ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Books  (31)
  • Medical genetics.  (31)
  • Cham :Springer International Publishing :  (31)
  • 616.042  (24)
  • 610.72  (7)
  • 1
    Online Resource
    Online Resource
    Beyond Our Genes : Pathophysiology of Gene and Environment Interaction and Epigenetic Inheritance (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Genetics. ; Biotechnology. ; Medical Genetics. ; Genetics and Genomics. ; Chemical Bioengineering.
    Description / Table of Contents: Section I: The physiology of the gene/environment interaction -- Nutrition -- Physical Exercise -- Circadian Rhythm -- Toxicants: Smoke, Alcohol and Heavy Metals -- Hormones -- Section II: Gene-Environment Interaction and Disease Susceptibility -- Obesity and Metabolic Syndromes -- Cancer -- Neurological and Psychiatric Disorders -- Asthma and allergic disorders -- Lamarck Versus Darwin: The Concept of Aquired Epigenetic Inheritance -- Section III: Genome/Epigenome -- Genetic Contribution to Epigenetic Inheritance -- The Controversial Role of DNA Methylation in Epigenetic Inheritance -- Small Non-Coding RNAs -- Chromatin Modifiers -- Soma-to-Germline Information Transfer: Questions and Promises.
    Abstract: The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.
    Type of Medium: Online Resource
    Pages: VIII, 266 p. 11 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030352134
    URL: https://doi.org/10.1007/978-3-030-35213-4
    DOI: 10.1007/978-3-030-35213-4
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 2
    Online Resource
    Online Resource
    Druggable Lipid Signaling Pathways (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Medical genetics. ; Cancer. ; Lipids. ; Biomedical Research. ; Pharmacology. ; Medical Genetics. ; Cancer Biology. ; Lipidology.
    Description / Table of Contents: Preface -- Introduction of Druggable Lipid Signaling Pathway -- Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development -- Druggable Prostanoid Pathway -- Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress -- Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation -- Druggable Sphingolipid Pathway -- Druggable Lysophospholipid Pathway -- Druggable targets in endocannabinoid signaling -- Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections -- Druggable Lipid GPCRs: Past, Present, and Prospects. .
    Abstract: This edited work presents a series of reviews focusing on Druggable Lipid Signaling Pathways. It enables researchers in both academic institutions and industry as well as physicians to understand historical aspects of lipid signaling and future directions of drug discovery targeting lipid signaling pathways. This book provides 9 pathways including acyltransferases, prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, phosphoinositides, and lipid GPCRs. Readers will discover the importance of each lipid signaling pathway that contributes to broad range of diseases including neurological and neuropsychiatric diseases, pain, metabolic syndromes, cardiovascular diseases, cancer, dermatological diseases, fibrosis, inflammation, etc. Also, readers will recognize that many drugs targeting lipid signaling have been clinically used. Drugs currently under development are also discussed in each chapter, which includes some information about clinical trials and strategic drug designs. .
    Type of Medium: Online Resource
    Pages: VI, 260 p. 33 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030506216
    Series Statement: Advances in Experimental Medicine and Biology, 1274
    URL: https://doi.org/10.1007/978-3-030-50621-6
    DOI: 10.1007/978-3-030-50621-6
    DDC: 610.72
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 3
    Online Resource
    Online Resource
    Messenger RNA Therapeutics (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Medicinal chemistry. ; Nanomedicine. ; Cancer Treatment. ; Medical Genetics. ; Medicinal Chemistry. ; Nanomedicine and Nanotoxicology. ; Cancer Therapy.
    Description / Table of Contents: The Democratization of RNA Therapeutics -- Supramolecular Strategies for mRNA Delivery -- In Vitro-Transcribed mRNAs as a New Generation of Therapeutics in the Dawn of 21st Century: Exploitation of Peptides as Carriers for their Intracellular Delivery -- Effective Delivery of mRNA Therapeutics and Vaccines Using Lipid Nanoparticles -- Messenger RNA Therapeutics -- Formulation, Delivery and Application of mRNA Therapeutics In Respiratory Diseases -- Clinical Applications of mRNA Formulated In Lipid Nanoparticles -- Preparation of Messenger RNA Loaded Nanomedicine Applied on Tissue Engineering And Regenerative Medicine -- Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics: Immune Activation By Ionizable Cationic Lipids -- Adjuvants, the Elephant in the Room for RNA Vaccines -- Addressing Skin with Modified mRNA Constructs for Novel Therapies -- mRNA-Based Cancer Immunotherapies -- From Bench to Bedside: The Journey of an mRNA Drug Candidate Into a Medicine -- Synthetic mRNA Gene Therapies for Chronic HBV Infection -- Delivery Vehicles for Self-Amplifying RNA -- Delivery Technologies of mRNA Vaccines -- Nanosystems: The Key in Formulations of mRNA for Several Pathologies -- Messenger RNA Nanoformulation For Cancer Vaccine -- Preparation of Synthetic mRNAs for In Vivo Applications – Overview and Considerations -- Messenger RNA for Prophylaxis -- Nuclear Export of mRNA with Disease Pathogenesis and Therapeutic Potentials -- Messenger RNA Therapeutics: Start of a New Era in Medicine -- mRNA Delivery Technologies for Therapeutic Applications.
    Abstract: This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics.
    Type of Medium: Online Resource
    Pages: XII, 446 p. 68 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031084157
    Series Statement: RNA Technologies, 13
    URL: https://doi.org/10.1007/978-3-031-08415-7
    DOI: 10.1007/978-3-031-08415-7
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 4
    Online Resource
    Online Resource
    Clinical Genetics and Genomics of Aging (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Medical Genetics.
    Description / Table of Contents: Chapter 1: An Update On The Molecular Pillars Of Aging -- Chapter 2: Age-related Neurodegenerative Diseases: An Update -- Chapter 3: Molecular Aspects Of Hippocampal Aging -- Chapter 4: Mitochondrial Function in Aging -- Chapter 5: Genomic Tools Used in Molecular Clinical Aging Research -- Chapter 6: Molecular Biomarkers of Aging Studies in Humans -- Chapter 7: Alternative Splicing and Aging -- Chapter 8: Epigenetics and Aging -- Chapter 9: Microbiome Research and Aging -- Chapter 10: Molecular Basis of Progeroid Diseases -- Chapter 11: Applications of CRISPR-Cas in Aging Research -- Chapter 12: Pharmacological Treatment for Aging: Are We There? -- Chapter 13: Integrative Outlooks About Clinical and Biomedical Research in Aging.
    Abstract: The world population is rapidly aging—it is estimated that by 1950, around 17% of the population will be elderly. In this context, aging involves several physiological, psychological and highly complex social processes that vary from one person to another. For a long time, medical care for older adults has focused on treating chronic, age-related diseases and their associated consequences. Recently, biomedical research brings a novel point of view to develop more effective interventions by targeting the aging process itself rather than separate conditions. There is a growing number of reports indicating that aging is driven by several interconnected mechanisms and biological components referred to as the molecular pillars of aging. Interfering with these mechanisms could help to treat, prevent, and understand the development of age-related diseases and associated syndromes. This book provides a clinical perspective and general update on biomedical and genetic research in aging, moving from an update in the molecular pillars of aging to a perspective of the most recent pharmacological, clinical, and diagnostic applications using genomic approaches and techniques. While this book focuses on the specifics of genetics and genomics, it also adopts a clinical perspective of geroscience, which seeks to understand the genetic, molecular and cellular mechanisms that make aging an important risk factor and, sometimes, a determining factor in the diseases and common chronic conditions of older people. Additionally, Clinical Genetics and Genomics of Aging is a significant contribution to support aging research, as it shows that collaboration across disciplines is relevant to progress in the field. As more and more people benefit from increased longevity, clinician and researchers will be empowered by this knowledge to contribute to the progress of aging research.
