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  • 1
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Water. ; Hydrology. ; Biotic communities. ; Social sciences. ; Humanities. ; Environmental management. ; Freshwater and Marine Ecology. ; Water. ; Ecosystems. ; Humanities and Social Sciences. ; Environmental Management.
    Beschreibung / Inhaltsverzeichnis: Part I. Introduction -- Chapter 1. Southern Baltic Coastal Systems Analysis: Questions, Conceptions and Red Threads -- Chapter 2. Coastal Ecosystems from a Social-Ecological Perspective -- Part II. Ecological Structures and Functions of the German Baltic Sea Coast -- Chapter 3. The Abiotic Background: Climatic, Hydrological and Geological Conditions of the Southern Baltic -- Chapter 4. Geological and Sedimentary Conditions -- Chapter 5. Environmental Conditions at the Coast: The Terrestrial Ecosystems -- Chapter 6. Environmental Conditions at the Coast: Shoreline Ecosystems -- Chapter 7. Ecosystem and Landscape Functions of the Coast: Recent Research Results -- Chapter 8: Benthic Habitats and Their Inhabitants -- Part III. Ecological Structures and Functions of Coastal Water and Offshore Ecosystems -- Chapter 9. Introducing the Ecological Aspects -- Chapter 10. Baltic Sea Aquatic Ecosystems in a Gradient from Land to Open Sea -- Chapter 11. Comparison of Abiotic Parameters and Dominant Primary Producers Between the Two Main Investigation Areas -- Chapter 12. Short-Term Variability, Long-Term Trends and Seasonal Aspects in the Darß-Zingst Bodden Chain -- Chapter 13. Carbon Fluxes/Food-Webs: Effect of Macrophytes on Food Web Characteristics in Coastal Lagoons -- Chapter 14. Ecological Structure in Benthic Habitats of Offshore Waters -- Chapter 15. Patterns of Bioturbation and Associated Matter Fluxes -- Chapter 16. Seasonal Aspects and Short-Term Variability of the Pelagic Offshore Ecosystems -- Chapter 17. Long-Term Trends of the Offshore Ecosystems -- Chapter 18. Nutrient and Limitation Regimes in Coastal Water Ecosystems -- Part IV. Combining the Aspects: Ecosystem Service Assessment -- Chapter 19. The Human Factor: Coastal Social-Ecological Systems -- Chapter 20. Introduction: The Concept of Ecosystem Service Assessment Applied to Coastal Systems -- Chapter 21. The Missing Links in Ecosystem Service Research -- Chapter 22. Eudaimonic Valuation of Cultural Ecosystem Services -- Chapter 23. Economic Valuation of Cultural Ecosystem Services -- Chapter 24. Spatial Ecosystem Service Assessment Across the Land-Sea-Interface -- Chapter 25. Temporal Changes in Aquatic Ecosystem Services Provision: Approach and Examples -- Chapter 26. Assessing Temporal Changes in Ecosystem Service Provisions: Conceiving Future Pathways -- Part V. Synthesis: Assessment as a Tool for Managing Coastal Ecosystems? -- Chapter 27. Applying the Integrated Approach -- Chapter 28. Mechanisms of Ecosystem Service Production: An Outcome of Ecosystem Functions and Ecological Integrity in Coastal Lagoons -- Chapter 29. Ecosystem Service Assessment in European Coastal and Marine Policies -- Chapter 30. Ecosystem Services and Sustainable Development: The Case for Strong Sustainability -- Chapter 31. Concluding Remarks.
    Kurzfassung: This book gives an overall analysis of the current knowledge status about structures, functions, utilization for German Baltic coast ecosystems. The main focus of this book is on the aquatic area, but land/sea interactions as well as river outfalls are included as well. Characteristic for this book is the inclusion of social science aspects. Approximately one third of its extent will be about the ecosystem services. In this segment the results of the last 6 years are presented in which a comprehensive quantification of the social relevance of ecosystems was carried out covering the entire area of the German Baltic Sea. This part builds directly on the results of scientific investigations and are in relation to social ideals. The assessment will not only be economically and ethically but also the mechanisms that are used for the valorisation of the ecosystem services will be evaluated. Both sub-areas, the classic natural science part as well as the part of social science aspects, deal with the changes caused by increasing anthropogenic influence and social (including demographic) changes. This will be among others in the sense of an exemplary historical outline. The final chapter of the synthesis therefore not only presents a summary of the level of knowledge gained and a deduction of the research needs. It further contains a presentation of the application aspects resulting from the analysis of the social relevance gained from basic scientific research. The book is aimed at scientists (and students) of natural, life and social sciences, analysing functioning and structures of coastal ecosystems with regard to sustainable use and nature protection, including aspects of coastal protection. Besides, it is thought to become a reference for all levels of decision makers and stakeholders in coastal and marine management of the Baltic and North Sea region, providing also a blueprint for system analysis respecting for societal as well as biological aspects world-wide.
    Materialart: Online-Ressource
    Seiten: XV, 387 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031136825
    Serie: Ecological Studies, Analysis and Synthesis, 246
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Human physiology. ; Neurology . ; Life sciences. ; Physiology. ; Neuroscience. ; Human Physiology. ; Neurology. ; Life Sciences. ; Animal Physiology. ; Life Sciences.
    Beschreibung / Inhaltsverzeichnis: Part I: HISTORY -- Chapter 1: Transmissible Spongiform Encephalopathy: from its beginnings to Daniel Carleton Gajdusek -- Part II: GENERAL ASPECTS OF PRIONS -- Chapter 2: The Rich Chemistry of the Copper and Zinc Sites in Cellular Prion Protein -- Chapter 3: Mammalian Prion Structures -- Chapter 4: Insoluble Cellular Prion Protein and Other Neurodegeneration-related Misfolded Protein Aggregates in the Brain of Asymptomatic Individuals -- Part III: CONVERSION AND STRAIN OF PRIONS -- Chapter 5: Prion Conversion and Deformed Templating -- Chapter 6: Prion Strain Interference -- Chapter 7: Molecular Mechanisms Encoding Strains of Prions and Prion-Like Misfolded Proteins -- Chapter 8: Cofactor Involvement in Prion Propagation -- Chapter 9: Prion Protein Conversion and Lipids -- Part IV: ENVIRONMENT AND TRANSMISSION OF PRIONS -- Chapter 10: Prions in the Environment -- Chapter 11: Environmentally Acquired Transmissible Spongiform Encephalopathy -- Chapter 12: Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion -- Chapter 13: Species Barriers in Prion Disease -- Part V: MODELLING OF PRIONS -- Chapter 14: Modeling the Cell Biology of Prions -- Chapter 15: Transgenic Mice Modelling in Prion Diseases -- Chapter 16: Stem Cell Models in Prion Research -- Chapter 17: Drosophila Models of Prion Diseases -- Part VI: HUMAN PRION DISEASES AND OTHER PATHOLOGIES -- Chapter 18: Human Sporadic Prion Diseases -- Chapter 19 Genetic Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker Diseases -- Chapter 20: Glycoform-selective Prions in Sporadic and Inherited Variably Protease-sensitive Prionopathies -- Chapter 21: The Spectrum of Tau Pathology in Human Prion Disease -- Chapter 22: Prion Protein Complex with mGluR5 Mediates Amyloid-ß Synaptic Loss in Alzheimer’s Disease -- Chapter 23: Prion and Cancers -- Chapter 24: Protective Role of Cellular Prion Protein in Tissue Ischemic/Reperfusion Injury -- Part VII: ANIMAL PRION DISEASES -- Chapter 25: Bovine Spongiform Encephalopathy -- Chapter 26: Classical and Atypical Scrapie in Sheep and Goats -- Chapter 27: Research models for studying chronic wasting disease -- Part VIII: YEAST PRIONS -- Chapter 28: Introduction to Yeast and Fungal Prions -- Chapter 29: Yeast Prions Are Folded, In-Register Parallel Amyloids Subject to Multiple Anti-prion Systems -- Part IX: DIAGNOSIS AND HUMAN PRION SURVEILLANCE -- Chapter 30: Real-time quaking-induced conversion (QuIC) assays for the detection and diagnosis of human prion diseases -- Chapter 31: Protein Misfolding Cyclic Amplification -- Chapter 32: Skin Misfolded Proteins as Biomarkers for Diagnosis of Prion and Prion-like Diseases -- Chapter 33: Diagnosis of Prion Disease: Conventional Approaches -- Chapter 34: Human Prion Disease Surveillance -- Part X: TREATMENT -- Chapter 35: Overview on Treatment of Prion Diseases and Decontamination of Prions -- Chapter 36: Gene Therapy Strategies for Prophylactic and Therapeutic Treatments of Human Prion Diseases -- Chapter 37: Immunomodulation.
    Kurzfassung: Transmissible spongiform encephalopathies (TSE), now known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains the most authoritative views about the past, present, and future of prions and prion diseases covering fresh perspectives on important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
    Materialart: Online-Ressource
    Seiten: XII, 793 p. 81 illus., 62 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031205651
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Pain medicine. ; Neurology . ; Anesthesiology. ; Neuroscience. ; Pain Medicine. ; Neurology. ; Anesthesiology.
    Beschreibung / Inhaltsverzeichnis: Introduction to Acute, Chronic, and Episodic Pain -- Inflammation and Pain -- Animal Models of Pain and Anti-inflammatory Treatments -- Inflammatory Mediators, Nociceptors, and Their Interactions in Pain -- Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons -- Sex Differences in Neuroimmune Interactions and Pain -- Neuroimmune Interactions in Itch -- Toll-like Receptors in Pain and Itch -- Immunotherapy and Pain -- Cell Therapy and Regenerative Pain Medicine - Preclinical Studies -- Cell-based Therapies in Pain Management -- Platelet-Rich Plasma and Autologous Conditioned Serum: Non-Cellular Biologic Therapies for Neuroimmune Modulation and the Treatment of Arthritis Pain -- Exercise and Diet in the Control of Inflammation and Pain -- Mechanism-Based Pain Therapies -- Neuromodulation in Pain Management -- What Patients Need to Know about Pain Therapy?.
    Kurzfassung: As lifespans increase, more people around the world find themselves victims of chronic pain. In spite of this, treatment options continue to be severely limited. Anti-inflammatory drugs can only do so much, while painkillers like opioids have led to crippling addictions and fatal overdoses. The subject of the book is the role of immune cells, including glial cells, and neuroimmune interactions in chronic pain. The book begins by examining the preclinical and clinical evidence supporting the involvement of non-neuronal cells in chronic pain. It discusses the interactions between non-neuronal cells and neurons in the regulation of chronic pain. It then presents the implications of these findings, including promising and emerging treatments such as specialized pro-resolving mediators (SPMs, such as resolvins and protectins), immune cell therapy, and complementary and alternative medicine, as well as neuromodulation and regenerative medicine, which may prove to be the turning point for hundreds of millions of patients world-wide who struggle to escape from the shadow of chronic pain. The book presents ground-breaking research that will alter current perspectives on chronic pain.
    Materialart: Online-Ressource
    Seiten: X, 364 p. 45 illus., 41 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031292316
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Cardiovascular system. ; Physiology. ; Cardiology. ; Clinical biochemistry. ; Biomedical Research. ; Cardiovascular Physiology. ; Cardiology. ; Medical Biochemistry.
    Beschreibung / Inhaltsverzeichnis: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.
    Kurzfassung: This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease. From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.
    Materialart: Online-Ressource
    Seiten: XVIII, 452 p. 71 illus., 54 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031149528
    Serie: Advances in Biochemistry in Health and Disease, 24
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Schlagwort(e): Neurosciences. ; Cognitive neuroscience. ; Psychobiology. ; Human behavior. ; Sociology. ; Neuroscience. ; Cognitive Neuroscience. ; Behavioral Neuroscience. ; Sociology.
    Beschreibung / Inhaltsverzeichnis: Molecular imaging of the human emotion circuit -- The neurocognitive mechanisms of unconscious emotional responses -- Social and Affective Neuroscience of Embodiment -- The neuroscience of beauty -- Mirror Neurons … in action: ERPs and neuroimaging evidence -- Sex differences in social cognition -- Development of morality and emotional processing -- Trust in Social Interaction: From Dyads to Civilizations -- The time has come to be mindwanderful: Mind wandering and the intuitive psychology mode -- Social Cognition development and socio affective dysfunction in childhood and adolescence -- Clinical neuroscience meets second-person neuropsychiatry -- EEG and ERPs in the study of Language and Social Knowledge -- fMRI and fNIRS methods for social brain studies: hyperscanning possibilities -- Modulating the Social and Affective Brain with transcranial stimulation techniques -- What our eyes can tell us about our social and affective brain? -- Facial EMG – Investigating the interplay of facial muscles and emotions.
    Kurzfassung: This Open Access book presents the current state of the art knowledge on social and affective neuroscience based on empirical findings. This volume is divided into several sections first guiding the reader through important theoretical topics within affective neuroscience, social neuroscience and moral emotions, and clinical neuroscience. Each chapter addresses everyday social interactions and various aspects of social interactions from a different angle taking the reader on a diverse journey. The last section of the book is of methodological nature. Basic information is presented for the reader to learn about common methodologies used in neuroscience alongside advanced input to deepen the understanding and usability of these methods in social and affective neuroscience for more experienced readers.
    Materialart: Online-Ressource
    Seiten: XXXIII, 302 p. 55 illus., 48 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031086519
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Metabolism Disorders. ; Genetics. ; Cardiovascular system. ; Physiology. ; Biomedical Research. ; Metabolic Disease. ; Genetics and Genomics. ; Cardiovascular Physiology.
    Beschreibung / Inhaltsverzeichnis: An overview of genome editing in cardiovascular and metabolic diseases -- Bioinformatics research methodology of genome editing in cardiovascular and metabolic diseases -- Online databases of genome editing in cardiovascular and metabolic diseases -- Application of systems biology for genome editing involved in regulating of cardiovascular and metabolic diseases -- Bioinformatics for reducing off-targets in cardiovascular and metabolic diseases -- Genome editing and cardiac regeneration -- Genome editing and myocardial development -- Genome editing and heart failure -- Genome editing and pathological cardiac hypertrophy -- Genome editing and cardiac remodeling -- Genome editing and diabetic cardiomyopathy -- Genome editing and cardiac arrhythmias -- Genome editing and atrial fibrillation -- Genome editing and muscle atrophy -- Genome editing and obesity -- Genome editing and fatty liver -- Genome editing and diabetes -- Genome editing and gout -- Genome editing and protein energy malnutrition -- Genome therapy and cardiovascular diseases -- Therapeutics in metabolic diseases -- Gene editing and human iPSCs in cardiovascular and editing diseases -- Prospective advances in genome editing investigation.
    Kurzfassung: This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing. Genome editing is a genetic engineering technique precisely modified specific target genes of organism genome, which has been applied to basic theoretical research and production applications from plants and animals to gene therapy of human beings. Cardiovascular and metabolic diseases have become major factors affecting human health worldwide. This book contains information about bioinformatics, genome editing in cardiovascular diseases, genome editing in metabolic diseases and therapeutic effects. It will be useful for biologist, cardiologist, cardiovascular surgeons, endocrinologist, internists, nurses, undergraduate and graduate students in medicine and cell biology and others interested in cardiovascular and metabolic medicine.
    Materialart: Online-Ressource
    Seiten: XII, 339 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789811956423
    Serie: Advances in Experimental Medicine and Biology, 1396
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Reproduction. ; Physiology. ; Pollution. ; Freshwater and Marine Ecology. ; Reproductive Physiology. ; Pollution.
    Beschreibung / Inhaltsverzeichnis: 1. Pesticide and xenobiotic metabolism in aquatic organisms -- 2. Endocrine disrupting activity of xenobiotics in aquatic animals -- 3. Water contamination through xenobiotics and their toxic effects on aquatic animals -- 4. Cypermethrin induced reproductive toxicity in zebrafish: biochemical and molecular perspective -- 5. Impact of Pesticides Application on Aquatic Environments And Biodiversity -- 6. Impact of microplastics on reproductive and physiological aspects of aquatic inhabitants -- 7. The Impact of Xenobiotics in Development & Reproduction of fresh water Fishes -- 8. Mixtures and Reproduction in Aquatic Organisms – benefits and challenges -- 9. Phytoestrogens as Endocrine-Disrupting Agents In Aquaculture -- 10. A Proteomic Approach to Studying the Effects of Xenobiotics on Aquatic Living Organisms -- 11. Role of Cytochrome P450 in xenobiotic metabolism in fishes -- 12. Pharmacokinetic-Pharmacodynamic modelling of Xenobiotics: Fate and effect in Aquatic Animals -- 13. Occurrence of xenoestrogen alkylphenols (Octylphenols and Nonylphenol), and its impact on the aquatic ecosystem -- 14. Xenobiotics' effect on fish reproduction and development -- 15. Scientometric analysis of ecotoxicological investigations of xenobiotics in aquatic animals -- 16. Toxic effects of nanomaterials on aquatic animals and their future prospective -- 17. Microplastic Contamination in Aquatic organisms: An Ecotoxicological perspective -- 18. Effect of xenobiotics and their degradation in aquatic life -- 19. Transcriptome analysis of aquatic species exposed to endocrine disruptors -- 20. Fundamentals of genotoxicity and antiparasitic drugs associated with genotoxicity in fish -- 21. Endocrine disrupting compounds (EDCs) as emerging aquatic contaminants: Emphasis on Reproduction and Development.
    Kurzfassung: This book summarizes the latest understanding of the impact of xenobiotics on the developmental and reproductive processes of aquatic animals, particularly nektonic forms, which comprise an important group of aquatic ecosystems. Aquaculture is quickly becoming the largest contributor of fish protein for human consumption. As the aquaculture business expands, farmed fish will be exposed to more environmental toxins, necessitating the use of chemical therapeutic drugs for fish. This book brings together experts on the regulation of environmental toxins and food chemicals from around the world, as well as researchers looking into the metabolism and disposal of foreign chemicals (xenobiotics) in fish species. The impact of xenobiotics on reproductive and developmental biology of all living forms has become of prime importance at the current time. As the effect of these xenobiotics on aquatic animals is an emerging area for research and development, several groups across the world are working on these aspects, targeting different groups of fishes in both marine and freshwater ecosystems. This collective work highlights several key and updated recent aspects of different types of xenobiotics entering aquatic ecosystems, impacts of these agents on reproductive physiology, developmental biology, breeding biology, hormonal imbalance, aquatic ecology, and pollution on the aquatic ecosystem. The unique aggregation of different types of stressors to aquatic animals under a single volume will be a useful reference for readers, including scientists, teachers, students, researchers and policymakers and those involved in aquaculture and environment conservation.
    Materialart: Online-Ressource
    Seiten: XXIX, 427 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819912148
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Schlagwort(e): Neurosciences. ; Neurology . ; Pharmacology. ; Neuroscience. ; Neurology. ; Pharmacology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Why study Drug Resistant Epilepsy? -- Chapter 2: Pharmacoresistance in Epilepsy -- Chapter 3: Experimental models for the study of drug-resistant epilepsy -- Chapter 4: On Complexity and Emergence: Linking the Hypotheses of Pharmacoresistance in Epilepsy -- Chapter 5: Role of High-Frequency Oscillation Networks in Managing Pharmacoresistant Epilepsy -- Chapter 6: Transporter hypothesis in pharmacoresistant epilepsies. Is it at the central or peripheral level? -- Chapter 7: Changes in Targets as an Explanation for Drug Resistance in Epilepsy -- Chapter 8: Cellular and molecular mechanisms of neuroinflammation in drug-resistant epilepsy -- Chapter 9: Contribution of the antiepileptic drug administration regime to avoid the development and/or establishment of pharmacoresistant epilepsy -- Chapter 10: Pharmacogenetics in Epilepsy and Refractory Epilepsy -- Chapter 11: Seizures Induce Hypoxia or Hypoxia Induces Seizures. A Perverse Relationship that Increases the Risk of SUDEP -- Chapter 12: Neonatal excitotoxicity triggers degenerative processes related to seizure susceptibility and pharmacoresistance -- Chapter 13: Cerebrovascular remodeling and the role of vascular endothelial growth factor in the epileptic brain and pharmacoresistance -- Chapter 14: The Role of JNK3 in Epilepsy and Neurodegeneration -- Chapter 15: Application of proteomics in the study of molecular markers in epilepsy -- Chapter 16: GABAergic neurotransmission abnormalities in pharmacoresistant epilepsy: experimental and human studies -- Chapter 17: Genes involved in pharmacoresistant epilepsy -- Chapter 18: Drug-resistant Epilepsy and the Influence of Age, Gender and Comorbid Disorders -- Chapter 19: Indications for Intracerebral Recording in Candidates for Epilepsy Surgery -- Chapter 20: On the Development of New Drugs for the Treatment of Drug Resistant Epilepsy: An Update on Different Approaches to Different Hypotheses -- Chapter 21: Physical exercise as a strategy to reduce seizure susceptibility -- Chapter 22: Ketogenic Diet and Drug-resistant Epilepsy -- Chapter 23: Modulating P-glycoprotein Regulation as a Therapeutic Strategy for Pharmacoresistant Epilepsy -- Chapter 24: Vagus Nerve Stimulation for Intractable Seizures -- Chapter 25: Non Invasive Brain Stimulation as a potential Therapeutic Procedure in drug-resistant epilepsy -- Chapter 26: Effects of transcranial focal electrical stimulation via concentric ring electrodes on seizure activity.
    Kurzfassung: This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.
    Materialart: Online-Ressource
    Seiten: XV, 596 p. 84 illus., 79 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031365263
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical education. ; Anatomy. ; Virtual reality. ; Augmented reality. ; Biomedical Research. ; Medical Education. ; Anatomy. ; Virtual and Augmented Reality.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Pandemic-Era Digital Education: Insights from an Undergraduate Medical Programme -- Chapter 2. Use of Lt Systems in Large Class Lab Delivery -- Chapter 3. COVID-19 Adaptations for Biomedical Teaching and Assessment Within the Undergraduate Dental Curriculum -- Chapter 4. One Size Does Not Fit All in Remote Anatomy Teaching -- Chapter 5. From Lecture Halls to Zoom Links: How Can Educational Theory Help Us to Deliver Effective and Engaging Teaching in an Online Environment? -- Chapter 6. Collaborative, Two-Directional Live Streaming to Deliver Hands-on Dissection Experience during the COVID-19 Lockdown -- Chapter 7. Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations -- Chapter 8. Virtual Reality for Anatomy and Surgical Teaching -- Chapter 9. Can Synchronous Online Near-Peer Teaching Offer the Same Benefits as the Face-to-Face Version When Used in Clinical Neuroanatomy Education? -- Chapter 10. COVID-19 Adaptations with Virtual Microscopy -- Chapter 11. The Challenges of Visualisation During Delivery and Assessment of Clinical Teaching Under COVID-19: A Reflective Account of Problem Solving -- Chapter 12. Not for Room 101.
    Kurzfassung: This book focuses on the challenges to biomedical education posed by the lockdowns and restrictions to on campus teaching brought about by the COVID-19 pandemic and highlights the tools and digital visualization technologies that have been successfully developed and used for remote teaching. Biomedical education for science, medical, dental and allied health professionals relies on teaching visual and tactile knowledge using practice-based approaches. This has been delivered for decades via on-campus lectures, workshops and laboratories, teaching practical skills as well as fundamental knowledge and understanding. However, the arrival of the COVID-19 pandemic meant that education across the globe had to pivot very quickly to be able to deliver these skills and knowledge in a predominantly online environment. This brought with it many challenges, as Higher Education staff, had to adapt to deliver these visual subjects remotely. This book addresses the challenges and solutions faced by Higher Education staff in teaching visual content in distance education. Chapters include literature reviews, original research, and pedagogical reflections for a wide range of biomedical subjects, degrees such as medicine, dentistry and veterinary sciences with examples from undergraduate and postgraduate settings. The goal of the book is to provide a compendium of expertise based on evidence gathered during the COVID-19 pandemic, as well as reflections on the challenges and lessons learned from this dramatic shift in teaching. It also presents new examples of best practices that have emerged from this experience to ensure that they are not lost as we return to on-campus learning in a new era of biomedical teaching. This book will be of interest to anyone looking for a helpful reference point when designing online or blended teaching for visual practice-based subjects.
    Materialart: Online-Ressource
    Seiten: X, 228 p. 56 illus., 52 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031171352
    Serie: Advances in Experimental Medicine and Biology, 1397
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Cytology. ; Biomedical Research. ; Cell Biology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Magnetic Field Parameters and Biological Sample Differences that Lead to Differential Bioeffects -- Chapter 2. Static Magnetic Field Direction-induced Differential Biological Effects -- Chapter 3. Magnetic Properties of Biological Samples -- Chapter 4. Molecular Mechanisms for Electromagnetic Field Biosensing -- Chapter 5. Controlling Cell Membrane Potential with Static Non-uniform Magnetic Fields -- Chapter 6. Impact of Static Magnetic Fields on Cells -- Chapter 7. Impact of Static Magnetic Fields on Microorganisms, Plants and Animals -- Chapter 8. Static Magnetic Fields on Human Bodies -- Chapter 9. Potential Applications of Static Magnetic Fields in Cancer Treatment -- Chapter 10. Effects of Static Magnetic Fields on Diabetes and Its Complications -- Chapter 11. Impacts of Static Magnetic Field on Bone Health -- Chapter 12. Effects of Static Magnetic Fields on the Immune System -- Chapter 13. Biological Effects of Static Magnetic Fields on the Nervous System -- Chapter 14. The Biological Effects of Long-term Static Magnetic Field Exposure -- Chapter 15. Prospects, Pitfalls, and Opportunities for Human Static Magnetic Field Therapy.
