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  • 1
    Online Resource
    Online Resource
    Beyond Our Genes : Pathophysiology of Gene and Environment Interaction and Epigenetic Inheritance (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Genetics. ; Biotechnology. ; Medical Genetics. ; Genetics and Genomics. ; Chemical Bioengineering.
    Description / Table of Contents: Section I: The physiology of the gene/environment interaction -- Nutrition -- Physical Exercise -- Circadian Rhythm -- Toxicants: Smoke, Alcohol and Heavy Metals -- Hormones -- Section II: Gene-Environment Interaction and Disease Susceptibility -- Obesity and Metabolic Syndromes -- Cancer -- Neurological and Psychiatric Disorders -- Asthma and allergic disorders -- Lamarck Versus Darwin: The Concept of Aquired Epigenetic Inheritance -- Section III: Genome/Epigenome -- Genetic Contribution to Epigenetic Inheritance -- The Controversial Role of DNA Methylation in Epigenetic Inheritance -- Small Non-Coding RNAs -- Chromatin Modifiers -- Soma-to-Germline Information Transfer: Questions and Promises.
    Abstract: The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.
    Type of Medium: Online Resource
    Pages: VIII, 266 p. 11 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030352134
    URL: https://doi.org/10.1007/978-3-030-35213-4
    DOI: 10.1007/978-3-030-35213-4
    DDC: 616.042
    Language: English
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  • 2
    Online Resource
    Online Resource
    The Pangenome : Diversity, Dynamics and Evolution of Genomes (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbial genetics. ; Evolution (Biology). ; Population genetics. ; Microbial ecology. ; Medical genetics. ; Genetics. ; Microbial Genetics. ; Evolutionary Biology. ; Population Genetics. ; Microbial Ecology. ; Medical Genetics. ; Genetics and Genomics.
    Description / Table of Contents: Part 1: Genomic diversity and the pan-genome concept -- Chapter 1: The pan-genome: a data-drivendiscovery in biology -- Chapter 2: The prokaryotic species concept and challenges -- Chapter 3: Bacterial guide on how to design a diversified gene portfolio -- Chapter 4: A review of pan-genome tools and recent studies -- Part 2: Evolutionary biology of pan-genomes -- Chapter 5: Structure and dynamics of bacterial populations: pan-genome ecology -- Chapter 6: Bacterial microevolution and the pan-genome -- Chapter 7: Pan-genomes and selection: the public goods hypothesis -- Chapter 8: A pan-genomic perspective on the emergence, maintenance and predictability of antibiotic resistance -- Part 3: Pan-genomics: an open, evolving discipline -- Chapter 9: Metapangenome: at the crossroad of pangenomics and metagenomics -- Chapter 10: Pan-genome flux balance analysis towards pan-phenomes -- Chapter 11: Bacterial epigenomics: epigenetics in the age of population genomics -- Chapter 12: Eukaryotic pan-genomes -- Chapter 13: Computational strategies for eukaryotic pan-genome analyses.
    Abstract: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
    Type of Medium: Online Resource
    Pages: XIV, 307 p. 47 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030382810
    URL: https://doi.org/10.1007/978-3-030-38281-0
    DOI: 10.1007/978-3-030-38281-0
    DDC: 579.135
    Language: English
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  • 3
    Online Resource
    Online Resource
    Organotypic Models in Drug Development (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical genetics. ; Pathology. ; Pharmacology. ; Clinical Genetics. ; Pathology.
    Description / Table of Contents: Inflammatory skin disease models in vitro and in animals – predictability for drug development -- Neural In Vitro Models for Studying Substances Acting on the Central Nervous System -- Quality of commercial tissues Standardised Reconstructed Skin Models in Toxicology and Pharmacology: State of the Art and Future Development -- Human-Derived In Vitro Models Used for Skin Toxicity Testing Under REACh -- Disease Models: Lung models for testing drugs against inflammation and infection -- In Vitro Models of the Blood-Brain Barrier -- How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development -- The CAM Assay as an Alternative In Vivo Model for Drug Testing -- Organotypic Models in Drug Development “Tumor Models and Cancer Systems Biology for the Investigation of Anticancer Drugs and Resistance Development -- Tissue Engineering for Musculoskeletal Regeneration and Disease Modeling -- Immunocompetent human intestinal models in preclinical drug development -- Engineered Heart Muscle Models in Phenotypic Drug Screens.
    Abstract: This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.
    Type of Medium: Online Resource
    Pages: VIII, 323 p. 70 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030700638
    Series Statement: Handbook of Experimental Pharmacology, 265
    URL: https://doi.org/10.1007/978-3-030-70063-8
    DOI: 10.1007/978-3-030-70063-8
    DDC: 615
    Language: English
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  • 4
    Online Resource
    Online Resource
    The Secret Lives of Transcription Factors : In Heterochromatin Regulation (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Physiology. ; Medical genetics. ; Cell Biology. ; Physiology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors’ unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.
    Abstract: This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
    Type of Medium: Online Resource
    Pages: VI, 45 p. 6 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031290299
    Series Statement: SpringerBriefs in Biochemistry and Molecular Biology,
    URL: https://doi.org/10.1007/978-3-031-29029-9
    DOI: 10.1007/978-3-031-29029-9
    DDC: 571.6
    Language: English
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  • 5
    Online Resource
    Online Resource
    Druggable Lipid Signaling Pathways (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Medical genetics. ; Cancer. ; Lipids. ; Biomedical Research. ; Pharmacology. ; Medical Genetics. ; Cancer Biology. ; Lipidology.
    Description / Table of Contents: Preface -- Introduction of Druggable Lipid Signaling Pathway -- Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development -- Druggable Prostanoid Pathway -- Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress -- Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation -- Druggable Sphingolipid Pathway -- Druggable Lysophospholipid Pathway -- Druggable targets in endocannabinoid signaling -- Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections -- Druggable Lipid GPCRs: Past, Present, and Prospects. .
    Abstract: This edited work presents a series of reviews focusing on Druggable Lipid Signaling Pathways. It enables researchers in both academic institutions and industry as well as physicians to understand historical aspects of lipid signaling and future directions of drug discovery targeting lipid signaling pathways. This book provides 9 pathways including acyltransferases, prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, phosphoinositides, and lipid GPCRs. Readers will discover the importance of each lipid signaling pathway that contributes to broad range of diseases including neurological and neuropsychiatric diseases, pain, metabolic syndromes, cardiovascular diseases, cancer, dermatological diseases, fibrosis, inflammation, etc. Also, readers will recognize that many drugs targeting lipid signaling have been clinically used. Drugs currently under development are also discussed in each chapter, which includes some information about clinical trials and strategic drug designs. .
    Type of Medium: Online Resource
    Pages: VI, 260 p. 33 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506216
    Series Statement: Advances in Experimental Medicine and Biology, 1274
    URL: https://doi.org/10.1007/978-3-030-50621-6
    DOI: 10.1007/978-3-030-50621-6
    DDC: 610.72
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cell Biology and Translational Medicine, Volume 7 : Stem Cells and Therapy: Emerging Approaches (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Stem cells. ; Regenerative medicine. ; Medical genetics. ; Biotechnology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Clinical Genetics. ; Chemical Bioengineering.
    Description / Table of Contents: Application of iPSC to modelling of respiratory diseases -- Gene editing in human pluripotent stem cells: recent advances for clinical therapies -- Vascular wall as source of stem cells able to differentiate into endothelial cells -- Physiological and therapeutic roles of neuropeptide Y on biological functions -- Rho signaling-directed YAP/TAZ regulation encourages 3D spheroid colony formation and boosts plasticity of Parthenogenetic Stem Cells -- Transamniotic Stem Cell Therapy -- Regenerative medicine: Injectable cell-based therapeutics and approved products -- Stem Cell Therapy for Hepatocellular Carcinoma: Future Perspectives -- Potential of tribological properties of metalnanomaterials in biomedical applications -- The impact of the low frequency of the electromagnetic field on human.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the seventh volume of a continuing series Chapter “Application of iPSC to Modelling of Respiratory Diseases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 153 p. 30 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030378455
    Series Statement: Cell Biology and Translational Medicine, 1237
    URL: https://doi.org/10.1007/978-3-030-37845-5
    DOI: 10.1007/978-3-030-37845-5
    DDC: 571.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Messenger RNA Therapeutics (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Medicinal chemistry. ; Nanomedicine. ; Cancer Treatment. ; Medical Genetics. ; Medicinal Chemistry. ; Nanomedicine and Nanotoxicology. ; Cancer Therapy.
    Description / Table of Contents: The Democratization of RNA Therapeutics -- Supramolecular Strategies for mRNA Delivery -- In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of 21st Century: Exploitation of Peptides as Carriers for their Intracellular Delivery -- Effective Delivery of mRNA Therapeutics and Vaccines Using Lipid Nanoparticles -- Messenger RNA Therapeutics -- Formulation, Delivery and Application of mRNA Therapeutics In Respiratory Diseases -- Clinical Applications of mRNA Formulated In Lipid Nanoparticles -- Preparation of Messenger RNA Loaded Nanomedicine Applied on Tissue Engineering And Regenerative Medicine -- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics: Immune Activation By Ionizable Cationic Lipids -- Adjuvants, the Elephant in the Room for RNA Vaccines -- Addressing Skin with Modified mRNA Constructs for Novel Therapies -- mRNA-Based Cancer Immunotherapies -- From Bench to Bedside: The Journey of an mRNA Drug Candidate Into a Medicine -- Synthetic mRNA Gene Therapies for Chronic HBV Infection -- Delivery Vehicles for Self-Amplifying RNA -- Delivery Technologies of mRNA Vaccines -- Nanosystems: The Key in Formulations of mRNA for Several Pathologies -- Messenger RNA Nanoformulation For Cancer Vaccine -- Preparation of Synthetic mRNAs for In Vivo Applications – Overview and Considerations -- Messenger RNA for Prophylaxis -- Nuclear Export of mRNA with Disease Pathogenesis and Therapeutic Potentials -- Messenger RNA Therapeutics: Start of a New Era in Medicine -- mRNA Delivery Technologies for Therapeutic Applications.
    Abstract: This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics.
    Type of Medium: Online Resource
    Pages: XII, 446 p. 68 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031084157
    Series Statement: RNA Technologies, 13
    URL: https://doi.org/10.1007/978-3-031-08415-7
    DOI: 10.1007/978-3-031-08415-7
    DDC: 616.042
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cell Biology and Translational Medicine, Volume 9 : Stem Cell-Based Therapeutic Approaches in Disease (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Stem cells. ; Regenerative medicine. ; Medical genetics. ; Biotechnology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Medical Genetics. ; Biotechnology.
    Description / Table of Contents: Data Analysis of Infection Rates Among Exposed Healthcare Workers Could Reveal Effective Prophylactics Against SARS-CoV-2 -- Immune Responses to SARS-CoV, MERS-CoV AND SARS-CoV-2 -- Normothermic Preservation of Liver – What does the Future Hold? -- Tissues from Post-Mortem Donors as Alternative Sources of Stem Cells for Regenerative Medicine -- New Pioneers of Optogenetics in Neuroscience -- A Current Overview of Scaffold-Based Bone Regeneration Strategies with Dental Stem Cells -- The Importance of Stem Cell Senescence in Regenerative Medicine -- Hematological Malignancies and Fertility -- Unraveling polymeric nanoparticles cell uptake pathways: two decades working to understand nanoparticles journey to improve gene therapy -- Cellular Dust as a Novel Hope for Regenerative Cancer Medicine.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the ninth volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 163 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030549176
    Series Statement: Cell Biology and Translational Medicine, 1288
    URL: https://doi.org/10.1007/978-3-030-54917-6
    DOI: 10.1007/978-3-030-54917-6
    DDC: 571.6
    Language: English
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  • 9
    Online Resource
    Online Resource
    Clinical Genetics and Genomics of Aging (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Medical Genetics.
    Description / Table of Contents: Chapter 1: An Update On The Molecular Pillars Of Aging -- Chapter 2: Age-related Neurodegenerative Diseases: An Update -- Chapter 3: Molecular Aspects Of Hippocampal Aging -- Chapter 4: Mitochondrial Function in Aging -- Chapter 5: Genomic Tools Used in Molecular Clinical Aging Research -- Chapter 6: Molecular Biomarkers of Aging Studies in Humans -- Chapter 7: Alternative Splicing and Aging -- Chapter 8: Epigenetics and Aging -- Chapter 9: Microbiome Research and Aging -- Chapter 10: Molecular Basis of Progeroid Diseases -- Chapter 11: Applications of CRISPR-Cas in Aging Research -- Chapter 12: Pharmacological Treatment for Aging: Are We There? -- Chapter 13: Integrative Outlooks About Clinical and Biomedical Research in Aging.
    Abstract: The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.
    Type of Medium: Online Resource
    Pages: XV, 271 p. 12 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030409555
    URL: https://doi.org/10.1007/978-3-030-40955-5
    DOI: 10.1007/978-3-030-40955-5
    DDC: 616.042
    Language: English
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  • 10
    Online Resource
    Online Resource
    GeNeDis 2018 : Computational Biology and Bioinformatics (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: S-MEDUTA: Combining Balanced Scorecard with simulation and MCDA techniques for the evaluation of the strategic performance of an Emergency Department -- An Architecture For Cooperative Mobile Health Applications -- An Educational Scenario for the Learning of the Conic Section: Studying the Ellipse with the Use of Digital Tools and Elements of Differentiated Instruction and Cognitive Neurosciences 45 -- Antibody clustering using a machine learning pipeline that fuses genetic, structural and physicochemical properties -- Neuroeducation and computer programming. A review -- Towards Analyzing Next Generation Sequencing Algorithms -- WOL Ecosystem: Secure remote power-state control of computer(s) over the internet for telemedicine purposes and dementia patients -- Epidemics Fuzzy Decision-Making Applications and Fuzzy Genetic Algorithms Efficiency Enhancement -- Multivariate data analysis and machine learning for prediction of MCI-to-AD conversion -- A Deep Learning Approach for Human Action Recognition using Skeletal Information -- Artificial Neural Networks in Computer Aided Drug Design. An overview of recent advances -- Computation of dolphins’ sound aspl while foraging -- Novel cost function definition for minimum-cost Tractography in MR Diffusion Tensor Imaging -- Platform for managing medical data by using a passive electronic device -- Evaluation of a computerized cognitive screening tool (ADPS, Altoida) in a sample of community-dwelling older adults -- Interconnections and Modeling Schemes of Kinesia Paradoxa -- Knowledge Discovery on IoT-enabled mHealth Applications -- Computational approaches applied in the field of neuroscience -- Drugena: A fully automated immunoinformatics platform for the design of antibody drug conjugates against neurodegenerative diseases -- Brain-Computer Interface Design and Neurofeedback Training in the case of ADHD Rehabilitation -- Particular biomolecular processes as computing paradigms -- Decision trees and applications -- Utilization of new technologies in the production of pharmaceutical olive oil -- A survey of evolutionary games in biology -- DTCo: An ensemble SSL algorithm for X-rays classification -- Cognitive Enhancement and Brain-Computer Interfaces. Potential Boundaries and Risks -- Informatics and cognitive assessment: a RUDAS scale paradigm -- Effective stochastic algorithm in disease prediction -- A Systems Biology Approach for the Identification of Active Molecular Pathways during the Progression of Alzheimer’s Disease -- A brief survey of the Prisoners' Dilemma game and its potential use in biology -- Validation of modeling and simulation methods in computational biology -- An improved self-labeled algorithm for cancer prediction -- eHealth application for e-bloodanalysis, e-diagnosis and digital diet guidance -- Modeling the critical activation of chaperone machinery in protein folding -- ANTISOMA: A computational pipeline for the reduction of the aggregation propensity of monoclonal antibodies -- A microscale mathematical blood flow model for understanding cardiovascular diseases -- Blockchain For Mobile Health Applications Acceleration With GPU Computing -- Finite Size Effects in Networks of Coupled Neurons -- Detecting common pathways and key molecules of Neurodegenerative Diseases from the topology of molecular networks -- Robotic Systems involved in the diagnosis of Neurodegenerative diseases -- Undergraduate Students’ Brain Activity in Visual and Textual Programming -- Fuzzy logic Systems and Medical Applications -- Apache Spark Implementations for String Patterns in DNA Sequences -- Big Data Analysis and Genetic Liability to Neuropsychiatric Disease -- Mathematical models and computer simulation of chemical carninogenesis process and its inhibition by antocarcinogenic substances -- Transitioning knowledge levels through problem-solving methods -- Cellular phone user’s age or the duration of calls moderate autonomic nervous system? A meta-analysis -- Logical Analysis and Validation of Publications in Bioinformatics.
