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  • 1
    Keywords: Human physiology. ; Medicine Research. ; Biology Research. ; Proteins . ; Biological transport. ; Cell membranes. ; Human Physiology. ; Biomedical Research. ; Protein Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells -- 2. Na+-K+-2Cl- Cotransporter -- 3. Thiazide-sensitive NaCl Cotransporter -- 4. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia -- 5. Na+/H+ Exchangers in Epithelia -- 6. Sugar Transport Across Epithelia -- 7. Amino Acid Transporters of Epithelia -- 8. Structure-Dynamic and Regulatory Specificities of Epithelial Na+/Ca2+ Exchangers (NCX) -- 9. Urea Transporters in Health and Disease -- 10. H,K-ATPases in Epithelia -- 11. Zinc Transporters Involved in Vectorial Zinc Transport in Intestinal Epithelial Cells -- 12. Properties, Structure and Function of the Solute Carrier 26 Family of Anion Transporters -- 13. ClC-2 Chloride Channels -- 14. The Role of the Endosomal Chloride/Proton Antiporter ClC-5 in Proximal Tubule Endocytosis and Kidney Physiology -- 15. CFTR and Cystic Fibrosis: A Need for Personalized Medicine -- 16. Molecular Physiology and Pharmacology of the Cystic Fibrosis Transmembrane Conductance Regulator -- 17. TMEM16 Proteins (Anoctamins) in Epithelia -- 18. Epithelial Sodium Channels (ENaC) -- 19. ROMK and Bartter Syndrome Type 2 -- 20. Inwardly-rectifying K+ channel 4.1 regulates renal K+ excretion in the aldosterone-sensitive distal nephron -- 21. Small-molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels -- 22. KCa3.1 in Epithelia -- 23. BK Channels in Epithelia -- 24. Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ channels -- 25. KCNE regulation of KCNQ channels -- 26. Orai Channels -- 27. Trp Channels in Renal Epithelia -- 28. P2X receptors in Epithelia -- 29. The Polycystins and Polycystic Kidney Disease -- 30. Renal Aquaporins in Health and Disease.
    Abstract: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.
    Type of Medium: Online Resource
    Pages: XXI, 1244 p. 256 illus., 203 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030554545
    Series Statement: Physiology in Health and Disease,
    DDC: 612
    Language: English
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  • 2
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Urology. ; Biophysics. ; Human Physiology. ; Urology. ; Bioanalysis and Bioimaging.
    Description / Table of Contents: Introduction of human sperm ultrastructural morphology -- Ultrastructural morphology of human sperm head -- Ultrastructural morphology of human sperm neck -- Ultrastructural morphology of human sperm middle piece -- Ultrastructural morphology of human sperm principal piece -- Ultrastructural morphology of human sperm terminal piece -- Ultrastructural morphological measurement of human sperm -- Artefacts of human sperm ultrastructural morphology -- Phenomena related to inadequate preparation of human sperm.
    Abstract: This atlas provides ultrastructural morphological images of human spermatozoa. Sperm morphology plays an essential role in sperm-oocyte interactions and early embryonic development, and human sperm ultrastructural morphology offers a valuable reference tool for assessing certain etiologies of male infertility and reproductive failure. However, the ultrastructural morphology of human sperm has not been systematically evaluated or thoroughly described in the literature. Using 470 original and unpublished images, the book shows various ultrastructural morphological phenotypes; defects of the sperm head, neck, middle piece, principal piece, and terminal piece; as well as artifacts of sperm ultrastructural morphology and phenomena related to inadequate preparation, demonstrating several sperm phenotypes and surface structural appearances for the first time. As such, it helps researchers and practitioners in andrology, reproductive medicine, and reproductive pathology gain a better understanding of human sperm ultrastructural morphology.
    Type of Medium: Online Resource
    Pages: XIII, 276 p. 370 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811553257
    DDC: 612
    Language: English
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  • 3
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Sports sciences. ; Medicine, Preventive. ; Health promotion. ; Human Physiology. ; Sport Science. ; Health Promotion and Disease Prevention.
    Description / Table of Contents: Chapter 1. An overview of the beneficial effects of exercise on health and performance -- Chapter 2. Type of exercise training and training methods -- Chapter 3. Molecular mechanisms mediating adaptation to exercise -- Chapter 4. Exercise and organ crosstalk -- Chapter 5. Exercise and Hyperlipidemia -- Chapter 6. Exercise and Type 2 diabetes -- Chapter 7. Exercise and Type 1 Diabetes -- Chapter 8. Exercise and Polycystic ovarian syndrome -- Chapter 9. Exercise and insulin resistance -- Chapter 10. Exercise and Hypertension -- Chapter 11. Exercise and Coronary heart disease -- Chapter 12. Exercise and Peripheral Arteriosclerosis -- Chapter 13. Exercise and Stroke -- Chapter 14. Exercise and cardiovascular protection -- Chapter 15. Exercise and Osteoarthritis -- Chapter 16. Exercise and Chronic Pain -- Chapter 17. Exercise and muscle atrophy -- Chapter 18. Exercise and Depressive disorder -- Chapter 19. Exercise and Parkinson’s disease -- Chapter 20. Exercise and Dementia -- Chapter 21. Exercise and Schizophrenia -- Chapter 22. Exercise and Multiple Sclerosis -- Chapter 23. Exercise and anxiety -- Chapter 24. Exercise and Chronic obstructive pulmonary disease (COPD) -- Chapter 25. Exercise and Asthma -- Chapter 26. Exercise and Cystic fibrosis -- Chapter 27. Exercise regulates the immune system -- Chapter 28. Effects of Exercise on the immune function, quality of life and mental health in HIV/AIDS individuals -- Chapter 29. Effects of Exercise on Memory Interference in Neuropsychiatric Disorders -- Chapter 30. Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders -- Chapter 31. Prospective advances in beneficial effects of exercise on human health.
    Abstract: This book shares the latest findings on exercise and its benefits in preventing and ameliorating numerous diseases that are of worldwide concern. Addressing the role of exercise training as an effective method for the prevention and treatment of various disease, the book is divided into eleven parts: 1) An Overview of the Beneficial Effects of Exercise on Health and Performance, 2) The Physiological Responses to Exercise, 3) Exercise and Metabolic Diseases, 4) Exercise and Cardiovascular Diseases, 5) Exercise and Musculoskeletal Diseases, 6) Exercise and Neurological and Psychiatric Diseases, 7) Exercise and the Respiration System, 8) Exercise and Immunity, 9) Exercise and HIV/AIDS, 10) Exercise and Neuropsychiatric Disorders, and 11) Future Prospects. Given its scope, the book will be particularly useful for researchers and students in the fields of physical therapy, physiology, medicine, genetics and cell biology, as well as researchers and physicians with a range of medical specialties.
    Type of Medium: Online Resource
    Pages: IX, 459 p. 12 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811517921
    Series Statement: Advances in Experimental Medicine and Biology, 1228
    DDC: 612
    Language: English
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  • 4
    Keywords: Human physiology. ; Human Physiology.