    Kurzfassung: The book summarizes the emerging topic about the effects of SMF on biological samples ranging from single molecules, subcellular compartments, and cells to whole organisms. It also discusses the potential application of SMF in clinical treatment of cancer, pain, diabetes and other diseases. With the development and growing popularity of modern appliances like MRI in hospitals, the potential impact of magnetic fields on human health is invoking increasing concerns. At the same time, SMF has been explored in the treatment of tumor and other diseases for decades. Nevertheless, there are still some reservations and uncertainties about these treatments, which are largely due to the differential biological effects reported in the literature. These experimental inconsistencies are mainly caused by variations such as different magnetic field types, intensities, treatment time, as well as biological samples examined. The second edition added eight new chapters about new progress in this field including impacts of SMFs, magnetism of biomolecules, and potential of SMFs in the management of bone, pain, diabetes, and immune systems. This volume will help clarify some dilemmas in this field and encourage further investigations in order to achieve a better understanding of the biological effects of SMF, aiming for a rational application of SMF in clinical therapy in the near future. The book is useful for scientists, doctors, and students who are interested in magnetic fields and life sciences.
    Materialart: Online-Ressource
    Seiten: XV, 420 p. 1 illus. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9789811988691
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 11
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Neurology . ; Developmental neurobiology. ; Neuroscience. ; Neurology. ; Development of the Nervous System.
    Beschreibung / Inhaltsverzeichnis: The development of the cerebellum: from the beginnings -- Part I: Responsibilities and liabilities -- Chapter2. The embryology and anatomy of the cerebellum -- Chapter 3. Cellular and genetic programs underlying cerebellum development -- Chapter 4. Early Purkinje Cell Development and the Origins of Cerebellar Patterning. - Chapter 5. Development of the Fish Cerebellum. -Chapter 6. Cerebellar developmental disorders and cerebellar nuclei -- Chapter 7. Motor circuit abnormalities during cerebellar development -- Chapter8. Developmental disorders of the cerebellum and neurotrophic factors -- Chapter9. Apoptosis, Autophagy, and Unfolded Protein Response and Cerebellar Development -- Chapter10. The ubiquitin proteasome system and cerebellar developmental disease -- Chapter11. Epigenetics and Cerebellar Neurodevelopmental Disorders -- Chapter12.. Hormonal regulation of cerebellar development and its disorders -- Chapter13. Infections of the Cerebellum -- Chapter14. Neuroimmune mechanisms of cerebellar development and its developmental disorders -- Chapter15. Teratogenic influences on cerebellar development -- Chapter16. Primary pediatric brain tumors of the posterior fossa -- Chapter17. Primary pediatric brain tumors of the posterior fossa -- Chapter18. Can cerebellar neurodevelopmental disorders affect behavioral disorders or vice versa -- Chapter19. Neurodevelopmental disorders of the cerebellum: autism spectrum disorder -- Chapter20. Congenital cerebellar disease -- Chapter21. Clinical features, assessment, and management of patients with developmental and other cerebellar disorders -- Chapter22. Epidemiology of cerebellar disorders -- Chapter23. Cerebellar transplantation: a potential model to study repair and development of neurons and circuits in the cerebellum. - Chapter 24. Non-coding RNAs and cerebellar development. - Chapter 25. Defining the Cerebellar Cytoarchitecture Using MRI. .
    Kurzfassung: This updated reference covers diverse aspects of cerebellar development from a full range of viewpoints, including the epidemiology of cerebellar genetic disorders, developmental anatomy, cell biology, genetics, epigenetics, infectious diseases, and mechanisms involved in the regulation of cell fate, while also focusing on information that is relevant to clinicians caring for patients with cerebellar disorders. The chapters are written by experts in the field of cerebellar development, and the chapters cover diseases related to the cerebellum, along with their epidemiology, clinical features, assessment, and management. In addition to updating the content to cover the significant developments in the field since the first edition, the second edition will include new chapters on Non-Coding RNAs and Cerebellar Development, Development of the Fish Cerebellum, the Role of nNOS/NO on Cerebellar Development in Health and Disease, and rehabilitation in cerebellar ataxia. The effect of the COVID-19 on the cerebellum has been included in related chapters. Development of the Cerebellum from Molecular Aspects to Diseases, 2nd edition, is designed to be valuable reference for both neuroscientists and clinicians.
    Materialart: Online-Ressource
    Seiten: IX, 639 p. 116 illus., 88 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031231049
    Serie: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 12
    Schlagwort(e): Medicine Research. ; Biology Research. ; Biology. ; Neurosciences. ; Biotechnology. ; Drug delivery systems. ; Biomedical Research. ; Biological Sciences. ; Neuroscience. ; Biotechnology. ; Drug Delivery.
    Beschreibung / Inhaltsverzeichnis: Chapter 1.Deciphering New Drug Targets in Alzheimer’s Disease -- Chapter 2. Novel Therapeutic Targets for Treating Alzheimer’s Disease -- Chapter 3. Modified Investigation Tools and Techniques Useful in Alzheimer’s Disease Research -- Chapter 4. Dual Specificity Tyrosine Phosphorylation Regulated Kinase1A (DYRK1A) Inhibitors: The Quest for a Disease-Modifying Treatment for Alzheimer’s Disease -- Chapter 5. β-secretase as a primary drug target of Alzheimer disease: Function, Structure, and Inhibition -- Chapter 6. Endocrine Receptors: The Potential Therapeutic Targets for Alzheimer’s -- Chapter 7. Calcium Channels as a Potential Therapeutic Target for Alzheimer’s Disease -- Chapter 8. Traversing Through the Trajectory of Pathogenic Astrocytes in Alzheimer’s Disease -- Chapter 9. Targeting Mitochondrial Dynamics as a Restorative Approach in the Treatment of Alzheimer’s Disease -- Chapter 10. Epigenetic Therapy for Alzheimer’s Disease -- Chapter 11. Exploring the Diverse Roles of GSK-3ß Kinase in Alzheimer’s Disease -- Chapter 12. Role of Target Fishing in Discovery of Novel Anti-Alzheimer’s Agents: In Silico Applications -- Chapter 13. Multi-Target Directed Ligand Approach in Anti-Alzheimer’s Drug Discovery -- Chapter 14. Investigating the Role of Tau Proteins in Alzheimer’s Disease-From Typical Functioning MAPs to Aberrant Fibrillary Deposits in the Brain -- Chapter 15. The Overview of Drugs Used in Alzheimer’s Disease and Their Molecular Targets.
    Kurzfassung: This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.
    Materialart: Online-Ressource
    Seiten: XV, 381 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819926572
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 13
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical genetics. ; Life sciences. ; Cytology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Life Sciences. ; Cell Biology. ; Internal Medicine.
    Beschreibung / Inhaltsverzeichnis: Part I. Search for novel tumor epitopes related to carbohydrates -- Chapter 1.1. The ganglioside structures: chemistry and biochemistry -- Chapter 1.2. Fucosylated proteins as cancer biomarkers -- Part II. Assembly of glycoconjugates -- Chapter 2.1. Siglec-7 and synthetic sialylpolymer -- Chapter 2.2. Role of Sialyl-Tn antigen in Cancer Metastasis -- Chapter 2.3. Insights into the Role of Chondroitin Sulfate in Cancer -- Part III. Signaling pathways modulated by glycosylation -- Chapter 3.1. Significance of FUT8in pancreatic cancer and others -- Chapter 3.2. Effects of Bullfrog sialic acid-binding lectin in cancer cells -- Part IV. Interaction between carbohydrate and carbohydrate-recognizing molecules -- Chapter 4.1. Opposite functions of mono- and disialylated glycosphingolipids on the membrane of cancer cells -- Chapter 4.2. Tumor progression through interaction of mucins with lectins and subsequent signal transduction -- Part V. Clinical trials targeting glycosignals -- Chapter 5.1. Immunotherapy of Neuroblastoma Targeting GD2 and Beyond.
    Kurzfassung: This book, now in an extensively revised second edition, provides a comprehensive summary of the latest knowledge regarding glycosignals and a thorough analysis of their involvement in not only cancers but also other refractory conditions such as chronic inflammatory disorders. Many relevant topics are covered, including the search for novel tumor epitopes related to carbohydrates, the assembly of glycoconjugates, the modulation of signaling pathways by glycosylation, and interactions between complex carbohydrates and their recognition molecules. The role of various research approaches, for example advanced mass spectrometry, high-resolution imaging, and bioinformatics, is closely examined, and the results of novel therapeutic trials targeting glycosignals are discussed. The book will be essential reading for students and young researchers with an interest in glycoscience. In presenting new results and approaches and identifying areas for future research, it will also be of benefit for specialists in the field.
    Materialart: Online-Ressource
    Seiten: VI, 238 p. 1 illus. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9789811977329
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 14
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Invertebrates. ; Biotic communities. ; Biodiversity. ; Applied ecology. ; Water. ; Hydrology. ; Freshwater and Marine Ecology. ; Invertebrate Zoology. ; Ecosystems. ; Biodiversity. ; Applied Ecology. ; Water.
    Beschreibung / Inhaltsverzeichnis: Preface -- Chapter 1: Evolution of Bilateria from a Meiofauna Perspective – Miniaturization in the Focus -- Chapter 2: Meiofauna Shaping Biogeochemical Processes -- Chapter 3: Meiofauna and Biofilms – the Slimy Universe -- Chapter 4: Meiofauna Meets Microbes: Chemosynthetic Symbioses -- Chapter 5: Marine Meiofauna Diversity and Biogeography – Paradigms and challenges -- Chapter 6: Freshwater Meiofauna – a Biota with Different Rules? -- Chapter 7: Hidden Players – Meiofauna Mediates Ecosystem Effects of Anthropogenic Disturbances in the Ocean -- Chapter 8: Deep-Sea Meiofauna – a World of its Own or Deeply Connected? -- Chapter 9: Polar Meiofauna – Antipoles or Parallels? -- Chapter 10: Cave Meiofauna - Models for Ecology and Evolution -- Chapter 11: Meiofauna – Adapted to Life at the Limits -- Concluding Remarks -- Index.
    Kurzfassung: Since research on meiobenthos was last compiled in a textbook (2008/2009), the number of theoretical and applied studies has been growing rapidly. Supported by new methods and digital evaluation, meiobenthology has developed into a wide field, with more and more researchers studying cross-disciplinary aspects. New perspectives were summarized in a booklet (2019) to draw attention to promising research directions. The present book, written by leading experts, is a compilation of new thinking, data, methods and approaches in many relevant fields of recent meiobenthos research. The topics addressed range from bacteria and biofilms to globally changing processes, from polar regions to the deep-sea and from freshwater ecosystems to the ocean. So, this book is not simply another meiobenthos textbook - it is an attempt to identify new horizons in meiobenthos research, driven by the vision of advancing knowledge and understanding of benthic ecosystems.
    Materialart: Online-Ressource
    Seiten: XII, 407 p. 49 illus., 39 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031216220
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 15
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Neurosciences. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry.
    Beschreibung / Inhaltsverzeichnis: 1.How Immune-inflammatory processes link neurodegenerative and psychiatric disorders -- 2.Gut-Microbiota-Brain Axis: pathophysiological mechanism in neuropsychiatric disorders -- 3.Microbiome- induced autoimmunity and novel therapeutic intervention -- 4.The key role of microlia and circulating monocytes in etipathology neuropsychiatric disorders -- 5.Neuro-immuno-epigenetics of prenatal psychological stress -- 6.C-reactive protein (CRP): a potent inflammation biomarker in psychiatric disorders -- 7.Neuroinflammation, neurognesis and neuroprotection in schizophrenia -- 8.Autoimmue psycosis: concept, clinical manifestation and management -- 9.Stress, autonomic nervous system and kynurenine pathway in major depression -- 10.Brain-gut-microbiome axis in major depression : novel therapeutic approach -- 11.Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder -- 12.Neuroimmaging of inflammation in depression and anxiety disorders -- 13.Neuroinflammation and immune-kynureinine pathway in anxiety disorders -- 14.Inflammatory-mediated responses in development of neurogeneartive diseases -- 15.The connection between gut-brain axis and PTSD -- 16.Eating disorders : Gut microbiota-immune-brain interactions -- 17.Sleep-immune crosstalk and sleep disorders -- 18.Obsessive-compulsive disorder: immuno-inflammatory disorder? -- 19.Cytokine, neuroinflammation and neurodeneration in Alzheimer’s disease -- 20.Molecular imaging of neuroinflammation in Alzheimer's disease and MCI -- 21.The role of N-Methyl-D-Aspartate Receptor Neurotransmission and mictobiota in Alzheimer’s disease -- 22.Neuroglial activation and neuroinflammation in the brain of patients with autism -- 23.Suicide and inflammation -- 24.Anti-inflammatory effect of Traditional Chinese Medicine on the concept of Mind-body interface -- 25.Anti-inflammatory therapy as a promising target in neupsychiatric disorders.
    Kurzfassung: This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
    Materialart: Online-Ressource
    Seiten: XVII, 554 p. 28 illus., 20 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789811973765
    Serie: Advances in Experimental Medicine and Biology, 1411
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 16
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Neurophysiology. ; Gastroenterology. ; Neuroscience. ; Neurophysiology. ; Gastroenterology.
    Beschreibung / Inhaltsverzeichnis: Tools for optogenetic probing of nociceptive pathways; Monitoring activity -- An open science model to accelerate the generation, implementation and distribution of optogenetics and viral tools -- Vagal neuroinflammation accompanying respiratory viral infection: An overview of mechanisms and possible clinical significance -- Stress-induced Visceral Analgesia: Concept and Pathways -- Evidence of early life stress exposure and epigenetic modifications in functional chronic pain disorders -- EPIGENETIC REGULATION OF STRESS-INDUCED VISCERAL PAIN -- The biomechanics and mechanotransduction in visceral nociception -- VISCERAL NOCICEPTION IN GASTROINTESTINAL DISEASE -- Epithelial-Neuronal Communication in Visceral Pain -- Physiological Mechanisms Underpinning Heightened Perception of Visceral Afferent Signalling in Irritable Bowel Syndrome -- A fentanyl analogue that activates u-opioid receptors in acidified tissues inhibits colitis pain without opioid side effects -- Signalling in the Gut -- Translating colonic sensory afferent peripheral mechanosensitivity into the spinal cord dorsal horn -- Translating colonic afferent peripheral sensitivity into the spinal cord dorsal horn -- Neuron-Microglia Dynamic Duo in Chronic Abdominal Pain -- Pre-clinical Models of Endometriosis -- Spinal afferent innervation of the uterus -- Post-infectious bladder hypersensitivity in the development of Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS).
    Kurzfassung: The chapters in this book are based on the Visceral Pain conference in Adelaide, Australia, under the auspices of the International Federation for Neurogastroenterology and Motility in 2021. This is one of the hottest fields of science and includes mechanisms involving how the microbiome communicates with the brain and how, when disordered, these mechanisms contribute to clinical diseases such as Irritable Bowel Syndrome and Inflammatory Bowel Disease. Researchers from around the globe presented their latest findings as a review of the current state of the art in the field from both the clinical and scientific points of view. These systems are now appreciated as being critical for shaping our well-being and their disorders underlie chronic clinical conditions of significant morbidity and mortality. The author team includes long-established authorities who significantly contributed to the advances in visceral pain research over the past two decades and the new generation that will continue to contribute to advancing our understanding of the field.
    Materialart: Online-Ressource
    Seiten: VIII, 255 p. 37 illus., 33 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031257025
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 17
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Neuropsychology. ; Psychiatry.
    Beschreibung / Inhaltsverzeichnis: Part 1: Considering sex and gender in research studies -- Sex and Gender Science -- Best practices in the study of sex? -- Best practices in the study of Gender Differences -- The special case of a lack of sex differences – the naked mole rat? -- Lateralization and -- Part 2: Sex differences in cognitive and mental health across the lifespan -- Depression -- Schizophrenia -- Immune and neurodevelopmental disorders – autism? -- Social Cognition -- Cognition and cognitive ageing -- Part 3: Diseases of the brain and relevance of sex -- Epilepsy -- Stroke -- AD -- Parkinson’s -- Multiple Sclerosis.
    Kurzfassung: Does sex matter when it comes to brain function? This volume attempts to answer this very important question which is of relevance to the disciplines of psychology, neuroscience, psychiatry and neurology. Understanding how brain function and resultant behaviors may differ between the sexes impacts upon our knowledge of the pathology and development of treatments for various neurological and psychiatric disorders, particularly those that show significant sex differences in either prevalence and/or manifestation of symptoms. This volume covers three main themes of research into sex differences in basic neurobiology, psychology, preclinical research and clinical research. It begins by exploring our understanding of sex and gender in relation to both animal and human behaviors and discusses the relevance, and importance, of considering sex and gender when conducting research into brain function and behaviors. The second theme focuses on how sex and gender influence mental health and considers the impact of our immune system and the changes that occur with ageing. Finally, the third aspect focuses on examples of neurological disorder which show sex differences in terms of their aetiology and/or symptomology and considers the relevance in the development of treatment for these disorders including dementia, stroke and multiple sclerosis. This volume is of considerable interest to mental health and neurology professionals, including psychiatrists, neurologists, nurses, allied health clinicians and pharmacists. It is also helpful and important for preclinical researchers working in neuroscience, psychopharmacology and reproductive endocrinology.
    Materialart: Online-Ressource
    Seiten: X, 373 p. 70 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031267239
    Serie: Current Topics in Behavioral Neurosciences, 62
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 18
    Schlagwort(e): Neurosciences. ; Neurology . ; Pharmaceutical chemistry. ; Cognitive neuroscience. ; Neuroscience. ; Neurology. ; Pharmaceutics. ; Cognitive Neuroscience.
    Beschreibung / Inhaltsverzeichnis: Part I: Basic Science of Cerebellum and Ataxias -- Functional anatomy of the cerebellum -- Cerebellar physiology -- Cerebellar biochemistry/pharmacology -- Genetics of dominant ataxias -- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics -- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches -- Ion Channel Genes and Ataxia -- Part II: Biomarkers and tools of trials -- How to Design a Therapeutic Trial in SCAs -- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers -- Clinical rating scales for ataxia -- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding -- Cerebellar learning in the prism adaptation task -- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias -- Part III: Autosomal Dominant Cerebellar Ataxias -- Riluzole in progressive cerebellar ataxias -- ASOs against ATXN2 in preclinical and phase 1 trials -- Antisense oligonucleotide therapy against SCA3 -- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities -- Experimental neurotransplantation for cerebellar ataxias -- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside -- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia -- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias -- Physical therapy in Cerebellar Ataxia -- Part IV: Autosomal Recessive Cerebellar Ataxias -- Recent advances on therapeutic approaches for Friedreich’s Ataxia -- Therapeutic use of interferon gamma in Friedreich ataxia -- Metabolic treatments of cerebellar ataxia -- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome -- Part V: Sporadic Ataxias -- Therapeutic strategies in immune-mediated cerebellar ataxias -- Coenzyme Q10 in MSA -- State of the Art and History of Therapeutics in Ataxias.
    Kurzfassung: Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
    Materialart: Online-Ressource
    Seiten: XI, 727 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031243455
    Serie: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 19
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Microbiology. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Freshwater and Marine Ecology. ; Microbiology. ; Environmental Engineering/Biotechnology.
    Beschreibung / Inhaltsverzeichnis: 1. Marine Biotechnology: A Frontier for the Discovery of Nutraceuticals, Energy, and Its Role in Meeting 21st Century Food Demands -- 2. Biotechnological Utilization of the Marine Environment for Food, Drugs and Energy -- 3. Grouper Hybridization: An Effective Biotechnological Tool for Food Security -- 4. The Application of Molecular Markers to Fish Breeding and Aquaculture -- 5. Aquaculture and Applications of Green Seaweeds of the Genus Caulerpa J.V. Lamouroux, 1809 -- 6. Potential and Challenges of Sea Cucumber Holothuria Scabra Mariculture in Sabah, Malaysia -- 7. Sea Cucumber (Echinodermata: Holothuroidea) Species Diversity on the West Coast of Sabah, Malaysia -- 8. Sea Cucumbers: Source of Nutritional, Medicinal, and Cosmeceutical Products -- 9. Marine Biotechnology and its Applications in Drug Discovery -- 10. Bacteriophage as Therapeutic Strategy Against Pathogenic Vibrio -- 11. Bacterial Diversity in the Marine Environment and the Cutting-edge Tools for Isolation, Identification, and Characterization of the Marine Microbiome -- 12. Biotechnological Applications of Jellyfish-Derived Products -- 13. Application of Biotechnology in White Syndrome Coral Disease Identification -- 14. The Synergy of Remote Sensing in Marine Invasion Science -- 15. The Utilization of Agro-based Wastes by Marine Phototrophic Microbes -- 16. Artificial Intelligence Methods in Marine Biotechnology.
    Kurzfassung: This contributed volume covers the applications of marine biotechnology for food, drugs and energy production using marine resources. It introduces many aspects of marine biotechnology, including bioenergy, pharmaceutical development, food security from mariculture, pollution handling, legal issues and conflicts. Information in the book is accompanied by clear images, flow charts, quantitative and qualitative data. Marine biotechnology is essential for realizing the previously untapped potential of marine bio-resources. These resources are used to develop innovative goods and procedures that aid in the global management of food, energy, and disease management. The development of innovative tools and solutions for more sustainable marine environmental management is another important section of this title. This reference book is of interest to teachers, researchers, and climate change scientists. It serves as an additional reading material for college, undergraduate, and graduate students of marine science and aquaculture. This is also a good research guide for food and fishing industry scientists.
    Materialart: Online-Ressource
    Seiten: XIII, 354 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819906246
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 20
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Neuropsychology. ; Neurology . ; Neuroscience. ; Neuropsychology. ; Neurology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Understanding the Mechanisms of Dendritic Arbor Development: Integrated Experimental and Computational Approaches -- Chapter 2: Autophagy Mechanisms for Brain Recovery. Keep It Clean, Keep It Alive -- Chapter 3: Environmental enrichment and functional plasticity in the hippocampus, an update on the mechanisms involved -- Chapter 4: Translatable Models of Brain and Cognitive Reserve -- Chapter 5: Cognitive Reserve: A Life-Course Perspective -- Chapter 6: Neural Correlates of Brain Reserve: A Neuroimaging Perspective -- Chapter 7: Non-pharmacological Approaches Based on Mind-Body Medicine to Enhancement of Cognitive and Brain Reserve in Humans -- Chapter 8: Roles of Synaptic Plasticity in Functional Recovery After Brain Injury -- Chapter 9: Integrated Methods of Neuromodulation for Guiding Recovery Following Stroke -- Chapter 10: Resilience in Brain Networks After Stroke -- Chapter 11: Epigenetics and brain plasticity: back to function -- Chapter 12: Functional Role of Physical Exercise and Omega-3 Fatty Acids on Depression and Mood Disorders -- Chapter 13: BRAIN RECOVERY IN CHILDHOOD: THE INTERACTION BETWEEN DEVELOPMENTAL PLASTICITY AND REGENERATIVE MECHANISMS -- Chapter 14: Estrogen Neuroprotective Activity After Stroke and Spinal Cord Injury -- Chapter 15: Making Meaning of Acquired Brain Injury: Resources for Functional Recovery -- Chapter 16: An Update on Premorbid Personality Traits and Brain Recovery - Another Aspect of Resilience -- Chapter 17: Psychological Aspects of Recovery After Brain Injury: A Focus on Psychodynamic Factors -- Chapter 18: Artificial Intelligence applications for Traumatic Brain Injury research and clinical management.
    Kurzfassung: The importance of this unique book's approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery following injury. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and psychological resilience the authors present a book that will help lead to the development of better treatment strategies for functional recovery from brain damage. The new edition is fully updated throughout and contains completely new chapters on brain recovery in childhood, epigenetic aspects of brain recovery, and artificial intelligence techniques in traumatic brain injury research.