    Abstract: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people. .
    Type of Medium: Online Resource
    Pages: XIII, 508 p. 129 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030326227
    Series Statement: Advances in Experimental Medicine and Biology, 1194
    URL: https://doi.org/10.1007/978-3-030-32622-7
    DOI: 10.1007/978-3-030-32622-7
    DDC: 616.042
    Language: English
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  • 11
    Online Resource
    Online Resource
    Tissue-Specific Cell Signaling (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Human physiology. ; Cytology. ; Medicine Research. ; Biology Research. ; Medical Genetics. ; Human Physiology. ; Cell Biology. ; Biomedical Research.
    Description / Table of Contents: Preface -- Tissue-specific cell signaling: introduction -- Beyond the brain signaling -- Cell signaling within pituitary, the master gland of the endocrine system -- Cell signaling within endocrine glands: thyroid, parathyroids and adrenal glands -- Signaling pathways governing activation of innate immune cells -- Cell activation and signaling in lymphocytes -- Signaling pathways involved in kidney and urinary tract physiology and pathology -- More than androgens: hormonal and paracrine signaling in prostate development and homeostasis -- Testicular signaling: team work in sperm production -- Sperm signaling specificity: from sperm maturation until oocyte recognition -- Hormone signaling pathways in the postnatal mammary gland -- Oogenesis signaling: from development to environmental plasticity and aging -- Key signaling pathways in the cardiovascular system -- Growth factor signaling in the maintenance of adult lung homeostasis -- The signaling pathways involved in the regulation of skeletal muscle plasticity -- Adipocyte-specific signaling.
    Abstract: Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVIII, 436 p. 51 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030444365
    URL: https://doi.org/10.1007/978-3-030-44436-5
    DOI: 10.1007/978-3-030-44436-5
    DDC: 616.042
    Language: English
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  • 12
    Online Resource
    Online Resource
    Recent Advances in Biological Network Analysis : Comparative Network Analysis and Network Module Detection (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Bioinformatics. ; Medical genetics. ; Biotechnology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1: Global Alignment of PPI Networks -- Chapter 2: Integrated Network-Based Computational Analysis for Drug Development -- Chapter 3: Effective Random Walk Models for Comparative Network Analysis -- Chapter 4: Computational Methods for Protein-Protein Interaction Network Alignment -- Chapter 5: Network Propagation for the Analysis of Multi_Omics Data -- Chapter 6: Motifs in Biological Networks -- Chapter 7: Bio Fabric Visualization of Network Alignments -- Chapter 8: Module Identification of Biological Networks via Graph Partition -- Chapter 9: Network Module Detection to Decipher the Heterogeneity of Cancer Mutations.
    Abstract: This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights. .
    Type of Medium: Online Resource
    Pages: XII, 217 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571733
    URL: https://doi.org/10.1007/978-3-030-57173-3
    DOI: 10.1007/978-3-030-57173-3
    DDC: 660.6
    Language: English
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  • 13
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    Online Resource
    Frontotemporal Dementias : Emerging Milestones of the 21st Century (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Neurology . ; Medical genetics. ; Neuroscience. ; Neurology. ; Medical Genetics.
    Description / Table of Contents: 1. Behavioural variant FTD: recent advances in the diagnosis and understanding of the disorder -- 2. The neuropsychiatry of frontotemporal dementia -- 3. Nosology and Neuropathology of Language in Primary Progressive Aphasia -- 4. Measuring Behavior and Cognition in FTLD -- 5. Clinical update on C9orf72: FTD, ALS and beyond -- 6. Clinical aspects of familial FTLD associated with MAPT and GRN mutations -- 7. Neuroimaging in Frontotemporal Lobar Degeneration -- 8. The FTD Prevention Initiative - linking together genetic FTD cohort studies -- 9. Fluid Biomarkers of Frontotemporal Lobar Degeneration -- 10. Cross-cultural perspectives on frontotemporal degeneration -- 11. Clinical characteristics and Neuropathology of PSP, CBD and Related 4R-Tauopathies -- 12. Tau protein and frontotemporal dementias -- 13. FTLD-TDP pathological subtypes: clinical and mechanistic significance -- 14. Lysosomal dysfunction as a pathogenic mechanism in FTD: Evidence from PGRN and TMEM106B genetics and biology -- 15. Future trends in understanding the pathological role of TDP-43 and FUS proteins -- 16. Description of a new data resource for FTD including multiomic data on human post mortem brain (MAPT, GRN, C9orf72), matching mouse models and iPS models -- 17. Mendelian and sporadic FTD: avenues from genetics to disease pathways through in-silico prediction and modeling -- 18. FTLD treatment: Current Practice and Future Possibilities.
    Abstract: Under the name of Frontotemporal Dementias (FTD) numerous hereditary and sporadic disorders are listed. FTD may take away speech and language, social skills and ethical judgement, wishes and will, empathy and emotions; it may also impair motor functions. FTD may affect men and women in midlife or during old age leading to the demolition of the uniqueness of the human mind. In the last decade of the 20th century and in the first two decades of the 21st century, progress in the understanding of clinical, neuropathological, biochemical, and genetic aspects of FTD has accelerated. The novel awareness about FTD has directed young generations of researchers toward the study of this complex group of disorders. This Volume has been formulated with the participation of some of the leading scientists who have contributed to the development of knowledge in the clinical and basic science arenas. It captures the current central elements that are relevant to an up-to-date understanding of causes and pathogenesis of multiple forms of FTD. The volume is an opus that represents a distillation of the work of many scientists and addresses the current directions in the study of one of the most complex groups of diseases. In view of its structure, the book could also be used as a textbook, that offers both a broad and deep analysis of major areas in FTD. This book, planned by the International Society for Frontotemporal Dementias, is distinctive as it opens a window to a wide landscape about the biology of FTD. Thus, the book represents a moment of reflection on the present state of our knowledge of FTD and a collective vision toward scientific progress. The authors of each chapter share their knowledge and vision aimed at reducing the suffering which is caused by FTD.
    Type of Medium: Online Resource
    Pages: X, 320 p. 46 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030511401
    Series Statement: Advances in Experimental Medicine and Biology, 1281
    URL: https://doi.org/10.1007/978-3-030-51140-1
    DOI: 10.1007/978-3-030-51140-1
    DDC: 612.8
    Language: English
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  • 14
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    Online Resource
    Treasure Your Exceptions : The Science and Life of William Bateson (2022)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Medicine History. ; Life sciences. ; Biology Philosophy. ; Evolution (Biology). ; Biomaterials. ; Nucleic acids. ; Medical Genetics. ; History of Medicine. ; Life Sciences. ; Philosophy of Biology. ; Evolutionary Biology. ; Nucleic Acid.
    Description / Table of Contents: Abbreviations -- Prologue -- Part I. Genesis of a Geneticist -- 1 A Cambridge Childhood (1861-1882 -- 2 From Virginia to the Aral Sea (1883-1889) -- 3 Galton -- 4 Variation (1890-1894) -- 5 Romanes -- 6 Reorientation and Controversy (1895-1899) -- 7 What Life May Be -- Part II. Mendelism -- 8 Rediscovery (1900-1901) -- 9 Mendel’s Bulldog (1902-1906) -- 10 Bateson’s Bulldog -- 11 On Course (1907-1908) -- 12 Darwin Centenary (1909) -- 13 Chromosomes -- Part III. The Innes Years -- 14 Passages (1910-1914) -- 15 Eugenics -- 16 War (1915-1919) -- 17 My Respectful Homage (1920-1922) -- 18 Limits Undetermined (1923-1926) -- Part IV. Politics -- 19 Butler -- 20 Pilgrimages -- 21 Kammerer -- 22 Science and Chauvinism -- 23 Degrees for Women -- Part V. Eclipse -- 24 Bashing -- 25 Epilogue -- Part VI. Further Rediscovery -- 26 The Third Base -- 27 Mendel Basics -- 28 Romanes, Bateson, and Darwin's "Weak Point" -- 29 Bateson's Residue: Oligonucleotide Disharmony -- Publications of William Bateson -- References and Notes -- Acknowledgements -- Index.
    Abstract: William Bateson brought the work of Mendel (and much more) to the attention of the English-speaking world. He commanded the biological sciences in the decades after Darwin's death in 1882. To understand these years we must first understand Bateson. Through examination of the life of a major contributor to the turn-of-the-nineteenth-century revolution in biology, the authors reconcile the genocentrism of George Williams and Richard Dawkins with the hierarchical thinking of Richard Goldschmidt and Stephen Jay Gould. Aided by Rebecca Saunders, Bateson invented much of the basic terminology of modern genetics and, when addressing Darwin's great problem – the origin of species, introduced the mysterious term "the residue." While the first edition of this work (2008) related "residue" to relative concentrations of bases in DNA, the second edition reveals this as reflecting fundamental differences in short strings of bases. Thus, the book has come to represent not only Bateson’s science and life, but also a revised history of the biosciences that is likely to be increasingly visited, both by scientists and by those who wish to fully understand contemporary debates on racial, eugenic and gender aspects of genetics. In a nutshell, the book describes what we, in modern terms, would call a "colossal intelligence failure." Mendel handed it to us "on a plate" in 1865 when Bateson was only 4. It took 35 years to "join the dots" with Bateson a primary joiner. Shrugged off by many 20th century scientists as a freak "blip" in what was really an orderly advance, the Mendel episode was but one of a succession of such "blips." Thus, a multiplicity of post-Mendelian "Mendels" emerge as the story of Bateson's life unfolds. Peter Harper in Human Genetics (2009): "This book puts the record straight and one is left with a feeling of admiration for Bateson as both a scientist and a man, and with no doubt that he, more than anyone else, was largely responsible for the rapid progress in modern genetics during the first decade of the twentieth century." Michael J. Wade in Evolution (2009): "I strongly recommend this book for its information on an important central figure and for its bringing to life the several controversies at the origins of Genetics. It greatly illuminates the conceptual foundations of evolutionary genetics." Elof Axel Carlson in Quarterly Review of Biology (2009): "This volume will be of enormous benefit to historians of science who like to follow how ideas are born or die and why participants of different sides of each controversy held such rigid views of their own work and saw little merit in their competitor’s research." Joel S. Schwartz in Choice (2009): "This work includes key events in Bateson's career and is strengthened by discussion of the rediscovery of Mendelian principles by early 20th-century geneticists. Its basic premise is that Bateson was not merely one of the founders of genetics but played a pivotal role in the development of evolutionary biology by serving as the link between Victorian naturalists and early 20th-century biologists." Amitabh Joshi in Journal of Genetics (2010): "There is much in this book that I was not aware of, despite a formal training in genetics and a strong amateur interest in the history of biology.… It is certainly a book that any serious student of either genetics or evolution would greatly benefit from reading." .
    Type of Medium: Online Resource
    Pages: XXXIX, 688 p. 59 illus., 9 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030920999
    URL: https://doi.org/10.1007/978-3-030-92099-9
    DOI: 10.1007/978-3-030-92099-9
    DDC: 616.042
    Language: English
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  • 15
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    Regulatory Aspects of Gene Therapy and Cell Therapy Products : A Global Perspective (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Medical genetics. ; Genetics. ; Cell Biology. ; Medical Genetics. ; Clinical Genetics. ; Genetics.
    Description / Table of Contents: Introduction (MCG and FN) -- Updates on ATMP regulations from EU: experience with PRIME procedure and list of approved ATMP -- EU portal for clinical trials application -- European Pharmacopoeia texts on gene therapy medicinal products -- Updates on ATMP regulations from UK after Brexit and list of approved ATMP -- Updates on ATMP regulations from Switzerland and list of approved ATMP -- Updates on ATMP regulations from US FDA: experience with breakthrough/accelerated procedures and list of approved ATMP -- Updates on ATMP regulations from Canada and list of approved ATMP -- Updates on ATMP regulations from Brasil and list of approved ATMP -- Updates on ATMP regulations from Singapore and list of approved ATMP -- Updates on ATMP regulations from Japan: experience with new law and list of approved ATMP -- Updates on ATMP regulations from South Korea and list of approved ATMP -- Updates on ATMP regulations from Taiwan and list of approved ATMP -- Updates on ATMP regulations from Thailand and list of approved ATMP -- ATMP regulations in China and list of approved ATMP -- ATMP regulations in Australia and list of approved ATMP -- ATMP regulations in India and list of approved ATMP -- International harmonization programs. .
    Abstract: This book discusses the different regulatory pathways for Advanced Therapy Medicinal Products implemented by national agencies in North and South America, Europe and Asia and by international bodies in the effort of international harmonization. This book represents an update of the first edition, as it covers regulatory novelties and accumulated experience in the regions already addressed. In addition, this new edition offers a wider international perspective: new chapters are included covering Advanced Therapy Medicinal Products regulations in India, Malaysia, Spain and Thailand, the European Pharmacopoeia texts for gene therapy medicinal products as well as international harmonization programs. Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure and therapeutic use of these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of Advanced Therapy Medicinal Products in the areas of product quality, pharmacology and toxicology, clinical trial design and HTA pathways, as well as pertinent ‘must-know’ guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: a Global Perspective is part of the American Society of Gene & Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.
    Type of Medium: Online Resource
    Pages: IX, 242 p. 37 illus., 36 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031345678
    Series Statement: Advances in Experimental Medicine and Biology, 1430
    URL: https://doi.org/10.1007/978-3-031-34567-8
    DOI: 10.1007/978-3-031-34567-8
    DDC: 571.6
    Language: English
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  • 16
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    Taurine 12 : A Conditionally Essential Amino Acid (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Clinical biochemistry. ; Medical genetics. ; Human physiology. ; Proteins. ; Medical Biochemistry. ; Medical Genetics. ; Human Physiology. ; Proteins.
