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  • Books  (20)
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  • Virology.  (20)
  • Cham :Springer International Publishing :  (20)
  • Berlin ; Heidelberg : Springer
  • Ottawa : Geological Survey of Canada
  • Wabern : Federal Office of Topography, Swiss Geological Survey
  • 579.2  (16)
  • 615  (4)
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  • Books  (20)
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  • 1
    Online Resource
    Online Resource
    History of Arbovirology: Memories from the Field : Volume I: Personal Reflections (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Medicine Research. ; Biology Research. ; Life sciences. ; Virology. ; Biomedical Research. ; Life Sciences.
    Description / Table of Contents: 1. The Quest for Excellence and the Challenge of Gender Equality in Arbovirology: A Celebration of Women’s Contributions to the Field -- 2. Serendipity and Arboviruses -- 3. The Tapestry of Life: Weaving an Arbovirologist -- 4. Arbovirus and Viral Hemorrhagic Fevers Research Inception in Central and West Africa -- 5. From Bwamba to the Present: The Changing Forest of Arbovirology -- 6. Fighting Dengue, Chikungunya and Japanese Encephalitis -- 7. Chronicles of Hantaviruses: Foundations of Epidemiology and Ecology -- 8. Yellow Fever and Other Viruses in West Africa -- 9. The “Golden Age” of Arbovirology, 1950-1969 -- 10. Twenty-Seven Years of Field Studies on Dengue and Aedes Aegypti in Latin America -- 11. 50 Years of Medical Entomology: Miscellaneous Interesting Findings -- 12. Remembrances of Virology Past -- 13. An Overview of Arbovirology in São Paulo State, Southeastern Brazil: Highlighting the Virus Research Center in Ribeirão Preto City -- 14. An Unplanned Career in Arbovirology.
    Abstract: These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.
    Type of Medium: Online Resource
    Pages: XX, 542 p. 258 illus., 200 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219993
    URL: https://doi.org/10.1007/978-3-031-21999-3
    DOI: 10.1007/978-3-031-21999-3
    DDC: 579.2
    Language: English
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  • 2
    Online Resource
    Online Resource
    Virus Infected Cells (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Clinical biochemistry. ; Diseases Causes and theories of causation. ; Microbiology. ; Molecular biology. ; Biology Technique. ; Virology. ; Medical Biochemistry. ; Pathogenesis. ; Microbiology. ; Molecular Biology. ; Biological Techniques.
    Description / Table of Contents: Part 1: General / Technical Aspects -- Chapter 1: In Situ Imaging Of Virus Infected Cells By Cryo-Electron Tomography: An Overview -- Chapter 2: Approaches To Evaluating Necroptosis In Virus Infected Cells -- Chapter 3: Apoptosis And Phagocytosis As Antiviral Mechanisms -- Chapter 4: The Art Of Viral Membrane Fusion And Penetration -- Chapter 5: Single Particle Tracking Of Virus Entry In Live Cells -- Chapter 6: Correlative Cryo-Imaging Using Soft X-Ray Tomography For The Study Of Virus Biology In Cells And Tissues -- Chapter 7: The Virus-Induced Cytopathic Effect -- Part 2: Specific Viruses -- Chapter 8: Human Papilloma Virus-Infected Cells -- Chapter 9: Defining The Assembleome Of The Respiratory Syncytial Virus -- Chapter 10: Japanese Encephalitis Virus Infected Cells -- Chapter 11: African Swine Fever Virus Host-Pathogen Interactions -- Chapter 12: Coronavirus And The Cytoskeleton Of Virus-Infected Cells -- Chapter 13: Viral Rna Is A Hub For Critical Host-Virus Interactions -- Chapter 14: Influenza A Virus: Cellular Entry -- Chapter 15: Human Endogenous Retroviruses In Diseases -- Chapter 16: Cholesterol And M2 Rendezvous In Budding And Scission Of Influenza A Virus.
    Abstract: Virus-infected Cells is a comprehensive and technical exploration of the intricate interactions between viruses and host cells. This book delves into the molecular and cellular aspects of viral infections, providing a wealth of knowledge about various viruses and their effects on cellular mechanisms. The first part of the book covers general/technical aspects, introducing the reader to the field of virology and providing an overview of the techniques used to study virus-infected cells. It covers topics such as the visualisation of virus-infected cells by cryo-electron tomography and the assessment of necroptosis, a type of programmed cell death, in virus-infected cells. In addition, the book explores the role of apoptosis and phagocytosis as antiviral mechanisms, as well as the intricate process of viral membrane fusion and penetration. It also discusses the tracking of viral entry into living cells and the use of correlative cryo-imaging to study the biology of viruses in cells and tissues. Finally, the book examines the cytopathic effect induced by viruses, shedding light on the damage caused to infected cells. The second section of the book explores specific viruses and their interactions with host cells. Each chapter focuses on a specific virus and provides an in-depth look at its behaviour within infected cells. The book covers a wide range of viruses, including human papillomavirus, respiratory syncytial virus, Japanese encephalitis virus, African swine fever virus, coronavirus, influenza A virus and human endogenous retroviruses. Each chapter examines unique aspects of virus-host interactions, such as viral assembly, impact on the cytoskeleton, critical host-virus interactions mediated by viral RNA, mechanisms of cell entry, and the involvement of cholesterol in virus budding and scission. This volume in the Subcellular Biochemistry series is a valuable resource for researchers, virologists and students interested in understanding the complex dynamics between viruses and the cells they infect. With its detailed exploration of general and specific aspects of virus-host interactions, this book provides a comprehensive understanding of the molecular and cellular mechanisms involved in viral infections.
    Type of Medium: Online Resource
    Pages: VIII, 459 p. 70 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031400865
    Series Statement: Subcellular Biochemistry, 106
    URL: https://doi.org/10.1007/978-3-031-40086-5
    DOI: 10.1007/978-3-031-40086-5
    DDC: 579.2
    Language: English
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  • 3
    Online Resource
    Online Resource
    Varicella-zoster Virus : Genetics, Pathogenesis and Immunity (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Immunology. ; Human physiology. ; Vaccines Biotechnology. ; Biomaterials. ; Virology. ; Immunology. ; Human Physiology. ; Biomaterials-Vaccines.
    Description / Table of Contents: Varicella-zoster Virus - Genetics, Molecular Evolution, and Recombination -- The structures and functions of VZV glycoproteins -- Modulation of apoptosis and cell death pathways by Varicella zoster virus -- Modulation of host cell signaling pathways by varicella-zoster virus -- Modulation of MHC and MHC-like molecules by Varicella Zoster Virus -- Varicella Zoster Virus Neuronal Persistence and Reactivation modeled in-vitro -- Humanized Severe Combined Immunodeficient (SCID) Mouse Models for Varicella-Zoster Virus Pathogenesis -- Simian Varicella Virus: Molecular Virology and mechanisms of pathogenesis -- A guide to preclinical models of zoster-associated pain and postherpetic neuralgia -- Immune Responses to Varicella-Zoster Virus Vaccines -- Common features between stroke following varicella in children and stroke following herpes zoster in adults.
    Abstract: This edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus. The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases. Chapter "Common features between stroke following varicella in children and stroke following herpes zoster in adults" is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com.