    Description / Table of Contents: Prevalence, consequences, causes and management of obesity -- Adipocytes Under Environmental Assault: Targets for Obesity? -- Obesity and its Complications Pathogenesis -- Extracellular Vesicles and Circulating miRNAs - Exercise -Induced Mitigation of Obesity and Associated Metabolic Diseases -- Pathophysiology of Obesity Induced Hyperglycemia and Insulin Resistance -- Obesity and Osteoarthritis: Are Adipokines Bridging Metabolism, Inflammation, and Biomechanics -- Understanding the Initiation and Progression of Diet-Induced Obesity and Associated Pathophysiology: Lessons Learned from a Rat Model -- Immune Modulation and Macrophage Polarization in Pathogenesis of Pancreatic Dysfunction in Obesity -- Association Between Obesity and Poor Sleep: A Review of Epidemiological Evidence -- Exploration of the Bidirectionality of Obesity and Depression by means of the Neuropsychological Model of Obesity Genesis -- Obesity-Induced Non-Alcoholic Fatty Liver Disease (NAFLD): role of hyperhomocystenemia -- Mechanisms of Obesity Related Kidney Disease -- Consequences of Maternal Obesity on Neonatal Outcomes and Cardio-Metabolic Health in Infancy -- The Developmental Mechanisms of Obesity by Maternal Obesity -- Diet Induced Maternal Hypercholesterolemia and In Utero Fetal Programming -- Modified Denouement in Bariatric Surgery due to Genetic Polymorphism -- Anti-Inflammatory Components from Functional Foods for Obesity -- Attenuation of Obesity-Associated Oxidative Stress by Cucurbita maxima Seed Oil in High Fat Diet Induced Obese Rats -- Pathophysiology of Obesity-Related Non-Communicable Chronic Diseases and Advancements in Preventive Strategies.
    Abstract: According to the World Health Organization, the epidemic of global obesity has nearly tripled since 1975. In 2016, more than 1.9 billion adults were overweight, over 650 million of which were obese. Being overweight and obese has been linked to a number of non-communicable, chronic diseases. Pathophysiology of Obesity-Induced Health Complications is a compilation of review articles dedicated to describe co-morbidities associated with obesity. The wide range that is covered is of significant interest to basic research scientists, clinicians and graduate students who are engaged in studying obesity-induced health complications. Furthermore, this book highlights the potential of novel approaches for the prevention and treatment of obesity and its related illnesses. Nineteen articles in this book are organized in four sections that are designed to provide an overview of obesity-induced health complications. The first section serves as an introductory section on the prevalence, causes, consequences, treatments and preventive approaches for obesity. Section two covers the metabolic disturbances and inflammation due to obesity. The third section is focused on neurological and visceral complications as a consequence of obesity. The final section covers strategies for the prevention of obesity-induced complications. The book illustrates that obesity can result in a diverse range of pathophysiological conditions that adversely affect health.
    Type of Medium: Online Resource
    Pages: XVI, 345 p. 40 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030353582
    Series Statement: Advances in Biochemistry in Health and Disease, 19
    DDC: 612
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Clinical biochemistry. ; Proteins . ; Pharmacology. ; Human Physiology. ; Medical Biochemistry. ; Protein Biochemistry. ; Pharmacology.
    Description / Table of Contents: 1. The Role of Chemokine Receptors in Renal Fibrosis -- 2. Inflammatory biomarkers for cardiovascular risk stratification in familial hypercholesterolemia -- 3. Beyond the paradigm: novel functions of renin-producing cells -- 4. Role of ASIC1a in normal and pathological synaptic plasticity -- 5. Stationary and Non-stationary ion- and Water Flux Interactions in Kidney Proximal Tubule: Mathematical Analysis of Isomotic Transport by a Minimalistic Model -- 6. Correction to: Stationary and Nonstationary Ion and Water Flux Interactions in Kidney Proximal Tubule: Mathematical Analysis of Isosmotic Transport by a Minimalistic Model.
    Abstract: The Role of Chemokine Receptors in Renal Fibrosis Fenglei Wu, Chi Sun, and Jianquan Liu Inflammatory Biomarkers for Cardiovascular Risk Stratification in Familial Hypercholesterolemia Afsane Bahrami, Luca Liberale, Željko Reiner, Federico Carbone, Fabrizio Montecucco, and Amirhossein Sahebkar Beyond the Paradigm: Novel Functions of Renin-Producing Cells Anne Steglich, Linda Hickmann, Andreas Linkermann, Stefan Bornstein,Christian Hugo, and Vladimir T. Todorov Role of ASIC1a in Normal and Pathological Synaptic Plasticity Dalila Mango and Robert Nisticò Stationary and Nonstationary Ion and Water Flux Interactions in Kidney Proximal Tubule: Mathematical Analysis of Isosmotic Transport by a Minimalistic Model Erik Hviid Larsen and Jens Nørkær Sørensen Correction to: Stationary and Nonstationary Ion and Water Flux Interactions in Kidney Proximal Tubule: Mathematical Analysis of Isosmotic Transport by a Minimalistic Model Erik Hviid Larsen and Jens Nørkær Sørensen Chapter “Stationary and Non-Stationary Ion- and Water Flux Interactions in Kidney Proximal Tubule. Mathematical Analysis of Isosmotic Transport by a Minimalistic Model“ is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VII, 150 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030614959
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 177
    DDC: 612
    Language: English
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  • 6
    Keywords: Human physiology. ; Nanotechnology. ; Cancer. ; Nanochemistry. ; Bacteria. ; Human Physiology. ; Nanotechnology. ; Cancer Biology. ; Nanochemistry. ; Bacteria.
    Description / Table of Contents: Chapter 1. Research Progression on Studies Related to Green Synthesis Nanoparticles: A Bibliometric Review -- Chapter 2. Current Green Nanotechnology: The Case of Noble Metal Nanocomposites and Applications -- Chapter 3. Role of Solvent System in Green Synthesis of Nanoparticles -- Chapter 4. Surface Engineering Techniques Associated with Stability, Biocompatibility and Toxicity of Nanoparticles -- Chapter 5. Role of Light in the Improvement of Nanoparticles Synthesis -- Chapter 6. Application of Nanomaterials for Cancer Diagnosis and Therapy -- Chapter 7. Marine Resources for Biosynthesis and Surface Modification of Anticancer Nanoparticles -- Chapter 8. Green Synthesis of Nanoparticles and Their Application in Cancer Therapy -- Chapter 9. Gold Nanoparticles: Biogenic Synthesis and Anticancer Application -- Chapter 10. Toxicity and Synthesis of Bacteriogenic Silver Nanoparticles Against Bacterial Pathogens: A Critical Review -- Chapter 11. Green Synthesis of Selenium Nanoparticles (SeNPs) via Environment-Friendly Biological Entities -- Chapter 12. Biogenic Synthesis, Characterization, Toxicity Assessment, Antiparasitic and Antibacterial Activities of Silver Nanoparticle from Lippia Multiflora -- Chapter 13. Green Synthesis of MgO Nanoparticles and its Effect on Chlorophyll Content in Plant Tissue Culture -- Chapter 14. Application of Green Nano-silica in Civil Engineering. .
