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  • Books  (3)
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  • English  (3)
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  • 2020-2024  (3)
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  • 1
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Neurosciences. ; Medicine Research. ; Biology Research. ; Psychology. ; Neuroscience. ; Biomedical Research. ; Behavioral Sciences and Psychology.
    Description / Table of Contents: Chapter 1: Neural Circuits Underlying Innate Fear -- Chapter 2: Neurobiology and Neural Circuits of Aggression -- Chapter 3: Neural Regulation of Feeding Behavior -- Chapter 4: Neural Circuits for Reward -- Chapter 5: Neuronal response and behavioral modulation in social interaction -- Chapter 6: Neural circuit mechanisms that underlie parental care -- Chapter 7: Spatial navigation -- Chapter 8: Neural circuits for sleep-wake regulation.
    Abstract: This book summarizes the latest research findings in the neurocircuitry of innate behaviors, covering major topics such as innate fear, aggression, feeding, reward, social interaction, parental care, spatial navigation, and sleep-wake regulation. For decades, humans have been fascinated by wild animals’ instincts, like the annual two-thousand-mile migration of the monarch butterfly in North American, and the “imprint” behavior of newborn birds. Since these instincts are always displayed in stereotypical patterns in most individuals of a given species, the neural circuits processing such behaviors must be genetically hard-wired in the brain. Recently, with the development of modern techniques, including optogenetics, retrograde and anterograde virus tracing, and in vivo calcium imaging, researchers have been able to determine and dissect the specific neural circuits for many innate behaviors by selectively manipulating well-defined cell types in the brain. This book discusses recent advances in the investigation of the neural-circuit mechanisms underlying innate behaviors.
    Type of Medium: Online Resource
    Pages: IX, 112 p. 13 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811570865
    Series Statement: Advances in Experimental Medicine and Biology, 1284
    DDC: 612.8
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medicine Research. ; Biology Research. ; Proteins . ; Biology Technique. ; Neuroscience. ; Biomedical Research. ; Protein Biochemistry. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Peroxisome: metabolic functions and biogenesis -- Chapter 2. Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk -- Chapter 3. 7-hydroxycholesterols-induced peroxisomal disorders in glial and microglial cells: potential role in neurodegeneration -- Chapter 4. Peroxisome biogenesis disorders -- Chapter 5. Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk with Other Organelles And Peroxisomal Disorders -- Chapter 6. Zellweger syndrome disorders: from severe neonatal disease to atypical adult presentation -- Chapter 7. Heimler Syndrome -- Chapter 8. Potential involvement of peroxisome in multiple sclerosis and Alzheimer’s disease -- Chapter 9. Developmental and degenerative cerebellar pathologies in peroxisomal β-oxidation deficiency -- Chapter 10. A mouse model system to study peroxisomal role in neurodegenerative diseases such as peroxisome biogenesis disorders -- Chapter 11. The Drosophila melanogaster as genetic model system to dissect the mechanisms of disease that lead to neurodegeneration in adrenoleukodystrophy -- Chapter 12. Human peroxisomal 3-keto-acyl-CoA thiolase: tissue expression and metabolic regulation -- Chapter 13. Biological functions of plasmalogens -- Chapter 14. Therapeutic efficacy of plasmalogens for Alzheimer’s disease, Mild Cognitive Impairment and Parkinson’s disease in conjunction with a new hypothesis for the etiology of Alzheimer’s disease.
    Abstract: This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.
    Type of Medium: Online Resource
    Pages: X, 212 p. 44 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030602048
    Series Statement: Advances in Experimental Medicine and Biology, 1299
    DDC: 612.8
    Language: English
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  • 3
    Keywords: Neurosciences. ; Pharmacology. ; Medicine Research. ; Biology Research. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Pharmacology. ; Biomedical Research. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: 1.Determination of ketamine in the river of China -- 2.Ketamine abuse in Taiwan -- 3.Ketamine problem in Hong Kong -- 4. Hair analysis of ketamine -- 5. Brain imaging of ketamine abusers -- 6.Management of complications of ketamine abuse -- 7.Action site of ketamine in the NMDA receptor channel -- 8.Synaptic modulation in the effect of ketamine -- 9.Rodents whole-brain imaging in the effects of ketamine -- 10. Behavioral pharmacology of ketamine: An overview of preclinical studies -- 11.Antidepressant potential of ketamine enantiomers -- 12.Effects of ketamine on pain-related depression -- 13.Role of gut microbiota in the antidepressant actions of ketamine and its enantiomers -- 14. The role of NMDA receptor GluN2D subunit in the effects of ketamine and enantiomers -- 15.Roles of the lateral habenula in the actions of ketamine -- 16.Comparison of antidepressant action of ketamine and group II mGlu receptor antagonists -- 17.Antidepressant effects of ketamine in Taiwanese patients with treatment-resistant depression.
    Abstract: This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants. .
    Type of Medium: Online Resource
    Pages: V, 189 p. 27 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811529023
    DDC: 612.8
    Language: English
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