    Type of Medium: Online Resource
    Pages: VIII, 272 p. 39 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031153051
    Series Statement: Current Topics in Microbiology and Immunology, 438
    URL: https://doi.org/10.1007/978-3-031-15305-1
    DOI: 10.1007/978-3-031-15305-1
    DDC: 579.2
    Language: English
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  • 4
    Online Resource
    Online Resource
    Bioprocess and Analytics Development for Virus-based Advanced Therapeutics and Medicinal Products (ATMPs) (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Biomedical engineering. ; Biotechnology. ; Microbial genetics. ; Analytical biochemistry. ; Therapeutics. ; Virology. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Microbial Genetics. ; Analytical Biochemistry. ; Therapeutics.
    Description / Table of Contents: Chapter 1: Bioprocessing and analytical development for virus-based therapeutics -- Chapter 2: Viral Vector Upstream Processing and Clarification -- Chapter 3: Upstream processing of viral therapeutics: From host cell expansion to virus production -- Chapter 4: Leveraging virus biology and host genetic conflicts for cell line development and engineering for virus-based therapeutics -- Chapter 5: Overview of Current Downstream Processing for Modern Viral Vectors -- Chapter 6: Filtration Principles and Techniques for Bioprocessing of Viral Vector–Based Therapeutics -- Chapter 7: Chromatographic purification of viruses: State of the art and current trends -- Chapter 8: Purifying Viral Vectors - A Review of Chromatography Solutions -- Chapter 9: Particle analytics - Comparative approaches for analysis of viral vectors -- Chapter 10: Phase-Appropriate Potency Assay Development for AAV-based Gene Therapy Products -- Chapter 11: Quantification of virus infectivity – the key assay for the development of viral therapeutics -- Chapter 12: Product-related impurities in therapeutic virus bioprocessing -- Chapter 13: Process Analytical Technologies (PAT) and Quality by Design (QbD) for bioprocessing of virus-based therapeutics -- Chapter 14: Methods and practical considerations in imaging viral therapeutics -- Chapter 15: Application of NMR Spectroscopy in Viral Assembly Characterization -- Chapter 16: Improved Production Strategies for Oncolytic Measles Viruses as a Therapeutic Cancer Treatment -- Chapter 17: Recent Advancements and Challenges in Recombinant Expression for Commercial Production of Virus Like Particles (VLPs) -- Chapter 18: Oncolytic viruses and viral gene therapy vectors: Principles of safety.
    Abstract: This book reviews the knowledge, methods and available techniques in the rapidly advancing field of virus based vaccines and gene therapeutics. It also highlights new innovative tools and interdisciplinary techniques for bioprocess development and analytics of viruses and viral vectors. As such, it provides a timely and highly relevant resource, since current advances in pharmaceutical research have seen the rise of vaccines and advanced therapeutics and medicinal products (ATMPs), that rely on the power of viruses. However, developing bioprocesses and analytics required to create this often called “magic bullet” (i.e. gene therapy) remains an extremely challenging and costly task. This book offers strategies for overcoming hurdles and difficulties within in all the necessary steps of viral vector development - from scalability to purification methods and quality control. The book is intended for researchers working in academia or industry, as well as graduate students pursuing a career in virology.
    Type of Medium: Online Resource
    Pages: XVI, 442 p. 84 illus., 62 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031284892
    URL: https://doi.org/10.1007/978-3-031-28489-2
    DOI: 10.1007/978-3-031-28489-2
    DDC: 579.2
    Language: English
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  • 5
    Online Resource
    Online Resource
    Viral Fitness and Evolution : Population Dynamics and Adaptive Mechanisms (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Evolution (Biology). ; Evolutionary genetics. ; Virology. ; Evolutionary Biology. ; Evolutionary Genetics.
    Description / Table of Contents: Theoretical analysis of the evolution of viral populations in sequence space, and empirical fitness landscapes -- Self-organized maps to derive fitness landscapes from deep sequencing data -- Mutations to overcome viral resistance in plants -- The role of recombination in the generation of new begomovirus phenotypes -- Plant virus adaptation to new hosts -- Viral fitness, host interactions, and resistance to antiviral agents -- Viral fitness and evolution of hepatitis C virus -- Population dynamics and fitness variations of hemorrhagic RNA viruses -- Coronavirus genome sequences, variation, and disease implications -- Epilogue: viral populations from a theoretical and experimental perspective.
    Abstract: This book unifies general concepts of plant and animal virus evolution and covers a broad range of topics related to theoretical and experimental aspects of virus population dynamics and viral fitness. Timely topics such as viral mechanisms to cope with antiviral agents, the adaptability of the virus to new hosts, emergence of new viral phenotypes, and the connections between short- and long-term virus evolution are included. By comparing plant and animal viruses, universal mechanisms responsible for fitness variations, viral emergence and disease mechanisms are explored. Although emphasis is put on specific plant and human viral pathogens, relevant similarities and differences to other viruses are highlighted. Additionally, readers will learn more about the adaptability of coronaviruses, including the recently emerged SARS-CoV-2, the causative agent of the COVID-19 pandemic. The book is aimed at students and scientists interested in basic and applied aspects of plant and animal virus population dynamics and evolution.
    Type of Medium: Online Resource
    Pages: X, 344 p. 80 illus., 74 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031156403
    Series Statement: Current Topics in Microbiology and Immunology, 439
    URL: https://doi.org/10.1007/978-3-031-15640-3
    DOI: 10.1007/978-3-031-15640-3
    DDC: 579.2
    Language: English
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  • 6
    Online Resource
    Online Resource
    Lassa Fever: Epidemiology, Immunology, Diagnostics, and Therapeutics (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Medical microbiology. ; Internal medicine. ; Tropical medicine. ; Virology. ; Medical Microbiology. ; Internal Medicine. ; Tropical Medicine.
    Description / Table of Contents: 50 years of Lassa fever research -- Lassa Virus Genetics -- Ecology of Lassa virus -- Epidemiology of Lassa Fever -- Lassa virus countermeasures -- Lassa virus structural biology and replication -- Lassa Fever Natural History and Clinical Management.
    Abstract: This volume provides a comprehensive and up-to-date overview of the various aspects of Lassa virus (LASV), the causative agent of Lassa fever, a frequently fatal zoonotic disease endemic to West Africa. Compiled by world-leading experts in the field, this book provides an introduction to the 50-year history of Lassa fever research, the genetic diversity of LASV, and its geographic distribution. Subsequent chapters focus on the ecology and epidemiology of LASV, discussing in-depth the interactions of the virus with its hosts - multimammate mice and other rodents - and the interactions between these animal reservoirs and humans. The book also details the many advances in understanding the structural biology and replication of LASV, including new insights into the structure and function of its proteins. These advances in the basic understanding of LASV biology have enabled the development of LASV countermeasures, including sensitive and specific diagnostic assays. Promising drug candidates, including monoclonal antibodies, and vaccines are also discussed. A final and essential chapter addresses current and future clinical practice for clinical management of Lassa fever. This volume is intended for researchers and clinicians in the fields of virology, epidemiology, and microbiology.
    Type of Medium: Online Resource
    Pages: IX, 192 p. 32 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031358074
    Series Statement: Current Topics in Microbiology and Immunology, 440
    URL: https://doi.org/10.1007/978-3-031-35807-4
    DOI: 10.1007/978-3-031-35807-4
    DDC: 579.2
    Language: English
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  • 7
    Online Resource
    Online Resource
    Challenges and Opportunities of mRNA Vaccines Against SARS-CoV-2 : A Multidisciplinary Perspective (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Medical microbiology. ; Biotechnology. ; Virology. ; Medical Microbiology. ; Biotechnology.
