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  • 1
    Online-Ressource
    Online-Ressource
    LGBT Populations and Cancer in the Global Context (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical policy. ; Quality of life. ; Biomedical Research. ; Health Policy. ; Quality of Life Research.
    Beschreibung / Inhaltsverzeichnis: Foreword: Challenges & Opportunities for LGBT Populations and Cancer in Global Oncology -- Introduction -- Africa -- A Double Dose Of Stigma – Being Gay And Living With Cancer In Kenya -- Sexual Orientation, Gender Identity and Cancer in South Africa -- Americas -- Making the Situation of TLGBI People around Cancer visible: Observations from the Andean Region -- Cancer Care Challenges for the LGBT Population in Brazil -- Cancer and the SGM Population in Canada and the United States of America -- South-East Asia -- The South-East Asia Region: Societal Conditions for LGBT Health and Cancer Research -- Europe -- Foreword: The Eurocentralasian Lesbian* Community Perspective on Cancer and LBQ women: Advocating for more Research and Activism Collaboration -- LGBT+ and Cancer in the WHO European Region: Current Situation in 12 Eastern European and Central Asian Countries -- Sexual and Gender Minorities and Cancer in Germany: The Striking Absence of Understanding their Cancer-related Needs -- LGBT Populations and Cancer in the UK -- Eastern Mediterranean -- LGBT Populations and Cancer in the Eastern Mediterranean Region: Insights and Challenges with a Focus on Lebanon -- Western Pacific -- LGBT Populations and Cancer in Australia and New Zealand -- Challenges in Cancer Control Confronting the LGBT Population in China: Health Risks, Unique Barriers, and Unmet Needs -- What Have We Learned about Cancer and the Global LGBT Community? -- Index.
    Kurzfassung: Lesbian, Gay, Bisexual, and Transgender (LGBT) also known as sexual and gender minority (SGM) populations have been the focus of global attention. Most importantly, LGBT populations have been addressed in the context of human rights in multiple reports and other activities by the United Nations and other international organizations. There is great variation among countries in the recognition of LGBT individuals’ human rights. A global focus on LGBT populations’ health is still limited, with the notable exception of HIV research. This book on LGBT populations and cancer in the global context is, therefore, an important step in that it will broaden the focus on LGBT populations’ health. Globally, cancer is the second leading cause of death. Cancer morbidity and mortality are increasing disproportionately among populations in lower-income countries. A review conducted by the World Health Organization (WHO) found that of the 82% of member states (158) countries, only 35% of the national cancer control plans addresses vulnerable population, including LGBT populations. These findings reflect an increasing awareness about equity when addressing cancer prevention and control, including LGBT populations. This book addresses LGBT populations’ cancer burden across countries that range from high- to low-income countries to support efforts in diverse countries that are working towards reducing LGBT populations’ cancer burden. It documents place-specific challenges that impede progress towards reducing the LGBT cancer burden as well as critically assesses the variation in cancer control efforts that target LGBT populations and cancer to support progress at a global scale. This book includes six sections that cover the six WHO regions, with each chapter written by an author from the specific region s/he is covering. Each chapter makes use of a template that contextualizes the region, local data collection/availability, risk factors, cancer prevention, detection, diagnosis, treatment, and survivorship.
    Materialart: Online-Ressource
    Seiten: X, 335 p. 3 illus., 2 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031065859
    URL: https://doi.org/10.1007/978-3-031-06585-9
    DOI: 10.1007/978-3-031-06585-9
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    An Introduction to Bioanalysis of Biopharmaceuticals (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Biology. ; Pharmaceutical chemistry. ; Biochemistry. ; Pharmacology. ; Cytology. ; Biological Sciences. ; Pharmaceutics. ; Biological Chemistry. ; Pharmacology. ; Cell Biology.
    Beschreibung / Inhaltsverzeichnis: Bioanalytical Support in Drug Discovery and Development,- Monoclonal Antibodies -- Antibody Drug Conjugates (ADCS) -- Bispecifics and Fusion Proteins -- Emerging Modalities-Part A- (Gene Therapy and Cell Therapy) -- Emerging Modalities Part B (Peptides, Oligonucleotide Based Therapy, Vaccines. .
    Kurzfassung: The book provides a comprehensive review of the fundamental and practical aspects of bioanalytical support and the integral role it plays in the development of safe and efficacious biopharmaceutical drugs with speed and cost-effectiveness. The book focuses on a broad range of conventional and emerging biopharmaceutical modalities including monoclonal antibody-based therapeutics, gene therapy, cell therapy, peptides and oligonucleotides. The book starts with an introductory overview of bioanalysis showcasing the integral role it plays in understanding the drug disposition (pharmacokinetics/pharmacodynamics and immunogenicity) and the progression of bioanalytical strategy as the drug progresses through discovery and development stages of the program, taking into consideration the continually evolving regulatory landscape. The book further diversifies into individual biopharmaceutical modalities - monoclonal antibodies, antibody-drug conjugates, bispecifics, Fc-fusion proteins, gene therapies, cell therapies, peptides and oligonucleotides. The individual chapters focus on modality-specific bioanalytical assay strategies, critical reagents, assay formats, analytical platforms, associated bioanalytical challenges and mitigation strategies, industry best practices, and the latest understanding of regulatory guidance as applicable to the fast-growing biopharmaceutical landscape.
    Materialart: Online-Ressource
    Seiten: IX, 160 p. 25 illus., 19 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030971939
    Serie: AAPS Advances in the Pharmaceutical Sciences Series, 57
    URL: https://doi.org/10.1007/978-3-030-97193-9
    DOI: 10.1007/978-3-030-97193-9
    DDC: 570
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Plant Molecular Farming : Applications and New Directions (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Botany. ; Plant biotechnology. ; Pharmaceutical chemistry. ; Agriculture. ; Proteins . ; Plant Science. ; Plant Biotechnology. ; Pharmaceutics. ; Agriculture. ; Protein Biochemistry.
    Beschreibung / Inhaltsverzeichnis: Chapter. 1. Molecular Farming in Plants: Introduction and Applications -- Chapter. 2. Tools and Techniques Used in Plant Molecular Farming -- Chapter. 3. Production of plant natural products in heterologous microbial species -- Chapter. 4. Sustainable Manufacturing of Vaccines, Antibodies, and other Pharmaceuticals -- Chapter. 5. Limitations, Biosafety, ethics, regulatory issues in molecular farming in plants -- Chapter. 6. Conclusion and Perspectives.
    Kurzfassung: Molecular farming is a biotechnological approach that includes the genetic adjustment of agricultural products to create proteins and chemicals for profitable and pharmaceutical purposes. Plant molecular farming describes the manufacture of recombinant proteins and other biologically active product in plants. This approach depends on a genetic transformation of plants that can be accomplished by the methods of stable gene transfer, such as gene transfer to nuclei and chloroplasts, and unstable transfer methods like viral vectors. The requirement for recombinant proteins in terms of quality, quantity, and diversity is increasing exponentially This demand is traditionally met by recombinant protein construction technologies and the engineering of orthodox expression systems based on bacteria or mammalian cell cultures. However, majority of developing countries cannot afford the high costs of medicine derived from such existing methods. Hence, we need to produce not only the new drugs but also the cheaper versions of those already present in the market. Plant molecular farming is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. This book summarizes the advances and challenges of plant molecular farming for all those who are working on or have an interest in this rapidly emerging area of research.
    Materialart: Online-Ressource
    Seiten: IX, 77 p. 10 illus., 9 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031127946
    Serie: SpringerBriefs in Plant Science,
    URL: https://doi.org/10.1007/978-3-031-12794-6
    DOI: 10.1007/978-3-031-12794-6
    DDC: 580
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Lymphocyte Immunization Therapy (LIT) in Reproductive Failures : New Horizons (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Immunology. ; Medicine Research. ; Biology Research. ; Gynecology . ; Human physiology. ; Immunology. ; Biomedical Research. ; Gynecology. ; Human Physiology.
    Beschreibung / Inhaltsverzeichnis: Part I -- Chapter 1: Introduction -- Chapter 2: Recurrent Pregnancy Loss and Recurrent Implantation Failure -- Chapter 3: Immune System -- Chapter 4: Immunology of Pregnancy (Reproductive Immunology) -- Chapter 5: Diagnosis of Alloimmune factor -- Part II -- Chapter 6: Introduction -- Chapter 7: History of LIT -- Chapter 8: Mechanism of Action of LIT -- Chapter 9: Procedure of LIT -- Chapter 10: Safety of LIT -- Chapter 11: Controversies about LIT – REMIS Study -- Chapter 12: Cochrane Reviews & LIT -- Chapter 13: Recent Meta-analyses & LIT -- Chapter 14: Review of International studies of LIT -- Chapter 15: Case Studies -- Chapter 16: Future of LIT.
    Kurzfassung: Recurrent Miscarriages (RM) & Implantation Failure (IF) have remained an enigma to clinicians and researchers. Even after ruling out all possible causative factors, 50-60% cases still remain “Unexplained’. A majority of these so called “Unexplained” cases are now found to have immunological basis. This book is going into the Immunological aspects of these clinical dilemmas, demystifying the role of Immunology and Immunotherapy in RM and IF. The authors have been working in the field of Reproductive Immunology and Immunotherapy for the last 25 years and they have come out with this book combining the international studies with their own experience. The purpose of writing this book is to provide a comprehensive treatise about Immunotherapy, so that it can become an acceptable modality of treatment in cases where it is needed and is effective. The book discusses the basics in Reproductive Immunology. The immunological changes occurring during pregnancy, the role of Cell mediated Immunity (T cells), Humoral Immunity including cytokines is explained. The normal immunological mechanisms protecting the embryo are highlighted and how these mechanisms are disturbed leading to RM and IF, is also explained. The first and the most discussed method of Immunotherapy is Lymphocyte Immunization Therapy (LIT). The book has given a complete overview of LIT, describing how it created euphoria when it was first introduced, how it gradually went into disrepute and how it is now making a comeback. As the authors have personal experience of LIT, the book gives a detailed and complete information about this active form of immunotherapy. The book has a special section on case studies where the authors have given some clinical case reports (including some of their own), who were treated for immunological factor in RM/IF and were treated with Immunotherapy. These cases can be a useful guide to the readers. The book will be useful not only for undergraduate and postgraduate students but also for clinicians in their practice and for researchers for review of developments in the field.
    Materialart: Online-Ressource
    Seiten: XVIII, 147 p. 33 illus., 30 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811929601
    URL: https://doi.org/10.1007/978-981-19-2960-1
    DOI: 10.1007/978-981-19-2960-1
    DDC: 571.96
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Novel Innovation Design for the Future of Health : Entrepreneurial Concepts for Patient Empowerment and Health Democratization (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Biotechnology. ; Medicine Research. ; Biology Research. ; Entrepreneurship. ; New business enterprises. ; Public health. ; Biotechnology. ; Biomedical Research. ; Entrepreneurship. ; Public Health.
    Beschreibung / Inhaltsverzeichnis: Part I. What Is Wrong with Health? What Should the Future of Health Be? -- INNOVATION DESIGN for the FUTURE of HEALTH -- Health Innovations from an Innovators’ Perspective -- From SICKCARE to HEALTHCARE to HEALTH -- Future Look on Health: Opportunities -- Navigating Towards a Future of “One Health” -- Part II. Exponential Medicine + Technologies + Mindset -- Exponential Technologies for an Exponential Medicine -- Exponential Medicine: Challenges of Human Spaceflight Bringing Innovations for Earth—A Case Study -- Healthy Longevity -- The Science of Health Longevity -- Space Healthtech: Innovation Base for Longevity -- Part III. Future Health Value Propositions -- Healthcare the Melting Pot of Technology, Humanity, and Confusion -- Democratize Health Delivery -- Health Innovation Process: Definitions and Short Methodology Introductions -- Prevention, Prediction, Personalization, and Participation as Key Components in Future Health -- Digital Health Business Models: Transformation Is on the Horizon -- Value Propositions for Future Health Developments: Digital, Portable, Connected, Experience-Enhancing, Supportive, Patient-Centric, and Affordable -- (Digital) Patient Journey and Empowerment: Digital Twin -- Part IV. Innovation Methodology Basics -- Stanford Biodesign as Base: Empathy and Patient Centricity as the Main Driver -- Purpose Launchpad Methodology: Introduction -- Design Thinking for Innovations in Healthcare -- VPC to BMC to Exponential Canvas: Canvas Interconnectivity for Exponential Scaling -- Innovation Methodology I3 EME: Awareness for Biomedical Engineers -- Part V. Ethics + Health Innovation -- Integrating Ethical Considerations into Innovation Design -- Part VI. Health Innovation Design -- Case Studies Used Throughout the Book: Innovation Categories Explained -- Why Is Healthcare Different with Respect to Innovation and Entrepreneurial Activities? -- Purpose Launchpad Health (PLH) Methodology Introduction -- Part VII. Purpose Launchpad Health -- Purpose Launchpad Health: Exploration and Evaluation Phases—Actual Case Studies -- Part VIII. Health Leadership, Skills and other Methodologies -- Soft Skills Needed for Problem Understanding and Innovation Generation -- Leadership in Healthcare: A Novel Approach. Healthcare Executives’ Traits, Styles, and Approaches -- Future Skills Framework in Healthcare -- Porter’s Five Forces Analysis: Quo Vadis Immunotherapy Industry -- Part IX. Health Entrepreneurship -- Global Health Markets and Their Different Needs -- Patient: Health Relation and Digital Health Entrepreneurship -- Health Start-Up: Create Impact and be Investment Ready Intra- and Entre-Preneurs -- Regulatory Issues for Health Innovations -- Innovation Think Tank Frameworks for Resolving “The Innovator’s Dilemma” in Healthcare -- A Primer on Patents and IP for Health Innovations -- Successfully Implementing Ambidexterity in the Medical Industry -- Reverse Innovation: Circumvent Digital Health Transformation Issues -- Part X. Health Innovation Education and Incubation -- Health Innovation Design: “CAMPing” for the Unmet Clinical Need -- Health Technology Innovation Generation (HTIG) Lecture and Project Classes at AGH University -- Health Innovation Design at a University: INKA INNOLAB at Otto-von-Guericke-University -- Clinical Innovation at Acibadem Biodesign Center -- Example of a Needs-Driven Innovation Training Program: The BioMedical Design Novo Nordisk Foundation Fellowship Program -- Addressing the Healthcare Needs with Innovation Think Tank Global Infrastructure and its Methodology -- The Power of a Collaborative Ecosystem: Introducing the Edison™ Accelerator -- HealthTec Networks and Clusters (Global): Innovation Clusters in Medtech in Europe -- Leadership-Compass: “Networking and Synapting Empowered by Health Captains” -- Part XI. Purpose Launchpad Health: Toolset Templates and Principles -- PLH Templates and Principles.
    Kurzfassung: This book highlights the reasons for an urgently needed revision of the current global healthcare setup, discusses the needed mindset for a future of health, and provides a comprehensive development toolset for disruption (and for the needed incremental innovations towards disruption). Today’s biomedical and health innovation related research in universities encourages activities that lead to incremental innovations with a relatively low risk of failure. The healthcare industry on the other hand provides tools and devices for established healthcare providers to improve the diagnosis and therapy/ treatment of the patients’ health problems. The patient is not in the center of healthcare provision however, and prevention and prediction are not core goals. The current health setup needs to be challenged and disrupted. Disruptions are coming from technologies or processes that lead to a significant (〉10x) reduction in cost or price/ performance and that also come with new business models. The need for change, effects of exponential technologies, and the needed shift to prevention and to homecare for health democratization and patient empowerment will be discussed in detail in the first parts of the book. The subsequent sections address several innovation methods with a focus on a novel meta methodology named Purpose Launchpad Health. This is followed by a comprehensive discussion on health entrepreneurship activities and needs. The final section of the book addresses how to train students to become entrepreneurial health innovators, presenting successful curricula and examples of health incubation and accelerator setups. All of the innovation tools presented and used in this book are summarized in the final chapter to help the reader get started planning an entrepreneurial venture. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments. Chapters are concise and enriched with key messages, learning objectives and real innovation examples to bridge theory and practice. This book aims to serve as a teaching base for health innovation design and to prepare for health-related entrepreneurial ventures. Readers with medical, biomedical, biotechnology, and health economics backgrounds - and anyone who wants to become a future oriented health innovator or who believes in disruptive approaches - will find this book a useful resource and teaching tool for developing validated products/ services and processes for the future of health.
    Materialart: Online-Ressource
    Seiten: XXXIV, 624 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031081910
    URL: https://doi.org/10.1007/978-3-031-08191-0
    DOI: 10.1007/978-3-031-08191-0
    DDC: 660.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Periodontitis : Advances in Experimental Research (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical microbiology. ; Parasitology. ; Biomedical Research. ; Medical Microbiology. ; Parasitology.
    Beschreibung / Inhaltsverzeichnis: Preface -- Chapter1. Advances in experimental research about periodontitis: lessons from the past, ideas for the future (Julien Santi-Rocca) -- Part I: Periodontal microbiota -- Chapter 2. Microbiota in Periodontitis: advances in the omic era (Shao Bing Fong, Emile Boyer, Martine Bonnaure-Mallet, Vincent Meuric) -- Chapter 3. Aggregatibacter actinomycetemcomitans: from basic to advanced research (Abdelhadi Hbibi, Amal Bouziane, Badiaa Lyoussi, Mimoun Zouhdi, Driss Benazza) -- Chapter 4. Meta-analyses on the Periodontal Archaeome (Jéssica Alves de Cena, Yuri Silvestre-Barbosa, Aline Belmok, Cristine Miron Stefani, Cynthia Maria Kyaw, Nailê Damé-Teixeira) -- Chapter 5. Parasites in periodontal health and disease: a systematic review and meta-analysis (David Felipe Martin-Garcia, Malik Sallam, Gabriela Garcia, Julien Santi-Rocca) -- Chapter 6. Fungi - a component of the oral microbiome involved in periodontal diseases (Justyna Karkowska-Kuleta, Dorota Satala, Magdalena Smolarz, Marcin Zawrotniak, Maria Rapala-Kozik) -- Chapter 7. Herpesviruses in periodontitis: An umbrella review (Aleksandar Jakovljevic, Miroslav Andric, Jelena Jacimovic, Jelena Milasin, Javier Enrique Botero) -- Part II: Periodontitis pathophysiology -- Chapter 8. Recent updates on microbial biofilms in periodontitis: an analysis of in vitro biofilm models (Maick Meneguzzo Prado, Nathalia Figueiredo, Andréa Pimenta, Tamires Szeremeske Miranda, Magda Feres, Luciene Cristina Figueiredo, Josiane de Almeida, Bruno Bueno-Silva) -- Chapter 9. Update on B cell response in periodontitis (Julien Demoersman, Jacques Olivier Pers) -- Chapter 10. Polarization profiles of T lymphocytes and macrophages responses in periodontitis (Franco Cavalla, Marcela Hernández) -- Chapter 11. Complementary experimental methods in genetics open up new avenues of research to elucidate the pathogenesis of periodontitis (Arne S. Schaefer) -- Part III: Periodontitis-associated conditions -- Chapter 12. Update on the bidirectional link between diabetes and periodontitis (Leila Salhi, Michèle Reners) -- Chapter 13. Periodontitis as a risk factor for Alzheimer’s disease: the experimental journey so far, with hope of therapy (Alice Harding, Shalini Kanagasingam, Richard Welbury, Sim K. Singhrao) -- Chapter 14. Cardiovascular diseases and periodontitis (Peter Riis Hansen, Palle Holmstrup) -- Part IV: Therapeutic management of periodontitis -- Chapter 15. Update on the role of cytokines as oral biomarkers in the diagnosis of periodontitis (Triana Blanco-Pintos, Alba Regueira-Iglesias, Carlos Balsa-Castro, Inmaculada Tomás) -- Chapter 16. Non-surgical periodontal treatment: SRP and innovative therapeutic approaches (Alexia Vinel, Antoine Al Halabi, Sébastien Roumi, Hélène Le Neindre, Pierre Millavet, Marion Simon, Constance Cuny, Jean-Sébastien Barthet, Pierre Barthet, Sara Laurencin-Dalicieux) -- Chapter 17. Update on the roles of oral hygiene and plaque control on periodontal disease (Leila Salhi, Bruno De Carvalho, Michèle Reners) -- Chapter 18. Multi-photonic adjunctive therapy for the management of periodontitis: recent advances and new treatment approach (Marco Giannelli, Daniele Bani) -- Chapter 19. Probiotics during the therapeutic management of periodontitis (Flavia Furlaneto, Karin Hitomi Ishikawa, Michel Reis Messora, Marcia P A Mayer) -- Chapter 20. Periodontal cell therapy: a systematic review and meta-analysis (Antoine Dubuc, Valérie Planat-Bénard, Mathieu Marty, Paul Monsarrat, Philippe Kémoun) -- Index.
    Kurzfassung: Periodontitis is a disease that affects more than half the adult population in the world. Treatment is often based on ancient recommendations consisting in mechanically removing material from damaged zones. However, novel therapeutic management strategies exist, from prevention to efficient treatment, and regeneration. The need of integrative approaches to circumvent this worldwide pledge can be achieved through: A better understanding of this complex disease by promoting scientific research and a comprehensive multidisciplinary approach, including epidemiology, microbiology, immunology, physiology, therapeutics, psychology, etc. A better outreach by promoting vulgarization and recommendations for health professionals. A better information of the empowered patients, leading them to consider prevention and to take part in their therapeutic course. The book “Periodontitis: Advances in Experimental Research” includes a timely collection of chapters covering all the fields of research about periodontitis, consisting in concise reviews by the best specialists themselves and with clinical perspectives for periodontitis. Recent technological advances have allowed to explore shadowed areas of periodontology. The book “Periodontitis: Advances in Experimental Research” is a unique occasion to set a milestone for a more integrated field of periodontitis, with a broad scientific, medical, and public audience thanks to dedicated sections in each chapter: Abstract and main body (scientific audience and expert clinicians) Highlights (scientific audience and clinicians) Impact for Practice (clinicians and economical/political decision makers) Summary for Patients (patients and economical/political decision makers).
    Materialart: Online-Ressource
    Seiten: XIII, 402 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030968816
    Serie: Advances in Experimental Medicine and Biology, 1373
    URL: https://doi.org/10.1007/978-3-030-96881-6
    DOI: 10.1007/978-3-030-96881-6
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Online-Ressource
    Online-Ressource
    Biomedical Translational Research : Technologies for Improving Healthcare (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Cancer. ; Technology Sociological aspects. ; Genomics. ; Biomedical Research. ; Cancer Biology. ; Emerging Technologies. ; Genomics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to emerging technologies in biomedical sciences -- Chapter 2. Bioprospecting : boon or curse -- Chapter 3. Growing need for interdisciplinary biomedical research -- Chapter 4. Interplay between theory and experiment : a future approach for biomedical research -- Chapter 5.past, present and future perspectives of biomedical innovation in india -- Chapter 6. Systems biology approaches to study disease comorbidities -- Chapter 7. Bioinformatics the interactome of multidisciplinary approaches -- Chapter 8. Role of artificial intelligence in diagnosis of infectious diseases -- Chapter 9. Dna digital data storage breakthroughs in biomedical research. Chapter 10. Biomedical applications cloud-based iot -- Chapter 11. Next generation sequencing in cancer research -- Chapter 12. Crispr: genome editing and beyond -- Chapter 13. Omics in tuberculosis diagnosis : today and tomorrow -- Chapter 14. Advances in proteomic approaches for chronic kidney disease -- Chapter 15. 3 d bioprinting of tissues and organs : a new paradigm in regenerative medicine and biomedical engineering -- Chapter 16. Virtual planning, rapid prototyping and 3-d printing in orthopedic surgery -- Chapter 17. Tissue chips: contemporary applications and advancementstissue chips: contemporary applications and advancements -- Chapter 18. Flow cytometry for measuring neutrophil function -- Chapter 19. Flow cytometer for understanding genome size variation among medicinal herbs and non-edible oil trees of northeast india -- Chapter 20. Raman spectroscopy applications for bacterial detection -- Chapter 21. Microfluidic point-of-care diagnostic devices: a contemporary relevance. Chapter 22. Fluorescent dots for breast cancer management -- Chapter 23. Molecular mimicry : unravelling the role of autoantibodies in autoimmune diseases and infertility -- Chapter 24. Strategies of vaccine development -- Chapter 25. Preclinical models of intimal hyperplasia and restenosis to predict clinical events and develop novel therapies -- Chapter 26. Sphingolipids : a roadmap from biomarker identification to clinical application -- Chapter 27. Future of gastrointestinal endoscopy -- Chapter 28. Beating heart in a box : the future of cardiac transplant -- Chapter 29. The journey of coronary stent technology -- Chapter 30. Materiovigilance in clinical surgery.
    Kurzfassung: This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.
    Materialart: Online-Ressource
    Seiten: XIII, 505 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811643453
    URL: https://doi.org/10.1007/978-981-16-4345-3
    DOI: 10.1007/978-981-16-4345-3
    DDC: 610.72
    Sprache: Englisch
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  • 8
    Online-Ressource
    Online-Ressource
    The Pathway to Publishing: A Guide to Quantitative Writing in the Health Sciences (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medical sciences. ; Medicine Research. ; Biology Research. ; Science Social aspects. ; Communication in science. ; Penmanship. ; Health Sciences. ; Biomedical Research. ; Science and Technology Studies. ; Science Communication. ; Writing Skills.
    Beschreibung / Inhaltsverzeichnis: Part I. Introduction: The Pathway to Publishing -- Part II. Most common errors -- 1. General research and writing practices -- 2. Content of quantitative papers -- 3. Mechanics of writing -- 4. Grammatical structures and stylistic strategies -- 5. Achieving clarity and conciseness -- 6. Recording scientific data -- 7. Approaching publication -- 8. Slide and poster presentations.
    Kurzfassung: Writing manuscripts is central to the advance of scientific knowledge. For an early career aspiring scientist, writing first author manuscripts is an opportunity to develop critical skills and to credential their expertise. Writing manuscripts, however, is difficult, doubly so for scientists who use English as a second language. Many science students intentionally avoid a writing-intensive curriculum. Careful, thorough reviews of draft manuscripts are difficult to secure, and experienced scientific supervisors face more demands on their time than they have time available. Weak draft manuscripts discourage supervising scientists investing the time to coach revisions. It is easier for experienced scientists to ignore the request, or to simply rewrite the article. Early career scientists are motivated to address these barriers but specific advice is difficult to find, and much of this advice is behind a pay wall. This essential, open access text presents writing lessons organized as common errors, providing students and early-career researchers with an efficient way to learn, and mentors with a quick-reference guide to reviewing. Error descriptions include specific examples drawn from real-world experiences of other early-career writers, and suggestions for how to successfully address and avoid these in the future. Versions of this book have been used by Stanford University, UC Davis, Johns Hopkins, and numerous international institutions and organizations for over a decade. This book is licensed under the terms of the Creative Commons Attribution 4.0 International License "http://creativecommons.org/licenses/by/4.0/", which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made The images or other third party material in this book are included in the book's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the book's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
    Materialart: Online-Ressource
    Seiten: XIII, 186 p. 55 illus., 34 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030981754
    URL: https://doi.org/10.1007/978-3-030-98175-4
    DOI: 10.1007/978-3-030-98175-4
    DDC: 610
    Sprache: Englisch
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  • 9
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    Online-Ressource
    Computer Aided Pharmaceutics and Drug Delivery : An Application Guide for Students and Researchers of Pharmaceutical Sciences (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Pharmaceutical chemistry. ; Pharmacology. ; Drug delivery systems. ; Biotechnology. ; Pharmaceutics. ; Pharmacology. ; Drug Delivery. ; Biotechnology.
    Beschreibung / Inhaltsverzeichnis: History and Present Scenario of Computers in Pharmaceutical Research and Development.-Historical Developments on Computer Applications in Pharmaceutics -- Computer Aided Formulation Development -- Quality-by-Design in Pharmaceutical Development -- Teaching Principles of DoE as an Element of QbD for Pharmacy Students -- Computer-Assisted Manufacturing of Medicines -- Computer Aided Biopharmaceutical Characterization: Gastrointestinal Absorption Simulation and In Silico Computational Modeling -- Computer Simulation and Modeling in Pharmacokinetics and Pharmacodynamics -- Physiologicallly Based Pharmacokinetic Modelling -- Computers in Clinical Development -- Artificial Intelligence (AI) -- Robotic Automation of Pharmaceutical and Life Science Industries -- Soft Robots for the Delivery of Drugs -- Use of Computers and Internet in Scholarly Information Retrieval -- Patent Searching -- Computer Aided Drug Design (CADD) -- Quantitative Structure Property Relationship (QSPR) Modeling Applications in Formulation Development -- Modeling Approaches for Studies of Drug-Polymer Interactions in Drug Delivery Systems -- Computers in Pharmaceutical Analysis -- Telemedicine -- Bioinformatics in Drug-Design and Delivery -- Statistical Modeling Techniques -- Molecular Modelling of Nanoparticles -- Pharmaceutics Informatics: Bio/chemoinformatics in Drug Delivery -- Computer-aided Development and Testing of Human Extra-thoracic Airway Models for Inhalation Drug Delivery.
    Kurzfassung: This book examines the role of computer-assisted techniques for discovering, designing, optimizing and manufacturing new, effective, and safe pharmaceutical formulations and drug delivery systems. The book discusses computational approaches, statistical modeling and molecular modeling for the development and safe delivery of drugs in humans. The application of concepts of QbD (Quality by Design), DoE (Design of Experiments), artificial intelligence and in silico pharmacokinetic assessment/simulation have been made a lot easier with the help of commercial software and expert systems. This title provides in-depth knowledge of such useful software with illustrations from the latest researches. The book also fills in the gap between pharmaceutics and molecular modeling at micro, meso and maro scale by covering topics such as advancements in computer-aided Drug Design (CADD), drug-polymer interactions in drug delivery systems, molecular modeling of nanoparticles and pharmaceutics/bioinformatics. This book provides abundant applications of computers in formulation designing and characterization are provided as examples, case studies and illustrations. Short reviews of software, databases and expert systems have also been added to culminate the interest of readers for novel applications in formulation development and drug delivery. Computer-aided pharmaceutics and drug delivery is an authoritative reference source for all the latest scholarly update on emerging developments in computed assisted techniques for drug designing and development. The book is ideally designed for pharmacists, medical practitioners, students and researchers. .
