -- Ch 7: Age-Related Changes in Segregation of Sound Sources -- Ch 8: Causes and Consequences of Age-Related Hearing Loss -- Ch 9: Age-Related Changes in Speech Understanding: Peripheral versus Cognitive Influences -- Ch 10: Aging, Hearing Loss, and Listening Effort: Imaging Studies of the Aging Listener -- Ch 11: Functional Consequences of Impaired Hearing in Older Adults and Implications for Intervention -- Ch 12: Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss.
    Abstract: This volume provides contemporary discussions on new developments in aging research. It serves as an important update on the current state of research on the aging auditory system. Listening to All Voices: Interdisciplinary Approaches to Understanding Hearing in Aging Karen S. Helfer and Edward L. Bartlett Genetic and Molecular Aspects of the Aging Auditory System Shinichi Someya and Mi-Jung Kim The Aging Cochlea and Auditory Nerve Kevin K. Ohlemiller and Christopher Spankovich Age-Related Changes in the Auditory Brainstem and Inferior Colliculus Josef Syka Age-Related Changes in the Primate Auditory Cortex Gregg Recanzone The Aging Auditory System: Electrophysiology Kelly C. Harris Age-Related Changes in Segregation of Sound Sources Frederick J. Gallun and Virginia Best Causes and Consequences of Age-Related Hearing Loss Jennifer A. Deal, Nicholas S. Reed, Emily C. Pedersen, and Frank R. Lin Age-Related Changes in Speech Understanding: Peripheral versus Cognitive Influences Sandra Gordon-Salant, Maureen J. Shader, and Arthur Wingfield Aging, Hearing Loss, and Listening Effort: Imaging Studies of the Aging Listener Stefanie E. Kuchinsky and Kenneth I. Vaden, Jr. Functional Consequences of Impaired Hearing in Older Adults and Implications for Intervention Larry E. Humes, M. Kathleen Pichora-Fuller, and Louise Hickson Emerging Clinical Translational Treatment Strategies for Age-Related Hearing Loss Robert D. Frisina, Carlos J. Cruz, Tanika T. Williamson, Xiaoxia Zhu, and Bo Ding .
    Type of Medium: Online Resource
    Pages: XVII, 323 p. 62 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030493677
    Series Statement: Springer Handbook of Auditory Research, 72
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Introduction Food and Brain -- 2. Food and Behavior -- 3. Food and Psychological Wellbeing -- 4. Food and Cognition -- 5. Autism and Food -- 6. Healthy Brains: Types of Food and their Active Pharmacological Ingredients -- 5. Dieting: Importance of Diet and Diet Types -- 6. Nutrigenomics -- 7. Epigenetics -- 8. Gut Microbiota (microbiome) -- 9. Personalized Nutrition -- 10. Vegetables -- 11. Fruits -- 12. Nuts, Seeds and Spices -- 13. Grains [Oats, Barley & Quinoa] -- 14. Seafood [fish like Salmon, Oyster, Sea vegetables (algae)] -- 15. Other -- 16. Autism Management through Food and Diet -- 17. Personalized Nutrition Therapy.
    Abstract: The book focuses on implications of traditional and processed foods for autism spectrum disorder (ASD) intervention and management. Numerous phytonutrients and pharmacologically active compounds in edible natural products and diet could influence and offer protection to neuronal dysfunction that occurs due to ASD. The neuroprotective effects of various fruits, vegetables, nuts and seeds phytochemicals, and other natural bioactive ingredients against ASD and related conditions are discussed. Topics such as the possible neuroprotective mechanism of action of these foods and the therapeutic role of antioxidants in relation to ASD are addressed. This book also highlights the scope of using anti-inflammatory agents and antioxidants to promote neurogenesis and improve other symptoms in ASD. It emphasizes personalized nutritional approaches with dietary management of neurodevelopmental disorders/ASD cases. Information in this book is relevant to researchers in the field of complementary and alternative medicine, nutraceuticals, neuroscience, agriculture, nutrition, and food science. This volume is beneficial to students of varying levels, and across multiple disciplines.
    Type of Medium: Online Resource
    Pages: XX, 693 p. 111 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030304027
    Series Statement: Advances in Neurobiology, 24
    DDC: 612.8
    Language: English
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  • 78
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Psychobiology. ; Human behavior. ; Semiotics. ; Communication. ; Ethnology. ; Social sciences. ; Humanities. ; Behavioral Neuroscience. ; Semiotics. ; Media and Communication. ; Ethnography. ; Humanities and Social Sciences.
    Description / Table of Contents: Chapter 1: Bateson, Cybernetics, and Nonverbal Communication -- Chapter 2: Analog and Digital Communication, and Similar Contrasts -- Chapter3: The Slash Mark: Gregory Bateson’s Cybernetic Semiotic -- Chapter4: Intention Movements and Peacemaking Ceremonies -- Chapter5: Relational Communication in Octopus -- Chapter6: Cuban Missile Crisis -- Chapter7: False and True Lessons from the Cuban Missile Crisis -- Chapter8: A Level too Low.
    Abstract: This book develops Gregory Bateson’s ideas regarding “communication about relationship” in animals and human beings, and even nations. It bases itself on Bateson’s theory of relational communication, as he described it in the zoosemiotics of octopus, mammals, birds, and human beings. This theory includes, for example, the roles of metaphor, play, analog and digital communication, metacommunication, and Laws of Form. It is organized around a letter from Gregory Bateson to his fellow cybernetic thinker Warren McCulloch at the time of the Cuban Missile Crisis. In this letter Bateson argued that what we would today call zoosemiotics, including Bateson’s own (previously unpublished) octopus research, should be made a basis for understanding the relationship between the two blocs of the Cold War. Accordingly the book shows how Bateson understood interactive processes in the biosemiotics of conflict and peacemaking, which are analyzed using examples from recent animal studies, from primate studies, and from cultural anthropology. The Missile Crisis itself is described in terms of Bateson’s critique of game theory which he felt should be modified by an understanding of the zoosemiotics of relational communication. The book also includes a previously unpublished piece by Gregory Bateson on wolf behavior and metaphor/ abduction.