    Description / Table of Contents: Chapter 1: Introduction -- Part I: Scientifi Underpinnings, early expectations, and emerging challenges from the global inoculation experience -- Chapter 2: Appraisal of Some of the Key Postulates Underlying mRNA Vaccines -- Chapter 3: Relevance for mRNA vaccine safety -- Chapter 4: From Challenges to Opportunities and Open Questions -- Chapter 5: The challenge of evaluating vaccine safety and effectiveness -- Chapter 6: Safeguarding against the analog of antimicrobial-resistance development -- Chapter 7: Scales, pseudoscales, the human factor, and a way forward -- Part II: A deeper dive into mRNA vaccine safety and security, and developments until Delta -- Chapter 8: mRNA Vaccine safety and efficacy - official criteria when AEs are caused by the injection -- Chapter 9: mRNA Covid-19 vaccines best reflect effective pharmaceuticals - basic considerations and LNPs -- Chapter 10: mRNA Covid-19 pharmaceuticals and the spike antigen -- Chapter 11: Other facets of SARS-CoV-2 immunity, the risk of immune tolerance and T cell exhaustion -- Part III: The Omicron variants -- Chapter 12: Omicron -- Chapter 13: Conclusion.
    Abstract: This book offers an analytical look at the much debated risks and benefits of the newly developed COVID-19 mRNA-vaccines. As such, it is one of the first books to give a comprehensive overview of mRNA vaccines against COVID-19 and the only one that addresses this topic from a broad multidisciplinary background. It brings together insights from various underlying disciplines on the challenges of developing and evaluating the most suitable vaccines for mass vaccination programs enrolled throughout the world - focusing on safety and efficacy. This book should not be missing on the shelf of any biomedical researcher, epidemiologist, public health professional or clinical researcher interested in SARS-CoV2 or virology and vaccine development in general. .
    Type of Medium: Online Resource
    Pages: XXXII, 439 p. 61 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031189036
    URL: https://doi.org/10.1007/978-3-031-18903-6
    DOI: 10.1007/978-3-031-18903-6
    DDC: 579.2
    Language: English
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  • 8
    Online Resource
    Online Resource
    Physical Virology : From the State-of-the-Art Research to the Future of Applied Virology (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Biophysics. ; Biomolecules. ; Physical biochemistry. ; Macromolecules. ; Biomechanics. ; Biology Technique. ; Genetic engineering. ; Virology. ; Biophysics. ; Structural Biology. ; Biomechanics. ; Molecular Biophysics. ; Gene Delivery.
    Description / Table of Contents: Viral RNA as a Branched Polymer -- RNA Multiscale Simulations as an Interplay of Electrostatic, Mechanical Properties, and Structures Inside Viruses -- Establishing the Length Limit of RNA Packaged In Vitro by Spherical Virus-Like Particles -- The Multiple Regulatory Roles of Single-stranded RNA Viral Genomes in Virion Formation and Infection -- Creating Artificial Viruses using Self-assembled Proteins and Polypeptides -- Construction of Higher-order VLP-based Materials and Their Effect on Diffusion and Partitioning -- Assembly of Coronaviruses and CoV-like-particles -- Norovirus – A Viral Capsid in Perpetual Flux -- Structural Alterations in Non-enveloped Viruses During Disassembly -- Physical Virology with Atomic Force and Fluorescence Microscopies: Stability, Disassembly and Genome Release -- Virus Mechanics: A Structure-Based Biological Perspective -- Cryo-electron Microscopy and Cryo-electron Tomography of Viruses -- Bacteriophage Lambda as a Nano Theranostic Platform -- Therapeutic Interfering Particles (tips): Escape-Resistant Antiviral Against SARS-CoV-2.
    Abstract: This book highlights key findings generated during the past years from the main disciplines that constitute Physical Virology, from theoretical physics and simulations to material sciences and vaccines development to structural biology. Each chapter is written by world-class scientists from these areas and is a comprehensive review of where this field stands, as well as the future of Physical Virology. The diversity in the formal training of these scientists results in solving common problems using very distinct approaches, which can produce surprising findings. The multi- and interdisciplinary nature of this field has created a remarkable community that aims at understanding how viruses work and how they can be used in material sciences, chemistry, and biomedicine. Furthermore, the development of Physical Virology has resulted in technological advances that have shaped other fields; for example, it would be impossible to think about the development of Cryo-EM to solve the structure of complex viruses with atomic resolution without the contribution of scientists that created the field of Physical Virology. In the past decade, there has been a great success in the generation of viral systems that can encapsulate drugs, non-viral genetic material, or nanoparticles, as well as in the chemical and genetical modification of virions. Without any doubt in the immediate future, some of these technologies will jump from the bench to the market, creating a revolution in translational and biomedical sciences. The book provides key perspectives for the field, derived from expert´s opinions.
    Type of Medium: Online Resource
    Pages: VIII, 340 p. 99 illus., 89 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031368158
    Series Statement: Springer Series in Biophysics, 24
    URL: https://doi.org/10.1007/978-3-031-36815-8
    DOI: 10.1007/978-3-031-36815-8
    DDC: 579.2
    Language: English
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  • 9
    Online Resource
    Online Resource
    Bacteriophages as Drivers of Evolution : An Evolutionary Ecological Perspective (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Microbial ecology. ; Virology. ; Microbial Ecology.
    Description / Table of Contents: Chapter 1. Bacteriophages, a Brief Introduction -- Chapter 2. A Closer Overview of Phage Infections -- Chapter 3.Evolutionary Biology Basics -- Chapter 4. Brief Introduction to Phage Ecology -- Chapter 5.Bacterial Mutation Associated with Phages: Insertions -- Chapter 6. Bacterial Mutation Associated with Phages: Deletions -- Chapter 7. Genetic Drift and Phages -- Chapter 8. Phages and Asexual Bacterial Populations -- Chapter 9.Phage Impact on Non-Random Mating Among Bacteria -- Chapter 10. Genetic Migration and Phages -- Chapter 11. Bacterial Reproductive Isolation and Its Violation by Phages -- Chapter 12. Phage-Provided Environmental DNA and Superspreading -- Chapter 13. Transduction of Large Amounts of DNA -- Chapter 14. Phage Morons -- Chapter 15. Why Lysogenic Conversion? -- Chapter 16. Prophages Preventing Phage Superinfection -- Chapter 17. Domestication of Phage Genes -- Chapter 18.Resistance to Phages, Part I: Overview -- Chapter 19. Resistance to Phages, Part II: Bacteria Live! -- Chapter 20.Resistance to Phages, Part III: Bacteria Die..-Chapter 21. Bacterial Mutation to Phage Resistance -- Chapter 22. Pleiotropic Costs of Phage Resistance -- Chapter 23. Concepts of Natural Selection in Light of Phage Exposure -- Chapter 24. Frequency-Dependent Selection in Light of Phage Exposure -- Chapter 25. A Primer on Phage-Bacterium Antagonistic Coevolution.
    Abstract: This monograph emphasizes the many facets of bacterial evolution as impacted by bacterial interactions with phages, as well as, to a lesser degree, the evolutionary impact of phages on other organisms, including other phages. The book starts with a general overview of bacteriophages. Topics discussed in detail include but are not limited to mutagenesis, migration, natural selection and genetic drift as the drivers of evolution as well as an extensive discussion from the author’s unique perspective on phage ecology. .