    Materialart: Online-Ressource
    Seiten: XXIV, 406 p. 1 illus. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031249303
    Serie: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 21
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Biochemical markers. ; Proteins. ; Metabolism. ; Genomics. ; Biomarkers. ; Proteins. ; Metabolism. ; Genomics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. The COVID-19 Pandemic: SARS-CoV-2 Structure, Infection, Transmission, Symptomology and Variants of Concern -- Chapter 2. Long-term Vaccination and Treatment Strategies for COVID-19 Disease and Future Coronavirus Pandemics -- Chapter 3. Consequences of the Lockdown - Domestic Violence during the COVID-19 Pandemic -- Chapter 4. Psychological distress impact of Coronavirus disease (COVID-19) outbreak on three continents: A systematic review and meta-analysis -- Chapter 5. A Molecular Biomarker-based Triage Approach for Targeted Treatment of Post-COVID-19 Syndrome Patients with Persistent Neurological or Neuropsychiatric Symptoms -- Chapter 6. Genetic Associations with Coronavirus Susceptibility and Disease Severity -- Chapter 7. COVID Diagnostics: from Molecules to Omics -- Chapter 8. Assessing Biomarkers in Viral Infection -- Chapter 9. Proteomic Investigation of COVID-19 Severity During the Tsunamis Second Wave in Mumbai -- Chapter 10. NMR-Metabolomics in COVID-19 Research -- Chapter 11. Potential Biomarkers of Mitochondrial Dysfunction Associated with COVID-19 Infection -- Chapter 12. Red Cell Distribution Width as a Prognostic Indicator for Mortality and ICU Admission in Patients with COVID-19 -- Chapter 13. Predicting the COVID-19 Patients Status using Chest CT Scan Findings: A Risk Assessment Model Based on Decision Tree Analysis -- Chapter 14. Inferring Recombination Events in SARS-CoV-2 Variants In Silico -- Chapter 15. Amplicon-based Nanopore Sequencing of Patients Infected by the SARS-CoV-2 Omicron (B.1.1.529) Variant in India -- Chapter 16. Perspectives on Rapid Antigen Tests for Downstream Validation and Development of Theranostics -- Chapter 17. Machine Learning and COVID-19: Lessons from SARS-CoV-2 -- Chapter 18. The Relationship between Psoriasis, COVID-19 Infection and Vaccination during Treatment of Patients -- Chapter 19. Immunogenicity of Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV; Sinopharm) and Short-term Clinical Outcomes in Vaccinated Solid Organ Transplant Recipients: A Prospective Cohort Study -- Chapter 20. Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective -- Chapter 21. Antiviral Mechanisms of Curcumin and its Derivatives in Prevention and Treatment of COVID-19: A review -- Chapter 22. Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial -- Chapter 23. Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach -- Chapter 24. The Potential Effect of Royal Jelly on Biomarkers Related to COVID-19 Infection and Severe Progression -- Chapter 25. Statins: Beneficial Effects in Treatment of COVID-19 -- Chapter 26. Multiplex Immunoassay Approaches Using Luminex® xMAP® Technology for the Study of COVID-19 Disease -- Chapter 27. Rapid Detection of SARS-CoV-2 Variants of Concern by Genomic Surveillance Techniques.
    Kurzfassung: The COVID-19 pandemic caused by the SARS-CoV-2 virus has affected nearly every country and territory in the world. Although worldwide vaccination efforts have reduced the risk of serious disease outcomes, disparities in distribution have led to multiple waves of SARS-CoV-2 outbreaks and the emergence of variants of concern, some of which have enhanced infectivity and ability to evade existing vaccines. Hence there is an increasing interest in understanding the evolution of viruses like SARS-CoV-2, as well as improving our capacity to effectively current and manage future pandemics. This new volume reviews the most effective omic techniques for increasing our understanding of COVID-19, to improve diagnostics, prognostics, and genomic surveillance, and to facilitate development of effective treatments and vaccines. Chapters are written by an international team of experts and explore methods in the areas of genomics, transcriptomics, proteomics, and metabolomics. Techniques used to assess physiological function at the molecular level and artificial intelligence approaches used for more effective validation and translation of biomarker candidates into clinical use are also discussed. This book is an excellent resource for researchers studying biomarkers, virology, metabolic diseases, and infectious diseases, as well as clinical scientists, physicians, drug company scientists, and healthcare workers.
    Materialart: Online-Ressource
    Seiten: XI, 513 p. 87 illus., 74 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031280122
    Serie: Proteomics, Metabolomics, Interactomics and Systems Biology, 1412
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 22
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Zoology. ; Neurochemistry. ; Neuroscience. ; Zoology. ; Neurochemistry.
    Beschreibung / Inhaltsverzeichnis: 1. Introduction to the complexity of cell surface and tissue matrix glycoconjugates. -- 2. Introduction to cells comprising the nervous system. -- 3. Synthesis -- processing -- and function of N-glycans in N-glycoproteins. -- 4. Synthesis of O-linked glycoconjugates in the nervous system. -- 5. Chemistry and function of glycosaminoglycans in the nervous system. -- 6. Use of glycan-targeted antibodies/lectins to study the expression/function of glycosyltransferases in the nervous system. -- 7. Capillary electrophoresis and mass spectrometry-based glycosylation analysis in glycomics and glycoproteomics. -- 8. Structural analysis of oligosaccharides and glycoconjugates using NMR. -- 9. Glycolipid and glycoprotein expression during neural development. -- 10. Gangliosides and cell surface ganglioside glycohydrolases in the nervous system (request them to include gal-cer and sulfatide). -- 11. Role of myelin-associated glycoproteins in the peripheral nervous system. -- 12. Glycosignaling: a general review. -- 13. Glycosphingolipids in the regulation of the nervous system. -- 14. O-GlcNAcylation of neuronal proteins: Roles in neuronal functions and in neurodegeneration. -- 15. Glycoconjugates in nuclear membranes. -- 16. N-glycosylation in regulation of the nervous system. -- 17. Role of carbohydrates in the interaction of pathogens with neural cells. -- 18. Glycoconjugate changes in aging and age-related diseases. -- 19. Gangliosides and glycolipids in neurodegenerative disorders. -- 20. Inborn errors of glycosphingolipid catabolism and potential treatment. -- 21. Neurological aspects of human glycosylation disorders. -- 22. Glycoconjugates and neural tumors. -- 23. Galectins and neuroinflammation . -- 24. Glycoconjugates and neuroimmunological diseases. -- 25. Targeting nanoparticle drug carriers to the brain. -- 26. Use of quantum dots to treat inherited lysosomal storage diseases. -- 27. MALDI-FTICR MS imaging of nervous system glycoconjugates.
    Kurzfassung: This new edition provides comprehensive coverage of the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic fundamental principles as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. New topics include a detailed discussion of cells found within the nervous system, an extensive listing of congenital disorders of glycosylation of both proteins and lipids, the roles of glycans in neuronal axon growth/guidance and voltage-gated channels, the role of intra-lysosomal luminal vesicles in lysosomal storage disorders, and, in the time of the COVID-19 pandemic, the role of carbohydrates in infection by SARS-CoV-2. The breadth and depth of topics covered make this an essential reference for those new to the field as well as for more experienced investigators.
    Materialart: Online-Ressource
    Seiten: XII, 501 p. 96 illus., 73 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031123900
    Serie: Advances in Neurobiology, 29
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 23
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Neurology . ; Neurosciences. ; Nervous system Diseases. ; Biomedical Research. ; Neurology. ; Neuroscience. ; Neurological Disorders.
    Beschreibung / Inhaltsverzeichnis: PART I: Fundamental Aspects -- Chapter 1. Definition of Tremor -- Chapter 2. Membrane Mechanisms of Tremor -- Chapter 3 Advances in the Genetics of Human Tremor -- Chapter 4. Two origins of tremors related to the Guillain-Mollaret triangle: the forward model-related tremor and the inferior olive oscillation-related tremor -- PART II:Tremor in Clinical Practice -- Chapter 5. Physiologic Tremor -- Chapter 6. Rest Tremor -- Chapter 7. Postural Tremors -- Chapter 8. Isometric Tremor -- Chapter 9. Essential Tremor and Other Forms of Kinetic Tremor -- Chapter 10. Cerebellar lesions and tremor -- Chapter 11. Orthostatic Tremor -- Chapter 12. Posttraumatic Tremor and Other Posttraumatic Movement Disorders -- Chapter 13 Tremor in Childhood -- Chapter 14. Metabolic Causes of Tremor -- Chapter 15. Drug-Induced Tremor -- Chapter 16. Tremor: The Clinical Approach to Reach the Diagnosis -- PART III: Assessment of tremor -- Chapter 17. Signal Processing -- Chapter 18. Diffusion imaging in Tremor -- Chapter 19. The role of the noradrenergic system in tremor pathogenesis -- Chapter 20. Metabolic Networks in Parkinson’s Disease -- PART IV: Therapies -- Chapter 21. Deep brain stimulation for tremor -- Chapter 22 Mechatronic Devices for Upper Limb Tremor.
    Kurzfassung: Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society. New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.
    Materialart: Online-Ressource
    Seiten: X, 558 p. 86 illus., 59 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031261282
    Serie: Contemporary Clinical Neuroscience,
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 24
    Online-Ressource
    Online-Ressource
    Cham :Springer Nature Switzerland :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Analytical chemistry. ; Toxicology. ; Biomedical Research. ; Analytical Chemistry. ; Toxicology.
    Beschreibung / Inhaltsverzeichnis: Microplastic research publications from 1991 to 2020 -- Characterization and toxicology of microplastics in soils, water and air -- Coral feeding behavior on microplastics -- Microplastics remediation in the aqueous environment -- Removal of environmental microplastics by advanced oxidation processes -- Techniques for removal and degradation of microplastics -- Occurrence and removal of microplastics in wastewater treatment plants -- Microplastic souces, transport, exposure, analysis and removal -- Airborne microplastics in outdoor and indoor environments -- Nanoplastic sources, characterization, ecological impact, remediation and policies -- Microplastics in soil-plant systems.
    Kurzfassung: Microplastics and nanoplastics have been recently found in most environmental media and in living organisms, thus representing a serious health concern of yet poorly known adverse consequences. This book summarizes recent findings on the sources, behavior, transformation, toxicity and remediation of microplastics, with focus on soils, water, wastewater, air, soils, plants and corals. Advanced methods for sampling, characterization, removal and degradation of microplastics.
    Materialart: Online-Ressource
    Seiten: VIII, 282 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031363511
    Serie: Environmental Chemistry for a Sustainable World, 73
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 25
    Schlagwort(e): Medicine Research. ; Biology Research. ; Forensic sciences. ; Medical jurisprudence. ; Biomedical Research. ; Forensic Science. ; Forensic Medicine.
    Beschreibung / Inhaltsverzeichnis: Module 1_Introduction to Forensic Science & Crime -- Module 2_Criminalistics -- Module 3_ Forensic Biological Sciences -- Module 4_Forensic Physical Sciences -- Module 5_Forensic Chemical Sciences -- Module 6_Emerging fields in Trends in Forensics.
    Kurzfassung: This textbook provides essential and fundamental information to modern forensics investigations. It discusses criminalistics and crime scene aspects, including investigation, management, collecting and packaging various types of physical evidence, forwarding, and chain of custody. It presents fundamental principles, ethics, challenges and criticism of forensic sciences and reviews the crime typologies, the correlates of crime, criminology, penology, and victimology. It provides a viewpoint on legal aspects, including types of evidence, the procedure in the court and scrutiny of the evidence and experts. The book summarizes forensic serological evidences such as blood, semen, saliva, milk-tears, sweat, vaginal fluids, urine, and sweat. It also provides an overview of forensic examination of different types of evidence and also includes comprehensive detailing of forensic ballistics including firearm classification, bullet comparison and matching. Further, it explores the examinations of drugs, chemicals, explosives, and petroleum products. It focuses on the various aspects of forensic toxicology, including the study of various poisons/toxins, associated signs and symptoms, a fatal dose /fatal period of poisons. The book also emphasizes digital and cyber forensics, including classification, data recovery tools, encryption and decryption methods, image, and video forensics. It is a useful resource for graduate and post-graduate students in the field of Forensic Science.
    Materialart: Online-Ressource
    Seiten: XV, 839 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819913770
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 26
    Schlagwort(e): Neurosciences. ; Neurophysiology. ; Developmental neurobiology. ; Neuroscience. ; Neurophysiology. ; Development of the Nervous System.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Introduction: What are dendritic spines? -- Chapter 2: Techniques to render dendritic spines visible in the microscope -- Chapter 3: Electrophysiology of dendritic spines: information processing, dynamic compartmentalization and synaptic plasticity -- Chapter 4: Dendritic spines, synaptogenesis and synaptic pruning for the developmental organization of brain circuits -- Chapter 5: Neurotrophic factors and dendritic spines -- Chapter 6: Glial cell modulation of dendritic spine structure and synaptic function -- Chapter 7: Dendritic spines in learning and memory: from first discoveries to current insights -- Chapter 8: Steroid hormone interaction with dendritic spines: implications for neuropsychiatric disease -- Chapter 9: Morphological features of human dendritic spines.
    Kurzfassung: This reference provides detailed coverage of dendritic spines, the fascinating neuronal components that modulate synaptic transmission, development, strength, and plasticity and are involved in the function of multiple areas of the nervous system. The density, shape, and function of spines may indicate the cellular connectivity and synaptic plasticity in normal and pathological conditions. This field has undergone dramatic advances in terms of techniques and experimental findings from in vitro to in vivo data, from animal models to human neurons, and computational models using artificial intelligence. To address these cutting-edge findings, the book provides state-of-the-art, comprehensive coverage with chapters written by the leading international researchers in the field. The authors consider the multiple implications for the study of dendritic spines with broad implications in the neurosciences and related areas.
    Materialart: Online-Ressource
    Seiten: XV, 499 p. 123 illus., 103 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031361593
    Serie: Advances in Neurobiology, 34
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 27
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Neuropsychology. ; Clinical psychology. ; Psychiatry. ; Neuroscience. ; Neuropsychology. ; Clinical Psychology. ; Psychiatry.
    Beschreibung / Inhaltsverzeichnis: Preface -- PART 1: To fear or not -- Disambiguating fear as an emotional state vs. threat detection. Molecular and Neural circuits of fear extinction. Psychological and theoretical elements on the concept of fear extinction. Neural circuit of fear extinction: psychophysiology -- PART 2: Individual differences in fear extinction -- The impact of sex differences and sex hormones on fear extinction. Impact of sleep on fear extinction. Impact of stress and exercise on fear extinction. Intersect between the intrinsic and extrinsic factors that modulate fear extinction -- PART 3: Psychopathology -- Fear extinction and its relevance to psychopathology. Developmental fear and its extinction imaging. Fear extinction and adult psychopathology -- Part 4: Therapeutics and neuromodulations of fear extinction -- Exposure therapy and other behavioral therapeutics targeting fear extinction circuits. Novel pharmacotherapeutics targeting fear extinction circuits. Reconsolidation and its link and impact on fear extinction. Technological advances in exposure therapy: virtual and augmented reality. Novel approaches using neurostimulation targeting fear extinction.
    Kurzfassung: This book aims to provide the reader a neuroscientific understanding surrounding a very simple question: how do we learn not to fear? Exploring answers to this question is very important for two reasons. First, learning about the neural mechanisms of fear extinction is of relevance to everyone’s life - it is such a basic yet relevant question to our daily experiences. Therefore, understanding brain mechanisms of fear and its regulation is essential from a basic neuroscience point of view. Second, excessive fear and the inability to regulate its expression is one of the hallmarks of fear-, anxiety-, trauma-, and stressor-related psychopathologies. And as such, learning about how fear is acquired, stored, expressed, and regulated could help advance our understanding of the etiology of psychopathology, the maintenance of symptoms pertaining to failure to regulate fear, and could help us develop novel therapeutics to equip providers and patients with the tools to better quell their fears. The contributions contained in this book are provided by experts in the fields of basic and clinical neuroscience, experimental and clinical psychology, and neuropsychiatry. The contributions are organized to start the reader with basic definitions of how we define fear, how we study its neural circuits at the molecular and cellular levels, how to study human behavior and the brain using state-of-the art experimental and statistical tools, to how much fear contributes to psychopathology. This volume ends with current advances aimed to enhance the capacity to extinguish fear; a clinical result that would aid in the treatment of multiple psychiatric disorders, followed by a discussion on future directions of this highly important and relevant field.
    Materialart: Online-Ressource
    Seiten: VIII, 387 p. 100 illus., 30 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031430053
    Serie: Current Topics in Behavioral Neurosciences, 64
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 28
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Animal culture. ; Biotechnology. ; Animal biotechnology. ; Freshwater and Marine Ecology. ; Animal Science. ; Biotechnology. ; Animal Biotechnology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1_ Recent developments in Biosensor Technology for Fisheries and Aquaculture -- Chapter 2_Application of CRISPR-Cas9 Technology in Fish -- Chapter 3_ Nano-technological applications in Aquatic Health Management -- Chapter 4_Phenotypic plasticity and transgenerational immune priming: opportunities and potential in fisheries -- Chapter 5_Heat shock proteins in stress response: a promising tool for fish health management -- Chapter 6_Immunostimulants: Boon for disease management in Aquaculture -- Chapter 7_Molecular markers and their application in fisheries and aquaculture -- Chapter 8_Applications of Electronics in Fisheries and Aquaculture -- Chapter 9_Metatranscriptomics: A tool to study the host-microbe interactions and functional profile of fish intestinal microbiota under changing environmental conditions -- Chapter 10_Bioremediation and its application in aquaculture -- Chapter 11_Application of Probiotics in Aquaculture -- Chapter 12_Identifying novel antibiotic resistance genes (ARGs): Important aspect of metagenomic research.
    Kurzfassung: This edited book is focused on SDG 14: life below water. This book covers all aspects of fish biotechnology and health management. A detailed description is provided of CRISPR Cas9 technology application in the development of superior variety of fish with better growth, disease resistance, etc., accompanied by numerous helpful photographs and schematic diagrams. In addition, recent developments in nanotechnology and its application in fisheries production enhancement have been discussed. Further, topics includes, probiotics, immunostimulants, fish genetic markers, bioremediation, metagenomics, transgenerational immune priming, application of cell culture in fisheries and nano-biosensor application on fish disease diagnosis, pollution monitoring, etc. are provided in details. . The book is helpful for researchers, teachers, students, farmers, and entrepreneurs in utilizing the knowledge on recent advancements in different aspects of fish genetics and biotechnology for future research and aquaculture production enhancement.
    Materialart: Online-Ressource
    Seiten: XVIII, 246 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819929818
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 29
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Ecology . ; Biodiversity. ; Freshwater and Marine Ecology. ; Ecology. ; Biodiversity.
    Beschreibung / Inhaltsverzeichnis: Chapter 1_ An Introduction to the Functions and Ecosystems Services associated with aquatic macrophytes -- Chapter 2_ Factors structuring Aquatic Macrophytes -- Chapter 3_ Aquatic Macrophytes: Ecology, Function and Services in Niger Delta, Nigeria -- Chapter 4_ Environmental and Ecological Importance of Indian Aquatic Macrophytes -- Chapter 5_ Macrophytes used as complementary medicines for curing human ailments to facilitate livelihood opportunities -- Chapter 6_ Macrophytes and their role in wetland ecosystems -- Chapter 7_ Ecotoxicology of REEs in aquatic macrophytes and prospect for bioremediation of REEs -- Chapter 8_ Efficiency of Aquatic Plants for Remediation of Wastewater -- Chapter 9_ Phytoremediation of organic contaminants: An ecofriendly approach based application of aquatic macrophytes -- Chapter 10_ Remediation of heavy metals by different aquatic macrophytes -- Chapter 11_ Translocations of heavy metals in aquatic macrophytes naturally grown in the riverine ecosystem -- Chapter 12_ Enhanced Effluent Treatment and Bioelectricity Generation Using Coupled Constructed Wetland-Microbial Fuel Cell (CW-MFC) Technology: Challenges and Opportunities -- Chapter 13_ Role of microbial communities and aquatic macrophytes in constructed wetlands for tannery wastewater treatment: Challenges and opportunities -- Chapter 14_ Role of plant-bacteria association in constructed wetlands for the removal of iron (Fe) from contaminated water. .
    Kurzfassung: This book is a comprehensive collection of information about the features, functions, and services of aquatic macrophytes. As primary producers, aquatic macrophytes form the basis of food webs, play a major role in highly productive aquatic ecosystems, and have a significant impact on ecosystem functions and services. Macrophytes are also known to strongly influence the micro-climate and biogeochemical processes occurring in the littoral zones of marine ecosystems and the sediment dynamics of freshwater systems. They also serve as highly effective carbon sinks and play an important role in carbon sequestration. This book deals with various aspects of aquatic macrophytes, including nutrient recycling, biogeochemical processes, biomass production, wetland ecosystems, water resource management, carbon sequestration, environmental clean-up, and bioenergy production. Additionally, it presents the current status of aquatic macrophytes and discusses the impact of climate change on these plants. The book also highlights the major challenges associated with harnessing the benefits provided by aquatic macrophytes as ecosystem services. The book holds value and relevance for academicians and scientists working in the related domain. Additionally, it will serve as a valuable resource for students and researchers working in the field of ecology, biogeochemistry, wetland conservation, phytoremediation, elements biomonitoring, wastewater management, bioenergy production, etc.
    Materialart: Online-Ressource
    Seiten: X, 311 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819938223
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 30
    Online-Ressource
    Online-Ressource
    Cham :Springer Nature Switzerland :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Anatomy. ; Information visualization. ; Biophysics. ; Biomedical Research. ; Anatomy. ; Data and Information Visualization. ; Bioanalysis and Bioimaging.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. The Importance of Integrating the Visual Arts into the Medical Curriculum -- Chapter 2. Using Medical Illustration to Improve Understanding of Endometriosis -- Chapter 3. Editorial Medical and Scientific Illustration -- Chapter 4. Current Approaches in Narrative Medical Visualization -- Chapter 5. Animation for Science Communication: A Description of the Production Process and Contexts for Using Science Animation -- Chapter 6. Effect of the Rings: A Visual Story Design Comparing Three Chemical Characters -- Chapter 7. Diabetes Year One, Random Fluctuations and Mental Goblins: Auto-Ethnographic Pathographies and Medical Comics -- Chapter 8. Playing with Science: Games as a Medium of Science Communication -- Chapter 9. Increasing Microbiology Literacy about the Public Health Threat of Antimicrobial Resistance Through Art-Science Interactions -- Chapter 10. Collaged Creatures: Using Collage Art Practice and Posthuman Ethics to Discuss Bioengineering Hybrids.
    Kurzfassung: This edited book explores the breadth of approaches undertaken by scientists, artists and communicators in their crucial role making science accessible, engaging and impactful. Contemporary approaches in science illustration and visualization include a variety of creative methodologies that are valuable for effective communication, teaching, learning and professional practice. These range in method from anatomical drawings used in medical curricula, to 2D animations and editorial illustrations available in the public realm. They also include unexpected approaches such as the use of tabletop board games, comics and collage in understanding our bodies, emergent health threats and cutting-edge science developments. If you are a scientist seeking to enhance your ability to communicate your research or an artist interested in biomedical visualization, this volume serves as an introduction to contemporary approaches in science illustration and communication. By understanding the creative methods and techniques employed in this field, we can collectively work towards fostering a deeper appreciation of art in science, and continue to captivate and inspire audiences worldwide. .
    Materialart: Online-Ressource
    Seiten: XVI, 252 p. 158 illus., 140 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031416521
    Serie: Biomedical Visualization, 4
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 31
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Zoology. ; Ecology . ; Oceanography. ; Conservation biology. ; Freshwater and Marine Ecology. ; Biodiversity. ; Zoology. ; Biooceanography. ; Conservation Biology.
    Beschreibung / Inhaltsverzeichnis: Part I. Introduction -- Chapter 1. Insights from Cuban Coral Reefs -- Part II. History -- Chapter 2. Research History of Corals and Coral Reefs in Cuba -- Part III. Description -- Chapter 3. Physical-Geographic Characteristics of Cuban Reefs -- Chapter 4. Outline of the Geology, Geomorphology and Evolution of the Late Qua-ternary Shelf and Uplifted Marine Terraces of Cuba; Tectonic and Sea Level Control of Present Day Coral Reef Distribution -- Chapter 5. A Remote Sensing Appraisal of the Extent and Geomorphological Diversity of the Coral Reefs of Cuba -- Part IV. Biota -- Chapter 6. Macrophytes Associated with Cuban Coral Reefs -- Chapter 7. Sponges: Conspicuous Inhabitants of the Cuban Coral Reefs and Their Potential as Bioindicators of Contamination -- Chapter 8. Species List of Cuban Stony Corals: Class Anthozoa, Order Scleractinia; Class Hydrozoa, Suborders Capitata and Filifera -- Chapter 9. Octocoral Forests: Distribution, Abundance, and Species Richness in Cuban Coral Reefs -- Chapter 10. Current State of Knowledge of Reef Mollusks in Cuba -- Chapter 11. Herbivory on Cuban Coral Reefs -- Chapter 12. Chronology of the Lionfish Invasion in Cuba and Evaluation of Impacts on Native Reef Fishes -- Chapter 13. Sharks and Rays in Cuban Coral Reefs: Ecology, Fisheries, and Conservation -- Chapter 14. Mesophotic Coral Ecosystems of Cuba -- Part V. Ecology, Conservation and Management -- Chapter 15. Status of Cuban Coral Reefs -- Chapter 16. Population Genetics of Cuba’s Scleractinian Corals -- Chapter 17. Multiple Cumulative Effects on Coral Reefs of the Northwestern Cuban Region -- Chapter 18. Guanahacabibes National Park: Research, Monitoring and Man-Agement for the Conservation of Coral Reefs -- Chapter 19. Ciénaga de Zapata Biosphere Reserve: Integrating Science with the Management of Coral Reefs -- Chapter 20. Coral Reefs in Cuban Marine Protected Areas -- Part VI. Economic Valuation -- Chapter 21. Economic Valuation of the Coral Reefs of Jardines de la Reina and Punta Francés National Parks, Cuba -- Chapter 22. The Economic Value of Coral Reefs in the Context of Marine Protected Areas: Experiences of the South Cuban Archipelago Project -- Chapter 23. Fish Can Be More Valuable Alive Than Dead.