    Abstract: This book describes various strategies for the synthesis of green nanoparticles using plant extracts and microbes, including the advantages and disadvantages of different methods and their applications. After discussing strategies for and the potential of green synthesis of noble metal nanoparticles, it highlights the role of the solvent system. The book then explores the stability/toxicity of nanoparticles and the associated-surface engineering techniques for achieving biocompatibility, and examines the antimicrobial efficacy of green nanoparticles with regard to various bacterial pathogens, as well as the underlying cytotoxicity mechanisms. Lastly, the book addresses the potential applications of various green nanoparticles in cancer theranostics, and reviews a number of plant-mediated nanoparticles as potential pharmaceutical agents. Given its scope, the book will be of interest to all scientists and students wanting to learn more about the synthesis and applications of green nanoparticles.
    Type of Medium: Online Resource
    Pages: XV, 316 p. 78 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551796
    DDC: 612
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Life sciences. ; Medical sciences. ; Pathology. ; Human Physiology. ; Life Sciences. ; Health Sciences. ; Pathology.
    Description / Table of Contents: Preface -- What is Metabolism? -- How Metabolism Works -- Carbohydrate Metabolism -- Mitochondria: The Batteries of Our Cells -- Lipid Metabolism -- Protein Metabolism -- Alcohol Metabolism -- Metabolism and Obesity -- Diabetes and Metabolism -- Metabolism in the Brain -- Metabolism and Heart Disease -- Metabolism in Exercise -- Cancer and Metabolism -- We are Stardust -- Glossary.
    Abstract: Most people know metabolism is somehow related to our food and tendency to gain or lose weight, but few people actually understand what metabolism is, and how it is essential for all living beings. This book explains the concept and scope of metabolism, how it works, and how metabolic dysfunction is related to diseases. Using language accessible for the general reader and storytelling, it explains which molecules our bodies are made of, how we build these molecules, and how we transform them and the food we eat within us. It also explains how errors in metabolic processes can lead to diseases, including obesity, diabetes, Parkinson´s disease, heart disease, stroke, and more. In essence, it is a user´s manual to explain how our bodies process, change, and use our food.
    Type of Medium: Online Resource
    Pages: VII, 151 p. 53 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030509682
    DDC: 612
    Language: English
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  • 8
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Nanotechnology. ; Biology Technique. ; Pharmacology. ; Human Physiology. ; Nanotechnology. ; Experimental Organisms. ; Pharmacology.
    Description / Table of Contents: Chapter 1. Synthesis and characterization of nanoparticles used in consumer products -- Chapter 2. Model organisms for in vivo assessment of nanoparticles -- Chapter 3. Impact of nanoparticles on behavior and physiology of Drosophila melanogaster -- Chapter 4. Dose-dependent influence of nanoparticles on fertility and survival -- Chapter 5. Effect of nanoparticles on maintenance of metabolic homeostasis -- Chapter 6. Nanoparticles: an activator of oxidative stress -- Chapter 7. Safe dose of nanoparticles: A boon for consumer goods and biomedical application.
    Abstract: This book offers an unparalleled source of information on in vivo assessment of nanoparticle toxicity by using Drosophila as a model organism. Nanoparticles have emerged as an useful tool for wide variety of biomedical, cosmetics, and industrial applications. However, our understanding of nanomaterial-mediated toxicity under in vivo condition remains limited. The book begins with a chapter on synthesis and characterization of nanoparticles used for various biological, medical and commercial purposes. The rest of the chapters deal with the impact of nanoparticles on different biological aspects like behavior, physiology and metabolic homoeostasis using Drosophila as a model organism. Lastly, the book summarizes how proper characterization and evaluation of safe dosage of nanoparticles can be a boon if incorporated in consumer goods and for biomedical applications. Overall, the book pursues an interdisciplinary approach by connecting nanotechnology and biology from various angles using Drosophila as a model system, so as to develop more efficient, safe and effective use of nanoparticles for human beings.
    Type of Medium: Online Resource
    Pages: XII, 122 p. 34 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811555220
    DDC: 612
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Physiology. ; Respiratory organs. ; Human Physiology. ; Physiology. ; Respiratory Physiology.
    Description / Table of Contents: Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A review -- Self-Reported Survey on Allergy Symptoms among First-Year Students in Veterinary Medicine: a Preamble to the AllergoVet Cohort Study -- The Pattern of Sensitization Influences Exhaled and Nasal Nitric Oxide Levels in Young Adults -- Discrimination between Atopic, Allergic, and Asthmatic Volunteers for Human Exposure Studies on Sensory Irritation -- Impaired Coordination and Recruitment of Muscle Agonists, but not Abnormal Synergies or Co-contraction, Have a Significant Effect on Motor Impairments after Stroke -- Prognostics of Hospitalization Length and Mortality in Patients with Traumatic Frontal Brain Contusions -- Circulating P-Selectin and its Glycoprotein Ligand in Non-Diabetic Obstructive Sleep Apnea Patients -- Nutritional Status and Dietary Patterns in Adults with Severe Obstructive Sleep Apnea -- Medication Compliance in COPD Patients -- Seasonality of Respiratory Syncytial Virus Hospitalization -- Factors Affecting Influenza Vaccination Rate in Adults with Asthma -- Respiratory Complications in Children Hospitalized with Respiratory Syncytial Virus Infection.
    Abstract: This book offers a reliable source of information on the latest advances and current trends in the medical and clinical sciences. The focus is on certain fields that are of consistently high practical interest due to widespread disease morbidity, and on pathomechanisms that are not yet fully understood and their treatment. The topics covered include, but are not limited to, the search for novel biomarkers of colorectal cancer, morbidity and mortality after traumatic brain injuries, and impairment in brain-controlled muscle mechanisms after stroke. In addition, problematic issues in pulmonary medicine are discussed at length. These issues, notably, concern human studies that have set the standards for allergy, sensory irritation, and sensitization research, as well as studies on the management and treatment of chronic obstructive pulmonary disease and obstructive sleep apnea. Lastly, the book addresses various aspects of commonplace viral respiratory infections, such as vulnerability and transmission in both pediatric and adult populations, flue vaccination coverage, and post-infectious respiratory complications. The book’s goal is to promote the restoration and maintenance of good health, disease prophylaxis, and improved patient management by integrating research into clinical work and findings on improving care. It offers a valuable asset for clinical specialists, researchers, and everyone engaged in healthcare.
    Type of Medium: Online Resource
    Pages: VI, 120 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030511210
    Series Statement: Clinical and Experimental Biomedicine, 1279
    DDC: 612
    Language: English
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  • 10
    Keywords: Human physiology. ; Neurosciences. ; Pharmacology. ; Hematology. ; Neurology . ; Human Physiology. ; Neuroscience. ; Pharmacology. ; Hematology. ; Neurology.