    Type of Medium: Online Resource
    Pages: XV, 271 p. 12 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030409555
    URL: https://doi.org/10.1007/978-3-030-40955-5
    DOI: 10.1007/978-3-030-40955-5
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 5
    Online Resource
    Online Resource
    GeNeDis 2018 : Computational Biology and Bioinformatics (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: S-MEDUTA: Combining Balanced Scorecard with simulation and MCDA techniques for the evaluation of the strategic performance of an Emergency Department -- An Architecture For Cooperative Mobile Health Applications -- An Educational Scenario for the Learning of the Conic Section: Studying the Ellipse with the Use of Digital Tools and Elements of Differentiated Instruction and Cognitive Neurosciences 45 -- Antibody clustering using a machine learning pipeline that fuses genetic, structural and physicochemical properties -- Neuroeducation and computer programming. A review -- Towards Analyzing Next Generation Sequencing Algorithms -- WOL Ecosystem: Secure remote power-state control of computer(s) over the internet for telemedicine purposes and dementia patients -- Epidemics Fuzzy Decision-Making Applications and Fuzzy Genetic Algorithms Efficiency Enhancement -- Multivariate data analysis and machine learning for prediction of MCI-to-AD conversion -- A Deep Learning Approach for Human Action Recognition using Skeletal Information -- Artificial Neural Networks in Computer Aided Drug Design. An overview of recent advances -- Computation of dolphins’ sound aspl while foraging -- Novel cost function definition for minimum-cost Tractography in MR Diffusion Tensor Imaging -- Platform for managing medical data by using a passive electronic device -- Evaluation of a computerized cognitive screening tool (ADPS, Altoida) in a sample of community-dwelling older adults -- Interconnections and Modeling Schemes of Kinesia Paradoxa -- Knowledge Discovery on IoT-enabled mHealth Applications -- Computational approaches applied in the field of neuroscience -- Drugena: A fully automated immunoinformatics platform for the design of antibody drug conjugates against neurodegenerative diseases -- Brain-Computer Interface Design and Neurofeedback Training in the case of ADHD Rehabilitation -- Particular biomolecular processes as computing paradigms -- Decision trees and applications -- Utilization of new technologies in the production of pharmaceutical olive oil -- A survey of evolutionary games in biology -- DTCo: An ensemble SSL algorithm for X-rays classification -- Cognitive Enhancement and Brain-Computer Interfaces. Potential Boundaries and Risks -- Informatics and cognitive assessment: a RUDAS scale paradigm -- Effective stochastic algorithm in disease prediction -- A Systems Biology Approach for the Identification of Active Molecular Pathways during the Progression of Alzheimer’s Disease -- A brief survey of the Prisoners' Dilemma game and its potential use in biology -- Validation of modeling and simulation methods in computational biology -- An improved self-labeled algorithm for cancer prediction -- eHealth application for e-bloodanalysis, e-diagnosis and digital diet guidance -- Modeling the critical activation of chaperone machinery in protein folding -- ANTISOMA: A computational pipeline for the reduction of the aggregation propensity of monoclonal antibodies -- A microscale mathematical blood flow model for understanding cardiovascular diseases -- Blockchain For Mobile Health Applications Acceleration With GPU Computing -- Finite Size Effects in Networks of Coupled Neurons -- Detecting common pathways and key molecules of Neurodegenerative Diseases from the topology of molecular networks -- Robotic Systems involved in the diagnosis of Neurodegenerative diseases -- Undergraduate Students’ Brain Activity in Visual and Textual Programming -- Fuzzy logic Systems and Medical Applications -- Apache Spark Implementations for String Patterns in DNA Sequences -- Big Data Analysis and Genetic Liability to Neuropsychiatric Disease -- Mathematical models and computer simulation of chemical carninogenesis process and its inhibition by antocarcinogenic substances -- Transitioning knowledge levels through problem-solving methods -- Cellular phone user’s age or the duration of calls moderate autonomic nervous system? A meta-analysis -- Logical Analysis and Validation of Publications in Bioinformatics.
    Abstract: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people. .
    Type of Medium: Online Resource
    Pages: XIII, 508 p. 129 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030326227
    Series Statement: Advances in Experimental Medicine and Biology, 1194
    URL: https://doi.org/10.1007/978-3-030-32622-7
    DOI: 10.1007/978-3-030-32622-7
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 6
    Online Resource
    Online Resource
    Tissue-Specific Cell Signaling (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Human physiology. ; Cytology. ; Medicine Research. ; Biology Research. ; Medical Genetics. ; Human Physiology. ; Cell Biology. ; Biomedical Research.
    Description / Table of Contents: Preface -- Tissue-specific cell signaling: introduction -- Beyond the brain signaling -- Cell signaling within pituitary, the master gland of the endocrine system -- Cell signaling within endocrine glands: thyroid, parathyroids and adrenal glands -- Signaling pathways governing activation of innate immune cells -- Cell activation and signaling in lymphocytes -- Signaling pathways involved in kidney and urinary tract physiology and pathology -- More than androgens: hormonal and paracrine signaling in prostate development and homeostasis -- Testicular signaling: team work in sperm production -- Sperm signaling specificity: from sperm maturation until oocyte recognition -- Hormone signaling pathways in the postnatal mammary gland -- Oogenesis signaling: from development to environmental plasticity and aging -- Key signaling pathways in the cardiovascular system -- Growth factor signaling in the maintenance of adult lung homeostasis -- The signaling pathways involved in the regulation of skeletal muscle plasticity -- Adipocyte-specific signaling.
    Abstract: Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVIII, 436 p. 51 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030444365
    URL: https://doi.org/10.1007/978-3-030-44436-5
    DOI: 10.1007/978-3-030-44436-5
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 7
    Online Resource
    Online Resource
    Treasure Your Exceptions : The Science and Life of William Bateson (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Medicine History. ; Life sciences. ; Biology Philosophy. ; Evolution (Biology). ; Biomaterials. ; Nucleic acids. ; Medical Genetics. ; History of Medicine. ; Life Sciences. ; Philosophy of Biology. ; Evolutionary Biology. ; Nucleic Acid.
    Description / Table of Contents: Abbreviations -- Prologue -- Part I. Genesis of a Geneticist -- 1 A Cambridge Childhood (1861-1882 -- 2 From Virginia to the Aral Sea (1883-1889) -- 3 Galton -- 4 Variation (1890-1894) -- 5 Romanes -- 6 Reorientation and Controversy (1895-1899) -- 7 What Life May Be -- Part II. Mendelism -- 8 Rediscovery (1900-1901) -- 9 Mendel’s Bulldog (1902-1906) -- 10 Bateson’s Bulldog -- 11 On Course (1907-1908) -- 12 Darwin Centenary (1909) -- 13 Chromosomes -- Part III. The Innes Years -- 14 Passages (1910-1914) -- 15 Eugenics -- 16 War (1915-1919) -- 17 My Respectful Homage (1920-1922) -- 18 Limits Undetermined (1923-1926) -- Part IV. Politics -- 19 Butler -- 20 Pilgrimages -- 21 Kammerer -- 22 Science and Chauvinism -- 23 Degrees for Women -- Part V. Eclipse -- 24 Bashing -- 25 Epilogue -- Part VI. Further Rediscovery -- 26 The Third Base -- 27 Mendel Basics -- 28 Romanes, Bateson, and Darwin's "Weak Point" -- 29 Bateson's Residue: Oligonucleotide Disharmony -- Publications of William Bateson -- References and Notes -- Acknowledgements -- Index.