    Materialart: Online-Ressource
    Seiten: XVII, 762 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811651809
    URL: https://doi.org/10.1007/978-981-16-5180-9
    DOI: 10.1007/978-981-16-5180-9
    DDC: 615.19
    Sprache: Englisch
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  • 10
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    Microbes and Oral Squamous Cell Carcinoma : A Network Spanning Infection and Inflammation (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical microbiology. ; Microbial genetics. ; Industrial microbiology. ; Microbiology. ; Biomedical Research. ; Medical Microbiology. ; Microbial Genetics. ; Industrial Microbiology. ; Microbiology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Epidemiology of Oral Squamous Cell Carcinoma in Indian Scenario -- Chapter 2. Risk factors for Oral Squamous Cell Carcinoma in the Indian population -- Chapter 3. Molecular Carcinopathogenesis in Oral Squamous Cell Carcinoma -- Chapter 4. Inflammation and Infection in Cancer -- Chapter 5. Role of Inflammation and Infection in Oral Squamous Cell Carcinoma -- Chapter 6. Normal Microbiome of Oral cavity -- Chapter 7. Oral Microbiome in Oral Squamous Cell Carcinoma -- Chapter 8. Microbial Dysbiosis in Oral Squamous Cell Carcinoma -- Chapter 9. Bacteria induced carcinopathogenesis in Oral Squamous Cell Carcinoma -- Chapter 10. Virus induced carcinopathogenesis in Oral Squamous Cell Carcinoma -- Chapter 11. Fungi: Culprits or Bystanders in Oral Squamous Cell Carcinoma -- Chapter 12. Microbial ‘omics’ in Oral Squamous Cell Carcinoma -- Chapter 13. Implications and Future perspectives.
    Kurzfassung: This book helps in understanding the relationship between microorganisms and oral carcinogenesis, and the possible oncogenic mechanisms enhancing the association. The book highlights the association between oral cancer, primarily oral squamous cell carcinoma (OSCC), a major global health problem with high incidence and low survival rates with infection and inflammation. Establishing the association of the oral microbiome with cancer risk may lead to significant advances in the understanding cancer etiology, potentially opening a new research paradigm for cancer prevention. The book takes the readers through interesting topics such as the epidemiology and etiology of OSCC, the hallmarks of cancer, and the role of inflammation in OCSS. It presents the difference between the normal and diseased oral microbiome. It further describes the carcino-pathogenesis of various groups. Finally, it discusses the clinical correlation of the observations and what the future looks like for this area of research. The book is interesting for medical students, researchers and clinicians, alike. The knowledge from the book can be exploited practically and used for designing further experiments.
    Materialart: Online-Ressource
    Seiten: XIII, 172 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811905926
    URL: https://doi.org/10.1007/978-981-19-0592-6
    DOI: 10.1007/978-981-19-0592-6
    DDC: 610.72
    Sprache: Englisch
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  • 11
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    Online-Ressource
    Tight Junctions (2022)
    Cham :Springer International Publishing :
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    Schlagwort(e): Cytology. ; Neurosciences. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Cell Biology. ; Neuroscience. ; Biomedical Research. ; Pharmacology.
    Beschreibung / Inhaltsverzeichnis: A historical and evolutionary view of tight junctions -- Tricellular tight junctions -- Mechanosensitivity of tight junctions -- Intracellular traffic and non-canonical roles of ZO-2 protein -- Impact of claudin-2 and occludin expression in inflammation disorders -- Tight junctions in the inflamed gut -- Intestinal barrier disruption by enteropathogenic Escherichia coli -- Tight junction barrier function regulation by microbiota -- Claudin-7 participation in cell-substrate adhesion, cell migration, salt balance in the renal collecting duct and gut cell renewal and differentiation -- Regulation of the alveolar epithelial barrier by claudin-5 -- Regulation of the blood-retinal barrier by occludin phosphorylation, norrin and sonic hedgehog signaling -- Transmigration of metastatic cells through the blood-brain barrier -- Endocytosis of tight junction proteins -- Regulated degradation of claudins. .
    Kurzfassung: This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.
    Materialart: Online-Ressource
    Seiten: XII, 334 p. 47 illus., 44 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030972042
    URL: https://doi.org/10.1007/978-3-030-97204-2
    DOI: 10.1007/978-3-030-97204-2
    DDC: 571.6
    Sprache: Englisch
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  • 12
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    Current Thoughts on Dementia : From Risk Factors to Therapeutic Interventions (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Neurosciences. ; Zoology. ; Medical genetics. ; Biotechnology. ; Medicine Research. ; Biology Research. ; Neuroscience. ; Zoology. ; Medical Genetics. ; Biotechnology. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. ApoE: A Risk Factor for Dementia -- Chapter 2. Infection-Induced Systemic Inflammation and Dementia -- Chapter 3. Role of Impaired Insulin Signaling in the Pathogenesis of Dementia -- Chapter 4. Sex Hormones as Risk Factors of Dementia -- Chapter 5. Mitophagy Impairments as Culprit of Alzheimer’s Disease -- Chapter 6. Parkinson’s Disease: Neurochemistry and Pharmacological Treatment -- Chapter 7. Emerging Roles of TREM2 in Neurodegenerative Diseases -- Chapter 8. Molecular Mechanisms Underlying the Role of HSPB8 in Neurodegeneration -- Chapter 9. Molecular Insights into the Role of ER Stress in Neurodegenerative Diseases. Chapter 10. Role of Hypertension and Hyperlipidemia in the Pathogenesis of Dementia -- Chapter 11. Behavioral Abnormalities of Gut Microbiota and Progression of Dementia -- Chapter 12. Gut-Brain Axis in Alzheimer's Disease: Interplay between Cholecystokinin, Dysbiosis, and Brain-Derived Neurotrophic Factor -- Chapter 13. Cholesterol and Dementia: A Possible Therapeutic Approach -- Chapter 14. Therapeutic Potential of PPARs in Alzheimer’s Disease -- Chapter 15. Exploring the Role of Statins in Reversing the Cognitive and Neurovascular Dysfunctions in Dementia -- Chapter 16. Role of Immunotherapy in Ameliorating Proteopathic Dementia -- Chapter 17. Hypoxic-Hyperoxic Training in Dementia -- Chapter 18. Music Therapy in Dementia -- Chapter 19. Beneficial Effects of Citrus Flavonoids against Aβ Pathology in Alzheimer’s Disease -- Chapter 20. Therapeutic Potential of Phytochemicals: Lessons Learned from Streptozotocin-Induced Sporadic Alzheimer’s Disease -- Chapter 21. Concept of Amnesia and Dementia in Unani System of Medicine -- Chapter 22. Nanotechnological Applications in the Diagnosis and Treatment of Alzheimer’s Dementia.
    Kurzfassung: This informative book discusses the latest research on the risk factors and therapeutics in dementia. WHO calls dementia a public health priority. Dementia manifests as a group of symptoms associated with decline in memory or other thinking skills and is severe enough to reduce a person's ability to perform everyday activities. It occurs frequently among elderly people, but it is not necessarily part of the normal aging process. The book has been divided into two broad sections. The first section reviews the risk factors involved in developing dementia, including various medical conditions, lifestyle choices, as well as genetics. The latter section describes various therapeutic interventions in dementia. Although there is no known cure for dementia, this book underlines the current treatment strategies that could momentarily reduce the symptoms and improve the quality of life of the patients. This book highlights the global effort to find better ways to halt the progression of dementia and develop novel therapeutic strategies. The book would be an interesting read for advanced graduate students and researchers working in the field of neuroscience, genetics, and medicine. It will generate good interest to neurologists, psychiatrists, geriatricians, cardiologists, internal medicine practitioners, epidemiologist, and public health workers.
    Materialart: Online-Ressource
    Seiten: XV, 624 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811676062
    URL: https://doi.org/10.1007/978-981-16-7606-2
    DOI: 10.1007/978-981-16-7606-2
    DDC: 612.8
    Sprache: Englisch
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  • 13
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    Online-Ressource
    Microfluidics and Multi Organs on Chip (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Biomedical engineering. ; Toxicology. ; Cytology. ; Biomedical Research. ; Biomedical Devices and Instrumentation. ; Toxicology. ; Cell Biology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. A Historical and Technological Background to Organs-on-a-Chip -- Chapter 2. Applications of microfluidics -- Chapter 3. Microfluidics based Organ-on-a-chip for cell biology studies -- Chapter 4. Microfluidics in Chemical biology -- Chapter 5. Role of microfluidics in drug delivery -- Chapter 6. Microfluidics in drug discovery -- Chapter 7. Microfludic based sensors -- Chapter 8. Background and Organs-on-a-Chip -- Chapter 9. Culture and co-culture of cells for multi organ on chip -- Chapter 10.Cells and organs on a chip in biomedical sciences -- Chapter 11. Futuristic aspects of organ on a chip -- Chapter 12. Development of Human on a chip -- Chapter 13. Multi-organ on a chip for personalized medicine -- Chapter 14. Development and application of Microfluids in organoid formation -- Chapter 15. Liver on a chip -- Chapter 16. Placenta on Chip: A Modern approach to probe feto-maternal interface -- Chapter 17. Microfluidic retina-on-chip -- Chapter 18. Heart on a chip -- Chapter 19. Kidney on a chip -- Chapter 20. Lungs on a chip -- Chapter 21. Brain on a chip -- Chapter 22. Skin on a chip -- Chapter 23. Organs-on-a-chip in preclinical studies -- Chapter 24. Application of organ on chip in blood brain barrier model -- Chapter 25. Multi organs on a chip in disease modeling -- Chapter 26. Prospects of Medical device on a chip -- Chapter 27. Lab on a chip for precision Medicine -- Chapter 28. Tumour-on-a-chip : Perfusion systems to model the extracellular breast tumour microenvironment:from tumour progression to metastasis formation -- Chapter 29. Building Human In Vitro 3D Models to Replace Animal Studies: During Drug Discovery Reearch: Scientific, Ethical and Regulatory Considerations.
    Kurzfassung: This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.
    Materialart: Online-Ressource
    Seiten: IX, 717 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811913792
    URL: https://doi.org/10.1007/978-981-19-1379-2
    DOI: 10.1007/978-981-19-1379-2
    DDC: 610.72
    Sprache: Englisch
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  • 14
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    Online-Ressource
    Biomedical Translational Research : Drug Design and Discovery (2022)
    Singapore :Springer Nature Singapore :
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    Schlagwort(e): Medicine Research. ; Biology Research. ; Drugs Design. ; Pharmaceutical chemistry. ; Genomics. ; Bioinformatics. ; Biomedical Research. ; Structure-Based Drug Design. ; Pharmaceutics. ; Genomics. ; Bioinformatics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Emerging Technologies : Gateway to Understand Molecular Insight of Diseases, Newer Drugs, Their Design and Targeting -- Chapter 2. Polypharmacology: New Paradigms in Drug Development -- Chapter 3. Drug Repurposing in Biomedical Research : Benefits and Challenges -- Chapter 4. Computational Methods for Drug Repurposing -- Chapter 5. Genomic Approaches for Drug Repositioning -- Chapter 6. Organ-On-A- Chip: Novel in-Vitro Model For Drug Discovery -- Chapter 7. Precision Radiomolecular Oncology: Challenging the Classical Statistical Evidence Based Medicine -- Chapter 8. Drug Repositioning of the Phenylpiperazine Derivative Naftopidil in Prostate Cancer Treatment -- Chapter 9. Biomarker Based Drug Discovery and Reverse Translational Approach -- Chapter 10. Nanotechnology in Dentistry -- Chapter 11. Nanoparticles a Potential Breakthrough in Counteracting Multidrug-Resistant Bacterial Infections: A Holistic View on Underlying Mechanisms and Antibacterial Properties -- Chapter 12. Emerging Role of Cannabinoid System Modulators in Treatment of Cancer -- Chapter 13. Nanodrugs : A Futuristic Approach for Treating Nephrolithiasis -- Chapter 14. Lipo Dermaceuticals : Technological Transformation -- Chapter 15. The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients on Diverse Co-Medications and Antidepressants -- Chapter 16. Role of Microfluidics and Nano Fluidics in Managing CAD -- Chapter 17. Targeted Gene Delivery Through Magnetofection: The New Face of Medicine -- Chapter 18. Qbd-Steered Systematic Development of Drug Delivery Nanoconstructs : Vital Precepts, Retrospect and Prospects -- Chapter 19. Nanoemulsions: A Potential Advanced Nanocarrier Platform for Herbal Drug Delivery -- Chapter 20. Sirna Encapsulated Nanoparticles for Targeting Dorsal Root Ganglion (Drg) in Diabetic Neuropathic Pain -- Chapter 21. EGFR Targeted Quinazoline Clubbed Heterocycles as Anti-Cancer Agents. Chapter 22. Therapeutic Human Monoclonal Antibodies -- Chapter 23. Hydroxyapatites and Their Biomedical Applications -- Chapter 24. Recent Progress in Applications of Magnetic Nanoparticles in Medicine: A Review -- Chapter 25. Chimeric Antigen Receptor T-Cell Therapy: A Cutting Edge Therapy for Multiple Myeloma -- Chapter 26. Nanoparticles-Associated Lipopeptides: A New Class of Antimicrobials -- Chapter 27. Antimicrobial Applications of Engineered Metal-Based Nanomaterials -- Chapter 28. Strengthening Immunity-Ayurveda & Medicinal Plants -- Chapter 29. The Pathophysiology of Liver Disorders and Pharmacotherapy Options with Special Reference to Traditional Herbal Medicines: A Comprehensive Review -- Chapter 30. Polymeric Vehicles for Controlled Delivery of Ayurvedic Drugs for Wound Management.
    Kurzfassung: This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.
    Materialart: Online-Ressource
    Seiten: XII, 599 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811692321
    URL: https://doi.org/10.1007/978-981-16-9232-1
    DOI: 10.1007/978-981-16-9232-1
    DDC: 610.72
    Sprache: Englisch
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  • 15
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    Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases : Volume I: Liver, Skin, Thyroid, Rheumatic & Myopathic Diseases (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Immunology. ; Diseases Causes and theories of causation. ; Autoimmunity. ; Medicine Research. ; Biology Research. ; Immunology. ; Pathogenesis. ; Autoimmunity. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Part I: OVERVIEW OF INFECTIOUS MICROORGANISMS & MICROBIOTA IN INDUCING AUTOIMMUNIT -- Chapter 1. The Concept of Infection Triggered autoimmunity -- Chapter 2. The interaction of gut microbiota with immune system and their effects on immune cell development and function -- Chapter 3. The Link between gut microbiota and autoimmune diseases -- Chapter 4. The factors influencing gut microbiota in autoimmune diseases -- PART II: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF AUTOIMMUNE LIVER DISEASES -- Chapter 5. Microorganisms in pathogenesis and management of Autoimmune hepatitis (AIH) -- Chapter 6. Microorganisms in pathogenesis and management of Primary Biliary Cholangitis -- Chapter 7. Microorganisms in pathogenesis and management of Primary biliary cholangitis -- PART III: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF SKIN AUTOIMMUNE DISEASES -- Chapter 8. Microorganisms in pathogenesis and management of Psoriasis -- Chapter 9. Microorganisms in pathogenesis and management of Vitiligo -- Chapter 10. Microorganisms in pathogenesis and management of Scleroderma (systemic sclerosis) -- Chapter 11. Microorganisms in pathogenesis and management of Atopic Dermatitis -- Chapter 12. Microorganisms in pathogenesis and management of Pemphigus Vulgaris -- Chapter 13. Microorganisms in pathogenesis and management of Bullous pemphigoid -- PART IV: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF AUTOIMMUNE THYROID DISEASES -- Chapter 14. Microorganisms in pathogenesis and management of Graves's Disease -- Chapter 15. Microorganisms in pathogenesis and management of Hashimoto's Thyroiditis -- PART V: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF AUTOIMMUNE RHEUMATIC DISEASES -- Chapter 16. Microorganisms in pathogenesis and management of Rheumatoid Arthritis (RA) -- Chapter 17. Microorganisms in pathogenesis and management of Spondyloarthritis -- Chapter 18. Microorganisms in pathogenesis and management of Ankylosing spondylitis (AS) -- Chapter 19. Microorganisms in pathogenesis and management of Psoriasis Arthritis (PsA) -- Chapter 20. Microorganisms in pathogenesis and management of Systemic Lupus Erythematosus (SLE) -- Chapter 21. Microorganisms in pathogenesis and management of Sjogren’s syndrome -- Chapter 22. Autoimmune Diseases Associated with Chikungunya Infection -- PART VI: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF IDIOPATHIC INFLAMMATORY MYOPATHIES -- Chapter 23. Microorganisms in pathogenesis and management of dermatomyositis (DM) and polymyositis (PM) -- Chapter 24. Microorganisms in pathogenesis and management of necrotizing autoimmune myopathy (NAM) and inclusion body myositis (IBM).
    Kurzfassung: This book in the two volume set provides comprehensive coverage on how microbial pathogens can subvert our immune system into responding against self and resulting into autoimmune diseases. In particular, the book covers the different aspects of linking gut microbiota dysbiosis with autoimmune mechanisms involved in disease development to identify future effective approaches based on the gut microbiota for preventing these autoimmune diseases. Contributions in the book focuses on the role of microbiota/probiotics and their distinct mechanisms exerted in management of autoimmune liver, skin, thyroid, rheumatic and myopathic diseases. This could help in better understanding to design therapeutic strategies that can be deployed to prevent these autoimmune diseases. The book has an interdisciplinary appeal and scholars with an interest immunology, medical microbiology and nutritional sciences will value its contribution. Overall, the book gives a new dimensions and insight in the aspects of microbial role in autoimmune disease pathogenesis and therapeutic aspects.
    Materialart: Online-Ressource
    Seiten: XIX, 680 p. 26 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811919466
    URL: https://doi.org/10.1007/978-981-19-1946-6
    DOI: 10.1007/978-981-19-1946-6
    DDC: 571.96
    Sprache: Englisch
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  • 16
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    Formulating Poorly Water Soluble Drugs (2022)
    Cham :Springer International Publishing :
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    Schlagwort(e): Pharmaceutical chemistry. ; Pharmacology. ; Clinical biochemistry. ; Pharmaceutics. ; Pharmacology. ; Medical Biochemistry.
    Beschreibung / Inhaltsverzeichnis: Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs -- Optimizing the Formulation of Poorly Water-Soluble Drugs -- Solid-State Techniques for Improving Solubility -- Mechanical Particle-Size Reduction Techniques -- Co-solvent and Complexation Systems -- Injectable Formulations of Poorly Water-Soluble Drugs -- Lipid-Based Formulations -- Structured Development Approach for Amorphous Systems -- Melt Extrusion -- Spray-Drying Technology -- Pharmaceutical Cryogenic Technologies -- Precipitation Technologies for Nanoparticle Production -- Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs -- Scientific and Regulatory Considerations for Development and Commercialization of Poorly Water-Soluble Drugs.
    Kurzfassung: The objective of this third edition is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop. Highlights the most recent advancements reported in the literature on technologies to improve the dissolution and bioavailability of poorly water soluble drugs Provides a comprehensive discussion of new technologies developed and recently over 40% updated new content Essential read for scientists and researchers in pharmaceutical, chemical, and agricultural industries since over 80% of newly discovered drugs are poorly water soluble.
    Materialart: Online-Ressource
    Seiten: XII, 693 p. 280 illus., 138 illus. in color. , online resource.
    Ausgabe: 3rd ed. 2022.
    ISBN: 9783030887193
    Serie: AAPS Advances in the Pharmaceutical Sciences Series, 50
    URL: https://doi.org/10.1007/978-3-030-88719-3
    DOI: 10.1007/978-3-030-88719-3
    DDC: 615.19
    Sprache: Englisch
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  • 17
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    Polypharmacology : Principles and Methodologies (2022)
    Cham :Springer International Publishing :
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    Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Drug delivery systems. ; Neuropharmacology. ; Pharmacology. ; Pharmaceutics. ; Drug Delivery. ; Neuropharmacology.
    Beschreibung / Inhaltsverzeichnis: PART I. Polypharmacology as a New Branch of Pharmacology: Concept and Principles -- Basics of Polypharmacology -- Polypharmacology in Clinical Applications: Multitarget Multidrug-combination (MTMD-C) -- Polypharmacology in Clinical Applications: Multitarget Multidrug-single-formulation (MTMD-SF) -- Polypharmacology in Clinical Applications: Multitarget Single-drug (MTSD) -- Polypharmacology in Drug Discovery: Designed Epigenetic MTSD and Small-molecule MTSD -- Anti-cancer Polypharmacology -- Cardiovascular Polypharmacology -- Neuronal Polypharmacology -- Pulmonary Polypharmacology -- Polypharmacology of Metabolic Disease -- Polypharmacology of Infectious Disease -- Polypharmacology of Inflammation -- Anti-psychotics Polypharmacology -- Anti-aging Polypharmacology -- Polypharmacology in Drug Repurposing -- Polypharmacology and Unintended Drug Promiscuity -- Polypharmacology Pharmacokinetics -- The Future of Polypharmacology -- PART II. Polypharmacology in New Drug Development: Strategies and Protocols -- Designed MTSD Discovery Process -- Designed MTSD Discovery Strategies -- Designed MTSD Discovery Technologies -- Designed MTSD Discovery Databases -- Designed MTSD Target Deconvolution.-Designed MTSD Target Validation -- Designed MTSD Lead Identification and Optimization -- Designed MTSD Discovery Protocols -- Natural Products in MTSD Discovery -- Polypharmacology Procedures for Drug Repurposing -- Polypharmacology Procedures for Drug Promiscuity Discovery.
    Kurzfassung: There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on Polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology on Polypharmacology. This book aims to meet the needs of making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of Polypharmacology targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy. Rich in illustrations and tables to showcase readers for better understanding the concepts and technologies related to Polypharmacology; Provides comprehensive, systemic, holistic, and explicit explanations and discussion of the fundamental knowledge, background information, conceptual evolution, and updated methodology, as well as in-depth mechanisms behind the knowledge and methodology of Polypharmacology; Main emphasis on rationally designed Polypharmacology or “multi-target, single-drug (MTD)” pharmacology, which represents the major future direction of Polypharmacology and Pharmacology; Describes the clinical applications of Polypharmacology to various human diseases in the clinical and preclinical settings; Contains a wide collection of the state-of-the-art Polypharmacology technologies applicable to the designed MTD discovery and the step-by-step descriptions of drug discovery process applying Polypharmacology principles and methodologies.
    Materialart: Online-Ressource
    Seiten: XXV, 856 p. 12 illus., 9 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031049989
    URL: https://doi.org/10.1007/978-3-031-04998-9
    DOI: 10.1007/978-3-031-04998-9
    DDC: 615
    Sprache: Englisch
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  • 18
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    Online-Ressource
    Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Pharmacology. ; Nanobiotechnology. ; Biomedical engineering. ; Drug delivery systems. ; Pharmaceutical chemistry. ; Pharmacology. ; Nanobiotechnology. ; Biomedical Engineering and Bioengineering. ; Drug Delivery. ; Pharmaceutics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. An introduction to respiratory diseases and an emerging need for efficient drug delivery systems -- Chapter 2. Inflammatory respiratory diseases: Correlation between Lung cancer and CoVid-19 -- Chapter 3. Advancements in translational respiratory research using nanotechnology -- Chapter 4. Chemical moieties as advanced therapeutics for targeting respiratory disorders -- Chapter 5. Phytochemicals and their nanoformulations targeted for pulmonary diseases -- Chapter 6. Nanocarriers: an advanced and highly effective approach for targeting chronic lung diseases -- Chapter 7. Vesicular drug delivery systems in respiratory diseases -- Chapter 8. Nanoparticles in chronic respiratory diseases -- Chapter 9. Applications of nanotechnology in pulmonary disease diagnosis -- Chapter 10. Nanotechnology in pulmonary disease diagnosis -- Chapter 11. Recent trends in Nanomedicine for diagnosis and treatment of pulmonary diseases -- Chapter 12. Strategies for enhanced drug targeting to inflamed lungs: Novel perspectives -- Chapter 13. Solid-Lipid Nanocarriers (SLN’s) based drug delivery for treating various pulmonary diseases -- Chapter 14. Microparticles, microspheres and microemulsions as pulmonary drug delivery systems for the treatment of respiratory diseases -- Chapter 15. Microparticles, microspheres and microemulsions in respiratory diseases -- Chapter 16. Advanced drug delivery systems targeting the immune system at cellular level in chronic respiratory diseases -- Chapter 17. Targeted Micellar Systems for Pulmonary Disease Intervention -- Chapter 18. Polymeric and inorganic nanoparticles targeting chronic respiratory diseases -- Chapter 19. Mucoadhesive drug delivery system in chronic respiratory diseases -- Chapter 20. Liposomal Drug Delivery: Therapeutic Applications in Chronic Respiratory Diseases -- Chapter 21. Biologics and vaccines for nasal and pulmonary drug delivery -- Chapter 22. Drug delivery systems for respiratory infections -- Chapter 23. Cell and Gene Therapies for Chronic Inflammatory Lung Diseases - Emerging Technological Trends and Advancements in Respiratory Medicine -- Chapter 24. Targeting biofilms in respiratory diseases using novel drug delivery systems -- Chapter 25. Advanced nanomaterials for drug delivery in chronic respiratory disorders -- Chapter 26. Emerging technological trends and advancements in respiratory medicine -- Chapter 27. Pulmonary pharmacokinetics and Biophysics -- Chapter 28. Clinical trials on novel advanced drugs for chronic respiratory disorders.
    Kurzfassung: This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.
    Materialart: Online-Ressource
    Seiten: X, 655 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811643927
    URL: https://doi.org/10.1007/978-981-16-4392-7
    DOI: 10.1007/978-981-16-4392-7
    DDC: 615
    Sprache: Englisch
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  • 19
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    Online-Ressource
    Basic Organic Chemistry for the Life Sciences (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Life sciences. ; Chemistry, Organic. ; Enzymology. ; Biochemistry. ; Biomedical Research. ; Life Sciences. ; Organic Chemistry. ; Enzymology. ; Biochemistry.
    Beschreibung / Inhaltsverzeichnis: 1. Alkanes, composition, constitution, and configuration -- 2. Functional groups -- 3. Electronic structure of organic molecules -- 4. Alkenes and alkynes -- 5. Substitutions on saturated carbon atom -- 6. Nucleophilic additions -- 7. Stereochemistry, symmetry, and molecular chirality -- 8. Derivatives of carboxylic acids -- 9. Electrophilic substitutions -- 10. Pericyclic reactions -- 11. Organic natural products -- 12. Organic supramolecular and supermolecular structures.
    Kurzfassung: This textbook is designed for students of biology, molecular biology, ecology,medicine, agriculture, forestry and other professions where the knowledge of organic chemistry plays an important role. The work may also be of interest to non-professionals, as well as to teachers in high schools. The book consists of 13 chapters that cover the essentials of organic chemistry, including - basic principles of structure and constitution of organic compounds, - the elements of the nomenclature, - the concepts of the nature of chemical bond, - introductions in NMR and IR spectroscopy, - the concepts and main classes of the organic reaction mechanisms, - reactions and properties of common classes or organic compounds, - and the introduction to the chemistry of the natural organic products followed by basic principles of the reactions in living cells. This second edition includes revisions and suggestions made by the readers of the first edition and the author's colleagues. In addition, it includes substantial changes compared to the first edition. The chapter on Cycloaddition has been completed by including the other pericyclic reactions (sigmatropic rearrangements, electrocyclic reactions). The chapter on Organic Natural Products has been extended to include new section covering the principles of organic synthesis. New chapter "Organic Supramolecular and Supermolecular Structures" is added. This chapter covers the basic knowledge about the molecular recognition, supramolecular structures, and the mechanisms of the enzyme catalyzed reactions.
    Materialart: Online-Ressource
    Seiten: XV, 205 p. 339 illus., 114 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2022.
    ISBN: 9783030924386
    URL: https://doi.org/10.1007/978-3-030-92438-6
    DOI: 10.1007/978-3-030-92438-6
    DDC: 610.72
    Sprache: Englisch
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  • 20
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    Online-Ressource
    Macropinocytosis : Functions and Mechanisms (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Cytology. ; Biophysics. ; Cell interaction. ; Biological transport. ; Cell membranes. ; Medicine Research. ; Biology Research. ; Cell Biology. ; Mechanobiological Cell Signaling. ; Membrane Trafficking. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Part 1: Functions of Macropinocytosis -- Chapter 1: Functional Diversity of Macropinocytosis -- Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways -- Chapter 3: The amoebal model for micropinocytosis -- Chapter 4: Extracellular ATP and macropinocytosis -- Chapter 5: Macropinocytosis and Cell Migration: Don't drink an drive -- Chapter 6: Macropinocytosis in phagocyte function and immunity -- Part 2: Signaling Mechanisms Driving Macropinocytosis -- Chapter 7: Roles of 3' Phosphoinositides in Macropinocytosis -- Chapter 8: Signaling pathways that regulate macropinocytosis in mammalian cells -- Chapter 9: Wnt, GSK3 and Macropinocytosis -- Chapter 10: Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis -- Chapter 11: Kras-independent macropinocytosis in pancreatic cancer.
    Kurzfassung: This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process. Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.
    Materialart: Online-Ressource
    Seiten: XI, 224 p. 28 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030940041
    Serie: Subcellular Biochemistry, 98
    URL: https://doi.org/10.1007/978-3-030-94004-1
    DOI: 10.1007/978-3-030-94004-1
    DDC: 571.6
    Sprache: Englisch
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  • 21
    Online-Ressource
    Online-Ressource
    Food Packaging: The Smarter Way (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Food science. ; Nanotechnology. ; Biomedical Research. ; Food Science. ; Food Engineering. ; Food Nanotechnology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Chapter 1. Food packaging industry - An introduction -- Chapter 2. Toward Smarter Food Packaging -- Chapter 3. Novel packaging development, assessment and authentication using smart technologies, non-invasive biometric sensory tools, and artificial intelligence -- Chapter 4. Biodegradable packaging materials and techniques to improve their performance -- Chapter 5. Smart Freshness Indicator for Animal Based Products Packaging - Current Status.-Chapter 6. Packaging of dairy products-Emerging strategies -- Chapter 7. Functional packaging materials for fishery products applications -- Chapter 8. Edible films and coatings: Major challenges and potential applications in food Packaging: A Review.-Chapter 9. Role of sensors to improve food/beverage packaging -- Chapter 10. Functional nanomaterials for food packaging applications -- Chapter 11. Rules and regulations related with packaging.