    Type of Medium: Online Resource
    Pages: XIX, 189 p. 7 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030521011
    Series Statement: Biosemiotics, 20
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Endocrine glands. ; Neuroscience. ; Endocrine System.
    Description / Table of Contents: Photoperiodism and Circannual Timing: Introduction and Historical Perspective.-The Pars Tuberalis and Seasonal Timing -- Tanycytes and Their Pivotal Role in Seasonal Physiological Adaptations -- Epigenetic Mechanisms in Developmental and Seasonal Programs -- Plasticity of Neuroendocrine Mechanisms Regulating Seasonal Reproduction in Sheep -- Clocks and Calendrars in Birds -- Calendar Timing in Teleost Fish -- Action of Light on the Neuroendocrine Axis -- Seasons, Clocks, and Mood -- Photoperiodic Modulation of Clock Gene Expression in the SCN -- Circadian Timekeeping in the Suprachiasmatic Nucleus: Genes, Neurotransmitters, Neurons and Astrocytes. .
    Abstract: This book explores how daily and seasonal rhythmicity is generated, how these rhythms are synchronised by our environment, and how they regulate the neuroendocrine systems that impact our physiology and behaviour. The constraints of surviving in a seasonal environment have shaped human evolution and migration, have shaped our societies and cultures, and continue to influence our everyday lives, health and wellbeing. Identifying the mechanisms whereby seasonal rhythmicity is generated and regulates the brain and body is not only important for understanding the natural world and relevant to animal production, it also offers many insights into the human condition. Each chapter is written by an international expert in the field of chronobiology. A historical perspective on how research into photoperiodism and rhythmicity progressed is initially provided, but the main focus of this book is on the remarkable studies in the last few decades that have unravelled the molecular and cellular machinery underpinning circadian and circannual timing. Topics covered include the role of melatonin in communicating seasonal information to the brain and pituitary gland, the neuroanatomical pathways in mammals, birds and fish by which changes in photoperiod reach the hypothalamus, the role of glial cells (tanycytes) and thyroid hormone in seasonal rhythmicity, neuroplasticity across seasons, effects of changing day length on mood, regulation of “clock“ gene expression, and the role of the suprachiasmatic nucleus. This book will appeal to all students and researchers who wish to learn about current and past research on daily and seasonal rhythmicity. This is the tenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. .
    Type of Medium: Online Resource
    Pages: XII, 244 p. 64 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030556433
    Series Statement: Masterclass in Neuroendocrinology, 10
    DDC: 612.8
    Language: English
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  • 80
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Psychobiology. ; Human behavior. ; Animal migration. ; Biology Technique. ; Physiology. ; Behavioral Neuroscience. ; Animal Migration. ; Experimental Organisms. ; Animal Physiology.
    Description / Table of Contents: Preface -- Chapter 1. Studying Birds -- Chapter 2. Mapping Sentences and Facet Theory -- Chapter 3. How to Develop a Mapping Sentence: The Example of Avian Sleep -- Chapter 4. Complex Avian Behaviour and Cognition: A Mapping Sentence Approach -- Chapter 5 -- Studying Avian Cognition in the Wild: Avian Psychometrics -- Chapter 6. Interpreting Avian Play, Murmuration of Starlings and Oology (Classifying Birds' Eggs) -- Chapter 7. Conclusion -- Glossary -- Index.
    Abstract: This book presents the facet theoretical framework as a tool for facilitating the conception of complex animal behaviour research and the design of research procedures through employing mapping sentences. Using the facet theoretical framework, this book takes a holistic view of bird behaviour. Components of bird behavior are identified and then reassembled to facilitate an understanding of the behaviour in the context of its natural occurrence. This provides new insight on both the parts of the behaviour and how these interact as a whole. The multi-faceted approach to designing, evaluating and understanding bird behavior presented offers a template that is adaptable for investigating a wide variety of avian species and different forms of behaviour. Behavioural biologists, animal and comparative psychologists, other natural and behavioural scientists, as well as students of these disciplines will find this book to be an interesting and enlightening read.
    Type of Medium: Online Resource
    Pages: XXXVII, 203 p. 29 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030121921
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Abstract: This volume focuses on new molecular therapies that aim to prevent specific pathologies of the ear, like age-related hearing loss, noise-induced hearing loss and ototoxicity. The book discusses the regenerative capacity of hair cells in the inner ear, exploring the idea that hair cells’ capacity to regenerate appears “repressed” in adult mammals, but that it will be possible to re-activate regeneration with an appropriate therapeutic approach. The book provides an overview of inflammatory and immune cells in the cochlear lateral wall, the pathways involved in cochlear damage, and their potential as therapeutic targets. It also describes the significant advances in animal models which play an important role in revealing the underlying mechanisms and treatment for tinnitus and hyperacusis. Finally, the book describes two new automatic and robust measures to evaluate hearing loss and tinnitus in preclinical models.
    Type of Medium: Online Resource
    Pages: VII, 186 p. 29 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030404130
    DDC: 612.8
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Bioethics. ; Security, International. ; Security systems. ; Neuroscience. ; Bioethics. ; International Security Studies. ; Security Science and Technology.
    Description / Table of Contents: 1. Modern Neuroscience -- 2. The Chemical and Biological Non-Proliferation Regime in 2018 -- 3. Neuroethics and the Regulation of Misuse -- 4. Dual-Use Neuroscience? -- 5. The EU Human Brain Project -- 6. The US BRAIN Initiative -- 7. Global Neuroethics in Early 2019 -- 8. Japan’s BRAIN/Minds Project -- 9. China’s Brain Project -- 10. Conclusion.
    Abstract: After COVID-19 ensuring biological security will be a critical necessity. Neuroscience and the Problem of Dual Use focuses on the fact that benignly intended research in the life sciences could be misused for hostile purposes. It details the revolution that is taking place in neuroscience during this period of instability in international security, describes the new major State-funded brain research projects, and suggests ways in which hostile misuse could be prevented in coming decades.