    Description / Table of Contents: 1. The disease-modifying role of taurine and its therapeutic potential in Coronavirus Disease 2019 (COVID-19) -- 2. Examination of taurine chloramine and taurine on LPS-induced acute pulmonary inflammation in mice -- 3. Synergism between taurine and dexamethasone in anti-inflammatory response in LPS-activated macrophages -- 4. Regulation of CXCR4 expression by taurine in macrophage-like cells -- 5. Taurine chloramine inhibits leukocyte migration by suppressing actin polymerization and extracellular signal regulated kinase -- 6. Taurine alleviates LPS-induced acute lung injury by suppressing TLR-4/NFKB pathway -- 7. Intervention effect of taurine on LPS-induced intestinal mechanical barrier injury in piglets -- 8. Current opinion on the therapeutic capacity of taurine containing halogen derivatives in infectious and inflammatory diseases -- 9. Taurine and N-bromotaurine in topical treatment of psoriasis -- 10. Taurine deficiency in tissues aggravates radiation-induced gastrointestinal syndrome -- 11. Taurine and its anti-cancer functions: In vivo and in vitro study -- 12. Taurine supplementation inhibits the expression of Atrogin-1 and MuRF-1, protein degradation marker genes, in skeletal muscle of C26-induced cachexia mouse model -- 13. Bioavailability of tauropine after oral ingestion in mouse -- 14. Taurine prevents liver injury by reducing oxidative stress and cytochrome c mediated apoptosis in broilers under low temperature -- 15. Effects of taurine on serum indexes of broilers with chronic heat stress -- 16. Antioxidant effect of taurine on chronic heat stressed broilers -- 17. Grading of Japanese diet intakes by 24-hour urine analysis of taurine and soy isoflavones in relation to cardiovascular risks -- 18. Perinatal taurine supplementation preserves the benefits of dynamic exercise training on cardiovascular and metabolic functions and prevents organ damage in adult male exercised rats -- 19. Impaired bile acid synthesis in a taurine-deficient cat model -- 20. Characterization of bone tissue and bone morphology in taurine transporter knockout mice -- 21. Blood taurine dynamics in captive lions: relationship with feed and bile acid composition -- 22. Taurine ameliorates apoptosis via Akt pathway in the kidney of diabetic rats -- 23. Taurine ameliorates oxidative stress in spinal cords of diabetic rats via Keap-Nrf2 signaling -- 24. Assessment of in vitro tests as predictors of the antioxidant effects of insulin, metformin and taurine in the brain of diabetic rats -- 25. Potential binding sites for taurine on the insulin receptor: A molecular docking study -- 26. Dietary protein modulates the efficacy of taurine supplementation on adaptive islet function and morphology in obesity -- 27. Taurine and exercise: Synergistic effects on adipose tissue metabolism and inflammatory processes in obesity -- 28. The taurine conjugated bile acid (TUDCA) normalizes insulin secretion in pancreatic b-cells exposed to fatty acids: Role of mitochondrial metabolism -- 29. Effect of taurine on the regulation of glucose uptake in skeletal muscle -- 30. Differences between physiological and pharmacological actions of taurine -- 31. Taurine and the brain -- 32. Electrophysiological evidence for anti-epileptic property of taurine -- 33. Observation of acupuncture effects on the expression of taurine transporter and taurine in the senescence-accelerated mouse brain: A pilot study -- 34. The regulatory effects of taurine on neurogenesis and apoptosis of neural stem cells in the hippocampus of rats -- 35. Brain-derived neurotrophic factor potentiates entorhinal-dentate but not hippocampus CA1 pathway in adult male rats: A mechanism of taurine-modulated BDNF on learning and memory -- 36. Influences of taurine pharmacodynamics and sex on active avoidance learning and memory -- 37. The effects of dietary taurine-containing jelly supplementation on cognitive function and memory ability of the elderly with subjective cognitive decline -- 38. Effects of dietary taurine-containing jelly supplementation on academic-related characteristics and academic achievement in Korean college entrance examinees: a pilot study -- 39. Improvement in willingness to purchase taurine-containing jelly needs high degrees of interest and preference: focused on Korean college students -- 40. Positive eusocial impacts on ants by taurine derivatives -- 41. Taurine prevents AFB1-induced renal injury by inhibiting oxidative stress and apoptosis -- 42. Taurine-derived compounds produce anxiolytic effects in rats following developmental lead exposure -- 43. Developmental lead exposure in rats causes sex-dependent changes in neurobiological and anxiety-like behaviors that are improved by taurine co-treatment -- 44. In vivo sex-dependent effects of perinatal Pb2+ exposure on pilocarpine-induced seizure susceptibility and taurine neuropharmacology -- 45. Taurine prevents LPS-induced liver injury in weaned piglets.
    Abstract: This volume gathers a selection of original articles and reviews on timely topics about the application of Taurine in human health written by members of the International Taurine Society, including COVID-19, cancer, heart disease, and diabetes, among others. Chapters are written by Taurine experts across the globe in North and South America, Asia, and Europe. A majority of the articles are based on original studies recently carried out in individual laboratories worldwide. The book is divided into eight parts, each covering a unique aspect of Taurine. Each section will highlight new research findings on Taurine and its application in various human systems, including the nervous system, immune system, and cardiovascular system, to combat disease. The first section covers COVID-19, the dominant health event of 2020. Experts will explore and clarify the potential therapeutic effectiveness of Taurine against COVID-19. The volume will promote further research into the application of Taurine in human health, and will be of use to a wide audience, including basic and clinical scientists, pharmaceutical and nutraceutical companies, and libraries. .
    Type of Medium: Online Resource
    Pages: XII, 518 p. 181 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030933371
    Series Statement: Advances in Experimental Medicine and Biology, 1370
    URL: https://doi.org/10.1007/978-3-030-93337-1
    DOI: 10.1007/978-3-030-93337-1
    DDC: 612.015
    Language: English
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  • 17
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    Anticipatory Ethics and The Use of CRISPR in Humans (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Medical genetics. ; Biotechnology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1: Brief Introduction to CRISPR Cas 9 -- Chapter 2: Introduction To Anticipatory Ethics -- Chapter 3: CRISPR, Phenomenology and Lived Experience -- Chapter 4: CRISPR and the Concept of Personhood -- Chapter 5: The use and access to CRISPR in historically socio-economically disadvantaged and marginalized communities -- Chapter 6: Future use of CRISPR: Gene Drive -- Chapter 7: Future use of CRISPR II: CRISPR Kill Switches -- Chapter 8: Domestic and International Regulation of CRISPR -- Chapter 9: Policy Recommendations with respect to CRISPR Germline Editing in Humans -- Chapter 10: Conclusions.
    Abstract: Can we move forward with the use of CRISPR in humans without a well-formed policy and ethical framework to support it? In this new book, neuroscientist Michael W. Nestor and philosopher Richard Wilson argue that the answer is a resounding “no.” Does an ethical and policy program need to be restrictive concerning the use of CRISPR in humans? Nestor and Wilson argue that, although the future of gene editing in humans is inevitable using CRISPR technologies, the scientific, policy, ethics, and clinical communities must work together to provide the necessary frameworks to help CRISPR flourish as an essential tool to treat human disease. To achieve the most inclusive, equitable, and ethically sound use of CRISPR in humans, the scientific/policy/clinical community must involve the most comprehensive set of stakeholders possible, including the lay public. This book sets a framework for shared understanding and discussion across disciplines with an appeal to scientists and non-scientists alike. The authors urge all stakeholders to engage in active dialogue about the appropriate context for using CRISPR and other gene-editing technologies in humans. It provides policy analysis and recommendations for assuring the most inclusive, equitable, and ethically sound use of CRISPR in humans, exploring its positive potential to treat mental disorders and the potential to induce other cognitive enhancements.
    Type of Medium: Online Resource
    Pages: XIX, 145 p. 13 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030983680
    URL: https://doi.org/10.1007/978-3-030-98368-0
    DOI: 10.1007/978-3-030-98368-0
    DDC: 660.6
    Language: English
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  • 18
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    Online Resource
    Progress in Heritable Soft Connective Tissue Diseases (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Physiology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Physiology. ; Internal Medicine.
    Description / Table of Contents: Basic structure, physiology and biochemistry of connective tissues and extracellular matrix collagens -- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life -- Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins -- Proteoglycans and Diseases of Soft Tissues -- Growth Factor Roles in Soft Tissue Physiology and Pathophysiology -- Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling -- The Pathophysiology and Pathogenesis of Marfan Syndrome -- Ehlers-Danlos syndromes, joint hypermobility and hypermobility spectrum disorders -- Ehlers–Danlos Syndrome Associated with Glycosaminoglycan Abnormalities -- Loeys-Dietz Syndrome -- Meester-Loeys syndrome -- Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Elastic Fiber Homeostasis -- Collagen VI Muscle Disorders: Mutation Types, Pathogenic Mechanisms and Approaches to Therapy -- Connective Tissue Disorders in Domestic Animals.
    Abstract: This volume represents a substantially revised and updated 2nd edition of a reference handbook on major structural components of soft connective tissues and a whole slew of heritable diseases of soft connective tissues. The number of clearly identifiable and distinct disorders has grown somewhat since the 1st edition in 2014, e.g., Ehlers-Danlos syndrome has now 13 entities. A brand new syndrome, Meester Loeys syndrome carrying the name of Bart Loeys was added as a companion to Loeys-Dietz syndrome. Numerous variations of cutis laxa and joint mobility disorders have been discovered taking advantage of recent advancements in genetic analysis. We have acquired better understanding of pathogenesis and biochemical changes in some other, more established entities, such as Marfan and collagen VI myopathies where better management and possible treatment are on the horizon. Even in the case of connective tissue diseases in domestic animals some progress has been made. All these updates were contributed by a group of distinguished and preeminent physicians and scientists, all of them not just working in the field but making new discoveries described by them. Readers will notice that seemingly there is an overlap among many of these disorders. And indeed, many of them, if not most are interconnected because of the prominent roles of TGFβ, of fibrillin microfibrils and collagen fibril assembly (and other molecules) playing in connective tissues physiology, and by extension in pathogenesis of many disorders described in the book. What I found particularly helpful that author(s) of each chapter bring their own perspective even when described closely related mechanism of the disease. These observations should help with diagnosis and management of such cases. The first chapters are more general, concentrating more on the physiology, structure and biochemistry of normal soft tissues. That should help in better understanding of the pathophysiology. Last but not least, the chapters are very readable, more like detective stories than dry description of genetic/biochemical defects. I do hope that basic scientists and clinicians with similar and diverse interests alike will appreciate this volume and will be inspired by it to develop their research in the field.
    Type of Medium: Online Resource
    Pages: IX, 343 p. 1 illus. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030806149
    Series Statement: Advances in Experimental Medicine and Biology, 1348
    URL: https://doi.org/10.1007/978-3-030-80614-9
    DOI: 10.1007/978-3-030-80614-9
    DDC: 610.72
    Language: English
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  • 19
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    Online Resource
    GeNeDis 2020 : Geriatrics (2021)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Stratification of patients with Chronic Obstructive Pulmonary Disease using Volatile Organic Compounds -- 2-Evidence-based Leadership: A Study of its Application to General Hospital of the Public Health System through the Implementation Leadership Scale -- 3-Greek nurses’ perception of hospital ethical climate. A cross-sectional study -- 4-Investigating the main causes of conflicts and the managements strategies are used by healthcare professionals. The case of general hospital of Arta -- 5-Incidence of deep vein thrombosis and its effect on health related quality of life among nurses of Greek public hospital. A multicenter study -- 6-Factors affecting anxiety and depression in caregivers of hemodialysis patients -- 7-Hand grip strength in patients on hemodialysis: An observational study -- 8-The effect of spirituality on illness perceptions in patients undergoing hemodialysis -- 9-Validation of the STOP-Bang Questionnaire in Greek patients suffering from obstructive sleep apnea -- 10-The role of Pythagorean Self-Awareness Intervention in obstructive sleep apnea. A randomized controlled trial -- 11-Tissue characterization in Cardiology. Moving beyond function -- 12-Psychiatric care in acute care units with locked doors: Nursing care providers’ perceptions and experiences -- 13-Researching nursing students’ attitudes towards mental health practice: cultural adaptation and validation of the Greek version of the Acceptability of Locking the Door Questionnaire in acute psychiatric care -- 14-Compliance of bronchial asthma patients' with the Mediterranean diet -- 15-Nurses’ experiences of psychiatric care in acute care units with an open door policy -- 16-Validation of the Greek Version of Hedonic, Eudaimonic and Extrinsic Motives for Activities (HEEMA) Instrument -- 17-Event-Related Rumination Inventory: A Validation Process in the Greek Language -- 18-The job rotation of nursing staff and its effects on nurse`s satisfaction and occupational engagement -- 19-The burden on carers with multiple sclerosis -- 20-Attitudes of the general population regarding patient information for a chronic and life-threatening disease. A cross-sectional study -- 21-Assessment of healthcare professionals’ knowledge and awareness on aspects related to ionizing radiation examinations in Athens, Greece -- 22-Medication errors and their correlation with nurse's satisfaction. The case of the hospitals of Lasithi, Crete -- 23-Health-Related Quality of Life and Living Costs of HIV-Infected Patients -- 24-Evaluation of anxiety and depression in women undergoing mastectomy in Greece -- 25-The effect of emotional intelligence on caring behaviors among psychiatric nurses in Greece -- 26-Investigating nursing leadership in intensive care units of hospitals of Northern Greece and its relationship to the working environment -- 27-Health-Related Quality of Life and Rehabilitation Costs of Patients with Amputated Limb -- 28-Anxiety and depression in hemodialysis: Sex differences -- 29-Patient knowledge, adherence to the therapeutic regimen, and quality of life in hemodialysis -- 30-The burden of caregivers of patients after hip replacement and its impact on the cost of living of the family -- 31-The effects of exercise in patients with Sarcopenia -- 32-Fluid dynamics derived parameters in coronary vessels -- 33-Level of knowledge about COPD among patients and caregivers -- 34-Increased body mass index (BMI) and sunscreen use are associated with inadequate vitamin D status in Greek adults in winter -- 35-The effect of whole-body cryostimulation in healthy adults -- 36-Exhaled Nitric Oxide (FeNO) in patients hospitalized for an exacerbation of bronchiectasis and/or COPD -- 37-Formulation and Evaluation of Dermatological product containing Niacinamide -- 38-Exhaled breath condensate and dyspnea in COPD -- 39-The Effects of Pythagorean Self-Awareness Intervention on Irritable Bowel Syndrome Patients: A Non-Randomized Controlled Trial -- 40-Adults’ stress response to unexpected oral and arithmetic tasks in supine position -- 41-Triangles and family engagement in drug and alcohol addiction treatment -- 42-Use of fortified bread for addressing vitamin D deficiency. .
    Abstract: The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The increase in the average length of life leads to the development of various diseases in the elderly population. This volume focuses on the sessions from the conference on Geriatrics.
    Type of Medium: Online Resource
    Pages: XXVII, 389 p. 27 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030787714
    Series Statement: Advances in Experimental Medicine and Biology, 1337
    URL: https://doi.org/10.1007/978-3-030-78771-4
    DOI: 10.1007/978-3-030-78771-4
    DDC: 616.042
    Language: English
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  • 20
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    Gadd45 Stress Sensor Genes (2022)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Microbial genetics. ; Medical Genetics. ; Medical Genetics. ; Microbial Genetics.
    Description / Table of Contents: GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis -- GADD45 in Development and Cancer -- GADD45 in Normal Hematopoiesis and Leukemia -- GADD45 in DNA Methylation and DNA Repair -- GADD45 Proteins in Immunity -- GADD45 in Liver Function and Cancer -- GADD45 in Pre-Eclampsia -- GADD45 in Senescence -- GADD45 in Neuronal Development, Function, and Injury -- Index.
    Abstract: This second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors. The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved.
    Type of Medium: Online Resource
    Pages: IX, 153 p. 27 illus., 18 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030948047
    Series Statement: Advances in Experimental Medicine and Biology, 1360
    URL: https://doi.org/10.1007/978-3-030-94804-7
    DOI: 10.1007/978-3-030-94804-7
    DDC: 616.042
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  • 21
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    Online Resource
    RNA Structure and Function (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biomolecules. ; Physical biochemistry. ; Macromolecules. ; Biochemistry. ; Medical genetics. ; Cytology. ; Genetics. ; Structural Biology. ; Biochemistry. ; Medical Genetics. ; Cell Biology. ; Genetics and Genomics.
    Description / Table of Contents: 1. Computational Tools for Functional Analysis of Circular RNAs -- 2. The Hidden Layer of RNA Variants -- 3. Functional Role of Non-Coding RNAs in Prostate Cancer: From Biomarker to Therapeutic Targets -- 4. The structure, function, and modification of non-coding RNAs in cardiovascular system,- 5. Contribution of RNA Species in Sexually Transmitted Infections -- 6. Hypoxia and Epithelial-to-Mesenchymal Transition (EMT) in Cancer: A Non-Coding RNA Perspective -- 6. A Study on the Role of piRNAs in Cancer Epigenetics -- 7. Modified Nucleosides as RNA Components. Structure, Biological Role and Drug Design -- 8. Multifaceted Functions of RNA m6A Modification in Modulating Regulated Cell Death -- 9. Incorporation of Pseudouridine into RNA for Biochemical and Biophysical Studies -- 10. Molecular Dynamics Simulations of Chemically Modified Ribonucleotides.