    Kurzfassung: This book reviews the science and technology of food packaging and covers the potential innovations in the food packaging sector. At the same time, it highlights the issues and prospects for linking the laboratory research to the market. In addition to typical packaging requirements such as food quality, shelf life, protection, communication, and marketing, the book emphasizes the need for novel packaging materials, including biodegradable packaging for a variety of food products. A wide range of food products has been kept in focus and includes animal-based food products such as dairy products and sea foods. The book presents the next level of packaging solutions i.e., smart packaging with the applications of potential tools such as intelligent and active packaging, and includes the latest research on emerging digital technologies for packaging development, assessment, and acceptability. It further highlights the strategies including blends, reinforcing agents, cold plasma, UV light applications, chemical, and enzymatic methods and explores the new opportunities leading to improvement in the packaging performance. Smart freshness indicator applications, including gas and time-temperature indicators for quality and safety of packaged products, have been covered in detail. The book also includes the functional characteristics of edible films and coatings, including their bioactive characteristics. Finally the book presents the rules and regulation related to packaging.
    Materialart: Online-Ressource
    Seiten: XI, 286 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811671968
    URL: https://doi.org/10.1007/978-981-16-7196-8
    DOI: 10.1007/978-981-16-7196-8
    DDC: 610.72
    Sprache: Englisch
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  • 22
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    Online-Ressource
    Introduction to Toxicological Screening Methods and Good Laboratory Practice (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Toxicology. ; Pharmacology. ; Medical sciences. ; Drug development. ; Pharmacy. ; Pharmaceutical chemistry. ; Toxicology. ; Pharmacology. ; Preclinical Research. ; Pharmacy. ; Pharmaceutics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to Toxicology -- Chapter 2. Laboratory Animal models -- Chapter 3. Toxicology Screening Methods -- Chapter 4. Toxicokinetics -- Chapter 5. Safety Pharmacology -- Chapter 6. Good Laboratory Practice.
    Kurzfassung: This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
    Materialart: Online-Ressource
    Seiten: XX, 189 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811660924
    URL: https://doi.org/10.1007/978-981-16-6092-4
    DOI: 10.1007/978-981-16-6092-4
    DDC: 615.90072
    Sprache: Englisch
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  • 23
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    The end of medicine as we know it - and why your health has a future (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Pharmacy. ; Public health. ; Medicine. ; Medical care. ; Medical economics. ; Medicine Research. ; Biology Research. ; Pharmacy. ; Public Health. ; Clinical Medicine. ; Health Care. ; Health Economics. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Prologue: Many questions, no answers -- Part 1: Crisis, what crisis...? -- 1. Too Late -- 2. Don’t Rely on Your Prescription -- 3. Chronic Disease? -- 4. No Prevention -- 5. Male Plus Low Income = Double Whammy -- 6. False Incentives -- 7. The End of Big Pharma -- 8. Research Not for Patients -- 9. Organ-Based Medicine -- 10. Interjection 1: How Healthy Do You Want to Be?.-Part 2: The Medicine of the Future -- 11. Re-Discover the Whole Patient -- 12. Research for patients -- 13. Know Your Genes -- 14. Outnumbered -- 15. Your Exposome -- 16. Big Data Medicine -- 17. Healed -- 18. Well-Tech -- 19. Interjection 2: Superhumans -- Part 3: The Future has Begun... -- 20. Self-diagnosis -- 21. Self-therapy -- 22. Your Digital Twin. Epilogue: Nobody Is Sick Anymore -- Appendix 1: Special Page 1 -- Appendix 2: Special Page 2. .
    Kurzfassung: Medicine itself is sick. We hardly understand any disease and therefore need to chronically treat symptoms but not the causes. Consequently, drugs and other therapies help only very few patients; yet we are pumping more and more money into our healthcare system without any added value and neglect prevention. Thus, the internationally renowned physician scientist, Harald H.H.W. Schmidt, MD, PhD, PharmD, professor at Maastricht University, predicts the end of medicine as we know it. On a positive note, digitization will radically change healthcare and lead to one of the greatest socioeconomic revolutions of mankind. He is one of the pioneers of "systems medicine", a complete redefinition of what we call a "disease", how we organize medicine and how we use Big Data to heal rather than treat, and to prevent rather than cure. In this book the author first proves the deep crisis of medicine, and then also describes how medicine will become more precise, more preventive, safer and, surprisingly, more affordable. “Dr. Harald Schmidt convincingly explains the limitations in the current practice of medicine and the need for big data and a systems approach.” Ferid Murad MD, PhD, Nobel Laureate in Medicine 1998 "Visionary, provocative, and full of insights. Professor Schmidt gives a unique and authoritative perspective to the past, present and future of medical science and clinical practice. And all presented in such an inimitable style." Prof. Robert F. W. Moulds, MBBS PhD FRACP, Former Dean Royal Melbourne Hospital Clinical School of the University of Melbourne, Australia The translation was performed with the help of artificial intelligence (machine translation by the service DeepL.com). Subsequent human revision including updating of each chapter was carried out mainly with a view to internationalization of the content, so that the book reads differently from a simple translation in terms of style and timeliness.
    Materialart: Online-Ressource
    Seiten: XIV, 291 p. 34 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030952938
    URL: https://doi.org/10.1007/978-3-030-95293-8
    DOI: 10.1007/978-3-030-95293-8
    DDC: 615.1
    Sprache: Englisch
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  • 24
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    Online-Ressource
    Macrophage Targeted Delivery Systems : Basic Concepts and Therapeutic Applications (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Cytology. ; Toxicology. ; Immunology. ; Pharmacology. ; Pharmaceutics. ; Cell Biology. ; Toxicology. ; Immunology.
    Beschreibung / Inhaltsverzeichnis: Part I Anatomy, Physiology and Pharmacology of Macrophages -- Introduction to Anatomy and Physiology of Macrophages from Drug Delivery Perspective -- Introduction to Pharmacology of Macrophages from Drug Delivery Perspective -- Mechanisms and Ways of Macrophage Delivery -- Macrophage Associated Disorders: Pathophysiology, Treatment Challenges and Possible Solutions -- Understanding Macrophage Associated Diseases and Applications of Nano Drug Delivery Systems -- Part II Polymeric Nanoparticles for Macrophage Targeting -- Targeting of Macrophages: Basic and therapeutic Role of Polymeric Nanoparticles -- Polymeric Nanoparticles Based Drug and Gene Delivery to Macrophages -- Surface Modification of Nanoparticles for Macrophage Targeting -- Part III Lipid Nanoparticles for Macrophage Targeting -- Liposomes as Delivery System for Macrophage Targeting -- Solid Lipid Nanoparticles Based Drug and Gene Delivery to Macrophages -- In vivo Fate of Colloidal Carriers Undergoing Macrophage Targeting -- Nanoparticle-based Theranostics for Macrophage-associated Diseases -- Part IV Targeting Macrophages for Treatment of Various Diseases -- Tumor Associated Macrophages as Therapeutic Target for Drug/immune Therapy of Cancer -- Macrophage Targeting for Therapy of Autoimmune Diseases -- Macrophage Targeting for Therapy of Cardiovascular Diseases (CVD) -- Macrophage targeting for therapy of intracellular infections -- Targeting Drugs and Nucleic Acids to Macrophages for Therapy of Inflammatory Diseases -- Macrophage Targeted Chemotherapy for Tuberculosis and other Respiratory Disease. -- Part V Specific Formulations and Clinical Trials on Macrophage Targeted Delivery -- Nano- and Microparticles Based Dry Powder Inhalers for Pulmonary Macrophage Drug Delivery -- Recent Trends in Clinical Studies on Macrophage Targeted Delivery -- Future Directions and Challenges in Macrophage Targeting. .
    Kurzfassung: The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders. Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.
    Materialart: Online-Ressource
    Seiten: XVIII, 556 p. 76 illus., 73 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030841645
    URL: https://doi.org/10.1007/978-3-030-84164-5
    DOI: 10.1007/978-3-030-84164-5
    DDC: 615
    Sprache: Englisch
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  • 25
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    Online-Ressource
    Targets of Cancer Diagnosis and Treatment : Ion Transport in Tumor Biology (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Beschreibung / Inhaltsverzeichnis: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.
    Kurzfassung: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges Alina L. Capatina, Dimitris Lagos, and William J. Brackenbury Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer Ana Ramírez, Janice García-Quiroz, Luis Aguilar-Eslava, Yesennia Sánchez-Pérez, and Javier Camacho Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk Jerry J. Fan and Xi Huang Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics Umberto Banderali, Luigi Leanza, Najmeh Eskandari, and Saverio Gentile Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research Marie Potier-Cartereau, William Raoul, Gunther Weber, Karine Mahéo, Raphael Rapetti-Mauss, Maxime Gueguinou, Paul Buscaglia, Caroline Goupille, Nelig Le Goux, Souleymane Abdoul-Azize, Thierry Lecomte, Gaëlle Fromont, Aurélie Chantome, Olivier Mignen, Olivier Soriani, and Christophe Vandier Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions Jason T. Anderson, Kevin M. Huang, Maryam B. Lustberg, Alex Sparreboom, and Shuiying Hu Ion Transport and Radioresistance Bastian Roth and Stephan M. Huber Ion Transporting Proteins and Cancer: Progress and Perspectives Mustafa B. A. Djamgoz.
    Materialart: Online-Ressource
    Seiten: X, 277 p. 30 illus., 20 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031039942
    Serie: Reviews of Physiology, Biochemistry and Pharmacology, 183
    URL: https://doi.org/10.1007/978-3-031-03994-2
    DOI: 10.1007/978-3-031-03994-2
    DDC: 610.72
    Sprache: Englisch
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  • 26
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    Crime Scene Management within Forensic Science : Forensic Techniques for Criminal Investigations (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Forensic sciences. ; Toxicology. ; Biomedical Research. ; Forensic Science. ; Toxicology.
    Beschreibung / Inhaltsverzeichnis: 1 Forensic Dna Analysis: A Powerful Investigative Tool -- 2 “Crime Scene Management Within Forensic Science-Forensic Techniques For Criminal Investigations -- 3 Small Size, Big Impact: Insects For Cadaver Examination -- 4 Dermatoglyphics & Other Impressions: Deciphering The Potential Of A Unique Hominid Niche -- 5 Postmortem Toxicology: A facet of drugs of expedites crimes -- 6 Forensic Biology: A Passport For Biological Evidence -- 7 Sexual offences: Recent methods of Investigation -- 8 Investigation Of Disaster Victim Identification -- 9 Review On Clinical Forensic Medicine -- 10 Firearms and Ammunitions: A sentient approach in criminal investigation -- 11 Digital and Cyber Forensics: A Contemporary evolution in Forensic Sciences -- 12 Fire Investigation: Arson Or Accidental -- 13 Psychological Evaluations: An Indoor game of Criminal Minds -- 14 Competence of Evidences: A Pragmatic Approach in Court of Law -- 15 Penology: A friend or foe for criminal justice system -- 16 Chain Of Custody: Scaling The Investigation To The Event. .
    Kurzfassung: This book, the second volume of Crime Scene Management in Forensic Sciences, reviews the role and impact of forensic evidence in criminal investigations. It also addresses the importance of post mortem examination in criminal cases. The book investigates the use of insects and arthropods to estimate post mortem intervals during forensic investigations. Further, it discusses the physiological effects of xenobiotics at the time of death, based on their concentration and distribution in the body at autopsy. Importantly, it also discusses digital forensic investigation, which can be used for the analysis of digital evidence produced at a court of law. Lastly, it defines the structure and legal framework of these forensic evidences for the effective administration of the criminal justice system. It is an excellent source of information for forensics scientists and legal professionals.
    Materialart: Online-Ressource
    Seiten: VIII, 418 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811666834
    URL: https://doi.org/10.1007/978-981-16-6683-4
    DOI: 10.1007/978-981-16-6683-4
    DDC: 610.72
    Sprache: Englisch
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  • 27
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    Online-Ressource
    Nuclear Receptors in Human Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Beschreibung / Inhaltsverzeichnis: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Kurzfassung: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Materialart: Online-Ressource
    Seiten: XII, 346 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031118364
    Serie: Advances in Experimental Medicine and Biology, 1390
    URL: https://doi.org/10.1007/978-3-031-11836-4
    DOI: 10.1007/978-3-031-11836-4
    DDC: 610.72
    Sprache: Englisch
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  • 28
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    Medical Visualization and Applications of Technology (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Anatomy. ; Medical education. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Anatomy. ; Medical Education. ; Virtual and Augmented Reality.
    Beschreibung / Inhaltsverzeichnis: Part I. Healthcare -- Chapter 1. Is It Time to FONA Friend? A Novel Mixed Reality Front of Neck Access Simulator -- Chapter 2. “Learning About Skin Breakdown” – Design, Development and Evaluation of an Augmented Reality Application to Inform about Pressure Ulcers (sores) and Moisture Lesions -- Chapter 3. The Use of 3D-Printing and Injection Moulding in the Development of a Low-Cost, Perfused Renal Malignancy Model for Training of Robot-Assisted Laparoscopic Partial Nephrectomy -- Chapter 4. The Co-IMMUNicate App: An Engaging and Entertaining Education Resource on Immunity to Respiratory Viruses -- Part II. Education -- Chapter 5. Application of AR and 3D Technology for Learning Neuroanatomy -- Chapter 6. Communicative Powers of Interactive Digital Mediums in the Field of Polyomics -- Chapter 7. SkilletonVR: Canine Skeleton VR -- Chapter 8. Using Holograms to Engage Young People with Anatomy -- Chapter 9. The Digital Dolphin: Are 3D Mobile Based and Interactive Models a Useful Aid to Volunteers on Stranding Schemes Learning the Basic Anatomy and Pathology of Cetaceans? -- Chapter 10. The Impact of the COVID Crisis on Anatomical Education: A Systematic Review.
    Kurzfassung: This edited book explores the use of technology to enable us to visualize the life sciences in a more meaningful and engaging way. It will enable those interested in visualization techniques to gain a better understanding of the applications that can be used in visualization, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualization techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilization of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. We have something for a diverse and inclusive audience ranging from healthcare, patient education, animal health and disease and pedagogies around the use of technologies in these related fields. The first four chapters cover healthcare and detail how technology can be used to illustrate emergency surgical access to the airway, pressure sores, robotic surgery in partial nephrectomy, and respiratory viruses. The last six chapters in the education section cover augmented reality and learning neuroanatomy, historical artefacts, virtual reality in canine anatomy, holograms to educate children in cardiothoracic anatomy, 3D models of cetaceans, and the impact of the pandemic on digital anatomical educational resources.
    Materialart: Online-Ressource
    Seiten: IX, 323 p. 270 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031067358
    Serie: Biomedical Visualization, 1
    URL: https://doi.org/10.1007/978-3-031-06735-8
    DOI: 10.1007/978-3-031-06735-8
    DDC: 610.72
    Sprache: Englisch
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  • 29
    Online-Ressource
    Online-Ressource
    Pharmacology of Drug Stereoisomers (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Pharmacology. ; Medicinal chemistry. ; Pharmaceutical chemistry. ; Biotechnology. ; Biochemical engineering. ; Pharmacology. ; Medicinal Chemistry. ; Pharmaceutics. ; Biotechnology. ; Bioprocess Engineering.
    Beschreibung / Inhaltsverzeichnis: Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.
    Kurzfassung: The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers). Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
    Materialart: Online-Ressource
    Seiten: XI, 207 p. 174 illus., 6 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811923203
    Serie: Progress in Drug Research, 76
    URL: https://doi.org/10.1007/978-981-19-2320-3
    DOI: 10.1007/978-981-19-2320-3
    DDC: 615
    Sprache: Englisch
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  • 30
    Online-Ressource
    Online-Ressource
    Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Pharmacology. ; Toxicology. ; Pharmaceutical chemistry. ; Pharmacology. ; Toxicology. ; Pharmaceutics.
    Beschreibung / Inhaltsverzeichnis: Therapeutic and toxic concentration of drugs in biological matrices -- Analytical techniques for therapeutic drug monitoring and clinical toxicology -- Plasma therapeutic drug monitoring and clinical toxicology -- Dried blood spots in therapeutic drug monitoring and toxicology -- The role of artificial intelligence in therapeutic drug monitoring and clinical toxicity -- Therapeutic drug monitoring and optimal pharmacotherapy with medicines of narrow therapeutic index -- Therapeutic drug monitoring (TDM) and toxicological studies in alternative biological matrices -- Analyzing data from therapeutic drug monitoring, pharmacokinetics, and clinical toxicology studies -- Reducing toxicity in critically ill patients by using therapeutic drug monitoring -- Quality assurance of samples for therapeutic drug monitoring and clinical toxicology -- Therapeutic drug monitoring and toxicology of anticancer drugs -- Therapeutic drug monitoring and toxicology of immunosuppressant -- Therapeutic drug monitoring and toxicology: relevance of measuring metabolites -- Recent advances in nanosensors for Therapeutic Drug Monitoring (TDM) -- Organ toxicity by immunosuppressive drugs in solid organ transplantation -- Artificial intelligence-based techniques to assess drug toxicity in drug induced liver injury (DILI) disease -- Drug dose and therapy individualization -- Models for drug individualization: patient to population level -- Toxicity evaluation of nanomedicine -- Biochemical indices of drug toxicity -- Therapeutic drug monitoring and clinical toxicology: challenges and future directions.
    Kurzfassung: This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges .
    Materialart: Online-Ressource
    Seiten: XVIII, 381 p. 43 illus., 41 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031123986
    URL: https://doi.org/10.1007/978-3-031-12398-6
    DOI: 10.1007/978-3-031-12398-6
    DDC: 615
    Sprache: Englisch
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  • 31
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    Online-Ressource
    Microbial Engineering for Therapeutics (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Biomedical engineering. ; Industrial microbiology. ; Bioinformatics. ; Synthetic Biology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Industrial Microbiology. ; Computational and Systems Biology. ; Synthetic Biology.
    Beschreibung / Inhaltsverzeichnis: Part 1 Introduction to Microbial Engineering -- 1 Exploring the Potential of Microbial Engineering: The Prospect, Promise and Essence -- Part 2 Microbial Engineering Approaches -- 2 Role of System Biology in Microbial System -- 3 Synthetic Biology: Refining Human Health -- 4 Probiotic Engineering: A focus on Inflammatory Bowel Disease -- 5 Engineering microbes for smart diagnostics & Lab on Chip -- 6 Bacteriophage and Virus Engineering -- 7 CRISPR Technologies: A tool for Engineering Microbes -- Part 3 Health Benefits -- 8 Recombinant Vaccines: The Revolution Ahead -- 9 Microbe-Host Metabolic Interaction- Probiotic Approach -- 10 Designer Microbes: Oncotherapy approach -- 11 The human gut microbiome in health, disease and therapeutics -- 12 Use of Engineered Bacteria for Production of Green Chemicals & Pharmaceuticals -- 13 Fat Fighting Microbes. Part 4 Innovation & Translation -- 14 Scale-up of engineering strain for industrial applications -- 15 Affordable therapeutics through Engineered Microbes -- 16 COVID-19: Lesson Learnt from Diagnostics to therapeutics. .
    Kurzfassung: This book highlights the recent advances in the field of microbial engineering and its application in human healthcare. It underscores the systemic and synthetic biology approaches for engineering microbes and discusses novel treatments for inflammatory bowel diseases based on engineered probiotics. The book also reviews the different options and methods for engineering microbes, ranging from recombinant DNA technology to designing microbes for targeting specific sites and delivering therapeutics. Further, it discusses genetically engineered microorganisms for smart diagnostics and describes current approaches in microbial gene editing using CRISPR-Cas9-based tools. Lastly, it summarizes the potential applications of human microbiome engineering in improving human health and explores potential strategies for scaling-up the production of engineered microbial strains for commercial purposes, as well as the challenges. Given its scope, this book is a valuable resource for students, researchers, academics and entrepreneurs interested in understanding microbial engineering for the production of commercial products.
    Materialart: Online-Ressource
    Seiten: XI, 374 p. 45 illus., 44 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811939792
    URL: https://doi.org/10.1007/978-981-19-3979-2
    DOI: 10.1007/978-981-19-3979-2
    DDC: 610.72
    Sprache: Englisch
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  • 32
    Online-Ressource
    Online-Ressource
    Handbook of Millets - Processing, Quality, and Nutrition Status (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Food science. ; Agriculture. ; Biomedical Research. ; Food Science. ; Agriculture.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Millets-an Overview -- Chapter 2. Millet Cultivation an Overview -- Chapter 3. Millet Storage and Pest Management -- Chapter 4. Major Millets Processing -- Chapter 5. Minor millet processing and its impacts on composition -- Chapter 6. Chemistry of Millets: Major and Minor Constituents -- Chapter 7. Nutritional properties of millets: neglected cereals with potentials to combat malnutrition -- Chapter 8. Post-harvest Treatments and Storage of millets -- Chapter 9. Millet Milling Technologies -- Chapter 10. Effect of Processing on Functional Characteristics, Physiochemical Properties, and Nutritional Accessibility of Millets -- Chapter 11. Emerging Technologies in Millet Processing -- Chapter 12. Millet Food Products -- Chapter 13. Byproducts from Millet Processing Industry -- Chapter 14. Quality Standards for Millets -- Chapter 15. Millet Industry Scenario -- Chapter 16. Toxins in Millets.-.
    Kurzfassung: The book offers an updated perspective on the unique characteristics of millets. Millets are consumed for their health/nutritional benefits, and in the preparation of specialty foods for target groups – from pediatrics to geriatrics. Recent trends suggest the importance of millet in the human diet due to their nutritional importance, ability to grow in high temperatures and drought conditions, and their resistance to pests and diseases. This book highlights different types of millet and discusses their properties as well as nutritional and anti-nutritional values. In addition, the book also provides information on the physiochemical properties, future prospects, current methodologies, and agricultural practices. The last few parts cover the emerging technologies in millet processing, by-products utilization, quality standards, and the current millet industry scenario. The book provides a comprehensive overview of the status of millet processing, quality, and nutraceutical product manufacture. The book is a resourceful read for students and researchers in food sciences, as well as industry experts.
    Materialart: Online-Ressource
    Seiten: VII, 386 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811672248
    URL: https://doi.org/10.1007/978-981-16-7224-8
    DOI: 10.1007/978-981-16-7224-8
    DDC: 610.72
    Sprache: Englisch
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  • 33
    Online-Ressource
    Online-Ressource
    Polymeric nanoparticles for the treatment of solid tumors (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Nanotechnology. ; Cancer Treatment. ; Biomedical Research. ; Nanotechnology. ; Cancer Therapy.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. The tumor microenvironment -- Chapter 2. Methods of formulation of polymeric nanoparticles -- Chapter 3. Natural polymers based nanoparticles targeted to solid tumors -- Chapter 4. Optimization of physicochemical properties of polymeric nanoparticles for targeting solid tumors -- Chapter 5. Passive and active targeting approaches for solid tumors -- Chapter 6. Polymeric nanoparticles entrapping natural drugs for cancer therapy -- Chapter 7. Polymeric nanoparticles entrapping drug combinations targeted to solid tumors -- Chapter 8. Ligands specific to over-expressed receptors in solid tumors -- Chapter 9. Ligand targeted polymeric nanoparticles for cancer chemotherapy -- Chapter 10. Polymeric nanoparticles as theranostics for targeting solid tumors -- Chapter 11. Oral delivery of polymeric nanoparticles for solid tumors -- Chapter 12. Polymeric nanoparticles to target glioblastoma tumors -- Chapter 13. Polymeric nanoparticles to target lung cancer -- Chapter 14. Polymer based nanoplatforms for targeting breast cancer -- Chapter 15. PH-Sensitive polymeric nanoparticles for cancer treatment -- Chapter 16. Polymeric nanoplatforms for targeted treatment of prostate cancer -- Chapter 17. Cellular internalization and toxicity of polymeric nanoparticles -- Chapter 18. Prospects and challenges in the treatment of solid tumors.
    Kurzfassung: This book focuses on the emerging research in the field of treatment of solid tumors or cancer with new drug delivery systems using nanotechnology. Nanotechnology has given us a good scope for development of new innovative drug delivery strategies to increase the therapeutic efficacy of anticancer drugs with reduced off-target side effects. Cancer is one of the main causes of death worldwide due to the limitations of classical therapies such as low solubility of active drugs, toxic side effects on healthy cells and resistance of tumor cells. These issues are partly solved by the recent development of polymeric nanoparticles, which improve drug absorption and the therapeutic index, while reducing side effects. Drug carriers must be biocompatible, biodegradable and non-immunogenic. Coupled to a ligand that has affinity for that particular cell, polymeric nanoparticles are used to target specifically malignant cells or tissues and, in turn, improve drug stability. This book presents the latest advances in the application of polymeric particles for cancer treatment, with focus on the tumor microenvironment, synthesis, active and passive targeting, patents, targeting over-expressed receptors, tumor-targeting ligands, theranostics, glioblastoma tumors, lung cancer, breast cancer, prostate cancer and pH-responsive nanoparticles.
    Materialart: Online-Ressource
    Seiten: X, 512 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031148484
    Serie: Environmental Chemistry for a Sustainable World, 71
    URL: https://doi.org/10.1007/978-3-031-14848-4
    DOI: 10.1007/978-3-031-14848-4
    DDC: 610.72
    Sprache: Englisch
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  • 34
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    Online-Ressource
    Biology of Vascular Smooth Muscle : Vasoconstriction and Dilatation (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Human physiology. ; Physiology. ; Internal medicine. ; Medicine Research. ; Biology Research. ; Human Physiology. ; Physiology. ; Internal Medicine. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Architecture of the vessel wall -- Ultrastructure of vascular smooth muscle -- Vascular endothelium -- Electrical and mechanical properties of vascular smooth muscle -- Biochemistry of the contractile proteins of smooth muscle -- Metabolism of vascular smooth muscle -- Neurotransmitters -- Endothelium-derived factors -- Local metabolic factors -- Shear stress, myogenic response, and blood flow autoregulation -- Intracellular Ca2+ regulation -- Regulation of myosin light chain phosphorylation -- Cyclic AMP signaling -- Cyclic GMP signaling -- MicroRNAs and vasoreactivity -- Extracellular vesicles as unique signaling messengers -- Genetic and epigenetic modification -- Coronary vasoreactivity -- Cerebral vasoreactivity -- Pulmonary vasoreactivity -- Renal vasoreactivity -- Hypoxic vasoreactivity -- Ageing and vasoreactivity.
    Kurzfassung: This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved. It particularly focuses on newly identified vasoactive agents, enzymes and transduction mechanisms. It also discusses the latest findings in the regulation of cerebral, coronary and pulmonary circulation as well as vascular activity under hypoxia and ageing. The second edition intends to update the contents of the first edition with the latest achievements in the regulation of vascular activities from biochemical, structural, genetic, physiological, and pharmacological aspects. In addition, two new chapters related to microRNA and extracellular vesicles have been added to reflect their newly discovered important roles in vascular activities. The contraction and dilatation activities of vasculature are of fundamental importance for maintaining circulation homeostasis and adapting to physiological changes. Over the last four decades, there have been significant advances in our understanding of the biochemical, structural, genetic, physiological, and pharmacological aspects of vascular activity regulation, and these insights into the responsiveness of blood vessels under normal and pathophysiological conditions help to provide valuable weapons in the fight vascular diseases. The book is of interest to researchers and graduate students, both in basic research and in clinic settings, in the field of vascular biology.
    Materialart: Online-Ressource
    Seiten: XV, 424 p. 1 illus. , online resource.
    Ausgabe: 2nd ed. 2022.
    ISBN: 9789811971228
    URL: https://doi.org/10.1007/978-981-19-7122-8
    DOI: 10.1007/978-981-19-7122-8
    DDC: 612
    Sprache: Englisch
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  • 35
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    Online-Ressource
    Drugs Easily Explained (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medical sciences. ; Pharmaceutical chemistry. ; Pharmacy. ; Pharmacology. ; Health Sciences. ; Pharmaceutics. ; Pharmacy. ; Pharmacology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. What Should I Know About Drugs? -- Chapter 2. Painkillers (analgesics) -- Chapter 3. Drugs for Gastrointestinal Disorders -- Chapter 4. Drugs for Respiratory Diseases -- Chapter 5. Drugs for Cardiovascular Diseases -- Chapter 6. Drugs for Metabolic Disorders -- Chapter 7. Drugs for Her and Him -- Chapter 8. Drugs for Neurological Disorders -- Chapter 9. Drugs for Mental Disorders -- Chapter 10. Drugs for Eye Diseases -- Chapter 11. Drugs for Cancer and Autoimmune and Infectious Diseases.
    Kurzfassung: Billions of people worldwide take medicines every day to treat important diseases. In many cases, however, neither the doctor nor the pharmacist has the time to explain to the patient why a particular drug should be taken, how the drug works and what side effects to expect. Written by an experienced and well-known textbook author, this book provides an overview of the most common diseases and the drugs used to treat them. The book is designed for a general audience. It provides patients with essential information about how medications work and what side effects and interactions to expect. Finally, the book gives patients advice on what they can do themselves to improve drug therapy and safety. Summaries, bullet points, tables and diagrams support the information process.
    Materialart: Online-Ressource
    Seiten: XX, 267 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031121883
    URL: https://doi.org/10.1007/978-3-031-12188-3
    DOI: 10.1007/978-3-031-12188-3
    DDC: 610
    Sprache: Englisch
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  • 36
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    Online-Ressource
    Discovery DMPK Quick Guide : Guide to Data Interpretation and integration (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Pharmaceutical chemistry. ; Pharmacy. ; Pharmaceutics. ; Pharmacy.
    Beschreibung / Inhaltsverzeichnis: Goals for DMPK during drug optimizations -- Drug Properties -- DMPK in lead optimization -- Candidate tranlational characterization -- Q&A of DMPK issues and tools for drug discovery -- ADME assays -- Regulatory documents for IND to Support FIH -- Appendix: Chemical nomenclature.