    Abstract: William Bateson brought the work of Mendel (and much more) to the attention of the English-speaking world. He commanded the biological sciences in the decades after Darwin's death in 1882. To understand these years we must first understand Bateson. Through examination of the life of a major contributor to the turn-of-the-nineteenth-century revolution in biology, the authors reconcile the genocentrism of George Williams and Richard Dawkins with the hierarchical thinking of Richard Goldschmidt and Stephen Jay Gould. Aided by Rebecca Saunders, Bateson invented much of the basic terminology of modern genetics and, when addressing Darwin's great problem – the origin of species, introduced the mysterious term "the residue." While the first edition of this work (2008) related "residue" to relative concentrations of bases in DNA, the second edition reveals this as reflecting fundamental differences in short strings of bases. Thus, the book has come to represent not only Bateson’s science and life, but also a revised history of the biosciences that is likely to be increasingly visited, both by scientists and by those who wish to fully understand contemporary debates on racial, eugenic and gender aspects of genetics. In a nutshell, the book describes what we, in modern terms, would call a "colossal intelligence failure." Mendel handed it to us "on a plate" in 1865 when Bateson was only 4. It took 35 years to "join the dots" with Bateson a primary joiner. Shrugged off by many 20th century scientists as a freak "blip" in what was really an orderly advance, the Mendel episode was but one of a succession of such "blips." Thus, a multiplicity of post-Mendelian "Mendels" emerge as the story of Bateson's life unfolds. Peter Harper in Human Genetics (2009): "This book puts the record straight and one is left with a feeling of admiration for Bateson as both a scientist and a man, and with no doubt that he, more than anyone else, was largely responsible for the rapid progress in modern genetics during the first decade of the twentieth century." Michael J. Wade in Evolution (2009): "I strongly recommend this book for its information on an important central figure and for its bringing to life the several controversies at the origins of Genetics. It greatly illuminates the conceptual foundations of evolutionary genetics." Elof Axel Carlson in Quarterly Review of Biology (2009): "This volume will be of enormous benefit to historians of science who like to follow how ideas are born or die and why participants of different sides of each controversy held such rigid views of their own work and saw little merit in their competitor’s research." Joel S. Schwartz in Choice (2009): "This work includes key events in Bateson's career and is strengthened by discussion of the rediscovery of Mendelian principles by early 20th-century geneticists. Its basic premise is that Bateson was not merely one of the founders of genetics but played a pivotal role in the development of evolutionary biology by serving as the link between Victorian naturalists and early 20th-century biologists." Amitabh Joshi in Journal of Genetics (2010): "There is much in this book that I was not aware of, despite a formal training in genetics and a strong amateur interest in the history of biology.… It is certainly a book that any serious student of either genetics or evolution would greatly benefit from reading." .
    Type of Medium: Online Resource
    Pages: XXXIX, 688 p. 59 illus., 9 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030920999
    URL: https://doi.org/10.1007/978-3-030-92099-9
    DOI: 10.1007/978-3-030-92099-9
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 8
    Online Resource
    Online Resource
    Progress in Heritable Soft Connective Tissue Diseases (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Physiology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Physiology. ; Internal Medicine.
    Description / Table of Contents: Basic structure, physiology and biochemistry of connective tissues and extracellular matrix collagens -- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life -- Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins -- Proteoglycans and Diseases of Soft Tissues -- Growth Factor Roles in Soft Tissue Physiology and Pathophysiology -- Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling -- The Pathophysiology and Pathogenesis of Marfan Syndrome -- Ehlers-Danlos syndromes, joint hypermobility and hypermobility spectrum disorders -- Ehlers–Danlos Syndrome Associated with Glycosaminoglycan Abnormalities -- Loeys-Dietz Syndrome -- Meester-Loeys syndrome -- Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Elastic Fiber Homeostasis -- Collagen VI Muscle Disorders: Mutation Types, Pathogenic Mechanisms and Approaches to Therapy -- Connective Tissue Disorders in Domestic Animals.
    Abstract: This volume represents a substantially revised and updated 2nd edition of a reference handbook on major structural components of soft connective tissues and a whole slew of heritable diseases of soft connective tissues. The number of clearly identifiable and distinct disorders has grown somewhat since the 1st edition in 2014, e.g., Ehlers-Danlos syndrome has now 13 entities. A brand new syndrome, Meester Loeys syndrome carrying the name of Bart Loeys was added as a companion to Loeys-Dietz syndrome. Numerous variations of cutis laxa and joint mobility disorders have been discovered taking advantage of recent advancements in genetic analysis. We have acquired better understanding of pathogenesis and biochemical changes in some other, more established entities, such as Marfan and collagen VI myopathies where better management and possible treatment are on the horizon. Even in the case of connective tissue diseases in domestic animals some progress has been made. All these updates were contributed by a group of distinguished and preeminent physicians and scientists, all of them not just working in the field but making new discoveries described by them. Readers will notice that seemingly there is an overlap among many of these disorders. And indeed, many of them, if not most are interconnected because of the prominent roles of TGFβ, of fibrillin microfibrils and collagen fibril assembly (and other molecules) playing in connective tissues physiology, and by extension in pathogenesis of many disorders described in the book. What I found particularly helpful that author(s) of each chapter bring their own perspective even when described closely related mechanism of the disease. These observations should help with diagnosis and management of such cases. The first chapters are more general, concentrating more on the physiology, structure and biochemistry of normal soft tissues. That should help in better understanding of the pathophysiology. Last but not least, the chapters are very readable, more like detective stories than dry description of genetic/biochemical defects. I do hope that basic scientists and clinicians with similar and diverse interests alike will appreciate this volume and will be inspired by it to develop their research in the field.
    Type of Medium: Online Resource
    Pages: IX, 343 p. 1 illus. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030806149
    Series Statement: Advances in Experimental Medicine and Biology, 1348
    URL: https://doi.org/10.1007/978-3-030-80614-9
    DOI: 10.1007/978-3-030-80614-9
    DDC: 610.72
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 9
    Online Resource
    Online Resource
    GeNeDis 2020 : Geriatrics (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Stratification of patients with Chronic Obstructive Pulmonary Disease using Volatile Organic Compounds -- 2-Evidence-based Leadership: A Study of its Application to General Hospital of the Public Health System through the Implementation Leadership Scale -- 3-Greek nurses’ perception of hospital ethical climate. A cross-sectional study -- 4-Investigating the main causes of conflicts and the managements strategies are used by healthcare professionals. The case of general hospital of Arta -- 5-Incidence of deep vein thrombosis and its effect on health related quality of life among nurses of Greek public hospital. A multicenter study -- 6-Factors affecting anxiety and depression in caregivers of hemodialysis patients -- 7-Hand grip strength in patients on hemodialysis: An observational study -- 8-The effect of spirituality on illness perceptions in patients undergoing hemodialysis -- 9-Validation of the STOP-Bang Questionnaire in Greek patients suffering from obstructive sleep apnea -- 10-The role of Pythagorean Self-Awareness Intervention in obstructive sleep apnea. A randomized controlled trial -- 11-Tissue characterization in Cardiology. Moving beyond function -- 12-Psychiatric care in acute care units with locked doors: Nursing care providers’ perceptions and experiences -- 13-Researching nursing students’ attitudes towards mental health practice: cultural adaptation and validation of the Greek version of the Acceptability of Locking the Door Questionnaire in acute psychiatric care -- 14-Compliance of bronchial asthma patients' with the Mediterranean diet -- 15-Nurses’ experiences of psychiatric care in acute care units with an open door policy -- 16-Validation of the Greek Version of Hedonic, Eudaimonic and Extrinsic Motives for Activities (HEEMA) Instrument -- 17-Event-Related Rumination Inventory: A Validation Process in the Greek Language -- 18-The job rotation of nursing staff and its effects on nurse`s satisfaction and occupational engagement -- 19-The burden on carers with multiple sclerosis -- 20-Attitudes of the general population regarding patient information for a chronic and life-threatening disease. A cross-sectional study -- 21-Assessment of healthcare professionals’ knowledge and awareness on aspects related to ionizing radiation examinations in Athens, Greece -- 22-Medication errors and their correlation with nurse's satisfaction. The case of the hospitals of Lasithi, Crete -- 23-Health-Related Quality of Life and Living Costs of HIV-Infected Patients -- 24-Evaluation of anxiety and depression in women undergoing mastectomy in Greece -- 25-The effect of emotional intelligence on caring behaviors among psychiatric nurses in Greece -- 26-Investigating nursing leadership in intensive care units of hospitals of Northern Greece and its relationship to the working environment -- 27-Health-Related Quality of Life and Rehabilitation Costs of Patients with Amputated Limb -- 28-Anxiety and depression in hemodialysis: Sex differences -- 29-Patient knowledge, adherence to the therapeutic regimen, and quality of life in hemodialysis -- 30-The burden of caregivers of patients after hip replacement and its impact on the cost of living of the family -- 31-The effects of exercise in patients with Sarcopenia -- 32-Fluid dynamics derived parameters in coronary vessels -- 33-Level of knowledge about COPD among patients and caregivers -- 34-Increased body mass index (BMI) and sunscreen use are associated with inadequate vitamin D status in Greek adults in winter -- 35-The effect of whole-body cryostimulation in healthy adults -- 36-Exhaled Nitric Oxide (FeNO) in patients hospitalized for an exacerbation of bronchiectasis and/or COPD -- 37-Formulation and Evaluation of Dermatological product containing Niacinamide -- 38-Exhaled breath condensate and dyspnea in COPD -- 39-The Effects of Pythagorean Self-Awareness Intervention on Irritable Bowel Syndrome Patients: A Non-Randomized Controlled Trial -- 40-Adults’ stress response to unexpected oral and arithmetic tasks in supine position -- 41-Triangles and family engagement in drug and alcohol addiction treatment -- 42-Use of fortified bread for addressing vitamin D deficiency. .