    Abstract: This book focuses on the current status of our understanding of RNA, a key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA, noncoding RNAs, modified nucleosides, and RNA enzymes. The different chapters detail methods to investigate RNA structure and function, the chemistry of modified RNAs, and the latest advances in our understanding of the vast array of biological processes in which RNA is involved. RNA, in one form or another, touches almost everything in a cell. RNA has both structural and catalytic properties. RNA fulfills a broad range of functions. These molecules are no longer seen as passive elements transferring the genetic information from DNA into proteins but regulate the activity of genes during development, cellular differentiation, and changing environments. RNAs are involved in various aspects of cell physiology and disease development. Discoveries of RNA with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as both the source and countermeasure to cancer or severe viral infection, stimulate new trends, passion, and solutions for molecular medicine. In this book, fundamental questions about the biochemical and genetic importance of RNA, how mRNAs are generated and used to produce proteins, how noncoding and catalytic RNAs mediate key cellular processes, how to determine RNA structure and how to apply RNA in treatment of diseases. This book is an essential resource for researches in academia and industry contributing to the development of new RNA therapeutics. The book is geared toward scientists from the graduate level on up and particularly appeals to active investigators in RNA biology, molecular biology, and biochemistry.
    Type of Medium: Online Resource
    Pages: XI, 666 p. 134 illus., 123 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031363900
    Series Statement: RNA Technologies, 14
    URL: https://doi.org/10.1007/978-3-031-36390-0
    DOI: 10.1007/978-3-031-36390-0
    DDC: 572.8
    Language: English
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    The Unedited : A Novel About Genome and Identity (2020)
    Cham :Springer International Publishing :
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    Keywords: Life sciences. ; Medical sciences. ; Medical genetics. ; Ethics. ; Evolution (Biology). ; Life Sciences. ; Health Sciences. ; Medical Genetics. ; Moral Philosophy and Applied Ethics. ; Evolutionary Biology.
    Description / Table of Contents: Part 1: The wall -- The day of the readings -- Transit interviews -- The truth will set you free -- Part 2: Home -- Unrest -- The witch -- Business acumen -- Father Marius -- Peas and politics -- Part 3: Return -- Safe haven -- Summer rain -- Part 4: Scientific Appendix. Manipulating the Human Genome: Technology and Choice.
    Abstract: This novel is set in the near future, where human genome editing has become routine. First adopted to fight a lethal virus, it is now widely used to prevent diseases and favor other traits. Ben, Eiko, Celia, Raphael and Leo have just had their coming-of-age genome reading and are struggling with this new information for each their own reasons. Soon, they are cast into the middle of a crisis that threatens the future of their society and pits it against a parallel, but strictly separated, society where genome manipulation is forbidden on religious grounds. The book includes an essay on the potential of human genome engineering and related genome-based choices.
    Type of Medium: Online Resource
    Pages: VI, 250 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030346249
    Series Statement: Science and Fiction,
    URL: https://doi.org/10.1007/978-3-030-34624-9
    DOI: 10.1007/978-3-030-34624-9
    DDC: 570
    Language: English
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  • 23
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    Advances in Precision Nutrition, Personalization and Healthy Aging (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Nutrition   . ; Aging. ; Medical genetics. ; Nutrition. ; Ageing. ; Medical Genetics.
    Description / Table of Contents: Foreword -- 1. Trends in personalised precision nutrition, Objectives -- 2. Individualization, precision nutrition developments for the 21st Century -- 3. Precision nutrition from the view of genetics and epigenetics -- 4. Precision Nutrition fromThe View of the Gut Microbiome -- 5. Personalised nutrition for healthy aging, a review -- 6. Precise Nutrition and Metabolic Syndrome, remodeling the Microbiome with Polyphenols, Probiotics and Postbiotics -- 7. Precision nutrition and metabolomics, a model of Alzheimer’s Disease -- 8. Precision nutrition and cognitive decline -- 9. Algorithms for the analysis of markers in personalized health care -- 10. Precise Nutrition and Functional Foods -- 11. Precision nutrition from a practical clinical view, a case study -- 12. Translational aspects in Precision Nutrition, Personalization, Bio-Markers and Healthy Aging.
    Abstract: This book provides an overview on current trends and developments in precision nutrition and personalized health preservation, focussing on a field which is undergoing rapid change. Today, personalized strategies contrast generally accepted guidelines for specified groups and improved health and disease markers are shifting health care toward preventive strategies. At the same time, advances in food additives, nutraceuticals, functional, and medical foods are breaking down the traditional domains of health-related disciplines. This book aims to provide an overview on these processes, discusses arising problems, and provides an outlook on the future of personalized health care and the role of precision nutrition. It covers preliminary thoughts on what has been achieved and focusses on developments in the area of metabolic diseases, aging, and neurology. The book is intended as a primer in the field of precision nutrition and is aimed at researchers, clinicians, and students in health-related disciplines, who would like to get insights into current trends and developments in this area.
    Type of Medium: Online Resource
    Pages: VIII, 299 p. 99 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031101533
    URL: https://doi.org/10.1007/978-3-031-10153-3
    DOI: 10.1007/978-3-031-10153-3
    DDC: 613.2
    Language: English
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  • 24
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    DNA Methyltransferases - Role and Function (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cytology. ; Epigenetics. ; Medical genetics. ; Enzymology. ; Cell Biology. ; Epigenetics. ; Medical Genetics. ; Enzymology.
    Description / Table of Contents: Chapter 1. Mechanisms and biological roles of DNA methyltransferases and DNA methylation – from past achievements to future challenges -- Chapter 2.Bacterial DNA Methylation and Methylomes -- Chapter 3. ChapterDomain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases -- Chapter 4. Enzymology of Mammalian DNA Methyltransferases -- Chapter 5. Genetic Studies on Mammalian DNA Methyltransferase -- Chapter 6. Structure and Mechanism of Plant DNA Methyltransferases -- Chapter 7. DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics -- Chapter 8. N6-Methyladenine: A Conserved and Dynamic DNA Mark -- Chapter 9. Pathways of DNA Demethylation -- Chapter 10. Structure and Function of TET Enzymes -- Chapter 11.Proteins That Read DNA Methylation -- Chapter 12. Recent advances on DNA base flipping – a general mechanism for writing, reading, and erasing DNA modifications.-Chapter 13. The Role of DNA Methylation in Cancer -- Chapter 14. DNMTs and DNA damage -- Chapter 15. Role of DNMTs in brain -- Chapter 16. Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.-Chapter 17. Inhibitors of DNA methylation -- Chapter 18. Rewriting DNA Methylation Signatures at Will: The Curable Genome Within Reach? -- Chapter 19. DNA Labeling Using DNA Methyltransferases.
    Abstract: This 2nd edition of the book on DNA methyltransferases has been comprehensively updated to reflect many novel research findings regarding the structure, function, and technology of these enzymes that have emerged over the past 6 years. As the previous edition, this 2nd edition explains the biochemical properties of DNA methyltransferases, describing their structures, mechanisms and biological roles in bacteria, humans and plants. It also discusses the biological processes of reading DNA methylation and the mechanisms of DNA demethylation. This volume highlights the newest findings on DNA methyltransferase inhibitors and their use in cancer therapy as well as the latest epigenome editing systems based on these enzymes. Overall, this 2nd edition comprehensively summarizes the current state of research in the field of DNA methylation and DNA methyltransferase and is essential reading for early career and advanced researchers in this exciting field.
    Type of Medium: Online Resource
    Pages: IX, 562 p. 1 illus. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783031114540
    Series Statement: Advances in Experimental Medicine and Biology, 1389
    URL: https://doi.org/10.1007/978-3-031-11454-0
    DOI: 10.1007/978-3-031-11454-0
    DDC: 571.6
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    Human Chromosome Atlas : Introduction to Diagnostics of Structural Aberrations (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Diagnosis. ; Chromosomes. ; Genetic disorders. ; Genetic counseling. ; Medical Genetics. ; Diagnosis. ; Chromosomes. ; Genetic Service.
    Description / Table of Contents: Introduction: Social Attitude towards Disabled People in Different Areas and Cultures -- Role of Ethics Committees -- International Quality Control in the Field of Diagnostics -- Structural Chromosom Abarrations -- Mutations in Non-coding DNA Regions. Single Case Presentations of Intrachromosomal Rearrangements: Inversions -- Deletions -- Duplications -- Ring Chromosomes -- Isochromosomes. Single Case Presentations of Interchromosomal Rearrangements: Translocations -- Insertions -- Complex Chromosome Rearrangements (CCR) -- Marker Chromosomes -- Cases of Intra- and Interchromosomal Mutation in Polymorphic Regions. Guidelines to Clinical Questions and Practical Approaches: Genetic Counselling Procedures -- Life of Persons with Chromosomal Disorders -- Support Groups for Chromosomal Disorders -- Diagnosis and Therapy -- Outlook.
    Abstract: Now in its second edition, this atlas serves as an easy-to-use diagnostic guide for the analysis of the human karyotype. Split in four parts, it starts with a comprehensive introduction covering the molecular cytogenetic basics, the role of ethic committees and international quality control in the field of diagnostics. The main parts II and III, demonstrate the spectrum of the different types of chromosome abnormalities by a combination of karyogram and ideogram, it compares the expressiveness of different banding techniques, and it gives the karyotype formula and describes morphological peculiarities of each presented case. The final part, provides a detailed description of variants of non-coding DNA and focuses on potential problems in detecting aberrations and mentions necessary additional investigations and peculiarities, which have to be taken into account when counseling carriers of a chromosome aberration or their relatives. Given its comprehensive scope and practical approach, this atlas is an indispensable resource for researchers, clinicians and practitioners working in the field of cytogenetics and clinical genetics.
    Type of Medium: Online Resource
    Pages: XI, 388 p. 98 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031105883
    URL: https://doi.org/10.1007/978-3-031-10588-3
    DOI: 10.1007/978-3-031-10588-3
    DDC: 616.042
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    Ferroptosis: Mechanism and Diseases (2021)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Cytology. ; Lipids. ; Biomedical Research. ; Medical Genetics. ; Cell Biology. ; Cell Biology. ; Lipidology.
    Description / Table of Contents: Foreword -- Ferroptosis: Concepts and Definitions -- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors -- Iron Homeostasis and Metabolism: Two Sides of a Coin -- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis -- Emerging Role for Ferroptosis in Infectious Diseases -- Small Molecule Regulators of Ferroptosis -- Necroptosis, The other main Caspase-Independent Cell Death.
    Abstract: This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis. While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.
    Type of Medium: Online Resource
    Pages: IX, 140 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030620264
    Series Statement: Advances in Experimental Medicine and Biology, 1301
    URL: https://doi.org/10.1007/978-3-030-62026-4
    DOI: 10.1007/978-3-030-62026-4
    DDC: 610.72
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    GeNeDis 2018 : Geriatrics (2020)
    Cham :Springer International Publishing :
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    Keywords: Neurosciences. ; Medical genetics. ; Neuroscience. ; Medical Genetics.
    Description / Table of Contents: A hypothesis of circulated microRnas implication in high incidence of atrial fibrillation and other electrocardiographic abnormalities in cancer patients -- Central Line-associated Bloodstream Infections (CLABSI) Incidence and the role of obesity: a prospective, observational study in Greece -- Number of brain states in an N-body dynamical scenario according to the universal Bekenstein entropy bound -- Burden and sleeping disorders of family caregivers of Hemodialysis patients with Chronic Kidney Disease-End Stage. A cross-sectional study -- Quality of life in type 2 diabetes mellitus patients with neuropsychological deficits -- A framework for assessing the impact of information seeking behavior on cancer patients’ long-term prognosis -- Sleeping Disorders and Health Related Quality of Life in Hemodialysis patients with Chronic Renal Disease in Greece -- Subjective Quality of Life, Religiousness and Spiritual Experience in Greek Orthodox Christians: Data from Healthy Aging and Patients with Cardiovascular Disease -- Mini-Mental State Examination: Greek normative data stratified by age and education in a large sample of 925 community-dwelling healthy participants -- The role of the family in the care of Alzheimer patients -- Prevalence of Stroke Cases in Warangal, Telangana Region, India: A Hospital-Based Case Study -- Compliance of Patients with Acute Coronary Syndrome with treatment following their hospitalization from the Cardiac Coronary Unit -- Using a Virtual Reality Serious Game to Assess the Performance of Older Adults with Frailty -- Characteristics and survival rates in ward patients requiring evaluation by Intensivist in Greece.
    Abstract: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people.
    Type of Medium: Online Resource
    Pages: X, 155 p. 10 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030326371
    Series Statement: Advances in Experimental Medicine and Biology, 1196
    URL: https://doi.org/10.1007/978-3-030-32637-1
    DOI: 10.1007/978-3-030-32637-1
    DDC: 612.8
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    GeNeDis 2022 : Molecular, Chemical, and Cellular Biology (2023)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Stratification of patients with Chronic Obstructive Pulmonary Disease using Volatile Organic Compounds -- 2-Evidence-based Leadership: A Study of its Application to General Hospital of the Public Health System through the Implementation Leadership Scale -- 3-Greek nurses’ perception of hospital ethical climate. A cross-sectional study -- 4-Investigating the main causes of conflicts and the managements strategies are used by healthcare professionals. The case of general hospital of Arta -- 5-Incidence of deep vein thrombosis and its effect on health related quality of life among nurses of Greek public hospital. A multicenter study -- 6-Factors affecting anxiety and depression in caregivers of hemodialysis patients -- 7-Hand grip strength in patients on hemodialysis: An observational study -- 8-The effect of spirituality on illness perceptions in patients undergoing hemodialysis -- 9-Validation of the STOP-Bang Questionnaire in Greek patients suffering from obstructive sleep apnea -- 10-The role of Pythagorean Self-Awareness Intervention in obstructive sleep apnea. A randomized controlled trial -- 11-Tissue characterization in Cardiology. Moving beyond function -- 12-Psychiatric care in acute care units with locked doors: Nursing care providers’ perceptions and experiences -- 13-Researching nursing students’ attitudes towards mental health practice: cultural adaptation and validation of the Greek version of the Acceptability of Locking the Door Questionnaire in acute psychiatric care -- 14-Compliance of bronchial asthma patients' with the Mediterranean diet -- 15-Nurses’ experiences of psychiatric care in acute care units with an open door policy -- 16-Validation of the Greek Version of Hedonic, Eudaimonic and Extrinsic Motives for Activities (HEEMA) Instrument -- 17-Event-Related Rumination Inventory: A Validation Process in the Greek Language -- 18-The job rotation of nursing staff and its effects on nurse`s satisfaction and occupational engagement -- 19-The burden on carers with multiple sclerosis -- 20-Attitudes of the general population regarding patient information for a chronic and life-threatening disease. A cross-sectional study -- 21-Assessment of healthcare professionals’ knowledge and awareness on aspects related to ionizing radiation examinations in Athens, Greece -- 22-Medication errors and their correlation with nurse's satisfaction. The case of the hospitals of Lasithi, Crete -- 23-Health-Related Quality of Life and Living Costs of HIV-Infected Patients -- 24-Evaluation of anxiety and depression in women undergoing mastectomy in Greece -- 25-The effect of emotional intelligence on caring behaviors among psychiatric nurses in Greece -- 26-Investigating nursing leadership in intensive care units of hospitals of Northern Greece and its relationship to the working environment -- 27-Health-Related Quality of Life and Rehabilitation Costs of Patients with Amputated Limb -- 28-Anxiety and depression in hemodialysis: Sex differences -- 29-Patient knowledge, adherence to the therapeutic regimen, and quality of life in hemodialysis -- 30-The burden of caregivers of patients after hip replacement and its impact on the cost of living of the family -- 31-The effects of exercise in patients with Sarcopenia -- 32-Fluid dynamics derived parameters in coronary vessels -- 33-Level of knowledge about COPD among patients and caregivers -- 34-Increased body mass index (BMI) and sunscreen use are associated with inadequate vitamin D status in Greek adults in winter -- 35-The effect of whole-body cryostimulation in healthy adults -- 36-Exhaled Nitric Oxide (FeNO) in patients hospitalized for an exacerbation of bronchiectasis and/or COPD -- 37-Formulation and Evaluation of Dermatological product containing Niacinamide -- 38-Exhaled breath condensate and dyspnea in COPD -- 39-The Effects of Pythagorean Self-Awareness Intervention on Irritable Bowel Syndrome Patients: A Non-Randomized Controlled Trial -- 40-Adults’ stress response to unexpected oral and arithmetic tasks in supine position -- 41-Triangles and family engagement in drug and alcohol addiction treatment -- 42-Use of fortified bread for addressing vitamin D deficiency. .