    Kurzfassung: This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.
    Materialart: Online-Ressource
    Seiten: XXI, 228 p. 129 illus., 59 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031106910
    URL: https://doi.org/10.1007/978-3-031-10691-0
    DOI: 10.1007/978-3-031-10691-0
    DDC: 615.19
    Sprache: Englisch
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  • 37
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    Online-Ressource
    Oxygen Transport to Tissue XLIII (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Cytology. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Bioinformatics. ; Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Bioinformatics.
    Beschreibung / Inhaltsverzeichnis: Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury -- Imaging cerebral energy metabolism in healthy infants -- Changes in cerebral oxygenation and systemic physiology during a verbal fluency task: Differences between men and women -- Brain Tissue Conductivity in Focal Cerebral Ischemia -- Physical stress Attenuates Cognitive inhibition: An fNIRS Examination -- Changes in Prefrontal Cortical Oxygenation During Tilt Table Orthostatic Hypotension in Subarachnoid Haemorrhage Patients -- Effects of different optical properties of head tissues on near-infrared spectroscopy Using Monte Carlo Simulations -- Frontal cerebral oxygenation in humans at rest: A mirror symmetry in the correlation with cardiorespiratory activity -- Photomodulation of lymphatic delivery of bevacizumab to the brain: the role of singlet oxygen -- NIRS-based study of local cerebral oxygenation during transcranial direct current stimulation in patients with mild traumatic brain injury -- Postnatal Exposure to Brief Hypoxia Alters Brain VEGF Expression and Capillary Density in Adult Mice -- Impaired Cognitive Performance in Mice Exposed to Prolonged Hyperoxia -- Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain -- Motor Imagery and Frontal Head Oxygenation: An fNIRS Study -- Non-invasive detection of persistent cortical hypoxia in Multiple Sclerosis using frequency domain near-infrared spectroscopy (fdNIRS) -- Evaluation of intraoperative end-tidal Carbon dioxide change relates to length hospitalization in peridiaphragmatic surgery: a pilot study -- Pulmonary Embolism in COVID-19 patients is not related to a worsening in tissue oxygenation -- Cardiovascular risk score and gas exchange in COVID-19 patients: no correlation -- Heme Oxygenase 1/ High Mobility Group Box 1 pathway may have a possible role in Covid-19 ARDS (Acute respiratory distress syndrome): a pilot histological study -- Silent Hypoxemia in COVID-19 pneumonia -- Low Flow and Microvascular Shunts: A Final Common Pathway to Cerebrovascular Disease: A Working Hypothesis -- A case of intracranial vertebral artery stenosis treated with percutaneous transluminal angioplasty and stenting guided by brain oximetry -- Assessment of Optimal Arterial Pressure with Near-Infrared Spectroscopy in Traumatic Brain Injury Patients -- Effects of exercise-diet therapy on cognitive function in healthy elderly people evaluated by deep learning based on basic blood test data -- NIRS studies show reduced interhemispheric functional connectivity in individuals with Multiple Sclerosis that exhibit cortical hypoxia -- Eye Tracking Parameters Correlate With the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study -- Critical closing pressure of cerebral circulation at concomitant moderate-to-severe traumatic brain injury -- Hybrid convolutional neural network (hCNN) for image reconstruction in near-infrared optical tomography -- Cross-frequency coupling between brain and body biosignals: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Machine learning distinguishes familiar from unfamiliar pairs of subjects performing an eye contact task: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates With Asphyxia -- Basic examination of hemoglobin phase of oxygenation and deoxygenation in resting state and task periods in adults using fNIRS -- Development and validation of robust and cost-effective liquid heterogeneous phantom for time domain near-infrared optical tomography -- Effect of Exercise Therapy on Stress Response Evaluated by IoMT Monitoring System -- Improved optical tissue model for tissue oximetry imaging applications -- In vitro validation of a new tissue oximeter using visible light -- Photon and Proton Dose Painting based on Oxygen Distribution – Feasibility Study and Tumour Control Probability Assessment -- Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells -- Feasibility of non-invasive measurement of tumor NAD(H) by in vivo phosphorus-31 magnetic resonance spectroscopy -- Acidosis-induced regulation of Egr1 and Ccn1 in vitro and in experimental tumors in vivo -- Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours -- Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers upon Mild Hyperthermia Delivered by wIRA-Irradiation -- Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy -- Optical Redox Imaging Is Responsive to TGFβ Receptor Signaling in Triple-Negative Breast Cancer Cells -- Evaluation of betulinic acid derivatives as PET tracers for hypoxia-induced carbonic anhydrase IX (CA IX) expression -- Role of the mTOR signaling pathway during extracellular acidosis in tumor cells -- Feasibility Study of Remote Contactless Perfusion Imaging with Consumer-Grade Mobile Camera -- Stability of a Novel PEGylation site on a Putative Hemoglobin Based Oxygen Carrier -- Oxygen storage in stacked phospholipid membranes under an oxygen gradient as a model for myelin sheaths -- Confocal laser and electron microscopic investigation of gap junctions in anaplastic astrocytomas -- A radiation biological analysis of the oxygen effect as a possible mechanism in FLASH -- Assessment of nicotinamide adenine dinucleotide in human tissues by in vivo phosphorus-31 magnetic resonance spectroscopic imaging at 1.5 Tesla -- Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus -- Hemorheologic Enhancement of Cerebral Perfusion increases oxygen supply and reduces Ab plaques deposition in a mouse model of Alzheimer’s Disease -- Calorimetric Characterization of the Binding Reaction Between Human Ferric Hemoglobins and Haptoglobin to Develop a Drug for Removal of Cell-Free Haemoglobin -- Feasibility To Measure Tissue Oxygen Saturation Using Textile-integrated Polymer Optical Fibers -- Effect of Atorvastatin on Microcirculation Evaluated by Vascular Occlusion Test with Peripheral Near lnfrared Spectroscop -- Flow characteristics of the conjugate of anti-CD3 monoclonal antibodies and magnetic nanoparticle in the PBS and the blood vessel -- Cerebrovascular Reserve (CVR) and Stages of Hemodynamic Compromise -- On the mechanism of sustained mitochondrial membrane potential without functioning complex IV -- Further evidence that gradients of extracellular pH direct migration of MDA-MB-231 cells in vitro -- Blood Flow and Respiratory Gas Exchange in the Human Placenta at Term: A Data Update -- Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats -- Changes in Oxygenation Levels During Moderate Altitude Simulation (Hypoxia-Induced): A Pilot Study Investigating the Impact of Skin Pigmentation in Pulse Oximetry -- The Intramuscular Circulation is Affected by Neck and Shoulder Pain -- Intramuscular circulation of the lumbar multifidus in different trunk positions on standing -- Numerical Optimization of a NIRS Device for Monitoring Tissue Oxygen Saturation -- Upper trapezius muscle tonicity, assessed by palpation, relates to change in tissue oxygenation and structure as measured by Time-Domain Near Infrared Spectroscopy -- Perceived exertion correlates with multiple physiological parameters during cardiopulmonary exercise testing -- Systemic and Quadriceps Muscle O2 Dynamics in Subjects without Attenuation Point of Deoxygenated Hemoglobin Concentration during Ramp Cycling Exercise -- Jaw-Clenching Intensity Effects on Masseter Oxygen Dynamics and Fatigue: A NIRS Oximetry Study. .
    Kurzfassung: This book contains most of the scientific contributions during the 48th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), which was held electronically in July 2021. It includes multidisciplinary contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians and covers covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence.
    Materialart: Online-Ressource
    Seiten: XXVI, 446 p. 163 illus., 100 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031141904
    Serie: Advances in Experimental Medicine and Biology, 1395
    URL: https://doi.org/10.1007/978-3-031-14190-4
    DOI: 10.1007/978-3-031-14190-4
    DDC: 571.6
    Sprache: Englisch
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  • 38
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    Online-Ressource
    Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases : Volume II: Kidney, Central Nervous System, Eye, Blood, Blood Vessels & Bowel (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Immunology. ; Diseases Causes and theories of causation. ; Autoimmunity. ; Medicine Research. ; Biology Research. ; Immunology. ; Pathogenesis. ; Autoimmunity. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: PART I: HUMAN MICROBIOME, VACCINES AND AUTOIMMUNITY -- Chapter 1. Autoimmunity and Microbiome -- Chapter 2. The vaccines induced autoimmunity -- Chapter 3. COVID-19 and Autoimmunity -- Chapter 4. The protective discourse between infections and autoimmunity -- PART II: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF AUTOIMMUNE KIDNEY DISEASES & ADRENAL INSUFFICIENCY -- Chapter 5. Microorganisms in pathogenesis and management of Anti-Neutrophil Cytoplasmic Antibody- (ANCA)- Associated Vasculitis -- Chapter 6. Microorganisms in pathogenesis and management of IgA Vasculitis and IgA Nephropathy -- Chapter 7. Microorganisms in pathogenesis and management of immune mediated glomerulopathies -- Chapter 8. Microorganisms in pathogenesis and management of Autoimmune Addison’s Disease (ADD) -- PART III: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF CENTRAL NERVOUS SYSTEM (CNS) DEMYELINATING AUTOIMMUNE DISEASES -- Chapter 9. Microorganisms in pathogenesis and management of Multiple Sclerosis (MS) -- Chapter 10. Microorganisms in pathogenesis and management of Guillain-Barre syndrome (GBS) -- Chapter 11. Microorganisms in pathogenesis and management of Neuromyelitis Optica -- Chapter 12. Microorganisms in pathogenesis and management of Acute Disseminated Encephalomyelitis (ADEM) -- PART IV: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF INFLAMMATORY BOWEL DISEASES (IBDs) -- Chapter 13. Microorganisms in pathogenesis and management of Ulcerative colitis (UC) -- Chapter 14. Microorganisms in pathogenesis and management of Crohn’s disease (CD) -- Chapter 15. Microorganisms in pathogenesis and management of Pouchitis -- Chapter 16. Microorganisms in pathogenesis and management of Coeliac Disease -- PART V: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF AUTOIMMUNE BLOOD & BLOOD VESSEL DISORDERS -- Chapter 17. Microorganisms in pathogenesis and management of Anti-Phospholipid Syndrome (Hughes syndrome) -- Chapter 18. Microorganisms in pathogenesis and management of Behçet Disease (BD) -- Chapter 19. Microorganisms in pathogenesis and management of Immune Thrombocytopenia -- PART VI: MICROORGANISMS IN PATHOGENESIS & MANAGEMENT OF AUTOIMMUNE EYE DISEASES -- Chapter 20. Microorganisms in pathogenesis and management of Autoimmune Uveitis -- Chapter 21. Microorganisms in pathogenesis and management of Autoimmune Retinopathy (AIR) -- Chapter 22. Microorganisms in pathogenesis and management of Type 1 Diabetes (T1D) -- Chapter 23. The influence of the microbiome and genetic associations on immune functions and on autoimmune and autoinflammatory diseases -- Chapter 24. Current challenges in research with exploring the microbial pathomechanisms of Autoimmune diseases -- Chapter 25. Future therapeutic prospects in dealing with autoimmune diseases: Treatment Based on the Microbiome Model.
    Kurzfassung: This book, which is the second volume of Role of Microorganisms in Pathogenesis and Management of Autoimmune Diseases, provides comprehensive coverage on how microbial pathogens can subvert our immune system into responding against self and resulting in autoimmune diseases. In particular, the book covers the different aspects of linking gut microbiota dysbiosis with autoimmune mechanisms involved in disease development to identify future effective approaches based on the gut microbiota for preventing these autoimmune diseases. Contributions in the book focus on the role of microbiota/probiotics and their distinct mechanisms exerted in the management of autoimmune diseases of the kidney, central nervous system, eye, blood vessel, and bowel. This could help in better understanding to design of therapeutic strategies that can be deployed to prevent these autoimmune diseases. The book has an interdisciplinary appeal and scholars with an interest in immunology, medical microbiology, and nutritional sciences will value its contribution. Overall, the book gives new dimension and insight into the aspects of microbial role in autoimmune disease pathogenesis.
    Materialart: Online-Ressource
    Seiten: XXI, 542 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811948008
    URL: https://doi.org/10.1007/978-981-19-4800-8
    DOI: 10.1007/978-981-19-4800-8
    DDC: 571.96
    Sprache: Englisch
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  • 39
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    Online-Ressource
    Hair Follicle Regeneration (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Stem cells. ; Biotechnology. ; Biomedical Research. ; Stem Cell Biology. ; Biotechnology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. The historical studies underpinning the concept of hair follicle neogenesis (Higgins C, Jahoda C) -- Chapter 2. Hair regeneration and rejuvenation: pipeline of medical and technical strategies (Limbu S, Kemp P) -- Chapter 3. Cells and structures involved in hair follicle regeneration: an introduction (Tsai J, Garza LA) -- Chapter 4. The dermal papilla and hair follicle regeneration: Engineering strategies to improve dermal papilla inductivity (Pantelireis N, Clavel C) -- Chapter 5. Dermal sheath and hair follicle regeneration (Yoshida Y, Tsuboi K, Kishimoto J) -- Chapter 6. Epithelial-mesenchymal interactions between hair follicles and dermal adipose tissue (Ramos R, Plikus MV) -- Chapter 7. Lymphatic vasculature and hair follicle regeneration (Cazorla A, Perez-Moreno M) -- Chapter 8. In vitro and ex vivo hair follicle models to explore therapeutic options for hair regeneration (Bertolini M, Piccini I, McElwee KJ) -- Chapter 9. Extracellular vesicles including exosomes for hair follicle regeneration (Aberdam E, le Riche A, Bordes S, Closs B, Park BS, Aberdam D) -- Chapter 10. Stem cell-based therapies for hair loss: what is the evidence from a clinical perspective? (Park BS, Choi HI) -- Chapter 11. Induced pluripotent stem cell approach for hair follicle regeneration (Pinto A, Terskikh AV) -- Chapter 12. Biofabrication technologies in hair neoformation (Abreu CM, Gasperini L, Marques AP) -- Chapter 13. Wound healing induced hair follicle regeneration (Jiang Y, Myung P) -- Chapter 14. Hair follicles in wound healing and skin remodeling (Plotczyk M, Jimenez F) .
    Kurzfassung: This book aims to comprehensively review the current cell-based strategies under investigation to achieve the regeneration of human hair follicles. The unique capacity of the human hair follicle to self-renew explains why this complex “mini-organ” has always attracted so much interest as a model for researchers to study stem cell biology and regenerative medicine. The hair follicle is considered a main reservoir of cutaneous stem cells, containing several pools of epithelial, melanocyte, and mesenchymal stem cells involved in hair follicle self-regeneration and pigmentation. In addition, while some of the different follicular cell types contribute to hair shaft growth, others participate in very important interfollicular functions such as dermal remodeling, re-epithelialization after wounding, and cutaneous stem cell homeostasis. The idea of human hair follicle regeneration either “de novo” or by activating dormant miniaturized follicles is not new, yet still continues to arouse enormous interest in the pursuit of a definitive cure for baldness. In contrast to hair follicle regeneration in mice, the attempts made with human follicles have been disappointing in terms of efficiency. However, recent advances in stem cell biology—as well as the appearance of new technologies like 3D printing—have revived expectations in this field of research. This book is divided into four sections. The first part includes an overview of the strategies used in hair follicle regeneration and a historical summary of the most important achievements to date. Parts two and three comprise the main body of the book, with detailed descriptions of the cells and tissue structures involved in hair follicle regeneration, followed by an elaboration of the different therapeutic strategies, engineering techniques, and a clinician’s perspective of stem cell-based therapies in hair loss treatments. Finally, the fourth part reviews the important contribution of the hair follicle in healing cutaneous wounds through the regeneration and remodeling of the dermis and epidermis after injury, as well as wound induced hair follicle neogenesis that occurs when the skin is injured.
    Materialart: Online-Ressource
    Seiten: XII, 307 p. 73 illus., 70 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030983314
    Serie: Stem Cell Biology and Regenerative Medicine, 72
    URL: https://doi.org/10.1007/978-3-030-98331-4
    DOI: 10.1007/978-3-030-98331-4
    DDC: 610.72
    Sprache: Englisch
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  • 40
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    Online-Ressource
    Prebiotics, Probiotics and Nutraceuticals (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Pharmacology. ; Clinical medicine Research. ; Medicine Research. ; Biology Research. ; Pharmacology. ; Clinical Research. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Potentiality of Probiotics in Inactivation of Tetrodotoxin -- Chapter 2. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 3. Plant based Bioactive compounds in Cancer Therapeutics -- Chapter 4. Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics -- Chapter 5. Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immunobiological perspectives -- Chapter 6. The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery -- Chapter 7. The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study -- Chapter 8. Prebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives -- Chapter 9. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases. Chapter 10. Implications of probiotics and prebiotics on immune functions -- Chapter 11. Recent Trends in Natural Medicines and Nutraceuticals Research -- Chapter 12. Nutraceuticals-are alternative to modern medicines- Chapter 13. Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban -- Chapter 14. Drosophila melanogaster as an in-vivo model for the investigation of host microbiota interaction -- Chapter 15. Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development of Aquaculture.
    Kurzfassung: The book titled ‘Prebiotics, Probiotics and Nutraceuticals’ is expected to direct many emerging research pathwaysneed at local and global levels for nutrition and food supplements for developing immunity for healthy life. This volume incorporates sixteen seminal papers on issue based research and their practical applications covering latest information and progress on different area of nutritional supplement research fight against disease. The book highlights the frontier issues and applications in nutritional biotechnology with wide coverage of the themes like Potentiality of Probiotics in Inactivation of Tetrodotoxin, Therapeutic Strategy for the Deterrence of COVID-19 with Relevance to Probiotics and Prospectives of Prebiotics, Probiotics and Synbiotics for Sustainable Development in Aquaculture.Plant based Bioactive compounds in Cancer Therapeutics, Recent Trends in Natural Medicines and Nutraceuticals Research, Probiotics as efficacious therapeutic option for treating gut-related diseases: molecular and immune-biological perspectives, The progressive development of probiotics, prebiotics, synbiotics research, and its multipurpose use in the ornamental fishery, The commercial perspective of probiotics, and bioremediating components in aquaculture pond management: A Case Study andPrebiotics as promising therapeutics for treating gut-related disorders : Biochemical and Molecular Perspectives. Prebiotics and Probiotics as Functional Foods: Prospect and Promises in Metabolic Diseases, Implications of probiotics and prebiotics on immune functions. Recent Trends in Natural Medicines and Nutraceuticals Research, Nutraceuticals are alternative to modern medicines, Socio-Economic Study of Prospective of probiotic, prebiotic and synbiotic for sustainable development of aquaculture in Indian Sunderban. This book will be very useful for the scholars, biotechnologists, agricultural scientists, nutritionist, medical doctors, researchers, teachers and students in the emerging field of biotechnology.
    Materialart: Online-Ressource
    Seiten: XVI, 340 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811689901
    URL: https://doi.org/10.1007/978-981-16-8990-1
    DOI: 10.1007/978-981-16-8990-1
    DDC: 615
    Sprache: Englisch
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  • 41
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    Biomedical Translational Research : From Disease Diagnosis to Treatment (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical genetics. ; Diagnosis. ; Molecular biology. ; Cancer. ; Biomedical Research. ; Clinical Genetics. ; Diagnosis. ; Molecular Biology. ; Cancer Biology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Age-Rage Stress In The Pathophysiology Of Atherosclerosis And Its Treatment -- Chapter 2. Stem Cells In Dermatology: What The Future May Hold -- Chapter 3. Current Advances And Future Avenues In Endocrinology -- Chapter 4. Autologous Conditioned Serum In Lumbar And Cervical Radiculopathy: A Systematic Review -- Chapter 5. Bench To Bedside In Ophthalmology -- Chapter 6. Rapid Eye Movement In Sleep And Dream Sleep -- Chapter 7. Novel Cellular-Stress Models With Implications In Understanding And Treating Ent Pathologies -- Chapter 8. Respiratory Disorders : Contemporary Issues In 2020 -- Chapter 9. Discovery Of Hepatitis Viruses And Two Nobel Prizes : A Tale Of Observations Serendipity Collaboration Research Institute Inter Predated And Game Changing Innovation. Chapter 10. Conventional And Modern Approaches For Clinical And Laboratory Diagnosis Of Tuberculosis -- Chapter 11. Gut Microbes In Cardiovascular Diseases -- Chapter 12. Heart Failure – Future Perspectives -- Chapter 13. IL-10 : A Key Molecular In The Mitigation Of Heart Failure -- Chapter 14. Gene Therapy In Liver Disease : Challenges And Outcomes -- Chapter 15. Interrupting Crystal To Calculus Conversion : The Future Of Research In Urolithiasis -- Chapter 16. Stem Cells – Medical Marvel In Management Of Kidney Diseases -- Chapter 17. Deciphering The Code Of Male Infertility : Genetic Tests, Counselling And Molecular Basis Of Spermatogenic Failure -- Chapter 18. Translational Epidemiology In Cancer Research : The Less Travelled Path -- Chapter 19. Adenosine Pathway In Genitourinary Malignancies: A Promising Immunotherapeutic Target -- Chapter 20. Immune Checkpoint Inhibitors In Cancer Therapy: A Ray Of Hope -- Chapter 21. Recent Developments In The Immunotherapeutic Approaches For Cancer Treatment. Chapter 22. Thrombotic Complications In Women : Risks And Prevention -- Chapter 23. Biomedical Science And Women Health -- Chapter 24. Advances In The Role Of Macronutrients In Human Health And Diseases.
    Kurzfassung: The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.
    Materialart: Online-Ressource
    Seiten: XIV, 491 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811688454
    URL: https://doi.org/10.1007/978-981-16-8845-4
    DOI: 10.1007/978-981-16-8845-4
    DDC: 610.72
    Sprache: Englisch
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  • 42
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    Computational Methods for Precision Oncology (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Internal medicine. ; Bioinformatics. ; Biomedical Research. ; Internal Medicine. ; Bioinformatics.
    Beschreibung / Inhaltsverzeichnis: Part One: Basic Concepts in Precision Oncology -- Chapter 1. Design and Implementation of a precision oncology workflow -- Chapter 2. An overview of cancer genome sequencing -- Chapter 3. Software infrastructures for precision medicine workflows -- Part Two: Current Computational Methods and Tools in Precision Oncology -- Chapter 4. Somatic and germline variant calling from next-generation sequencing data -- Chapter 5. Identification of copy number alterations from next-generation sequencing data -- Chapter 6. Genome-wide discovery of large-scale structural variants from next-generation sequencing data -- Chapter 7. Assessment of microsatellite instability from next-generation sequencing data -- Chapter 8. Computational approaches for the investigation of intra-tumor heterogeneity and clonal evolution from bulk sequencing data -- Chapter 9. Analysis of the transcriptome for precision oncology applications -- Chapter 10. Computational methods for drug repurposing -- Chapter 11. Pathway for analysis for precision oncology applications -- Chapter 12. Identification of fusion transcripts from RNA-seq -- Chapter 13. Computational resources for the interpretation of variations in cancer -- Chapter 14. Analysis of electronic health records for precision oncology -- Chapter 15. Network approaches for precision oncology -- Chapter 16. Experimental validation of genomic alterations -- Part Three: Advanced Concepts - The Future of Precision Oncology -- Chapter 17. Molecular profiling of liquid biopsies for precision oncology -- Chapter 18. Artificial intelligence for precision oncology -- Chapter 19. Single-cell technologies in precision oncology -- Chapter 20. Computational approaches for precision immuno-oncology -- Chapter 21. Multi-pmics profiling of the tumor microenvironment -- Chapter 22. Epigenetic and precision oncology -- Chapter 23. Next generation knowledge bases to support precision oncology. .
    Kurzfassung: Precision medicine holds great promise for the treatment of cancer and represents a unique opportunity for accelerated development and application of novel and repurposed therapeutic approaches. Current studies and clinical trials demonstrate the benefits of genomic profiling for patients whose cancer is driven by specific, targetable alterations. However, precision oncologists continue to be challenged by the widespread heterogeneity of cancer genomes and drug responses in designing personalized treatments. Chapters provide a comprehensive overview of the computational approaches, methods, and tools that enable precision oncology, as well as related biological concepts. Covered topics include genome sequencing, the architecture of a precision oncology workflow, and introduces cutting-edge research topics in the field of precision oncology. This book is intended for computational biologists, bioinformaticians, biostatisticians and computational pathologists working in precision oncology and related fields, including cancer genomics, systems biology, and immuno-oncology.
    Materialart: Online-Ressource
    Seiten: XIV, 336 p. 36 illus., 26 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030918361
    Serie: Advances in Experimental Medicine and Biology, 1361
    URL: https://doi.org/10.1007/978-3-030-91836-1
    DOI: 10.1007/978-3-030-91836-1
    DDC: 610.72
    Sprache: Englisch
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  • 43
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    The Immunogenetics of Dermatologic Diseases (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical genetics. ; Immunology. ; Dermatology. ; Biomedical Research. ; Medical Genetics. ; Immunology. ; Biomedical Research. ; Dermatology.
    Beschreibung / Inhaltsverzeichnis: Genetics control of immune responses -- Non-melanoma skin cancer -- Melanoma -- Psoriasis -- Atopic dermatitis -- Contact dermatitis -- Lichen planus -- Pemphigus and pemphigoids -- Morphea and Lichen Sclerosus -- Granuloma annulare and Necrobiosis lipoidica -- Alopecia areata -- Vitiligo -- Acne Vulgaris and Rosacea -- Urticaria and Angioedema -- Cutaneous drug reaction -- Photodermatologic disorders -- Infantile Haemangioma and other vascular malformations.
    Kurzfassung: This book intends to investigate the broad spectrum of genetic changes in immunological processes involved in cutaneous diseases. One of the main goals of immunogenetic studies is finding susceptibility genes for complex diseases. This can provide an insight into the pathogenesis of the condition in a way that is not easily achievable through other kinds of studies. Thus they are a rational initial step for generating hypotheses about disease pathogenesis. This may especially benefit dermatology, a field notorious for having too many diseases with unknown etiologies. Immunogenetic investigations have made targeted treatment strategies possible for diseases such as psoriasis and pemphigus. Even though these strategies have revolutionized the management of chronic dermatological conditions such as psoriasis, still there are a lot of unanswered questions. For instance, psoriasis patients respond very differently to each of the commercially available biological agents. This diversity could be partially explained by the differences in the sets of genes responsible for disease induction in each individual. Thus whole genome sequencing strategies, if feasible at individual levels, might help in tailoring these targeted treatments based on specific genetic backgrounds. Our intention in preparing this book was to explore the broad spectrum of the genetic aspects of immunological processes involved in cutaneous diseases. We have tried to cover most areas of dermatology where enough studies were available to gather a chapter. Still, there is a substantial lack of knowledge on the immunogenetics of many dermatological conditions. We hope that this book would encourage the investigators to fill these gaps of knowledge.
    Materialart: Online-Ressource
    Seiten: XXI, 450 p. 64 illus., 62 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030926168
    Serie: Advances in Experimental Medicine and Biology, 1367
    URL: https://doi.org/10.1007/978-3-030-92616-8
    DOI: 10.1007/978-3-030-92616-8
    DDC: 610.72
    Sprache: Englisch
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  • 44
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    Bone Tumors in Domestic Animals : Comparative Clinical Pathology (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Veterinary medicine. ; Agricultural genome mapping. ; Biomedical Research. ; Veterinary Science. ; Agricultural Genetics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Outline Of Anatomy/Physiology Of Skeletal Tissues -- Chapter 2: Tumors Of The Musculoskeletal System -- Chapter 3: Tumor-Like Lesions Of The Musculoskeletal System -- Chapter 4: General Considerations About Bone Tumors -- Chapter 5: Appendix: Manual For Histological Preparation And Examination Of Tissues Containing Bone And Cartilage.
    Kurzfassung: This book comparatively examines the etiopathogenetic, clinical-pathological, diagnostic and therapeutic strategies of the main bone tumors of domestic animals. The book also includes a description of the most significant aspects of macroscopic, microscopic, immunohistochemical, instrumental, diagnostic imaging and molecular biology aspects of spontaneous bone tumors in Veterinary Medicine, with also interspecies comparative aspects, including the human one. Last but not least, the book provides an overview of the new diagnostic and therapeutic frontiers related to the approach to animal bone tumors. The book serves as essential reading for professionals, researchers and students who work or want to tackle three paths in the field of comparative veterinary bone oncology.
    Materialart: Online-Ressource
    Seiten: XV, 193 p. 90 illus., 84 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030902100
    URL: https://doi.org/10.1007/978-3-030-90210-0
    DOI: 10.1007/978-3-030-90210-0
    DDC: 610.72
    Sprache: Englisch
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  • 45
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    BioSensing, Theranostics, and Medical Devices : From Laboratory to Point-of-Care Testing (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Nanobiotechnology. ; Biotechnology. ; Nanomedicine. ; Biomedical Research. ; Nanobiotechnology. ; Biotechnology. ; Nanomedicine and Nanotoxicology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1_Biosensing: Material, methods and principle of detection -- Chapter 2_Biosensing applications in the development of medical devices -- Chapter 3_Theranostics: basic principles -- Chapter 4_Material and technique advancements in the development of theranostic products -- Chapter 5_Medical device development strategies -- Chapter 6_Research aspects for the development of medical devices -- Chapter 7_Biosensor-based commercialized point-of-care devices -- Chapter 8_Medical devices in clinical set up -- Chapter 9_Clinical validation of medical devices -- Chapter 10_Regulatory steps involved in the validation of medical devices -- Chapter 11_Protocol for registration process of point-of-care device at FDA or equivalent agencies -- Chapter 12_Opportunities and challenges in medical device development -- Chapter 13_Prospective journey of the research idea from laboratory to the user in the clinic. .
    Kurzfassung: This book provides up-to-date information on the prototypes used to develop medical devices and explains the principles of biosensing and theranostics. It also discusses the development of biosensor and application-orientated design of medical devices. In addition to summarizing the clinical validation of the developed techniques and devices and the regulatory steps involved in their commercialization, the book highlights the latest research and translational technologies toward the development of point-of-care devices in the health care. Lastly, it explores the current opportunities, challenges and provides troubleshooting on the use of biosensors in precision medicine. The book is helpful for researchers and medical professionals working in the field of clinical theranostics, and medical-device development wanting to gain a better understanding into the principles and processes involved in the development of biosensors.