    Type of Medium: Online Resource
    Pages: XXV, 377 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030943097
    URL: https://doi.org/10.1007/978-3-030-94309-7
    DOI: 10.1007/978-3-030-94309-7
    DDC: 579.2
    Language: English
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  • 10
    Online Resource
    Online Resource
    Viruses: Intimate Invaders (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Medical microbiology. ; Epidemiology. ; Virology. ; Medical Microbiology. ; Epidemiology.
    Description / Table of Contents: 1 The Question of Life -- 2 Families, Forms, and Functions -- 3 Ancient or New – On the Origin of Viruses -- 4 Of Predators and Prey -- 5 Immunity, Immunity, Immunity -- 6 Viruses That Shaped Our World -- 7 SV40 - An Obscure Monkey Virus and the Golden Age of Molecular Biology -- 8 Viral Cancer -- 9 The Viruses Within - How Human Are We? -- 10 Vaccines and the Conquest of Viruses -- 11 New and Emerging Viruses -- 12 Beyond Antibiotics – Are Phages our Allies? -- 13 Viruses in Gene Therapy and Cancer Therapeutics.
    Abstract: This book guides through the fascinating world of viruses and makes readers enjoy science in an accessible way. Virologist and author Professor Van Wilson imparts knowledge about what viruses are, how they work, and how much they impact life on Earth. The book equips the reader with the scientific basics behind virus function and presents the historic milestones of virus research and discovery. Well-known viruses such as HIV or Influenza are tackled alongside novel pathogens like coronavirus SARS-CoV-2. Professor Wilson explores where they come from and how they impact our society. Last but not least the book provides exciting insights into how our immune system reacts to different viruses and how vaccines contribute to conquer pandemics. While scientifically informative, this book makes the field of virology understandable to a lay audience and encourages readers to further thinking. And more importantly, it conveys the wonder, beauty, and mystery of these ubiquitous, microscopic marvels. This book addresses anyone interested in understanding the principles of virology, viral diseases, or the impact of viruses on human societies.
    Type of Medium: Online Resource
    Pages: XXIV, 341 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030854874
    URL: https://doi.org/10.1007/978-3-030-85487-4
    DOI: 10.1007/978-3-030-85487-4
    DDC: 579.2
    Language: English
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  • 11
    Online Resource
    Online Resource
    Clinical, Biological and Molecular Aspects of COVID-19 (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Respiratory organs. ; Physiology. ; Metabolism. ; Virology. ; Respiratory Physiology. ; Metabolism.
    Description / Table of Contents: SARS-CoV-2 (COVID-19): Beginning to Understand a New Virus -- Neurological Complications of the COVID-19 Pandemic: What have we got so Far? -- Endothelial Dysfunction as a Primary Consequence of SARS-CoV-2 Infection -- A Review Study on the Neonatal Outcomes of Pregnant Women with COVID-19 -- Relationship between COVID-19 and Angiotensin-Converting Enzyme 2: A Scoping Review -- Experience in Nutrition Management of Diabetes-affected COVID-19 Patients -- Emerging Technologies for the Treatment of COVID-19 -- Obesity and risk of COVID-19 infection and severity: available evidence and mechanisms -- COVID-19 is an Endothelial Disease: Implications of Nitric Oxide -- Immune Response and Effectiveness of COVID-19 Therapies -- The Novel Coronavirus and Inflammation -- Does SARS-CoV-2 Threaten Male Fertility? -- COVID-19 and Vulnerable Populations in Sub-Saharan Africa: a Review -- Overview of the Haematological Effects of COVID-19 Infection -- The Novel Coronavirus and Haemostatic Abnormalities: Pathophysiology, Clinical Manifestations and Treatment Recommendations -- COVID-19 related laboratory analyte changes and the relationship between SARS-CoV-2 and HIV, TB and HbA1c in South Africa -- The Primary Outcomes, Epidemiological and Clinical Features of Coronavirus Disease-2019 (COVID-19) in Iran -- Acute Respiratory Distress Syndrome and COVID-19: A Scoping Review and Meta-Analysis -- Depression, Anxiety and Stress Among Patients with COVID-19: A Cross-sectional Study -- Survey of Immediate Psychological Distress Levels among Health Care Workers in the COVID-19 Epidemic: A Cross-sectional Study -- Coronavirus (COVID-19)-Associated Psychological Distress Among Medical Students in Iran -- A Survey of Psychological Distress among the Community in the COVID-19 Epidemic: A Cross-Sectional Study -- Gender Susceptibility to COVID-19 Mortality: Androgens as the Usual Suspects? -- Identification, Monitoring and Prediction of Disease Severity in Patients with COVID-19 Pneumonia Based on Chest Computed Tomography Scans: a Retrospective Study -- The Level of Procalcitonin in Severe COVID-19 Patients: A Systematic Review and Meta-analysis -- A Systematic Review of 571 Pregnancies Affected by COVID-19 -- The 2019 Novel Coronavirus Disease in Pregnancy: A Systematic Review -- Acute Kidney Injury and Covid-19: a Scoping Review and Meta-analysis -- Cardiac Injury in COVID-19: A Systematic Review -- A Systematic Review of the Assessment of the Presence of SARS-CoV-2 in Human Semen -- Index.
    Abstract: The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just eight months. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as heart disease, asthma, and diabetes. As the peak begins to slow in many countries, the death rates remain high amidst justified fears of a second wave. A rapid worldwide mobilization has begun to identify effective treatments and develop vaccines. This new volume will increase readers’ understanding of the ongoing COVID-19 pandemic through a series of chapters that address these concerns. Leading experts will discuss the effects of the virus in cases of co-morbidities, new treatment approaches, mental health aspects of the pandemic, and convey the results of survey studies. The book will be an excellent resource for researchers studying virology, metabolic diseases, respiratory disorders, and clinical scientists, physicians, drug companies, and healthcare services and workers.
    Type of Medium: Online Resource
    Pages: XVII, 353 p. 53 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030592615
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1321
    URL: https://doi.org/10.1007/978-3-030-59261-5
    DOI: 10.1007/978-3-030-59261-5
    DDC: 579.2
    Language: English
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    Coronavirus Disease - COVID-19 (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Immunology. ; Epidemiology. ; Virology. ; Immunology. ; Epidemiology.