    Description / Table of Contents: Structure of the Mammalian Choroid Plexus -- Blending Established and New Perspectives on Choroid Plexus-CSF Dynamics -- A Frog Model for CSF Secretion -- Cotransport of Water in the Choroid Plexus Epithelium: From Amphibians to Mammals -- The Significance of the Choroid Plexus for Cerebral Iron Homeostasis -- Acid/Base Transporters in CSF Secretion and pH Regulation -- TRPV4, a Regulatory Channel in the Production of Cerebrospinal Fluid by the Choroid Plexus -- Neuroprotective Mechanisms at the Blood-CSF Barrier of the Developing and Adult Brain -- Roles of the Choroid Plexus in Aging -- Choroid Plexus Tumors -- Roles of the Choroid Plexus in CNS Infections -- Hydrocephalus.
    Abstract: This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.
    Type of Medium: Online Resource
    Pages: VI, 287 p. 65 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9781071605363
    Series Statement: Physiology in Health and Disease,
    DDC: 612
    Language: English
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  • 11
    Keywords: Human physiology. ; Human Physiology.
    Description / Table of Contents: Biochemistry of cardiovascular dysfunction in obesity -- Vascular mechanisms linking RAAS components to obesity-associated hypertension -- Mechanisms of obesity-induced hypertension in adolescents -- Role of the sympathetic nervous system in obesity-induced hypertension -- Sex differences in the mechanisms associated with obesity-induced hypertension -- Leptin as a mediator of obesity-induced hypertension -- Endothelial dysfunction in obesity -- Neurohormonal regulation of sympathoexcitation and hypertension in obesity -- Role of obesity in hypertension in children -- Small for gestational age and obesity associated co-morbidities -- Obesity-Related Hypertension in Children -- The relationship between obesity and hypertension -- Hypertension in Obesity and the Impact of Weight Loss -- Parallels in the Evolution of Obesity and Hypertension -- Obesity and hypertension -- The microcirculation: a key player in obesity-associated cardiovascular disease -- Sex Differences in Leptin Control of Cardiovascular Function in Health and Metabolic Diseases -- Sex differences in the role of leptin and coronary heart disease -- Differential effect of subcutaneous abdominal and visceral adipose tissue on cardiometabolic risk -- Sex differences in lipid and lipoprotein metabolism -- Sex differences in the mechanisms of obesity-induced hypertension -- Impaired cardiac function in obese individuals -- Role of Vitamin D deficiency in cardiac function -- Obesity in advanced heart failure -- Cardiovascular morbidity and mortality associated with obesity -- Risk of overweight with the development of heart failure -- Obesity and heart failure -- Obesity phenotypes and their paradoxical association with cardiovascular diseases -- Mechanisms of heart failure with preserved ejection fraction in obesity -- Obesity and cardiovascular diseases -- Obesity and Heart Failure: Possible mechanisms of the Obesity Paradox -- Prognosis of morbid obesity patients with advanced heart failure -- BMI as a risk factor for cardiovascular disease -- Relationship between BMI and cardiovascular outcomes in diabetic patients -- Cardiometabolic risk in obese children -- Gender related differences in obesity associated cardiovascular complications -- Understanding the mechanisms and clinical significance of the obesity paradox -- Advances in understanding gender difference in cardiometabolic disease risk -- Cardiovascular and Metabolic Complications – Diagnosis and Management in Obese Children -- Obesity and Ventricular Repolarization.
    Abstract: Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead to the occurrence of myocardial abnormalities and vascular alterations in obesity. We will also have some discussion on the biochemistry of the so-called obesity paradox in relation to CVD. The contributors to this book are international experts on obesity and associated cardiovascular complications. This book is also uniquely positioned as it focuses on the biochemistry of obesity-induced cardiovascular dysfunction. There are 20 chapters in 2 different parts in this book, comprising of Part A: Pathophysiology of Cardiovascular Complications in Obesity (11 chapters) and Part B: Modification of Cardiovascular Dysfunction in obesity (9 chapters). The intent of this volume is to provide current and basic understanding of the biochemical mechanisms of obesity induced cardiovascular dysfunction that will be of value not only to cardiologists and other allied health professionals, but will also stimulate and motivate biomedical researchers and scientists to find the way to prevent the epidemic of obesity associated cardiovascular abnormalities. Furthermore, this book will serve as a highly useful resource for medical students, fellows, residents and graduate students with an interest in the cardiovascular system. In summary, this book covers a broad range of biochemical mechanisms of obesity-induced cardiovascular complications. We hope that the reader will understand that obesity is linked to an increase in the risk and occurrence of fatal CVD. Furthermore, the underlying message presented in the book is that the cause of obesity related disorders is complex and that understanding the biochemistry of cardiovascular dysfunction may contribute to the development of novel interventions for the prevention and treatment of obesity associated comorbidities.
    Type of Medium: Online Resource
    Pages: XV, 401 p. 55 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030473365
    Series Statement: Advances in Biochemistry in Health and Disease, 20
    DDC: 612
    Language: English
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  • 12
    Keywords: Human physiology. ; Neurology . ; Anatomy. ; Neurosciences. ; Internal medicine. ; Human Physiology. ; Neurology. ; Anatomy. ; Neuroscience. ; Internal Medicine.
    Description / Table of Contents: Salivary gland: Savilon -- Oesophageal sphincters: Upper oesophageal sphincter and lower oesophageal sphincter -- Stomach as an Acid Producer -- Homeostasis of gastric acid secretion: neurocrine, paracrine and endocrine system, proton pump inhibitors. Alkaline tide -- Gastric mucosal barrier, Helicobacter pylori -- Gastric motility: (Migrating Motor Complex, Receptive Relaxation, Accommodation, Retropulsion) -- Gastric Emptying -- Gastrointestinal Rhythmic Contractions Electrical Basis: Slow wave potential -- Migratory Motor Complex (or migrating myoelectric complex), MMC, Motilin -- Motility: Peristalsis, Segmentation, Haustration and Mass movement -- Motility: Peristalsis, Segmentation, Haustration and Mass movement -- Recycling of bile salts: Enterohepatic Circulation (EHC) -- Intestinal Fluid Handling: Absorption -- Intestinal Fluid Handling: Secretion -- Pancreatic Exocrine function: Pancreatic acinar cell in pancreatic secretion, cholecystokinin (CCK), Auto- digestion -- Pancreatic Exocrine function: Pancreatic ductal cell, CFTR chloride channel. Secretin -- Carbohydrate Digestion: Small intestine as the site of digestion and absorption for dietary carbohydrate -- Fat digestion: Bile salt, emulsification, micelles, lipases, chylomicrons -- Protein Digestion -- Protein Absorption -- Defecation Reflex: Parasympathetic defecation reflex, intrinsic myenteric defection reflex -- Resting Membrane Potential (RMP) -- Equilibrium Potential -- Membrane conductance -- Action Potential -- Neuronal excitability -- Neuronal refractory period -- Initiation zone -- Saltatory conduction -- Firing rate -- Post-synaptic potentials -- Synaptic delay -- Summation -- Neurotransmitter -- Presynaptic inhibition -- Adequate stimulus -- Stimulus transduction -- Stimulus coding -- Adaptation -- Sensory discrimination (acuity) -- Motor neurons -- Neuromuscular junction -- Proprioception -- Spinal reflex -- Alpha-gamma coactivation.
