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  • Books  (5)
  • Biomedical Research.  (5)
  • English  (5)
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  • 2005-2009
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  • 2020  (5)
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  • 612.8  (3)
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  • Books  (5)
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  • English  (5)
  • German
  • Polish
  • Swedish
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  • 2020-2024  (5)
  • 2010-2014
  • 2005-2009
  • 1985-1989
  • 1950-1954
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  • 1
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Neurosciences. ; Medicine Research. ; Biology Research. ; Psychology. ; Neuroscience. ; Biomedical Research. ; Behavioral Sciences and Psychology.
    Description / Table of Contents: Chapter 1: Neural Circuits Underlying Innate Fear -- Chapter 2: Neurobiology and Neural Circuits of Aggression -- Chapter 3: Neural Regulation of Feeding Behavior -- Chapter 4: Neural Circuits for Reward -- Chapter 5: Neuronal response and behavioral modulation in social interaction -- Chapter 6: Neural circuit mechanisms that underlie parental care -- Chapter 7: Spatial navigation -- Chapter 8: Neural circuits for sleep-wake regulation.
    Abstract: This book summarizes the latest research findings in the neurocircuitry of innate behaviors, covering major topics such as innate fear, aggression, feeding, reward, social interaction, parental care, spatial navigation, and sleep-wake regulation. For decades, humans have been fascinated by wild animals’ instincts, like the annual two-thousand-mile migration of the monarch butterfly in North American, and the “imprint” behavior of newborn birds. Since these instincts are always displayed in stereotypical patterns in most individuals of a given species, the neural circuits processing such behaviors must be genetically hard-wired in the brain. Recently, with the development of modern techniques, including optogenetics, retrograde and anterograde virus tracing, and in vivo calcium imaging, researchers have been able to determine and dissect the specific neural circuits for many innate behaviors by selectively manipulating well-defined cell types in the brain. This book discusses recent advances in the investigation of the neural-circuit mechanisms underlying innate behaviors.
    Type of Medium: Online Resource
    Pages: IX, 112 p. 13 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811570865
    Series Statement: Advances in Experimental Medicine and Biology, 1284
    DDC: 612.8
    Language: English
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  • 2
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmaceutical chemistry. ; Medicine Research. ; Biology Research. ; Spectrum analysis. ; Separation (Technology). ; Pharmaceutics. ; Biomedical Research. ; Spectroscopy. ; Separation Science.
    Description / Table of Contents: Part 1. Spectrophotometric techniques -- Chapter 1. Introduction of pharmaceutical analysis -- Chapter 2. Introduction of spectrophotometric techniques -- Chapter 3. UV-VIS spectroscopy -- Chapter 4. Infra-Red spectroscopy -- Chapter 5. Atomic spectroscopy -- Chapter 6. Atomic absorption spectroscopy -- Chapter 7. Atomic Emission spectroscopy -- Chapter 9. Mass spectroscopy -- Chapter 10. Nuclear magnetic resonance spectroscopy -- Part 2. Chromatographic techniques -- Chapter 11. Introduction of chromatographic techniques -- Chapter 12. Thin layer chromatography -- Chapter 13. Colum chromatography -- Chapter 14. High performance liquid chromatography (HPLC) -- Chapter 15. Gas chromatography -- Part 3. Thermal analysis techniques -- Chapter 16. Introduction of thermal analysis -- Chapter 17. Differential scanning calorimetry (DSC) -- Chapter 18. Differential thermal analysis (DTA) -- Chapter 19. Thermo gravimetric analysis (TGA).
    Abstract: Recent advances in the pharmaceutical sciences and biotechnology have facilitated the production, design, formulation and use of various types of pharmaceuticals and biopharmaceuticals. This book provides detailed information on the background, basic principles, and components of techniques used for the analysis of pharmaceuticals and biopharmaceuticals. Focusing on those analytical techniques that are most frequently used for pharmaceuticals, it classifies them into three major sections and 19 chapters, each of which discusses a respective technique in detail. Chiefly intended for graduate students in the pharmaceutical sciences, the book will familiarize them with the components, working principles and practical applications of these indispensable analytical techniques.
    Type of Medium: Online Resource
    Pages: XVII, 222 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811515477
    DDC: 615.19
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmaceutical chemistry. ; Medicine Research. ; Biology Research. ; Medical sciences. ; Biomaterials. ; Biology Technique. ; Pharmaceutics. ; Biomedical Research. ; Health Sciences. ; Biomaterials. ; Biological Techniques.