    Type of Medium: Online Resource
    Pages: XXV, 210 p. 4 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030537906
    Series Statement: Advanced Sciences and Technologies for Security Applications,
    DDC: 612.8
    Language: English
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  • 83
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Modeling neurodevelopmental deficits in Tuberous Sclerosis Complex with stem cell-derived neural precursors and neurons -- 2. Advances in human stem cells and genome editing to understand and develop treatment for Fragile X syndrome -- 3. IPSC MODELS OF CHROMOSOME 15Q IMPRINTING DISORDERS: FROM DISEASE MODELING TO THERAPEUTIC STRATEGIES -- 4. Creating iPSC based models to understand the signaling and cellular phenotypes in idiopathic autism and 16p11.2 derived neurons -- 5. Dysregulation of Neurite Outgrowth and Cell Migration in Autism and other Neurodevelopmental Disorders -- 6. Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells -- 7. Modeling Inflammation on Neurodevelopmental disorders using pluripotent stem cells -- 8. Astrocyte-derived exosomes in an iPSC model of bipolar disorder -- 9. Two- and there-dimensional stem cell models to define mechanisms underlying psychiatric disorders -- 10. Development of a 3-D organoid system using human induced pluripotent stem cells to model idiopathic autism.
    Abstract: This book contains a compendium of induced pluripotent stem cells (iPSCs) articles and reviews concerning state of the art technologies and how they are being applied to human neurodevelopmental disorders. With the establishment of effective technologies to produce iPSCs and their derivatives, like neural precursors, neurons, and glia, researchers have new platforms to study neurodevelopmental disorders. iPSC technology enables researchers to study how human neurons develop in individuals with neurodevelopmental disorders, providing an unparalleled opportunity to investigate their etiology. In turn, researchers have now begun to understand the underlying molecular and cellular pathways that contribute to human diseases. iPSCs technologies also provide an emerging tool for future translational studies and disease classification. The chapters will emphasize how among the diverse idiopathic and genetic disorders, there are common clinical as well as cellular and molecular phenotypes.
    Type of Medium: Online Resource
    Pages: IX, 305 p. 26 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030454937
    Series Statement: Advances in Neurobiology, 25
    DDC: 612.8
    Language: English
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  • 84
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Biomedical engineering. ; Neurology . ; Radiology. ; Biophysics. ; Neuroscience. ; Biomedical Engineering and Bioengineering. ; Neurology. ; Radiology. ; Biophysics.
    Description / Table of Contents: Introduction to Neurophysiology -- Biopotential Measurements and Electrodes -- EEG Signal Processing: Theory and Applications -- Brain-Computer Interfaces -- Intracortical Brain Machine Interfaces -- Deep Brain Stimulation: Emerging Technologies and Applications -- Transcranial Magnetic Stimulation: Principles and Applications -- Transcranial Electrical Stimulation -- Optogenetics: Novel Brain Interface Technology that Originates in Bioprospecting -- Selective Chronic Recording in the Peripheral Nervous System -- Functional Magnetic Resonance Imaging -- Photoacoustic Tomography of Neural Systems -- Electrophysiological Mapping and Source Imaging -- Exploring Functional and Causal Connectivity in the Brain -- Deep Learning Models with Applications to Brain Image Analysis -- Neural Modeling -- Linear Dynamics & Control of Brain Networks -- Deciphering the Neuronal Population Code -- Machine Intelligence Based Epileptic Seizure Forecasting -- Retinal Prosthesis -- Retinal Bioengineering -- Neural Tissue Engineering -- Index.
    Abstract: This third edition overviews the essential contemporary topics of neuroengineering, from basic principles to the state-of-the-art, and is written by leading scholars in the field. The book covers neural bioelectrical measurements and sensors, EEG signal processing, brain-computer interfaces, implantable and transcranial neuromodulation, peripheral neural interfacing, neuroimaging, neural modelling, neural circuits and system identification, retinal bioengineering and prosthetics, and neural tissue engineering. Each chapter is followed by homework questions intended for classroom use. This is an ideal textbook for students at the graduate and advanced undergraduate level as well as academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals seeking to learn the latest developments in this emerging field. Advance Praise for Neural Engineering, 3rd Edition: “A comprehensive and timely contribution to the ever growing field of neural engineering. Bin He’s edited volume provides chapters that cover both the fundamentals and state-of-the-art developments by the world’s leading neural engineers." Dr. Paul Sajda, Department of Biomedical Engineering, Electrical Engineering and Radiology, Columbia University “Neural Engineering, edited by Prof. He, is an outstanding book for students entering into this fast evolving field as well as experienced researchers. Its didactic and comprehensive style, with each chapter authored by leading scientific authorities, provides the ultimate reference for the field.” Dr. Dario Farina, Department of Bioengineering, Imperial College London, London, UK "Neural Engineering has come of age. Major advances have made possible prosthesis for the blind, mind control for quadraplegics and direct intervention to control seizures in epilepsy patients. Neural Engineering brings together reviews by leading researchers in this flourishing field. Dr. Terrence Sejnowski, Salk Institute for Biolgical Studies and UC San Diego.
    Type of Medium: Online Resource
    Pages: XVI, 699 p. 407 illus., 299 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030433956
    DDC: 612.8
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medical genetics. ; Neuroscience. ; Medical Genetics.