    Abstract: The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The increase in the average length of life leads to the development of various diseases in the elderly population. This volume focuses on the sessions from the conference on Geriatrics.
    Type of Medium: Online Resource
    Pages: XXVII, 389 p. 27 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030787714
    Series Statement: Advances in Experimental Medicine and Biology, 1337
    URL: https://doi.org/10.1007/978-3-030-78771-4
    DOI: 10.1007/978-3-030-78771-4
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 10
    Online Resource
    Online Resource
    Gadd45 Stress Sensor Genes (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Microbial genetics. ; Medical Genetics. ; Medical Genetics. ; Microbial Genetics.
    Description / Table of Contents: GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis -- GADD45 in Development and Cancer -- GADD45 in Normal Hematopoiesis and Leukemia -- GADD45 in DNA Methylation and DNA Repair -- GADD45 Proteins in Immunity -- GADD45 in Liver Function and Cancer -- GADD45 in Pre-Eclampsia -- GADD45 in Senescence -- GADD45 in Neuronal Development, Function, and Injury -- Index.
    Abstract: This second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors. The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved.
    Type of Medium: Online Resource
    Pages: IX, 153 p. 27 illus., 18 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030948047
    Series Statement: Advances in Experimental Medicine and Biology, 1360
    URL: https://doi.org/10.1007/978-3-030-94804-7
    DOI: 10.1007/978-3-030-94804-7
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 11
    Online Resource
    Online Resource
    Human Chromosome Atlas : Introduction to Diagnostics of Structural Aberrations (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Diagnosis. ; Chromosomes. ; Genetic disorders. ; Genetic counseling. ; Medical Genetics. ; Diagnosis. ; Chromosomes. ; Genetic Service.
    Description / Table of Contents: Introduction: Social Attitude towards Disabled People in Different Areas and Cultures -- Role of Ethics Committees -- International Quality Control in the Field of Diagnostics -- Structural Chromosom Abarrations -- Mutations in Non-coding DNA Regions. Single Case Presentations of Intrachromosomal Rearrangements: Inversions -- Deletions -- Duplications -- Ring Chromosomes -- Isochromosomes. Single Case Presentations of Interchromosomal Rearrangements: Translocations -- Insertions -- Complex Chromosome Rearrangements (CCR) -- Marker Chromosomes -- Cases of Intra- and Interchromosomal Mutation in Polymorphic Regions. Guidelines to Clinical Questions and Practical Approaches: Genetic Counselling Procedures -- Life of Persons with Chromosomal Disorders -- Support Groups for Chromosomal Disorders -- Diagnosis and Therapy -- Outlook.
    Abstract: Now in its second edition, this atlas serves as an easy-to-use diagnostic guide for the analysis of the human karyotype. Split in four parts, it starts with a comprehensive introduction covering the molecular cytogenetic basics, the role of ethic committees and international quality control in the field of diagnostics. The main parts II and III, demonstrate the spectrum of the different types of chromosome abnormalities by a combination of karyogram and ideogram, it compares the expressiveness of different banding techniques, and it gives the karyotype formula and describes morphological peculiarities of each presented case. The final part, provides a detailed description of variants of non-coding DNA and focuses on potential problems in detecting aberrations and mentions necessary additional investigations and peculiarities, which have to be taken into account when counseling carriers of a chromosome aberration or their relatives. Given its comprehensive scope and practical approach, this atlas is an indispensable resource for researchers, clinicians and practitioners working in the field of cytogenetics and clinical genetics.
    Type of Medium: Online Resource
    Pages: XI, 388 p. 98 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031105883
    URL: https://doi.org/10.1007/978-3-031-10588-3
    DOI: 10.1007/978-3-031-10588-3
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 12
    Online Resource
    Online Resource
    Ferroptosis: Mechanism and Diseases (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Cytology. ; Lipids. ; Biomedical Research. ; Medical Genetics. ; Cell Biology. ; Cell Biology. ; Lipidology.
    Description / Table of Contents: Foreword -- Ferroptosis: Concepts and Definitions -- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors -- Iron Homeostasis and Metabolism: Two Sides of a Coin -- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis -- Emerging Role for Ferroptosis in Infectious Diseases -- Small Molecule Regulators of Ferroptosis -- Necroptosis, The other main Caspase-Independent Cell Death.
    Abstract: This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis. While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.
    Type of Medium: Online Resource
    Pages: IX, 140 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030620264
    Series Statement: Advances in Experimental Medicine and Biology, 1301
    URL: https://doi.org/10.1007/978-3-030-62026-4
    DOI: 10.1007/978-3-030-62026-4
    DDC: 610.72
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 13
    Online Resource
    Online Resource
    GeNeDis 2022 : Molecular, Chemical, and Cellular Biology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Stratification of patients with Chronic Obstructive Pulmonary Disease using Volatile Organic Compounds -- 2-Evidence-based Leadership: A Study of its Application to General Hospital of the Public Health System through the Implementation Leadership Scale -- 3-Greek nurses’ perception of hospital ethical climate. A cross-sectional study -- 4-Investigating the main causes of conflicts and the managements strategies are used by healthcare professionals. The case of general hospital of Arta -- 5-Incidence of deep vein thrombosis and its effect on health related quality of life among nurses of Greek public hospital. A multicenter study -- 6-Factors affecting anxiety and depression in caregivers of hemodialysis patients -- 7-Hand grip strength in patients on hemodialysis: An observational study -- 8-The effect of spirituality on illness perceptions in patients undergoing hemodialysis -- 9-Validation of the STOP-Bang Questionnaire in Greek patients suffering from obstructive sleep apnea -- 10-The role of Pythagorean Self-Awareness Intervention in obstructive sleep apnea. A randomized controlled trial -- 11-Tissue characterization in Cardiology. Moving beyond function -- 12-Psychiatric care in acute care units with locked doors: Nursing care providers’ perceptions and experiences -- 13-Researching nursing students’ attitudes towards mental health practice: cultural adaptation and validation of the Greek version of the Acceptability of Locking the Door Questionnaire in acute psychiatric care -- 14-Compliance of bronchial asthma patients' with the Mediterranean diet -- 15-Nurses’ experiences of psychiatric care in acute care units with an open door policy -- 16-Validation of the Greek Version of Hedonic, Eudaimonic and Extrinsic Motives for Activities (HEEMA) Instrument -- 17-Event-Related Rumination Inventory: A Validation Process in the Greek Language -- 18-The job rotation of nursing staff and its effects on nurse`s satisfaction and occupational engagement -- 19-The burden on carers with multiple sclerosis -- 20-Attitudes of the general population regarding patient information for a chronic and life-threatening disease. A cross-sectional study -- 21-Assessment of healthcare professionals’ knowledge and awareness on aspects related to ionizing radiation examinations in Athens, Greece -- 22-Medication errors and their correlation with nurse's satisfaction. The case of the hospitals of Lasithi, Crete -- 23-Health-Related Quality of Life and Living Costs of HIV-Infected Patients -- 24-Evaluation of anxiety and depression in women undergoing mastectomy in Greece -- 25-The effect of emotional intelligence on caring behaviors among psychiatric nurses in Greece -- 26-Investigating nursing leadership in intensive care units of hospitals of Northern Greece and its relationship to the working environment -- 27-Health-Related Quality of Life and Rehabilitation Costs of Patients with Amputated Limb -- 28-Anxiety and depression in hemodialysis: Sex differences -- 29-Patient knowledge, adherence to the therapeutic regimen, and quality of life in hemodialysis -- 30-The burden of caregivers of patients after hip replacement and its impact on the cost of living of the family -- 31-The effects of exercise in patients with Sarcopenia -- 32-Fluid dynamics derived parameters in coronary vessels -- 33-Level of knowledge about COPD among patients and caregivers -- 34-Increased body mass index (BMI) and sunscreen use are associated with inadequate vitamin D status in Greek adults in winter -- 35-The effect of whole-body cryostimulation in healthy adults -- 36-Exhaled Nitric Oxide (FeNO) in patients hospitalized for an exacerbation of bronchiectasis and/or COPD -- 37-Formulation and Evaluation of Dermatological product containing Niacinamide -- 38-Exhaled breath condensate and dyspnea in COPD -- 39-The Effects of Pythagorean Self-Awareness Intervention on Irritable Bowel Syndrome Patients: A Non-Randomized Controlled Trial -- 40-Adults’ stress response to unexpected oral and arithmetic tasks in supine position -- 41-Triangles and family engagement in drug and alcohol addiction treatment -- 42-Use of fortified bread for addressing vitamin D deficiency. .