    Kurzfassung: This comprehensive volume gathers foremost experts on the coral reefs of Cuba who represent a spectrum of disciplines, including biology, conservation ecology, economics and geology. The volume is organized along general themes including the Cuban Reef biota, reefs occurring in the Mesophotic and Eutrophic zones, ecology, conservation, management and the economic importance of the coral reefs of Cuba. The combination of case studies, new and previously published research, historical overview and examples of the ways in which research has contributed to the management and conservation of Cuban coastal resources provides a unique reference for graduate students and professionals holding a wide range of interests and expertise related to coral reef systems.
    Materialart: Online-Ressource
    Seiten: XI, 438 p. 176 illus., 147 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031367199
    Serie: Coral Reefs of the World, 18
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 32
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Regenerative medicine. ; Biomaterials. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering. ; Biomaterials.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. An Introduction to Scaffolds, Biomaterial Surfaces, and Stem Cells -- Part I. Structural Scaffolds and Bio-activation -- Chapter 2. Polymeric and Biomimetic ECM Scaffolds for Tissue Engineering Applications -- Chapter 3. Versatile Hydrogels in Regenerative Medicine -- Chapter 4. Multilayer Microcapsules with Tailored Structures and Properties as Delivery Carriers for Drugs and Growth Factors -- Part II Biomaterials Surfaces/Interfaces and Bio-interactions. Chapter 5. Interactions of Biomaterial Surfaces with Proteins and Cells -- Chapter 6. Surface Modification of Tissue Engineering Scaffolds -- Chapter 7. Gradient Biomaterials and Their Impact on Cell Migration -- Chapter 8. Stem Cell Differentiation Mediated by Biomaterials/Surfaces -- Part III Regeneration of Some Clinic-Targeted Tissues -- Chapter 9. Cartilage Regeneration -- Chapter 10. Skin Regeneration -- Chapter 11. Regeneration of Blood Vessels -- Chapter 12. Cardiac repair and regeneration -- Chapter 13. Nerve Regeneration.
    Kurzfassung: This book reviews state of the art of polymeric biomaterials for regenerative medicine and highlights advances in both fundamental science and clinical practice. It summarizes the latest techniques in polymeric scaffold fabrication, delivery carriers, physiochemical property modulation, as well as their influence on the adhesion and performance of biomolecules, cells, and tissues. It also describes methods for creating biofunctional surfaces/interfaces and subsequently modulating the host response to implantable materials. Lastly, it discusses the applications of biomaterials and constructs in soft-tissue regenerative medicine. It is a valuable resource for materials scientists and engineers wishing to identify research priorities to fulfill clinical needs and provides physicians with insights into emerging novel biomaterials. This integrated approach also offers engineering students a sense of the relevance of materials science in the development of novel therapeutic strategies. In the second edition, most of the chapters are updated according to the latest progress of this research field. A new chapter on nerve regeneration is also included.
    Materialart: Online-Ressource
    Seiten: VIII, 577 p. 1 illus. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9789819969487
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 33
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Ecology . ; Oceanography. ; Bioclimatology. ; Environmental management. ; Freshwater and Marine Ecology. ; Biodiversity. ; Biooceanography. ; Climate Change Ecology. ; Environmental Management. ; Ocean Sciences.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. A Global View of the Cold-Water Coral Reefs of the World -- Chapter 2. Biology, Ecology and Threats to Cold-Water Corals on Brazil’s Deep-Sea Margin -- Chapter 3. Cold-Water Corals of the World: Gulf of Mexico -- Chapter 4. Cold-Water Coral Reefs of the Southeastern United States -- Chapter 5. Norwegian Coral Reefs -- Chapter 6. Waters of Ireland and the UK -- Chapter 7. Life and Death of Cold-Water Corals across the Mediterranean Sea -- Chapter 8. Cold-Water Coral Reefs in the Oxygen Minimum Zones off West Africa -- Chapter 9. New Zealand: South West Pacific Region -- Chapter 10. Deep-Sea Corals of the North and Central Pacific Seamounts.
    Kurzfassung: Cold-water corals form reef structures in continental margin and seamount settings world-wide, making them more wide-spread and abundant than shallow-water reefs. Their role in these ecosystems is no less important than the influence that shallow-water coral reefs have on tropical systems. They create habitat structure, host endemic species, enhance elemental cycling, alter current flow, sequester carbon, and provide many other ecosystem services that we are just beginning to understand. The rapidly evolving state of knowledge of cold-water and deep-sea coral reefs has not been compiled in over 10 years. This volume synthesizes recent and historical information, reveals new findings from reefs that have been discovered only recently, and presents key avenues for future research. We are on the cusp of understanding the critical role that cold-water coral reefs play in the world’s oceans, and this book lays the foundation on which this knowledge will be built in the future.
    Materialart: Online-Ressource
    Seiten: XVI, 293 p. 107 illus., 99 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031408977
    Serie: Coral Reefs of the World, 19
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 34
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Zoology. ; Sustainability. ; Population biology. ; Conservation biology. ; Ecology . ; Freshwater and Marine Ecology. ; Biodiversity. ; Zoology. ; Sustainability. ; Population Dynamics. ; Conservation Biology.
    Beschreibung / Inhaltsverzeichnis: Part I. Fish Resources and Fishing Areas of the Western Balkans -- Chapter 1. Fish Resources of Inland Waters and Fisheries in Slovenia, Management, Sustainability and Conservation -- Chapter 2. Inland Fisheries in Croatia: Historical Aspects, Fish Resources, Management and Conservation -- Chapter 3. Fish Resources and Fisheries in Bosnia and Herzegovina – Overview, Sustainability, and Conservation -- Chapter 4. Inland Fisheries in Serbia: Historical Aspect, Fish Resources, Management and Conservation -- Chapter 5. The Freshwater Fish Resources and Freshwater Fisheries of Montenegro, Management, Sustainability and Conservation – With a Special Perspective on Lake Skadar -- Chapter 6. Fish and Fisheries of the Republic of North Macedonia, Current Situation and Its Perspective -- Chapter 7. Fish Resources of Inland Waters and Fisheries in Albania, Management, Sustainability and Conservation -- Part II. Some Fish Species of the Western Balkans Important for Fisheries and Conservation -- Chapter 8. Freshwater Crayfish of Western Balkan: Is It Possible to Use Them Sustainably or Do They Need Prompt Conservation Actions? -- Chapter 9. Salmonid Fish Species – Opportunities for Sustainable Use under Multiple Pressures and Current Climatic Change -- Chapter 10. Past and Future of Sturgeon Species (Acipenseridae) in Western Balkans – Case for Permanent Conservation or Sustainable Management -- Part III. Effects of Stressors on Inland Water Ecosystems and Fish Resources -- Chapter 11. Eutrophication of Fishing Waters and the Influence of Cyanobacterial Occurrence and Blooming on Fish Resources – Case Studies in Serbia -- Chapter 12. Pollution of Fishing Waters of the Western Balkan – Potentially Toxic Elements and Their Impact on the Ecological Sustainability of Fish Resources -- Chapter 13. Invasive Macroinvertebrate and Fish Species and Their Impact on Fish Resources: A Case Study on Fishing Waters of Serbia -- Part IV. Fish Stock Assessment Methods -- Chapter 14. A Brief Overview of the Development of the ES-HIPPO Model for Assessing the Sustainability and Conservation Priorities of Fish, Fish Resources, and Inland Water Habitats -- Part V. Conservation and Aquaculture -- Chapter 15. Тhe Role and Importance of Aquaculture for the Ecological Sustainability of Fish Resources in the Inland Water of Serbia -- Chapter 16. Huchen Hucho hucho (Linnaeus, 1758) in Croatia: Distribution, Genetic Diversity, Threats and Conservation -- Chapter 17. Future Perspective of Sustainable Development of Freshwater Fisheries and Conservation of Threatened Fish Species, Crustaceans and Molluscs -- Part VI. Social Aspect -- Chapter 18. Political and Socio-Economic aspects of Fisheries in Inland and Coastal Waters of the Western Balkan -- Chapter 19. Fish Resources of the Western Balkans, Sustainable Use and/or Conservation?.
    Kurzfassung: This book provides a detailed evaluation of the hydro-ecological characteristics of the Western Balkans, an area characterized by still preserved inland waters and fish resources important for the European continent, as well as the biodiversity of inland waters important for the planet Earth. Freshwater ecosystems cover only 1% of the Earth's surface; however, they are a habitat for about 40% of fish species. At the same time, inland fisheries make less than 12% of the world's global fish catch, with 43% coming from low-income and food-deficient countries (Africa, South America, Southeast Asia). In Europe, the Western Balkans have significant fishing waters and fish resources, including the Middle Danube drainage (Sava, Drina, Velika Morava river systems), large ancient lakes (Skadar/Shkodra, Ohrid, Prespa, Dojran), and the Adriatic basin characterized by endemic and commercially important species. However, in contrast to the high fishing potential in a significant part of the Western Balkans, diverse and specific political, economic, and social factors largely had a negative impact on the state of fish resources. This volume is multidisciplinary and provides a sound knowledge base for scientific and practical fisheries. In addition, it may be a valuable guide for managers and conservationists worldwide to adapt methods and procedures for the ecological sustainability of fish resources under specific local, natural, and socio-economic conditions. Finally, the content is a good reference for natural sciences and agriculture students studying fish, fish resources, and fisheries sciences. It would improve their knowledge and perspectives on the challenges of sustainable use and conservation of inland water resources.
    Materialart: Online-Ressource
    Seiten: XXII, 707 p. 261 illus., 233 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031369261
    Serie: Fish & Fisheries Series, 43
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 35
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Neurosciences. ; Public health. ; Medicine Research. ; Biology Research. ; Neuroscience. ; Public Health. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: 1. The effect of sleep disruption and circadian misalignment on the immune system -- 2. Changes in the sleep and circadian pattern of sleep during the COVID-19 pandemic -- 3. Anxiety and depression during the COVID-19 pandemic and their impact on sleep -- 4. Sleep problems during the COVID-19 pandemic in children and adolescents -- 5.Sleep problems during the COVID-19 pandemic in children and adolescents -- 6. Sleep disturbances among healthcare workers during the COVID-19 pandemic -- 7. Sleep disturbances among patients with COVID-19 infection -- 8. Sleep patterns and sleep disturbances during the lockdown periods -- 9. Impact of COVID-19 Mobility Restrictions on Sleep and Wellbeing -- 10. COVID-19 vaccines and sleep disturbances -- 11. Sleep during the COVID-19 pandemic: structural inequity and racial disparity -- 12. The effect of cognitive-behavioral therapy and coping strategies on sleep disturbances during the COVID-19 pandemic -- 13. Sleep and circadian rhythm in post-COVID-19 patients -- 14. COVID-19 and obstructive sleep apnea -- 15. The correlation between COVID-19 infection and restless legs syndrome -- 16. Impact of COVID-19 pandemic lockdown on disorders of hypersomnolence -- 17. Sleep, Physical Activity, and Diet Patterns During COVID-19 Pandemic -- 18. Impact of screen time during the pandemic of COVID-19 on sleep habits -- 19. Dreams and nightmares during the COVID-19 pandemic -- 20. The impact of the COVID-19 pandemic on sleep medicine services -- 21. Protocols for conducting sleep studies during pandemics -- 22. Management of hospital and home positive airway pressure machines during pandemics -- 23. Telemedicine and telemonitoring of sleep disorders during the COVID-19 pandemic -- 24.Changes in Positive Airway Pressure Application and Practices in Patients with Sleep-Related Breathing Disorder during the COVID-19 Pandemic -- 25. Potential Therapeutic Effects of Melatonin on SARS-CoV-2 Infection.
    Kurzfassung: This book examines the correlation of the coronavirus disease-19 [CE1] [AAS2] (COVID-19) infection with sleep, circadian rhythm, and sleep disorders. The chapters of the book explore sleep problems during the COVID-19 pandemic and its association with psychological distress and also review the prevalence of clinical cases of insomnia, anxiety, and depression in COVID-19 patients. The book further presents the correlation between sleep, circadian rhythms, and immunity that contributes toward more severe COVID-19. It summarizes the evidence on the interplay between circadian biology, sleep, and COVID-19. The chapters of the book discuss the relationship between obstructive sleep apnea (OSA) and adverse COVID-19 outcomes. Towards the end, the book presents studies on the anti-inflammatory, antioxidant, and immunotropic properties of melatonin and provides mechanistic insights into the potential therapeutic use of melatonin during the SARS-CoV-2 infection. The last chapter describes the publication output of sleep-related research during the pandemic and provides an overview and trends on sleep and covid-19 publication output. This book is an excellent source for neurologists, sleep specialists, and public health specialists.
    Materialart: Online-Ressource
    Seiten: XXVI, 430 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819902408
    Serie: Progress in Sleep Research,
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 36
    Schlagwort(e): Medicine Research. ; Biology Research. ; Vocational guidance. ; Career education. ; School management and organization. ; School administration. ; Biomedical Research. ; Career Counseling. ; Career Skills. ; Organization and Leadership.
    Beschreibung / Inhaltsverzeichnis: Part 1: Setting the scene -- Chapter 1: Life after Academia: Launching your Pharma/Biotech Career -- Chapter 2: Competences for Pharmacists -- Chapter 3: Job and Career Opportunities in the Pharmaceutical Industry: An Overview -- Part 2: Opportunities along the drug/product life cycle -- Chapter 4: Career Opportunities in Toxicology -- Chapter 5: Job Possibilities in Clinical Research -- Chapter 6: How to Get and Develop a Career in a Market Access Role in the Medical Devices Industry -- Chapter 7: Job Opportunities in Pharmaceutical Marketing -- Chapter 8: Working in Medical Affairs and Clinical Operations: Life-Changing Careers -- Chapter 9: The Role of Medical Science Liaison -- Chapter 10: Career Development for Physicians in the Biopharmaceutical Industry -- Part 3: Opportunities in Supportive Functions -- Chapter 11: Job and Career Opportunities in Regulatory Affairs/Science -- Chapter 12: Job Opportunities in Clinical Research Quality Assurance -- Chapter 13: Job Opportunities in Quality Assurance Related to Manufacturing of Medicinal Products -- Part 4: Other Opportunities in the Pharmaceutical and Biomedical Sector -- Chapter 14: Careers Perspective in a Science and Technology Park -- Chapter 15: To be or not to be: Entrepreneurship and Enterprise Creation as a Way to Innovate in Life Sciences -- Chapter 16: How to Become a Successful Hospital and Community Pharmacist -- Part 5: Practical tips and tricks -- Chapter 17: A Successful Career in the Life Sciences Industry: How to Write your Strongest Resumé and Ace that Interview -- Chapter 18: Skill Building for Career Advancement: Public Speaking and Networking -- Chapter 19: Training Opportunities for a Career in the Pharmaceutical and Biomedical Industry/Sector.
    Kurzfassung: Written by dedicated and active professionals from different areas of the pharmaceutical, biomedical, and medtech sectors, this book provides information on job and career opportunities in various life sciences industries. It also contains useful tips to launch your own startup. The pharmaceutical, biomedical and medical technology sectors offer a wide range of employment opportunities to talented and motivated young graduates. However, many of these employment prospects are not well known to early career scientists, who concentrate primarily on the scientific and academic content of their fields of interest. The book is divided into five parts: Part 1 provides an academic perspective that focuses on the specific preparation required in the final years of study to embark on a successful career in the pharmaceutical and biomedical industries. In Part 2, industry experts discuss employment possibilities all along the drug or product life cycle, from discovery research and development to commercialisation. Part 3 follows, highlighting opportunities in support functions such as regulatory affairs or quality assurance. Part 4 focuses on additional opportunities in the wider biomedical sector, while Part 5 contains practical tips and training opportunities for entering the pharmaceutical and biomedical industries. In the epilogue, the authors reflect on this fascinating field and its career prospects. The book offers a multidisciplinary perspective on career opportunities in the pharmaceutical and biomedical industry to a wide range of students and young life scientists. .
    Materialart: Online-Ressource
    Seiten: XXI, 328 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031149115
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 37
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Clinical medicine Research. ; Epidemiology. ; Diseases Causes and theories of causation. ; Biomedical Research. ; Clinical Research. ; Epidemiology. ; Pathogenesis.
    Beschreibung / Inhaltsverzeichnis: 1. Introduction on Tuberculosis: Integrated Studies for a Complex Disease -- 2. Global Tuberculosis Epidemiology -- 3. Heterogeneity in Tuberculosis -- 4. The Unequivocal Relationship between Tuberculosis and Tobacco: Integration of Two Maladies -- 5. Relationship between Pre-existing Cancer and Tuberculosis -- 6. Laboratory Diagnosis of Tuberculosis -- 7. The Role of Diagnostic Microdevices in the Fight Against Tuberculosis -- 8. Immunodiagnostics of Tuberculosis: Recent Discoveries -- 9. Role of Bronchoscopy in Diagnostics and Treatment of Tuberculosis -- 10. Diagnosis of Childhood Tuberculosis in Low- and Middle-income Countries -- 11. Pediatric Tuberculosis: Current Evidence for Laboratory Diagnosis -- 12. A Multidisciplinary Approach Towards Finding and Treating All Tuberculosis Patients -- 13. Chemotherapy for Drug-Susceptible Tuberculosis -- 14. The Pharmacokinetic and Pharmacodynamic Properties of Antitubercular Medications -- 15. Immune Approaches In Tuberculosis Treatment -- 16. Inhalation Therapy in Pulmonary Tuberculosis -- 17. Role of Micronutrients in Tuberculosis Management -- 18. Drug Resistance in Tuberculosis: Mechanisms, Diagnosis, New Responses, and the Need for An Integrated Approach -- 19. Resistance in Tuberculosis: Molecular Mechanisms and Modulation -- 20. Personalized Tuberculosis Care for Drug-Resistant Tuberculosis -- 21. Important Targets and Inhibitors of Mycobacterium Tuberculosis -- 22. P-type ATPases: A Relevant Component in Mycobacterium tuberculosis Viability -- 23. The Challenges of Antitubercular Drug Discovery -- 24. Exploring Decaprenylphosphoryl-β-D-ribose 2’-Epimerase 1 (DprE1): A Target for Anti-Tubercular Drugs -- 25. Energy Pathways in Mycobacterium Tuberculosis -- 26. Drug Discovery for Non-Tuberculous Mycobacteria: Recent Updates -- 27. Challenges for Contact Tracing and Tuberculosis Preventive Therapy Scale-up -- 28. Exploring Problematizations Underlying Tuberculosis Control Strategies: A Cross-Country Analysis of India and Kenya -- 29. Challenges in Prevention and Management of Tuberculosis -- 30. Tuberculosis in Contacts and Healthcare Workers -- 31. Tuberculosis Among People Who Use Drugs: Multilevel Considerations for Prevention, Diagnosis, and Treatment -- 32. Anti-Tumor Necrosis Factor-α Antagonists and Tuberculosis -- 33. Breast Tuberculosis -- 34. Central Nervous System Tuberculosis: Pathogenesis, Diagnosis, and Management -- 35. Pleural Tuberculosis -- 36. Ocular Tuberculosis -- 37. Ocular Tuberculosis: Biomarkers for Risk Stratification -- 38. Bone and Joint Tuberculosis -- 39. Abdominal Tuberculosis: Pathogenesis, Clinical Features, and Diagnosis -- 40. Bovine Tuberculosis at The Interface of Cattle, Wildlife, and Humans -- 41. Evolution and Molecular Characteristics of Mycobacterium Tuberculosis and Mycobacterium Bovis -- 42. Animal Tuberculosis: Gross Lesions and Anatomopathological Diagnosis -- 43. Estimation of Microbial Mutation Rates in Tuberculosis Research -- 44. The Role of Epigenetics in the Development of Anti-Tuberculosis Drug Resistance -- 45. Multiomics Integration of Tuberculosis Pathogenesis -- 46. Lung Microbiome in Tuberculosis -- 47. The Correlation of Microbiota and Host Epigenome in Tuberculosis -- 48. The Pathogenesis and Progression of Sarcoidosis from The Standpoint of Tuberculosis -- 49. Tuberculosis: A Historical and Global Bioethical Perspective -- 50. The Problem of Tuberculosis: Myths, Stigma, and Mimics -- 51. Tuberculosis: Integrated Studies for a Complex Disease 2050.
    Kurzfassung: Tuberculosis have been documented since antiquity and the search of the microbes that cause this disease started more than three hundred years ago. Nevertheless, tuberculosis remains an important global health issue, with millions of people affected per year in addition to millions that remain undiagnosed and untreated. Patients with tuberculosis face the full range of recurrence, reinfection, and resistance due to diagnostic, prophylactic, and therapeutic procedures that are not as effective as they should be. In addition, variability in susceptibility to tuberculosis pose a complex problem with numerous interrelated variables. This volume is devoted to the understanding of Tuberculosis focusing on its heterogeneity, its transmission, manifestations, related conditions, diagnosis, treatments, drug resistance and prevention.
    Materialart: Online-Ressource
    Seiten: XXIV, 1116 p. 363 illus., 239 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031159558
    Serie: Integrated Science, 11
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 38
    Schlagwort(e): Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Beschreibung / Inhaltsverzeichnis: Sensory Regeneration in the Inner Ear: History, Strategies and Prospects -- Non-mammalian Hair Cell Regeneration: Cellular Mechanisms of Morphological and Functional Recovery -- Cell Junctions and the Mechanics of Hair Cell Regeneration -- Mammalian Hair Cell Regeneration -- Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors -- Inner Ear Cells from Stem Cells – a Path Towards Inner Ear Cell Regeneration -- Spiral ganglion neuron regeneration in the cochlea: regeneration of synapses, axons and cells -- Genetic and Epigenetic Strategies for Promoting Hair Cell Regeneration in the Mature Mammalian Inner Ear.
    Kurzfassung: This volume provides a detailed update on progress in the field of hair cell regeneration with emphasis on more "prospective" views of the various facets of regeneration research. Sensory Regeneration in the Inner Ear: History, Strategies and Prospects Mark E. Warchol, and Jennifer S. Stone Non-mammalian Hair Cell Regeneration: Cellular Mechanisms of Morphological and Functional Recovery Madeleine Hewitt, David W. Raible, and Jennifer S. Stone Cell Junctions and the Mechanics of Hair Cell Regeneration Mark A. Rudolf, and Jeffrey T. Corwin Mammalian Hair Cell Regeneration Ruth Taylor, and Andrew Forge Specification and Plasticity of Mammalian Cochlear Hair Cell Progenitors Melissa M. McGovern, and Andrew K. Groves Inner Ear Cells from Stem Cells – a Path Towards Inner Ear Cell Regeneration Amanda Janesick, Eri Hashino, and Stefan Heller Spiral ganglion neuron regeneration in the cochlea: regeneration of synapses, axons and cells Steven H. Green, Sepand Bafti, Benjamin M. Gansemer, A. Eliot Shearer, Muhammad Taifur Rahman, Mark E. Warchol, and Marlan R. Hansen Genetic and Epigenetic Strategies for Promoting Hair Cell Regeneration in the Mature Mammalian Inner Ear Brandon C. Cox, John V. Brigande, and Bradley J. WaltersDr. Mark Warchol is Professor of Otolaryngology at Washington University School of Medicine in St. Louis. Dr. Jennifer Stone is Research Professor of Otolgaryngolldy/Head and Neck Surgery, University of Washington School of Medicine, Seattle. Dr. Allison Coffin is an Associate Professor in the Department of Integrative Physiology and Neuroscience at Washington State University Vancouver. Dr. Arthur N. Popper is Professor Emeritus and research professor in the Department of Biology at the University of Maryland, College Park. Dr. Richard R. Fay (Deceased) was Distinguished Research Professor of Psychology at Loyola University Chicago.
    Materialart: Online-Ressource
    Seiten: XVI, 229 p. 44 illus., 35 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031206610
    Serie: Springer Handbook of Auditory Research, 75
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 39
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Public health. ; Epidemiology. ; Medical policy. ; Medicine, Preventive. ; Health promotion. ; Biomedical Research. ; Public Health. ; Epidemiology. ; Health Policy. ; Health Promotion and Disease Prevention.