    Abstract: The 5th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Molecular Biology, Chemical Biology, and Cellular Biology.
    Type of Medium: Online Resource
    Pages: XVIII, 319 p. 137 illus., 132 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031319785
    Series Statement: Advances in Experimental Medicine and Biology, 1423
    URL: https://doi.org/10.1007/978-3-031-31978-5
    DOI: 10.1007/978-3-031-31978-5
    DDC: 616.042
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    Voltage-gated Ca2+ Channels: Pharmacology, Modulation and their Role in Human Disease (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Medical genetics. ; Human physiology. ; Pharmacology. ; Medical Genetics. ; Human Physiology.
    Description / Table of Contents: Preface -- Part 1 Modulation -- Cav1.1Calcium Channel Signaling Complexes in Excitation–Contraction Coupling: Insights from Channelopathies -- Mechanisms of Vascular CaV1.2 Channel Regulation During Diabetic Hyperglycemia -- Sympathetic Nervous System Regulation of Cardiac Calcium Channels -- Modulation of CaV1.2 Channel Function by Interacting Proteins and Post-Translational Modifications: Implications in Cardiovascular Diseases and COVID-19 -- Part 2 Pharmacological Approaches -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits -- Design and Applications of Genetically-Encoded Voltage-Dependent Calcium Channel Inhibitors -- Part 3 Disease insight from channelopathies: consequences for pharmacology and therapeutic strategies -- CACNA1C-Related Channelopathies -- CACNA1D-Related Channelopathies: From Hypertension to Autism -- CACNA1A-Related Channelopathies: Clinical Manifestations and Treatment Options -- CaV3.2 (CACNA1H) in Primary Aldosteronism,- CaV3.3 Channelopathies -- Pathophysiological Roles of Auxiliary Calcium Channel α2δ Subunits.
    Abstract: The aim of this volume is to summarize novel findings on the function, pathophysiology, and regulation of voltage-gated Ca2+ channels and on novel concepts of their pharmacological modulation. Impressive insights into the role of channel function and regulation have come from Ca2+ channelopathies affecting the pore-forming as well as accessory subunits and channel-interacting proteins. Moreover, the long-sought molecular basis for key regulatory pathways have been discovered as well as exciting concepts of their subtype-selective pharmacological modulation.
    Type of Medium: Online Resource
    Pages: XII, 316 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031384370
    Series Statement: Handbook of Experimental Pharmacology, 279
    URL: https://doi.org/10.1007/978-3-031-38437-0
    DOI: 10.1007/978-3-031-38437-0
    DDC: 615
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    The Immunogenetics of Dermatologic Diseases (2022)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Immunology. ; Dermatology. ; Biomedical Research. ; Medical Genetics. ; Immunology. ; Biomedical Research. ; Dermatology.
    Description / Table of Contents: Genetics control of immune responses -- Non-melanoma skin cancer -- Melanoma -- Psoriasis -- Atopic dermatitis -- Contact dermatitis -- Lichen planus -- Pemphigus and pemphigoids -- Morphea and Lichen Sclerosus -- Granuloma annulare and Necrobiosis lipoidica -- Alopecia areata -- Vitiligo -- Acne Vulgaris and Rosacea -- Urticaria and Angioedema -- Cutaneous drug reaction -- Photodermatologic disorders -- Infantile Haemangioma and other vascular malformations.
    Abstract: This book intends to investigate the broad spectrum of genetic changes in immunological processes involved in cutaneous diseases. One of the main goals of immunogenetic studies is finding susceptibility genes for complex diseases. This can provide an insight into the pathogenesis of the condition in a way that is not easily achievable through other kinds of studies. Thus they are a rational initial step for generating hypotheses about disease pathogenesis. This may especially benefit dermatology, a field notorious for having too many diseases with unknown etiologies. Immunogenetic investigations have made targeted treatment strategies possible for diseases such as psoriasis and pemphigus. Even though these strategies have revolutionized the management of chronic dermatological conditions such as psoriasis, still there are a lot of unanswered questions. For instance, psoriasis patients respond very differently to each of the commercially available biological agents. This diversity could be partially explained by the differences in the sets of genes responsible for disease induction in each individual. Thus whole genome sequencing strategies, if feasible at individual levels, might help in tailoring these targeted treatments based on specific genetic backgrounds. Our intention in preparing this book was to explore the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. We have tried to cover most areas of dermatology where enough studies were available to gather a chapter. Still, there is a substantial lack of knowledge on the immunogenetics of many dermatological conditions. We hope that this book would encourage the investigators to fill these gaps of knowledge.
    Type of Medium: Online Resource
    Pages: XXI, 450 p. 64 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030926168
    Series Statement: Advances in Experimental Medicine and Biology, 1367
    URL: https://doi.org/10.1007/978-3-030-92616-8
    DOI: 10.1007/978-3-030-92616-8
    DDC: 610.72
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    Cell Biology and Translational Medicine, Volume 8 : Stem Cells in Regenerative Medicine (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Stem cells. ; Regenerative medicine. ; Medical genetics. ; Biotechnology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Clinical Genetics. ; Chemical Bioengineering.
    Description / Table of Contents: The future of stem cell research and its clinical translation in Canada: Exploring questions of governance and policy options -- Future cell and gene therapy for osteoarthritis (OA): potential for using mammalian protein production platforms, irradiated and transfected protein packaging cell lines for over-production of therapeutic proteins and growth factors -- The Horizon of Gene Therapy in Modern Medicine: Advances and Challenges -- Developments in Artificial Platelet and Erythroid Transfusion Products -- Advancing mesenchymal stem cell therapy with CRISPR/Cas9 for clinical trial studies -- Mesenchymal Stem Cells in Asthma -- Oocyte Aging: the Role of Cellular and Environmental Factors and Impact on Female Fertility -- Targeting Cancer Metabolism and Cell Cycle by Plant-derived Compounds -- Differentiation potential of Mesenchymal Stem Cells into Pancreatic β-Cells -- Zooming in across the Skin: A Macro-to-Molecular Panorama.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the eight volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 203 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030458935
    Series Statement: Cell Biology and Translational Medicine, 1247
    URL: https://doi.org/10.1007/978-3-030-45893-5
    DOI: 10.1007/978-3-030-45893-5
    DDC: 571.6
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    Mammalian Sterols : Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids (2020)
    Cham :Springer International Publishing :
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    Keywords: Medicine Research. ; Biology Research. ; Biochemistry. ; Internal medicine. ; Lipids. ; Bioinformatics. ; Medical genetics. ; Biomedical Research. ; Chemical Biology. ; Internal Medicine. ; Lipidology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Sterols from the post-lanosterol part of cholesterol synthesis – novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.
    Abstract: This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.
    Type of Medium: Online Resource
    Pages: V, 171 p. 57 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030396848
    URL: https://doi.org/10.1007/978-3-030-39684-8
    DOI: 10.1007/978-3-030-39684-8
    DDC: 610.72
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    Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1 : Neuroimmunology and Neurogenetics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Biomedical Research. ; Biomedical Research. ; Biomedical Research. ; Medical Genetics.
    Description / Table of Contents: Chaptre 1. Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction -- Chaptre 2. Epidemiology of Brain and Spinal Cord Tumors -- Chaptre 3. The Role of Neuro-inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 4. The Role of Cellular Immunity and Adaptive Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 5. Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors -- Chaptre 6. Cell of Origin of Brain and Spinal Cord Tumors -- Chaptre 7. The Role of Bioinformatics and Imaging Models in Tumorigenesis and Treatment Response of Brain and Spinal Cord Neoplasms -- Chaptre 8. The Role of Epigenetics in Brain and Spinal Cord Tumors -- Chaptre 9. Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors -- Chaptre 10. Nutrition and Diet: A Double-Edged Sword in Development and Treatment of Brain Tumors -- Chaptre 11. The Role of Nanotechnology in Brain Tumors -- Chaptre 12. The Role of Nanotechnology in Spinal Cord Tumors -- Chaptre 13. The Economic Burden of Malignant Brain Tumors.
    Abstract: Brain tumors comprise about 5–9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.
    Type of Medium: Online Resource
    Pages: XX, 231 p. 30 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031147326
    Series Statement: Advances in Experimental Medicine and Biology, 1394
    URL: https://doi.org/10.1007/978-3-031-14732-6
    DOI: 10.1007/978-3-031-14732-6
    DDC: 610.72
    Language: English
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    The Hereditary Basis of Childhood Cancer (2021)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Medical Genetics. ; Medical Genetics. ; Biomedical Research. ; Pharmacology.
    Description / Table of Contents: 1: Li-Fraumeni Syndrome -- 2: Pediatric Central Nervous System Cancer Predisposition -- 3: Rhabdoid Tumors -- 4: Neurofibromatosis -- 5: Pheochromocytoma and Paraganglioma syndromes -- 6: Wilms tumor -- 7: Hereditary Overgrowth Syndromes -- 8: Multiple Endocrine Neoplasias and Associated Non-Endocrine Conditions -- 9: DICER1 Syndrome -- 10: Cancer-prone Inherited Bone Marrow Failure, Myelodysplastic and Acute Myeloid Leukemia Syndromes -- 11: Inherited Risk for Childhood Leukemia -- 12: Inherited pediatric cancer in low and intermediate resource countries -- 13: Frontline Ethico-legal Issues in Childhood Cancer Genetics Research -- 14: Genetic counseling and testing -- 15: Psychosocial aspects of childhood cancer genetics -- 16: Recognition of cancer predisposition syndromes.
    Abstract: This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the ‘disease-related’ chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where ‘modern’ technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.
    Type of Medium: Online Resource
    Pages: XI, 491 p. 52 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030744489
    URL: https://doi.org/10.1007/978-3-030-74448-9
    DOI: 10.1007/978-3-030-74448-9
    DDC: 616.042
    Language: English
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    Concepts and Applications of Stem Cell Biology : A Guide for Students (2020)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Stem cells. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Medical Genetics. ; Stem Cell Biology. ; Biomedical Research. ; Biotechnology.
    Description / Table of Contents: Chapter 1: Introduction: a decade teaching stem cell biology -- Chapter 2: Preimplantation development: from germ cells to blastocyst -- Chapter 3: Origins of pluripotency: from stem cells to germ cells -- Chapter 4: Human induced pluripotent stem (hiPS) cells: generation and applications -- Chapter 5: Cellular reprogramming and aging -- Chapter 6: Cloning -- Chapter 7: Stem cells in plant development -- Chapter 8: Axial stem cells and the formation of the vertebrate body -- Chapter 9: Skeletal muscle development - from stem cells to body movement -- Chapter 10: Cardiac regeneration and repair: from mechanisms to therapeutic strategies -- Chapter 11: Reproducing human brain development in vitro: generating cerebellar neurons for modelling cerebellar ataxias -- Chapter 12: Neurotoxicology and disease modelling -- Chapter 13: Mesenchymal stem cells for cutaneous wound healing.
    Abstract: This textbook will support graduate students with learning materials rich in the basic concepts of stem cell biology, in its most widespread and updated perspective. The chapters are conceived in a way for students to understand the meaning of pluripotency, the definition of embryonic stem cells and the formation of multicellular structures such as organoids together with the underlying principles of their epigenetic. This textbook also discusses adult stem cells and the potential use of these cells, in particular neural, mesenchymal, and several types of muscular cells, in biomedical research and clinical applications. This textbook represents a vital complement to the text on Essential Current Concepts of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.
    Type of Medium: Online Resource
    Pages: XXII, 267 p. 85 illus., 79 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030439392
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-43939-2
    DOI: 10.1007/978-3-030-43939-2
    DDC: 616.042
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    Introduction to Epigenetics (2021)
    Cham :Springer International Publishing :
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    Keywords: Genetics. ; Medicine Research. ; Biology Research. ; Cytology. ; Medical genetics. ; Genetics and Genomics. ; Biomedical Research. ; Cell Biology. ; Medical Genetics.
    Description / Table of Contents: Biology of Chromatin -- Chromatin Dynamics -- Cellular Memory -- Dosage Compensation Systems -- Genomic Imprinting -- RNA-based Mechanisms of Gene Silencing -- Regeneration and Reprogramming -- Epigenetics and Cancer -- Epigenetics and Metabolism.
    Abstract: This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease.
    Type of Medium: Online Resource
    Pages: XII, 215 p. 81 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030686703
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-68670-3
    DOI: 10.1007/978-3-030-68670-3
    DDC: 576.5
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    Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Molecular genetics. ; Cardiovascular system. ; Physiology. ; Cancer Genetic aspects. ; Biochemical markers. ; Medical Genetics. ; Molecular Genetics. ; Cardiovascular Physiology. ; Cancer Genetics and Genomics. ; Biomarkers.
    Description / Table of Contents: Biogenesis and Modes of Action Of miRs And Circular And Long Non-coding RNAs -- Obesity, Insulin Resistance in Adipose Tissue And Thermogenesis -- Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease -- Atherosclerosis -- Cardiomyopathy and Heart Failure -- Cancer -- Communication between Tumor-Adjacent Tissues and Tumors with Emphasis on Role of Inflammatory Cells -- General Conclusions and Future Perspectives.
    Abstract: This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine. .
    Type of Medium: Online Resource
    Pages: XXX, 265 p. 26 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030688448
    URL: https://doi.org/10.1007/978-3-030-68844-8
    DOI: 10.1007/978-3-030-68844-8
    DDC: 616.042
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    Sex-Based Differences in Lung Physiology (2021)
    Cham :Springer International Publishing :
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    Keywords: Human physiology. ; Respiratory organs Diseases. ; Cytology. ; Medical genetics. ; Cancer. ; Human Physiology. ; Pneumology. ; Cell Biology. ; Medical Genetics. ; Cancer Biology.
    Description / Table of Contents: Sex Differences in Respiratory Physiology -- Sex Differences in the Anatomy of the Airways and the Lungs: Impact on Dysanapsis across the Lifespan -- Sex Steroids and Their Influence in Lung Diseases Across the Lifespan -- Sex Differences in the Developing Lung: Implications for Disease -- Neonatal Lung Disease: Mechanisms Driving Sex Differences -- Sex Differences in Cystic Fibrosis Across the Lifespan -- Sex Differences in Chronic Obstructive Pulmonary Disease -- Sex-Differences in Pulmonary Arterial Hypertension -- Sex and Gender Differences in the Susceptibility to Environmental Exposures -- Respiratory Sex Differences in Response to Smoke Exposure -- Sex Differences in Adaptive Immunity in Chronic Lung Disease -- Network Medicine and Systems Biology Considerations to Understand Sex Differences in Lung Disease -- Sex Differences in Respiratory Infection -- Androgen Excess in Women and the Respiratory System -- Sex Differences in Circadian Biology: Influences on Lung Health and Disease -- Sex Differences in the Coronavirus Disease 2019.