    Abstract: The 5th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Molecular Biology, Chemical Biology, and Cellular Biology.
    Type of Medium: Online Resource
    Pages: XVIII, 319 p. 137 illus., 132 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031319785
    Series Statement: Advances in Experimental Medicine and Biology, 1423
    URL: https://doi.org/10.1007/978-3-031-31978-5
    DOI: 10.1007/978-3-031-31978-5
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 14
    Online Resource
    Online Resource
    The Immunogenetics of Dermatologic Diseases (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Immunology. ; Dermatology. ; Biomedical Research. ; Medical Genetics. ; Immunology. ; Biomedical Research. ; Dermatology.
    Description / Table of Contents: Genetics control of immune responses -- Non-melanoma skin cancer -- Melanoma -- Psoriasis -- Atopic dermatitis -- Contact dermatitis -- Lichen planus -- Pemphigus and pemphigoids -- Morphea and Lichen Sclerosus -- Granuloma annulare and Necrobiosis lipoidica -- Alopecia areata -- Vitiligo -- Acne Vulgaris and Rosacea -- Urticaria and Angioedema -- Cutaneous drug reaction -- Photodermatologic disorders -- Infantile Haemangioma and other vascular malformations.
    Abstract: This book intends to investigate the broad spectrum of genetic changes in immunological processes involved in cutaneous diseases. One of the main goals of immunogenetic studies is finding susceptibility genes for complex diseases. This can provide an insight into the pathogenesis of the condition in a way that is not easily achievable through other kinds of studies. Thus they are a rational initial step for generating hypotheses about disease pathogenesis. This may especially benefit dermatology, a field notorious for having too many diseases with unknown etiologies. Immunogenetic investigations have made targeted treatment strategies possible for diseases such as psoriasis and pemphigus. Even though these strategies have revolutionized the management of chronic dermatological conditions such as psoriasis, still there are a lot of unanswered questions. For instance, psoriasis patients respond very differently to each of the commercially available biological agents. This diversity could be partially explained by the differences in the sets of genes responsible for disease induction in each individual. Thus whole genome sequencing strategies, if feasible at individual levels, might help in tailoring these targeted treatments based on specific genetic backgrounds. Our intention in preparing this book was to explore the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. We have tried to cover most areas of dermatology where enough studies were available to gather a chapter. Still, there is a substantial lack of knowledge on the immunogenetics of many dermatological conditions. We hope that this book would encourage the investigators to fill these gaps of knowledge.
    Type of Medium: Online Resource
    Pages: XXI, 450 p. 64 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030926168
    Series Statement: Advances in Experimental Medicine and Biology, 1367
    URL: https://doi.org/10.1007/978-3-030-92616-8
    DOI: 10.1007/978-3-030-92616-8
    DDC: 610.72
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 15
    Online Resource
    Online Resource
    Mammalian Sterols : Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Biochemistry. ; Internal medicine. ; Lipids. ; Bioinformatics. ; Medical genetics. ; Biomedical Research. ; Chemical Biology. ; Internal Medicine. ; Lipidology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Sterols from the post-lanosterol part of cholesterol synthesis – novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.
    Abstract: This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.
    Type of Medium: Online Resource
    Pages: V, 171 p. 57 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030396848
    URL: https://doi.org/10.1007/978-3-030-39684-8
    DOI: 10.1007/978-3-030-39684-8
    DDC: 610.72
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 16
    Online Resource
    Online Resource
    Human Brain and Spinal Cord Tumors: From Bench to Bedside. Volume 1 : Neuroimmunology and Neurogenetics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Biomedical Research. ; Biomedical Research. ; Biomedical Research. ; Medical Genetics.
    Description / Table of Contents: Chaptre 1. Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction -- Chaptre 2. Epidemiology of Brain and Spinal Cord Tumors -- Chaptre 3. The Role of Neuro-inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 4. The Role of Cellular Immunity and Adaptive Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 5. Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors -- Chaptre 6. Cell of Origin of Brain and Spinal Cord Tumors -- Chaptre 7. The Role of Bioinformatics and Imaging Models in Tumorigenesis and Treatment Response of Brain and Spinal Cord Neoplasms -- Chaptre 8. The Role of Epigenetics in Brain and Spinal Cord Tumors -- Chaptre 9. Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors -- Chaptre 10. Nutrition and Diet: A Double-Edged Sword in Development and Treatment of Brain Tumors -- Chaptre 11. The Role of Nanotechnology in Brain Tumors -- Chaptre 12. The Role of Nanotechnology in Spinal Cord Tumors -- Chaptre 13. The Economic Burden of Malignant Brain Tumors.
    Abstract: Brain tumors comprise about 5–9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.
    Type of Medium: Online Resource
    Pages: XX, 231 p. 30 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031147326
    Series Statement: Advances in Experimental Medicine and Biology, 1394
    URL: https://doi.org/10.1007/978-3-031-14732-6
    DOI: 10.1007/978-3-031-14732-6
    DDC: 610.72
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 17
    Online Resource
    Online Resource
    The Hereditary Basis of Childhood Cancer (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Medical Genetics. ; Medical Genetics. ; Biomedical Research. ; Pharmacology.
    Description / Table of Contents: 1: Li-Fraumeni Syndrome -- 2: Pediatric Central Nervous System Cancer Predisposition -- 3: Rhabdoid Tumors -- 4: Neurofibromatosis -- 5: Pheochromocytoma and Paraganglioma syndromes -- 6: Wilms tumor -- 7: Hereditary Overgrowth Syndromes -- 8: Multiple Endocrine Neoplasias and Associated Non-Endocrine Conditions -- 9: DICER1 Syndrome -- 10: Cancer-prone Inherited Bone Marrow Failure, Myelodysplastic and Acute Myeloid Leukemia Syndromes -- 11: Inherited Risk for Childhood Leukemia -- 12: Inherited pediatric cancer in low and intermediate resource countries -- 13: Frontline Ethico-legal Issues in Childhood Cancer Genetics Research -- 14: Genetic counseling and testing -- 15: Psychosocial aspects of childhood cancer genetics -- 16: Recognition of cancer predisposition syndromes.
    Abstract: This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the ‘disease-related’ chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where ‘modern’ technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.
    Type of Medium: Online Resource
    Pages: XI, 491 p. 52 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030744489
    URL: https://doi.org/10.1007/978-3-030-74448-9
    DOI: 10.1007/978-3-030-74448-9
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 18
    Online Resource
    Online Resource
    Concepts and Applications of Stem Cell Biology : A Guide for Students (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Stem cells. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Medical Genetics. ; Stem Cell Biology. ; Biomedical Research. ; Biotechnology.