    Beschreibung / Inhaltsverzeichnis: Introduction on Integrated Science of Global Epidemics -- Emerging Viral Infections in Human Population -- One Health as An Integrated Approach: Perspectives from Public Services for Mitigation of Future Epidemics -- Multipronged Approach to Combat COVID-19: Lessons from Previous Pandemics for the Future -- Response to Disease Outbreaks in Africa: A Call to Build Resilient Health Systems -- Navigating Global Public Influenza Surveillance Systems for Reliable Forecasting -- Three Respiratory Syndrome Epidemics (SARS, MERS, COVID-19) in Two Decades: Clinical Epidemiological Considerations -- Epidemic in Complex Networks and Some Ideas About the Impact of Isolation Strategies in the Context of the COVID-19 Pandemic -- Optimal Control: Application and Applicability in Times of Pandemics -- Analysis of A COVID-19 Model Implementing SocialDistancing as An Optimal Control Strategy -- Impact of Policy Implementations on the Propagation of COVID-19 Before Vaccine -- Environmental Factors Associated with Global Pandemic Transmission and Morbidity -- Urbanization and the Epidemiology of Infectious Diseases: Towards the Social Framing of Global Responses -- Pandemics and Mass Casualties: Cornerstones of Management -- Social Marketing Contributions to Mitigate Global Epidemics -- The Significance of Super Intelligence of Artificial Intelligence Agencies in the Social Savageries of COVID-19: An Appraisal -- Integration of Sex and Gender Approaches in National Ethics Committees’ Mandate to Appraise COVID-19 Research Protocols: Lessons from West Africa -- Psychology, Law, Ethics, Telehealth, and the Global Pandemic -- Physical Inactivity, Sedentarism, and Low Fitness: A Worldwide Pandemic for Public Health -- The Global Epidemic of Diabesity: Are We Heading for An Unsustainable Future? -- Nutrition, Function, and Quality of Life in Older Adults Socially Isolated Due to the COVID-19 Pandemic: A Focus on Telehealth Interventions -- Africa’s Response to Pandemics -- Vaccine Hesitancy and Refusal: History, Causes, Mitigation Strategies -- Vaccine Compliance versus Trust in a Pandemic -- Child Development in A Crisis: A Pandemic -- HIV/AIDS Problems and Policies in Adolescent Population -- Addressing Needs of Foreign Schoolchildren to Combat a Global Epidemic of Dengue Virus Infection: Transnational and Trans-sectoral Initiatives -- Integrated Science of Global Epidemics 2050.
    Kurzfassung: The “Integrated Science of Global Epidemics” is the new proposed volume of Integrated Science Book series, aiming to publish the results of the most updated ideas and reviews on Global Epidemics. The whole world is suffering from complex problems, border less problems and global solution should be developed. The Integrated Science of Global Epidemics aims to highlight the combination of different disciplines, including formal sciences, physical-chemical sciences and engineering, biological sciences, medical sciences, and social sciences, to deal with complex problems such as global epidemics. This contributed volume could be used as guidelines for the entire scientific community and policy makers to successfully face these global threats. Chapter 27 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Materialart: Online-Ressource
    Seiten: XII, 623 p. 170 illus., 144 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031177781
    Serie: Integrated Science, 14
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 40
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Zoology. ; Life sciences. ; Behavior genetics. ; Neuroscience. ; Zoology. ; Life Sciences. ; Behavioral Genetics.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to neurogenetics -- Chapter 2. Neurogenetic analysis in Caenorhabditis elegans -- Chapter 3. Regionalisation of the early nervous system -- Chapter 4. Early neurogenesis and gliogenesis in Drosophila -- Chapter 5. Neural stem cells and brain tumour models in Drosophila -- Chapter 6. Eye development in Drosophila: from photoreceptor specification to terminal differentiation -- Chapter 7. Neurogenetics of memory, learning and forgetting -- Chapter 8. Evolution and origins of nervous systems -- Chapter 9. Neural stem and progenitor cells in the mammalian brain -- Chapter 10. Models of neurodegenerative diseases.
    Kurzfassung: This textbook provides students with knowledge of neurogenetics, neurogenesis, neuronal specification and function, neuronal networks, learning and memory formation, brain evolution, and neurodegenerative diseases. Students are introduced to topics of classical developmental genetics as well as modern molecular and neurogenetic methods. Using a wealth of examples from current research, the textbook takes a strong applied approach. Using animal models such as Drosophila melanogaster and Caenorhabditis elegans as well as mammalian systems, the interrelationships between genes, neurons, nervous systems, and behaviour under normal and pathological conditions are illustrated. The textbook aims encourage students to address biological questions in neurogenetics and to think about the design of their own experiments. It targets primarily master and graduate students in neurobiology, but is also a valuable teaching tool for instructors in these fields.
    Materialart: Online-Ressource
    Seiten: VII, 212 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031077937
    Serie: Learning Materials in Biosciences,
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 41
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Animal biotechnology. ; Ecology . ; Oceanography. ; Food science. ; Freshwater and Marine Ecology. ; Animal Biotechnology. ; Biooceanography. ; Food Engineering.
    Beschreibung / Inhaltsverzeichnis: Diversity, Distribution, and Biology of Sea Cucumber -- Nutritional Components of Sea Cucumber and the Biochemical Characteristics of Autolytic Enzymes -- The Functional Components of Sea Cucumber and their Nutritional and Biological Activities -- Traditional Processing Technologies and Products of Sea Cucumber: Historical Review -- The Pretreatment Technology of Raw Sea Cucumber and New Processing Technology of Salted Sea Cucumber -- The New Processing Technology of Dried Sea Cucumber Products -- Ready-to-Eat Sea Cucumber Products and Collagen Stabilization Technology -- The Extraction, Separation Technology and New Product Development of Sulfated Polysaccharides from Sea Cucumber -- The Extraction, Separation Technology and New Product Development of Functional Lipids from Sea Cucumber -- The Extraction, Separation Technology and New Product Development of Collagen Peptides from Sea Cucumber -- The Quality Management Systems and Standards of Sea Cucumber Products -- Food Safety Issues and Regulatory Requirements of Sea Cucumber Products and Their Internationalization.
    Kurzfassung: Sea cucumbers belong to the Phylum Echinodermata. There are more than 900 recorded species of sea cucumber of which more than 40 are edible. As a food source, sea cucumbers are rich in protein, low in fat, rich in collagen, sulfated polysaccharides, phospholipids, glycolipids, saponins and other functional components. Therefore, sea cucumbers have important nutritional and medicinal value. Growing awareness of these health benefits has promoted growth in marine aquaculture and processing technologies for the development of sea cucumber products for many applications.Novel perspectives of nutritional functions and processing technologies of sea cucumbers are defined in this book. The chemical structure and nutritional function of sea cucumbers are systematically reviewed. These include the functional/nutritional components, the endogenous enzymatic properties related to processing efficiency and product quality, and the efficient preparation technology of functional components. The traditional processing technology is presented as the background context to highlight the advances in new processing technologies including low-temperature cooking technology based on controllable negative pressure system, heat pump-hot-blast air combined drying technology, microwave sterilization of instant sea cucumber, collagen stabilization technology. The book finishes with the authentication of sea cucumber types and origin, quality standards, product quality control systems and food safety requirements.
    Materialart: Online-Ressource
    Seiten: VI, 364 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031165122
    Serie: Advances in Marine Bioprocesses and Bioproducts,
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 42
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Research Methodology. ; Clinical medicine Research. ; Biomedical Research. ; Research Skills. ; Clinical Research.
    Beschreibung / Inhaltsverzeichnis: Section I: Understanding Grant Writing: What is your Aim (Ambition-Interest-Mission), and what you want to do -- What is a grant? How to prepare for writing a grant proposal application -- Funders Perspective: What the funding body expects from researchers? -- Funding organizations for science and healthcare -- Obtaining letters of support -- Section II: The process for grant writing: Writing a Grant Proposal for a Single Centre Study: step-by-step approach -- Budgeting the project-detailing the required funding and expenditure -- Proving the competency of the researcher and the adequacy of the infrastructure to carry out the research -- Agreement and MOU – ethical and legal aspects of funding for healthcare research -- Write an impressive cover page (Covering letter) and abstract for the grant proposal application -- Surveillance plan and site visit – Roles and rights of the researcher and the funding agency -- Sources of funding and acknowledgment – Good Clinical Practice Guidelines -- Writing a grant proposal for a Collaborative study -- Checklist for grant proposal – Mandatory elements -- Tips for improvising the chance of getting the grant -- Dealing with The Rejected Grant Proposal- Learning From The Mistakes -- Section III: Grant writing for specific regional funding organizations: Preparing a grant proposal for medical research in the UK -- Preparing a grant proposal for the USA -- Preparing a Grant Proposal for Australia -- Proposal Writing for Grant Application in Malaysia -- Grant writing for other Asian countries.
    Kurzfassung: Conducting research requires resources to meet the research need. The resources in the research institutes/ centers are often inadequate, limiting the research outcome. Research grants help overcome those limitations and help the researchers carry out quality research without any restriction. Grant proposal writing is an essential skill to be mastered by every researcher. However, the majority of the medical schools, except the few research institutes, do not have a structured learning module for obtaining grants. On most occasions, the skill of writing grant proposals goes by self-learning. For students, it is burdening due to the tremendous time consumed to learn the craft of writing the grant proposal and the exhausting clinical and academic work. This book is carefully prepared to keep in mind the difficulties faced by the young researchers and the students concerning choosing a funding agency, grant makers' expectations, budgeting, surveillance and site visits, rights of the researcher and the funding agency, and ethical and legal aspects of obtaining the grant. The book also covers the alternate plan for partial funding or interruption of the financing, reporting the source of funding and acknowledgment, good clinical practice guidelines, and dealing with the rejected grant proposal. The research projects are often dropped or modified extensively due to the limited resources in the existing facility. The researchers are forced to compromise the research objective due to expensive requirements. There is a shortage of awareness regarding the availability of funding and grant for the conduct of research. Even if the researchers are aware of obtaining the financing, there is a lack of training in grant proposal writing, which is essential in getting the research funding. This book on grant proposal writing for medical and healthcare professionals covers such difficulties and deficiencies. It will provide complete companionship from knowing the funding agency to obtaining the grant. .
    Materialart: Online-Ressource
    Seiten: XX, 247 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789811970184
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 43
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Endocrine glands. ; Immunology. ; Neuroscience. ; Endocrine System. ; Immunology.
    Beschreibung / Inhaltsverzeichnis: Part I. Concepts -- Chapter 1. A History of Immune and Neuroendocrine System Interactions -- Chapter 2. Philosophical Perspectives on Neuroendocrine-Immune Interactions: The Building Block Model and Complementary Neuro-Endocrine-Immune-Microbiota Systems Approaches -- Chapter 3. The Behavioural Immune System of Lower Vertebrates -- Part II. Regulatory Pathways -- Chapter 4. Cytokines and Hypothalamo-Pituitary-Adrenal Axis Activation: Now a Classic of Immune-Neuroendocrine System Interactions -- Chapter 5. Catecholamines and Immunomodulation -- Chapter 6. Neuroendocrine-immune Interactions in Major Depressive Disorder: Glucocorticoids and Glucocorticoid Receptors -- Chapter 7. Brain Fluids, Blood-Brain Interfaces, and Their Involvement in Neuroimmune Regulation During Development and in Adulthood -- Chapter 8. Neuropeptide Binding Autoantibodies Regulating Neuroendocrine Communications -- Part III. Modulation -- Chapter 9. Postnatal Development of Neuroimmune Responses -- Chapter 10. Sex Differences in Neuroendocrine-Immune Interactions -- Chapter 11. Biological Clocks and Immune Function -- Chapter 12. Influence of the Gut Microbiota on Neuroendocrine-Immune Interactions -- Part IV. Disease -- Chapter 13. Energy Balance and Neuroendocrine-Immune Regulation in Chronic Inflammatory and Neoplastic Diseases: An Evolutionary Perspective -- Chapter 14. Autonomic, Immune, Metabolic and Neuroendocrine Dimensions of Anorexia Nervosa: An Integrative View.
    Kurzfassung: The concepts of the neuroendocrine system and the immune system emerged more or less simultaneously in the second half of the 20th century. Although these systems have a high degree of autonomy, it has also become clear that they interact in many ways and at different levels. This book focuses on the neuroendocrine and immune interactions that are fundamental to normal development and maintenance of health. The first introductory chapters are devoted to the historical and philosophical concepts within the field, as well as evolutionary considerations, offering critical interdisciplinary perspectives on the development of this field of research. Without attempting an exhaustive overview, the book then introduces some of the regulatory pathways that mediate interactions between the neuroendocrine and immune systems and examines modulating factors such as age and sex. In addition, several chapters address the importance of neuroendocrine-immune interactions in some disease states. Readers can expect to gain a broad perspective of neuroendocrine-immune interactions in development, health, and disease, along with a critical evaluation of current methods used in the field. Given its scope, the book is essential reading for undergraduate and graduate students with an interest in neuroendocrinology, neuroimmunology, and neuroscience, as well as postdoctoral fellows and established researchers seeking a comprehensive overview and historical perspective of the field of neuroendocrine-immune interactions.
    Materialart: Online-Ressource
    Seiten: XIII, 386 p. 29 illus., 26 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031213588
    Serie: Masterclass in Neuroendocrinology, 13
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 44
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Zoology. ; Biodiversity. ; Freshwater and Marine Ecology. ; Ecosystems. ; Zoology. ; Biodiversity.
    Beschreibung / Inhaltsverzeichnis: Habitat: Sunlit Rocky Grounds -- Habitat: Shady Rocky Grounds -- Habitat: Dark Caves -- Habitat: Intertidal Zone -- Habitat: Sandy Grounds -- Habitat: Seagrass -- Habitat: Muddy Grounds -- Habitat: Open Waters -- Humans and the Sea.
    Kurzfassung: This book invites snorkelers and divers on an educational visit to the most important ecosystems of the Mediterranean Sea. Keystone species from brown algae to dolphins are presented in their marine habitats and understood as part of a complex ecological system. Instead of grouping animals and plants taxonomically, we have organised them according to the eight main habitats of the Mediterranean Sea. Our journey starts with different types of rocky grounds, then takes you further to the Mediterranean’s sandy and muddy grounds, and finally ends with the fish and dolphins of the blue open sea. You will be introduced to 220 ecologically significant animal and plant species via the texts of Daniel Abed-Navandi, a long-time lecturer on the biodiversity of the Mediterranean Sea at the University of Vienna, and the photographs of Georg Glaeser, the master behind the camera, who captures marine life on the spot.
    Materialart: Online-Ressource
    Seiten: VIII, 200 p. 406 illus., 404 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031223341
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 45
    Schlagwort(e): Neurosciences. ; Neuroanatomy. ; Neurophysiology. ; Developmental neurobiology. ; Cognitive neuroscience. ; Neuroscience. ; Neuroanatomy. ; Neurophysiology. ; Development of the Nervous System. ; Cognitive Neuroscience.
    Kurzfassung: This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.
    Materialart: Online-Ressource
    Seiten: XIV, 742 p. 182 illus., 127 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031150708
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 46
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Psychiatry. ; Neurology . ; Neuroscience. ; Psychiatry. ; Neurology.
    Beschreibung / Inhaltsverzeichnis: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.
    Kurzfassung: The Dictionary of Hallucinations, second edition, is an alphabetical listing of issues pertaining to hallucinations and other misperceptions. They can be roughly divided into four categories: 1. Definitions of individual hallucinatory symptoms 2. Medical conditions and substances associated with the mediation of hallucinations 3. Historical figures who are known to have experienced hallucinations 4. Miscellaneous issues Each of the definitions of individual hallucinatory symptoms includes: a definition of the term its etymological origin the year of introduction (if known) a reference to the author or authors who introduced the term (if known) a description of the current use a brief explanation of the etiology and pathophysiology of the symptom at hand (if known) references to related terms references to the literature The second edition of A Dictionary of Hallucinations serves as a reference manual for neuroscientists, psychiatrists, psychiatric residents, psychologists, neurologists, historians of psychiatry, general practitioners, and academics dealing professionally with concepts of hallucinations and other sensory deceptions. This new edition provides updated information and references, and includes newly discovered hallucinations, bringing together contributions by other authorities within the field, with all the entries edited by Prof. Blom.
    Materialart: Online-Ressource
    Seiten: XXVI, 790 p. 604 illus., 364 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031252488
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 47
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Computer simulation. ; Computer science Mathematics. ; Freshwater and Marine Ecology. ; Computer Modelling. ; Mathematical Applications in Computer Science.
    Beschreibung / Inhaltsverzeichnis: Chapter 1 Introduction -- Chapter 2 Processing method of the original data -- Chapter 3 Grey correlation analysis -- Chapter 4 Grey Clustering Analysis -- Chapter 5 Grey System Modeling -- Chapter 6 Grey Prediction -- Chapter 7 Grey decision-making -- Chapter 8 Grey Linear Programming -- Chapter 9 Grey Dynamic Control.
    Kurzfassung: This book reviews the gray system and combines its latest research results in fishery science. The chapters cover the basic concept and theory of gray system, original data processing and gray sequence generation, gray correlation analysis, gray cluster analysis, gray system modeling, gray prediction, gray decision-making, and gray linear programming. The theory of gray system is a new cross-sectional discipline founded in 1982 by Professor Deng Julong, a well-known scholar in China. In recent decades, it has not only been deepened and expanded in theory but also widely used in the fields of society, economy, ocean, agriculture, fishery, and other fields, and made a series of significant scientific achievements. These have laid the foundation for the important position of the gray system theory. Due to the great uncertainty of the fishery resources and the fishery environment involved in the fishery science system, which is completely different from the natural resources on the land, the data and information belong to the category of “poor information”, and the variability and uncertainty are greater than other natural resources. As an extremely effective analytical method and tool, gray system theory has been applied increasingly in fishery science. The book is developed based on well-read and practical literature and will help scientists and research units engaged in scientific research and teaching in fishery science and related fields to develop new research methods and tools. .
    Materialart: Online-Ressource
    Seiten: VII, 196 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819906352
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 48
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Neurosciences. ; Pharmacology. ; Neuroscience. ; Pharmacology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1 Overview of the relationship between aluminum exposure and health of human being.-Chapter 2 The Chemistry of Human Exposure to Aluminum -- Chapter 3 Entry and Deposit of Aluminum in Brain -- Chapter 4 Aluminum as a CNS and immune system toxin across the life span.-Chapter 5 Occupational exposure to aluminum and cognitive impairment -- Chapter 6 Debated relationship between Exposure to Aluminum in Daily Life and Alzheimer’s Disease -- Chapter 7 Animal Model of Aluminum-Induced Alzheimer’s like Disease -- Chapter 8 Aluminum-induced AD-like Pathological Features.-Chapter 9 Aluminum induced neural cells death -- Chapter 10 Aluminum-Induced Electrophysiological Variation, Synaptic Plasticity Impairment, and Related Mechanism.-Chapter 11 Cross Talk Between Aluminum and Genetic Susceptibility -- Chapter 12 Epigenetic modification in aluminum-induced neuron death and synaptic impairment -- Chapter 13 Neurotoxic effects of aluminum and aluminum alloy nanoparticles(TBD) -- Chapter 14 Alumina nanoparticles induced neurotoxic and neurodevelopmental toxic effects.
    Kurzfassung: This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles and amyloid beta—the pathological features of AD, and the possible mechanism of aluminum inducing these pathological features. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed, and more recently the relationship between aluminum-induced epigenetic modification on DNA and non-coding RNAs and neuron death and synaptic impairment. The second edition updates eight chapters according to the most recent researches. Content about aluminum-induced AD-like pathological features, neurotoxic effects of aluminum and aluminum alloy nanoparticles(TBD) and alumina nanoparticles induced neurotoxic and neurodevelopmental toxic effects is also added. In closing, this book provides readers with a systematic summary of aluminum neurotoxicity.
    Materialart: Online-Ressource
    Seiten: XVIII, 313 p. 1 illus. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9789819915927
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 49
    Schlagwort(e): Medicine Research. ; Biology Research. ; Neurology . ; Internal medicine. ; Immunology. ; Biomedical Research. ; Biomedical Research. ; Neurology. ; Internal Medicine. ; Immunology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Malignant Glioma -- Chapter 2. Benign Glioma -- Chapter3. Meningioma and Other Meningeal Tumors -- Chapter4. Epondymomas in Pediatric and Adults -- Chapter5. Medulloblastomas in Pediatric and Adults -- Chapter6. Benign and Malignant Tumors of The Pineal Region -- Chapter7. The Tumors of Choroid Plexus and Other Ventricular Tumors -- Chapter8. Embryonal Tumors of The Central Nervous System with Multilayered Rosettes and Atypical Teratoid/Rhabdoid Tumors -- Chapter9. Glioneuronal and Neuronal Tumors of the Central Nervous System -- Chapter10. Benign and Malignant Tumors of the Pituitary Gland -- Chapter11. Craniopharyngioma in Pediatric and Adults -- Chapter12. Schwannomas of Brain and Spinal Cord -- Chapter13. Other Nerve-Sheet Tumors of Brain and Spinal Cord -- Chapter14. Hemangioblastomas and Other Vascular Originating Tumors of Brain or Spinal Cord -- Chapter15. Brain and Spinal Cord Tumors of Embryonic Origin -- Chapter16. Brain and Spinal Tumors Originating from the Germ Line Cells -- Chapter17. Benign Brain and Spinal Tumors Originating from Bone or Cartilage -- Chapter18. Benign Spinal Tumors -- Chapter19. Other Less Prevalent Tumors of the Central Nervous System -- Chapter20. Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes -- Chapter21. Psychological and Psychiatric Aspects of Brain and Spinal Cord Tumors -- Chapter22. A Brief Explanation on Surgical Approaches for Treatment of Different Brain Tumors.
    Kurzfassung: This book aims to gather the current knowledge regarding different aspects of brain and spinal cord tumors in order to more efficiently help the patients. Brain tumors comprise about 5–9% of all human neoplasms; and the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. The more we know about the nature and characteristic of brain and spinal cord tumors, the more precise decision could be made for each patient, in order to reach the best outcome. While surgical resection, chemotherapy, and radiotherapy have been considered as the standards of care for benign and/or malignant CNS tumors since a long time ago, new therapeutic approaches such as immunotherapy have been recently proposed to be considered for treatment of CNS tumors, especially as in some cases, the tumors might be inoperable or the patient may not benefit from other treatment modalities after several recurrences. The second volume of the book focuses on clinical aspects of these tumors. Accordingly, the most important brain and spinal cord tumors are specifically discussed in each chapter based on a rational outlining for all chapter in this volume: Background and epidemiology, genetics, immunology and molecular biology, histopathology and morphology, imaging and radiologic features, clinical manifestations, therapeutic approaches, surgical intervention, chemotherapy and radiotherapy, new therapeutic modalities, follow-up, and prognosis. The chapters of this volume discuss the following pathologies of brain and spinal cord tumors: malignant glioma, benign glioma, meningiomas and other meningeal tumors, ependymomas, medulloblastomas, pineal tumors, choroid plexus and ventricular tumors, neuroectodermal tumors of CNS, neuroepithelial tumors of CNS, pituitary gland tumors, craniopharyngioma, schwannomas and nerve-sheet tumors, hemangioblastomas and other vascular originating tumors, brain and spinal tumors of embryonic origin, germ line cell tumors, malignant bone or cartilage-originating tumors of brain and spine, benign bone or cartilage-originating tumors of brain and spine, brain tumors affecting the orbit globe and orbit tumors affecting the brain, CNS lymphomas, metastatic lesions of the brain and spine, malignant spinal tumors, benign spinal tumors, brain and/or spinal cord tumors accompanied with other diseases or syndromes, psychological and psychiatric aspects of brain and spinal cord tumors, a brief explanation on surgical approaches for treatment of different brain tumors. This volume of book is useful for physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists, and neuroradiologists.
    Materialart: Online-Ressource
    Seiten: XXIX, 739 p. 287 illus., 159 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031237058
    Serie: Advances in Experimental Medicine and Biology, 1405
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 50
    Schlagwort(e): Medicine Research. ; Biology Research. ; Drug delivery systems. ; Genetics Research. ; Imaging systems in biology. ; Biology Technique. ; Biomedical Research. ; Drug Delivery. ; Genetics Research. ; Biological Imaging. ; Biological Techniques.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Editorial: Biosystems -- 2. Potential of Biotechnology in cancer management -- 3. Biosimilars: Promising and Rapidly Emerging Biotherapeutics -- 4. Applications of Nanomaterials in Medicine: Current status and future scope -- 5. Biomedical Applications of Nanofluids in Drug Delivery.
    Kurzfassung: The book gives an insight into the theoretical background, conceptual understanding, latest developments, and applications in the field of pharmaceuticals in general and drug design, discovery, biosystems, and biomedical and drug delivery technologies in particular . Knowledge is drawn from various disciplines such as Chemistry, Biology, Material Science and Engineering, Statistics, Biomedicine, and Genetics . A host of applications like bio-imaging, novel biological agents, testing, characterization and validation of drugs, computer-based models in drug design, and application of statistical tools in data analysis, design, and development of drug delivery systems, and ecosystems are dealt with in detail. The said book undoubtedly confirms the requirements of the postgraduate students, research scholars, academicians, scientists, and researchers from the academia, pharmaceutical, biotechnology, and chemical engineering domain. The book covers a conceptual understanding of the exploration of drugs in tandem with intended uses, sound ecosystem development, and carriers for drug and supplement delivery.