    Abstract: This second volume of Defining Physiology: Principles, Themes, Concepts. continues on the same format as the first. In this new release, a selection of 44 essential topics in each major organ system is defined, then major themes, concept and principles surrounding these words in their physiologic scenarios are elaborated. For each keyword, a question is posed at the end of the text to test for a better understanding of the associated physiology of nervous and gastrointestinal systems. This book presents an easy reference guide for those just starting out in the area of physiology and for those who are interested in clear and succinct definitions of key terms.
    Type of Medium: Online Resource
    Pages: XII, 112 p. 42 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030622855
    DDC: 612
    Language: English
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  • 13
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Enzymology. ; Pharmacology. ; Human Physiology. ; Enzymology. ; Pharmacology.
    Description / Table of Contents: Overview -- Foreign Compounds: Foods, Drugs and Other Chemicals -- Absorption, Metabolism and Excretion of Foreign Compounds -- Metabolism of Foreign Compounds -- Bioactivation Metabolism: Activation Enzymes -- Functionalization Reactions Catalyzed by Activation Enzymes -- Detoxifying Metabolism: Detoxification Enzymes -- Conjugation Reactions Catalyzed by Detoxification Enzymes -- Reactive Intermediates Generated from Bioactivation -- Electrophilic Nature of Metabolic Reactive Intermediates -- Oxidative Stress Mediated by Reactive Intermediates -- Xenobiotics Bioactivation - Mediated Cellular Damages -- Nrf2 - ARE Pathway: Defense Against Oxidative Stress -- Genetic Variations and Polymorphisms of Metabolic Enzymes -- Enzyme Polymorphisms Affecting Xenobiotic Toxicity -- Inducibility of foreign Compound Metabolic Enzymes -- Induction of Enzymes for Health Benefits -- Diversity of Metabolic Enzyme Modulators -- Dietary Inducers of Detoxification Enzymes.
    Abstract: This book provides a comprehensive, organized, and concise overview of Xenobiotic Metabolic Enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 – ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.
    Type of Medium: Online Resource
    Pages: XVII, 239 p. 53 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030416799
    DDC: 612
    Language: English
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  • 14
    Keywords: Human physiology. ; Medicine Research. ; Biology Research. ; Pathology. ; Physiology. ; Human Physiology. ; Biomedical Research. ; Pathology. ; Animal Physiology.
    Description / Table of Contents: Salivary glands' anatomy and physiology -- Saliva in ingestive behavior research: association with oral sensory perception and food intake -- Saliva - a non-invasive sample: Pros and Cons -- Methodology assays for the salivary biomarkers’ identification and measurement -- The role of saliva in dental practice -- Salivary biomarkers in respiratory diseases -- Salivary biomarkers in neurologic diseases -- Salivary biomarkers in the diagnosis and monitoring of metabolic and endocrine diseases -- Salivary markers in inflammatory and autoimmune diseases -- Salivary biomarkers in oral and systemic pathologies. Kidney diseases -- Salivary diagnosis of infectious diseases -- Salivary markers in systemic and oral cancer -- Saliva in sport sciences -- Salivary biomarkers in welfare studies -- The future of saliva as an analytical sample.
    Abstract: Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.
    Type of Medium: Online Resource
    Pages: X, 326 p. 23 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030376819
    DDC: 612
    Language: English
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  • 15
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Lipids. ; Cardiovascular system. ; Physiology. ; Human Physiology. ; Lipidology. ; Cardiovascular Physiology.
    Description / Table of Contents: Chapter 1: Impact of Phospholipid Transfer Protein in Lipid Metabolism and Cardiovascular Diseases -- Chapter 2: Cholesteryl Ester Transfer Protein and Lipid Metabolism and Cardiovascular Diseases -- Chapter 3: Lipopolysaccharide Binding Protein and Bactericidal/Permeability-increasing Protein in Lipid Metabolism and Cardiovascular Diseases -- Chapter 4: Microsomal Triglyceride Transfer Protein: From Lipid Metabolism to Metabolic Diseases -- Chapter 5: Circadian-Clock Regulation on Lipid Metabolism and Metabolic Diseases -- Chapter 6: ABC Transporters, Cholesterol Efflux and Implications for Cardiovascular Diseases -- Chapter 7: Apolipoprotein M: research progress and clinical perspective -- Chapter 8: Recent Advances in the Critical Role of the Sterol Efflux Transporters ABCG5/G8 in Health and Disease -- Chapter 9: Proprotein Convertase Subtilisin/Kexin-type 9 and Lipid Metabolism -- Chapter 10: LDL and HDL Oxidative Modification and Atherosclerosis -- Chapter 11: Rare Diseases Related with Lipoprotein Metabolism -- Chapter 12: Preβ1 High Density Lipoprotein in Cardiovascular Diseases -- Chapter 13: CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis -- Chapter 14: Mfsd2a, a physiologically important lysolipid transporter in brain and eye.
    Abstract: This book provides an up-to-date review of the fundamentals of lipid metabolism and its role in cardiovascular diseases. Focusing on lipid transfer proteins in the circulation and cells, the role of important lipid transporters, the effect of recently discovered lipid binding proteins, and the link between lipid metabolism disorders and cardiovascular diseases, it covers phospholipid transfer protein, cholesteryl ester transfer protein, lipopolysaccharide binding protein, microsomal triglyceride transfer protein, ABC binding cassette members, and more. The book offers graduate students and researchers a coherent overview of lipid transfer and transport, as well as the limitations of current research in the field, and promotes further studies on cardiovascular diseases, as well as pharmaceutical research on drug discovery based on lipid transfer, transport, and binding.
    Type of Medium: Online Resource
    Pages: VIII, 234 p. 38 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811560828
    Series Statement: Advances in Experimental Medicine and Biology, 1276
    DDC: 612
    Language: English
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  • 16
    Keywords: Human physiology. ; Food science. ; Nutrition   . ; Geriatrics. ; Medicine, Preventive. ; Health promotion. ; Human Physiology. ; Food Science. ; Nutrition. ; Geriatrics. ; Health Promotion and Disease Prevention.