    Description / Table of Contents: Chapter 1. Introduction on Coronavirus Disease (COVID-19) Pandemic: The Global Challenge (Nima Rezaei, Saboura Ashkevarian, Mahsa Keshavarz Fathi, Sara Hanaei, Zahra Kolahchi, Seyedeh-Sanam Ladi Seyedian, Elham Rayzan, Mojdeh Sarzaeim, Aida Vahed, Kawthar Mohamed, Sarah Momtazmanesh, Negar Moradian, Zahra Rahimi Pirkoohi, Noosha Sameeifar, Mahsa Yousefpour, Sepideh Sargoli, Saina Adiban, Aida Vahed, Niloufar Yazdanpanah, Heliya Ziaei, Amene Saghazadeh) -- Chapter 2. Coronaviruses: What Should We Know About the Characteristics of Viruses? (Wei Ji) -- Chapter 3. Ecology and Evolution of Betacoronaviruses (Eduardo Rodríguez-Román, Adrian J. Gibbs) -- Chapter 4. The Epidemiologic Aspects of COVID-19 Outbreak: Spreading Beyond Expectations (Sara Hanaei, Farnam Mohebi, Maziar Moradi-Lakeh, Parnian Jabbari, Surinder Kumar Mehta, Liudmyla S. Kryvenko, Livio Luongo, Loďc Dupré, Nima Rezaei) -- Chapter 5. The Incubation Period of COVID-19: Current Understanding and Modeling Technique (Char Leung) -- Chapter 6. Coronavirus: Pure Infectious Disease or Genetic Predisposition (Farzaneh Darbeheshti, Hassan Abolhassani, Mohammad Bashashati, Saeid Ghavami, Sepideh Shahkarami, Samaneh Zoghi, Sudhir Gupta, Jordan S. Orange, Hans D. Ochs, Nima Rezaei) -- Chapter 7. Genetic Polymorphisms in the Host and COVID-19 Infection (Joris R. Delanghe, Marc L. De Buyzere, Marijn M. Speeckaert) -- Chapter 8. How COVID-19 Has Globalized: Unknown Origin, Rapid Transmission, and the Immune System Nourishment (Amene Saghazadeh, Nima Rezaei) -- Chapter 9. Potential Anti-viral Immune Response Against COVID-19: Lessons Learned from SARS-CoV (Mahzad Akbarpour, Laleh Sharifi, Amir Reza Safdarian, Pooya Farhangnia, Mahdis Borjkhani, Nima Rezaei) -- Chapter 10. COVID-19 and Cell Stress (Abdo A Elfiky, Ibrahim M Ibrahim, Fatma G Amin, Alaa M Ismail, Wael M Elshemey) -- Chapter 11. Clinical Manifestations of COVID-19 (Mahsa Eskian, Nima Rezaei) -- Chapter 12. Pediatrics and COVID-19 (Tuna Toptan, Sandra Ciesek, Sebastian Hoehl) -- Chapter 13. Geriatrics and COVID-19 (Mona Mirbeyk, Amene Saghazadeh, Nima Rezaei) -- Chapter 14. Coronavirus Diseases in Pregnant Women, the Placenta, Fetus, and Neonate (David A. Schwartz, Amareen Dhaliwal) -- Chapter 15. COVID-19 in Patients with Hypertension (Thiago Quinaglia, Mahsima Shabani, Nima Rezaei) -- Chapter 16. COVID-19 and Cardiovascular Diseases (Babak Geraiely, Niloufar Samiei, Parham Sadeghipour, Azita Haj Hossein Talasaz, Seyedeh Hamideh Mortazavi, Roya Sattarzadeh Badkoubeh) -- Chapter 17. How Prevalent Is Cancer in Confirmed Cases with Coronaviruses and Severe Acute Respiratory Syndromes? (Maryam Fotouhi, Elham Samami, Sahar Mohseni, Amir Nasrollahizadeh, Mohammad Haddadi, Mona Mirbeyk, Amene Saghazadeh, Nima Rezaei) -- Chapter 18. COVID-19 in Patients with Cancer (Ali Nowroozi, Sepideh Razi, Kamal Kant Sahu, Fabio Grizzi, Jann Arends, Mahsa Keshavarz-Fathi, Nima Rezaei) -- Chapter 19. COVID-19 and Tropical Infection: Complexity and Concurrence (Pathum Sookaromdee, Viroj Wiwanitkit) -- Chapter 20. Neurologic Manifestations of COVID-19 (Farnaz Delavari, Farnaz Najmi Varzaneh, Nima Rezaei) -- Chapter 21. Autoimmune Processes Involved in Organ System Failure Following Infection with SARS-CoV-2 (Steven E. Kornguth, Robert J. Hawley) -- Chapter 22. Clinical and Laboratory Predictors of Severity, Criticality, and Mortality in COVID-19: A Multisystem Disease (Bahareh Gholami, Samira Gholami, Amir Hossein Loghman, Behzad Khodaei, Simin Seyedpour, Nasrin Seyedpour, Amene Saghazadeh, Nima Rezaei) -- Chapter 23. Diagnostic Tests for COVID-19 (Tung Phan, Kristin Nagaro) -- Chapter 24. The Role of Medical Imaging in COVID-19 (Houman Sotoudeh, Masoumeh Gity) -- Chapter 25. Therapeutic Development in COVID-19 (Chan Yang, Yuan Huang, Shuwen Liu) -- Chapter 26. Immune-based Therapy for COVID-19 (Abdolreza Esmaeilzadeh, Davood Jafari, Safa Tahmasebi, Reza Elahi, Elnaz Khosh) -- Chapter 27. Ventilatory Support in Patients with COVID-19 (Paolo Maria Leone, Matteo Siciliano, Jacopo Simonetti, Angelena Lopez, Tanzira Zaman, Francesco Varone, Luca Richeldi) -- Chapter 28. Nutrition and Immunity in COVID-19 (Marjan Moallemian Isfahani, Zahra Emam-Djomeh, Idupulapati M. Rao, Nima Rezaei) -- Chapter 29. Dietary Supplements for COVID-19 (Gerard E. Mullin, Berkeley Limektkai, Lin Wang, Patrick Hanaway, Loren Marks, Edward Giovannucci) -- Chapter 30. Photobiomodulation and Antiviral Photodynamic Therapy in COVID-19 Management (Reza Fekrazad, Sohrab Asefi, Maryam Pourhajibagher, Farshid Vahdatinia, Sepehr Fekrazad, Abbas Bahador, Heidi Abrahamse, Michael R Hamblin) -- Chapter 31. The COVID-19 Vaccine Landscape (Till Koch, Anahita Fathi, Marylyn M. Addo) -- Chapter 32. Prevention of COVID-19: Preventive Strategies for General Population, Health Care Settings, and Various Professions (Shirin Moossavi, Kelsey Fehr, Hassan Maleki, Simin Seyedpour, Mahdis Keshavarz-Fath, Farhad Tabasi, Mehrdad Heravi, Rayka Sharifian, Golnaz Shafiei, Negin Badihian, Roya Kelishadi, Shahrzad Nematollahi, Majid Almasi, Saskia Popescu, Mahsa Keshavarz-Fathi, Nima Rezaei) -- Chapter 33. Pharmacist Role and Pharmaceutical Care during the COVID-19 Pandemic (Pedro Amariles, Mónica Ledezma-Morales, Andrea Salazar-Ospina, Jaime Alejandro Hincapié-García) -- Chapter 34. Impact of COVID-19 on Dentistry (Arghavan Tonkaboni, Mohammad Hosein Amirzade-Iranaq, Heliya Ziaei, Amber Ather) -- Chapter 35. The Implications of COVID-19 to Ophthalmology (Tracy H.T. Lai, Emily W.H. Tang, Kenneth K.W. Li) -- Chapter 36. Challenges of Cellular therapy during COVID-19 Pandemic (Kamal Kant Sahu, Sikander Ailawadhi, Natalie Malvik, Jan Cerny) -- Chapter 37. COVID-19 Amid Rumours and Conspiracy Theories: The Interplay between Local and Global Worlds (Inayat Ali) -- Chapter 38. Exploration of the Epidemiological and Emotional Impact of Quarantine and Isolation during COVID‐19 Pandemic (Helia Mojtabavi, Nasirudin Javidi, Anne-Frédérique Naviaux, Pascal Janne, Maximilien Gourdin, Mahsa Mohammadpour, Amene Saghazadeh, Nima Rezaei) -- Chapter 39. The Main Sources