    Abstract: This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung’s innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease. To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.
    Type of Medium: Online Resource
    Pages: XX, 490 p. 38 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030635497
    Series Statement: Physiology in Health and Disease,
    URL: https://doi.org/10.1007/978-3-030-63549-7
    DOI: 10.1007/978-3-030-63549-7
    DDC: 612
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    Behavioral Neurobiology of Suicide and Self Harm (2020)
    Cham :Springer International Publishing :
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    Keywords: Neurochemistry. ; Bioinformatics. ; Medical genetics. ; Medical informatics. ; Public health. ; Psychiatry. ; Neurochemistry. ; Bioinformatics. ; Medical Genetics. ; Health Informatics. ; Public Health. ; Psychiatry.
    Description / Table of Contents: Why Are Suicide Rates Increasing in the United States? Towards a Multilevel Reimagination of Suicide Prevention?- Barriers for the Research, Prevention, and Treatment of Suicidal Behavior -- The Role of Epigenetic Dysregulation in Suicidal Behaviors -- Suicide: Genetics and Heritability -- Toward a Biosignature of Suicide Reattempt -- Sex, Gender, and Suicidal Behavior -- Neurocognition and the Suicidal Process -- Lipids and Suicide Risk -- Glutamine and New Pharmacological Targets to Treat Suicidal Ideation -- The Role of Opiates in Social Pain and Suicidal Behavior -- Sleep Disturbances and Suicidal Behavior -- Ecological Momentary Assessment for Monitoring Risk of Suicide Behavior.
    Abstract: This book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide. Suicidal behavior, perhaps, is the most complex behavior that combines biological, social, and psychological factors. A new frontier and new opportunities are opening with the technologies of data acquisition and data analysis. Personalized models based on digital phenotype could provide promising strategies for preventing suicide.
    Type of Medium: Online Resource
    Pages: X, 245 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030575748
    Series Statement: Current Topics in Behavioral Neurosciences, 46
    URL: https://doi.org/10.1007/978-3-030-57574-8
    DOI: 10.1007/978-3-030-57574-8
    DDC: 612.8042
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    Age-related Macular Degeneration : From Clinic to Genes and Back to Patient Management (2021)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Ophthalmology. ; Human physiology. ; Medical Genetics. ; Ophthalmology. ; Human Physiology.
    Description / Table of Contents: 1. Age-Related Macular Degeneration: Epidemiology and Clinical Aspects -- 2. Ocular Imaging for Enhancing the Understanding, Assessment, and Management of Age-Related Macular Degeneration -- 3. Histopathology of Age-Related Macular Degeneration and Implications for Pathogenesis and Therapy -- 4. Bruch’s Membrane and the Choroid in Age-Related Macular Degeneration -- 5. Innate Immunity in Age-Related Macular Degeneration -- 6. Immunological Aspects of Age-Related Macular Degeneration -- 7. AMD Genetics: Methods and Analyses for Association, Progression, and Prediction -- 8. Making Biological Sense of Genetic Studies of Age-Related Macular Degeneration -- Age-Related Macular Degeneration: From Epigenetics to Therapeutic Implications -- 10. Mitochondria: The Retina’s Achilles’ Heel in AMD -- 11. Cell-Based Therapies for Age-Related Macular Degeneration -- 12. Current Management of Age-Related Macular Degeneration.
    Abstract: This edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches. AMD is a leading cause of largely incurable blindness worldwide and projected to double from 2.07 million to 5.44 million individuals by 2050 in the United States. Globally, 288 million individuals are projected to have AMD by 2040. The disease has enormous socioeconomic impact on the affected individuals, their families and the society. This book will bring together the state of the art basic science knowledge with clinically relevant findings and address the challenges for future research in AMD. The intersection of different disciplines will provide potential areas for further investigations to reduce the burden of blindness from AMD. This book offers an appealing and insightful resource for clinicians, scientists, students and fellows.
    Type of Medium: Online Resource
    Pages: X, 314 p. 73 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030660147
    Series Statement: Advances in Experimental Medicine and Biology, 1256
    URL: https://doi.org/10.1007/978-3-030-66014-7
    DOI: 10.1007/978-3-030-66014-7
    DDC: 616.042
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    GeNeDis 2018 : Genetics and Neurodegeneration (2020)
    Cham :Springer International Publishing :
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    Keywords: Neurosciences. ; Medical genetics. ; Neuroscience. ; Medical Genetics.
    Description / Table of Contents: In Silico and In Vivo Studies on Quercetin as Potential Anti- Parkinson Agent -- Exhaled Breath Condensate (EBC). Is it a viable source of biomarkers for lung diseases? -- Treatment development for Alzheimer's disease: how are we doing? -- Microbiome hijacking towards an integrative pest management pipeline -- Regulation and roles of autophagy in the brain -- Three-dimensional models for studying neurodegenerative and neurodevelopmental diseases -- Assessment of factors contributing to the enhancement of memory and cognitive abilities in the context of neurosciences -- Buccal Mucosa Biomarkers in Alzheimer’s Disease -- Engaging social interest and creating awareness for the behavioural and psychological symptoms of dementia -- Structural study of the DNA – Clock/Bmal1 complex provides insights for the role of cortisol, hGR and HPA axis in stress management and sleep disorders -- The Effects of Quantum Entanglement on Chromatin and Gene Expression -- Olive Oil Polyphenols in Neurodegenerative Pathologies -- Human pluripotent stem cells as in vitro models of neurodegenerative diseases -- Nutritional Lipidomics in Alzheimer's Disease -- Alzeheimer’s Disease Therapeutic Approaches -- Stress and Wellbeing of Psychiatry Trainees: A Literature Review -- Brief Cognitive Tests in the case of Dementia and Alzheimer’s Disease Early Diagnosis -- Synthesis, Molecular Docking studies and Biological Evaluation of N-Acylarylhydrazones as Anti-inflammatory agents -- Exosome biomarkers revolutionize preclinical diagnosis of neurodegenerative diseases and assessment of treatment responses in clinical trials -- Biomarkers as a different approach in prevention and treatment of drug addiction (preliminary study) -- Sleep disorders and Restless Leg Syndrome in hemodialysis patients in Greece: a cross-sectional study -- Craniofacial and neurological phenotype in a patient with de novo 18q microdeletion and 18p microduplication -- What do recent clinical trials teach us about the etiology of AD -- Developmental Biology and Transgenic Avian Embryology: Body Alterity Bioart Wet Lab -- Gene editing, sexual reproduction and the arts: the present, the future and the imagined -- Amyotrophic Lateral Sclerosis: Current status in diagnostic biomarkers -- Synthesis and Characterization of Biologically Significant, 5-[N,N-dialkylamino alkoxy] azaindole 2-one,3- thiosemicarbazones and 5-[N,N-dialkylamino alkoxy] azaindole 3-hydrazone, 2-ones -- Genetic counseling for adult-onset spinal and bulbar muscular atrophy (Kennedy syndrome). Multiple cases of prenatal testing in a family -- Transcriptomics and Metabolomics in Amyotrophic Lateral Sclerosis -- Ocimum Sanctum Linn: A Potential Adjunct Therapy for Hyperhomocysteinemia – Induced Vascular Dementia -- Alzheimer's disease: The role of mutations in protein folding.
    Abstract: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people. .
    Type of Medium: Online Resource
    Pages: XII, 262 p. 42 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030326333
    Series Statement: Advances in Experimental Medicine and Biology, 1195
    URL: https://doi.org/10.1007/978-3-030-32633-3
    DOI: 10.1007/978-3-030-32633-3
    DDC: 612.8
    Language: English
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    Diagnostic Genetic Testing : Core Concepts and the Wider Context for Human DNA Analysis (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Diagnosis. ; Bioethics. ; Medical Genetics. ; Diagnosis. ; Bioethics.
    Description / Table of Contents: Genetic Testing, Some Themes and Some Basics -- Autosomal Dominant Inheriance and Huntington Disease -- Autosomal Recessive Inheritance and Cystic Fibrosis -- X-linked Inheritance: a Question of Gender -- Genetics Testing in Cancer -- DNA Testing, Genes and Identity -- Out of Sequence: Genome-Scale Testing -- DNA Testing: Pulling the Strands Together.
    Abstract: Over the last decade, technical advances have allowed genomic testing which provides a great opportunity for diagnosis but also an increased chance of uncertain or unexpected findings. This book addresses many of the questions that arise in this context and summarizes the essential concepts in diagnostic genetic testing in an easy-to-read manner. It also covers some broad context for the practical and ethical implications of examining human DNA sequences. The book starts with a general introduction to the field, providing enough background to allow readers without any previous education in genetics to comprehend the material in the subsequent chapters. The main part explores differing aspects of human genetics and the wider implications of testing in these areas. The author covers not only single gene inheritance, but also genetic testing of cancers and how testing benefits the patients. Special emphasis is also given to the questions of genetics and identity. The concluding part then draws the main themes together and summarises the wider significance of genetics. It also explores the gap between promises made for the impact of advances in genetics, and the actual benefits to patients. The book is written for everyone interested to learn about the process of genetic testing and the broader implications. Moreover, it is aimed at health professionals with an interest in genetics, at students or scientific trainees looking for an introduction to diagnostic genetics, and at professionals in health policy or health journalism.
    Type of Medium: Online Resource
    Pages: XXII, 131 p. 17 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030855109
    URL: https://doi.org/10.1007/978-3-030-85510-9
    DOI: 10.1007/978-3-030-85510-9
    DDC: 616.042
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    GeNeDis 2020 : Genetics and Neurodegenerative Diseases (2021)
    Cham :Springer International Publishing :
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    Keywords: Neurosciences. ; Medical genetics. ; Bioinformatics. ; Neuroscience. ; Medical Genetics. ; Bioinformatics. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Attitudes and smoking prevalence among undergraduate students in central Greece -- 2-Care of patients with Alzheimer’s disease -- 3-Regulation of antioxidant enzymes levels in rat brain -- 4-NIRS-based assessment of cerebral oxygenation during high definition anodal transcranial direct current stimulation in patients with posttraumatic encephalopathy -- 5-Cerebral critical closing pressure at concomitant traumatic brain injury -- 6-The role of inflammatory biomarkers as a diagnostic tool for possible late-life cognitive decline and dementias -- 7-The Development of Antisense RNA Treatments using Engineered Protein Substrates -- 8-Biomarker-driven analysis using high-throughput approaches in neuroinflammation and neurodegenerative diseases -- 9-Sensitive and Stereo specific high-performance liquid chromatographic method for flurbiprofen in human plasma -- 10-Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study -- 11-Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological Voices in Parkinsonian Patients -- 12-Effects of an 8-Week Stress Management Program in Women with Breast Cancer: A Randomized Controlled Trial -- 13-The Rosenberg Self-Esteem Scale: Translation and Validation in the Greek Language in Adolescents -- 14-Stress system activation analysis in Greek female adolescents: a bioimpedance study -- 15-Kisspeptin and the genetic obesity interactome -- 16-The importance of diagnostic and prognostic biomarkers identification and classification towards understanding ALS pathogenesis -- 17-Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia -- 18-Ebola virus disease and current therapeutic strategies; A review -- 19-Hyperbaric Oxygen Therapy effect on “Kinesia Paradoxa” Brain Circuits -- 20-Early and Very Early GRIM19 and MCL1 Expression are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line -- 21-Phospholipid Fatty Acid Profile of Spirulina platensis -- 22-Chronic systemic inflammation measured by bioimpedance technology before and after sleeve gastrectomy: a feasibility study -- 23-Synthesis and Biological Evaluation Substituted Thiophene Derivatives -- 24-Force spectroscopy in mechanical protein domains unfolding -- 25-Investigating the genetic component of Parkinson’s Disease -- 26-Urticaria from the Neurodermatological Perspective: A Temporal Analysis of Urticaria and Cognition -- 27-Novel Low-Noise CMOS Bioamplifier for the Characterization of Neurodegenerative Diseases -- 28-The Kentucky Inventory of Mindfulness Skills in Greek Undergraduate and Postgraduate Students -- 29-Synthesis, in silico stuiesand biological evaluation of 1, 3 ,4 oxadiazino indole derivatives -- 30-Designing and screening of new schiff bases of indole derivatives for anti-bacterial activity by in-silico methods and docking studies -- 31-Use of vitamin D bolus in fortified juice for improving vitamin D status in children with Cerebral Palsy -- 32-Microbes and the games they play -- 33-Impurity Profiling and Identification of 2,6 diisopropylphenol by Raman spectroscopy -- 34-Cultural Accommodation of the Strengthening Families Program for Parents and Young Adolescents 10-14: Greek Phase I & II Study -- 35-The effect of nutrients on Alzheimer’s disease biomarkers: A metabolomic approach -- 36-The impact of exercising in the quality of life of people with Aementia-Alzheimer disease -- 37-Advanced Health Technologies and Nanotechnologies in Neurodegenerative Diseases -- 38-Phenotype and genotype study in a case of frontometaphyseal dysplasia 1 -- 39-Craniofacial and neurological phenotype in a case of oculodentodigital syndrome -- 40-Clinical and molecular study of common thrombophilia mutation prothrombin G20210A -- 41-Prenatal genetic testing for X-linked hypohidrotic ectodermal dysplasia -- 42-Preimplantation genetic testing for spastic paraplegia type 3 -- 43-Synthesis, anti-inflammatory activity and in-silico studies of some new 3-({P-DIMETHYLAMINO}BENZYLIDENE YDRAZINYLIDENE)-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES -- 44-Design, characterization and docking studies of some novel isatin derivatives for anticonvulsant and antidepressant activity -- 45-Skin mirrors Brain: A Chance for Alzheimer’s Disease Research -- 46-Mitochondrial homeostasis in neurodegeneration and ageing -- 47-The Alzheimer's Disease Chronicles: will evidence triumph over adversity? -- 48-Liposomes: Production Methods and Application in Alzheimer’s Disease -- 49-Developing Treatments for Alzheimer’s and Related Disorders with Precision Medicine: A Vision -- 50-Biomarkers and Precision Medicine in Alzheimer’s Disease -- 51-The role of microRNAs in thrombosis -- 52-Photo-oxygenation: an innovative new therapeutic approach against amyloidoses.
    Abstract: The 4th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The relation between genetics and its effect on several diseases are thoroughly examined in this volume. This volume focuses on the sessions from the conference on Genetics and Neurodegenerative Diseases.
    Type of Medium: Online Resource
    Pages: XV, 435 p. 133 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030787875
    Series Statement: Advances in Experimental Medicine and Biology, 1339
    URL: https://doi.org/10.1007/978-3-030-78787-5
    DOI: 10.1007/978-3-030-78787-5
    DDC: 612.8
    Language: English
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    The Mesentery and Inflammation (2023)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Neurosciences. ; Psychiatry. ; Medical genetics. ; Clinical health psychology. ; Human physiology. ; Pharmacology. ; Neuroscience. ; Psychiatry. ; Medical Genetics. ; Health Psychology. ; Human Physiology.
    Description / Table of Contents: Introduction -- Development, anatomy and histology of the mesentery -- The mesenteric intersitium -- Mesnteric organ lymphatics -- The mesentery as an immunological organ -- Bacterial translocation to the mesentery -- The microbiome of mesenteric lymh nodes -- Mesenteric Adenopathy and adenitis -- The effects of mesenteric inflammation on the intestine -- The mesentery as an ADME organ -- Targteing the mesentery using surgery -- Future directions.
    Abstract: The volume summarizes the most recent advances in our understanding of the mesentery and explains the how these are important in inflammation. It comprises a series of state of the art chapters by leading authorities in each area. It explains how recent advances in our understanding of the mesenteric organ, have advanced the diagnosis and treatment abdominal and systemic conditions including cancer, inflammatory bowel disease and endocrine conditions such as diabetes, and circulatory disorders such as atherosclerosis. .