    Description / Table of Contents: Chapter 1: Introduction: a decade teaching stem cell biology -- Chapter 2: Preimplantation development: from germ cells to blastocyst -- Chapter 3: Origins of pluripotency: from stem cells to germ cells -- Chapter 4: Human induced pluripotent stem (hiPS) cells: generation and applications -- Chapter 5: Cellular reprogramming and aging -- Chapter 6: Cloning -- Chapter 7: Stem cells in plant development -- Chapter 8: Axial stem cells and the formation of the vertebrate body -- Chapter 9: Skeletal muscle development - from stem cells to body movement -- Chapter 10: Cardiac regeneration and repair: from mechanisms to therapeutic strategies -- Chapter 11: Reproducing human brain development in vitro: generating cerebellar neurons for modelling cerebellar ataxias -- Chapter 12: Neurotoxicology and disease modelling -- Chapter 13: Mesenchymal stem cells for cutaneous wound healing.
    Abstract: This textbook will support graduate students with learning materials rich in the basic concepts of stem cell biology, in its most widespread and updated perspective. The chapters are conceived in a way for students to understand the meaning of pluripotency, the definition of embryonic stem cells and the formation of multicellular structures such as organoids together with the underlying principles of their epigenetic. This textbook also discusses adult stem cells and the potential use of these cells, in particular neural, mesenchymal, and several types of muscular cells, in biomedical research and clinical applications. This textbook represents a vital complement to the text on Essential Current Concepts of Stem Cell Biology, also published in the Learning Materials in Biosciences textbook series.
    Type of Medium: Online Resource
    Pages: XXII, 267 p. 85 illus., 79 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030439392
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-43939-2
    DOI: 10.1007/978-3-030-43939-2
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 19
    Online Resource
    Online Resource
    Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Molecular genetics. ; Cardiovascular system. ; Physiology. ; Cancer Genetic aspects. ; Biochemical markers. ; Medical Genetics. ; Molecular Genetics. ; Cardiovascular Physiology. ; Cancer Genetics and Genomics. ; Biomarkers.
    Description / Table of Contents: Biogenesis and Modes of Action Of miRs And Circular And Long Non-coding RNAs -- Obesity, Insulin Resistance in Adipose Tissue And Thermogenesis -- Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease -- Atherosclerosis -- Cardiomyopathy and Heart Failure -- Cancer -- Communication between Tumor-Adjacent Tissues and Tumors with Emphasis on Role of Inflammatory Cells -- General Conclusions and Future Perspectives.
    Abstract: This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine. .
    Type of Medium: Online Resource
    Pages: XXX, 265 p. 26 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030688448
    URL: https://doi.org/10.1007/978-3-030-68844-8
    DOI: 10.1007/978-3-030-68844-8
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 20
    Online Resource
    Online Resource
    Age-related Macular Degeneration : From Clinic to Genes and Back to Patient Management (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Ophthalmology. ; Human physiology. ; Medical Genetics. ; Ophthalmology. ; Human Physiology.
    Description / Table of Contents: 1. Age-Related Macular Degeneration: Epidemiology and Clinical Aspects -- 2. Ocular Imaging for Enhancing the Understanding, Assessment, and Management of Age-Related Macular Degeneration -- 3. Histopathology of Age-Related Macular Degeneration and Implications for Pathogenesis and Therapy -- 4. Bruch’s Membrane and the Choroid in Age-Related Macular Degeneration -- 5. Innate Immunity in Age-Related Macular Degeneration -- 6. Immunological Aspects of Age-Related Macular Degeneration -- 7. AMD Genetics: Methods and Analyses for Association, Progression, and Prediction -- 8. Making Biological Sense of Genetic Studies of Age-Related Macular Degeneration -- Age-Related Macular Degeneration: From Epigenetics to Therapeutic Implications -- 10. Mitochondria: The Retina’s Achilles’ Heel in AMD -- 11. Cell-Based Therapies for Age-Related Macular Degeneration -- 12. Current Management of Age-Related Macular Degeneration.
    Abstract: This edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches. AMD is a leading cause of largely incurable blindness worldwide and projected to double from 2.07 million to 5.44 million individuals by 2050 in the United States. Globally, 288 million individuals are projected to have AMD by 2040. The disease has enormous socioeconomic impact on the affected individuals, their families and the society. This book will bring together the state of the art basic science knowledge with clinically relevant findings and address the challenges for future research in AMD. The intersection of different disciplines will provide potential areas for further investigations to reduce the burden of blindness from AMD. This book offers an appealing and insightful resource for clinicians, scientists, students and fellows.
    Type of Medium: Online Resource
    Pages: X, 314 p. 73 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030660147
    Series Statement: Advances in Experimental Medicine and Biology, 1256
    URL: https://doi.org/10.1007/978-3-030-66014-7
    DOI: 10.1007/978-3-030-66014-7
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 21
    Online Resource
    Online Resource
    Diagnostic Genetic Testing : Core Concepts and the Wider Context for Human DNA Analysis (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Diagnosis. ; Bioethics. ; Medical Genetics. ; Diagnosis. ; Bioethics.
    Description / Table of Contents: Genetic Testing, Some Themes and Some Basics -- Autosomal Dominant Inheriance and Huntington Disease -- Autosomal Recessive Inheritance and Cystic Fibrosis -- X-linked Inheritance: a Question of Gender -- Genetics Testing in Cancer -- DNA Testing, Genes and Identity -- Out of Sequence: Genome-Scale Testing -- DNA Testing: Pulling the Strands Together.
    Abstract: Over the last decade, technical advances have allowed genomic testing which provides a great opportunity for diagnosis but also an increased chance of uncertain or unexpected findings. This book addresses many of the questions that arise in this context and summarizes the essential concepts in diagnostic genetic testing in an easy-to-read manner. It also covers some broad context for the practical and ethical implications of examining human DNA sequences. The book starts with a general introduction to the field, providing enough background to allow readers without any previous education in genetics to comprehend the material in the subsequent chapters. The main part explores differing aspects of human genetics and the wider implications of testing in these areas. The author covers not only single gene inheritance, but also genetic testing of cancers and how testing benefits the patients. Special emphasis is also given to the questions of genetics and identity. The concluding part then draws the main themes together and summarises the wider significance of genetics. It also explores the gap between promises made for the impact of advances in genetics, and the actual benefits to patients. The book is written for everyone interested to learn about the process of genetic testing and the broader implications. Moreover, it is aimed at health professionals with an interest in genetics, at students or scientific trainees looking for an introduction to diagnostic genetics, and at professionals in health policy or health journalism.
    Type of Medium: Online Resource
    Pages: XXII, 131 p. 17 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030855109
    URL: https://doi.org/10.1007/978-3-030-85510-9
    DOI: 10.1007/978-3-030-85510-9
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 22
    Online Resource
    Online Resource
    Fundamentals of RNA Structure and Function (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Biomaterials. ; Nucleic acids. ; Biotechnology. ; Medical Genetics. ; Nucleic Acid. ; Biotechnology.
    Description / Table of Contents: 1. RNA-Composition and Base Pairing -- 2. Architecture of RNA -- 3. Small Catalytic RNA -- 4. The Spliceosome: A Large Catalytic RNA -- 5. A Genomic Perspective on RNA -- 6. The mRNA and the New Vaccines -- 7. Riboswitches: Sensors and Regulators -- 8. Small Non-Coding RNA, miRNA in Gene Regulation -- 9. CRISPR-Cas Systems, The science and ethics of gene manipulation -- 10. Transcription.
    Abstract: This highly illustrated textbook provides an essential overview on RNA architecture and function, it offers insights into the RNA basics and also explains novel RNA technologies, such as CRISPR-Cas and their applications. In addition, the mRNA based vaccine technology, which has long been tested, also before the COVID-19 pandemic, is discussed and students receive a basic understanding of this important medical application. The textbook is written by Prof. Grover in collaboration with her students and has an easily accessible style. The book provides a great tool for young researchers and students in biology, biomedical engineering or biochemistry, looking for a compact introduction or refresher work on RNA, including the newest findings and technologies. It is an ideal starter to learn about several RNA specific topics and to research them further.