    Description / Table of Contents: A hypothesis of circulated microRnas implication in high incidence of atrial fibrillation and other electrocardiographic abnormalities in cancer patients -- Central Line-associated Bloodstream Infections (CLABSI) Incidence and the role of obesity: a prospective, observational study in Greece -- Number of brain states in an N-body dynamical scenario according to the universal Bekenstein entropy bound -- Burden and sleeping disorders of family caregivers of Hemodialysis patients with Chronic Kidney Disease-End Stage. A cross-sectional study -- Quality of life in type 2 diabetes mellitus patients with neuropsychological deficits -- A framework for assessing the impact of information seeking behavior on cancer patients’ long-term prognosis -- Sleeping Disorders and Health Related Quality of Life in Hemodialysis patients with Chronic Renal Disease in Greece -- Subjective Quality of Life, Religiousness and Spiritual Experience in Greek Orthodox Christians: Data from Healthy Aging and Patients with Cardiovascular Disease -- Mini-Mental State Examination: Greek normative data stratified by age and education in a large sample of 925 community-dwelling healthy participants -- The role of the family in the care of Alzheimer patients -- Prevalence of Stroke Cases in Warangal, Telangana Region, India: A Hospital-Based Case Study -- Compliance of Patients with Acute Coronary Syndrome with treatment following their hospitalization from the Cardiac Coronary Unit -- Using a Virtual Reality Serious Game to Assess the Performance of Older Adults with Frailty -- Characteristics and survival rates in ward patients requiring evaluation by Intensivist in Greece.
    Abstract: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people.
    Type of Medium: Online Resource
    Pages: X, 155 p. 10 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030326371
    Series Statement: Advances in Experimental Medicine and Biology, 1196
    DDC: 612.8
    Language: English
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  • 86
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    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuropsychology. ; Psychology, Pathological. ; Therapeutics. ; Pharmacology. ; Psychology. ; Neuroscience. ; Neuropsychology. ; Psychopathology. ; Therapeutics. ; Pharmacology. ; Behavioral Sciences and Psychology.
    Description / Table of Contents: Chapter 1. Epidemiology of Binge Eating -- Chapter 2. Binge Eating Assessement -- Chapter 3. Developmental and Cultural Aspects of Binge Eating -- Chapter 4. Psychosocial Correlates of Binge Eating -- Chapter 5. Weight Dysregulation, Positive Energy Balance and Binge Eating in Eating Disorders -- Chapter 6. Theoretical Development and Maintenance Models of Binge Eating -- Chapter 7. Preclinical Models of Stress and Environmental Influences on Binge Eating -- Chapter 8. Emerging Translational Treatments to Target the Neural Networks of Binge Eating -- Chapter 9. Neuroimaging to Study Brain Reward Processing and Reward-Based Learning in Binge Eating Pathology -- Chapter 10. The Neurobiological Basis of Executive Function Alterations in Binge Eating Populations -- Chapter 11. Influence of Genetics and Sex Hormones on Binge Eating -- Chapter 12. Neuroendocrine Correlates of Binge Eating -- Chapter 13. Body Image Disturbance and Binge Eating -- Chapter 14. Food Addiction, Binge Eating and the Role of Dietary Restraint: Converging Evidence from Animal and Human Studies -- Chapter 15. Prevention of Binge Eating -- Chapter 16. Medication for Binge Eating -- Chapter 17. Oxytocin: Potential New Treatment for Binge Eating -- Chapter 18. Psychotherapy for Binge Eating -- Chapter 19. Self Help Interventions for the Treatment of Binge Eating -- Chapter 20. New Avenues for the Treatment of Binge Eating based on Implicit Processes -- Chapter 21. Binge-Eating Disorder: Unanswered Questions -- Chapter 22. Overcoming Barriers to the Treatment of Binge Eating.
    Abstract: This book provides a comprehensive overview of our current understanding of binge eating, which is characterized by the uncontrollable consumption of large amounts of food in a discrete time period. Written by experts on eating disorders, it first introduces the phenotype of binge eating, including its epidemiology and assessment. It then describes the underlying neurobiological alterations, drawing on cutting-edge animal models and human studies to do so. In addition, it extensively discusses current treatment models, including medication, psychotherapy, self-interventions and disease prevention. Lastly, an outlook on the future research agenda rounds out the coverage. Given binge eating’s current status as an under-researched symptom, but one shared across many eating disorders, this book provides an up-to-date, integrative and comprehensive synthesis of recent research and offers a valuable reference for scientists and clinicians alike.
    Type of Medium: Online Resource
    Pages: X, 321 p. 14 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030435622
    DDC: 612.8
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Anatomy. ; Internal medicine. ; Neuroscience. ; Anatomy. ; Internal Medicine.
    Description / Table of Contents: Part I. Molecular Specification of Hypothalamic/Pituitary Cells -- Development of the Neuroendocrine Hypothalamus -- Sonic hedgehog in Hypothalamus Development -- Development of the Hypothalamus in Xenopus laevis -- Gene Regulatory Programs in the Development of Hypothalamic Arcuate Nucleus Neurons -- Winding the Clock: Development of Hypothalamic Structures Controlling Biological Timing and Sleep -- Pituitary Development and Organogenesis: Transcription Factors in Development and Disease -- Part II. Developmental Modulators and Epigenetic Factors -- Hypothalamic Development: Role of GABA -- Epigenetic and Transcriptional Regulation of the Reproductive Hypothalamus -- Epigenetic Regulation of the GnRH and Kiss1 Genes: Developmental Perspectives -- Imprinted Genes and Hypothalamic Function -- Rhythmic Epigenetics in Neuroendocrine and Immune Systems -- Part III. Development of Neuroendocrine Circuits -- Development of Limbic System Stress-Threat Circuitry -- Organization and Postnatal Development of Visceral Sensory Inputs to the Neuroendocrine Hypothalamus -- Astrocytes and Development of Neuroendocrine Circuits -- Origins of Sex Differentiation of Brain and Behavior -- Development and Modulation of Female Reproductive Function by Circadian Signals.
    Abstract: In this book, experts in the field discuss the latest research in developmental neuroendocrinology. Given that the hypothalamus is the center of neuroendocrine activity, the reader will learn about the molecular specification of hypothalamic cells, developmental modulators and epigenetic factors influencing hypothalamic development, and the development of neuroendocrine circuits. Each chapter provides a concise review of the current and future perspectives in developmental neuroendocrinology. Important insights into state-of-the-art techniques applied to functional circuit tracking, lineage tracing of hypothalamic cells, and the identification of genes altered through epigenetic mechanisms are also provided. Given its scope, the book will appeal to all students and researchers who are eager to understand the processes involved in hypothalamus development and the establishment of neuroendocrine circuits. This is the ninth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series* that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. *Volumes 1-7 published by Wiley.