    Materialart: Online-Ressource
    Seiten: IX, 376 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811627828
    URL: https://doi.org/10.1007/978-981-16-2782-8
    DOI: 10.1007/978-981-16-2782-8
    DDC: 610.72
    Sprache: Englisch
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  • 46
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    Invasive Diagnostics and Therapy (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Tumors Classification. ; Surgery. ; Cytokines. ; Virology. ; Biomedical Research. ; Cancer Staging. ; Surgery. ; Cytokines and Growth Factors. ; Virology.
    Beschreibung / Inhaltsverzeichnis: Compliance with the Surgery Safety Checklist: An Update on the Status -- Surgical Safety Checklist: Polychromatic or Achromatic Design -- Surgical Strategy and Clinical Outcome in Patients with Bronchial Carcinoids -- Frozen Section or Intraoperative Cytology: Are We Ready for a Paradigm Shift in Thoracic Surgery? -- Clinical Outcome in Patients with Nosocomial COVID-19 Infection After Thoracic Surgery -- Cytological Diagnostic Procedures in Malignant Mesothelioma -- Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions -- Cytokines in Renal Cell Carcinoma: A Step Towards Earlier Detection and Targeted Therapy -- Primary Hyperparathyroidism Secondary to Ectopic Parathyroid Adenoma: A Case Report -- Perception of Well-Being and Quality of Life in Obese Patients After Bariatric Surgery -- Do Multiple Brain Lesions Always Connote Worse Outcomes? Appraisal Evidence from a Tertiary Care Center in Koshi/Purbanchal Province of Nepal -- Radioimaging and Demographic Profiles of Patients with Spontaneous Intracerebral Hemorrhage: A Need for the Pragmatic Referral System -- Anticytokine Treatment of Rheumatoid Arthritis: An Observational Report.
    Kurzfassung: The book is an update on contentious or unsettled issues concerning invasive diagnostic and therapeutic challenges in cancer and related disorders, focusing on the surgical approach. Topics include recommendations for the best practice in using the surgery safety checklist, surgical strategies in a variety of thoracic cancers, renal cell carcinoma, tumors of parathyroid glands, mesothelioma, and bariatric surgeries. The focus is on the diagnostic and therapeutic challenges of aggressive cancerous entities, choosing the most beneficial modes for optimal outcomes and patient survival. Chapters also address radioimaging and therapy outcomes in different intracranial lesions leading to severe neurological disabilities. The areas of medical practice addressed are still veiled in uncertainty, yet-unresolved pathogenetic background, and have a substantial component of empirical rather than evidence-based clinical approach. Pursuing and sharing new ideas and innovations is essential for improving the management and outcome. The book endeavors to disseminate and deliberate on the latest medical knowledge, studies, and advancements in surgical and diagnostic dealing with cancer. The book is addressed to physicians and surgeons, and all allied health care professionals engaged in patient care and therapy.
    Materialart: Online-Ressource
    Seiten: VI, 119 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030988579
    Serie: Clinical and Experimental Biomedicine, 1374
    URL: https://doi.org/10.1007/978-3-030-98857-9
    DOI: 10.1007/978-3-030-98857-9
    DDC: 610.72
    Sprache: Englisch
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  • 47
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    Translational Informatics : Sports and Exercise Medicine (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Bioinformatics. ; Sports sciences. ; Medical informatics. ; Biomedical Research. ; Bioinformatics. ; Sport Science. ; Health Informatics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Ontologies and Knowledge Graphs for Exercise Medicine -- Chapter 2. Participatory exercise medicine and personalized healthcare -- Chapter 3. Integration of genetic and phenotyping data for sports medicine -- Chapter 4. Microbiota, sports and exercise medicine -- Chapter 5. Human immune system and exercise medicine: current process and future directions -- Chapter 6. Circadian Rhythm and Personalized Exercise -- Chapter 7. Data-driven Exercise Medicine for Cardiovascular Disease -- Chapter 8. Physical Activities and Prevention of Neurodegenerative Diseases -- Chapter 9. Exercise guidelines for cancer patients -- Chapter 10. Diabetes as a metabolic disease and translational exercise medicine informatics.
    Kurzfassung: The book provides readers the informatics and data-driven models for the discovery of personalized excise prescriptions applied to different cases. Overdiagnosis or over-treatment often happened since the complex interaction among the lifestyle, genetic, and environmental factors. Sports and exercise are reported efficient to prevent or reduce the risk of diseases, but the interactions between sports/exercise and disease are personalized and complex. Translational informatics is a powerful paradigm and it promotes the transfer of big data, knowledge and models to the precision application of sports to prevent diseases. Sports and exercise may have different effects on diverse diseases including cancers, neurodegenerative disease, and cardiovascular diseases, etc. This book covers many modern informatics models such as ontologies, knowledge graphs, blockchain, participatory medicine, semantic artificial intelligence, big data modeling, and so on. It also describes the challenges for the sports and exercise medical data sharing and standardization, the privacy protection of data as well as the integration of data from genomic level to physiological phenotype level. This book will be helpful to the readers who are interesting in sports and exercise medicine, healthcare, big data modeling, artificial intelligence in medicine and healthcare. .
    Materialart: Online-Ressource
    Seiten: IX, 234 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811691621
    URL: https://doi.org/10.1007/978-981-16-9162-1
    DOI: 10.1007/978-981-16-9162-1
    DDC: 610.72
    Sprache: Englisch
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  • 48
    Online-Ressource
    Online-Ressource
    From Malignant Transformation to Metastasis : Ion Transport in Tumor Biology (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Physiology.
    Beschreibung / Inhaltsverzeichnis: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression -- Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression -- Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer -- Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues -- Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?.
    Kurzfassung: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression Line O. Elingaard-Larsen, Michala G. Rolver, Ester E. Sørensen, and Stine F. Pedersen Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression Ebbe Boedtkjer Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer Larry Fliegel Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues Giorgia Scarpellino, Luca Munaron, Anna Rita Cantelmo, and Alessandra Fiorio Pla Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism? Christian Stock.
    Materialart: Online-Ressource
    Seiten: XV, 175 p. 40 illus., 20 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030998004
    Serie: Reviews of Physiology, Biochemistry and Pharmacology, 182
    URL: https://doi.org/10.1007/978-3-030-99800-4
    DOI: 10.1007/978-3-030-99800-4
    DDC: 610.72
    Sprache: Englisch
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  • 49
    Online-Ressource
    Online-Ressource
    Marine Biomaterials : Drug Delivery and Therapeutic Applications (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Pharmacology. ; Medicine Research. ; Biology Research. ; Biomaterials. ; Pharmacy. ; Biomedical engineering. ; Pharmacology. ; Biomedical Research. ; Biomaterials. ; Pharmacy. ; Translational Research. ; Biomedical Engineering and Bioengineering.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Marine biopolymers for oral delivery of drug -- Chapter 2. Marine polymer based nanocarriers for drug delivery application -- Chapter 3. Alginate: A promising biopolymer in drug delivery system -- Chapter 4. Chitosan Based Nanocomposite as Targeted drug delivery Carrier -- Chapter 5. Marine Biopolymer Based Oral In situ Gel: Drug Delivery Applications -- Chapter 6. Marine biopolymers for transdermal drug delivery -- Chapter 7. Marine polysaccharides for skin drug delivery: hydrogels and microneedles solutions -- Chapter 8. Marine collagen: promising biomaterial in delivery of therapeutics for cancer therapy -- Chapter 9. Chitosan based gel for ocular drug delivery. Chapter 10. Marine based biopolymers for central nervous system drug delivery -- Chapter 11. Marine Biopolymers Based Anticancer Drug Delivery Systems -- Chapter 12. Marine-Derived polysaccharides: prospects for future pharmaceuticals and drug delivery systems.
    Kurzfassung: This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.
    Materialart: Online-Ressource
    Seiten: X, 453 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811647871
    URL: https://doi.org/10.1007/978-981-16-4787-1
    DOI: 10.1007/978-981-16-4787-1
    DDC: 615
    Sprache: Englisch
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  • 50
    Online-Ressource
    Online-Ressource
    A Roadmap to Successful Scientific Publishing : The Dos, the Don’ts and the Must-Knows (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical sciences. ; Vocational guidance. ; Career education. ; Biomedical Research. ; Health Sciences. ; Career Counseling. ; Career Skills.
    Beschreibung / Inhaltsverzeichnis: Part 1: Getting started -- Chapter 1: The why and the what of scientific research and publishing -- Chapter 2: Understanding research ethics -- Chapter 3: How to structure a scientific article, conference poster and presentation -- Part 2: The Hidden Bumps -- Chapter 4: Who gets authorship status? -- Chapter 5: The art of journal selection -- Chapter 6: Understanding the editor’s perspectives -- Part 3: The Destination -- Chapter 7: Converting a scientific article for the media -- Chapter 8: What are research metrics and why should I care? -- Chapter 9: Beyond your scientific publication -- Chapter 10: The Editor’s Perspective – Full-Length Interviews.
    Kurzfassung: In the age of "publish or perish," this book provides everything one needs to know about conducting research and successfully publishing it in a scientific journal. The reader learns about the complete process of scientific publishing: from selecting the most appropriate research design, to obtaining permissions and funding, to resourcefully presenting the research results in a poster and oral presentation. Additionally, the practical tips provided here help the reader formulate a compelling scientific article and choose the most suitable journal (subscription vs. the various open access modalities) for their publication. This book also addresses "invisible aspects" of scholarly publishing that are nonetheless important and that everyone should know and understand: avoiding predatory journals, understanding the editor's perspective, and becoming familiar with the various research metrics (from author to journal) that can all determine success or failure of a publication. Written in an informal style in which the author shares personal perspectives and experiences, the book is easily accessible to the reader. The book offers early career scientists in biomedicine and medicine a unique perspective on publishing research articles and how this process can enhance the authors' "scientific value" within the scientific ecosystem as well as their personal CVs.
    Materialart: Online-Ressource
    Seiten: XIV, 119 p. 25 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030992958
    URL: https://doi.org/10.1007/978-3-030-99295-8
    DOI: 10.1007/978-3-030-99295-8
    DDC: 610.72
    Sprache: Englisch
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  • 51
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    Online-Ressource
    Integrative Clinical Research (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Pain medicine. ; Artificial intelligence. ; Biomedical Research. ; Pain Medicine. ; Artificial Intelligence.
    Beschreibung / Inhaltsverzeichnis: Artificial Intelligence and Precision Medicine: A Perspective -- Pedobarography in Physiotherapy: A Narrative Review on Current Knowledge -- Quantum Medicine: A Role of Extremely Low-Frequency Magnetic Fields in the Management of Chronic Pain -- Manual Therapy Approach to the Extraocular Muscles in Migraine Treatment: A Preliminary Study -- Capacitive and Resistive Electric Transfer Therapy: A Comparison of Operating Methods in Non-specific Chronic Low Back Pain -- Serum Impedance in Children with Recurrent Respiratory Infections -- Olfactory Response to Altitude Hypoxia: A Pilot Study During a Himalayan Trek -- The Impact of Change in Hospital Admissions When Primary Care Is Provided by a Single Primary Care Physician: A Cohort Study Among HMO Patients in Israel -- Risk of Falls in Patients Aged Over 65 in the Context of the Treatment Facility -- Anthropometric Indices as Long-Term Predictors of Diabetes in Impaired Fasting Glucose Metabolism: Findings in the PURE Study in Poland -- Cardiovascular Risk Factors Drive Impaired Fasting Glucose to Type 2 Diabetes: Findings After a 9-Year Follow-Up in the PURE Study in Poland -- Sleep-Disordered Breathing in Pregnancy.
    Kurzfassung: This book embraces a comprehensive range of research across several disciplines, providing insights and fresh perspectives on clinical topics, emphasizing the integrative medical approach. The book also addresses an increasing role of artificial intelligence in the development of clinical methodologies, research, and patient-oriented care. The authors share expertise and experience in rehabilitation medicine whose healing-effects particularly depend on the interaction between the therapist and patient. Chapters present novel approaches in manual rehabilitative therapy of common painful and disabling neuromuscular ailments, exemplified but not limited to low back pain and migraine. The myofascial trigger point release therapy includes specific manipulations to muscles and connective tissue which reduce pain. Other chapters address the issues of providing long-range medical care to older adults burdened with chronic diseases, notably hypoxia-related pathologies and their sequalae, pointing to the advantages of care provided by a single primary care physician. Changing paradigm of care is essential in chronic atherosclerosis-based diseases like cardiovascular disorders or diabetes. Chapters provide results of international cohort studies on predictive factors for the long-range progress of such ailments based on anthropometric and lifestyle indicators. The book aims to meet the increasing interest and importance to patients of integrative health therapies. Medical rehabilitation and lifestyle changes increasingly gain scientific support in difficult-to-treat chronic conditions and should be integrated in a controlled manner into conventional medicine. The book is addressed to physiotherapists, medical scientists and clinicians, and allied healthcare professionals.
    Materialart: Online-Ressource
    Seiten: VI, 109 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030996307
    Serie: Clinical and Experimental Biomedicine, 1375
    URL: https://doi.org/10.1007/978-3-030-99630-7
    DOI: 10.1007/978-3-030-99630-7
    DDC: 610.72
    Sprache: Englisch
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  • 52
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    Online-Ressource
    Biomedical Visualisation : Volume 11 (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Education Data processing. ; Image processing Digital techniques. ; Computer vision. ; Anatomy. ; Biomedical engineering. ; Computer simulation. ; Biomedical Research. ; Computers and Education. ; Computer Imaging, Vision, Pattern Recognition and Graphics. ; Anatomy. ; Biomedical Engineering and Bioengineering. ; Computer Modelling.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Creating Interactive Three-Dimensional Applications to Visualise Novel Stent Grafts That Aid in the Treatment of Aortic Aneurysms -- Chapter 2. Using Confocal Microscopy to Generate an Accurate Vascular Model for Use in Patient Education Animation -- Chapter 3. Methods and applications of 3D Patient-Specific Virtual Reconstructions in Surgery -- Chapter 4. Proof of Concept for the Use of Immersive Virtual Reality in Upper Limb Rehabilitation of Multiple Sclerosis Patients -- Chapter 5. Virtual Wards: A Rapid Adaptation to Clinical Attachments in MBChB During the COVID-19 Pandemic -- Chapter 6. Artificial Intelligence: Innovation to Assist in the Identification of Sono-anatomy for Ultrasound-Guided Regional Anaesthesia -- Chapter 7. A Systematic Review of Randomised Control Trials Evaluating the Efficacy and Safety of Open and Endoscopic Carpal Tunnel Release -- Chapter 8. Exploring Visualisation for Embryology Education: A Twenty-First-Century Perspective -- Chapter 9. How Artificial Intelligence and Machine Learning Is Assisting Us to Extract Meaning from Data on Bone Mechanics? -- Chapter 10. Visual Communication and Creative Processes Within the Primary Care Consultation -- Chapter 11. Digital 2D, 2.5D and 3D Methods for Adding Photo-Realistic Textures to 3D Facial Depictions of People from the Past -- Chapter 12. Teaching with Cadavers Outside of the Dissection Room Using Cadaveric Videos -- Chapter 13. A Novel Cadaveric Embalming Technique for Enhancing Visualisation of Human Anatomy -- Chapter 14. Assessing the Impact of Interactive Educational Videos and Screencasts Within Pre-clinical Microanatomy and Medical Physiology Teaching.
    Kurzfassung: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The chapters presented in this volume cover such a diverse range of topics, with something for everyone. We present here chapters on 3D visualising novel stent grafts to aid treatment of aortic aneuryms; confocal microscopy constructed vascular models in patient education; 3D patient specific virtual reconstructions in surgery; virtual reality in upper limb rehabilitation in patients with multiple sclerosis and virtual clinical wards. In addition, we present chapters in artificial intelligence in ultrasound guided regional anaesthesia; carpal tunnel release visualisation techniques; visualising for embryology education and artificial intelligence data on bone mechanics. Finally we conclude with chapters on visualising patient communication in a general practice setting; digital facial depictions of people from the past; instructor made cadaveric videos, novel cadaveric techniques for enhancing visualisation of the human body and finally interactive educational videos and screencasts. This book explores the use of technologies from a range of fields to provide engaging and meaningful visual representations of the biomedical sciences. It is therefore an interesting read for researchers, developers and educators who want to learn how visualisation techniques can be used successfully for a variety of purposes, such as educating students or training staff, interacting with patients and biomedical procedures in general.
    Materialart: Online-Ressource
    Seiten: XVI, 343 p. 163 illus., 153 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030877798
    Serie: Advances in Experimental Medicine and Biology, 1356
    URL: https://doi.org/10.1007/978-3-030-87779-8
    DOI: 10.1007/978-3-030-87779-8
    DDC: 610.72
    Sprache: Englisch
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    Nanoscale Engineering of Biomaterials: Properties and Applications (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Proteins. ; Biomaterials. ; Nanomedicine. ; Biomedical engineering. ; Biomedical Research. ; Biomaterials-Proteins. ; Nanomedicine and Nanotoxicology. ; Biomedical Engineering and Bioengineering.
    Beschreibung / Inhaltsverzeichnis: Part 1 -- 1 Interactions between the physiological environment and titanium-based implant materials – from understanding to control -- 2 Nanoscale surface Engineering and Characterization of Biomaterial -- 3 Progress of Nanotechnology-based Detection and Treatment of Alzheimer’s Disease Biomarkers -- 4 Biomaterials: Types and Applications -- Part 2 -- 5 Additive Manufacturing of Ti and its alloy-based Bioimplants for Orthopaedic Applications -- 6 Physico-chemical Modifications of Magnesium and Alloys for Biomedical Applications -- 7 Metallic Foams in Bone Tissue Engineering -- 8 Surface modification of metallic biomaterials for cardiovascular cells regulation and biocompatibility improvement -- 9 Advancement of spinel ferrites for biomedical application -- Part 3 -- 10 Functionalized 3D bioactive polymeric materials in tissue engineering and regenerative medicine -- 11 Polymer matrixes used in wound healing applications. 12 Conductive Polymers for Cardiovascular Applications -- 13 Engineered polymeric materials/nanomaterials for growth factor/drug delivery in bone tissue engineering applications -- 14 Surface engineering of polymeric materials for bone tissue engineering -- 15 Antibacterial Surface Modification to Prevent Biofilm Formation on Polymeric Biomaterials -- 16 Polymer Surface Engineering in the Food Packaging Industry -- 17 Polymeric Membranes in Waste-water Treatment -- 18 Functionalized Fluoropolymer Membrane for Fuel Cell Applications -- Part 4 -- 19 Bioceramics for Biomedical Applications -- 20 Applications of nanomaterials in the textile industry -- 21 Properties and characterization of advanced composite materials -- 22 Properties and characterization of advanced composite materials -- 23 Nano composites application in sewage treatment and degradation of persistent pesticides used in agriculture -- 24 Biomimetic Mineralization of Electrospun PCL based Composite Nanofibrous Scaffold for hard tissue Engineering. .
    Kurzfassung: This book provides a comprehensive overview of the latest advances in a wide range of biomaterials for the development of smart and advanced functional materials. It discusses the fundamentals of bio-interfacial interactions and the surface engineering of emerging biomaterials like metals and alloys, polymers, ceramics, and composites/nanocomposites. In turn, the book addresses the latest techniques and approaches to engineering material surfaces/interfaces in, e.g., implants, tissue engineering, drug delivery, antifouling, and dentistry. Lastly, it summarizes various challenges in the design and development of novel biomaterials. Given its scope, it offers a valuable source of information for students, academics, physicians and particularly researchers from diverse disciplines such as material science and engineering, polymer engineering, biotechnology, bioengineering, chemistry, chemical engineering, nanotechnology, and biomedical engineering for various commercial and scientific applications.
    Materialart: Online-Ressource
    Seiten: X, 704 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811636677
    URL: https://doi.org/10.1007/978-981-16-3667-7
    DOI: 10.1007/978-981-16-3667-7
    DDC: 610.72
    Sprache: Englisch
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  • 54
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    Online-Ressource
    Novel Drug Targets With Traditional Herbal Medicines : Scientific and Clinical Evidence (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Pharmacology. ; Toxicology. ; Pharmaceutical chemistry. ; Medicinal chemistry. ; Natural products. ; Pharmacology. ; Toxicology. ; Pharmaceutics. ; Medicinal Chemistry. ; Natural Products.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Achillea biebersteinii Afan -- Chapter 2: Aesculus hippocastanum L. -- Chapter 3: Berberis crataegina DC. -- Chapter 4: Calendula officinalis L. -- Chapter 5: Camellia sinensis (L.) Kuntze -- Chapter 6: Capsella bursa-pastoris (L.) Medik. -- Chapter 7: Capsicum annuum L. -- Chapter 8: Cedrus libani A.Rich. -- Chapter 9: Chelidonium majus L. -- Chapter 10: Cichorium intybus L. -- Chapter 11: Cistus laurifolius L. -- Chapter 12: Coriandrum sativum L. -- Chapter 13: Cornus mas L. -- Chapter 14: Curcuma longa L..-Chapter 15: Cydonia oblonga Mill. -- Chapter 16: Cynara scolymus L. -- Chapter 17: Equisetum arvense L. -- Chapter 18: Foeniculum vulgare Mill. -- Chapter 19: Fraxiınus ornus L. -- Chapter 20: Fumaria officinalis L. -- Chapter 21: Helichrysum plicatum DC. -- Chapter 22: Hyoscyamus niger L. -- Chapter 23: Juglans regia L. -- Chapter 24: Laurus nobilis L. -- Chapter 25: Liquidambar orientalis Miller -- Chapter 26: Matricaria chamomilla L. -- Chapter 27: Melissa officinalis L. -- Chapter 28: Momordica charantia L. -- Chapter 29: Nigella sativa L. -- Chapter 30: Olea europaea L. -- Chapter 31: Papaver somniferum L. -- Chapter 32: Rheum ribes L. -- Chapter 33: Rosa canina L. -- Chapter 34: Rosmarinus officinalis L. -- Chapter 35: Silybum marianum L. Gaertn. -- Chapter 36: Urtica dioica L -- Chapter 37: Valeriana officinalis L. -- Chapter 38: Viburnum opulus L.
    Kurzfassung: This book collects information about the most popular ethnomedicinal plants, which are common in Turkey and around the world. It presents the ethnopharmacological records, in vivo and in vitro studies, side effects, chemical compositions and clinical studies of these medicinal plants. Its special focus is on the novel drug targets for disease and their possible mechanisms of action. It covers botanical descriptions the status of the plants, and food or drug interactions including precautions and warnings about the plants and the available market products. It provides an explanation of recorded and known plant administration dosages. Also, the gap between the traditional practice and scientific/clinical evidences in the use of ethnomedicinal plant is acknowledged. It is well known that traditional knowledge of the use of the medicinal plants in therapy is an important resource for the discovery of novel treatment options and drug targets. The main purpose of this book is to draw attention to ethnomedicinal plant species. Data on the therapeutic potentials of these medicinal plants can now be accessed from a single source. It provides an important resource for future research opportunities for harnessing the full potential of these plants.
    Materialart: Online-Ressource
    Seiten: XII, 588 p. 119 illus., 43 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031077531
    URL: https://doi.org/10.1007/978-3-031-07753-1
    DOI: 10.1007/978-3-031-07753-1
    DDC: 615
    Sprache: Englisch
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  • 55
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    Online-Ressource
    Trends of Artificial Intelligence and Big Data for E-Health (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical care. ; Quantitative research. ; Artificial intelligence Data processing. ; Health services administration. ; Bioinformatics. ; Biomedical Research. ; Health Care. ; Data Analysis and Big Data. ; Data Science. ; Health Care Management. ; Bioinformatics.
    Beschreibung / Inhaltsverzeichnis: 1. AI and Big Data for Intelligent Health: Promise and Potential -- 2. AI and Big Data for Cancer Segmentation, Detection and Prevention -- 3. Radiology, AI and Big Data: Challenges and Opportunities for Medical Imaging -- 4. Neuroradiology: Current Status and Future Prospects -- 5. Big Data and AI in Cardiac Imaging -- 6. Artificial Intelligence and Big data for COVID-19 Diagnosis -- 7. AI and Big Data for Drug Discovery -- 8. Blockchain of IoMT (BIoMT): A New Paradigm for COVID-19 Pandemic: Application, Architecture, Technology, and Security -- 9. AI and Big Data for Therapeutic Strategies in Psychiatry -- 10. Distributed Learning in Healthcare -- 11. Cybersecurity in Healthcare -- 12. Radiology and Radiomics: Towards oncology Prediction with IA and Big Data.
    Kurzfassung: This book aims to present the impact of Artificial Intelligence (AI) and Big Data in healthcare for medical decision making and data analysis in myriad fields including Radiology, Radiomics, Radiogenomics, Oncology, Pharmacology, COVID-19 prognosis, Cardiac imaging, Neuroradiology, Psychiatry and others. This will include topics such as Artificial Intelligence of Thing (AIOT), Explainable Artificial Intelligence (XAI), Distributed learning, Blockchain of Internet of Things (BIOT), Cybersecurity, and Internet of (Medical) Things (IoTs). Healthcare providers will learn how to leverage Big Data analytics and AI as methodology for accurate analysis based on their clinical data repositories and clinical decision support. The capacity to recognize patterns and transform large amounts of data into usable information for precision medicine assists healthcare professionals in achieving these objectives. Intelligent Health has the potential to monitor patients at risk with underlying conditions and track their progress during therapy. Some of the greatest challenges in using these technologies are based on legal and ethical concerns of using medical data and adequately representing and servicing disparate patient populations. One major potential benefit of this technology is to make health systems more sustainable and standardized. Privacy and data security, establishing protocols, appropriate governance, and improving technologies will be among the crucial priorities for Digital Transformation in Healthcare.
    Materialart: Online-Ressource
    Seiten: X, 251 p. 67 illus., 64 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031111990
    Serie: Integrated Science, 9
    URL: https://doi.org/10.1007/978-3-031-11199-0
    DOI: 10.1007/978-3-031-11199-0
    DDC: 610.72
    Sprache: Englisch
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  • 56
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    Online-Ressource
    Engineering Biomaterials for Neural Applications (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Biomedical engineering. ; Neurosciences. ; Biotechnology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Biomedical Devices and Instrumentation. ; Neuroscience. ; Biotechnology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Scaffolds for promoting neural repair -- Chapter 2. Composites for nerve regeneration -- Chapter 3. Configurable models of the blood-brain barrier -- Chapter 4. Engineering nerve conduits -- Chapter 5. Flexible electronics for stem cell differentiation -- Chapter 6. Nanosensors for brain chemistry -- Chapter 7. Nanomaterials for imaging the brain ECS -- Chapter 8. Microfluidics for analysis of neuronal development -- Chapter 9. Multiple particle tracking measurements of extracellular matrix dysregulation -- Chapter 10. Bioresponsive nanomaterials for treatment of CNS disease -- Chapter 11. Redox regulation for controlling cell fate -- Chapter 12. Polymersome delivery of CRISPR-based therapies -- Chapter 13. Multifunctional polymers for targeted delivery -- Chapter 14. Theranostic nanomaterials for brain injury.
    Kurzfassung: This contributed volume explores the ways in which researchers engineer new biomaterials for the challenging problems of the peripheral and central nervous systems. These biomaterials are uniquely positioned for use in creating in vitro models of injury and disease, testing therapeutic treatments, understanding neural development, and mapping the multi-scalar environment of the brain. This book informs readers from biology, chemistry, materials science, engineering, and neuroscience on cutting edge research in engineering technologies, from fundamental material development through pre-clinical studies. The book also highlights target applications in three areas of research: (1) engineering neural models and materials, (2) probing biological underpinnings of neurological function and disease, and (3) designing therapeutic and diagnostic treatments for neurological disease. .
    Materialart: Online-Ressource
    Seiten: VIII, 353 p. 64 illus., 61 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031114090
    URL: https://doi.org/10.1007/978-3-031-11409-0
    DOI: 10.1007/978-3-031-11409-0
    DDC: 610.72
    Sprache: Englisch
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  • 57
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    Flow Cytometry Today : Everything You Need to Know about Flow Cytometry (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Cytology. ; Biology Technique. ; Medicine Research. ; Biology Research. ; Cell Biology. ; Biological Techniques. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. General Principles -- Chapter 2. Signals – Scattering -- Chapter 3. Signals - Fluorescence, Phosphorescence, Impedance, Extinction -- Chapter 4. Fluidics -- Chapter 5. Light Sources -- Chapter 6. Optical Benches -- Chapter 7. Detectors and Electronics -- Chapter 8. Signal Analysis -- Chapter 9. The Cytometric File -- Chapter 10. Data Transformation -- Chapter 11. Data Representation -- Chapter 12. Data Analysis -- Chapter 13. Standards, Setup, Calibration, and Control Techniques -- Chapter 14. Fluorochromes – Overview -- Chapter 15. Fluorochromes Suitable for Antibody Conjugation -- Chapter 16. Fluorochromes That Bind Nucleic Acids -- Chapter 17. Fluorochromes for the Study of the Cell Features -- Chapter 18. Fluorescent Proteins -- Chapter 19. Spillover and Compensation -- Chapter 20. Artifacts -- Chapter 21. Cell Sorting -- Chapter 22. Non-Conventional Flow Cytometry -- Chapter 23. Statistics: A Cytometric Point of View.
    Kurzfassung: This book covers all the technical aspects of flow cytometry needed to set-up the instrument, solve problems encountered in daily work, or necessary for exam preparation. It provides the reader with an in-depth look at the device and its applications. Each component and its function is described in an easy-to-understand manner, giving the reader a sound basic knowledge of this instrument. The practical examples given, simplify and enhance the learning process. This book is a unique resource of knowledge for biomedical engineers and biotechnologists, flow cytometry operators, laboratory technicians and biomedical researchers, both biologists as well as medical doctors, and can also be a helpful tool for companies and manufacturers.