and Potential Effects of COVID-19-related Prejudice and Discrimination (Piotr Rzymski, Hanna Mamzer, Michał Nowicki) -- Chapter 40. Potential mechanisms of COVID-19-related psychological problems and mental disorders (Chunfeng Xiao) -- Chapter 41. Mental Health in Health Professionals in the COVID-19 Pandemic (Antonia Bendau, Andreas Ströhle, Moritz Bruno Petzold) -- Chapter 42. Treatment of Patients with Mental Illness Amid a Global COVID-19 Pandemic (Ankit Jain, Kamal Kant Sahu, Paroma Mitra) -- Chapter 43. A Shift in Medical Education During the COVID-19 Pandemic (Farida Nentin1, Nagaraj Gabbur, Adi Katz) -- Chapter 44. Reopening Schools After a Novel Coronavirus Surge (Dan Li, Elizabeth Z. Lin, Marie A. Brault, Julie Paquette, Sten H. Vermund, Krystal J. Godri Pollitt) -- Chapter 45. COVID-19 and Its Impact on Tourism Industry (Dimitrios G. Lagos, Panoraia Poulaki, Penny Lambrou) -- Chapter 46. COVID-19 and Its Global Economic Impact (Zahra Kolahchi, Manlio De Domenico, Lucina Q. Uddin, Valentina Cauda, Igor Grossmann, Lucas Lacasa, Giulia Grancini, Morteza Mahmoudi, Nima Rezaei) -- Chapter 47. Retrieval and Investigation of Data on SARS-CoV-2 and COVID-19 Using Bioinformatics Approach (Muhamad Fahmi, Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Masahiro Ito) -- Chapter 48. Answering the Challenge of COVID-19 Pandemic through Innovation and Ingenuity (Kathryn Clare Kelley, Jonathan Kamler, Manish Garg, Stanislaw P. Stawicki) -- Chapter 49. COVID-19 Pandemic: The Influence of Culture and Lessons for Collaborative Activities (Linda Simon Paulo, George M. Bwire, Xingchen Pan, Tianyue Gao, Amene Saghazadeh, Chungen Pan) -- Chapter 50. A Borderless Solution Is Needed for A Borderless Complexity, Like COVID-19, The Universal Invader (Kawthar Mohamed, Rangarirai Makuku, Eduardo Rodríguez-Román, Aram Pascal Abu Hejleh, Musa Joya, Mariya Ivanovska, Sara A. Makka, Md Shahidul Islam, Nesrine Radwan, Attig-Bahar Faten, Chunfeng Xiao, Leander Marquez, Nima Rezaei) -- Chapter 51. Socialization During The COVID-19 Pandemic: The Role of Social and Scientific Networks During Social Distancing (Sara Momtazmanesh, Noosha Samieefar, Lucina Q. Uddin, Timo Ulrichs, Roya Kelishadi, Vasili Roudenok, Elif Karakoc-Aydiner, Deepak B. Salunke, Jan L. Nouwen, Juan Carlos Aldave Becerra, Duarte Nuno Vieira, Ekaterini Goudouris, Mahnaz Jamee, Morteza Abdullatif Khafaie, Morteza Shamsizadeh, Mohammad Rasoul Golabchi, Alireza Samimiat, Donya Doostkamel, Alireza Afshar, Mohammad Amin Khazeei Tabari, Melika Lotfi, Reza Yari Boroujeni, Niloofar Rambod, Anzhela Stashchak, Alla Volokha, Dainius Pavalkis, André Pereira, Amir Hamzah Abdul Latiff, Rauf Baylarov, Bagher Amirheidari, Mojtaba Hedayati, Antonio Condino-Neto, Nima Rezaei) -- Chapter 52. Interdisciplinary Approaches to COVID-19 (Negar Moradian, Marjan Moallemian, Farnaz Delavari, Constantine Sedikies, Carlos A. Camargo, Jr., Pedro J. Torres, Armin Sorooshian, Saeid Paktinat Mehdiabadi, Juan J. Nieto, Stephane Bordas, Hamid Ahmadieh, Mohammad Abdollahi, Michael R. Hamblin, Frank W. Sellke, Jack Cuzick, Bozkurt Biykem, Michael Schreiber, Babak Eshrati, Georg Perry, Ali Montazeri, Ali Akbar Saboury, Roya Kelishadi, Amirhossein Sahebkar, Ali A. Moosavi-Movahed, Hassan Vatandoost, Mofid Gorji-Bandpy, Bahram Mobasher, Nima Rezaei) -- Chapter 53. Health and Art (HEART): Integrating Science and Art to Fight COVID-19 (Nima Rezaei, Aida Vahed, Heliya Ziaei, Negin Bashari, Saina Adiban Afkham, Fatemeh Bahrami, Sara Bakhshi, Alireza Ghanadan, Atlasi Ghanadan, Nastaran Hosseini, Pariya Kafi, Reihaneh Khalilianfard, Kawthar Mohammed, Sepideh Sargoli, Kosar Tavasoli, Mahya Zare, Amene Saghazadeh).
    Abstract: In December 2019, the world witnessed the occurrence of a new coronavirus to humanity. The disease spread quickly and became known as a pandemic globally, affecting both society and the health care system, both the elderly and young groups of people, and both the men’s and women’s groups. It was a universal challenge that immediately caused a surge in scientific research. Be a part of a world rising in fighting against the pandemic, the Coronavirus Disease - COVID-19 was depicted in the early days of the pandemic, but updated by more than 200 scientists and clinicians to include many facets of this new infectious pandemic, including i, characteristics, ecology, and evolution of coronaviruses; ii, epidemiology, genetics, and pathogenesis (immune responses and oxidative stress) of the disease; iii, diagnosis, prognosis, and clinical manifestations of the disease in pediatrics, geriatrics, pregnant women, and neonates; iv, challenges of co-occurring the disease with tropical infections, cardiovascular diseases, hypertension, and cancer and to the settings of dentistry, hematology, ophthalmology, and pharmacy; v, transmission, prevention, and potential treatments, ranging from supportive ventilator support and nutrition therapy to potential virus- and host-based therapies, immune-based therapies, photobiomodulation, antiviral photodynamic therapy, and vaccines; vi, the resulting consequences on social lives, mental health, education, tourism industry and economy; and vii, multimodal approaches to solve the problem by bioinformatic methods, innovation and ingenuity, globalization, social and scientific networking, interdisciplinary approaches, and art integration. We are approaching December 2020 and the still presence of COVID-19, asking us to call it COVID (without 19).
    Type of Medium: Online Resource
    Pages: XX, 964 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030637613
    Series Statement: Advances in Experimental Medicine and Biology, 1318
    URL: https://doi.org/10.1007/978-3-030-63761-3
    DOI: 10.1007/978-3-030-63761-3
    DDC: 579.2
    Language: English
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    Human Viruses: Diseases, Treatments and Vaccines : The New Insights (2021)
    Cham :Springer International Publishing :
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    Keywords: Virology. ; Public health. ; Diseases. ; Virology. ; Public Health. ; Diseases.