    Materialart: Online-Ressource
    Seiten: XX, 289 p. 58 illus., 48 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819952816
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 51
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical sciences. ; Drug development. ; Pharmacology. ; Genetics Research. ; Clinical medicine Research. ; Biochemical markers. ; Translational Research. ; Preclinical Research. ; Pharmacology. ; Genetics Research. ; Clinical Research. ; Biomarkers.
    Beschreibung / Inhaltsverzeichnis: MATRICS – an update -- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious mental illness (CNTRaCS) Consortium: Progress and Future Directions -- Attention in Schizophrenia -- Perceptual Functioning -- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers -- Working Memory in People with Schizophrenia -- "Targeting Frontal Gamma Activity with Neurofeedback to Improve Working Memory in Schizophrenia" -- Cognitive Dysfunction as a Risk Factor for Psychosis -- Environmental Risk Factors and Cognitive Outcomes in Psychosis: Pre-, Perinatal, and Early Life Adversity -- Developmental manipulation-induced changes in cognitive functioning -- Genetic underpinnings of cognitive dysfunction in schizophrenia -- Primate models of cognitive deficit re schizophrenia -- Olfactory cognitive deficits -- Medication/Anticholinergic burden impacting cognition in schizophrenia An Update on Treatment of Cognitive Impairment Associated with Schizophrenia -- Cannabis & cognition -- Sex/gender differences -- Neuroinflammation linked to cognition.
    Kurzfassung: This book highlights recent research investigating psychological and neural mechanisms contributing to dysfunctional cognition in people with schizophrenia. The work on cognition in schizophrenia from the past 20 years is highlighted, and emphasis throughout the book is placed on utilizing the Research Domain Criterion framework. Thus, the book also covers animals work relevant to schizophrenia that assesses behaviors utilizing the same framework, enabling mechanistic studies and highlighting potential biomarkers of function. The book also includes important areas of research in the field of cognitive function in schizophrenia that have received less attention, such as cognitive side-effects of current treatments and olfactory-based cognition. Altogether, the book provides a translational perspective of the most-up-to-date research on cognition in schizophrenia to-date, but with identification of novel directions for research initiatives.
    Materialart: Online-Ressource
    Seiten: XII, 497 p. 70 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031264412
    Serie: Current Topics in Behavioral Neurosciences, 63
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 52
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Neurology . ; Neurophysiology. ; Neuropharmacology. ; Neuroscience. ; Neurology. ; Neurophysiology. ; Neuropharmacology.
    Beschreibung / Inhaltsverzeichnis: Molecular Biomarkers.Somatic instability/Telomeres,- Genetic modifiers -- Current clinical trial biomarkers.-Pharmacodynamic biomarkers for Htt-lowering therapeutics.-Inflammatory biomarkers.-Sleep dysregulation markers.-Mitochondrial/Oxidative stress biomarkers.-Microbiomics -- Metabolomics.-Proteomics.-Transcriptomics.-Lipidomics.-Imaging marker overview.-Retinal imaging biomarkers -- MRI - non-invasive functional MRI measures -- The evolution of clinical trial methodology.-Digital biomarkers -- The future of telehealth -- Summary and future trends.
    Kurzfassung: Huntington’s disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.
    Materialart: Online-Ressource
    Seiten: XVI, 475 p. 42 illus., 39 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031328152
    Serie: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 53
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Regenerative medicine. ; Stem cells. ; Neuroscience. ; Regenerative Medicine and Tissue Engineering. ; Stem Cell Biology.
    Beschreibung / Inhaltsverzeichnis: Part 1 General considerations -- Human iPS for clinical applications and cellular products -- 3D-printed iPS disease models -- Part 2 CNS iPSC and organoids -- iPS-derived neurons and brain organoids from patients (brain) -- iPS-derived RGCs (eye) -- iPS-derived glia (brain) -- iPSC to model blood-brain barrier endothelial cells -- Part 3 iPSC-derived nociceptive neurons -- IPSC-based peripheral nerve modeling -- Part 4 Non-neuronal specialized cell types -- iPSC-based drug screening of differentiated cardiomyocyte subtypes -- iPSC-based cardiac disease modeling: from cell to tissue -- iPSC-derived corneal endothelial cell -- iPSC-derived trabecular meshwork (eye) -- iPSC for in vitro disease modeling of diabetes.
    Kurzfassung: Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
    Materialart: Online-Ressource
    Seiten: VIII, 332 p. 100 illus., 30 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031423499
    Serie: Handbook of Experimental Pharmacology, 281
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 54
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Genomics. ; Cancer. ; Immunology. ; Nutrition   . ; Physiology. ; Biomedical Research. ; Genomics. ; Cancers. ; Immunology. ; Nutrition. ; Physiology.
    Beschreibung / Inhaltsverzeichnis: 1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: Nuclear receptors -- 6. DNA methylation -- 7. Histone modifications -- 8. Chromatin remodeling and organization -- 9. Regulatory impact of non-coding RNA -- 10. Genome-wide principles of gene regulation -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and disease -- 14. Cells and tissues of the immune system -- 15. Innate immunity and inflammation -- 16. Adaptive immunity and antigen receptor diversity -- 17. B cell immunity: BCRs, antibodies and their effector functions -- 18. Antigen-presenting cells and MHCs -- 19. T cell immunity: TCRs and their effector functions -- 20. Immunity to bacterial pathogens and the microbiome -- 21. Immunity to viral pathogens and the virome -- 22. Tolerance and transplantation immunology -- 23. Immunological hypersensitivities: Allergy and autoimmunity -- 24. Introduction to cancer -- 25. Oncogenes, signal transduction and the hallmarks of cancer -- 26 Tumor suppressor genes and cell fate control -- 27. Multistep tumorigenesis and genome instability -- 28. Cancer genomics -- 29. Cancer epigenomics.-30. Aging and cancer -- 31. Tumor microenvironment -- 32 Metastasis and cachexia -- 33. Cancer immunology -- 34 Architecture of cancer therapies -- 35 Nutrition and common diseases -- 36 Interference of the human genome with nutrients -- 37. Nutritional epigenetics, signaling and aging -- 38. Chronic inflammation and metabolic stress -- 39. Obesity -- 40. Insulin resistance and diabetes -- 41. Heart disease and the metabolic syndrome -- 42 Epigenetics, inflammation and disease.
    Kurzfassung: The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all processes in physiology, both in health as well as in most common disorders, such as cancer, diabetes as well as in autoimmune diseases. Most non-communicable human diseases have a genetic (= inherited) as well as an epigenetic component. The later one is based on our lifestyle choices and environmental exposures. Many common diseases, such as type 2 diabetes, can be explained only to some 20% via a genetic predisposition. We cannot change the genes that we are born with but we can take care of the remaining 80% being primarily based on our epigenome. Therefore, there is a high level of individual responsibility for staying healthy. Thus, not only biologists and biochemists should be aware of this topic, but all students of biomedical disciplines will benefit from being introduced into the concepts of molecular medicine. This will provide them with a good basis for their specialized disciplines of modern life science research. The book is subdivided into 42 chapters that are linked to a series of lecture courses in “Molecular Medicine and Genetics”, “Molecular Immunology”, “Cancer Biology” and “Nutrigenomics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. This book represents an updated version and fusion of the books textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8). “Molecular Immunology: How Science Works” (ISBN 978-3-030-XXX), “Cancer Biology: How Science Works” (ISBN 978-3-030-75699-4) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4). By combining basic understanding of cellular mechanism with clinical examples, the authors hope to make this textbook a personal experience. A glossary in the appendix will explain the major specialist’s terms.
    Materialart: Online-Ressource
    Seiten: XXXIV, 700 p. 301 illus., 300 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031271335
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 55
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Geographic information systems. ; Sustainability. ; Environmental monitoring. ; Geography. ; Geographical Information System. ; Sustainability. ; Environmental Monitoring. ; Regional Geography.
    Beschreibung / Inhaltsverzeichnis: Introduction -- Remote Sensing Data Preprocessing Technology -- Remote Sensing Extraction Technology of Urban Vegetation Information -- Measurement Technology of Two-Dimensional Urban Green Space -- Measurement Technology of Three-Dimensional Urban Green Space -- Construction Technology of Multi-Scale Perception Model of Urban Green Space -- Evaluation Technology of Remote Sensing in Urban Green Space.
    Kurzfassung: This book presents a systematic study of urban green space remote sensing from multi-dimensional and multi-scale technologies. On the basis of introducing the connotation, science and application value of urban green space, this book focuses on the two-dimensional and three-dimensional information extraction technology of urban vegetation, two-dimensional and three-dimensional measurement technology of urban green space and multi-scale perception technology and discusses the remote sensing evaluation method of urban green space. By exploring the technical advantages of ‘satellite remote sensing + aerial remote sensing + near-ground remote sensing’, urban green space remote sensing promotes the development of urban vegetation research from two-dimensional to three-dimensional observation, so that the quantity, quality and human perception of urban vegetation can be measured. In each chapter, an individual technology/method is introduced, and several cases are cited to demonstrate its practical application. This book offers a valuable reference guide for practitioners in urban planning, landscape greening, environmental protection and urban management, as well as teachers and graduate students engaged in urban remote sensing research.
    Materialart: Online-Ressource
    Seiten: XVI, 240 p. 164 illus., 133 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819907038
    DDC: 910.285
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 56
    Schlagwort(e): Geographic information systems. ; Human geography. ; Environmental management. ; Geographical Information System. ; Human Geography. ; Environmental Management.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Interdisciplinarity, GIScience, and Socio-environmental Research in Latin America -- Chapter 2. Using Spatial Time-series and Field Data to Understand Cultural Drivers of Land Change: Connecting Land Conflict and Land Change in Eastern Amazonia -- Chapter 3. Crossing Boundaries: Transboundary Geographic Information in the Amazon Borderlands of Peru and Brazil -- Chapter 4. Territorial Implications of Economic Diversification in the Waorani Ancestral Lands -- Chapter 5. New Insights on Water Quality and Land Use Dynamics in the Napo Region of Western Amazonia -- Chapter 6. From Mapping to Guiding: An Emergent Framework for the Multiple Uses of Remote Sensing and GIScience in Socio-Environmental Research in the Peruvian Andes -- Chapter 7. The Use of Remote Sensing in Air Pollution Control and Public Health -- Chapter 8. Human-environmental Interactions and their Impacts on Temperate Forests in the Exploradores Valley in Western Patagonia -- Chapter 9. El Chaltén, Argentine Patagonia: A successful Combination of Conservation and Tourism? -- Chapter 10. GIS Approaches to Environmental Justice in Mexico’s Oil and Gas Production Zones with Implications for Latin America -- Chapter 11. Contributions to Socio-Environmental Research through Participatory GIS in Archaeology -- Chapter 12. Comparing Volunteered Data Acquisition Methods on Informal Settlements in Mexico City and São Paulo: a Citizen Participation Ladder for VGI -- Chapter 13. CHALLENGES AND OPPORTUNITIES Interdisciplinary GIScience Research on Human-environment Dynamics in Latin America.
    Kurzfassung: This contributed volume presents relevant examples of socio-environmental research that highlight the challenges and opportunities of using geotechnologies in interdisciplinary settings across the vast, culturally, and environmentally mega-diverse region known as Latin America. While remote sensing has been mostly used for mapping and monitoring physical features, geographic information systems open up opportunities for the integration of socio-economic and environmental data collected through individual and community-based surveys, in-situ measurements, and other participatory research techniques to offer additional analytically grounded power when evaluating socio-environmental processes that shape Latin American landscapes. The topics addressed in this book include deforestation and land degradation, borderlands dynamics, agriculture and agroecological systems, environmental conservation and development, public health, tourism, environmental justice, archeology, volunteered geography and urban planning, among others. The book is intended for academics, graduate and undergraduate classrooms, and general audiences with interest in Latin America and the socio-environmental issues that threaten the sustainability of the region and local communities. The book will also appeal to practitioners, managers, and policy makers interested in the application of geo-technologies and field-based research to address complex socio-environmental problems in the Global South. .
    Materialart: Online-Ressource
    Seiten: XIX, 294 p. 78 illus., 73 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031226809
    Serie: The Latin American Studies Book Series,
    DDC: 910.285
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 57
    Schlagwort(e): Geographic information systems. ; Environmental geography. ; Physical geography. ; Environmental management. ; Geographical Information System. ; Integrated Geography. ; Earth System Sciences. ; Environmental Management.
    Beschreibung / Inhaltsverzeichnis: Development of Reconfigurable Low-Power Measuring IoT Device for Detecting Common Radioactive Elements for Earth and Space Applications -- RECO-FSCA: Reconfigurable Low-Power Implementation of Fprime-Software for CubeSats Applications -- Autonomous Payload Imaging System for Remote Sensing Applications -- Plasma Space Debris Removal System – NIRCSAT-X -- Heat Energy Storage Module for Thermal Management of Small Satellites In Low Earth Orbit Thermal Conditions.
    Kurzfassung: This book covers various aspects of remote sensing and geographic information systems, from the perspective of earth and environmental sciences. The theme of applications of remote sensing and geographic information systems for the purposes of sustainable development highlights the innovative usage of space imaged spectral data in soil characterization. This book merges the selected contributions to the First International Conference of Remote Sensing and Space Sciences Applications (Egypt 2022) aiming to promote the latest findings on the development of Space Technologies and Applications.
    Materialart: Online-Ressource
    Seiten: XIV, 441 p. 168 illus., 157 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031404474
    Serie: Springer Proceedings in Earth and Environmental Sciences,
    DDC: 910.285
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 58
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Geographic information systems. ; Environmental health. ; Public health. ; Sustainability. ; Geographical Information System. ; Environmental Health. ; Public Health. ; Sustainability.
    Beschreibung / Inhaltsverzeichnis: Topic 1. Environmental Quality Monitoring -- Chap1: Applications of Remote Sensing for Air Pollution Monitoring in Thailand: An Early Warning for Public Health -- Chap2: A novel evaluation of air pollution impact from stationary emission sources to ambient air quality via time-series Granger causality -- Chap3: Groundwater Recharge, Monitoring and Finding Suitable Areas for Groundwater Recharge in Northeast Thailand -- Topic 2. Environmental Changes and Health -- Chap4: Health benefits of air pollution reduction during the COVID-19 lockdown period in Thailand using a machine learning algorithm -- Chap5: Satellite-Derived Vegetation Indices as A Criterion for Assessing Green Exposure that is Related to Human Health Burdens -- Chap6: Five common myths about land use change and infectious disease -- Topic 3. Data and Methodological Issues for Health Studies -- Chap7: Geospatial Environmental Data for Planetary Health Applications -- Chap8: Delineating zones of disease diffusion from the amenity-sharing network in Peninsular Malaysia -- Chap9: Approaches for spatial and temporal-spatial clustering analysis in avian influenza outbreaks -- Chap10: Detecting urban form using remote sensing: spatiotemporal research gaps for sustainable environment and human health.
    Kurzfassung: Planetary health involves complex spatial–temporal interactions among agents, hosts, and earth environment. Due to rapid technical development of geomatics, including geographic information systems (GIS) and remote sensing (RS) in the era of big data analytics, therefore, earth data analytics has become one of the important approaches for monitoring earth surface process and measuring of the effects of environment changes on all humans and other living organisms on earth. Various methods in earth data analytics, including spatial–temporal statistics, spatial evolutionary algorithms, remote sensing image analysis, wireless geo-sensors, and location-based analytics, are an emerging discipline in understanding complex interactions in planetary health. This edited book provides a broad focus on methodological theories of earth data analytics and their applications to measuring the process of planetary health, with the goal to build scientific understanding on how geospatial analytics can provide valuable insights in measuring environmental risks in Southeast Asian regions. It is collection of selected papers covering both theoretical and empirical studies focusing on topics relevant to spatial perspectives on planetary health and environmental exposure studies. The book is written for senior undergraduates, graduate students, lecturers, and researchers in applications of geospatial technologies for public health and environmental studies.
    Materialart: Online-Ressource
    Seiten: IX, 217 p. 60 illus., 47 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789811987656
    Serie: Atmosphere, Earth, Ocean & Space,
    DDC: 910.285
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 59
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Geographic information systems. ; Natural disasters. ; Environmental sciences Social aspects. ; Atmospheric science. ; Geographical Information System. ; Natural Hazards. ; Environmental Social Sciences. ; Atmospheric Science.
    Beschreibung / Inhaltsverzeichnis: Overview Of Geospatial Science And Technology -- Geospatial Appraisal Of Vegetation Health And Air Quality Of Delhi During Pre And Post Lockdown Phase Through Multi-Criteria Decision Model -- Pandemic Effect Of Covid-19: Identification, Present Scenario And Preventive Measures -- Impact Of Lockdown (Covid-19) On Air Pollution In India -- Impact Of Covid-19 Pandemic On Environmental Awareness: A Case Study Of Hyderabad City -- Examination Of Radiation Distribution And Its Relation With Stress Degree Day Index In Some Crops Of Yamne River Catchment In Arunachal Pradesh During Pre And Post Covid Times -- Covid 19 And Its Impact On Urban Health Care System -- Impact Of Covid-19 Pandemic On Education Sector Of Kashmir Valley Its Challenges And Future Prospects -- A Study On Socio-Economic Impact Of Covid 19 Pandemic On Tour Operators Of Vishakhapatnam City, Andhra Pradesh -- A Study On Problems Faced By The Street Vendors In Hyderabad City Post Covid-19 Pandemic.
    Kurzfassung: This book identifies, evaluates and reports the impacts of the COVID-19 pandemic on the physical, biological and socioeconomic environment, using the science and technology of geoinformatics. It encourages the environmental considerations in the future city and policy planning and decision-making. For example, according to the World Health Organization, 80% of people living in cities are exposed to polluted air that exceeds healthy levels. City planners have applied the developing concepts of sustainability to modern debates over how cities and regions should be reviewed, regenerated and reformed since the introduction of the concept in developmental science. During the COVID-19 pandemic, a remarkable drop in air pollution has been observed in India and other countries, which has accelerated the shift to green and sustainable development. Geoinformatics can provide solutions and resources for local, sustainable activities in education, health, sustainable agriculture, resource management and related fields. This book serves researchers in a variety of areas, including hazards, land surveys, remote sensing, cartography, geophysics, geology, natural resources, environment and geography.
    Materialart: Online-Ressource
    Seiten: X, 155 p. 68 illus., 67 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819919345
    Serie: Advances in Geographical and Environmental Sciences,
    DDC: 910.285
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 60
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical genetics. ; Biomedical Research. ; Biomedical Research. ; Biomedical Research. ; Medical Genetics.
    Beschreibung / Inhaltsverzeichnis: Chaptre 1. Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction -- Chaptre 2. Epidemiology of Brain and Spinal Cord Tumors -- Chaptre 3. The Role of Neuro-inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 4. The Role of Cellular Immunity and Adaptive Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 5. Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors -- Chaptre 6. Cell of Origin of Brain and Spinal Cord Tumors -- Chaptre 7. The Role of Bioinformatics and Imaging Models in Tumorigenesis and Treatment Response of Brain and Spinal Cord Neoplasms -- Chaptre 8. The Role of Epigenetics in Brain and Spinal Cord Tumors -- Chaptre 9. Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors -- Chaptre 10. Nutrition and Diet: A Double-Edged Sword in Development and Treatment of Brain Tumors -- Chaptre 11. The Role of Nanotechnology in Brain Tumors -- Chaptre 12. The Role of Nanotechnology in Spinal Cord Tumors -- Chaptre 13. The Economic Burden of Malignant Brain Tumors.
    Kurzfassung: Brain tumors comprise about 5–9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well. Besides to the morphologic and histopathologic characteristics, and as each pathologic states first starts with molecular alterations, each tumor may have its own story in the matter of activating tumorigenesis pathways and having specific molecular characteristics. Importantly, the molecular classification of tumors has been highly considered in the past few decades for taking the most appropriate therapeutic approach. On the other hand, the tumors shall have tumor-scape mechanisms preventing the immunologic system to eliminate its invasion. The failure of innate and acquired immune system to defeat tumorigenesis mechanisms would consequently result in tumor development. Interestingly, the neuro-immunologic mechanism plays a role in development of psychiatric manifestations of brain tumors as well. Taking all these to account, the different arms of innate immunity, acquired immunity, and genetics have been approached to defeat development and/or progression of such tumors. Accordingly, the activation immunotherapeutic approaches focus on activating or strengthening the anti-tumor immunologic pathways in order to assist the weakened immune system to defeat the tumor (such as Dendritic cell vaccination, DNA vaccines, peptide vaccines, viral vector-based vaccines, monoclonal antibodies, and CAR T-cell therapy). In addition to immunologic components of brain and spinal cord tumors, numerous genes and genetic pathways have been recognized to take part in tumorigenesis. Taking these non-immune genetic pathways to account, some other therapeutic approaches such as stem cell therapy and gene therapy have been developed in the new era of cancer treatment. Moreover, and besides the biologic and medical aspects of these tumors, different physical/mathematical models have been proposed to either explain or predict tumor behavior. Such models would be advantageous in developing new therapeutic modalities in pre-clinical stages and enter new eras in cancer treatment. The first book of Human Brain and Spinal Cord Tumors, Neuro-immunology and Neuro-genetics, will mainly discuss the neuro-immunology and neurogenetic pathways associated with development of brain and spinal cord tumor. After a short introduction chapter, this book will focus on the role of innate and acquired immunity on development of these tumors and then the immunotherapeutic approaches to defeat these tumorigenesis mechanisms. This book will then focus on genetic aspects of brain and spinal cord tumors and bioinformatics models to describe the behavioral patterns of these tumors, as well as associated therapeutic approaches such as stem cell therapy and gene therapy. This volume of book could be useful for experts in basic sciences, mainly geneticists and immunologists, and also physicians of different specialties, mainly neurosurgeons, neurologists, neuropathologists and neuroradiologists.
    Materialart: Online-Ressource
    Seiten: XX, 231 p. 30 illus., 16 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031147326
    Serie: Advances in Experimental Medicine and Biology, 1394
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 61
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Neurosciences. ; Biology. ; Molecular biology. ; Psychiatry. ; Biomedical Research. ; Neuroscience. ; Biological Sciences. ; Molecular Biology. ; Psychiatry.
    Beschreibung / Inhaltsverzeichnis: 1. Understanding schizophrenia: introductory aspect of the mental disorder from various perspectives -- 2. Genetic mutations and Alternative splicing in schizophrenia -- 3. Understanding the Chemical Interactions in the Brain of Schizophrenia Patients -- 4. A diagnostic perspective of schizophrenia: from past to present -- 5. Is it schizophrenia or not? - Different Biological characterization -- 6. A neurobiological aspect of schizophrenia and the relationship between neurological disorders: depression, anxiety, epilepsy -- 7. Clinical treatment available for schizophrenia -- 8. Insights into the neuro-pharmacological treatment of schizophrenia: past, present, and future -- 9. Managing Schizophrenia – A Challenge for Physicians -- 10. Pharmacotherapy and Emerging Treatment Strategies for Schizophrenia -- 11. Alternative Therapies used in Schizophrenia -- 12. Different phases of schizophrenia patients: from the psychological perspective -- 13. Stigmatizing Attitudes Towards Patients with Schizophrenia Among Medical Professionals and General Population -- 14. Rehabilitation of Schizophrenia-Practical Interventions -- 15. Consumption of Cannabis: A risk factor or a therapeutic agent for patients with Schizophrenia -- 16. Medical Imaging and Schizophrenia: A Study on State-of-art Applications -- 17. Schizophrenia and its Effect on Marital Satisfaction -- 18. The mortality rate in schizophrenia.
    Kurzfassung: This book provides the reader with a thorough understanding of schizophrenia as a complex brain disorder by explaining the various aspects investigated for its cognizance from epigenetics to chemistry and physics to computational approaches. The book covers the key notions of schizophrenia from a variety of facets such as neurogenetics, neurochemistry, neuropharmacology, neurobiology, psychotherapy, psychiatric treatment, cognitive studies, behavioral and societal studies, and computational neurosciences. Individual chapters are focused on crucial topics such as cognitive-behavioral therapy, brain functioning, computational neuroscience, neuro-imaging, and many more. This book explains each section and chapter with utmost clarity to maintain comprehensiveness for every kind of reader. This book covers various classical as well as recent topics from basic to advance level knowledge regarding schizophrenia. The book's contributions regarding its inclusivity of topics, comprehensiveness of language, diversity in knowledge, and focus on the subject will attract all kinds of readers. It can be considered a single comprehensive handy reference book for beginners, including medical students, neuroscientists, researchers, clinicians, and medical practitioners. Cognizance of Schizophrenia will be an invaluable asset for all who are involved in neuroscience research or clinical studies.
    Materialart: Online-Ressource
    Seiten: XII, 312 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789811970221
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 62
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Biotic communities. ; Environmental management. ; Environmental education. ; Freshwater and Marine Ecology. ; Ecosystems. ; Environmental Management. ; Environmental and Sustainability Education.