    Type of Medium: Online Resource
    Pages: X, 468 p. 85 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030400026
    Series Statement: Masterclass in Neuroendocrinology, 9
    DDC: 612.8
    Language: English
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  • 88
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    Cham :Springer International Publishing :
    Keywords: Psychobiology. ; Human behavior. ; Evolution (Biology). ; Acoustics. ; Vertebrates. ; Coding theory. ; Information theory. ; Communication. ; Behavioral Neuroscience. ; Evolutionary Biology. ; Acoustics. ; Vertebrate Zoology. ; Coding and Information Theory. ; Media and Communication.
    Description / Table of Contents: Acoustic Coding Strategies Through the Lens of the Mathematical Theory of Communication -- To Shout or to Whisper? Strategies for Encoding Public and Private Information in Sound Signals -- The Bird Dawn Chorus Revisited -- Coding Human Languages for Long-Range Communication in Natural Ecological Environments: Shouting, Whistling, and Drumming -- Coding of Static Information in Terrestrial Mammal Vocal Signals -- Coding for ‘Dynamic’ Information: Vocal Expression of Emotional Arousal and Valence in Non-human Animals -- Seasonal Hormone Fluctuations and Song Structure of Birds -- From Vocal to Neural Encoding: A Transversal Investigation of Information Transmission at Long Distance in Birds -- Mother–Offspring Vocal Recognition and Social System in Pinnipeds -- Acoustic Coding of Information in a Complex Social Network: Identity Signaling in Northern Elephant Seals -- How Songbird Females Sample Male Song: Communication Networks and Mate Choice -- Interspecific Communication: Gaining Information from Heterospecific Alarm Calls -- A Framework to Understand Interspecific Multimodal Signaling Systems.
    Abstract: Information is a core concept in animal communication: individuals routinely produce, acquire, process and store information, which provides the basis for their social life. This book focuses on how animal acoustic signals code information and how this coding can be shaped by various environmental and social constraints. Taking birds and mammals, including humans, as models, the authors explore such topics as communication strategies for “public” and “private” signaling, static and dynamic signaling, the diversity of coded information and the way information is decoded by the receiver. The book appeals to a wide audience, ranging from bioacousticians, ethologists and ecologists to evolutionary biologists. Intended for students and researchers alike, it promotes the idea that Shannon and Weaver’s Mathematical Theory of Communication still represents a strong framework for understanding all aspects of the communication process, including its dynamic dimensions.
    Type of Medium: Online Resource
    Pages: X, 325 p. 55 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030392000
    Series Statement: Animal Signals and Communication, 7
    DDC: 612.8
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: A Review of the Cholinergic System and Therapeutic Approaches to Treat Brain Disorders -- Acetylcholine and Spontaneous Recognition Memory in Rodents and Primates -- Endogenous Acetylcholine and Its Modulation of Cortical Microcircuits to Enhance Cognition -- Cholinergic Signaling Dynamics and Cognitive Control of Attention -- Involvement of Nicotinic Receptors in Working Memory Function -- Nicotinic Receptors Underlying Nicotine Dependence: Evidence fromTransgenic Mouse Models -- Cholinergic Receptors and Addiction -- Behavioral and Molecular Basis of Cholinergic Modulation of Pain: Focus on Nicotinic Acetylcholine Receptors -- An Evolving Therapeutic Rationale for Targeting the α7 Nicotinic Acetylcholine Receptor in Autism Spectrum Disorder -- Activators of α7 nAChR as Potential Therapeutics for Cognitive Impairment.
    Abstract: The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
    Type of Medium: Online Resource
    Pages: X, 245 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030560133
    Series Statement: Current Topics in Behavioral Neurosciences, 45
    DDC: 612.8
    Language: English
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    Keywords: Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Description / Table of Contents: Scaling the Levels of Birdsong Analysis -- Neural Circuits Underlying Vocal Learning in Songbirds -- New Insights into the Avian Song System and Neuronal Control of Learned Vocalizations -- The Song Circuit as a Model of Basal Ganglia Function -- Integrating Form and Function in the Songbird Auditory Forebrain -- Hormonal Regulation of Avian Auditory Processing -- The Neuroethology of Vocal Communication in Songbirds: Production and Perception of a Call Repertoire -- Linking Features of Genomic Function to Fundamental Features of Learned Vocal Communication -- Vocal Performance in Songbirds: From Mechanisms to Evolution.
    Abstract: This volume provides comprehensive, integrative, and comparative perspectives on birdsong and underscores the importance of birdsong research to behavioral and systems neuroscience, evolutionary biology, and biomedical research. Scaling the Levels of Birdsong Analysis Jon T. Sakata and Sarah C. Woolley Neural Circuits Underlying Vocal Learning in Songbirds Jon T. Sakata and Yoko Yazaki-Sugiyama New Insights into the Avian Song System and Neuronal Control of Learned Vocalizations Karagh Murphy, Koedi S. Lawley, Perry Smith, and Jonathan F. Prather The Song Circuit as a Model of Basal Ganglia Function Arthur Leblois and David J. Perkel Integrating Form and Function in the Songbird Auditory Forebrain Sarah C. Woolley and Sarah M. N. Woolley Hormonal Regulation of Avian Auditory Processing Luke Remage-Healey The Neuroethology of Vocal Communication in Songbirds: Production and Perception of a Call Repertoire Julie E. Elie and Frédéric E. Theunissen Linking Features of Genomic Function to Fundamental Features of Learned Vocal Communication Sarah E. London Vocal Performance in Songbirds: From Mechanisms to Evolution Jeffrey Podos and HaCheol Sung.
    Type of Medium: Online Resource
    Pages: XVIII, 268 p. 37 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030346836
    Series Statement: Springer Handbook of Auditory Research, 71
    DDC: 612.8
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Proteins. ; Cytology. ; Neuroscience. ; Proteins. ; Cell Biology.