    Materialart: Online-Ressource
    Seiten: XXIX, 544 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031108365
    URL: https://doi.org/10.1007/978-3-031-10836-5
    DOI: 10.1007/978-3-031-10836-5
    DDC: 571.6
    Sprache: Englisch
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  • 58
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    Principles of Light Microscopy: From Basic to Advanced (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Life sciences. ; Cytology. ; Spectrum analysis. ; Biomedical Research. ; Life Sciences. ; Cell Biology. ; Spectroscopy.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. The physical principles of light propagation and light-matter interactions -- Chapter 2. Design, alignment and usage of infinity-corrected microscope -- Chapter 3. Epifluorescence Microscopy -- Chapter 4. Basic digital image design, processing, analysis, management, and presentation -- Chapter 5. Confocal Microscopy -- Chapter 6. Live-cell Imaging: A Balancing Act Between Speed, Sensitivity and Resolution -- Chapter 7. Structured Illumination Microscopy -- Chapter 8. Stimulated Emission Depletion Microscopy -- Chapter 9. Two-Photon Imaging -- Chapter 10. Modern microscopy image analysis: quantifying colocalization on a mobile device -- Chapter 11. Spinning Disk Microscopy -- Chapter 12. Light Sheet Fluorescence Microscopy -- Chapter 13. Localization microscopy: a review of the progress in methods and applications.
    Kurzfassung: This textbook is an excellent guide to microscopy for students and scientists, who use microscopy as one of their primary research and analysis tool in the laboratory. The book covers key microscopy principles and explains the various techniques such as epifluorescence microscopy, confocal/live cell imaging, SIM/light sheet microscopy, and many more. Easy-to-understand protocols provide helpful guidance for practical implementation in various commercially available imaging systems. The reader is introduced to histology and further be guided through advanced image acquisition, classification and analysis. The book is written by experienced imaging specialists from the UK, other EU countries, the US and Asia, and is based on advanced training courses for master students and PhD students. Readers are not expected to be familiar with imaging and microscopy technologies, but are introduced to the subject step by step. This textbook is indented for biomedical and medical students, as well as scientists and postdocs who want to acquire a thorough knowledge of microscopy, or gain a comprehensive overview of modern microscopy techniques used in various research laboratories and imaging facilities. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Materialart: Online-Ressource
    Seiten: VIII, 324 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031044779
    URL: https://doi.org/10.1007/978-3-031-04477-9
    DOI: 10.1007/978-3-031-04477-9
    DDC: 610.72
    Sprache: Englisch
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  • 59
    Online-Ressource
    Online-Ressource
    Immunomodulators and Human Health (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Immunology. ; Biotechnology. ; Medicine Research. ; Biology Research. ; Immune system. ; Cellular signal transduction. ; Immunotherapy. ; Immunology. ; Biotechnology. ; Biomedical Research. ; Immune Cell Signalling. ; Immunotherapy. ; Applied Immunology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Classification, Mode of Action and Uses of Various Immunomodulators -- Chapter 2. Potential role of herbs and spices on the immune system -- Chapter 3. Immune booster activity of Prebiotics -- Chapter 4. Antioxidants and Immunomodulation -- Chapter 5. Nanotechnology and Immunomodulators in Cancer -- Chapter 6. Advancements in the field of Oral, Intravenous and Inhaled Immunomodulators using Nanotechnology -- Chapter 7. Phytochemicals as the source of Natural Immunomodulator & their role in Cancer Chemoprevention -- Chapter 8. Immunomodulators and Autoimmune Liver Diseases -- Chapter 9. Immunomodulatory role for the treatment and management of tuberculosis -- Chapter 10. Immunomodulation in Autoimmune Disorders -- Chapter 11. Psychology, Epigenetics, Immunomodulation and Immune Dysfunction: Understanding the Connection -- Chapter 12. Herbal Immunomodulators and COVID-19 -- Chapter 13. Role of Cytokines as Immunomodulators -- Chapter 14. Immunomodulatory properties of proteins and peptides: Food derivates approach -- Chapter 15. Fatty Acids and Immunomodulation -- Chapter 16. Immunomodulatory Effects of Endocrine Disrupting Chemicals.-.
    Kurzfassung: This book focuses on a broad range of immunomodulators, including both natural and synthetic ones. It highlights their role in human health. The book discusses nanotechnology-based immunomodulators with special emphasis on different types of formulation to boost the immune system. It highlights the role of immunomodulators against different microbes. This book describes important topics such as Classification and uses of various immunomodulators; Potential role of herbs and spices on immune system; Immune booster activity of prebiotics; Recent advances of nutraceutical and functional foods in Immune health; Antioxidants and immunomodulation; Nanotechnology and immunomodulators in cancer; Immunomodulatory role for the treatment and management of tuberculosis; Immunomodulation in autoimmune disorders; Herbal immunomodulators and COVID-19; Role of Cytokines as Immunomodulators and Immunomodulatory effects of endocrine disrupting chemicals. This book covers various aspects of product innovation, development, and launching of nutritional and pharmaceutical products with reference to immunomodulators. This book is meant for researchers and students in the field of immunology and pharmaceutical sciences.
    Materialart: Online-Ressource
    Seiten: XVIII, 509 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811663796
    URL: https://doi.org/10.1007/978-981-16-6379-6
    DOI: 10.1007/978-981-16-6379-6
    DDC: 571.96
    Sprache: Englisch
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  • 60
    Online-Ressource
    Online-Ressource
    Zebrafish Model for Biomedical Research (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Pharmaceutical chemistry. ; Medical genetics. ; Pharmaceutics. ; Medical Genetics. ; Medical Genetics.
    Beschreibung / Inhaltsverzeichnis: 1 ABCD of Zebrafish Culture -- 2 Zebrafish: a model organism to understand tumor angiogenesis mechanism -- 3 Zebrafish as a xenotransplantation model for studying cancer biology and cancer drug discovery -- 4 Zebrafish Models for Screening of Metabolic diseases -- 5 Role of Zebrafish as an experimental model for renal disorders -- 6 Evolution of Zebrafish As A Novel Pharmacological Model in Endocrine Research -- 7 Zebrafish as a versatile model for cancer research -- 8 Zebrafish as an Indispensable tool for Infectious diseases & Immune modulatory studies -- 9 Common models for cancer research -- 10 Zebrafish model for biomedical research -- 11 Zebrafish Model for Biomedical Research: Creating Waves in Ocean of Evidence -- 12 Zebrafish as a novel pharmacological screening model for drug discovery and development against hematological disorders -- 13 Zebrafish-a Metamorphosis in Ophthalmological Research: A Literature Review -- 14 Zebrafish: A potential preclinical model for neurological research in modern biology -- 15 Zebrafish Screening for Skin Diseases -- 16 Growing importance of Zebrafish in translational neuroscience -- 17 Supporting the next generation of risk assessment in toxicology: the design of AOPs anchored on the alternative model zebrafish -- 18 Zebrafish: a novel model in Psychopharmacological research -- 19 Pharmacological modeling of gastrointestinal disorders in zebrafish for drug discovery and development -- 20 Zebra Fish Models for Liver Diseases -- 21 Zebrafish Model for Neurotoxic Drug Screening: Methodologies and Protocols. .
    Kurzfassung: This book provides the latest information on the significance of zebrafish as an ideal model for researching the biomedical field, with references. This book also focused on the evidence of zebrafish as a model in cardiovascular, neurologic, psychiatric and metabolic research. In addition, the book also includes the research carried out on zebrafish in hepatic, renal, ophthalmic, and ENT related areas. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish models including specific research in the area of skin disorders, endocrine diseases, nutritional disorders, gastrointestinal, hematological disorders and cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and its suitability for modeling various diseases, providing a critical resource on the potential attributes of the zebrafish as a pharmacological model. In terms of scope, this book is a useful tool for young researchers, professors and pharmaceutical scientists for understanding the significance of zebrafish as an emerging pharmacological model that can significantly aid in the process of drug discovery and development.
    Materialart: Online-Ressource
    Seiten: XV, 490 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811652172
    URL: https://doi.org/10.1007/978-981-16-5217-2
    DOI: 10.1007/978-981-16-5217-2
    DDC: 615.19
    Sprache: Englisch
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  • 61
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    Online-Ressource
    Fundamentals and Advances in Medical Biotechnology (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Biomedical engineering. ; Biotechnology. ; Molecular biology. ; Nanotechnology. ; Bioethics. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Molecular Biology. ; Nanotechnology. ; Bioethics.
    Beschreibung / Inhaltsverzeichnis: The advent of Medical Biotechnology -- Biotechnology in Medicine: Fundamentals -- Biotechnology in Medicine: Advances-I -- Biotechnology in Medicine: Advances-II -- Analytical Techniques in Medical Biotechnology -- Immunology in Medical Biotechnology -- Epigenetics and Medical Biotechnology -- Stem Cell Technology in Medical Biotechnology -- Pharmaceutical Biotechnology -- Diagnostic and Therapeutic Biotechnology -- Nanotechnology and Nanomedicine -- Laboratory Protocols in Medical Biotechnology-I -- Laboratory Protocols in Medical Biotechnology-II -- Ethics and Medical Biotechnology -- Career and opportunities in Medical Biotechnology -- Index.
    Kurzfassung: This book serves as an introduction to the concepts of medical biotechnology, with great details about fundamentals and early disciplines of study as well as emerging fields and the latest research. The book follows a chronological order from the earliest discoveries and breakthroughs of medical biotechnology to the latest areas of study. The book contains up-to-date citations for each chapter and section, which makes it easy for the reader to understand the concept and also to follow the latest developments in the particular area. It is an ideal book for undergraduate and graduate students who aspire to derive basic knowledge and are also keen on learning about the latest advancements in the field of medical biotechnology. .
    Materialart: Online-Ressource
    Seiten: XII, 459 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030985547
    URL: https://doi.org/10.1007/978-3-030-98554-7
    DOI: 10.1007/978-3-030-98554-7
    DDC: 610.72
    Sprache: Englisch
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  • 62
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    Online-Ressource
    Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Drug delivery systems. ; Medicinal chemistry. ; Pharmaceutical chemistry. ; Pharmacology. ; Drug Delivery. ; Medicinal Chemistry. ; Pharmaceutics. ; Pharmacology.
    Beschreibung / Inhaltsverzeichnis: Part 1-Modelling of PK/PD for NPDDS -- Introduction to Nanoparticulate Drug Delivery Systems -- Nanoparticle Properties Affecting Pharmacokinetics of NPDDS -- Models Used for Biopharmaceutical Evaluation of NPDDS -- Models Used in the Pharmacokinetic Evaluation of NPDDS -- Models Used in the Pharmacodynamic Evaluation of NPDDS -- Preclinical Animal Models For Experimental Design of Pharmacokinetic Studies of NPDDS -- Pharmacokinetic Modelling Program (PKMP) -- Part 2-PK/PD for Specific Nanocarriers -- Pharmacokinetic and Pharmacodynamics of Liposomal Nanoparticles -- Pharmacokinetics of Polymer Matrix Drugs (NPDDS) -- Pharmacokinetics of Long-Circulating NPDDS -- Metallic Gold Nanoparticles in vivo Pharmacokinetics and X-ray Contrast imaging Studies -- Muco-adhesive NPDDS In Vitro and Pharmacokinetics Studies -- Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles -- Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles -- PKPD of PLGA-PEG-PLGA Triblock CoPolymeric Micelles -- Part 3-PKPD in Diseased Conditions for NPDDS -- Bridging Bio-Nanoscience and Cancer Nanomedicine -- Clearance Pathways and Tumor Targeting of Imaging Nanoparticles for Diagnostics -- PLGA Nanoparticles for Oral Delivery-Nephrotoxicity and Pharmacokinetic Studies -- Pharmacokinetics of Nanoparticle Systems for Pulmonary Delivery -- In vivo Biodistribution and Pharmacokinetic Studies of NPDDS for Brain Targeting -- Enhanced Bioavailability and Intestinal Uptake Nanoparticles After Oral Delivery -- Nanoparticle Pharmacokinetic Profiling In Vivo Using Magnetic Resonance Imaging.
    Kurzfassung: A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.
    Materialart: Online-Ressource
    Seiten: XIII, 438 p. 102 illus., 84 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030833954
    URL: https://doi.org/10.1007/978-3-030-83395-4
    DOI: 10.1007/978-3-030-83395-4
    DDC: 615.6
    Sprache: Englisch
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  • 63
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    Online-Ressource
    Multidisciplinarity and Interdisciplinarity in Health (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Neurosciences. ; Public health. ; Bioethics. ; Clinical medicine Research. ; Biomedical Research. ; Neuroscience. ; Public Health. ; Bioethics. ; Clinical Research.
    Beschreibung / Inhaltsverzeichnis: Introduction on Integrated Science: Multidisciplinarity and Interdisciplinarity in Health -- Cognitive Sciences as a Naturalistic Model of Interdisciplinary Approaches -- The Aesthetics of Science from the Viewpoint of Neuroscience -- Neuroscience and Quantum Physics Aspect of Human Brainwaves -- Modern Psychiatry: Confluence of Mind, Science, and Society -- Schizophrenia: A Disorder of Timing and Sensorimotor Integration during Decision-making -- Getting to Know Ourselves Through Recognizing Ourselves in Others: Neuroanatomy of Empathy in a Social Neuroscientific Model -- Why People Make Irrational Choices About Their Health? -- Adherence to Treatment: At the Interface of Biological, Medical, and Social Sciences -- Social Cognition and Food Decisions in Obesity -- Nuclear Medicine: A Transdisciplinary Field to Integrate Formal, Physical, Biological, and Medical Sciences -- Beyond the Borders of Dentistry: Interprofessional and Interdisciplinary Approach to Oral Health Promotion -- Drug Discovery in Big Pharma: Where “Birds” and “Fish” Collaborate to Find New Medicines -- A Phenomenological Analysis of the Pandemic: Philosophy and Life -- Engineering, Environment, and Health: Why interdisciplinarity matters? -- Super-spreading in Infectious Diseases: A Global Challenge for All Disciplines -- Possibility of Changes in Travel Behavior as a Consequence of the Pandemic and Teleworking -- Bringing the Two Cultures of the Arts and Sciences Together in Complex Health Interventions -- Thinking Deeper, Wider, Further: Visual Thinking for the Pandemic 3.0 and the Game-Changing Pathways ahead -- The Clinical Benefits of Art Therapy: Definition, History, and Outcomes with a Focus on Music Therapy -- When Combining Arts and Sciences Assists Medical Devices Uses: DeafSpace and Cochlear Implants -- Art, Medicine, and Public Health: Synergizing Humanistic and Medical Strategies in Managing a Pandemic -- Big Data and Artificial Intelligence for E-Health -- Artificial Intelligence in the Medical Context: Who Is the Agent in Charge? -- Ethical Deliberation on AI-Based Medicine -- Towards an Integrative and Holistic Approach to the Discipline of Health Informatics -- Integrated, Multidisciplinary, and Interdisciplinary Medical Education -- Giving Voice to Social Values in Achieving Universal Health Coverage -- Discrimination in Medical Research Sampling: Recommendations and Applications to Psychology -- Integrated Science 2050: Multidisciplinarity and Interdisciplinarity in Health.
    Kurzfassung: The contributed volume "Multidisciplinarity and Interdisciplinarity in Health" is a health-centered volume of the Integrated Science Book series. Lack of confidence, lack of expertise, complexities of healthcare, the confusing nature of healthcare environments, and lack of organization and standardization can become obstacles to successful communication. This volume establishes how extensive is the interface between formal sciences and medical sciences on health-related issues. The book provides an overview of the value of the integration of formal, biological, and medical sciences and related products, i.e., health informatics and biomedical engineering, to frame a holistic approach to health systems, healthcare, medical practice, drug discovery, and medical device design. The book also focuses on innovative solutions to the most critical issues of different health crisis, including obesity, infectious outbreaks, and cancer that can be found by using an integrative approach. It also contains the fascinating crossroads between medical sciences, physics, and mind that is discussed from multiple perspectives on cognition, neuroscience, and psychiatry. These multidisciplinary considerations will expand the concepts of creativity, leadership, aesthetics, empathy and mental health. .
    Materialart: Online-Ressource
    Seiten: XVI, 729 p. 168 illus., 138 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030968144
    Serie: Integrated Science, 6
    URL: https://doi.org/10.1007/978-3-030-96814-4
    DOI: 10.1007/978-3-030-96814-4
    DDC: 610.72
    Sprache: Englisch
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  • 64
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    Bio-Nano Interface : Applications in Food, Healthcare and Sustainability (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Biotechnology. ; Nanotechnology. ; Medicine Research. ; Biology Research. ; Industrial microbiology. ; Pharmaceutical chemistry. ; Biotechnology. ; Nanotechnology. ; Biomedical Research. ; Industrial Microbiology. ; Pharmaceutics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1.Impact of isotropic and anisotropic plasmonic metal nanoparticles on healthcare and food-safety management -- Chapter 2. An introduction to different methods of nanoparticles synthesis -- Chapter 3. Classification, Synthesis, and Application of Nanoparticles against Infectious Diseases -- Chapter 4. Nanotechnology in Food Science -- Chapter 5. Facets of Nanotechnology in food processing, packaging and safety: an emerald insight -- Chapter 6. Nanotechnology and its potential application in postharvest technology -- Chapter 7. Nanotechnology mediated detection and control of phytopathogens -- Chapter 8. Nanosystems for Cancer Therapy -- Chapter 9. Phytoplankton mediated nanoparticles for cancer therapy. Chapter 10. Nanotechnology and its potential implications in Ovary Cancer -- Chapter 11. Nanotechnology: An Emerging Field in Protein Aggregation and Cancer Therapeutics -- Chapter 12. Bio-nano interface and its potential application in Alzheimer’s disease -- Chapter 13. Potential of curcumin nanoparticles in tuberculosis management -- Chapter 14. Application of Nanobiosensor in Health care sector -- Chapter 15. Bioactive nanoparticles: A next generation smart nanomaterials for pollution abatement and ecological sustainability -- Chapter 16. Smart nano-materials for bio-imaging applications:An overview -- Chapter 17. Biology of Earthworm in a World of Nano-materials: New Room, Challenges and, Future Perspectives -- Chapter 18. Bioethanol production from agricultural wastes with the aid of nanotechnology -- Chapter 19. Nanotechnology for sustainable bioenergy production.
    Kurzfassung: This book discusses the unique interactions of nanoparticles with various biomolecules under different environmental conditions. It describes the consequences of these interactions on other biological aspects like flora and fauna of the niche, cell proliferation, etc. The book provides information about the novel and eco-friendly nanoparticle synthesis methods, such as continuous synthesis of nanoparticles using microbial cells. Additionally, the book discusses nanoparticles' potential impact in different areas of biological sciences like food, medicine, agriculture, and the environment. Due to their advanced physicochemical properties, nanoparticles have revolutionized biomedical and pharmaceutical sciences. Inside the biological milieu, nanoparticles interact with different moieties to adopt stable shape, size, and surface functionalities and form nano-biomolecular complexes. The interaction pattern at the interface form complexes determines the fate of interacting biomolecules and nanoparticles inside the biological system. Understanding the interaction pattern at the nano-bio interface is crucial for the safe use of nanoparticles in natural sciences. This book rightly addresses all questions about the interaction and the ensuing structure and function of these nano-biomolecular complexes. This book caters to students and researchers in the area of biotechnology, microbiology, and pharmaceutical sciences.
    Materialart: Online-Ressource
    Seiten: IX, 355 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811625169
    URL: https://doi.org/10.1007/978-981-16-2516-9
    DOI: 10.1007/978-981-16-2516-9
    DDC: 660.6
    Sprache: Englisch
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  • 65
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    Online-Ressource
    Pharmacokinetics: Basics to Applications (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Internal medicine. ; Pharmaceutical chemistry. ; Biomathematics. ; Internal Medicine. ; Pharmaceutics. ; Mathematical and Computational Biology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Fundamentals of Pharmacokinetics -- Chapter 2: Drug absorption -- Chapter 3: The extent of drug absorption: bioavailability, clearance, bioequivalence, and protein-binding -- Chapter 4: Pharmacokinetic models and drug distribution -- Chapter 5: Drug metabolism -- Chapter 6: Drug elimination and nonlinear kinetics -- Chapter 7: Pharmacokinetic drug-drug interactions -- Chapter 8: Pharmacokinetic applications -- Chapter 9: Pharmacokinetic sample collection and processing -- Chapter 10: Important bio-analytical instrumental techniques in pharmacokinetics -- Chapter 11: Statistics in pharmacokinetics -- Chapter 12: Pharmacokinetic software and tools -- Chapter 13: Pharmacokinetic laboratory-based experiments -- Chapter 14: Pharmacokinetic numerical problems with solutions -- Chapter 15: Questions, and questions & answers for practice.
    Kurzfassung: This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.
    Materialart: Online-Ressource
    Seiten: XXXI, 334 p. 77 illus., 5 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811689505
    URL: https://doi.org/10.1007/978-981-16-8950-5
    DOI: 10.1007/978-981-16-8950-5
    DDC: 616
    Sprache: Englisch
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  • 66
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    Online-Ressource
    Green Nanoparticles: The Future of Nanobiotechnology (2022)
    Singapore :Springer Nature Singapore :
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    Schlagwort(e): Medicine Research. ; Biology Research. ; Zoology. ; Nanobiotechnology. ; Botany. ; Biomedical Research. ; Zoology. ; Nanobiotechnology. ; Plant Science.
    Beschreibung / Inhaltsverzeichnis: 1 Green nanotechnology: an overview -- 2 The Nano-Domain -- 3 Tools and Techniques Used in Nanobiotechnology -- 4 Green Synthesis of Nanoparticles -- 5 Biological Synthesis of Nanoparticles: Bacteria -- 6 Biological Synthesis of Nanoparticles: Fungi -- 7 Biological Synthesis of Nanoparticles: Algae -- 8 Biological Synthesis of Nanoparticles: Bryophytes -- 9 Biological synthesis of nanoparticles: Pteridophytes -- 10 Biological Synthesis of Nanoparticles: Gymnosperms -- 11 Biological Synthesis of Nanoparticles: Angiosperms- Monocotyledons -- 12 Biological Synthesis of Nanoparticles: Dicotyledons -- 13 Biological Synthesis of Nanoparticles: Animal Systems -- 14 Applications of Biosynthesized Nanoparticles -- 15 Toxicity Aspects of Biologically Synthesized Nanoparticles -- 16 Nanobiotechnology: Present Status and Future Prospects.
    Kurzfassung: This book discusses the fundamental concepts of the green synthesis of nanoparticles and presents the latest advances in this emerging field. Providing a comprehensive overview of developments related to nanoparticle synthesis using fungi, algae, bryophytes, pteridophytes, gymnosperms, monocotyledons, dicotyledonous (angiosperms) and animal systems, it also explores techniques for the characterization of these nanoparticles. Lastly, it reviews the applications and toxicity of biologically synthesized green nanoparticles. Given its scope, it is a valuable resource for students, researchers and policymakers working in the field of nanobiotechnology and nanoscience.
    Materialart: Online-Ressource
    Seiten: XIII, 352 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811671067
    URL: https://doi.org/10.1007/978-981-16-7106-7
    DOI: 10.1007/978-981-16-7106-7
    DDC: 610.72
    Sprache: Englisch
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  • 67
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    Online-Ressource
    Microscopic Techniques for the Non-Expert (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Materials Microscopy. ; Crystallography. ; Nanotechnology. ; Materials Analysis. ; Imaging systems. ; Biomedical Research. ; Microscopy. ; Crystallography and Scattering Methods. ; Nanotechnology. ; Characterization and Analytical Technique. ; Imaging Techniques.
    Beschreibung / Inhaltsverzeichnis: A Beginner’s Guide to Different Types of Microscopes -- Principles of Light and Fluorescence Microscopy -- Confocal and Multiphoton Microscopy -- Scanning Probe Microscopy: tipping the path towards atomic visions -- Atomic Force Microscopy - An Advanced Imaging Technique: From Molecules to Morphologies -- Exploring the microcosm at atomic precision using Atomic Force Microscopy -- Scanning Electron Microscopy (SEM): Learning to generate and interpret the topographical aspects of materials -- Recent updates on methods, applications, and practical uses of scanning electron microscopy in various life sciences -- Transmission electron microscopy - A powerful and novel scientific technique with nanoscale resolution for characterization of materials -- Preparation of Biological Samples for SEM: Techniques and Procedures -- Index.
    Kurzfassung: This book covers fundamental microscopic techniques for Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Atomic Force Microscopy (AFM), and other microscopic tools. It provides step-by-step instructions and explanations of the basic fundamental concepts and mechanisms and guides the reader on resolving queries related to taking and analyzing microscopy images. The latest advancements and developments in microscopic equipment are described. Theoretical background on microscopy is also provided to enhance the reader’s understanding of microscopy techniques and tools. Microscopic Techniques for the Non-Expert is an ideal book for undergraduate and postgraduate students, as well as researchers with a background in environmental science, materials science, biomedicine, engineering, or bio-nanotechnology.
    Materialart: Online-Ressource
    Seiten: XII, 247 p. 127 illus., 100 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030995423
    URL: https://doi.org/10.1007/978-3-030-99542-3
    DOI: 10.1007/978-3-030-99542-3
    DDC: 610.72
    Sprache: Englisch
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  • 68
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    Online-Ressource
    Marine Biomaterials : Therapeutic Potential (2022)
    Singapore :Springer Nature Singapore :
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    Schlagwort(e): Pharmacology. ; Medicine Research. ; Biology Research. ; Therapeutics. ; Pharmaceutical chemistry. ; Biomaterials. ; Pharmacology. ; Translational Research. ; Therapeutics. ; Pharmaceutics. ; Biomaterials.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Marine biomaterials: resources, categories and applications -- Chapter 2. Cross-linked marine biopolymers for delivery of therapeutics -- Chapter 3. Chitosan and Chitooligosaccharides: Preparation, Characteristics and their Potential Application as Therapeutic Agents -- Chapter 4. Marine collagen for delivery of therapeutics -- Chapter 5. Marine Biopolymers for delivery of Gene -- Chapter 6. Hydrogel scaffolds based on alginate, gelatin, and 2-hydroxyethyl methacrylate for tissue regeneration -- Chapter 7. Tissue Engineering application of marine based materials -- Chapter 8. Marine biopolymer for theranostic applications -- Chapter 9. Marine biomaterials as carrier of drugs/biomolecules for management of bone disorders -- Chapter 10. Expanding Role of Marine Natural Compounds in Immunomodulation: Challenges and Future Perspectives -- Chapter 11. Marine origin Bioactive Peptides: novel advances in the therapeutic potential.
    Kurzfassung: This book provides updated information on marine-based biomedical carriers and their therapeutic potential. Marine biomaterials and bio-based carriers show wide application in pharmaceutical and biomedical fields to deliver small and large molecules. Biomaterial-based composites, scaffolds, or matrix systems are sound systems for controlled and prolonged drug release in target sites and control the premature release of drugs or bioactive compounds. This book discusses essential topics such as the therapeutic potential of marine collagen, management of bone disorders, gene delivery, natural marine compounds in immunomodulation, theranostic applications, tissue engineering, and regeneration. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. Marine biomaterial-based systems are popular for tissue engineering and biomedical imaging. This book is ideal for industry experts, students, and researchers in pharmaceutical sciences and pharmacology.
    Materialart: Online-Ressource
    Seiten: X, 392 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811653742
    URL: https://doi.org/10.1007/978-981-16-5374-2
    DOI: 10.1007/978-981-16-5374-2
    DDC: 615
    Sprache: Englisch
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  • 69
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    Isotopic Tracer Techniques in Preclinical Research (2022)
    Cham :Springer International Publishing :
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    Schlagwort(e): Medicine Research. ; Biology Research. ; Radiology. ; Biotechnology. ; Medical sciences. ; Biomedical Research. ; Radiology. ; Biotechnology. ; Health Sciences.
    Beschreibung / Inhaltsverzeichnis: 1. Introduction -- 2. Tracer technique in basic research -- 3. Tracer technique in applied research -- 4. Literature cited.
    Kurzfassung: This book serves as a practical guide and a manual on the application of isotopic tracers in understanding the cellular processes (e.g. molecular interactions, protein synthesis) in growth, development, and disease conditions. The techniques described in the book have been carefully chosen to underscore the role and relevance of isotopic tracers in the identification of molecular targets and mechanisms, and preclinical validation of potential therapeutics. This book is intended to be a valuable resource to non-experts that may include students, researchers, educators/teachers, and others who have an interest to understand the application of isotopic tracers in research. Each chapter includes a background, an outline of the method and underlying principles, and a detailed step-wise protocol. To augment the clarity and intellectual grasp, the chapters also include relevant illustrations and study questions. More importantly, the book covers techniques involving radioactive as well as non-radioactive tracers to expand the scope of isotopes in preclinical research including basic and applied science.
    Materialart: Online-Ressource
    Seiten: XIII, 66 p. 19 illus., 8 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030997007
    Serie: Techniques in Life Science and Biomedicine for the Non-Expert,
    URL: https://doi.org/10.1007/978-3-030-99700-7
    DOI: 10.1007/978-3-030-99700-7
    DDC: 610.72
    Sprache: Englisch
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  • 70
    Online-Ressource
    Online-Ressource
    Sphingolipid Metabolism and Metabolic Disease (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Diseases. ; Internal medicine. ; Biomedical Research. ; Diseases. ; Internal Medicine.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Sphingolipids and Cholesterol -- Chapter 2: Sphingolipids in adipose: kin or foe? -- Chapter 3: De novo sphingolipid biosynthesis in atherosclerosis -- Chapter 4: Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases -- Chapter 5: Molecular mechanisms of sphingolipid transport on plasma lipoproteins -- Chapter 6: Sphingosine 1-phosphate metabolism and signaling -- Chapter 7: Sphingomyelin synthase family and phospholipase Cs -- Chapter 8: Sphingolipid metabolism and signaling in endothelial cell functions -- Chapter 9: Cholesterol metabolism in chronic kidney disease: physiology, pathologic mechanisms, and treatment -- Chapter 10: Sphingolipids and asthma -- Chaper 11: Manifold Roles of Ceramide Metabolism in Nonalcoholic Fatty Liver Disease and Liver Cancer -- Chapter 12: Drug development in the field of sphinogolipid metabolism -- Chapter 13: Rare diseases in glycosphingolipid metabolism.