    Description / Table of Contents: Chapter 1_ Ageing: demographic and epidemiological aspects -- Chapter 2_ Ageing phenotypes -- Chapter 3_ Age-related diseases -- Chapter 4_ Assessment of Nutritional Status in older people -- Chapter 5_Nutrients and nutraceuticals in ageing -- Chapter 6_ Impact of Dietary fiber on Ageing -- Chapter 7_ Dietary Polyphenols for Active & Healthy Ageing -- Chapter 8_ Caloric Restriction in relation to nutrients and nutraceuticals in ageing -- Chapter 9_Anti-inflammatory Nutrients and Nutraceuticals in ageing -- Chapter 10_Anti-oxidant Nutrients and Nutraceuticals in ageing -- Chapter 11_ Functional Foods, and Dietary Patterns for Prevention of Cognitive Decline in ageing -- Chapter 12_ Mediterranean Diet for Active & Healthy Ageing -- Chapter 13_ Technological tools to promote nutraceutical diets and to improve nutrition in older people -- Chapter 14_ Conclusion.
    Abstract: This book focuses on the nutrients and nutraceuticals that promote active and healthy ageing – recently defined by the WHO as the process of development and maintenance of functional capacity that allows well-being at an advanced stage of life. There has been a rapid rise in the use of nutritional interventions as well as specific nutraceuticals in the management of multifactorial aspects of clinical health outcomes. Written by leading experts this book comprehensively discusses the various ageing phenotypes and age-related diseases. It also assesses the nutritional status of the elderly and the various epidemiological factors that influence it. It reviews the role of dietary fiber in disease-free and fully functional ageing. Further, the book explores the benefits of polyphenols, which are secondary plant metabolites, in protecting against cancer, cardiovascular diseases, and various neurodegenerative diseases.
    Type of Medium: Online Resource
    Pages: VII, 282 p. 30 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811535529
    DDC: 612
    Language: English
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  • 17
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Clinical biochemistry. ; Proteins . ; Pharmacology. ; Human Physiology. ; Medical Biochemistry. ; Protein Biochemistry. ; Pharmacology.
    Description / Table of Contents: 1. CXC Chemokine Receptors in the Tumor Microenvironment and an Update of Antagonist Development -- 2. Molecular Mechanisms of Fuchs and Congenital Hereditary Endothelial Corneal Dystrophies -- 3. Promising Anti-Atherosclerotic Effect of Berberine; Evidence from in Vitro, in Vivo, and Clinical Studies -- 4. Ion channels in glioma malignancy. .
    Abstract: CXC Chemokine Receptors in the Tumor Microenvironment and an Update of Antagonist Development Yang Xun, Hua Yang, Jiekai Li, Fuling Wu, and Fang Liu Molecular Mechanisms of Fuchs and Congenital Hereditary Endothelial Corneal Dystrophies Darpan Malhotra and Joseph R. Casey Promising Anti-Atherosclerotic Effect of Berberine; Evidence from in Vitro, in Vivo, and Clinical Studies Alireza Fatahian, Saeed Mohammadian Haftcheshmeh, Sara Azhdari, Helaleh Kaboli Farshchi, Banafsheh Nikfar, and Amir Abbas Momtazi-Borojeni Ion channels in glioma malignancy Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, and Fabio Franciolini.
    Type of Medium: Online Resource
    Pages: VII, 110 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030615079
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 178
    DDC: 612
    Language: English
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  • 18
    Keywords: Human physiology. ; Medicine Research. ; Biology Research. ; Proteins . ; Biological transport. ; Cell membranes. ; Human Physiology. ; Biomedical Research. ; Protein Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. Organoids as a Model for Intestinal Ion Transport Physiology -- 2. Secretory Diarrhea -- 3. Role of the Epithelium in Diseases of the Intestine -- 4. Diseases of the Pancreas Involving Channels/Transporters -- 5. Fundamentals of Ion Transport across Human Sweat Gland in Health and Disease -- 6. Transporters in the Lactating Mammary Epithelium -- 7. Lipid Transport Across the Mammary Gland -- 8. Ion Transport across Inner Ear Epithelia -- 9. Regulation of Ion Transport through Retinal Pigment Epithelium: Impact in Retinal Degeneration -- 10. Ion Transport in the Choroid Plexus Epithelium -- 11. Transport Functions of Ectoderm Epithelial Cells Forming Dental Enamel. .
    Abstract: This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.
    Type of Medium: Online Resource
    Pages: XIX, 382 p. 77 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030553104
    Series Statement: Physiology in Health and Disease,
    DDC: 612
    Language: English
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  • 19
    Keywords: Human physiology. ; Bioorganic chemistry. ; Bioinformatics. ; Medical physics. ; Human Physiology. ; Bioorganic Chemistry. ; Computational and Systems Biology. ; Medical Physics.
    Description / Table of Contents: Organisation of the Body -- Cells and Tissues -- Measurement, Errors, Data and Unit Conversion -- Chemistry for Physiology -- Integument -- Homeostasis -- Skeletal System -- Muscular System -- Gastro-Intestinal System -- Endocrine System -- Renal System -- Cardiovascular System -- Respiratory System -- Nervous System -- Reproductive System -- Waves, Light Waves, Sound Waves, Ultrasound (the physics of) -- Ionising Radiation -- Electricity -- Biomechanics -- Body Temperature, Energy and Heat Loss -- 64 Essay topics for a written assignment assessment in Anatomy & Physiology Challenging essay topics.
    Abstract: This third edition provides 2900 multiple choice questions on human anatomy and physiology, and some biophysical science, separated into 20 chapters and 68 categories. In addition, there are 64 essay topics. The answer to each question is accompanied by an explanation. Each chapter has an introduction to set the scene for the questions to come. However, not all possible information is provided within these Introductions, so an Anatomy and Physiology textbook is an indispensable aid to understanding the answers. The textbook offers a more holistic approach to the subjects of anatomy and physiology by also including biomechanics, biophysics and biochemistry. The questions have been used in end-of-semester examinations for undergraduate anatomy and physiology courses, and as such, reflect the focus of these particular courses and are pitched at this level to challenge students that are beginning their training in anatomy and physiology. The question and answer combinations are intended for use by teachers, to select questions for their next examinations, and by students, when studying for an upcoming test. Students enrolled in the courses for which these questions were written include nursing, midwifery, paramedic, physiotherapy, occupational therapy, nutrition and dietetics, health sciences, exercise science, and students taking an anatomy and physiology course as an elective.
    Type of Medium: Online Resource
    Pages: XVII, 742 p. 18 illus. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030473143
    DDC: 612
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Respiratory organs. ; Physiology. ; Epidemiology. ; Human Physiology. ; Respiratory Physiology. ; Epidemiology.