    Description / Table of Contents: Preface -- Calcium signaling: from basics to bedside -- Measuring Ca2+ in living cells -- High-throughput fluorescence assays for Ion Channels and GPCRs -- Imaging Native Calcium Currents in Brain Slices -- Molecular diversity of plasma membrane Ca2+ transporting ATPases: their function under normal and pathological conditions -- A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders -- Cytoplasmic Calcium Buffering: An Integrative Crosstalk -- An update on calcium binding proteins -- Manuel Campos‐Toimil -- New insights in the IP3 receptor and its regulation -- Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca2+-release channels in the beta-cells and alpha- cells of the human islets of Langerhans -- Evolution of Excitation-Contraction Coupling -- Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels -- Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side -- Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores -- Calcium Signaling in the Heart -- Molecular basis and regulation of store-operated calcium entry -- Structure and activation mechanisms of CRAC channels -- Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells -- Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis -- Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels -- Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression -- Calcium channels and Calcium-regulated channels in human red blood cells -- Regulation of multifunctional calcium/calmodulin stimulated protein kinases by molecular targeting -- Widespread roles of CaMK-II in Developmental Pathways -- Readily releasable stores of calcium in neuronal endolysosomes: Physiological and pathophysiological relevance -- At the crossing of ER stress and MAMs: A key role of Sigma-1 receptor?- ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases -- The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells -- Calcium Signaling and Gene Expression -- Simulation Strategies for Calcium Microdomains and Calcium Noise -- A statistical view on calcium oscillations -- Calcium Regulation of Bacterial Virulence -- Ca2+ Signaling in Drosophila Photoreceptor Cells -- Calcium imaging in Drosophila melanogaster -- Calcium imaging in the zebrafish -- Stimulation-secretion coupling in the beta cells: from basic to bedside -- Calcium dynamics and synaptic plasticity -- Calcium signaling during brain aging and its influence on the hippocampal synaptic plasticity -- Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease -- Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR) -- Extracellular Ca2+ in bone marrow -- Calcium in Cell-Extracellular Matrix Interactions -- Index.
    Abstract: This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XIII, 1110 p. 150 illus., 132 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030124571
    Series Statement: Advances in Experimental Medicine and Biology, 1131
    DDC: 612.8
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medicine Research. ; Biology Research. ; Proteins . ; Biology Technique. ; Neuroscience. ; Biomedical Research. ; Protein Biochemistry. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Peroxisome: metabolic functions and biogenesis -- Chapter 2. Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk -- Chapter 3. 7-hydroxycholesterols-induced peroxisomal disorders in glial and microglial cells: potential role in neurodegeneration -- Chapter 4. Peroxisome biogenesis disorders -- Chapter 5. Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk with Other Organelles And Peroxisomal Disorders -- Chapter 6. Zellweger syndrome disorders: from severe neonatal disease to atypical adult presentation -- Chapter 7. Heimler Syndrome -- Chapter 8. Potential involvement of peroxisome in multiple sclerosis and Alzheimer’s disease -- Chapter 9. Developmental and degenerative cerebellar pathologies in peroxisomal β-oxidation deficiency -- Chapter 10. A mouse model system to study peroxisomal role in neurodegenerative diseases such as peroxisome biogenesis disorders -- Chapter 11. The Drosophila melanogaster as genetic model system to dissect the mechanisms of disease that lead to neurodegeneration in adrenoleukodystrophy -- Chapter 12. Human peroxisomal 3-keto-acyl-CoA thiolase: tissue expression and metabolic regulation -- Chapter 13. Biological functions of plasmalogens -- Chapter 14. Therapeutic efficacy of plasmalogens for Alzheimer’s disease, Mild Cognitive Impairment and Parkinson’s disease in conjunction with a new hypothesis for the etiology of Alzheimer’s disease.
    Abstract: This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.
    Type of Medium: Online Resource
    Pages: X, 212 p. 44 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030602048
    Series Statement: Advances in Experimental Medicine and Biology, 1299
    DDC: 612.8
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medical genetics. ; Neuroscience. ; Medical Genetics.
    Description / Table of Contents: In Silico and In Vivo Studies on Quercetin as Potential Anti- Parkinson Agent -- Exhaled Breath Condensate (EBC). Is it a viable source of biomarkers for lung diseases? -- Treatment development for Alzheimer's disease: how are we doing? -- Microbiome hijacking towards an integrative pest management pipeline -- Regulation and roles of autophagy in the brain -- Three-dimensional models for studying neurodegenerative and neurodevelopmental diseases -- Assessment of factors contributing to the enhancement of memory and cognitive abilities in the context of neurosciences -- Buccal Mucosa Biomarkers in Alzheimer’s Disease -- Engaging social interest and creating awareness for the behavioural and psychological symptoms of dementia -- Structural study of the DNA – Clock/Bmal1 complex provides insights for the role of cortisol, hGR and HPA axis in stress management and sleep disorders -- The Effects of Quantum Entanglement on Chromatin and Gene Expression -- Olive Oil Polyphenols in Neurodegenerative Pathologies -- Human pluripotent stem cells as in vitro models of neurodegenerative diseases -- Nutritional Lipidomics in Alzheimer's Disease -- Alzeheimer’s Disease Therapeutic Approaches -- Stress and Wellbeing of Psychiatry Trainees: A Literature Review -- Brief Cognitive Tests in the case of Dementia and Alzheimer’s Disease Early Diagnosis -- Synthesis, Molecular Docking studies and Biological Evaluation of N-Acylarylhydrazones as Anti-inflammatory agents -- Exosome biomarkers revolutionize preclinical diagnosis of neurodegenerative diseases and assessment of treatment responses in clinical trials -- Biomarkers as a different approach in prevention and treatment of drug addiction (preliminary study) -- Sleep disorders and Restless Leg Syndrome in hemodialysis patients in Greece: a cross-sectional study -- Craniofacial and neurological phenotype in a patient with de novo 18q microdeletion and 18p microduplication -- What do recent clinical trials teach us about the etiology of AD -- Developmental Biology and Transgenic Avian Embryology: Body Alterity Bioart Wet Lab -- Gene editing, sexual reproduction and the arts: the present, the future and the imagined -- Amyotrophic Lateral Sclerosis: Current status in diagnostic biomarkers -- Synthesis and Characterization of Biologically Significant, 5-[N,N-dialkylamino alkoxy] azaindole 2-one,3- thiosemicarbazones and 5-[N,N-dialkylamino alkoxy] azaindole 3-hydrazone, 2-ones -- Genetic counseling for adult-onset spinal and bulbar muscular atrophy (Kennedy syndrome). Multiple cases of prenatal testing in a family -- Transcriptomics and Metabolomics in Amyotrophic Lateral Sclerosis -- Ocimum Sanctum Linn: A Potential Adjunct Therapy for Hyperhomocysteinemia – Induced Vascular Dementia -- Alzheimer's disease: The role of mutations in protein folding.