    Kurzfassung: This book provides an up-to-date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases. Focusing on the sphingolipid de novo synthesis pathway, the effect of sphingomyelin, ceramide, and sphingosine-1-phosphate, and linkage between sphingolipids and other lipids, such as cholesterol, it covers serine palmitoyltransferase, ceramide synthases, ceramidases, sphingosine kinases, and sphingomyelin synthases, and more. While highlighting how rare diseases related to abnormal glycosphingolipid metabolism, this publication introduces sphingolipid metabolism-related diseases, such as lung diseases and cancers, as well as sphingolipid circadian regulation. The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases. It offers graduate students and researchers a coherent overview of sphingolipids, as well as the limitations of current research in the field, and promotes further studies on metabolic diseases, as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase.
    Materialart: Online-Ressource
    Seiten: VIII, 213 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811903946
    Serie: Advances in Experimental Medicine and Biology, 1372
    URL: https://doi.org/10.1007/978-981-19-0394-6
    DOI: 10.1007/978-981-19-0394-6
    DDC: 610.72
    Sprache: Englisch
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  • 71
    Online-Ressource
    Online-Ressource
    Bone Quantitative Ultrasound : New Horizons (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Human physiology. ; Biotechnology. ; Ultrasonics. ; Biomedical Research. ; Human Physiology. ; Biotechnology. ; Ultrasonics.
    Beschreibung / Inhaltsverzeichnis: Preface (Claus Glüer) -- Chapter 1. Introduction (Quentin Grimal and Pascal Laugier) -- Part I: Ultrasound Methods for Skeletal Status Clinical Assessment -- Chapter 2. Quantitative Ultrasound (QUS) in the Management of Osteoporosis and Assessment of Fracture Risk: An Update (Didier Hans, Antoine Metrailler, Elena Gonzalez Rodriguez, Olivier Lamy, Enisa Shevroja) -- Chapter 3. Clinical devices for bone assessment (Kay Raum and Pascal Laugier) -- Chapter 4. Axial transmission – Techniques, devices and clinical results (Nicolas Bochud and Pascal Laugier) -- Chapter 5. Signal processing techniques applied to axial transmission ultrasound (Tho N.H.T. Tran, Kailiang Xu, Lawrence H. Le, and Dean Ta) -- Chapter 6. Ultrasonic Assessment of Cancellous Bone Based on the Two-Wave Phenomenon (Katsunori Mizuno, Yoshiki Nagatani, Isao Mano) -- Chapter 7. Pulse-echo Measurements of Bone Tissues. Techniques and Clinical Results at the Spine and Femur (Delia Ciardo, Paola Pisani, Francesco Conversano, Sergio Casciaro) -- Chapter 8. Scattering in Cancellous Bone (Keith Wear) -- Chapter 9. Ultrasound Scattering in Cortical Bone (Yasamin Karbalaeisadegh and Marie Muller) -- Chapter 10. Single-sided ultrasound imaging of the bone cortex: anatomy, tissue characterization and blood flow (Guillaume Renaud and Sébastien Salles) -- Chapter 11. Ultrasound Computed Tomography (Philippe Lasaygues, Luis Espinosa, Simon Bernard, Philippe Petit, Régine Guillermin) -- Part II: Ex vivo Measurement of Bone Material Properties: New Methods and Data -- Chapter 12. Measurement of Cortical Bone Elasticity Tensor with Resonant Ultrasound Spectroscopy (Simon Bernard, Xiran Cai and Quentin Grimal) -- Chapter 13. Documenting the anisotropic stiffness of hard tissues with resonant ultrasound spectroscopy (Xiran Cai, Simon Bernard, Quentin Grimal) -- Chapter 14. Assessing the elasticity of child cortical bone (Cécile Baron, Hélène Follet, Martine Pihioux, Cédric Payan, and Philippe Lasaygues) -- Chapter 15. Piezoelectric and Opto-Acoustic Material Properties of Bone (Atsushi Hosokawa and Mami Matsukawa) -- Part III: Emerging applications of Bone Quantitative Ultrasound -- Chapter 16. 3D Ultrasound Imaging of the Spine (Yong Ping Zheng and Timothy Tin Yan Lee) -- Chapter 17. Ultrasonic Evaluation of the Bone-Implant Interface (Yoann Hériveaux, Vu-Hieu Nguyen, Guillaume Haïat) -- Chapter 18. Adaptive ultrasound focusing through the cranial bone for non-invasive treatment of brain disorders (Thomas Bancel, Thomas Tiennot, Jean-François Aubry) -- Chapter 19. GuidedWaves in the Skull (Héctor Estrada and Daniel Razansky) -- Index.
    Kurzfassung: Many significant achievements in new ultrasound technologies to measure bone and models to elucidate the interaction and the propagation of ultrasonic waves in complex bone structures have been reported over the past ten years. Impaired bone remodeling affects not only the trabecular compartment but also the cortical one. Despite the crucial contribution of the cortical structure to the whole bone mechanical competence, cortical bone was understudied for a long time. A paradigm shift occurred around 2010, with a special focus placed on the importance of cortical bone. This has sparkled a great deal of interest in new ultrasound techniques to assess cortical bone. While our book ‘Bone Quantitative Ultrasound’ published in 2011 emphasized techniques to measure trabecular bone, this new book is devoted for a large part to the technologies introduced recently to measure cortical bone. These include resonant ultrasound spectroscopy, guided waves, scattering, and pulse-echo and tomography imaging techniques. Instrumentation, signal processing techniques and models used are detailed. Importantly, the data accumulated in recent years such as anisotropic stiffness, elastic engineering moduli, compression and shear wave speeds of cortical bones from various skeletal sites are presented comprehensively. A few chapters deal with the recent developments achieved in quantitative ultrasound of trabecular bone. These include (i) scattering-based approaches and their application to measure skeletal sites such as the spine and proximal femur and (ii) approaches exploiting the poro-elastic nature of bone. While bone fragility and osteoporosis are still the main motivation for developing bone QUS, this Book also includes chapters reporting ultrasound techniques developed for other applications of high interest such as 3-D imaging of the spine, assessment of implant stability and transcranial brain imaging. This book, together with the book ‘Bone Quantitative Ultrasound’ published in 2011 will provide a comprehensive overview of the methods and principles used in bone quantitative ultrasound and will be a benchmark for all novice or experienced researchers in the field. The book will offer recent experimental results and theoretical concepts developed so far and would be intended for researchers, graduate or undergraduate students, engineers, and clinicians who are involved in the field. The book should be considered as a complement to the first book publisher in 2011, rather than a second edition, in the sense that basic notions already presented in the first book are not repeated.
    Materialart: Online-Ressource
    Seiten: X, 429 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030919795
    Serie: Advances in Experimental Medicine and Biology, 1364
    URL: https://doi.org/10.1007/978-3-030-91979-5
    DOI: 10.1007/978-3-030-91979-5
    DDC: 610.72
    Sprache: Englisch
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  • 72
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    Online-Ressource
    Essentials of Industrial Pharmacy (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Pharmacy. ; Pharmacology. ; Pharmaceutics. ; Pharmacy.
    Beschreibung / Inhaltsverzeichnis: Drying -- Mixing -- Comminution -- Filtration -- Pharmaceutical Packaging -- Oral Emulsion -- Oral Suspensions -- Tablets and Capsules -- Oral Inhalers -- Topically Applied Products -- Sterile Products -- Industrial Hazards -- Modified Release Drug Delivery Systems -- Novel Drug Delivery System -- Polymer for Biomedical Applications -- Biotechnology Based Drugs.
    Kurzfassung: Essentials of Industrial Pharmacy is an attempt to comprehensively present, in a single book, various pharmaceutical processes and equipment that are frequently used for production of pharmaceutical dosage forms, along with quality control tests of these dosage forms. Pictorial/graphical illustrations provide easier understanding of complex pharmaceutical concepts, manufacturing processes of pharmaceutical dosage forms. Since it is imperative for pharmacy students to have a clear understanding of the basic concepts used in development of drugs into suitable and stable dosage forms. This book offers a wealth of information regarding basic aspects of pharmaceutical processes and dosage forms, in a single book, for undergraduate pharmacy students or science students (with no pharmacy background) intended to work in the pharmaceutical Industry.
    Materialart: Online-Ressource
    Seiten: XV, 298 p. 135 illus., 86 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030849771
    Serie: AAPS Advances in the Pharmaceutical Sciences Series, 46
    URL: https://doi.org/10.1007/978-3-030-84977-1
    DOI: 10.1007/978-3-030-84977-1
    DDC: 615
    Sprache: Englisch
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  • 73
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    Online-Ressource
    Cannabis/Marijuana for Healthcare (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Pharmacology. ; Medical care. ; Therapeutics. ; Neurology . ; Medicine Research. ; Biology Research. ; Pharmacology. ; Health Care. ; Therapeutics. ; Neurology. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. A Complete Patent Analysis of Cannabis/Marijuana in Drug Delivery and Disease Conditions -- Chapter 2. Neuropharmacological Approaches to Modulate Cannabinoid Neurotransmission -- Chapter 3. Cannabinoids in Cancer: Cross-talk Between Cannabinoids and miRNAs -- Chapter 4. Cannabis As A Potent Therapeutic Agent For Pharmaceutical Drugs: Recent Advancement In Drug Discovery And Human Healthcare -- Chapter 5. Cannabinoid-Based Innovative Prophylactic and Therapeutic Interventions for Neuropathic Pain and Migraine -- Chapter 6. The Legality of Use and Consumption of Cannabis (Marijuana) in the United States of America -- Chapter 7. Cannabis in Healthcare: Ethnobotanical and Pharmaceutical Perspectives and Legal Status in Turkey and The Middle East -- Chapter 8. Understanding the Pharmacokinetics, Safety Profile, and Scope of the Concerned Issue to Evade the Consumption of Cannabis/Marijuana -- Chapter 9. Traditional Uses of Cannabis in The Middle East and The Pathway to Cannabis-Based Healthcare in Israel -- Chapter 10. Traditional and Modern Health Uses of Cannabis sativa L. in Africa and its Phytochemical and Pharmacological Profile -- Chapter 11. Traditional Claims on Cannabis: An Indian and Global Scenario -- Chapter 12. Cannabis (Bhanga) in Classical Text of Ayurveda: An Evidence-Based Rationale -- Chapter 13. Cannabis-Based Cosmetic Products and Their Uses -- Chapter 14. Cannabis as A Unique and Valuable Nutraceutical Formulation for the Current and Future Global Wellbeing -- Chapter 15. Traditional, Cultural, and Nutraceutical Aspects of Cannabis in India.
    Kurzfassung: The book contains review articles providing a comprehensive overview of cannabis/marijuana’s diverse healing aspects in human healthcare (medicinal, nutraceutical, skincare, etc.). The research articles include the role of cannabis in cancer treatment, drug discovery, cosmeceutical potential, prophylactic and therapeutic use for treating neuropathic pain and migraine, pharmacokinetics, safety profile, and issues related to the consumption of cannabis/marijuana.Another salient feature of the book is a complete mapping and region- and sector-wise critical analysis of cannabis/marijuana patents on healthcare and future directions for the benefit of researchers and businesses/entrepreneurs interested in the rapidly advancing area of cannabis. The text describes cannabis/marijuana’s detailed legal aspects, production prospects, and applications for healthcare and recreational purposes in the USA. It traces the traditional roots of cannabis use in Turkey, Israel, the Middle East, Africa, and India. This unique compendium of articles will be useful as a reference book for students, researchers, academics, business houses, and all individuals interested in medicinal, nutraceutical, cosmeceutical, traditional, legal, and commercial aspects of cannabis usage.
    Materialart: Online-Ressource
    Seiten: XIX, 319 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811688225
    URL: https://doi.org/10.1007/978-981-16-8822-5
    DOI: 10.1007/978-981-16-8822-5
    DDC: 615
    Sprache: Englisch
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  • 74
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    Online-Ressource
    Biomedical Visualisation : Volume 12 ‒ The Importance of Context in Image-Making (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Anatomy. ; Medical education. ; Medicine Research. ; Biology Research. ; Education Data processing. ; Information visualization. ; Anatomy. ; Medical Education. ; Biomedical Research. ; Computers and Education. ; Data and Information Visualization.
    Beschreibung / Inhaltsverzeichnis: Part I. Exciting Data and Representation -- Chapter 1. A Multimodal Social Semiotics Perspective on Teaching and Learning Using Biomedical Visualisations -- Chapter 2. Reasons for Knocking at an Empty House: Visualisation, Representation and Dissemination of Health-Related Public Engagement Media -- Chapter 3. The Evolution of Scientific Visualisations: A Case Study Approach to Big Data for Varied Audiences -- Part II. Biomedical Education: Theory and Practice -- Chapter 4. The Affordances of Visual Modes in Pedagogy on the Physics of Motion in Physiotherapy Education -- Part III. Making 3D -- Chapter 5. Mitochondria to Bitter Melon: Understanding the 3D Ultrastructure of the Cell via 2D Thin Section Reconstruction and the History of Mitochondrial Visualization -- Chapter 6. Using Molecular Visualisation Techniques to Explain the Molecular Biology of SARS-CoV-2 Spike Protein Mutations to a General Audience -- Chapter 7. Student-Perceived Value on the Use of Clay Modelling in Undergraduate Clinical Anatomy -- Part IV. Ethical Considerations -- Chapter 8. Advances in Digital Technology in Teaching Human Anatomy: Ethical Predicaments.
    Kurzfassung: This image-rich book explores the practice as well as the theory of visual representation and presents us with the importance of designing appropriate images for communication to specific target audiences. This includes the appropriate choice of high-tech digital or low-tech analogue technologies in image-making for communication within the medical education, biological research and community health contexts. We hear from medical students about the value of using clay modelling in their understanding of anatomy, from educators and curriculum designers about visual affordances in medical education and from a community-driven project in South Africa about their innovative use of locally designed images and culture-specific narratives for communicating important health information to marginalised communities. A chapter explores the evolution of scientific visualisation and representation of big data to a variety of audiences, and another presents the innovative 3D construction of internal cellular structures from microscopic 2D slices. As we embrace blended learning in anatomy education, a timely chapter prompts us to think further about and contribute to the ongoing discourse around important ethical considerations in the use and sharing of digital images of body donors. This book will appeal to educators, medical illustrators, curriculum designers, post-graduate students, community health practitioners and biomedical researchers.
    Materialart: Online-Ressource
    Seiten: XII, 191 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031108891
    Serie: Advances in Experimental Medicine and Biology, 1388
    URL: https://doi.org/10.1007/978-3-031-10889-1
    DOI: 10.1007/978-3-031-10889-1
    DDC: 611
    Sprache: Englisch
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  • 75
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    Online-Ressource
    Managing your Mental Health during your PhD : A Survival Guide (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Mental health. ; Vocational guidance. ; Medicine Research. ; Biology Research. ; Mental Health. ; Career Counseling. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Part I: Defining The Problem -- Chapter 1: Introduction -- Chapter 2: Challenging Perceptions - What is mental health anyway? -- Chapter 3: Setting the Scene - Understanding the PhD Mental Health Crisis -- Part II: Mindset Matters -- Chapter 4: Self-Care: Without you there is no PhD -- Chapter 5: Not another yoga session - University Wellbeing programs and why they so often miss the mark -- Chapter 6: “I’ll read it later” and other lies we tell ourselves – Managing Expectations and Guilt -- Chapter 7: Why you earned it – Fighting the Impostor -- Part III: Environmental Stressors -- Chapter 8: Dismantling the Ivory Tower – Systemic Issues that Might Impact your Mental Health -- Chapter 9: Perhaps it’s not you it’s them: PhD Student-Supervisor relationships -- Chapter 10: Publish or Perish – On the Myth of Meritocracy -- Chapter 11: The High-Walled Rose Garden: Understanding there is life outside the academy -- Part IV: Seeking Help -- Chapter 12: Thriving, not just surviving.
    Kurzfassung: This book explores the PhD experience as never before and provides a “survival guide” for current and prospective PhD students. The book investigates why mental health issues are so common among the postgraduate population, going beyond the statistics, looking at lived experience of both the author and as well as current PhD students, who have found balancing mental wellness with the PhD endeavour challenging. The author discusses tips and tricks she wished she had known at the start of her PhD process for managing mental health, such as managing imposter feelings, prioritizing workload, and self-care strategies to help others throughout their own journey. The book goes beyond typical mental health discussions (where the focus for improving mental health is placed on PhD students to become “more resilient”) and explores some of the often unspoken environmental factors that can impact mental health. These include the PhD student-supervisor relationship, the pressure to publish, and deep systemic problems in academia, such as racism, bullying and harassment. Finally, the book is a call to action, providing tangible improvements from the author’s perspective that university institutions can make to ensure that academia is a place for all to thrive.
    Materialart: Online-Ressource
    Seiten: XIX, 199 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031141942
    URL: https://doi.org/10.1007/978-3-031-14194-2
    DOI: 10.1007/978-3-031-14194-2
    DDC: 616.89
    Sprache: Englisch
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  • 76
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    Online-Ressource
    Peptide Therapeutics : Fundamentals of Design, Development, and Delivery (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Pharmaceutical chemistry. ; Drug delivery systems. ; Drugs Design. ; Pharmacology. ; Pharmacy. ; Proteins Synthesis. ; Pharmaceutics. ; Drug Delivery. ; Structure-Based Drug Design. ; Pharmacology. ; Pharmacy. ; Protein Synthesis and Translation.
    Beschreibung / Inhaltsverzeichnis: Basic Concepts of Design of Peptide based Therapeutics -- Computational Methods in Peptide Based Drug Design -- Synthesis, Purification, and Characterization of Linear and Cyclic Peptides -- Large Scale Synthesis of Peptides, Manufacturing Peptide Therapeutics -- Stability of Peptides -- Peptide Delivery Systems -- Liposomes and Nanoparticle Formulations for Peptide Delivery -- Delivery of Peptides Across the Blood-brain Barrier (BBB) -- Peptide Therapeutics Regulatory Considerations.
    Kurzfassung: This book explains how peptide-based drug design works, what steps are needed to develop a peptide-based therapeutic, and challenges in synthesis as well as regulatory issues. It covers the design concept of peptide therapeutics from fundamental principles using structural biology and computational approaches. The chapters are arranged in a linear fashion. A fresh graduate or a scientist who works on small molecules can use this to follow the design and development of peptide therapeutics to use as understanding the basic concepts. Each chapter is written by experts from academia as well as industry. Rather than covering extensive literature, the book provides concepts of design, synthesis, delivery, as well as regulatory affairs and manufacturing of peptides in a systematic way with examples in each case. The book can be used as a reference for a pharmaceutical or biomedical scientist or graduate student who wants to pursue their career in peptide therapeutics. Some chapters will be written as a combination of basic principles and protocol so that scientists can adopt these methods to their research work. The examples provided can be used to perform peptide formulation considerations for the designed peptides. The book has nine chapters, and each chapter can be read as an independent unit on a particular concept.
    Materialart: Online-Ressource
    Seiten: IX, 317 p. 52 illus., 42 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031045448
    Serie: AAPS Advances in the Pharmaceutical Sciences Series, 47
    URL: https://doi.org/10.1007/978-3-031-04544-8
    DOI: 10.1007/978-3-031-04544-8
    DDC: 615.19
    Sprache: Englisch
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  • 77
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    Online-Ressource
    Transdisciplinarity (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Art Study and teaching. ; Biomedical engineering. ; Philosophy. ; Economic sociology. ; Biomedical Research. ; Creativity and Arts Education. ; Biomedical Engineering and Bioengineering. ; Philosophy. ; Economic Sociology.
    Beschreibung / Inhaltsverzeichnis: 1 Introduction on Integrated Science: Transdisciplinary across the Different Disciplines -- 2 Chaos Theoretical Explanation to Each Development of Evolution Theory, Psychology, Physics, and Philosophy -- 3 Managerial Problems and Cultural Heritage in Information Technology -- 4 On the Essential Unity of Mathematics, Science, and Art: The Justice Evaluation Function and the Golden Number -- 5 Integration of Film Theory and Studies with Neuroscience -- 6 Systems View in Engineering Research -- 7 Molecular Dynamics Simulations: Concept, Methods, and Applications -- 8 The World Big Challenges Faced by Nanoscience: Examples of How Integrated Science Can Save the World -- 9 The Kaleidoscopic Image as an Intersection between Art and Science: From Microscopic Forms to Cosmological Models -- 10 Disruptions and Competitive Strategies in the Automotive Industry -- 11 Macroeconomics: From Equilibrium Settings to Multi-Agent Worlds -- 12 A Multi-level Perspective to Biosimilars Development: Pathways Towards Incremental Innovation in the Health Bioeconomy -- 13 A 2020s Marketing Taxonomy for Augmented Reality Customer Experience -- 14 Can Viral Marketing Content Spread according to the Rumour Formula? -- 15 Exaptation as a Design Strategy for Resilient Communities -- 16 Ecosystem management and climate-smart agriculture -- 17 A new generation of shrimp aquaculture for sustainability and resilience of future green cities -- 18 Public Understanding of Geoethics Dilemmas: A Case Study on Lithium Exploitation -- 19 Creative Approaches for Mitigating Environmental Challenges: A Cosmopolitan Localism Perspective -- 20 Landscape: A Holistic Approach to Space -- 21 Integrated Approaches to Land Management -- 22 Archaeology as an Interdisciplinary Science at the Cross-Roads of Physical, Chemical, Biological, and Social Sciences: New Perspectives and Research -- 23 Biomimicry in Architecture: From Theory to Practice -- 24 Ecodemocracy in Practice: Examples of Forestry and Food Production -- 25 Semantic Analyses of Hilary Putnam’s Twin Earth (ft. TE Diagram) -- 26 Sport Sciences: An Ideal Field of Play for Integrated Knowledges -- 27 Single Valued Neutrosophic Set: An Overview -- 28 Technology Assessment Integrated research for scientific policy advice -- 29 The Artistic and Scientific Nature of Protein Structure: A Historical Overview -- 30 The Art and Science of Biomimicry – Abstracting Design Principles from Nature -- 31 The Phenomenon of Meeting in Art: A Transdisciplinary Approach -- 32 The Phenomenon of Meeting in Art: A Transdisciplinary Approach.
    Kurzfassung: This contributed volume book aims at discussing transdisciplinary approaches to address common problems. By working transdisciplinarily, researchers coming from different disciplines can work jointly using a shared conceptual framework bringing together disciplinary-specific theories and concepts. There are numerous barriers that can obstruct effective communication between different cultures, communities, religions and geographies. This book shows that through bringing together different disciplines, researchers not only can surpass these barriers but can effectively produce new venues of thought that can positively affect the development and evolution of research and education. The book discusses new and emerging applications of knowledge produced by transdisciplinary efforts and covers the interplay of many disciplines, including agriculture, economics, mathematics, engineering, industry, information technology, marketing, nanoscience, neuroscience, space exploration, human-animal relationships, among others. Consequently, it also covers the relationship between art and science, as one of the most remarkable transdisciplinary approaches that paves the way for new methods in engineering, design, architecture and many other fields. .
    Materialart: Online-Ressource
    Seiten: XIII, 741 p. 239 illus., 193 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030946517
    Serie: Integrated Science, 5
    URL: https://doi.org/10.1007/978-3-030-94651-7
    DOI: 10.1007/978-3-030-94651-7
    DDC: 610.72
    Sprache: Englisch
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    The Centrosome and its Functions and Dysfunctions (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Cytology. ; Reproduction. ; Physiology. ; Medicine Research. ; Biology Research. ; Cancer. ; Developmental biology. ; Cell Biology. ; Reproductive Physiology. ; Biomedical Research. ; Cancer Biology. ; Developmental Biology and Stem Cells.
    Beschreibung / Inhaltsverzeichnis: Cell and Molecular Biology of Centrosome Structure and Function -- The centrosome Cycle within the cell cycle -- Centrosome as center for proteolytic activity and dysfunctions associated with pathogenesis of human disease -- Centrosome dysfunctions in cancer -- Virus exploitation of centrosomes -- Centrosomes in reproduction -- Transition from centrosomal to non-centrosomal microtubule organization during cellular polarization -- External and environmental effects on Centrosomes -- Centrosomes and centrosome equivalents in other systems -- Non-centrosomal microtubule organization in plant cells.
    Kurzfassung: The book provides a comprehensive overview of classic and modern approaches of centrosome research, including new aspects of centrosome functions focusing on primary cilia and their implications in numerous diseases. In addition, several chapters raise awareness of centrosomes in areas that have not yet fully considered the centrosome as an organelle that impacts other organelle functions directly or indirectly. It further relates centrosome functions to other research areas such as aging and stem cell research. Since its discovery almost 150 years ago the centrosome is increasingly being recognized as a most impactful organelle for its role, not only as primary microtubule organizing center (MTOC) but also as a major communication center for signal transduction pathways and as a center for proteolytic activities. Its significance for cell cycle regulation has been well studied and we now also know that centrosome dysfunctions are implicated in numerous diseases and disorders including cancer, cystic diseases of the kidney, liver fibrosis, cardiac defects, obesity and several other diseases and disorders. This new volume reviews the latest advances in the field and provides valuable background information that is readily understandable for the newcomer and the experienced centrosome researcher alike. Due to the interdisciplinary of the subject, it is a valuable resource for researchers and clinicians working in biomedical research, cell biology, cancer biology, reproduction and developmental biology, neuroscience and stem cell research. .
    Materialart: Online-Ressource
    Seiten: VII, 111 p. 18 illus., 17 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031208485
    Serie: Advances in Anatomy, Embryology and Cell Biology, 235
    URL: https://doi.org/10.1007/978-3-031-20848-5
    DOI: 10.1007/978-3-031-20848-5
    DDC: 571.6
    Sprache: Englisch
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  • 79
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    Broadly Engaged Team Science in Clinical and Translational Research (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Clinical medicine Research. ; Public health. ; Political planning. ; Social medicine. ; Biomedical Research. ; Translational Research. ; Clinical Research. ; Public Health. ; Policy Formulation. ; Health, Medicine and Society.
    Beschreibung / Inhaltsverzeichnis: 1. Introduction -- Part I Transforming Research with Broad Engagement -- 2. The Transformative Power of Broadly Engaged Team Science: A Moth-er’s Quest to Understand PXE -- 3. Broadly Engaged Team Science in Neonatal Research -- 4. Patient Advocates in Cancer Care: A Rich Tradition and Evolving Role -- 5. National Kidney Foundation Patient Network -- 6. Broadly Engaged Team Science Comes to Life in a Design Lab -- 7. Tufts Center for the Study of Drug Development Employs Broadly Engaged Team Science to Explore the Challenges of Pharmaceutical Research and Development -- Part II. Integrating Communities and Stakeholders into Broadly Engaged Team Science -- 8. Social Movements and Stakeholder Engagement -- 9. A Basic Scientist’s Journey: Engaging Public Stakeholders Through Civic Science -- 10. Lessons in Public Involvement from Across the Pond -- 11. Leveling the Playing Field for Community Stakeholders: Examining Practices to Improve Engagement and Address Power Dynamics -- 12. A Theory of Stakeholder-driven Community Diffusion -- 13. Monitoring and Evaluation of Stakeholder Engagement in Health Research -- Part III. Applying Broadly Engaged Team Science: Case Studies -- 14. Insiders and Outsiders: A Case Study of Fostering Research Partnerships between Academic Health Centers and Corrections Institutions -- 15. Responding to the Community: HOPE (Healthy Outcomes from Positive Experiences) -- 16. Students as Key Collaborators in Tackling Early Stage Research Ideas -- 17. Engaging Stakeholders to Decrease Study Start-up Delays -- 18. Health Literacy and Broadly Engaged Team Science: How One Study Team Used Plain Language Principles to Share Findings with Affected Communities -- 19. Utilizing Patient Navigators to Promote Equitable and Accountable Research -- 20. Asian American Research in the Post-Atlanta Era: Driving Community-engaged Research That Is More Meaningful, Responsive, and Actionable for Local Communities -- 21. Stakeholder Engagement in Predictive Model Development for Clinical Decision Support -- Part IV. Creating an Institutional Environment of Support for Broadly Engaged Team Science -- 22. Research Administration Practices for Proposal Development and Post-Award Management of Stakeholders and Community Participants -- 23. Starting Off Right: Supporting Community Involvement in the Evaluation of Research Proposals -- 24. Role of Broadly Engaged Team Science in the Inclusion of Minority Populations as Research Participants and in All Roles on Research Teams -- 25. Rewarding Team Science in Tenure and Promotion Practices: An Operational Imperative for the Academic Research Enterprise of the 21st Century -- Epilogue.
    Kurzfassung: Despite the large U.S. investment in health science, and the vast and growing body of peer-reviewed research findings it has produced, a compelling body of evidence suggests that research too often has been slow, inefficient, and fallen short of desired impacts on health. A key question is how research might be changed to be more innovative, less wasteful, and more responsive to unmet health needs. One emerging response within clinical and translational science is to advance an approach that attempts to close the gap between research scientists and key stakeholders; the individuals and groups responsible for or affected by health-related decisions. Broadly engaged team science promises to support this aim by transforming the gold standard, multi-disciplinary team science, to include key stakeholders in activities across the research spectrum. These new roles and responsibilities range from generating research questions to implementing research projects, to aiding in the translation of discoveries from the laboratory to the community. A transition to broadly engaged team science reflects the idea that inclusivity and a diversity of perspectives are necessary to achieving progress in addressing complex health issues while representing a new benchmark for ethical research practice. This is one of the first collections of papers describing how clinical and translational science researchers are defining and implementing new research practices, and the successes and challenges involved. This book represents a first and critical step towards organizing knowledge of broadly engaged team science and advancing the development of evidence-based practices. Written in an accessible style, this book is intended to highlight the breadth of broadly engaged team science within one community, motivate researchers and stakeholders to build inclusive teams, bring rigor to often informal stakeholder engagement research practices and encourage people to think more broadly about the development of scientific knowledge. It includes examples of multi-disciplinary, broadly engaged team science projects, the perspectives of academic leaders about the changes needed to encourage scientists to conduct broadly engaged team science, and a resource directory.
    Materialart: Online-Ressource
    Seiten: XV, 260 p. 25 illus., 23 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030830281
    URL: https://doi.org/10.1007/978-3-030-83028-1
    DOI: 10.1007/978-3-030-83028-1
    DDC: 610.72
    Sprache: Englisch
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  • 80
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    Online-Ressource
    Drug Delivery to the Brain : Physiological Concepts, Methodologies and Approaches (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Drug delivery systems. ; Neuropharmacology. ; Medicine Research. ; Biology Research. ; Pharmaceutical chemistry. ; Drug Delivery. ; Neuropharmacology. ; Biomedical Research. ; Pharmaceutics.