    Description / Table of Contents: Phages as an alternative to antibiotics -- Prevention of Dengue virus infection -- War against Respiratory Syncytial virus -- Global outbreak of Ebola virus disease and strategy to control -- A Polio virus eradication -- Influenza associated thrombotic microangiopathies -- Hepatitis delta: virological and clinical aspects -- Papilloma virus, its molecular pathway and targets -- Human metapneumovirus -- Human fatality by Zika and Chikungunya virus co-infection with prolonged viremia and viruria -- Viral peptide and membrane fusion -- Crimean Congo hemorrhagic fever – an up date -- Zika – a neutropic virus -- Ebola from emergence to epidemic -- Crimean Congo hemorrhagic fever -- Introduction of Epstein Barr virus and lymphoma -- Hepatitis B virus -- Global spread of hemorrhagic fever viruses -- Latent interferon alpha B2 treatment for hepatitis C virus -- vaccine against Crimean Congo Fever virus -- Alpha herpes virus: brief introduction and pathogenecity -- E protein inhibitor or methyl transferase inhibitor of Dengue virus -- Dengue fever again in Pakistan -- Prevalence of Epstein-Barr virus genotypes -- Future use of geospatial techniques.....analysis of Dengue virus -- Management and treatment of Dengue and Chikungunya – natural products to the rescue -- Crimean Congo fever in WHO Eastern Mediterranean region -- Dengue virus infection of primary human smooth muscle cells -- Temperature dependent transmission of potential model for Chikungunya in India -- Immune checkpoints as immune system regulators and potential biomarkers in HIV-1 infection -- The Rabies virus L protein catalyzes mRNA capping with GDP polyribonucleotidyltransferase activity -- Impact of genome changes on virulence of Enterovirus 71 -- Acquired auditory neuropathy spectrum disorder after the attack of Chikungunya -- Review on the antagonist Ebola: a prophylactic approach -- Hijacking the host immune cells by Dengue virus -- Pandemic influenza preparedness in the WHO African regions -- The genetics of post-polio syndrome – an overview -- Zika virus disease in India -- Merkel cell Polyoma virus responsible for Merkel cell carcinoma -- Fitness differences of hepatitis virus genotype D and F -- HCV inhibitors: significance of non-structural polyprotein -- Duel threat: clinical concerns in HIV-HBV-co-infection -- Deciphering emerging Zika and Dengue viral epidemics: implications for global maternal-child health burden -- From Dengue to Zika: the wide spread of mosquito-borne arboviruses -- Causes of high polio vaccine dropout among Pakistani children.
    Abstract: This book discusses current evidence on human viruses and provides an extensive coverage of newly emerged viruses and current strategies for treatment. Offering a new perspective in view of the re-emergence of Ebola in African countries and Dengue in India and Pakistan, the contents include chapters on emergence, pathogenicity, epidemiology and vaccine uptake. Human Viruses: Diseases, Treatments and Vaccines: The New Insights discusses a range of viruses from the most common such as Influenza and Hepatitis to Zika, Poliomyelitis and Chikungunya among many others. It is authored by a team of experts on viral disease and will be of immense use to virologists, public health experts and clinicians.
    Type of Medium: Online Resource
    Pages: XXXIX, 745 p. 272 illus., 135 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030711658
    URL: https://doi.org/10.1007/978-3-030-71165-8
    DOI: 10.1007/978-3-030-71165-8
    DDC: 579.2
    Language: English
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    SARS-CoV-2 Spike Protein Convergent Evolution : Impact of Virus Variants on Efficacy of COVID-19 Therapeutics and Vaccines (2021)
    Cham :Springer International Publishing :
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    Keywords: Virology. ; Immunology. ; Medical microbiology. ; Microbial genetics. ; Virology. ; Immunology. ; Medical Microbiology. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. Why the Spike protein is relevant for COVID19 therapeutics -- Chapter 2. SARS-CoV-2 variants -- Chapter 3. Conclusion.
    Abstract: This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.
    Type of Medium: Online Resource
    Pages: XIII, 136 p. 11 illus., 2 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030873240
    Series Statement: SpringerBriefs in Microbiology,
    URL: https://doi.org/10.1007/978-3-030-87324-0
    DOI: 10.1007/978-3-030-87324-0
    DDC: 579.2
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    Identification of Biomarkers, New Treatments, and Vaccines for COVID-19 (2021)
    Cham :Springer International Publishing :
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    Keywords: Virology. ; Biochemical markers. ; Respiratory organs. ; Physiology. ; Virology. ; Biomarkers. ; Respiratory Physiology.
    Description / Table of Contents: 1. Genetic Aspects and Immune Responses in Covid-19: Important Organ Involvement -- 2. Prevalence of COVID-19 and the Continued Citizen-based Control in Japan -- 3. COVID-19 Pandemicin Brazil: History, Characteristics, and Evolution -- 4. The Experiences of Recovered COVID-19 Patients in Baqiyatallah Hospital: A Qualitative Study -- 5. Age-specific Differences in the Severity of COVID-19 Between Children and Adults: Reality and Reasons -- 6. Sex differences and COVID-19 -- 7. Intestinal Microbiota in the Sars-Cov2 Infection: What is known? -- 8. SARS-CoV-2 Infection and the Kidneys: an Evolving Picture -- 9. Cutaneous Manifestations of COVID-19: Early Diagnosis and Prognostic Information -- 10. How do we Manage Breastfeeding during the COVID-19 Pandemic? -- 11. Deep Learning Analysis in Prediction of COVID-19 Infection Status using Chest CT Scan Features -- 12. Using Ozone Therapy as an Option for Treatment of COVID-19 Patients: A Scoping Review -- 13. COVID-19, Coenzyme Q10 and Selenium -- 14. Topical Oral and Intranasal Antiviral Agents for Coronavirus Disease 2019 (COVID-19) -- 15. Cinnamon: A Promising Natural Product against COVID-19 -- 16. Curcumin and Piperine in COVID-19: a Promising Duo to the Rescue -- 17. Association of in-hospital use of statins, aspirin and renin-angiotensin-aldosterone inhibitors with mortality and ICU admission due to COVID-19A -- 18. The Worldwide Effort to Develop Vaccines for COVID-19.
    Abstract: The novel coronavirus 2019 (COVID-19) has caused a serious global pandemic in just one year. Nearly every country and territory in the world has been affected by the virus. The virulence and infection rate of the virus are profound, and has required extreme social distancing measures across the globe in order to prevent overwhelming the healthcare services and hospitals. COVID-19 appears to have the greatest effects on elderly individuals and those who have co-morbid diseases, such as diabetes and obesity. As the cases and death rate remain high, there are justified fears of this virus remaining for several months or years to come. To address this, a rapid and unprecedented worldwide mobilization effort has begun to identify effective treatments and develop vaccines. As these begin to be deployed and administered across the globe, many now feel the virus will be brought under control and lives will eventually return to normal. This new volume will increase readers’ understanding of the ongoing COVID-19 pandemic through a series of chapters that address these concerns. Leading experts will discuss new treatment approaches, vaccine development, mental health aspects of the pandemic, and convey the results of survey studies. The book will be an excellent resource for researchers studying virology, metabolic diseases, respiratory disorders, and clinical scientists, physicians, drug companies, and healthcare services and workers. .
    Type of Medium: Online Resource
    Pages: IX, 234 p. 28 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030716974
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1327
    URL: https://doi.org/10.1007/978-3-030-71697-4
    DOI: 10.1007/978-3-030-71697-4
    DDC: 579.2
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    Viral Vectors in Veterinary Vaccine Development : A Textbook (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Veterinary microbiology. ; Virology. ; Pharmacology. ; Veterinary Microbiology. ; Virology.