    Description / Table of Contents: Nosocomial Infections in Patients Hospitalized with Respiratory Syncytial Virus: A Practice Review -- Regional Activity and Spread of Influenza Viruses in Poland in the Context of Neighboring Countries in the Epidemic Season 2017/18: An Epidemiological Review -- Bacteremia in Children Hospitalized Due to Respiratory Syncytial Virus Infection -- Multi-Spectral Pattern of Clinical Presentation and the Resultant Outcome in Central Nervous System Tuberculosis: A Single Center Audit on the Ubiquitous Pathogen -- Adherence to Therapy in Chronic Obstructive Pulmonary Disease: A Systematic Review -- How Healthy Is Healthy? – Comparison between Self-Reported Symptoms and Clinical Outcomes in Connection with the Enrollment of Volunteers for Human Exposure Studies on Sensory Irritation Effects -- Coexpression of Hsp70 Protein and Autophagy Marker Protein LC3 in A549 C ells and THP1 Cells Exposed to Nanoparticles of Air Pollution -- Whole Blood Assay as a Tool to Describe the Effects of Zinc Oxide Exposure on Innate Immunity -- Depression and Serum Content of Serotonin in Adult Patients with Atopic Dermatitis -- Evaluation of Nocturnal Respiratory Complaints in Pregnant Women -- Cardiovascular Function in Obstructive Sleep Apnea Patients with Controlled Hypertension -- Diagnosis of Sleep-Disordered Breathing in the Home Environment.
    Abstract: This book shares the experimental findings and views in current multidisciplinary medical science combining both basic and applied research aimed at resolving problematic health issues. The key topics address contagious diseases, in particular the epidemiology, clinical presentation, and management of influenza and influenza-like infections as well as brain tuberculosis. Pulmonary medicine is represented by articles addressing a range of practical issues, including the diagnosis, symptoms, comorbidities, and treatment of obstructive sleep apnea, a syndrome whose incidence shows a persistent upward trend worldwide. Other articles address the pathogenesis of air pollution toxicity and allergy and sensory irritation in toxic exposure studies. An intriguing relation of atopic dermatitis to depression and serotoninergic system is debated. The book attempts to integrate research into clinical work and to implement findings to improve care and to decrease suffering from diseases. It is dedicated to the practicing professionals, researchers, and all engaged in health care.
    Type of Medium: Online Resource
    Pages: VI, 112 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504984
    Series Statement: Clinical and Experimental Biomedicine, 1271
    DDC: 612
    Language: English
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  • 21
    Keywords: Human physiology. ; Nutrition   . ; Embryology. ; Physiology. ; Human Physiology. ; Nutrition. ; Embryology. ; Physiology.
    Description / Table of Contents: Chapter 1. How Dietary Deficiency Studies have Illuminated the Many Roles of Vitamin A during Development and Postnatal Life -- Chapter 2. Maternal-fetal Transfer of Vitamin A and its Impact on Mammalian Embryonic Development -- Chapter 3. Retinoic Acid-Regulated Target Genes during Development: Integrative Genomics Analysis -- Chapter 4. RA Signaling in Limb Development and Regeneration in Different Species -- Chapter 5. Retinoic Acid Signaling and Heart Development -- Chapter 6. Retinoic Acid Signaling and Development of the Respiratory System -- Chapter 7. Retinoic Acid Signaling and Zebrafish Dentition during Development and Evolution -- Chapter 8. Fetal Alcohol Spectrum Disorder: Embryogenesis under Reduced Retinoic Acid Signaling Conditions.
    Abstract: This book covers subjects that have major impacts on society, such as the mechanism of maternal-fetal transfer of vitamin A, and the effects of alcohol on retinoic acid signaling and mammalian embryonic development. There has been an awareness of the importance of consuming vitamins throughout human history, but empirical studies of their physiological role and mode of action only began about 150 years ago. Since then, the biochemical nature of vitamin A and its active derivative, retinoic acid, have been identified and researchers around the globe have investigated retinoic acid’s physiological function in growth processes and in maintaining life Written by leading experts, this book discusses the latest findings and advances in retinoic acid research. It addresses topics such as the role of retinoic acid signaling in a multitude of processes, including limb, heart and respiratory system development, as well as its role in maintaining postnatal organ systems. This book is a valuable resource for scientists involved in vitamin A/retinoic acid research and readers interested in developmental biology.
    Type of Medium: Online Resource
    Pages: VII, 229 p. 42 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030422820
    Series Statement: Subcellular Biochemistry, 95
    DDC: 612
    Language: English
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  • 22
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Neurosciences. ; Endocrinology. ; Nephrology. ; Human Physiology. ; Neuroscience. ; Endocrinology. ; Nephrology.
    Description / Table of Contents: Chapter 1. Neurophysiology and Renal system -- Chapter 2. Normal physiology of Renal System -- Chapter 3. Brain – Kidney crosstalk.
    Abstract: This book discusses normal brain physiology and renal physiology, as well as the interactions between the two. The physiology of the brain can easily be affected by any changes to the physiology of other systems, which in turn may compromise cerebral blood flow and oxygenation. Together the brain and the renal system help our body systems to function automatically. The book addresses the basic aspects of neurophysiology and renal physiology in three broad sections, the first of which covers the basic principles of cerebral physiology and neural regulation of the renal system. The second part reviews the normal physiology of the renal system, including the mechanism of action, while the last section summarizes the correlation between the brain and kidney. Highly informative and clearly structured, the book provides essential insights for anyone with an interest in physiology and medicine.
    Type of Medium: Online Resource
    Pages: XIII, 117 p. 53 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811523250
    Series Statement: Physiology in Clinical Neurosciences – Brain and Spinal Cord Crosstalks,
    DDC: 612
    Language: English
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  • 23
    Keywords: Human physiology. ; Medicine Research. ; Biology Research. ; Proteins . ; Biological transport. ; Cell membranes. ; Human Physiology. ; Biomedical Research. ; Protein Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. Techniques in Epithelial Transport -- 2. Understanding Transepithelial Current Measurements -- 3. Mathematical Modeling of Epithelial Ion Transport -- 4. Rationale of Epithelia Transport -- 5. Establishment of Epithelial Polarity -- 6. Molecular Mechanisms of Apical and Basolateral Sorting in Polarized Epithelial Cells -- 7. Membrane Protein Folding and Structure -- 8. Epithelial Ion Channel Folding and ER Associated Degradation (ERAD) -- 9. Fundamentals of Epithelial Cl- Transport -- 10. Fundamentals of Epithelial Na+ Absorption -- 11. Physiologic Influences of Transepithelial K+ Secretion -- 12. Volume Regulation in Epithelia -- 13. Fundamentals of Bicarbonate Secretion in Epithelia -- 14. Sexual Dimorphism of Epithelial Ion Channels -- 15. Non-coding RNA-Dependent Regulation of Channels/Transporters. .
    Abstract: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike. .
    Type of Medium: Online Resource
    Pages: XIX, 563 p. 106 illus., 71 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030527808
    Series Statement: Physiology in Health and Disease,
    DDC: 612
    Language: English
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  • 24
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Human physiology. ; Internal medicine. ; Nutrition   . ; Surgery. ; Medicine Research. ; Biology Research. ; Human Physiology. ; Internal Medicine. ; Nutrition. ; Surgery. ; Biomedical Research.