    Abstract: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people. .
    Type of Medium: Online Resource
    Pages: XII, 262 p. 42 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030326333
    Series Statement: Advances in Experimental Medicine and Biology, 1195
    DDC: 612.8
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Psychobiology. ; Human behavior. ; Physical anthropology. ; Cognitive psychology. ; Animal welfare Moral and ethical aspects. ; Animal migration. ; Animal culture. ; Behavioral Neuroscience. ; Physical-Biological Anthropology. ; Cognitive Psychology. ; Animal Ethics. ; Animal Migration. ; Animal Science.
    Description / Table of Contents: Part I: Introduction -- Chapter 1: Recent developments in primatology and their relevance to the study of Tibetan macaques -- Part II: Social Behavior and Dynamics in Tibetan Macaques -- Chapter 2: Social and Life History Strategies of Tibetan Macaques at Mt. Huangshan -- Chapter 3: Size Matters in Primate Societies: How Social Mobility Relates to Social Stability in Tibetan and Japanese Macaques -- Chapter 4: Behavioral exchange and interchange as strategies to facilitate social relationships in Tibetan macaques -- Chapter 5: Social relationships impact collective decision-making in Tibetan macaques -- Chapter 6: Considering Social Play in Primates: A Case Study in Juvenile Tibetan Macaques (Macacathibetana) -- Chapter 7: The Vocal Repertoire of Tibetan Macaques (Macacathibetana) and Congeneric Comparisons -- Chapter 8: Tibetan Macaque Social Style: Co-variant and Quasi-independent Evolution -- Part III: Evolution of Rituals: Insights from Bridging Behavior -- Chapter 9: Preliminary observations of female-female bridging behavior in Tibetan macaques (Macacathibetana) at Mt. Huangshan, China -- Chapter 10: Bridging Behavior and Male-Infant Interactions in Macacathibetana and M. assamensis: Insight into the Evolution of Social Behavior in the sinica Species-group of Macaques -- Part IV: Livingwith Microbes, Parasites, and Diseases -- Chapter 11: The gut microbiome of Tibetan macaques: composition, influencing factors and function in feeding ecology -- Chapter 12: Medicinal Properties in the Diet of Tibetan Macaques at Mt. Huangshan - A Case for Self-medication -- Chapter 13: Primate infectious disease ecology: Insights and future directions at the human-macaque interface -- Part V: Emerging Technologies in Primatology -- Chapter 14: High field MRI technology for behavioral and cognitive studies in macaques in vivo.
    Abstract: This open access book summarizes the multi-disciplinary results of one of China’s main primatological research projects on the endemic Tibetan macaque (Macaca thibetana), which had continued for over 30 years, but which had never been reported on systematically. Dedicated to this exceptional Old World monkey, this book makes the work of Chinese primatologists on the social behavior, cooperation, culture, cognition, group dynamics, and emerging technologies in primate research accessible to the international scientific community. One of the most impressive Asian monkeys, and the largest member of its genus, the Tibetan macaque deserves to be better known. This volume goes a long way towards bringing this species into the spotlight with many excellent behavioral analyses from the field.- Frans de Waal, Professor of Psychology, Emory University, USA. Macaques matter. To understand primate patterns and trends, and to gain important insight into humanity, we need to augment and expand our engagement with the most successful and widespread primate genus aside from Homo. This volume focuses on the Tibetan macaque, a fascinating species with much to tell us about social behavior, physiology, complexity and the macaque knack for interfacing with humans. This book is doubly important for primatology in that beyond containing core information on this macaque species, it also reflects an effective integrated collaboration between Chinese scholars and a range of international colleagues—exactly the type of collaborative engagement primatology needs. This volume is a critical contribution to a global primatology. - Agustín Fuentes, Professor of Anthropology, University of Notre Dame, USA. I have many fond memories of my association with Mt. Huangshan research beginning in 1983, when together with Professor Qishan Wang we established this site. It is such a beautiful place and I miss it. It is gratifying to see how far research has progressed since we began work there, becoming more internationalized and very much a collaborative endeavor under the long-term direction of Professor Jin-Hua Li and colleagues. This book highlights the increased interest in this species, representing a variety of disciplines ranging from macro aspects of behavior, cognition and sociality, to micro aspects of microbes, parasites and disease, authored by a group of renowned Chinese and international primatologists. I applaud their efforts and expect more interesting work to come from this site in the years ahead.- Kazuo Wada, Professor Emeritus, Kyoto University, Japan.
    Type of Medium: Online Resource
    Pages: XVI, 302 p. 93 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030279202
    Series Statement: Fascinating Life Sciences,
    DDC: 612.8
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Immunology. ; Psychiatry. ; Neuroscience. ; Immunology. ; Psychiatry.