    Type of Medium: Online Resource
    Pages: XVI, 246 p. 108 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030902148
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-90214-8
    DOI: 10.1007/978-3-030-90214-8
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 23
    Online Resource
    Online Resource
    The Chemical Biology of Long Noncoding RNAs (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Biomaterials. ; Nucleic acids. ; Biotechnology. ; Medical Genetics. ; Nucleic Acid. ; Biotechnology.
    Description / Table of Contents: Long Non-Coding RNAs Diversity in Form and Function - from Microbes to Humans -- Evolving Roles of Long Noncoding RNAs -- Biogenesis and Function of the Noncoding Isoform-Type LncRNAs -- Long Non-Coding RNAs in a Single Cell Type: Function and Subcellular Localization -- Long Non-Coding RNAs as Scaffolds for Multiprotein Signalling Complexes -- Landscape of Long Non-Coding RNA Genes, Pseudogenes and Protein Genes in Segmental Duplications in the Critical Human Chromosomal Region 22q11.2 -- Long Non-Coding RNAs and Cancer Cells’ Drug Resistance: an Unexpected Connection -- Long Noncoding RNAs as Drivers of Acquired Chemoresistance in Hepatocellular Carcinoma -- Single Cell Analysis May Shed new Lights on the Role of LncRNAs in Chemo-Resistance in Gastrointestinal Cancers -- LncRNAs in the Development, Progression, and Therapy Resistance of Hormone-Dependent Cancer -- Tumorigenesis-Related Long Non-Coding RNAs and their Targeting as Therapeutic Approach in Cancer -- Long Non-Coding RNAs in Non-Small Cell Lung Cancer: State of the Art -- Long Non-Coding RNAs in Cardiovascular Diseases -- Long Non-Coding RNAs in Cardiovascular Development and Diseases.-Long Noncoding RNAs as Players in Breast Tumorigenesis -- Drosophila Models to Study Long Non-Coding RNAs Related to Neurological Disorders -- Regulatory Roles of Long Non-Coding RNAs in Skeletal Muscle Differentiation, Regeneration, and Disorders -- Long Noncoding RNAs in Substance Use Disorders -- The Multifaceted Roles of LncRNAs in Diabetic Complications: a Promising, yet Perplexing Paradigm -- Long Non-Coding RNAs in Diabetes and β-cell Regulation.
    Abstract: This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.
    Type of Medium: Online Resource
    Pages: X, 545 p. 49 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030447434
    Series Statement: RNA Technologies, 11
    URL: https://doi.org/10.1007/978-3-030-44743-4
    DOI: 10.1007/978-3-030-44743-4
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 24
    Online Resource
    Online Resource
    HSF1 and Molecular Chaperones in Biology and Cancer (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Cancer. ; Medicine Research. ; Biology Research. ; Proteins . ; Proteins. ; Medical Genetics. ; Cancer Biology. ; Biomedical Research. ; Protein Biochemistry. ; Proteins.
    Description / Table of Contents: Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks – redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.
    Abstract: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 182 p. 31 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030402044
    Series Statement: Advances in Experimental Medicine and Biology, 1243
    URL: https://doi.org/10.1007/978-3-030-40204-4
    DOI: 10.1007/978-3-030-40204-4
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 25
    Online Resource
    Online Resource
    Mechanisms of Genome Protection and Repair (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Cytology. ; Biochemistry. ; Medicine Research. ; Biology Research. ; Cancer. ; Medical Genetics. ; Cell Biology. ; Biochemistry. ; Biomedical Research. ; Cancer Biology.
    Description / Table of Contents: Preface -- Kinetic Milestones of Damage Recognition by DNA Glycosylases of the Helix–Hairpin–Helix Structural Superfamily -- Protein Engineering of DNA-Dependent Enzymes -- A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis -- Impact of PARP1, PARP2 and PARP3 on the Base Excision Repair of Nucleosomal DNA -- Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling -- DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance -- Mystery of Expansion: DNA Metabolism and Unstable Repeats -- The Detection of 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine in Circulating Cell-Free DNA: A Step Towards Longitudinal Monitoring of Health -- Biotransformation and Toxicities of Aristolochic Acids -- Mechanisms of Sugar Beet Response to Biotic and Abiotic Stresses -- Studying ALS: Current Approaches, Effect on Potential Treatment Strategy.
    Abstract: This volume is about DNA damage and repair. It covers recent advances in several important research areas of this rapidly expanding field, and does so at several levels, from individual molecules to organisms. The topics include mechanisms of damage recognition by DNA repair enzymes, chromatin response to DNA damage, special ways of mutagenesis, biomarkers of genotoxicity, and the integrated organism response to genotoxic and other kinds of stress. The book starts with two chapters about structural and mechanistic features of protein–DNA interactions that ensure fast and reliable discrimination between targets – be it DNA modifications or specific sequences – and non-targets. Examples of particular proteins and their function in repair regulation, translesion synthesis and chromatin remodeling are discussed in the following three chapters. Next, more attention is given to the mutagenic consequences of failed or aberrant DNA repair, particularly in mitochondria and in runs of trinucleotide repeats. Moving to a human health-oriented view, the book presents data on two kinds of lesions, the widely found 8-oxoguanine and the dietary genotoxic adducts with aristolochic acids, as biomarkers of general oxidative stress and specific exposure, respectively. Two final chapters are devoted to the interplay of multiple factors, including genotoxic stress, in the complex phenotypes in humans (amyotrophic lateral sclerosis ) and plants (abiotic stress response). This volume will be of significant interest for scientists working in the field of DNA repair as well as for the general biochemistry and molecular biology audience.
    Type of Medium: Online Resource
    Pages: XVI, 220 p. 30 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030412838
    Series Statement: Advances in Experimental Medicine and Biology, 1241
    URL: https://doi.org/10.1007/978-3-030-41283-8
    DOI: 10.1007/978-3-030-41283-8
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 26
    Online Resource
    Online Resource
    Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Biology Technique. ; Genetics. ; Medical Genetics. ; Experimental Organisms. ; Genetics and Genomics.
    Description / Table of Contents: Early eye development: Specification and Determination -- Generation of third dimension: Axial patterning in the developing Drosophila eye -- Catching the Next Wave: Patterning of the Drosophila eye by the Morphogenetic Furrow -- Ghost in the Machine- the Peripodail Epithelium -- Cell Polarity in Drosophila Retina -- Negative regulation for neural patterning in the Drosophila eye -- Adhesion and the cytoskeleton in the Drosophila pupaleye -- Drosophila eye as a model to study regulation of growth control: The discovery of size control pathways -- Drosophila cancer modeling using the eye imaginal discs -- Recent contributions of the Drosophila eye to unraveling the basis of neurodegeneration -- Genetic regulation of early eye development in non-dipteran insects -- Eyes for an eye: A comparative account on compound eye of Drosophila melanogaster with vertebrate eye -- Index.
    Abstract: Drosophila melanogaster (fruit fly) is a highly versatile model with a genetic legacy of more than a century. It provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases. One of the most important questions in biology is how a multi-cellular organism develops from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question and has led to other questions, such as the role of various genetic and cell biological pathways in regulating the process of pattern formation and growth during organogenesis. The Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This updated second edition covers current progress in the study of molecular genetic mechanisms of pattern formation, mutations in axial patterning, genetic regulation of growth, and more using the Drosophila eye as a model.
    Type of Medium: Online Resource
    Pages: XIV, 368 p. 81 illus., 73 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030422462
    URL: https://doi.org/10.1007/978-3-030-42246-2
    DOI: 10.1007/978-3-030-42246-2
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 27
    Online Resource
    Online Resource
    A Handbook of Gene and Cell Therapy (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Molecular genetics. ; Genetics. ; Medical Genetics. ; Clinical Genetics. ; Molecular Genetics. ; Genetics and Genomics.