    Description / Table of Contents: Chapter 1. Introduction to Veterinary Vaccines -- Chapter 2. "What is Required to Develop a Viral Vector Vaccine: Key Components of Vaccine-Induced Immune Responses" -- Chapter 3. Viruses and the evolution of viral vectors -- Chapter 4. The role of adjuvants in the application of viral vector vaccines -- Chapter 5. Adenovirus Vectors -- Chapter 6. Poxvirus Vectors -- Chapter 7. The Construction and Evaluation of Herpesvirus Vectors -- Chapter 8. Paramyxoviruses as Vaccine Vectors -- Chapter 9. Rhabdoviruses as vaccine vectors for veterinary pathogens -- Chapter 10. Coronaviruses as Vaccine Vector for Veterinary Pathogens -- Chapter 11. Alphavirus-Based Vaccines -- Chapter 12. Manufacturing and Control of Viral Vectored Vaccines: Challenges -- Chapter 13. Regulatory strategies and factors affecting veterinary viral vector development -- Chapter 14. "Emerging Viral Vectored Technology Future potential of capripoxvirus and African swine fever virus as viral vectors". .
    Abstract: This highly accessible textbook introduces readers to the development of viral vectors and discusses their application in veterinary vaccinology. It offers comprehensive information on the latest advances in this emerging research field, together with a broad overview of the history of veterinary vaccines and viral vectors. The book also addresses issues concerning funding, translational research and ethics that will impact the future development, manufacture and global use of viral vector-based veterinary vaccines. The book addresses the needs of graduate students and researchers in the fields of Veterinary Medicine, Virology and Immunology. .
    Type of Medium: Online Resource
    Pages: XI, 230 p. 35 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030519278
    URL: https://doi.org/10.1007/978-3-030-51927-8
    DOI: 10.1007/978-3-030-51927-8
    DDC: 615
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    Nanoparticles for Rational Vaccine Design (2021)
    Cham :Springer International Publishing :
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    Keywords: Pharmacology. ; Human physiology. ; Nanochemistry. ; Virology. ; Pharmacology. ; Human Physiology. ; Nanochemistry. ; Virology.
    Description / Table of Contents: Preface -- Liposome Formulations as Adjuvants for Vaccines -- Polymeric nanoparticle-based vaccine adjuvants and delivery vehicles -- Virus-like particle vaccines against respiratory viruses and protozoan parasites -- Protein and Peptide Nanocluster Vaccines.
    Abstract: This book introduces nanoparticles as a powerful platform for vaccine design. Current challenges in vaccine development are discussed and the unique advantages nanoparticles provide in overcoming these challenges are explored. The authors offer fascinating insights into the immunological assets of using nanoparticles as delivery vehicles or adjuvants and present different materials that are being used in nanoparticle-based vaccine development, covering peptides, proteins, polymers, virus-like particles, and liposomes. Its contemporary research insights and practical examples for applications make this volume an inspiring read for researchers and clinicians in vaccinology and immunology. Chapter "Liposome Formulations as Adjuvants for Vaccines" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VII, 130 p. 26 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030850678
    Series Statement: Current Topics in Microbiology and Immunology, 433
    URL: https://doi.org/10.1007/978-3-030-85067-8
    DOI: 10.1007/978-3-030-85067-8
    DDC: 615
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  • 18
    Online Resource
    Online Resource
    Vaccination Strategies Against Highly Variable Pathogens (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human physiology. ; Pharmacology. ; Diseases. ; Virology. ; Immunology. ; Human Physiology.
    Description / Table of Contents: Successful Vaccines -- Immunogenicity and Immunodominance in Antibody Responses -- Immunogen Design -- Adjuvants -- Tools to screen vaccines -- Targeting glycans on human pathogens for vaccine design -- BnAbs and highly antigenically variable pathogens.
    Abstract: Vaccines against antigenically stable pathogens, or pathogens that only exist in a limited number of serotypes, have been very successful in the past and have drastically decreased the incidence and lethality of many diseases. However, when it comes to highly variable pathogens or viruses that exist in multiple serotypes, the traditional methods for vaccine development have reached their limits. This volume highlights the development of vaccines against such challenging pathogens. Novel approaches for immunogen design, including structure-guided vaccine development and vaccines targeting glycans, as well as adjuvants and animal models used for testing possible vaccine candidates are outlined and discussed in detail. Given its scope, the book will appeal to scientists in the fields of infectious diseases, microbiology and medicine. .
    Type of Medium: Online Resource
    Pages: VII, 180 p. 16 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030580049
    Series Statement: Current Topics in Microbiology and Immunology, 428
    URL: https://doi.org/10.1007/978-3-030-58004-9
    DOI: 10.1007/978-3-030-58004-9
    DDC: 615
    Language: English
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  • 19
    Online Resource
    Online Resource
    Rabies and Rabies Vaccines (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Virology. ; Immunology. ; Pharmacology. ; Virology. ; Immunology.
    Description / Table of Contents: Rabies Life Cycle, Transmission and Pathogenesis -- History of Rabies and Rabies Vaccines -- Rabies vaccines for wildlife -- Human Rabies Vaccines -- Rabies vaccines, prophylactic, Peru -- Rabies Prevention in Asia: Institutionalizing Implementation Capacities -- Passive Immunity in Rabies Prophylaxis -- Rabies Little Virus Against Powerful Innate Immunity -- Novel Rabies Vaccines -- Assessing the potency of inactivated veterinary vaccines and oral live vaccines against rabies -- WHO Perspective on Rabies.
    Abstract: This book reviews the recent advances in rabies research and rabies vaccine development. The reader is introduced to biology and pathology of the virus, causing agents and the history of rabies vaccination. The book presents regional rabies prophylaxis programs and discusses vaccination strategies for wildlife and humans. Further, innate immune response as well as antibody response to rabies are examined. All chapters are written by renowned experts in rabies research, some of them part of the WHO Collaboration Centre for Rabies Surveillance and Research. The book targets researchers and health professionals working in Virology, Veterinary Medicine and Biomedicine. .
    Type of Medium: Online Resource
    Pages: VII, 205 p. 15 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030210847
    URL: https://doi.org/10.1007/978-3-030-21084-7
    DOI: 10.1007/978-3-030-21084-7
    DDC: 615
    Language: English
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  • 20
    Online Resource
    Online Resource
    HIV Infection in Children and Adolescents (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Virology. ; Diseases. ; Medical microbiology. ; Virology. ; Diseases. ; Medical Microbiology.
    Description / Table of Contents: Foreword -- Introduction and Epidemiology -- Transmission and Pathogenesis -- Diagnosis -- Clinical Manifestation -- Management -- HIV and TB -- Opportunistic Infections -- Immunisation of HIV infected child -- Special Populations, Neonates and Adolescents -- Cure -- HIV and the Microbiome.
    Abstract: This book serves as a reference work on pediatric HIV infection and covers the full bandwidth of topics from an introduction to pathogenesis and epidemiology, over the transmission of the HI virus, to clinical manifestations, treatment, and prevention strategies. Diseases and disorders occurring in HIV infected persons are discussed in detail. The book covers special populations, such as neonates born to an HIV positive mother and adolescents and examines the specific ways of managing HIV disease in these patient groups. This is the first book to cover palliative care as well as ethical, legal and social issues of HIV infection. .
    Type of Medium: Online Resource
    Pages: VIII, 322 p. 35 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030354336
    URL: https://doi.org/10.1007/978-3-030-35433-6
    DOI: 10.1007/978-3-030-35433-6
    DDC: 579.2
    Language: English
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