    Description / Table of Contents: Preface -- A Brief History of Immunological Research into Psychosis and Pathways for Immune Influence of the Brain.-Basic Concept of Microglia Biology and Neuroinflammation in Relation to Psychiatry -- Epidemiological Studies of Prenatal and Childhood Infection and Schizophrenia -- Schizophrenia, Cytokines and Other Systemic Inflammatory Mediators [to include oxidative stress and lymphocyte alterations] -- Association between Schizophrenia, Microbial Infection and Microbiota -- Autoantibodies and psychosis -- Effect of Infection on Cognition in Schizophrenia and Healthy People -- Role of Infection, Autoimmunity, Atopic Disorders and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies -- Microglial Activation and Psychotic Disorders: Evidence from Pre-clinical and Clinical Studies -- Early-Life Adversity, Systemic Inflammation, and Co-Morbid Physical and Psychiatric Illnesses of Adult Life -- Inflammation, Antipsychotic Drugs and Evidence for Effectiveness of Anti-inflammatory Agents in Schizophrenia.
    Abstract: This book provides a comprehensive summary of the cutting edge scientific evidence regarding the role of immune system in the pathogenesis and treatment of schizophrenia and related psychotic disorders. It illustrates the role of inflammation and immunity in schizophrenia drawing on both basic science and clinical research. The chapters provide up-to-date summaries of immunological risk factors for schizophrenia and related psychotic disorders, and underlying mechanisms as informed by neuroimaging, genetic, clinical and animal experimental studies. In addition, the book will illuminate the scope for immunological treatment for schizophrenia. .
    Type of Medium: Online Resource
    Pages: X, 244 p. 10 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030391416
    Series Statement: Current Topics in Behavioral Neurosciences, 44
    DDC: 612.8
    Language: English
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    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Veterinary medicine. ; Neurology . ; Anatomy. ; Neuroscience. ; Veterinary Science. ; Neurology. ; Anatomy.
    Description / Table of Contents: Introduction -- Rodent Taxonomic and biological data -- Basic Neurohistology -- Basic Neuroanatomy/ Coverings of the CNS/ Cerebrospinal fluid system -- Microscopic anatomy of the mouse brain -- The mouse spinal cord -- The mouse brainstem -- The mouse cerebellum -- The mouse dorsal thalamus -- The mouse hypothalamus.-The mouse cerebral cortex.-The mouse hippocampus.-The mouse amygdala -- The mouse caudate putamen -- The mouse oflactory system -- The mouse circle of Willis.
    Abstract: This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories. .
    Type of Medium: Online Resource
    Pages: XI, 350 p. 269 illus., 241 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030198985
    DDC: 612.8
    Language: English
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  • 97
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Psychiatry. ; Psychobiology. ; Human behavior. ; Psychology, Experimental. ; Neuroscience. ; Psychiatry. ; Behavioral Neuroscience. ; Biological Psychology. ; Experimental Psychology.
    Description / Table of Contents: Overview chapter -- Imaging studies linking dopaminergic systems to impulsivity in humans -- The Genetics of Externalizing Problems -- The neuropharmacology of impulsive behaviour: ten years later -- Inhibitory control and impulsivity in childhood onset disruptive behavior disorders -- Steep discounting of future rewards as an impulsivity phenotype: a concise review -- Developmental considerations in impulsivity: Implications for research and treatment -- Reinforcer Pathology: Implications for Substance Abuse Intervention -- Impulsivity and Suicidal Behavior -- Sex differences in neural circuits underlying inhibitory control -- The role of impulsivity facets on the incidence and development of alcohol use disorders -- The neurobiology of reinforcement learning mechanisms in impulsivity.
    Abstract: This volume provides an empirical and conceptual overview of advances in our understanding of impulsivity and impulsive behaviors. Prominent scientists review the range of behavioral phenomena referred to as ‘impulsive’, as well as the defining features and psychological, neurocognitive and behavioral processes that underlie of the manifestation of impulsive behaviors, focussing on progress made and the questions remaining to be answered.
    Type of Medium: Online Resource
    Pages: VIII, 221 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030605117
    Series Statement: Current Topics in Behavioral Neurosciences, 47
    DDC: 612.8
    Language: English
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  • 98
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neurology . ; Anatomy. ; Neuroscience. ; Neurology. ; Anatomy.
    Description / Table of Contents: Overview of the Human Brain and Spinal Cord -- Vascularization of the Brain and Spinal Cord -- Notes on Techniques -- The Somatosensory System -- The Reticular Formation and the Neuromodulatory Systems -- The Cranial Nerves -- The Auditory System -- The Visual System -- Motor Systems -- The Cerebellum -- The Basal Ganglia -- The Autonomic Nervous System -- The Hypothalamus, the Preoptic Area and Hypothalamohypophysial Systems -- The Limbic System -- The Cerebral Cortex and Complex Cerebral Functions.
    Abstract: Connections define the functions of neurons: information flows along connections, as well as growth factors and viruses, and even neuronal death can progress through connections. Accordingly, knowing how the various parts of the brain are interconnected to form functional systems is a prerequisite for properly understanding data from all fields in the neurosciences. Clinical Neuroanatomy: Brain Circuitry and Its Disorders bridges the gap between neuroanatomy and clinical neurology. It focuses on human and primate data in the context of brain circuitry disorders, which are so common in neurological practice. In addition, numerous clinical cases are presented to demonstrate how normal brain circuitry can be interrupted, and what the effects are. Following an introduction to the organization and vascularization of the human brain and the techniques used to study brain circuitry, the main neurofunctional systems are discussed, including the somatosensory, auditory, visual, motor, autonomic and limbic systems, the cerebral cortex and complex cerebral functions. In this 2nd edition, apart from a general updating, many new illustrations have been added and more emphasis is placed on modern techniques such as diffusion magnetic resonance imaging (dMRI) and network analysis. Moreover, a developmental ontology based on the prosomeric model is applied, resulting in a more modern subdivision of the brain. The new edition of Clinical Neuroanatomy is primarily intended for neurologists, neuroradiologists and neuropathologists, as well as residents in these fields, but will also appeal to (neuro)anatomists and all those whose work involves human brain mapping.
    Type of Medium: Online Resource
    Pages: XVI, 981 p. 509 illus., 325 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030418786
    DDC: 612.8
    Language: English
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