    Type of Medium: Online Resource
    Pages: X, 226 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031177743
    Series Statement: Progress in Inflammation Research, 90
    URL: https://doi.org/10.1007/978-3-031-17774-3
    DOI: 10.1007/978-3-031-17774-3
    DDC: 615
    Language: English
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  • 45
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    GeNeDis 2022 : Neuroscientific Advances (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Medical genetics. ; Bioinformatics. ; Neuroscience. ; Medical Genetics. ; Bioinformatics. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Attitudes and smoking prevalence among undergraduate students in central Greece -- 2-Care of patients with Alzheimer’s disease -- 3-Regulation of antioxidant enzymes levels in rat brain -- 4-NIRS-based assessment of cerebral oxygenation during high definition anodal transcranial direct current stimulation in patients with posttraumatic encephalopathy -- 5-Cerebral critical closing pressure at concomitant traumatic brain injury -- 6-The role of inflammatory biomarkers as a diagnostic tool for possible late-life cognitive decline and dementias -- 7-The Development of Antisense RNA Treatments using Engineered Protein Substrates -- 8-Biomarker-driven analysis using high-throughput approaches in neuroinflammation and neurodegenerative diseases -- 9-Sensitive and Stereo specific high-performance liquid chromatographic method for flurbiprofen in human plasma -- 10-Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study -- 11-Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological Voices in Parkinsonian Patients -- 12-Effects of an 8-Week Stress Management Program in Women with Breast Cancer: A Randomized Controlled Trial -- 13-The Rosenberg Self-Esteem Scale: Translation and Validation in the Greek Language in Adolescents -- 14-Stress system activation analysis in Greek female adolescents: a bioimpedance study -- 15-Kisspeptin and the genetic obesity interactome -- 16-The importance of diagnostic and prognostic biomarkers identification and classification towards understanding ALS pathogenesis -- 17-Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia -- 18-Ebola virus disease and current therapeutic strategies; A review -- 19-Hyperbaric Oxygen Therapy effect on “Kinesia Paradoxa” Brain Circuits -- 20-Early and Very Early GRIM19 and MCL1 Expression are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line -- 21-Phospholipid Fatty Acid Profile of Spirulina platensis -- 22-Chronic systemic inflammation measured by bioimpedance technology before and after sleeve gastrectomy: a feasibility study -- 23-Synthesis and Biological Evaluation Substituted Thiophene Derivatives -- 24-Force spectroscopy in mechanical protein domains unfolding -- 25-Investigating the genetic component of Parkinson’s Disease -- 26-Urticaria from the Neurodermatological Perspective: A Temporal Analysis of Urticaria and Cognition -- 27-Novel Low-Noise CMOS Bioamplifier for the Characterization of Neurodegenerative Diseases -- 28-The Kentucky Inventory of Mindfulness Skills in Greek Undergraduate and Postgraduate Students -- 29-Synthesis, in silico stuiesand biological evaluation of 1, 3 ,4 oxadiazino indole derivatives -- 30-Designing and screening of new schiff bases of indole derivatives for anti-bacterial activity by in-silico methods and docking studies -- 31-Use of vitamin D bolus in fortified juice for improving vitamin D status in children with Cerebral Palsy -- 32-Microbes and the games they play -- 33-Impurity Profiling and Identification of 2,6 diisopropylphenol by Raman spectroscopy -- 34-Cultural Accommodation of the Strengthening Families Program for Parents and Young Adolescents 10-14: Greek Phase I & II Study -- 35-The effect of nutrients on Alzheimer’s disease biomarkers: A metabolomic approach -- 36-The impact of exercising in the quality of life of people with Aementia-Alzheimer disease -- 37-Advanced Health Technologies and Nanotechnologies in Neurodegenerative Diseases -- 38-Phenotype and genotype study in a case of frontometaphyseal dysplasia 1 -- 39-Craniofacial and neurological phenotype in a case of oculodentodigital syndrome -- 40-Clinical and molecular study of common thrombophilia mutation prothrombin G20210A -- 41-Prenatal genetic testing for X-linked hypohidrotic ectodermal dysplasia -- 42-Preimplantation genetic testing for spastic paraplegia type 3 -- 43-Synthesis, anti-inflammatory activity and in-silico studies of some new 3-({P-DIMETHYLAMINO}BENZYLIDENE YDRAZINYLIDENE)-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES -- 44-Design, characterization and docking studies of some novel isatin derivatives for anticonvulsant and antidepressant activity -- 45-Skin mirrors Brain: A Chance for Alzheimer’s Disease Research -- 46-Mitochondrial homeostasis in neurodegeneration and ageing -- 47-The Alzheimer's Disease Chronicles: will evidence triumph over adversity? -- 48-Liposomes: Production Methods and Application in Alzheimer’s Disease -- 49-Developing Treatments for Alzheimer’s and Related Disorders with Precision Medicine: A Vision -- 50-Biomarkers and Precision Medicine in Alzheimer’s Disease -- 51-The role of microRNAs in thrombosis -- 52-Photo-oxygenation: an innovative new therapeutic approach against amyloidoses.
    Abstract: The 5th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Neuroscientific Advances.
    Type of Medium: Online Resource
    Pages: XXXI, 673 p. 58 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031319860
    Series Statement: Advances in Experimental Medicine and Biology, 1425
    URL: https://doi.org/10.1007/978-3-031-31986-0
    DOI: 10.1007/978-3-031-31986-0
    DDC: 612.8
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    Genome Editing in Biomedical Sciences (2023)
    Cham :Springer International Publishing :
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    Keywords: Genetics. ; Genomics. ; Cancer Genetic aspects. ; Epigenetics. ; Medical genetics. ; Genetics and Genomics. ; Genomics. ; Cancer Genetics and Genomics. ; Epigenetics. ; Medical Genetics.
    Description / Table of Contents: What is the CRISPR system and how it is used? -- Modern approaches to mouse genome editing using the CRISPR-Cas toolbox and their applications in functional genomics and translational research -- Long Non-Coding RNAs and Crispr-Cas edition in Tumorigenesis -- The Crispr/Cas system in human cancer -- Using CRISPR/Cas9 to Edit a Thyroid Cancer Cell Line -- Genome editing for engineering the next generation of advanced immune cell therapies -- CRISPR Genome Editing and the Study of Chagas Disease -- Genome Editing Tools for Lysosomal Storage Disorders -- CRISPR Libraries and Whole-Genome Screening to Identify Factors for Viral Infections -- Gene Editing Technologies Targeting TFAM and its Relation to Mitochondrial Diseases -- The Gene-Edited Babies Controversy: Reactions in the Scientific Community, Social Media, and the Press -- Index.
    Abstract: This volume focuses on applying the Crispr system in editing the genome of human cells (in vitro and in vivo) and model organisms used in biomedical research. With the advent of Crispr technology, genome editing soon became a procedure of great interest to laboratories worldwide due to its relative ease and accuracy. In biomedical sciences, genome editing by Crispr has already enabled the development of new experimental model systems. In medicine, therapeutic alternatives for the genetic "correction" of diseases have already begun to appear. Therefore, the book's purpose is to bring in a single volume, chapters that show the scientific community in biomedicine, medicine, human genetics, oncology, virology, and parasitology, among others, the advances in genomic editing. In a chapter dedicated to the ethical aspects of human genomic editing, we also address what we can and should do with this (bio)technology. The book chapters were written by productive researchers specializing in Crispr genome editing. The chapters cover the concept of Crispr and genome editing and how to use this new methodology in biomedical research and medicine, among other aspects, including the ethical controversy around its use in humans. The writing of the chapters keeps a specialized language intelligible enough for those who want to introduce themselves to the subject.
    Type of Medium: Online Resource
    Pages: XI, 209 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031333255
    Series Statement: Advances in Experimental Medicine and Biology, 1429
    URL: https://doi.org/10.1007/978-3-031-33325-5
    DOI: 10.1007/978-3-031-33325-5
    DDC: 576.5
    Language: English
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    Fundamentals of RNA Structure and Function (2022)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Biomaterials. ; Nucleic acids. ; Biotechnology. ; Medical Genetics. ; Nucleic Acid. ; Biotechnology.
    Description / Table of Contents: 1. RNA-Composition and Base Pairing -- 2. Architecture of RNA -- 3. Small Catalytic RNA -- 4. The Spliceosome: A Large Catalytic RNA -- 5. A Genomic Perspective on RNA -- 6. The mRNA and the New Vaccines -- 7. Riboswitches: Sensors and Regulators -- 8. Small Non-Coding RNA, miRNA in Gene Regulation -- 9. CRISPR-Cas Systems, The science and ethics of gene manipulation -- 10. Transcription.
    Abstract: This highly illustrated textbook provides an essential overview on RNA architecture and function, it offers insights into the RNA basics and also explains novel RNA technologies, such as CRISPR-Cas and their applications. In addition, the mRNA based vaccine technology, which has long been tested, also before the COVID-19 pandemic, is discussed and students receive a basic understanding of this important medical application. The textbook is written by Prof. Grover in collaboration with her students and has an easily accessible style. The book provides a great tool for young researchers and students in biology, biomedical engineering or biochemistry, looking for a compact introduction or refresher work on RNA, including the newest findings and technologies. It is an ideal starter to learn about several RNA specific topics and to research them further.
    Type of Medium: Online Resource
    Pages: XVI, 246 p. 108 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030902148
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-90214-8
    DOI: 10.1007/978-3-030-90214-8
    DDC: 616.042
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    The Chemical Biology of Long Noncoding RNAs (2020)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Biomaterials. ; Nucleic acids. ; Biotechnology. ; Medical Genetics. ; Nucleic Acid. ; Biotechnology.
    Description / Table of Contents: Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells’ Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases.-Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and β-cell Regulation.
    Abstract: This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.
    Type of Medium: Online Resource
    Pages: X, 545 p. 49 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030447434
    Series Statement: RNA Technologies, 11
    URL: https://doi.org/10.1007/978-3-030-44743-4
    DOI: 10.1007/978-3-030-44743-4
    DDC: 616.042
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    Obesity in the 21st Century (2023)
    Cham :Springer International Publishing :
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    Keywords: Nutrition   . ; Human physiology. ; Metabolism Disorders. ; Medicine, Preventive. ; Health promotion. ; Medical genetics. ; Nutrition. ; Human Physiology. ; Metabolic Disease. ; Health Promotion and Disease Prevention. ; Medical Genetics.
    Description / Table of Contents: Chapter 1. Body Composition: What Are We Made of? -- Chapter 2. Variation in Body Size and Obesity -- Chapter 3. Genetics and Obesity -- Chapter 4. Non-dietary Factors and Weight Gain -- Chapter 5. Diet and Obesity -- Chapter 6. Obesity and Disease -- Chapter 7. Dieting, Physical Activity and Weight Loss -- Chapter 8. Drugs and Weight Loss -- Chapter 9. Surgery and Weight Loss -- Chapter 10. Alternative Weight Loss Methods.
    Abstract: In recent years, the focus of obesity prevention has been on diet. However, diet is only one of many factors which play a role in the development of obesity. This book looks at these factors and the latest research on how they contribute to the development of obesity, and the many different methods that have been and are being used to treat and prevent obesity. Written in an accessible language, this book provides the latest and most up to date information on research into the causes, health consequences and treatment of obesity. It educates and advocates for healthier lifestyles, a better understanding of diets and weight loss programs, and associated chronic diseases. It is written for everyone interested in obesity and enables the reader to take informed action to reduce the likelihood of putting on weight and the risk of developing chronic illnesses.
    Type of Medium: Online Resource
    Pages: XIII, 121 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031391682
    URL: https://doi.org/10.1007/978-3-031-39168-2
    DOI: 10.1007/978-3-031-39168-2
    DDC: 613.2
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    Tumor Microenvironment : The Main Driver of Metabolic Adaptation (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Immunology. ; Human physiology. ; Cytology. ; Cancer Biology. ; Biomedical Research. ; Medical Genetics. ; Immunology. ; Human Physiology. ; Cell Biology.
    Description / Table of Contents: Preface -- Tumor microenvironment a job of several holders -- Tumor microenvironment- a selective pressure boosting cancer -- Lactate and lactate transporters as key players in the maintenance of the Warburg effect -- Section 1. Adaptive metabolic features are sustained by tumor microenvironment -- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis -- Gut microbiota and cancer of the host: colliding interests -- Metabolic plasticity of tumor cells: how they do adapt to food deprivation -- Multifaceted oncogenic role of adipocytes in the tumour microenvironment -- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology -- Monocytes and macrophages in cancer: unsuspected roles -- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression -- Microenvironment driven metabolic adaptation in melanoma -- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis -- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt -- The bone marrow niche - the tumor microenvironment that ensures leukemia progression -- Section 3. Metabolic fitness and therapy response in cancer -- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer -- The metabolic remodelling in lung cancer and its putative consequence in therapy response -- Hydrogen sulfide metabolism and signaling in the tumor microenvironment -- Using metabolic adaptation to design new drugs -- Metabolomics- a new way of screening cancer -- NMR as a tool for metabolomics -- Section 5. Animal models- addressing cancer microenvironment -- Animal models to study cancer and its microenvironment -- Modulating the metabolic phenotype of cancer microenvironment -- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae -- Section 6. In vitro and ex vivo cancer models -- In vitro and ex vivo models- the tumor microenvironment in a flask -- Index.
    Abstract: This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.
    Type of Medium: Online Resource
    Pages: VII, 443 p. 63 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030340254
    Series Statement: Advances in Experimental Medicine and Biology, 1219
    URL: https://doi.org/10.1007/978-3-030-34025-4
    DOI: 10.1007/978-3-030-34025-4
    DDC: 571.978
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    HSF1 and Molecular Chaperones in Biology and Cancer (2020)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Cancer. ; Medicine Research. ; Biology Research. ; Proteins . ; Proteins. ; Medical Genetics. ; Cancer Biology. ; Biomedical Research. ; Protein Biochemistry. ; Proteins.
    Description / Table of Contents: Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks – redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.
    Abstract: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 182 p. 31 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030402044
    Series Statement: Advances in Experimental Medicine and Biology, 1243
    URL: https://doi.org/10.1007/978-3-030-40204-4
    DOI: 10.1007/978-3-030-40204-4
    DDC: 616.042
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    Mechanisms of Genome Protection and Repair (2020)
    Cham :Springer International Publishing :
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    Keywords: Medical genetics. ; Cytology. ; Biochemistry. ; Medicine Research. ; Biology Research. ; Cancer. ; Medical Genetics. ; Cell Biology. ; Biochemistry. ; Biomedical Research. ; Cancer Biology.
    Description / Table of Contents: Preface -- Kinetic Milestones of Damage Recognition by DNA Glycosylases of the Helix–Hairpin–Helix Structural Superfamily -- Protein Engineering of DNA-Dependent Enzymes -- A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis -- Impact of PARP1, PARP2 and PARP3 on the Base Excision Repair of Nucleosomal DNA -- Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling -- DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance -- Mystery of Expansion: DNA Metabolism and Unstable Repeats -- The Detection of 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine in Circulating Cell-Free DNA: A Step Towards Longitudinal Monitoring of Health -- Biotransformation and Toxicities of Aristolochic Acids -- Mechanisms of Sugar Beet Response to Biotic and Abiotic Stresses -- Studying ALS: Current Approaches, Effect on Potential Treatment Strategy.