    Description / Table of Contents: Preface -- Part I: Fundamentals of Systemic Delivery -- Anti-aging medicine: new concepts and intervention development,- Roles of systemic delivery in the development of anti-aging therapies -- Pharmacokinetics and pharmacodynamics in drug delivery -- Physiological, biochemical, and chemical barriers to systemic delivery -- Partt II: Development of Delivery Technologies for Systemic Delivery -- Use of prodrugs for systemic delivery in anti-aging medicine -- Use of physical methods for systemic delivery in anti-aging medicine -- Use of viral systems for systemic delivery in anti-aging medicine -- Use of non-viral biological systems for systemic delivery in anti-aging medicine -- Use of lipid-based systems for systemic delivery in anti-aging medicine -- Use of polymeric systems for systemic delivery in anti-aging medicine -- Use of inorganic nanoparticles for systemic delivery in anti-aging medicine -- Part III: Practical Considerations in Intervention Execution -- Strategies in carrier design to enhance systemic delivery -- Characterization techniques for studying the properties of the carriers -- In vivo assessment of the efficiency of systemic delivery in anti-aging medicine -- Selection of administration routes for systemic delivery in anti-aging medicine -- Intellectual property and regulatory issues in drug delivery research -- Index.
    Abstract: This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.
    Type of Medium: Online Resource
    Pages: XVI, 511 p. 128 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030544904
    Series Statement: Healthy Ageing and Longevity, 13
    DDC: 615.19
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medicine Research. ; Biology Research. ; Proteins . ; Biology Technique. ; Neuroscience. ; Biomedical Research. ; Protein Biochemistry. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Peroxisome: metabolic functions and biogenesis -- Chapter 2. Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk -- Chapter 3. 7-hydroxycholesterols-induced peroxisomal disorders in glial and microglial cells: potential role in neurodegeneration -- Chapter 4. Peroxisome biogenesis disorders -- Chapter 5. Fatty Acid Oxidation in Peroxisomes: Enzymology, Metabolic Crosstalk with Other Organelles And Peroxisomal Disorders -- Chapter 6. Zellweger syndrome disorders: from severe neonatal disease to atypical adult presentation -- Chapter 7. Heimler Syndrome -- Chapter 8. Potential involvement of peroxisome in multiple sclerosis and Alzheimer’s disease -- Chapter 9. Developmental and degenerative cerebellar pathologies in peroxisomal β-oxidation deficiency -- Chapter 10. A mouse model system to study peroxisomal role in neurodegenerative diseases such as peroxisome biogenesis disorders -- Chapter 11. The Drosophila melanogaster as genetic model system to dissect the mechanisms of disease that lead to neurodegeneration in adrenoleukodystrophy -- Chapter 12. Human peroxisomal 3-keto-acyl-CoA thiolase: tissue expression and metabolic regulation -- Chapter 13. Biological functions of plasmalogens -- Chapter 14. Therapeutic efficacy of plasmalogens for Alzheimer’s disease, Mild Cognitive Impairment and Parkinson’s disease in conjunction with a new hypothesis for the etiology of Alzheimer’s disease.
    Abstract: This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.
    Type of Medium: Online Resource
    Pages: X, 212 p. 44 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030602048
    Series Statement: Advances in Experimental Medicine and Biology, 1299
    DDC: 612.8
    Language: English
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  • 5
    Keywords: Neurosciences. ; Pharmacology. ; Medicine Research. ; Biology Research. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Pharmacology. ; Biomedical Research. ; Neuropsychology. ; Neurology.
    Description / Table of Contents: 1.Determination of ketamine in the river of China -- 2.Ketamine abuse in Taiwan -- 3.Ketamine problem in Hong Kong -- 4. Hair analysis of ketamine -- 5. Brain imaging of ketamine abusers -- 6.Management of complications of ketamine abuse -- 7.Action site of ketamine in the NMDA receptor channel -- 8.Synaptic modulation in the effect of ketamine -- 9.Rodents whole-brain imaging in the effects of ketamine -- 10. Behavioral pharmacology of ketamine: An overview of preclinical studies -- 11.Antidepressant potential of ketamine enantiomers -- 12.Effects of ketamine on pain-related depression -- 13.Role of gut microbiota in the antidepressant actions of ketamine and its enantiomers -- 14. The role of NMDA receptor GluN2D subunit in the effects of ketamine and enantiomers -- 15.Roles of the lateral habenula in the actions of ketamine -- 16.Comparison of antidepressant action of ketamine and group II mGlu receptor antagonists -- 17.Antidepressant effects of ketamine in Taiwanese patients with treatment-resistant depression.
    Abstract: This book presents the latest data from basic research and clinical trials supporting the effectiveness of ketamine as a treatment for depression, bipolar disorder, and suicidal behavior, setting these positive findings within the context of the serious problem of ketamine abuse. The first part of the book focuses on the evidence regarding ketamine abuse, with specific reference to Asian countries, and discusses countermeasures and complication management. It then addresses the mechanisms underlying the antidepressant and side effects of ketamine, which have remained elusive, describing and discussing important new research findings. Further, it explains insights gained from whole brain imaging in rodents and from behavioral pharmacology, and presents evidence regarding the role of gut microbiota, the NMDA receptor GluN2D subunit, and the lateral habenula in the actions of ketamine. These advances form the basis for the safer use of ketamine in patients with treatment-resistant depression and are expected to lead to the development of new antidepressants. .
    Type of Medium: Online Resource
    Pages: V, 189 p. 27 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811529023
    DDC: 612.8
    Language: English
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