    Description / Table of Contents: 1. Gene and Cell therapy overview -- 2. Gene and Cell therapy history -- 3. Delivery systems for gene therapy -- 4. Stem-cells and tissue regeneration theories -- 5. Gene therapy strategies -- 6. Gene and cell therapy applications -- 7. Gene therapy clinical trials -- 8. Research in gene therapy: celllular and animal models -- 9. Future challenges in gene and cell therapy.
    Abstract: This is a reference handbook for young researchers exploring gene and cell therapy. Gene therapy could be defined as a set of strategies modifying gene expression or correcting mutant/defective genes through the administration of DNA (or RNA) to cells, in order to treat disease. Important advances like the discovery of RNA interference, the completion of the Human Genome project or the development of induced pluripotent stem cells (iPSc) and the basics of gene therapy are covered. This is a great book for students, teachers, biomedical researchers delving into gene/cell therapy or researchers borrowing skills from this scientific field.
    Type of Medium: Online Resource
    Pages: XI, 188 p. 67 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030413330
    URL: https://doi.org/10.1007/978-3-030-41333-0
    DOI: 10.1007/978-3-030-41333-0
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 28
    Online Resource
    Online Resource
    Biotechnologies for Gene Therapy : RNA, CRISPR, Nanobots, and Preclinical Applications (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Biomedical engineering. ; Biotechnology. ; Pharmaceutical chemistry. ; Medical Genetics. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Pharmaceutics.
    Description / Table of Contents: 1. Therapeutic potential of microRNAs and their nanoparticle-based delivery in the treatment of liver fibrosis -- 2. MicroRNA as a versatile regulator of Wnt signaling pathway in colorectal cancer -- 3. Small Activating RNA Therapy for Angiogenesis -- 4. Muscular dystrophy therapy using viral vector-based CRISPR/Cas -- 5. CRISPR-Cas based gene therapy to target viral infections -- 6. CRISPR targeting the integrated HTLV-1 virus -- 7. Retroviral vectors for gene therapy of monogenic diseases -- 8. DNA Origami Nanodevices for Therapeutic Delivery Applications.
    Abstract: The purpose of this book is to highlight some of latest developments and applications of CRISPR, RNA, and DNA to treat diseases ranging from cancers to cardiovascular and degenerative disorders. It also features innovations of the delivery methods for nucleic acids ranging from nanodevices made from DNA and pseudo amino acids to viral vectors. This is an ideal book for academics, clinicians, and students interested in gene therapy.
    Type of Medium: Online Resource
    Pages: IX, 203 p. 26 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030933333
    URL: https://doi.org/10.1007/978-3-030-93333-3
    DOI: 10.1007/978-3-030-93333-3
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 29
    Online Resource
    Online Resource
    Human Interphase Chromosomes : Biomedical Aspects (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Molecular genetics. ; Cytology. ; Medical Genetics. ; Molecular Genetics. ; Cell Biology.
    Description / Table of Contents: Human Interphase Cytogenomics -- Eukaryotic genome in three dimensions -- Analysis of cell and nucleus genome by Next-Generation Sequencing -- Interphase Chromosomes of the Human Brain -- Senescence and the Genome -- Unclassified Chromosome Abnormalities and Genome Behavior in Interphase -- 21st century FISH: focus on interphase chromosomes -- Chromosome architecture studied by high resolution FISH-banding in three dimensionally preserved human interphase nuclei -- Chromosome-centric Look at the Genome -- Index.
    Abstract: This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the processing and inheritance of genetic information within and between species. Accordingly, post-genomic bioscience appeals to basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation opens new horizons for basic and applied bioscience Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in diagnostic and research practices to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This second edition serves as a source of updated valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.
    Type of Medium: Online Resource
    Pages: XII, 178 p. 39 illus., 34 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030625320
    URL: https://doi.org/10.1007/978-3-030-62532-0
    DOI: 10.1007/978-3-030-62532-0
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 30
    Online Resource
    Online Resource
    Single Nucleotide Polymorphisms : Human Variation and a Coming Revolution in Biology and Medicine (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical genetics. ; Cytology. ; Bioinformatics. ; Medical Genetics. ; Cell Biology. ; Bioinformatics.
    Description / Table of Contents: SECTION I -- Chapter 1: Evolutionary Forces that Generate SNPs -- Chapter 2: Conserved SNPs: Providing Answers to Fundamental Questions in Human Biology -- Chapter 3: SNPs Classification and Terminology -- SECTION II -- Chapter 4: SNPs Ability to Influence Disease Risk -- Chapter 5: GWAS to Identify SNPs Associated with Common Diseases and Individual Risk -- SECTION III -- Chapter 6: A Case Study of Molecular Mechanisms by Which Non-Synonymous SNPs Alter Protein Structure and Function -- Chapter 7: A Case Study of Molecular Mechanisms by Which Synonymous SNPs Alter Protein Structure and Function -- SECTION IV -- Chapter 8: Using Genome-Wide Studies to Study Synonymous Codons -- Chapter 9: Bioinformatics Tools for Identification of SNPs -- Chapter 10: Bionformatic Tools for Predicting SNPs Effects on Gene Function and Phenotype -- Chapter 11: New Biophysical Techniques for Single mRNA Molecule Measurements -- Chapter 12: Emerging Mechanisms by Which Synonymous Mutations Affect Protein Folding, Protein Function and Physiological Changes -- SECTION V -- Chapter 13: SNPs and Personalized Medicine -- Chapter 14: Distribution of SNPs Associated with Personality Traits -- Chapter 15: Condon Optimization.
    Abstract: This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research. As SNP technologies have evolved from labor intensive, expensive, time-consuming processes to relatively inexpensive methods, SNP discovery has exploded. In terms of human biology, this research, particularly since the completion of the Human Genome Project, has provided a detailed understanding of evolutionary forces that have generated SNPs. It also has shown how SNPs shape human variation. The ability to inexpensively generate and analyze vast amounts of genetic data is poised to transform our understanding of human evolution and biology. “Single Nucleotide Polymorphisms” covers a broad survey of SNPs and their classification into synonymous and non-synonymous; the role of SNPs in human disease; case studies providing specific examples of synonymous and non-synonymous SNPs associated with human diseases or affecting therapeutic interventions; mechanisms by which synonymous mutations affect protein levels or protein folding which affect human physiology and response to therapy; and the role of SNPs in personalized medicine. Understanding what SNPs are, how they have been shaped is necessary for an increasingly expanding audience. This research will revolutionize the future of medicine. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. SNPs Ability to Influence Disease Risk: Breaking the Silence on Synonymous Mutations in Cancer" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVIII, 234 p. 23 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031056161
    URL: https://doi.org/10.1007/978-3-031-05616-1
    DOI: 10.1007/978-3-031-05616-1
    DDC: 616.042
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
  • 31
    Online Resource
    Online Resource
    Cancer Stem Cell Markers and Related Network Pathways (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Medical microbiology. ; Biomedical Research. ; Biomedical Research. ; Medical Genetics. ; Medical Microbiology.
    Description / Table of Contents: 1. Epithelial-mesenchymal transition and cancer stem cells -- 2. The transcription factors Zeb1 and Snail induce cell malignancy and can-cer stem cell phenotype in prostate cells, increasing androgen synthesis ca-pacity and therapy resistance -- 3. ERBB signaling pathway in cancer stem cells -- 4. Functional and molecular characters of cancer stem cells through devel-opment to establishment -- 5. Microenvironment in cancer stem cells -- 6. Cancer stem cells contribute to drug resistance in multiple different ways -- 7. Abnormal glycosylation in cancer cells and cancer stem cells as a thera-peutic target.
    Abstract: This book entitled “Cancer Stem Cell Markers and Related Network Path-ways” is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype. This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways. The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters. The topic of this book is particularly relevant to research in the field of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.
    Type of Medium: Online Resource
    Pages: XIV, 156 p. 23 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031129742
    Series Statement: Advances in Experimental Medicine and Biology, 1393
    URL: https://doi.org/10.1007/978-3-031-12974-2
    DOI: 10.1007/978-3-031-12974-2
    DDC: 610.72
    Language: English
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    E-BOOKS (AWI ONLY)
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...