    Beschreibung / Inhaltsverzeichnis: Part I: Introduction And Context -- Chapter 1: Introduction And Context -- Part II: Case Studies -- Chapter 2: Kenya Case Study One -- Chapter 3: Guatemala Case Study -- Chapter 4: Ghana Case Study One -- Chapter 5: Pacific Island Case Study -- Chapter 6: Saudi Arabia Case Study -- Chapter 7: Philippines Case Study One -- Chapter 8: Kenya Case Study Two -- Chapter 9: Tanzania Case Study -- Chapter 10: Indonesia Case Study -- Chapter 11: Panama Case Study -- Chapter 12: Philippines Case Study Two -- Chapter 13: Bangladesh Case Study -- Chapter 14: Ghana Case Study Two -- Chapter 15: Ecuador Case Study -- Chapter 16: Thailand Case Study -- Chapter 17: Peru Case Study -- Part III: Evaluation And Synopsis -- Chapter 18: Evaluation And Synopsis.
    Kurzfassung: This book focuses on tropical coasts, which are highly vulnerable due to a multitude of stressors. Population growth is substantial, habitats are lost and biodiversity is reduced at an alarming rate, severely affecting many ecosystem services. This situation calls for sound coastal management and the effective engagement of all relevant stakeholders. About two decades ago the M.Sc. program ISATEC (International Studies in Aquatic Tropical Ecology) was created at Bremen University (Germany) to train young scientists for a professional engagement in the complex field of tropical coastal and resource management. This book provides a platform for those Alumni to report on their work experiences and findings in their home countries and covers all regions of the tropical belt. Part I of the book provides a short review of the state of the tropical ocean and its resources and of international attempts towards sustainable ocean management starting with the Rio Declaration on Environment and Development in 1992. Part II deals with country case studies, and part III focuses on an evaluation & synopsis of those contributions. Emerging key issues for management and conservation of the tropical coastal environments are presented and critical challenges on the path towards reaching the Sustainable Development Goals (SDGs) are discussed, as are the needs for enhancing research and capacity development. .
    Materialart: Online-Ressource
    Seiten: XII, 344 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031178795
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 63
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Drug delivery systems. ; Vaccines Biotechnology. ; Biomaterials. ; Immunotherapy. ; Biomedical Research. ; Drug Delivery. ; Biomaterials-Vaccines. ; Immunotherapy.
    Beschreibung / Inhaltsverzeichnis: Chapter 1 A short introduction to vaccines -- Chapter 2 Thermostability of vaccines -- Chapter 3 Drying technologies for vaccines -- Chapter 4 Aseptic spray drying technology -- Chapter 5 Design of experiment studies and scale-up -- Chapter 6 Applications of spray dried vaccines.-Chapter 7 Conclusions and future perspectives of spray-dried vaccines.
    Kurzfassung: This book addresses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale. The book aims to familiarize readers with the advances in vaccine spray drying technology to understand its application potential better. In particular, the book addresses the design of aseptic spray dryers, parameters affecting the spray drying process, sterile powder processing, cleaning procedures, and powder filling. In addition, different drying technologies for the production of dry powder vaccines are compared to discuss the unique capabilities of spray drying as a particle technology for vaccines. Special attention is given to research studies on spray-dried vaccines published over the past 30 years, with key findings from laboratory research to clinical trials. Potential applications of spray-dried vaccines and routes of administration are presented in detail. Finally, an outlook is given on how close the aseptic spray-drying of vaccines is to the market and the challenges that need to be overcome to be commercially successful. The book's target audience is academics, researchers, vaccine developers, industry experts, students, and possibly funders, including government agencies, who are active in the field. In addition, the book is a reference source for those involved in the vaccine formulation and biopharmaceutical processing industry.
    Materialart: Online-Ressource
    Seiten: XXIX, 589 p. 243 illus., 176 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031243233
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 64
    Schlagwort(e): Medicine Research. ; Biology Research. ; Radiology. ; Medical education. ; Anatomy. ; Biomedical Research. ; Radiology. ; Medical Education. ; Anatomy.
    Beschreibung / Inhaltsverzeichnis: Part I. Microscopy -- Chapter 1. Advances in Microscopy and Its Applications with Special Reference to Fluorescence Microscope: An Overview -- Chapter 2. Visualisation of Host-Pathogen Communication -- Chapter 3. A Review of Pathology and Analysis of Approaches to Easing Kidney Disease Impact: Host-Pathogen Communication and Biomedical Visualization Perspective -- Part II. Radiology and Patient Care -- Chapter 4. The Evolution of Equipment and Technology for Visualising the Larynx and Airway -- Chapter 5. The Impact of Technological Innovation on Dentistry -- Chapter 6. Advanced 3D Visualization and 3D Printing in Radiology -- Chapter 7. 3D Visualisation of the Spine -- Part III. Anatomy Education -- Chapter 8. Visualization in Anatomy Education -- Chapter 9. Visualizing Anatomy in Dental Morphology Education -- Chapter 10. Flashcards: The Preferred Online Game-Based Study Tool Self-Selected by Students to Review Medical Histology Image Content.
    Kurzfassung: This book highlights the integration of science and imaging and demonstrates how we can teach and learn in a much more accessible, innovative, and engaging way using technology. This volume is particularly focused on three main themes: advanced microscopy, anatomy education, and radiology visualisation related to patient care. The chapters pertaining to advanced microscopy convey complex biomedical information by visual means. These chapters provide both an overview on the principles of microscopy and specific applications of microscopy that have led to groundbreaking discoveries. Chapters pertaining to education summarise the recent trends in teaching gross and microscopic anatomy and emphasise the creation and use of novel tools to support student learning. Lastly, the radiological visualisation segment dives into the history of radiographic imaging and highlights the profound effect technology has had on improving patient outcomes. This volume will be of particular interest to many; the scope of this book encompasses medicine, dentistry, allied health professions, biomedical sciences, anatomy and histology education, radiology, and microscopy. Students, researchers, educators, and clinicians will learn something new, be stimulated to ask innovative questions, and be inspired to continue the technological advancements pushing science forward. .
    Materialart: Online-Ressource
    Seiten: XI, 224 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031264627
    Serie: Advances in Experimental Medicine and Biology, 1406
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 65
    Online-Ressource
    Online-Ressource
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    Schlagwort(e): Neurosciences. ; Zoology. ; Neuropsychology. ; Neuroscience. ; Zoology. ; Neuropsychology.
    Beschreibung / Inhaltsverzeichnis: 1 The search for the nature of the soul -- 2 The functional neuroanatomy of the limbic system -- 3 Neuro- and psychopharmacology -- 4 Neurophysiology -- 5 Developmental neurobiology -- 6 Emotion, motivation, personality and their neurobiological foundations -- 7 Neurobiological consequences of early stress experiences -- 8 Psychological and neurobiological foundations of consciousness -- 9 Nature, diagnosis and classification of mental illness -- 10 Psyche and mental illness - addiction -- 11 Psychotic illness ("schizophrenia") -- 12 Affective disorders using the example of unipolar depression -- 13 Anxiety disorders -- 14 Neuropsychotherapy - psychotherapy methods and their effects -- 15 Psychoneuroscience and its significance for practice. .
    Kurzfassung: The textbook builds a bridge between the "neurosciences" (theoretical and experimental neurobiology, neurology) and the "psychosciences" (psychology, psychiatry, psychotherapy) and aims to help provide the other disciplines with the most important and scientifically validated knowledge in an understandable form. The question of how mental experience and brain processes relate to each other has long been considered mysterious. In this book you will learn, based on the latest scientific findings, that the two areas form an indissoluble unity, even if we experience and study them differently. We present this unity in concrete terms in psychological-neurobiological theory and psychiatric-psychotherapeutic practice. We treat the principles of neurobiological excitation and information processing, the structure and function of the limbic system, the development of the personality and the interaction of genetic-epigenetic factors and prenatal and postnatal environmental influences, which may be favourable or unfavourable. On this basis, the exemplary presentation of important mental disorders such as addictive disorders, schizophrenic disorders, affective disorders and anxiety disorders takes place. Finally, following in the footsteps of the eminent psychotherapist Klaus Grawe, the concept of "neuropsychotherapy" is introduced and it is shown why psychiatry-psychotherapie and neurobiology belong together and can enrich each other. Our psychoneuroscientific approach paints a picture of man that is not based on opposites, but on an integration of psyche, brain, behavior and experience. The editors Prof. Dr. phil. Dr. rer. nat Gerhard Roth researches and teaches at the Institute for Brain Research, University of Bremen. "Psyche, personality and brain form an inseparable unit, even if we experience them differently". Prof. Dr. med. Dr. phil. Andreas Heinz is Clinic Director at the Department of Psychiatry and Psychotherapy at Charité Berlin. "The interplay of neurobiology, behavior and subjective experience is illuminated by new methods and models." Prof. Dr. med. Dr. phil. Henrik Walter heads the research area "Mind and Brain" at the Department of Psychiatry and Psychotherapy at Charité Berlin and is the deputy medical director of the clinic. "Neuroscience education in the practice of psychiatry and psychotherapy is increasingly becoming a matter of course - and that's a good thing." This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Materialart: Online-Ressource
    Seiten: XIV, 371 p. 61 illus., 57 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783662657744
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 66
    Schlagwort(e): Medicine Research. ; Biology Research. ; Human physiology. ; Cancer. ; Cancer Treatment. ; Virology. ; Therapeutics. ; Biomedical Research. ; Human Physiology. ; Cancer Biology. ; Cancer Therapy. ; Virology. ; Therapeutics.
    Beschreibung / Inhaltsverzeichnis: 1. Implications of renin-angiotensin system in health and disease -- 2. Renin angiotensin system and aging -- 3. The interplay of the renin-angiotensin system and solid organ transplantation -- 4. Correlation between renin angiotensin system and infectious disease -- 5. Emerging contributions of endocrine pathophysiology in virus-related infectious disease -- 6. Understanding the renin-angiotensin system in coronavirus disease 2019 -- 7. Metabolomics approach in differentiating RAS responses in ARDS (Acute respiratory distress syndrome) and SAR-CoV-2 -- 8. A Comprehensive review of the impact of the renin angiotensin system in the liver, lung, infectious diseases and cancers -- 9. Application of biosensors for monitoring changes in renin angiotensin system (RAS) in cancers and lung diseases -- 10. Bioinformatics study on renin angiotensin in lung, and liver cancer using plant-based extracts -- 11. Role of renin-angiotensin system in the pathogenesis and progression of non-alcoholic fatty liver -- 12. The classical and nonclassical renin-angiotensin-aldosterone system in liver cirrhosis -- 13. Renin-angiotensin-aldosterone system role in organ fibrosis -- 14. Role of renin angiotensin-aldosterone system in kidney homeostasis -- 15. Renin-angiotensin system in chronic kidney disease: Implications in stroke outcome -- 16. The renin-angiotensin system and cancer -- 17. Renin-angiotensin system and cancer: From laboratory to clinics -- 18. Role of renin-angiotensin system in cancer cachexia -- 19. Renin angiotensin system activity in different cancers: Mechanistic insight and preclinical studies -- 20. The new dimension of the renin-angiotensin system in the hallmarks of cancer -- 21. Renin-angiotensin system in hematological malignancies -- 22. Renin angiotensin system (RAS): The common thread between cancer and heart failure -- 23. Renin-angiotensin system: a potential therapeutic target for colorectal cancer -- 24. Anticancer role of natural phenolic acids by targeting angiotensin-converting enzyme (ACE) -- 25. Angiotensin-(1-7): A Prospective Cancer Therapeutic.
    Kurzfassung: This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.
    Materialart: Online-Ressource
    Seiten: XX, 498 p. 70 illus., 63 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031236211
    Serie: Advances in Biochemistry in Health and Disease, 25
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 67
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    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Ecology . ; Oceanography. ; Environmental education. ; Welfare economics. ; Freshwater and Marine Ecology. ; Biodiversity. ; Biooceanography. ; Environmental and Sustainability Education. ; Social Economy.
    Beschreibung / Inhaltsverzeichnis: 1. The future of food from the sea -- Chapter 2.The Expected Impacts of Climate Change on the Ocean Economy -- Chapter 3. What Role for Ocean-Based Renewable Energy and Deep-Seabed Minerals in a Sustainalble Future? -- Chapter 4. The Ocean Genome: Conservation and the Fair, Equitable and Sustainable Use of Marine Genetic Resources -- Chapter 5. Leveraging Multi-Target Strategies to Address Plastic Pollution in the Context of an Already Stressed Ocean -- Chapter 6. Technology, Data and New Models for Sustainably Managing Ocean Resources -- Chapter 7. Coastal Development: Resilience, Restoration and Infrastructure Requirements -- Chapter 8. National Accounting for the Ocean and Ocean Economy -- Chapter 9. Ocean Finance -- Chapter 10. Critical Habitats and Biodiversity: Inventory, Threshold and Governance -- Chapter 11. The Human Relationship with Our Ocean Planet -- Chapter 12. The Ocean Transition: What to Learn from System Transitions -- Chapter 13. Towards Ocean Equity -- Chapter 14. Integrated Ocean Management -- Chapter 15. Illegal, Unreported and Unregulated Fishing and Associated Drivers -- Chapter 16. Organised Crime Associated with Fisheries -- Chapter 17. The Ocean as a Solution to Climate Change: Five Opportunities for Action -- Chapter 18. A Sustainable Ocean Economy for 2050: Approximating Its Benefits and Costs -- Chapter 19. A Sustainable & Equitable Blue Recovery to the COVID-19 Crisis -- Chapter 20. Ocean Solutions That Benefit People, Nature and the Economy -- Chapter 21. Transformations for a Sustainable Ocean Economy: A Vision for Protection, Production and Prosperity.
    Kurzfassung: Home to over 80 percent of all life on Earth, the ocean is the world’s largest carbon sink and a key source of food and economic security for billions of people. The relevance of the ocean for humanity's future is undisputed. However, the ocean’s great potential to drive economic growth and equitable job creation, sustain healthy ecosystems, and mitigate climate change is not yet fully recognised. Lack of awareness of this potential as well as management and governance challenges pose impediments. Until these impediments are removed, ocean ecosystems will continue to be degraded and opportunities for people lost. A transition and a clear path to a thriving and vibrant relationship between humans and the ocean are urgently needed. This open access collection of papers and reports identifies a path that is inspired by science, energised by engaged people, and emboldened by visionary leaders. These assessments of knowledge are commissioned by the High Level Panel for a Sustainable Ocean Economy (Ocean Panel), which was established in September 2018 as a unique initiative led by heads of state and government from around the world, to showcase the latest leading-edge science, knowledge and state-of-the-art thinking on key ocean issues. Altogether, The Blue Compendium offers innovative ocean solutions in technology, policy, governance, and finance realms, that could help accelerate a transition to a more sustainable and prosperous relationship with the ocean. The comprehensive assessments have already informed policy making at the highest levels of government and motivated an impressive array of responsive and ambitious action across a growing network of leaders in business, finance and civil society. .
    Materialart: Online-Ressource
    Seiten: XII, 915 p. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031162770
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 68
    Schlagwort(e): Medicine Research. ; Biology Research. ; Biophysics. ; Biomechanics. ; Immunology. ; Bones. ; Biomedical engineering. ; Biomedical Research. ; Biophysics. ; Biomechanics. ; Osteoimmunology. ; Biomedical Engineering and Bioengineering.
    Beschreibung / Inhaltsverzeichnis: Preface (Brianne K. Connizzo, Lin Han, Robert L. Sah) -- Scientific Impact -- Chapter 1. Aggrecan and Hyaluronan: The infamous Cartilage Polyelectrolytes- Then and Now (Anna Plaas, Meghan Moran, John Sandy, Vincent Hascall) -- Chapter 2. Understanding the Influence of Local Physical Stimuli on Chondrocyte Behavior (Byumsu Ki, Lawrence J. Bonassar) -- Chapter 3. Multiscale In Silico Modeling of Cartilage Injuries (Rami K. Korhonen, Atte S.A. Eskelinen, Gustavo A. Orozco, Amir Esrafilian, Cristina Florea, and Petri Tanska) -- Chapter 4. In Vitro Models and Proteomics in Osteoarthritis Research (Martin Rydén, Patrik Önnerfjord) -- Chapter 5. Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration (Chao Wang, Elizabeth R. Kahle, Lin Han) -- Chapter 6. Computational Modelling for Managing Pathways to Cartilage Failure (Saeed Miramini, David W. Smith, Bruce S. Gardiner, Lihai Zhang) -- Chapter 7. Gene Delivery to Chondrocytes (Christopher V. Nagelli, Christopher H. Evans, Rodolfo E. De la Vega) -- Chapter 8. Mechanical Articular Cartilage Injury Models and Their Relevance in Advancing Therapeutic Strategies (Bodo Kurz, Melanie L Hart, Bernd Rolauffs) -- Chapter 9. Hip Osteoarthritis: Bench to Bedside Perspective (Young-Jo Kim) -- Chapter 10. Harnessing Growth Factor Interactions to Optimize Articular Cartilage Repair (Stephen B. Trippel) -- Personal Tributes -- Index.
    Kurzfassung: This is an open access book. In honor of his 75th birthday, we reflect on the impact of the pioneering work of Alan Grodzinsky and his laboratory. This volume includes in-depth discussions of tissue electromechanics, mechanobiology and biomechanics, and matrix biology in addition to the latest advancements in understanding the pathogenesis, progression and treatment of osteoarthritis. Unique to this volume, we overview decades of groundbreaking research that set the stage for the latest efforts in the field, highlighting the legacy of one researcher and their trainees.
    Materialart: Online-Ressource
    Seiten: XIV, 173 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031255885
    Serie: Advances in Experimental Medicine and Biology, 1402
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 69
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    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Medical genetics. ; Bioinformatics. ; Neuroscience. ; Medical Genetics. ; Bioinformatics. ; Computational and Systems Biology.
    Beschreibung / Inhaltsverzeichnis: 1-Attitudes and smoking prevalence among undergraduate students in central Greece -- 2-Care of patients with Alzheimer’s disease -- 3-Regulation of antioxidant enzymes levels in rat brain -- 4-NIRS-based assessment of cerebral oxygenation during high definition anodal transcranial direct current stimulation in patients with posttraumatic encephalopathy -- 5-Cerebral critical closing pressure at concomitant traumatic brain injury -- 6-The role of inflammatory biomarkers as a diagnostic tool for possible late-life cognitive decline and dementias -- 7-The Development of Antisense RNA Treatments using Engineered Protein Substrates -- 8-Biomarker-driven analysis using high-throughput approaches in neuroinflammation and neurodegenerative diseases -- 9-Sensitive and Stereo specific high-performance liquid chromatographic method for flurbiprofen in human plasma -- 10-Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study -- 11-Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological Voices in Parkinsonian Patients -- 12-Effects of an 8-Week Stress Management Program in Women with Breast Cancer: A Randomized Controlled Trial -- 13-The Rosenberg Self-Esteem Scale: Translation and Validation in the Greek Language in Adolescents -- 14-Stress system activation analysis in Greek female adolescents: a bioimpedance study -- 15-Kisspeptin and the genetic obesity interactome -- 16-The importance of diagnostic and prognostic biomarkers identification and classification towards understanding ALS pathogenesis -- 17-Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia -- 18-Ebola virus disease and current therapeutic strategies; A review -- 19-Hyperbaric Oxygen Therapy effect on “Kinesia Paradoxa” Brain Circuits -- 20-Early and Very Early GRIM19 and MCL1 Expression are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line -- 21-Phospholipid Fatty Acid Profile of Spirulina platensis -- 22-Chronic systemic inflammation measured by bioimpedance technology before and after sleeve gastrectomy: a feasibility study -- 23-Synthesis and Biological Evaluation Substituted Thiophene Derivatives -- 24-Force spectroscopy in mechanical protein domains unfolding -- 25-Investigating the genetic component of Parkinson’s Disease -- 26-Urticaria from the Neurodermatological Perspective: A Temporal Analysis of Urticaria and Cognition -- 27-Novel Low-Noise CMOS Bioamplifier for the Characterization of Neurodegenerative Diseases -- 28-The Kentucky Inventory of Mindfulness Skills in Greek Undergraduate and Postgraduate Students -- 29-Synthesis, in silico stuiesand biological evaluation of 1, 3 ,4 oxadiazino indole derivatives -- 30-Designing and screening of new schiff bases of indole derivatives for anti-bacterial activity by in-silico methods and docking studies -- 31-Use of vitamin D bolus in fortified juice for improving vitamin D status in children with Cerebral Palsy -- 32-Microbes and the games they play -- 33-Impurity Profiling and Identification of 2,6 diisopropylphenol by Raman spectroscopy -- 34-Cultural Accommodation of the Strengthening Families Program for Parents and Young Adolescents 10-14: Greek Phase I & II Study -- 35-The effect of nutrients on Alzheimer’s disease biomarkers: A metabolomic approach -- 36-The impact of exercising in the quality of life of people with Aementia-Alzheimer disease -- 37-Advanced Health Technologies and Nanotechnologies in Neurodegenerative Diseases -- 38-Phenotype and genotype study in a case of frontometaphyseal dysplasia 1 -- 39-Craniofacial and neurological phenotype in a case of oculodentodigital syndrome -- 40-Clinical and molecular study of common thrombophilia mutation prothrombin G20210A -- 41-Prenatal genetic testing for X-linked hypohidrotic ectodermal dysplasia -- 42-Preimplantation genetic testing for spastic paraplegia type 3 -- 43-Synthesis, anti-inflammatory activity and in-silico studies of some new 3-({P-DIMETHYLAMINO}BENZYLIDENE YDRAZINYLIDENE)-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES -- 44-Design, characterization and docking studies of some novel isatin derivatives for anticonvulsant and antidepressant activity -- 45-Skin mirrors Brain: A Chance for Alzheimer’s Disease Research -- 46-Mitochondrial homeostasis in neurodegeneration and ageing -- 47-The Alzheimer's Disease Chronicles: will evidence triumph over adversity? -- 48-Liposomes: Production Methods and Application in Alzheimer’s Disease -- 49-Developing Treatments for Alzheimer’s and Related Disorders with Precision Medicine: A Vision -- 50-Biomarkers and Precision Medicine in Alzheimer’s Disease -- 51-The role of microRNAs in thrombosis -- 52-Photo-oxygenation: an innovative new therapeutic approach against amyloidoses.
    Kurzfassung: The 5th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Neuroscientific Advances.
    Materialart: Online-Ressource
    Seiten: XXXI, 673 p. 58 illus., 50 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031319860
    Serie: Advances in Experimental Medicine and Biology, 1425
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 70
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    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Cancer. ; Tumors Immunological aspects. ; Biomedical Research. ; Cancer Biology. ; Cancer Microenvironment. ; Tumour Immunology.
    Beschreibung / Inhaltsverzeichnis: Chapter 1: Interactions in cancer ecosystem -- Chapter 2: Local niche construction -- Chapter 3: Pre-metastatic niche -- Chapter 4: Emerging concepts in cluster metastasis -- Chapter 5: Neuronal regulation in cancer ecosystem -- Chapter 6: Endocrinal regulation in cancer ecosystem -- Chapter 7: Innate immune system in cancer ecosystem -- Chapter 8: Adaptive immune system in cancer ecosystem -- Chapter 9: Inflammation in cancer ecosystem -- Chapter 10: Metabolic regulation in cancer ecosystem -- Chapter 11: Vascular regulation in cancer ecosystem -- Chapter 12: Microbial interaction in cancer ecosystem -- Chapter 13: Viral interaction in cancer ecosystem -- Chapter 14: Evolution of cancer ecosystem -- Chapter 15: Driving force of cancer ecosystem -- Chapter 16: Modeling, visualizing and subtyping the cancer ecosystem -- Chapter 17: Bio-engineering methods to mimic cancer ecosystem -- Chapter 18: Cancer ecosystem-directed therapeutic strategies.
    Kurzfassung: This book intends to report new concept of onco-spheres in cancer ecosystem. Onco-spheres are defined as where cancer cells (living organisms) dynamically interact with nontumor cellular (other living organisms) and noncellular components (non-living environmental factors) in the ‘host’ internal environment (habitat) to construct a self-sustainable cancer ecosystem, which can be scoped at three different levels: primary/regional, distal and systemic onco-spheres. Cancer cells should be conceived as ‘living organisms’, interacting with cellular or noncellular components in the host internal environment, not only with the local tumor microenvironment (TME) but also constantly communicating with a distant organ niche as well interacting with the host’s nervous, endocrine and immune systems, to construct a self-sustainable ‘biosphere’, as we termed the tumor ecosystem. By looking at the interaction of cancer and host as a unique ecosystem, we will use ecology principles to further delineate the features of the dynamics of the tumor ecosystem. As the pioneer in proposing this concept, we feel that this full-scale overview of the tumor ecosystem is able to inform the readers about this concept, and to pave the way for designing novel therapeutic strategies on actionable targets within tumor ecosystem. The book is likely to be of interest to immunologist, biologist, medical students, researchers and general public who wish to learn more on this new concept of tumor ecosystem, and how this could be applied in many fields of research.