    Abstract: This volume is about DNA damage and repair. It covers recent advances in several important research areas of this rapidly expanding field, and does so at several levels, from individual molecules to organisms. The topics include mechanisms of damage recognition by DNA repair enzymes, chromatin response to DNA damage, special ways of mutagenesis, biomarkers of genotoxicity, and the integrated organism response to genotoxic and other kinds of stress. The book starts with two chapters about structural and mechanistic features of protein–DNA interactions that ensure fast and reliable discrimination between targets – be it DNA modifications or specific sequences – and non-targets. Examples of particular proteins and their function in repair regulation, translesion synthesis and chromatin remodeling are discussed in the following three chapters. Next, more attention is given to the mutagenic consequences of failed or aberrant DNA repair, particularly in mitochondria and in runs of trinucleotide repeats. Moving to a human health-oriented view, the book presents data on two kinds of lesions, the widely found 8-oxoguanine and the dietary genotoxic adducts with aristolochic acids, as biomarkers of general oxidative stress and specific exposure, respectively. Two final chapters are devoted to the interplay of multiple factors, including genotoxic stress, in the complex phenotypes in humans (amyotrophic lateral sclerosis ) and plants (abiotic stress response). This volume will be of significant interest for scientists working in the field of DNA repair as well as for the general biochemistry and molecular biology audience.
    Type of Medium: Online Resource
    Pages: XVI, 220 p. 30 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030412838
    Series Statement: Advances in Experimental Medicine and Biology, 1241
    URL: https://doi.org/10.1007/978-3-030-41283-8
    DOI: 10.1007/978-3-030-41283-8
    DDC: 616.042
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    Cell Biology and Translational Medicine, Volume 6 : Stem Cells: Their Heterogeneity, Niche and Regenerative Potential (2020)
    Cham :Springer International Publishing :
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    Keywords: Stem cells. ; Regenerative medicine. ; Medical genetics. ; Biotechnology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Clinical Genetics. ; Chemical Bioengineering.
    Description / Table of Contents: Addressing variability and heterogeneity of induced pluripotent stem cell-derived cardiomyocytes -- Direct Lineage Reprogramming in the CNS -- Induced pluripotent stem cells for regenerative medicine: Quality control based on evaluation of lipid composition -- Decellularized Adipose Tissue: Biochemical composition, in vivo analysis and potential clinical applications -- Decellularization Concept in Regenerative Medicine -- Synovium-derived mesenchymal stem/ stromal cells and their promise for cartilage regeneration -- Skin stem cells, their niche and tissue engineering approach for skin regeneration -- Neurological regulation of the bone marrow niche -- Homeobox genes and homeodomain proteins: new insights into cardiac development, degeneration and regeneration -- Generation of human stem cell-derived pancreatic organoids (POs) for regenerative medicine.
    Abstract: Much research has focused on the basic cellular and molecular biological aspects of stem cells. Much of this research has been fueled by their potential for use in regenerative medicine applications, which has in turn spurred growing numbers of translational and clinical studies. However, more work is needed if the potential is to be realized for improvement of the lives and well-being of patients with numerous diseases and conditions. This book series 'Cell Biology and Translational Medicine (CBTMED)' as part of SpringerNature’s longstanding and very successful Advances in Experimental Medicine and Biology book series, has the goal to accelerate advances by timely information exchange. Emerging areas of regenerative medicine and translational aspects of stem cells are covered in each volume. Outstanding researchers are recruited to highlight developments and remaining challenges in both the basic research and clinical arenas. This current book is the sixth volume of a continuing series.
    Type of Medium: Online Resource
    Pages: VIII, 223 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030328238
    Series Statement: Cell Biology and Translational Medicine, 1212
    URL: https://doi.org/10.1007/978-3-030-32823-8
    DOI: 10.1007/978-3-030-32823-8
    DDC: 571.6
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    Long Noncoding RNA : Mechanistic Insights and Roles in Inflammation (2022)
    Cham :Springer International Publishing :
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    Keywords: Bioinformatics. ; Medical genetics. ; Immunology. ; Bioinformatics. ; Medical Genetics. ; Medical Genetics. ; Immunology.
    Description / Table of Contents: Section 1: Overview -- Chapter 1: Introduction and overview -- Section 2: Basics of long noncoding RNA Classifications and functions -- Chapter 2: The Complexity of the Mammalian Transcriptome -- Chapter 3: Towards molecular mechanism in long non-coding RNAs: linking structure and function -- Section 3: Long noncoding RNA and inflammation -- Chapter 4: Long noncoding RNAs in Rheumatology -- Chapter 5: LncRNA and Cardiovascular Disease -- Chapter 6: A role for lncRNAs in regulating inflammatory and autoimmune responses underlying type 1 diabetes -- Section 4: Long noncoding RNAs as Therapeutic targets -- Chapter 7: LncRNA Biomarkers of Inflammation and Cancer -- Chapter 8: Functional Implications of Intergenic GWAS SNPs in Immune Related lncRNAs -- Chapter 9: Long noncoding RNAs as Therapeutic Targets -- Section 5: Challenges and Future Directions -- Chapter 10: Challenges and future directions for LncRNAs and inflammation.
    Abstract: This book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.
    Type of Medium: Online Resource
    Pages: IX, 189 p. 12 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030920340
    Series Statement: Advances in Experimental Medicine and Biology, 1363
    URL: https://doi.org/10.1007/978-3-030-92034-0
    DOI: 10.1007/978-3-030-92034-0
    DDC: 570.285
    Language: English
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    Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Biology Technique. ; Genetics. ; Medical Genetics. ; Experimental Organisms. ; Genetics and Genomics.
    Description / Table of Contents: Early eye development: Specification and Determination -- Generation of third dimension: Axial patterning in the developing Drosophila eye -- Catching the Next Wave: Patterning of the Drosophila eye by the Morphogenetic Furrow -- Ghost in the Machine- the Peripodail Epithelium -- Cell Polarity in Drosophila Retina -- Negative regulation for neural patterning in the Drosophila eye -- Adhesion and the cytoskeleton in the Drosophila pupaleye -- Drosophila eye as a model to study regulation of growth control: The discovery of size control pathways -- Drosophila cancer modeling using the eye imaginal discs -- Recent contributions of the Drosophila eye to unraveling the basis of neurodegeneration -- Genetic regulation of early eye development in non-dipteran insects -- Eyes for an eye: A comparative account on compound eye of Drosophila melanogaster with vertebrate eye -- Index.
    Abstract: Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.
    Type of Medium: Online Resource
    Pages: XIV, 368 p. 81 illus., 73 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030422462
    URL: https://doi.org/10.1007/978-3-030-42246-2
    DOI: 10.1007/978-3-030-42246-2
    DDC: 616.042
    Language: English
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    A Handbook of Gene and Cell Therapy (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Molecular genetics. ; Genetics. ; Medical Genetics. ; Clinical Genetics. ; Molecular Genetics. ; Genetics and Genomics.
    Description / Table of Contents: 1. Gene and Cell therapy overview -- 2. Gene and Cell therapy history -- 3. Delivery systems for gene therapy -- 4. Stem-cells and tissue regeneration theories -- 5. Gene therapy strategies -- 6. Gene and cell therapy applications -- 7. Gene therapy clinical trials -- 8. Research in gene therapy: celllular and animal models -- 9. Future challenges in gene and cell therapy.
    Abstract: This is a reference handbook for young researchers exploring gene and cell therapy. Gene therapy could be defined as a set of strategies modifying gene expression or correcting mutant/defective genes through the administration of DNA (or RNA) to cells, in order to treat disease. Important advances like the discovery of RNA interference, the completion of the Human Genome project or the development of induced pluripotent stem cells (iPSc) and the basics of gene therapy are covered. This is a great book for students, teachers, biomedical researchers delving into gene/cell therapy or researchers borrowing skills from this scientific field.
    Type of Medium: Online Resource
    Pages: XI, 188 p. 67 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030413330
    URL: https://doi.org/10.1007/978-3-030-41333-0
    DOI: 10.1007/978-3-030-41333-0
    DDC: 616.042
    Language: English
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  • 57
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    Biotechnologies for Gene Therapy : RNA, CRISPR, Nanobots, and Preclinical Applications (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Biomedical engineering. ; Biotechnology. ; Pharmaceutical chemistry. ; Medical Genetics. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Pharmaceutics.
    Description / Table of Contents: 1. Therapeutic potential of microRNAs and their nanoparticle-based delivery in the treatment of liver fibrosis -- 2. MicroRNA as a versatile regulator of Wnt signaling pathway in colorectal cancer -- 3. Small Activating RNA Therapy for Angiogenesis -- 4. Muscular dystrophy therapy using viral vector-based CRISPR/Cas -- 5. CRISPR-Cas based gene therapy to target viral infections -- 6. CRISPR targeting the integrated HTLV-1 virus -- 7. Retroviral vectors for gene therapy of monogenic diseases -- 8. DNA Origami Nanodevices for Therapeutic Delivery Applications.
    Abstract: The purpose of this book is to highlight some of latest developments and applications of CRISPR, RNA, and DNA to treat diseases ranging from cancers to cardiovascular and degenerative disorders. It also features innovations of the delivery methods for nucleic acids ranging from nanodevices made from DNA and pseudo amino acids to viral vectors. This is an ideal book for academics, clinicians, and students interested in gene therapy.
    Type of Medium: Online Resource
    Pages: IX, 203 p. 26 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030933333
    URL: https://doi.org/10.1007/978-3-030-93333-3
    DOI: 10.1007/978-3-030-93333-3
    DDC: 616.042
    Language: English
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    Human Interphase Chromosomes : Biomedical Aspects (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Molecular genetics. ; Cytology. ; Medical Genetics. ; Molecular Genetics. ; Cell Biology.
    Description / Table of Contents: Human Interphase Cytogenomics -- Eukaryotic genome in three dimensions -- Analysis of cell and nucleus genome by Next-Generation Sequencing -- Interphase Chromosomes of the Human Brain -- Senescence and the Genome -- Unclassified Chromosome Abnormalities and Genome Behavior in Interphase -- 21st century FISH: focus on interphase chromosomes -- Chromosome architecture studied by high resolution FISH-banding in three dimensionally preserved human interphase nuclei -- Chromosome-centric Look at the Genome -- Index.
    Abstract: This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.
    Type of Medium: Online Resource
    Pages: XII, 178 p. 39 illus., 34 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030625320
    URL: https://doi.org/10.1007/978-3-030-62532-0
    DOI: 10.1007/978-3-030-62532-0
    DDC: 616.042
    Language: English
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    Human Genome Structure, Function and Clinical Considerations (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical sciences. ; Genetics. ; Medical genetics. ; Medicine Research. ; Biology Research. ; Health Sciences. ; Genetics and Genomics. ; Medical Genetics. ; Biomedical Research.
    Description / Table of Contents: Overview of the Human Genome -- Human Chromosomes -- Methods to study genomic DNA Sequence Variation -- Protein-coding Genes -- Non-coding Gene Families of the Human Genome -- Human Satellite DNA -- DNA Simple Tandem Repeats -- Human Chromosome Telomeres -- Interspersed Transposable Elements -- Copy Number Variation in the Human Genome -- The Human Mitochondrial Genome -- The Human Mitochondrial Genome.
    Abstract: This book provides a detailed evidence-based overview of the latest developments in how the structure of the human genome is relevant to the health professional. It features comprehensive reviews of genome science including human chromosomal and mitochondrial DNA structure, protein-coding and noncoding genes, and the diverse classes of repeat elements of the human genome. These concepts are then built upon to provide context as to how they functionally relate to differences in phenotypic traits that can be observed in human populations. Guidance is also provided on how this information can be applied by the medical practitioner in day-to-day clinical practice. Human Genome Structure, Function and Clinical Considerations collates the latest developments in genome science and current methods for genome analysis that are relevant for the clinician, researcher and scientist who utilises precision medicine techniques and is an essential resource for any such practitioner.
    Type of Medium: Online Resource
    Pages: VIII, 361 p. 52 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030731519
    URL: https://doi.org/10.1007/978-3-030-73151-9
    DOI: 10.1007/978-3-030-73151-9
    DDC: 610
    Language: English
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    Single Nucleotide Polymorphisms : Human Variation and a Coming Revolution in Biology and Medicine (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Cytology. ; Bioinformatics. ; Medical Genetics. ; Cell Biology. ; Bioinformatics.
    Description / Table of Contents: SECTION I -- Chapter 1: Evolutionary Forces that Generate SNPs -- Chapter 2: Conserved SNPs: Providing Answers to Fundamental Questions in Human Biology -- Chapter 3: SNPs Classification and Terminology -- SECTION II -- Chapter 4: SNPs Ability to Influence Disease Risk -- Chapter 5: GWAS to Identify SNPs Associated with Common Diseases and Individual Risk -- SECTION III -- Chapter 6: A Case Study of Molecular Mechanisms by Which Non-Synonymous SNPs Alter Protein Structure and Function -- Chapter 7: A Case Study of Molecular Mechanisms by Which Synonymous SNPs Alter Protein Structure and Function -- SECTION IV -- Chapter 8: Using Genome-Wide Studies to Study Synonymous Codons -- Chapter 9: Bioinformatics Tools for Identification of SNPs -- Chapter 10: Bionformatic Tools for Predicting SNPs Effects on Gene Function and Phenotype -- Chapter 11: New Biophysical Techniques for Single mRNA Molecule Measurements -- Chapter 12: Emerging Mechanisms by Which Synonymous Mutations Affect Protein Folding, Protein Function and Physiological Changes -- SECTION V -- Chapter 13: SNPs and Personalized Medicine -- Chapter 14: Distribution of SNPs Associated with Personality Traits -- Chapter 15: Condon Optimization.
    Abstract: This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research. As SNP technologies have evolved from labor intensive, expensive, time-consuming processes to relatively inexpensive methods, SNP discovery has exploded. In terms of human biology, this research, particularly since the completion of the Human Genome Project, has provided a detailed understanding of evolutionary forces that have generated SNPs. It also has shown how SNPs shape human variation. The ability to inexpensively generate and analyze vast amounts of genetic data is poised to transform our understanding of human evolution and biology. “Single Nucleotide Polymorphisms” covers a broad survey of SNPs and their classification into synonymous and non-synonymous; the role of SNPs in human disease; case studies providing specific examples of synonymous and non-synonymous SNPs associated with human diseases or affecting therapeutic interventions; mechanisms by which synonymous mutations affect protein levels or protein folding which affect human physiology and response to therapy; and the role of SNPs in personalized medicine. Understanding what SNPs are, how they have been shaped is necessary for an increasingly expanding audience. This research will revolutionize the future of medicine. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. SNPs Ability to Influence Disease Risk: Breaking the Silence on Synonymous Mutations in Cancer" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVIII, 234 p. 23 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031056161
    URL: https://doi.org/10.1007/978-3-031-05616-1
    DOI: 10.1007/978-3-031-05616-1
    DDC: 616.042
    Language: English
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    Cancer Stem Cell Markers and Related Network Pathways (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Medical microbiology. ; Biomedical Research. ; Biomedical Research. ; Medical Genetics. ; Medical Microbiology.
    Description / Table of Contents: 1. Epithelial-mesenchymal transition and cancer stem cells -- 2. The transcription factors Zeb1 and Snail induce cell malignancy and can-cer stem cell phenotype in prostate cells, increasing androgen synthesis ca-pacity and therapy resistance -- 3. ERBB signaling pathway in cancer stem cells -- 4. Functional and molecular characters of cancer stem cells through devel-opment to establishment -- 5. Microenvironment in cancer stem cells -- 6. Cancer stem cells contribute to drug resistance in multiple different ways -- 7. Abnormal glycosylation in cancer cells and cancer stem cells as a thera-peutic target.
    Abstract: This book entitled “Cancer Stem Cell Markers and Related Network Path-ways” is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype. This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways. The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters. The topic of this book is particularly relevant to research in the field of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.
    Type of Medium: Online Resource
    Pages: XIV, 156 p. 23 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031129742
    Series Statement: Advances in Experimental Medicine and Biology, 1393
    URL: https://doi.org/10.1007/978-3-031-12974-2
    DOI: 10.1007/978-3-031-12974-2
    DDC: 610.72
    Language: English
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