    Description / Table of Contents: Introduction to Obesity and Diabetes– The windows of opportunity -- Nutrition transition and obesity trends in Argentina within the Latin American context -- Challenges and Economic Burden of Diabetes in Africa -- Brown adipose tissue in obesity and diabetes -- White and Brown Adipose Tissue in Obesity and Diabetes -- microRNAs in obesity and metabolic diseases -- From Adipogenic Viruses to Anti-Diabetic Drug: A Translational Journey -- Genetic profiles in the obese population -- The Upstream Environment for the Obesity Epidemic -- Inflammation and its role in obesity-related complications -- Cross talk between adipose tissue, macrophages and other immune cells: Development of obesity and inflammation-induced metabolic diseases -- Diabetes forecasts and statistics for the coming decades -- Pancreatic islets of Langerhans: adapting cell and molecular biology to changes of metabolism -- Targeting advanced glycation end products (esRAGE and sRAGE) for obesity, diabetes and its associated complications -- Anti-incretin effect: a missing link between obesity, diabetes and metabolic surgery -- An update on Mendelian forms of obesity and their personalized treatments -- The Genetic Basis of Diabetic Kidney Disease -- Epigenetics and chronic inflammation: Role in early detection of type 2 diabetes -- Salivary and Urinary Metabolome in Pediatric Obesity and Metabolic Syndrome -- State-of-the-Art Metabolomics Investigations of Type 2 Diabetes -- The gut microbiome and type 2 diabetes mellitus -- Immunotherapeutic Approach to the Treatment and Prevention of Obesity -- Metabolic Syndrome Update -- Non-alcoholic fatty liver disease: a global public health issue -- Non-Alcoholic Fatty Pancreatic Disease (NAFPD) -- Normal weight obesity – A hidden pandemic -- Obesity in Children/Adolescents and Obesity-Related Comorbidities -- Obesity and cancer: linked molecular mechanisms -- Cognitive impairment in obesity and diabetes -- Metabolic pathways underlying neuropsychiatric disorders and obesity -- Heart failure and the obesity paradox -- Inflammatory mechanisms in diabetic kidney disease -- The epidemiology of the diabetes - depression comorbidity in Brazil -inequality and interaction -- Contribution of Hyperglycemia and Unhealthy Diet to Cardiovascular Mortality -- Gestational Diabetes Mellitus -- Update on Gestational Diabetes -- Vascular complications in type 2 diabetes -- What We Know and Don’t about High-Intensity Sweeteners -- Personalised Molecular Feedback for Weight Loss -- Diabetes and Obesity in the Child and Adolescent: Guidelines and Challenges -- Type 2 diabetes – an unresolved disease -- Glucose control in the ICU -- Continuous glucose monitors as wearable lifestyle behavior change tools in obesity and diabetes -- Endoscopic techniques for obesity and diabetes -- Bariatric embolization: a possible non-surgical option for weight reduction -- Progress in noninvasive beta-cell mass imaging -- Cancer staging with 18F-FDG PET/CT in hyperglycemic patients -- Pancreatic Islet Transplantation: A Surgical Approach to Type 1 Diabetes Treatment -- Pancreatic Transplantation in Diabetes: Indications, Contraindications and Perspectives. -Pharmacotherapy of Type 2 Diabetes -- GLP1-Receptor Agonists in Diabetes: Drugs, General Effects, and Cardiovascular Impact -- Diabetes and treatments -- Treatment of Diabetes and Heart Failure -- Cardiovascular impact of newer diabetes medications -- Pathogenesis and Molecular Targets in treatment of Diabetic Wounds -- Efficiency in public health through the promotion of Diabetes Day Hospitals: a regional proposal -- Surgical options in obesity and diabetes -- One anastomosis gastric bypass in the treatment of obesity: effects on body weight and the metabolome -- Robotic bariatric surgery -- The Role of Obesity and Bariatric Surgery in the Management of Knee and Hip Osteoarthritis -- Relapse of diabetes after metabolic/bariatric surgery -- Malnutrition in Obesity -- Sugar-Sweetened Beverage Taxes: Origins, Mechanisms, and Current Worldwide Status -- Mobile Health Interventions for Weight Management in Overweight and Obese Populations -- Biomarkers and Machine Learning Applications in Obesity -- Current approaches in diabetes mellitus prediction: applications of machine learning and emerging biomarkers -- Polycystic ovary syndrome and sarcopenic obesity -- Drug Pipeline for Obesity Therapy -- MC4R as a Target for Pharmacotherapeutic Treatment of Obesity and Type-2 diabetes -- Nanotechnology: Can it be a crusader in diabesity? -- Old and new anti-obesity devices for medical, surgical, and endoscopical use -- Electroceutical approaches for gastroparesis -- Useful Online Resources Hosting Information on Obesity and Diabetes.
    Abstract: Now in its second edition, this comprehensive handbook provides a state-of-the-art overview of recent advances in drug and non-drug therapies for obesity and diabetes. It also addresses major comorbidities, covering topics such as, cardiovascular diseases, renal and neuropsychiatric disorders, appetite control and micro RNAs. Special attention is also devoted to pediatric care, including the latest recommendations for therapy and prevention. Obesity and type 2 diabetes are among the top global health-care budget concerns worldwide and impact professional practice at all levels: in hospitals, clinics and physicians’ offices alike. They prominently feature in headlines, and virtually no family, community or country is exempt from their protean, deleterious consequences. Furthermore, given the multiple intersections in their pathways, they often go hand in hand. The good news is that scientific advances in all fields, including genomics, metabolomics, lipidomics and microbiomics, are increasing our understanding of these two disease areas. At the same time, artificial intelligence, machine learning, mobile health and advanced implantable and external devices are rendering prevention and management more available, safe and cost-effective. In addition, bariatric and metabolic surgery has evolved from a niche specialty to an officially endorsed option for several modalities of obesity and diabetes. This book presents the latest lifestyle, pharmacological, surgical and non-surgical treatment options, including endoscopic intervention and cell therapy. Objectively reviewing natural and artificial sweeteners and critically examining issues such as public health initiatives, government mandated taxes for unhealthy foods and environmental planning, no stone is left unturned in gathering the latest practical information. As such, the book will appeal to seasoned specialists, as well as students and healthcare professionals in training.
    Type of Medium: Online Resource
    Pages: XV, 994 p. 176 illus., 158 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030533700
    DDC: 612
    Language: English
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  • 25
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Bioinformatics. ; Biotechnology. ; Human Physiology. ; Computational and Systems Biology. ; Biotechnology.
    Description / Table of Contents: Introduction of Quantitative Physiology -- Systems and Modelling -- Relevant Resources -- Modelling Gene Expression -- Bone and Body Mechanics -- Blood Dynamics -- Metabolic Network -- Systems pharmacology -- Calcium Signalling -- Modelling Neural Activity -- Cortical Spreading Depression (CSD) -- Heart Physiome -- Constructing genetic intelligence -- Brain Project.
    Abstract: Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics.
    Type of Medium: Online Resource
    Pages: XXI, 237 p. 246 illus., 97 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813340336
    DDC: 612
    Language: English
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