    Beschreibung / Inhaltsverzeichnis: Part I-Physiology and Basic Principles of Drug Handling for the CNS -- Anatomy and Physiology of the Blood Brain Barriers -- Drug Delivery to the Brain: Integrating Neuroscience, Physiology, and Brain Barriers Science -- Brain Delivery of Therapeutics via Transcytosis: Types and Mechanisms of Vesicle-Mediated Transport Across the BBB -- Brain- Arachnoid Barrier as an Important Clearance Pathway from CSF -- BBB Pharmacoproteomics: Quantitative Targeted Absolute Proteomics (QTAP): Species Differences -- Drug Metabolism at the BBB and the BCFSB -- PART II-PK Concepts and Methods for Studying CNS Drug Delivery -- Pharmacokinetics Concepts in Brain Drug Delivery -- In Vitro Models of CNS Barriers -- Human In Vitro BBB Models Derived from Pluripotent Stem Cells -- In situ and In vivo Animal Models -- Principles of PET and Its Role in Understanding Drug Delivery to the Brain -- Prediction of CNS PK and PD Using Translational Research Approaches -- Part III-Industrial Approaches for Investigation of Potential CNS Drugs -- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution -- Prediction of Drug Exposure in the Brain From the Chemical Structure -- Integrated Approach to Optimizing CNS Penetration in Drug Discovery -- Part IV: Strategies for Improved CNS Drug Delivery -- Intranasal Drug Delivery to the Brain -- Blood to Brain Drug Delivery Using Nanocarriers -- Enhancing CNS Exposure Through Brain Endothelial Cell RMT-Exploiting the Transferrin Receptor at the BBB -- Therapeutic Osmotic Modification of the BBB in the Treatment of CNS Pathologies -- Biophysical Perspectives on BBB Permeability Enhancement by Ultrasound and Microbubbles for Targeted Drug Delivery in the Clinical Setting -- Optimization of Blood Brain Barrier Opening With Focused Ultrasound-The Animal Perspective -- CNS Gene Therapy Using Adeno-Associated Virus (AAV) Vectors -- Part V-CNS Drug Delivery in Disease Conditions -- Disease Influence on BBB Transport in Neurodegeneration and Neuroinflammation -- Enhancing Drug Delivery in the Setting of Stroke and Brain Injury -- Drug Delivery to tumor Metastases in the Brain-(Including PK PD Free Fraction Active Conc.) -- Drug Delivery to Primary Tumors in the Brain-(Including PK PD Free Fraction Active Conc.) -- Appendix:CNS Anatomy, Function, Vasculature and Fluid Exchange: Primer for Drug Delivery Scientists.
    Kurzfassung: The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. .
    Materialart: Online-Ressource
    Seiten: XXI, 806 p. 199 illus., 179 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2022.
    ISBN: 9783030887735
    Serie: AAPS Advances in the Pharmaceutical Sciences Series, 33
    URL: https://doi.org/10.1007/978-3-030-88773-5
    DOI: 10.1007/978-3-030-88773-5
    DDC: 615.6
    Sprache: Englisch
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  • 81
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    Online-Ressource
    Biotechnologies for Gene Therapy : RNA, CRISPR, Nanobots, and Preclinical Applications (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medical genetics. ; Biomedical engineering. ; Biotechnology. ; Pharmaceutical chemistry. ; Medical Genetics. ; Biomedical Engineering and Bioengineering. ; Biotechnology. ; Pharmaceutics.
    Beschreibung / Inhaltsverzeichnis: 1. Therapeutic potential of microRNAs and their nanoparticle-based delivery in the treatment of liver fibrosis -- 2. MicroRNA as a versatile regulator of Wnt signaling pathway in colorectal cancer -- 3. Small Activating RNA Therapy for Angiogenesis -- 4. Muscular dystrophy therapy using viral vector-based CRISPR/Cas -- 5. CRISPR-Cas based gene therapy to target viral infections -- 6. CRISPR targeting the integrated HTLV-1 virus -- 7. Retroviral vectors for gene therapy of monogenic diseases -- 8. DNA Origami Nanodevices for Therapeutic Delivery Applications.
    Kurzfassung: The purpose of this book is to highlight some of latest developments and applications of CRISPR, RNA, and DNA to treat diseases ranging from cancers to cardiovascular and degenerative disorders. It also features innovations of the delivery methods for nucleic acids ranging from nanodevices made from DNA and pseudo amino acids to viral vectors. This is an ideal book for academics, clinicians, and students interested in gene therapy.
    Materialart: Online-Ressource
    Seiten: IX, 203 p. 26 illus., 23 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030933333
    URL: https://doi.org/10.1007/978-3-030-93333-3
    DOI: 10.1007/978-3-030-93333-3
    DDC: 616.042
    Sprache: Englisch
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  • 82
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    Online-Ressource
    Translational Informatics : Prevention and Treatment of Viral Infections (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Bioinformatics. ; Virology. ; Medical informatics. ; Biomedical Research. ; Bioinformatics. ; Virology. ; Health Informatics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Databases, Knowledgebases and Software Tools for Virus Informatics -- Chapter 2. Detection and Prevention of Virus Infection -- Chapter 3. Bioinformatics for the Origin and Evolution of Viruses -- Chapter 4. In silico Drug Discovery for Treatment of Virus Diseases -- Chapter 5. Vaccines and Immunoinformatics for Vaccine Design -- Chapter 6. Predicting the Disease Severity of Virus Infection -- Chapter 7. Modeling the Virus Infection at the Population Level -- Chapter 8. Health-Based Geographic Information Systems for Mapping and Risk Modeling of Infectious Diseases and COVID-19 to Support Spatial Decision-Making -- Chapter 9. 5G, Big data and AI for Smart City and Prevention of Virus Infection.-.
    Kurzfassung: This book introduces the translational informatics applied to most aspects of virus infection, including tracking of virus origin, detection and prevention of infection, drug discovery, and vaccine design as well as smart city-level monitoring and controlling of the virus epidemic by government. It covers the informatics for data mining and modelling at molecular, tissue/organ, individual, and population levels. The informatics for immunological mechanisms and the personalized prediction and treatment of infected patients are also summarized. The perspectives on the application of artificial intelligence to the prevention of virus outbreaks are also given. This book will be helpful to readers who are interested in prevention of virus infection, biomedical informatics, and artificial intelligence in medicine and healthcare.
    Materialart: Online-Ressource
    Seiten: VII, 218 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811689697
    Serie: Advances in Experimental Medicine and Biology, 1368
    URL: https://doi.org/10.1007/978-981-16-8969-7
    DOI: 10.1007/978-981-16-8969-7
    DDC: 610.72
    Sprache: Englisch
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  • 83
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    Online-Ressource
    HDL Metabolism and Diseases (2022)
    Singapore :Springer Nature Singapore :
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    Schlagwort(e): Medicine Research. ; Biology Research. ; Human physiology. ; Life sciences. ; Pharmacology. ; Biomedical Research. ; Human Physiology. ; Life Sciences. ; Pharmacology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: HDL Structure -- Chapter 2: HDL and Cholesterol ester transfer protein (CETP) -- Chapter 3: HDL and Endothelial Function -- Chapter 4: HDL and lipid metabolism -- Chapter 5: HDL and oxidation -- Chapter 6: Scavenger Receptor Class B Type I and HDL -- Chapter 7: ABCA1, ABCG1 and cholesterol homeostasis -- Chapter 8: HDL and ASCVD -- Chapter 9: HDL and Diabetes -- Chapter 10: HDL and sepsis -- Chapter 11: HDL mimetic peptides -- Chapter 12: HDL and microRNAs -- Chapter 13: HDL-kidney diseases -- Chapter 14: HDL and therapy -- Chapter 15: High-density lipoprotein and Surgery.
    Kurzfassung: This book focuses on both high-density lipoproteins (HDL) metabolism and related diseases from the perspectives of the world-class experts in HDL. Several chapters in this book provide the overall information about HDL metabolism via detailed discussion of HDL structures as well as several key molecules involved in its functions, such as SR-B1 and Cholesteryl Ester Transfer Protein Inhibitors and so on. The rest of this book illustrates the connection between HDL and several diseases that are the major concerns of people’s health in many countries, and devotes to exploring the therapies of HDL related diseases. With a better understanding of the HDL metabolism and diseases, this book will benefit the audiences with interest in HDL from biomedicine to clinical practice.
    Materialart: Online-Ressource
    Seiten: X, 195 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811915925
    Serie: Advances in Experimental Medicine and Biology, 1377
    URL: https://doi.org/10.1007/978-981-19-1592-5
    DOI: 10.1007/978-981-19-1592-5
    DDC: 610.72
    Sprache: Englisch
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  • 84
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    Online-Ressource
    Drug Target Selection and Validation (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Drugs Design. ; Medicinal chemistry. ; Molecular biology. ; Pharmacology. ; Pharmaceutics. ; Structure-Based Drug Design. ; Medicinal Chemistry. ; Molecular Biology.
    Beschreibung / Inhaltsverzeichnis: Drug discovery paradigms: target-based drug discovery -- Drug discovery paradigms: phenotypic-based drug discovery -- Target Identification Approaches in Drug Discovery -- Introduction to target validation -- Structure-based binding pocket detection and druggability assessment -- Network-Based Target Identification -- The Current State of Precision Medicine and Targeted-Cancer Therapies – Where are We? -- Metabolic Control Analysis for drug target selection against human diseases -- Progress on open chemoinformatic tools for drug discovery.
    Kurzfassung: The first book in the newly created book series, Computer-Aided Drug Discovery and Design, focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.
    Materialart: Online-Ressource
    Seiten: XV, 257 p. 37 illus., 33 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030958954
    Serie: Computer-Aided Drug Discovery and Design, 1
    URL: https://doi.org/10.1007/978-3-030-95895-4
    DOI: 10.1007/978-3-030-95895-4
    DDC: 615
    Sprache: Englisch
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  • 85
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    Online-Ressource
    Tumor Suppressor Par-4 : Structural Features, Molecular Mechanisms and Function (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Internal medicine. ; Biomedical Research. ; Internal Medicine.
    Beschreibung / Inhaltsverzeichnis: Discovery and Overview of Par-4 -- Par-4 in cell cycle regulation -- Conformational studies of the Par-4 C-terminal Domain -- Structural analysis of Par-4 and crystallographic analysis of the regulatory domain -- Regulation of Par-4 by Ubiquitinases -- REGULATION OF PAR-4 FUNCTION BY PHOSPHORYLATION -- Role of Par-4 in GRP78 translocation -- PAR-4 in the regulation of stem cell death and embryo development -- RASSF2 and the PAR-4 connection -- Regulation of tumor suppressor Par-4 by ceramide -- PAWR as a direct SRC-1/HOXC11 suppression target -- Index.
    Kurzfassung: Par-4 is a tumor suppressor protein first discovered and identified in 1993 by Dr. Vivek Rangnekar’s laboratory in prostate cancer cells undergoing apoptosis. Par-4 (later also known as PAWR) is a naturally occurring tumor suppressor. Studies have indicated that Par-4 selectively induces apoptosis in cancer cells while leaving normal, healthy, cells unaffected. Mechanisms contributing to the cancer-selective action of Par-4 have been associated with protein kinase A activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. Par-4 is downregulated, inactivated or mutated in diverse cancers. This first of two volumes will be the first on the market on the topic of Par-4, and will provide the opportunity for researchers to discuss the future direction of studies, broaden the scope of research, and contribute a more complete understanding of the molecule’s structural features, key functional domains, regulation and relevant basic and clinical/translational facets.
    Materialart: Online-Ressource
    Seiten: X, 323 p. 84 illus., 81 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030735722
    URL: https://doi.org/10.1007/978-3-030-73572-2
    DOI: 10.1007/978-3-030-73572-2
    DDC: 610.72
    Sprache: Englisch
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  • 86
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    Online-Ressource
    Promising Antimicrobials from Natural Products (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Pharmacology. ; Pharmaceutical chemistry. ; Medicinal chemistry. ; Toxicology. ; Natural products. ; Pharmacology. ; Pharmaceutics. ; Medicinal Chemistry. ; Toxicology. ; Natural Products.
    Beschreibung / Inhaltsverzeichnis: Section I: General, Identity and Taxonomy -- The genus Phoma: What we know and what we need to know? -- Taxonomical evaluation of Phoma- history of classification, current status and future directions -- Section II: Diversity, Diseases and Host Range -- Phoma on medicinal and aromatic plants -- Diseases of fruits, tubers, and seeds caused by Phoma sensu lato species complex -- Overview of Phoma-like fungi on important legumes (Papilionaceous plants) -- Diseases of vegetables caused by Phoma spp -- Phoma diseases: identification, epidemiology and strategies for management -- Major plant diseases caused by Phoma sensu lato species and their integrated management strategies -- Phoma as an infectious pathogen in medical practice -- Section III: Secondary metabolites and Bioactivities -- Fruitful decade of Phoma secondary metabolites from 2011 to 2020: Chemistry, chemical diversity and biological activities -- Bioactive secondary metabolites from endophytic Phoma spp -- The genus Phoma: a review of its potential bioactivities, implications and prospects -- Bioherbicidal activity of Phoma macrostoma -- New technologies for the formulation of secondary metabolites produced by Phoma sp. for biological control of weeds -- Biological management of plant diseases by non-pathogenic Phoma spp -- Plant growth promoting Phoma spp -- Section IV:Nanotechnology and Fossil records of Phoma -- Potential role of Phoma spp. for mycogenic synthesis of Silver nanoparticles -- In situ occurrence of Phomites Fritel in the phyllosphere of ancient Siwalik forests of eastern Himalaya during the Mio-Pleistocene.
    Kurzfassung: Given novel infectious diseases such as COVID-19 and antibiotic resistance new antimicrobial discovery is an important research area. Considering that nature is a vast source of bioactive molecules with antimicrobial activity, the main aim of this book is to present a comprehensive outlook of current research in the field of natural antimicrobials. It discusses the antimicrobial activity of medicinal plants, beehives, and mushrooms with a global coverage of antimicrobial agents from rich forests of Brazil (Amazon), North-Eastern forests of Peru, Argentina, Colombia, India, Bangladesh, Nepal, Middle East, Turkey, Croatia, Greece, Germany and Russia. The book covers the results of the in vitro screening of antimicrobial activities of extracts and isolated compounds from natural origins. It is divided into three sections: i) Section I, includes natural antimicrobials from plants; ii) Section II incorporates antimicrobial agents/secondary metabolites from plants, and (iii) Section III focuses on antimicrobials from mushrooms, beehive and delivery systems for different types of antimicrobials. Promising Antimicrobials From Natural Products is immensely useful for post graduate students, researchers in plant science, microbiology, biotechnology, pharmacology, pharma companies and those who are interested in herbal, eco-friendly, cost-effective and sustainable antimicrobials. Contains results of in vitro screening of extracts and isolated compounds Focuses on delivery systems Covers antimicrobial medicinal plants of Brazil (Amazon), North-Eastern forests of Peru, Argentina, Colombia, India, Bangladesh, Nepal, Middle East, Turkey, Croatia, Greece, Germany and Russia.
    Materialart: Online-Ressource
    Seiten: XIII, 451 p. 94 illus., 28 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030835040
    URL: https://doi.org/10.1007/978-3-030-83504-0
    DOI: 10.1007/978-3-030-83504-0
    DDC: 615
    Sprache: Englisch
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    Virus Entry Inhibitors : Stopping the Enemy at the Gate (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Virology. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Virology. ; Medical Microbiology. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Peptide virus entry inhibitors: past, present and future -- Small-molecule virus entry inhibitors -- Human endogenous virus entry inhibitors -- Lipopeptide HIV entry inhibitors -- Peptide HIV entry inhibitors targeting gp41 NHR -- Small-molecule HIV entry inhibitors targeting gp41 MPER -- Small-molecule HIV entry inhibitors targeting CD4-binding site in gp120 -- Small-molecule HIV entry inhibitors targeting gp120 -- SARS-CoV, MERS-CoV, and pan-coronavirus entry inhibitors -- Hendra virus (HeV) and Nipah virus (NiV) entry inhibitors -- Ebola virus entry inhibitors -- Cyclo-peptide-based Ebola virus entry inhibitors -- Influenza virus entry inhibitors -- Parainfluenza virus entry inhibitors -- Zika virus entry inhibitors -- HBV entry inhibitors -- HBV and HDV entry inhibitors -- HCV entry inhibitors -- Protein-based HPV entry inhibitors.
    Kurzfassung: This book focuses on the important discoveries of the small molecule-, peptide-, and protein-based virus entry inhibitors and discusses advance of the development of different type of virus entry inhibitors as a novel class of antiviral drugs for treatment and prevention of viral infection. It includes entry inhibitors of HIV,HeV, NiV, RSV, EBOV, HCoV, HBV, HCV, HDV, HPV, flavivirus and influenza virus, so on. This book aims at providing an updated knowledge on virus entry inhibitors.
    Materialart: Online-Ressource
    Seiten: X, 239 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811687020
    Serie: Advances in Experimental Medicine and Biology, 1366
    URL: https://doi.org/10.1007/978-981-16-8702-0
    DOI: 10.1007/978-981-16-8702-0
    DDC: 579.2
    Sprache: Englisch
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  • 88
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    Online-Ressource
    Integrative Bioinformatics : History and Future (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Bioinformatics. ; Data mining. ; Application software. ; Biomedical Research. ; Bioinformatics. ; Data Mining and Knowledge Discovery. ; Computer and Information Systems Applications.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Integrative Bioinformatics: History and Perspective -- Chapter 2. From Genotypes to Phenotypes - A Plant Perspective on Current Developments in Data Management and Data Publication -- Chapter 3. Research data resources for epidemiology -- Chapter 4. Data Warehousing of Life Science Data -- Chapter 5. Automation in Graph-Based Data Integration and Mapping -- Chapter 6. DaTo: an Integrative Web Portal for Biological Databases and Tools -- Chapter 7. The Use of Data Integration and Knowledge Graphs in Modern Molecular Plant Breeding -- Chapter 8. Integrative data analysis and exploratory data mining in biological knowledge graphs -- Chapter 9. Exploring plant transcription factor regulatory networks -- Chapter 10. Microbiome and big-data mining -- Chapter 11. Data Integration Applications in Medical Information Systems -- Chapter 12. Visualising Metabolic Pathways and Networks: Past,Present,Future -- Chapter 13. Comprehensive open-source Petri net toolchain for modeling and simulation in systems biology -- Chapter 14. Immersive Exploration of Cell Localization Scenarios using VR, Spatialized Video Communication and Integrative Bioinformatics -- Chapter 15. IoS: a Needed Platform for Scientific Workflow Management -- Chapter 16. Revealing genotype-phenotype interactions: The AgroLD experience and challenges -- Chapter 17. Interactive Data Analyses Using Tbtools -- Chapter 18. Analyzing multi-omic data with integrative platforms.
    Kurzfassung: This book provides an overview of the history of integrative bioinformatics and the actual situation and the relevant tools. Subjects cover the essential topics, basic introductions, and latest developments; biological data integration and manipulation; modeling and simulation of networks; as well as a number of applications of integrative bioinformatics. It aims to provide basic introduction of biological information systems and guidance for the computational analysis of systems biology. This book covers a range of issues and methods that unveil a multitude of omics data integration and relevance that integrative bioinformatics has today. It contains a unique compilation of invited and selected articles from the Journal of Integrative Bioinformatics (JIB) and annual meetings of the International Symposium on Integrative Bioinformatics.
    Materialart: Online-Ressource
    Seiten: XI, 386 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811667954
    URL: https://doi.org/10.1007/978-981-16-6795-4
    DOI: 10.1007/978-981-16-6795-4
    DDC: 610.72
    Sprache: Englisch
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  • 89
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    New and Future Development in Biopesticide Research: Biotechnological Exploration (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Microbiology. ; Pharmacology. ; Biotechnology. ; Medicine Research. ; Biology Research. ; Microbiology. ; Pharmacology. ; Biotechnology. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Biopesticides in sustainable agriculture: current status and future prospects -- Chapter 2. Entomopathogenic Fungi: Current Status and Prospects -- Chapter 3. Utilization of Entomopathogenic Bacteria for modern insect pest management -- Chapter 4. Entomopathogenic Nematodes (EPNs): A Green Strategy for Management of Insect-Pests of Crops -- Chapter 5. Trends in neem (Azadirachta indica)-based botanical pesticides -- Chapter 6. Role of Plant Essential Oils in Pest Management -- Chapter 7. Plant Secondary Metabolites: Emerging Trends in Agricultural Pests Control -- Chapter 8. Transgenic plants and its role in insect control -- Chapter 9. Improving Insect Control Using Genetically Modified Entomopathogens -- Chapter 10. Importance of metabolic enzymes and their role in insecticide resistance -- Chapter 11. Insect microbiota and host immunity: An emerging target for pest control.-Chapter 12. Eco-smart Biorational Approaches in Housefly Musca domestica L. 1758 Management.
    Kurzfassung: This book discusses different approaches for successful pest-management through biotechnological interventions. Pest management is directly associated with the agricultural productivity. The book introduces the reader to various kinds of biopesticides that have been developed and are being developed for field application. Chemical pesticides have been widely used to control pests, and these induce pesticide resistance as well as other environmental problems. This book discusses the necessity to develop alternate pest control strategies, especially environment-friendly and target-specific biopesticides against destructive pests. The book describes important aspects such as microbial biopesticides, plant-based biopesticides, natural products that act against pests and the various other biotechnological advances and limitations of these biopesticides. It provides an in-depth knowledge of the latest research and development in the area of biopesticides. This informative book is meant for students and researchers in the fields of biotechnology, agriculture and applied microbiology.
    Materialart: Online-Ressource
    Seiten: VIII, 303 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811639890
    URL: https://doi.org/10.1007/978-981-16-3989-0
    DOI: 10.1007/978-981-16-3989-0
    DDC: 579
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 90
    Online-Ressource
    Online-Ressource
    Natural Products as Enzyme Inhibitors : An Industrial Perspective (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Natural products. ; Food science. ; Agriculture. ; Pharmaceutical chemistry. ; Biomedical Research. ; Natural Products. ; Food Science. ; Agriculture. ; Pharmaceutics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Plant peptides as protease inhibitors for therapeutic and agricultural applications -- Chapter 2.Plant peptides as protease inhibitors for therapeutic and agricultural applications -- Chapter 3.Bioactive α- Amylase Inhibitors: Sources, Mechanism of Action, Biochemical Characterization and Applications -- Chapter 4.Recent Updates on In silico Screening of Natural Products as Potential Inhibitors of Enzymes of Biomedical and Pharmaceutical Importance -- Chapter 5.H+/K+-ATPase inhibitors from plants: A potential source for drug discovery -- Chapter 6.Use of protease inhibitors as a promising alternative for pest control -- Chapter 7. Pancreatic lipase (PL) inhibitors from medicinal plants and their potential applications in the management of obesity -- chapter 8. Bioactive peptides and polysaccharides- Setting a new trend in replacing conventional angiotensin-converting enzyme inhibitors -- Chapter 9.Natural Protease Inhibitors and their Therapeutic Potentials against SARS-CoV-2 -- Chapter 10. Telomerase and its inhibitor in cancer therapeutics: Current status and future prospective -- Chapter 11.Metal nanomaterials as enzyme inhibitors and their applications in agriculture and pharmaceutical -- Chapter 12.α-glucosidase inhibitors for diabetes/blood sugar regulation.
    Kurzfassung: This book provides an overview of the latest developments and future challenges in enzyme inhibitor research. It discusses the general enzyme inhibitory principles and mechanisms in enzyme activity regulation and application of enzyme inhibitors in different areas and sectors. The major areas of applications of enzyme inhibitors covered in this book are human health management, agriculture, food processing and research, which leads to drug discovery or enzyme activity mechanisms. The book also identifies the gaps in the existing knowledge and opens up new research ideas in this important area. Currently, most enzyme inhibitors are reported to inhibit various classes of enzymes. These enzyme inhibitors are the focus of the scientific community because they may answer an increasing array of questions in the research area of biological sciences, including biochemistry, medicine, physiology, pharmacy, agriculture, ecology etc. It also serves as a useful tool in the study of enzyme structures and reaction mechanisms and in the development of technologies in agriculture, food processing, and health management. Chapters in this book cover topics such as plant-derived inhibitors of serine proteases, pancreatic lipase (PL) inhibitors from indigenous medicinal plants, amylase inhibitors and their applications in agriculture and food processing industries and advances in silico techniques used in the study of enzyme inhibitors. The book will serve as a valuable resource for students and researchers in Life Sciences, agriculture, medicine, food processing, and allied industries. .
    Materialart: Online-Ressource
    Seiten: XII, 283 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811909320
    URL: https://doi.org/10.1007/978-981-19-0932-0
    DOI: 10.1007/978-981-19-0932-0
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 91
    Online-Ressource
    Online-Ressource
    Perspectives in Pharmacy Practice : Trends in Pharmaceutical Care (2022)
    Singapore :Springer Nature Singapore :
    Details
    Schlagwort(e): Pharmaceutical chemistry. ; Pharmacy. ; Family medicine. ; Practice of medicine. ; Hospitals Administration. ; Pharmaceutics. ; Pharmacy. ; General Practice and Family Medicine. ; Practice and Hospital Management.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction Pharmacy- Industry, Community Pharmacy, Clinical Pharmacy and Hospital Pharmacy -- Chapter 2. Pharmacy Profession - Role and Responsibility of Pharmacist in Healthcare Delivery -- Chapter 3. Pharmacist - Background, Knowledge and skills -- Chapter 4. Patients – Gaps in Knowledge, Medication Errors and its impact on outcomes, quality of life & Cost of treatments -- Chapter 5. Communication – Inter and Intra communication, Provider-patient communication perspectives and approaches, Provider competencies and communication skill, Patient competencies and communication skills, Equity in health care delivery, Patient counselling, Medication History and Patient Education -- Chapter 6. Pharmaceutical Care- WHO-FIP model, Soap analysis and Illustrative Case studies -- Chapter 7. Clinical Pharmacy Services- Drug and poison information, ward round participation, Drug- Drug/Drug food interaction, Prescription analysis, PTC activities, Formulary management and TDM services -- Chapter 8. Community Pharmacy services - Dispensing of Prescription, Home medication Review, Screening of chronic diseases, Treatments of minor ailments, monitoring of chronic disease and Maintaining of Patient profile -- Chapter 9. Hospital Pharmacy Services - Ward Pharmacy, Compounding of Prescription, Extempore Preparation, Nuclear Medicine, Narcotic drugs storage and dispensing -- Chapter 10. Ethics and Regulations- Pharmacist Oath, Drugs & Cosmetics Act 1940, Pharmacy Act 1950, Pharm D regulations, Bridge Course for Pharm Drugs and Magic Remedies Act, Pharmacy Practice Regulations 2015 and Jan Aushadhi scheme -- Chapter 11. Speciality Pharmacy Services – ADR reporting and Pharmacovigilance, Pediatrics, Geriatrics, Women during pregnancy, Cancer, Pain management and Nutrition -- Chapter 12. Medication Therapy Management – Importance and practice- Chapter 13. Over the Counter Medicine- Community Pharmacy and informed self-medication -- Chapter 14. Clinical Pharmacokinetics - ADME, Bioavailability & Bioequivalence, Dosage adjustments in CKD and Liver disease -- Chapter 15. Biotherpuetics – Monoclonal Antibodies, Biologicals, Bio generics, Biosimilar and Bio betters -- Chapter 16. Introduction to Clinical Trails and Biostatistics- Chapter 17. Introduction to Personalized Medicine and pharmacogenetics -- Chapter 18. Introduction to Pharmacoeconomics and Outcome research -- Chapter 19. Clinical Trails, Pharmacovigilance and drug safety -- Chapter 20. RCT, Systematic Reviews and Evidence based medicine.
    Kurzfassung: This comprehensive text provides information on fundamental principles of clinical practice and how these can be implemented to provide excellent treatment to the patients. The triads of health care delivery include Physicians, Pharmacist and Nurses that have distinct roles and responsibilities of patient care. Effective pharmacy practice requires an understanding of the social context within which pharmacy is practiced, recognizing the particular needs and circumstances of the users of pharmaceutical services and of pharmacy's place within health service provision. This book presents a contemporary view of pharmacy practice research covering theories, methodologies, models and techniques that are applicable. The initial chapters describe the basics of pharmacy profession and what is the key role and responsibilities of Pharmacist in health care delivery. The central part of the book illustrates the community, hospital and ethics regarding drug formulation. The last chapters cover the therapeutic aspect of pharmacy and how these can be employed to improve patient’s health care facilities.
    Materialart: Online-Ressource
    Seiten: XX, 332 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9789811692130
    URL: https://doi.org/10.1007/978-981-16-9213-0
    DOI: 10.1007/978-981-16-9213-0
    DDC: 615.19
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 92
    Online-Ressource
    Online-Ressource
    Cancer Stem Cell Markers and Related Network Pathways (2022)
    Cham :Springer International Publishing :
    Details
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical genetics. ; Medical microbiology. ; Biomedical Research. ; Biomedical Research. ; Medical Genetics. ; Medical Microbiology.
    Beschreibung / Inhaltsverzeichnis: 1. Epithelial-mesenchymal transition and cancer stem cells -- 2. The transcription factors Zeb1 and Snail induce cell malignancy and can-cer stem cell phenotype in prostate cells, increasing androgen synthesis ca-pacity and therapy resistance -- 3. ERBB signaling pathway in cancer stem cells -- 4. Functional and molecular characters of cancer stem cells through devel-opment to establishment -- 5. Microenvironment in cancer stem cells -- 6. Cancer stem cells contribute to drug resistance in multiple different ways -- 7. Abnormal glycosylation in cancer cells and cancer stem cells as a thera-peutic target.
    Kurzfassung: This book entitled “Cancer Stem Cell Markers and Related Network Path-ways” is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype. This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways. The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters. The topic of this book is particularly relevant to research in the field of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.
    Materialart: Online-Ressource
    Seiten: XIV, 156 p. 23 illus., 21 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031129742
    Serie: Advances in Experimental Medicine and Biology, 1393
    URL: https://doi.org/10.1007/978-3-031-12974-2
    DOI: 10.1007/978-3-031-12974-2
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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