    Materialart: Online-Ressource
    Seiten: XIX, 701 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819911837
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 71
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    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Neurology . ; Nanowires. ; Neuropharmacology. ; Neuroscience. ; Neurology. ; Nanowires. ; Neuropharmacology.
    Beschreibung / Inhaltsverzeichnis: Section I: Neurodegenerative diseases -- Chapter 1: Nanowired delivery of cerebrolysin together with antibodies to amyloid beta peptide, phosphorylated tau and tumor necrosis factor alpha induces superior neuroprotection in Alzheimer's disease brain pathology exacerbated by sleep deprivation -- Chapter 2: Nanodelivery of histamine H3/H4 receptor modulators BF2649 and clobenpropit with antibodies to amyloid beta peptide in combination with alpha synuclein reduces brain pathology in Parkinson's disease -- Chapter 3: Co-administration of nanowired DL-3-n-butylphthalide (DL-NBP) together with mesenchymal stem cells, monoclonal antibodies to alpha synuclein and TDP-43 (TAR DNA-binding protein 43) enhance superior neuroprotection in Parkinson's disease following concussive head injury -- Chapter 4: Neuroprotective effects of nanowired delivery of cerebrolysin with mesenchymal stem cells and monoclonal antibodies to neuronal nitric oxide synthase in brain pathology following Alzheimer’s disease exacerbated by concussive head injury -- Section II: Central Nervous system Trauma -- Chapter 5: Co-administration of nanowired monoclonal antibodies to inducible nitric oxide synthase and tumor necrosis factor-alpha together with antioxidant H-290/51 reduces SiO2-nanoparticles induced exacerbation of pathophysiology of spinal cord trauma -- Chapter 6: Nanowired delivery of cerebrolysin with mesenchymal stem cells attenuates heat stress induced exacerbation of neuropathology following brain blast injury -- Chapter 7: Co-administration of nanowired oxiracetam and neprilysin with monoclonal antibodies to amyloid beta peptide and p-tau thwarted exacerbation of brain pathology in concussive head injury at hot environment -- Section III. Stress and Drugs of abuse -- Chapter 8: Nanowired delivery of mesenchymal stem cells with antioxidant compound H-290/51 reduces exacerbation of methamphetamine neurotoxicity in hot environment -- Chapter 9: TiO2-nanowired delivery of Chinese extract of Gingko biloba EGb-761 and bilobalide BN-52021 enhanced neuroprotective effects of cerebrolysin following spinal cord injury at cold environment -- Chapter 10: Nanowired delivery of curcumin attenuates methamphetamine neurotoxicity and elevates levels of dopamine and brain derived neurotrophic factor.
    Kurzfassung: This book covers the use of nanomedicine in the delivery of neuroprotective agents, including pharmacological drugs, stem cells, neurotrophic factors, monoclonal antibodies and enzymes to induce greater beneficial effects in neurologic diseases. Thus, the main purpose of the book is to explore the delivery of drugs either alone or in combination with stem cells to enhance neuroprotection in neurological diseases. Brain pathology associated with acute trauma such as head injury and brain blast injury can also be managed using novel treatment strategies. In addition, emphasis is made that standard patterns of brain pathology may be complicated with multiple comorbidity factors where one agent alone is not sufficient to induce brain protection. Enzymes and antibodies may help in combination and enhance the efficacy when administered through nanotechnology. Progress in Nanomedicine in Neurologic Diseases will encourage further research in the field of neuroprotection, brain injury, neurodegenerative diseases, neuropharmacology, neuropathology, and neurology. Students and researchers along with policy makers, teachers and health care professionals may also benefit from the findings of the book for enhanced patients care.
    Materialart: Online-Ressource
    Seiten: XV, 418 p. 40 illus., 39 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031329975
    Serie: Advances in Neurobiology, 32
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 72
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    Singapore :Springer Nature Singapore :
    Schlagwort(e): Neurosciences. ; Developmental biology. ; Nervous system Diseases. ; Neuroscience. ; Developmental Biology and Stem Cells. ; Neurological Disorders.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. History, origin and types of neurological disorders -- Chapter 2. Mechanistic approach involved in the progression of Neurodegenerative disorders -- Chapter 3. Isolation, characterization and differentiation of stem cells -- Chapter 4. Role of Stem cells as a protective agent against neurological complications -- Chapter 5. Mesenchymal stem cells and their application against neurodegenerative disorders -- Chapter 6. iPSCs and their role in amelioration of neurodegenerative disorders -- Chapter 7. Isolation, characterization and detailed history of exosomes derived from stem cells and their epigenetic biology -- Chapter 8. Stem cells vs exosomes: promising therapeutic approach and biomarkers agent against neurodegenerative disorders -- Chapter 9. Role of stem cells and derived exosomes as a novel therapeutic agent against neuroinflammation and stroke -- Chapter 10. Role of stem cells and derived exosomes as a novel therapeutic agent against Alzheimer’s and Parkinson's disease -- Chapter 11. Role of stem cells and derived exosomes and associated signalling molecules involved in neuroprotection -- Chapter 12. Exosome as nanoparticles against neurodegenerative disorders.
    Kurzfassung: This book explores the therapeutic approaches of stem cells and stem cell-derived exosomes against neurodegenerative disorders (NDDs). The initial chapters introduce different neurodegenerative diseases and discuss the mechanistic aspects of their progression. The subsequent chapters cover strategies for the isolation, characterization, and differentiation of stem cells. In turn, the book reviews the protective role of stem cells against neurological disorders and examines regenerative approaches to treat neurological diseases using mesenchymal stem cells. The book also presents induced pluripotent stem cell (iPSC) technology for cellular therapy, drug screening, and in-vitro modeling of neurodegenerative diseases. Lastly, the book discusses the role of stem cells and derived exosomes as a novel therapeutic agent against Alzheimer's and Parkinson's disease and in associated signaling molecules involved in neuroprotection. This book is an invaluable source for researchers working towards understanding the potential of stem cell therapy in neurodegenerative disorders.
    Materialart: Online-Ressource
    Seiten: XIII, 327 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819938483
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 73
    Schlagwort(e): Neurosciences. ; Computational neuroscience. ; Biophysics. ; Science History. ; Neuroscience. ; Computational Neuroscience. ; Biophysics. ; History of Science.
    Beschreibung / Inhaltsverzeichnis: 1. Integrate and fire: RC circuits to model neurons and reward monkeys -- 2. Neuronal spike trains, stochastic point processes, and why George Gerstein’s papers are still worth reading -- 3. Visual Functions of Inferior Temporal Cortex -- 4. Early Days in the Gerstein Lab: Neuronal Plasticity in 1, 2, and 3 Dimensions -- 5. Patterns in Spike Trains -- 6. Introduction to the Gravity Papers -- 7. On correlations and interactions between neurons and with George Gerstein -- 8. Significance of Correlations between Spike Trains -- 9. Spatial-Temporal Spike Patterns -- 10. Does Cross Correlation Have a Unique Interpretation? -- 11. Neuronal Plasticity and my Experience Working with George L. Gerstein -- 12. Auditory Experiments and Modeling -- 13. Thinking about Analysis Methods with George in Philadelphia, Cambridge and Newcastle -- 14. Higher-order Correlations and Synfire Chains -- Nencki Award for George L. Gerstein.
    Kurzfassung: This book brings together a selection of papers by George Gerstein, representing his long-term endeavor of making neuroscience into a more rigorous science inspired by physics, where he had his roots. Professor Gerstein was many years ahead of the field, consistently striving for quantitative analyses, mechanistic models, and conceptual clarity. In doing so, he pioneered Computational Neuroscience, many years before the term itself was born. The overarching goal of George Gerstein’s research was to understand the functional organization of neuronal networks in the brain. The editors of this book have compiled a selection of George Gerstein’s many seminal contributions to neuroscience--be they experimental, theoretical or computational--into a single, comprehensive volume .The aim is to provide readers with a fresh introduction of these various concepts in the original literature. The volume is organized in a series of chapters by subject, ordered in time, each one containing one or more of George Gerstein’s papers.
    Materialart: Online-Ressource
    Seiten: XIII, 548 p. 253 illus., 29 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783030874476
    Serie: Springer Series in Computational Neuroscience,
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 74
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    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Lysine demethylation in pathogenesis -- Chapter 2. Targeting the LSD1/KDM1 Family of Lysine Demethylases in Cancer and Other Human Diseases -- Chapter 3. KDM2 demethylases as drug targets -- Chapter 4. Role of histone demethylase KDM3 (JMJD1) in transcriptional regulation and cancer progression -- Chapter 5. KDM4 demethylases as drug targets -- Chapter 6. KDM5 lysine demethylases in pathogenesis, from basic science discovery to the clinic -- Chapter 7. Context-dependent functions of lysine demethylases in physiology and disease -- Chapter 8. KDM7 demethylases as drug targets.
    Kurzfassung: This book provides a comprehensive summary of our current knowledge on lysine demethylases, a class of epigenetic regulators. It takes the reader on an exciting journey spanning the past two decades, starting from the initial discovery and characterization of these enzymes and leading up to the development of their small molecule modulators. These modulators have shown promise in clinical trials and hold great potential to improve patient outcomes. The book captures the progress made in this field and highlights the significant advancements that have paved the way for potential therapeutic applications. The book covers a wide range of topics, spanning both basic biology and clinical implications associated with lysine demethylases. It offers a comprehensive historical and conceptual framework for the discovery and characterization of similar epigenetic enzymes or modulators. Chapter one serves as an introductory overview, providing insights into the general characteristics and functions of lysine demethylases. In subsequent chapters, specifically chapters two to eight, each major family of lysine demethylases is individually explored in depth. By providing in-depth insights into the functional aspects of these enzymes, the book allows readers to grasp their significance in regulating cellular processes and influencing pathogenesis. Moreover, the book goes beyond fundamental knowledge and also explores the development of diagnostic and therapeutic strategies related to lysine demethylases. It highlights the potential for utilizing these enzymes as therapeutic targets for the treatment of various diseases, including cancer and infectious diseases. Additionally, the book highlights future directions aimed at further unraveling the roles of lysine demethylases and translating these findings into the clinic.
    Materialart: Online-Ressource
    Seiten: VII, 184 p. 35 illus., 28 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031381768
    Serie: Advances in Experimental Medicine and Biology, 1433
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 75
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical education. ; Materials Microscopy. ; Anatomy. ; Cytology. ; Education Data processing. ; Biomedical Research. ; Medical Education. ; Microscopy. ; Anatomy. ; Cell Biology. ; Computers and Education.
    Beschreibung / Inhaltsverzeichnis: Part I. Advances in Microscopy for Visualization, Education and Healthcare Practice -- Chapter 1. Visualizing the Invisible: Microscopy and How It Affects Our Understanding of Cells and Tissues -- Chapter 2. Morphometric Image Analysis and Its Applications in Biomedicine Using Different Microscopy Modes -- Chapter 3. The Shift in Power from Conventional to Digital and Virtual Microscopy -- Chapter 4. How Visualizations Have Revolutionized Taxonomy: From Macroscopic, to Microscopic, to Genetic -- Chapter 5. Bright New World: Principles of Fluorescence and Applications in Spectroscopy and Microscopy -- Chapter 6. An Introduction to Particle Tracking Techniques with Applications in Biomedical Research -- Chapter 7. An Exploration of the Practice of CT Modalities to Evaluate Anterior Cranial Deformities in Craniosynostosis -- Part II. Anatomical and Cell Biology Education -- Chapter 8. The Use of Biomedical Imaging in Visuospatial Teaching of Anatomy -- Chapter 9. Ultrasound Imaging for Musculoskeletal Research -- Chapter 10. Skill Acquisition in Histology Education.
    Kurzfassung: This edited book has a strong focus on advances in microscopy that straddles research, medical education and clinical practice. These advances include the shift in power from conventional to digital microscopy. The first section of this book covers imaging techniques and morphometric image analysis with its applications in biomedicine using different microscopy modes. Chapters highlight the rich development of fluorescence methods and technologies; particle tracking techniques with applications in biomedical research and nanomedicine; the way in which visualizations have revolutionized taxonomy from gross anatomy to genetics; and the psychology of perception and how it affects our understanding of cells and tissues. The book’s first section concludes by exploring the use of CT modalities to evaluate anterior deformities in craniosynostosis. In the second section of the book, chapters on anatomical and cell biology education explore the history of anatomical models and their use in educational settings. This includes examples in 3D printing and functional human anatomical models that can be created using easily available resources and the use of biomedical imaging in visuospatial teaching of anatomy; the novel use of ultrasound in medical education and practice; and skill acquisition in histology education using a flowchart called a ‘decision tree’. This book will appeal to histologists, microscopists, cell biologists, clinicians and those involved in anatomical education and biomedical visualization, as well as students in those respective fields.
    Materialart: Online-Ressource
    Seiten: XIV, 228 p. 107 illus., 94 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031368509
    Serie: Biomedical Visualization, 2
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 76
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Physiology. ; Ecology . ; Evolution (Biology). ; Anatomy, Comparative. ; Freshwater and Marine Ecology. ; Animal Physiology. ; Evolutionary Ecology. ; Animal Anatomy.
    Beschreibung / Inhaltsverzeichnis: PREFACE AND ACKNOWLEDGEMENTS -- SECTION I – IN THE BEGINNING -- CHAPTER 1. WADING IN ̶ INTRODUCTION TO THE FISH-BIRD -- General Discussion of Penguins and Substance of the Book -- An Impressive Number of Penguin Species: Evolution of Their Unique Capabilities -- Penguin Species Radiation and the Ontogeny of Their Watery World -- Penguin Evolution: Body Size and Climate -- Penguin Evolution: Radiation into Vacant Niches -- Penguin Evolution: Body Size and Crossing the Sea-Land Boundary -- CHAPTER 2. LAND AHOY! A TIRESOME BUSINESS -- Crossing the Land-Ocean Interface is Affected by Body Size -- Why and How Often do Penguins Come Ashore? -- Tying Land-life to the At-sea Life of Fish-Birds: Foraging and Breeding -- Success Vary with Prey Availability -- Molt ̶Necessary, Brief Respite from the Sea -- SECTION II – PENGUIN MARINE HAUNTS AND FOOD HABITS -- CHAPTER 3.FISH-BIRDS AT HOME IN THEIR OCEAN HABITATS -- Oceanographic Fronts and Water Masses Important to Penguins: General Discussion -- Penguins Require High Productivity Water Masses -- Large Scale: Oceanographic Boundaries and At-sea Distributions of Penguins -- Southern Boundary of the Antarctic Circumpolar Current -- Emperor and King penguins -- Adélie and Chinstrap penguins -- Antarctic Polar Front and Subantarctic Front -- Gentoo and Yellow-eyed penguins -- Macaroni and Royal penguins -- Northern and Southern Rockhopper, Fiordland, Snares penguins -- Subtropical Front and Continental Boundary Currents -- Galápagos, Humboldt, Magellanic, African penguins -- Little penguins -- Meso- and Small-Scale Ocean Processes Facilitating Penguin Exploits -- Island wakes -- Headland wakes -- Shelves and banks -- Submarine canyons -- Shelfbreak fronts -- Marginal ice zones -- Thermo-/haloclines -- CHAPTER 4. SEA FOOD ̶ THE FISH-BIRD MENU -- General Considerations -- Diet Quality: Survival in Cold Water -- Energy density of prey -- Prey size may or may not differ by penguin size -- Prey availability -- Diet Comparison among Penguin Species -- Polar/subpolar, mesopelagic penguins -- Subpolar, demersal/benthic, continental-shelf penguins -- Temperate, upper water column, continental-insular shelf penguins -- Polar, upper water column, continental shelf/slope penguins -- Subpolar, upper water column, continental slope/pelagic penguins -- Polar, upper water column, continental slope/pelagic penguins -- CHAPTER 5. ECOLOGICAL CONSEQUENCES OF DIET COMPOSITION -- Intraspecific Competition among Penguins -- Foraging Range is Key: General Discussion -- Penguin Species’ Central-Place Foraging Range Patterns -- Sex Differences in Foraging -- Interspecific Competition Involving Penguins -- Penguins Eat A lot! -- Competition between Penguin Species -- Competition between penguins and other seabirds -- Competition between penguins and marine mammals -- Competition between penguins and industrial fisheries -- SECTION III – THE HARDWARE OF A FISH-BIRD -- CHAPTER 6. THE SLIPPERY SHAPE, HOT AIR AND THE POWERHOUSE – HOW FISH-BIRDS SWIM -- Water – Hard Taskmaster -- The Four Forces Relevant to Penguins -- Vertical Forces – Weight and Upthrust -- Buoyancy: How Much Air Do Penguins Hold? -- Buoyancy and Bergmann’s Rule revisited -- Horizontal Forces: Drag -- The Interplay of Drag and Upthrust in Gliding Penguins -- The Drag Devil is in the Detail -- The Penguin Powerhouse -- How Penguins Swim -- The Effect of Upthrust and Body Angle on Penguin Thrust and Lift Forces -- Top Speeds; Power and Upthrust -- The Energy Costs of Swimming -- General considerations -- Specific considerations -- ’Sensible’ Swim Strategies and Costs of Transport -- Cruising speed and integrating speed with the cost of transport, -- and beyond -- CHAPTER 7. HOT PENGUINS ̶ COLD WATER -- Resting and Floating Penguins -- The Metabolic Rate of Floating Penguins -- Patterns of Heat Loss to the Sea -- Overall Body Insulation/Conductance -- The Nature of Penguin Insulation -- Active Penguins -- Activity Produces Heat -- Greater Depths Impose a Higher Heat Tax -- Consuming Prey Imposes a Heat Tax -- Embracing The Fish in the Fish-bird -- CHAPTER 8. FISH-BIRDS – THE INSIDE STORY -- Diving Physiology -- Surface issues – Uptake of oxygen -- Oxygen Management Underwater -- Role of the Air Spaces -- Gas Exchange to Body Tissues -- The Aerobic Dive Limit and Beyond -- The Importance of Size in Dive Performance -- Duration -- Depth -- Penguins Under Pressure – Beating the Squeeze and the Bends -- Barotrauma -- Beating the Bends -- A Gut Reaction in Fish-Birds -- Gastric Emptying -- Rotting Food -- The Eyes Have It -- SECTION IV – THE SOFTWARE OF FISH-BIRDS -- CHAPTER 9. EMBRACING THE DEPTHS - THE PENGUIN DIVE -- Submergence -- The time underwater – basic dive descriptors -- Dive profiles -- Dive distance-depth profiles -- Dive aspect ratios -- Horizontal dive directionality/tortuosity -- The Multifunctionality of Dives -- Basic dive types -- T-dives for travelling -- V-dives (water column assessment) -- P-dives (parabolic – prospecting with no prey capture) -- Po-dives (parabolic dives with circular trajectory) -- U-dives (depth-directed prospecting) -- W-dives/Up-dives (U-dives with prey pursuit) -- Depth Duration Effects Over Multiple Dives -- CHAPTER 10. FISH-BIRD STRATEGIES ̶ THE SEARCH FOR FICKLE PREY -- Decisions, Decisions, Decisions – How Fish-Birds Search for Prey -- Heading in the Right Direction -- Dealing with Prey Patchiness -- In-depth Considerations: -- Time-based efficiency -- Energy-based efficiency -- Superficial Considerations: Surface Pauses and Inspired Tactics -- Being Picky about Food -- Fish-Birds and Smart Strategies -- CHAPTER 11. THE FINAL SECONDS – HOW FISH-BIRDS CAPTURE PREY -- Prey Acquisition, a Departure from the Dive ‘Norm’ -- Performance Metrics for Prey Capture -- Catching Solitary Prey -- Changing buoyancy with depth affects prey capture strategies -- Prey pursuit against interfaces -- Exploiting Aggregated Prey -- Crustaceans -- Fish -- Non-corralling feeding behavior -- Clarity on Limitations of Penguin Vision -- SECTION V – PENGUINS IN A FICKLE ENVIRONMENT -- CHAPTER 12. TURNING THE TABLES – FISH-BIRDS ON THE MENU -- Basic Law of the Sea: Big Fish Eat Little Fish -- Seals as Predators -- Seals’ hunting behavior -- Penguins avoiding seals -- Fur Seals as Predators -- Sea Lions as Predators -- Killer Whales as Predators -- Sharks as Predators -- CHAPTER 13. PENGUINS ADJUSTING TO A CHANGING OCEAN -- Penguins Have Always Been Challenged by a Changing Ocean -- Prehistoric response to a changing ocean -- Possible prehistoric changes to penguins’ food web -- The Anthropocene: How will Penguins Cope, Now Also Dealing with Humans? -- Response to long-term climate change -- Response to short-term ocean climate variation -- Response to marine pollution -- CHAPTER 14. NOT FORGETTING ̶ -- The Social Side - Behavior and Communication at Sea -- Penguin flock fusion/cohesion -- Penguin flock fission/fragmentation -- Navigation -- Long range -- Medium to short-range -- Understanding the Daily ‘Wash’ -- Air flux in diving penguins, an aspect of ‘washing’ -- Are Auks Really ‘Northern Penguins’? -- Research Tags – the Flip Side for Evolutionarily-Honed Fish-Birds -- SECTION VI -- CHAPTER 15. PENGUINS ̶ WHY THE HYPE? -- Sources of Hype -- Us -- Many people -- Researchers -- The Transition -- The fascination of species -- Beyond the transition -- Role in Ecosystems -- Biomimicry -- Our Last Word.
    Kurzfassung: Centuries ago, when penguins were first encountered by European explorers, they were not thought to be birds but rather a fish-like relative. Subsequent accumulation of knowledge has shown penguins to be an avian species with unrivaled aquatic attributes, owing to a number of evolutionary adaptations: shape change, low drag, ability to regulate buoyancy, and extraordinary surface compliancy from their featheration. They are indeed the most extremely specialized diving bird, having given up flight (which otherwise is hugely advantageous) to the benefit of underwater prowess (such as speed, maneuverability and an ability to exploit an extraordinary range of depths). This flightlessness, however, also comes with costs that are substantial for a seabird (such as the inability to cover large distances quickly in reaction to ephemeral prey); and the energy needed to cope with moving through an aqueous environment, which is more resistant than air. For penguins, the high energetic costs in exploiting the ocean environment thus makes them especially sensitive to changes in food availability or their access to their prey. While a number of “penguin books” cover the natural history, mainly of breeding aspects, few address in much detail the incredible aquatic nature of these creatures. A huge amount of information has been amassed over recent past decades thanks to dramatic advances in microelectronics, bio-logging and maturation of some long-term studies of penguin life history. This work represents an integration of all these data with charts, maps and graphs, along with richly illustrated photos by experts in the field. .
    Materialart: Online-Ressource
    Seiten: XXII, 567 p. 216 illus., 198 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031339905
    Serie: Fascinating Life Sciences,
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 77
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    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Stem cells. ; Developmental biology. ; Biomedical Research. ; Stem Cell Biology. ; Developmental Biology and Stem Cells.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Hematopoietic Stem Cell Development in Mammalian Embryos -- Chapter 2. Hematopoietic Stem Cells and Their Bone Marrow Niches -- Chapter 3. Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis -- Chapter 4. Metabolism in Hematopoiesis and Its Malignancy -- Chapter 5. The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases -- Chapter 6. Ex vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells -- Chapter 7. N6-methyladenosine RNA Modification in Normal and Malignant Hematopoiesis -- Chapter 8. Immune System Influence on Hematopoietic Stem Cells and Leukemia Development -- Chapter 9. Learning from Zebrafish Hematopoiesis -- Chapter 10. Multi-lineage Differentiation from Hematopoietic Stem Cells -- Chapter 11. Gene Editing in Hematopoietic Stem Cells -- Chapter 12. Aging, Causes and Rejuvenation of Hematopoietic Stem Cells.
    Kurzfassung: This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic.
    Materialart: Online-Ressource
    Seiten: XV, 210 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819974719
    Serie: Advances in Experimental Medicine and Biology, 1442
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 78
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Bioclimatology. ; Oceanography. ; Pollution. ; Climatology. ; Freshwater and Marine Ecology. ; Climate Change Ecology. ; Ocean Sciences. ; Pollution. ; Climate Sciences.
    Beschreibung / Inhaltsverzeichnis: Part I Climate Change and the Ocean -- 1 Introduction to Climate Change -- 2 Warming, Acidification and Deoxygenation of the Ocean -- 3 Blue Carbon -- 4 Fishes and Carbon -- 5 Whales and Climate -- Part II Fisheries and Food from the Ocean -- 6 State of the World’s Fisheries—Legal Overfishing -- 7 Fish Crimes (Illegal, Unreported, and Unregulated Fishing) -- 8 Aquaculture: Farming Food from the Sea -- 9 Shark Fishing and Shark Finning -- 10 The Move to Sustainable Seafood -- Part III Ocean Pollution -- 11 Plastic and the Ocean -- 12 Shipping and the Ocean -- 13 Oil Spills -- 14 Ocean Noise Pollution -- Part IV Threatened and at Risk Ocean Habitats -- 15 The Deep Sea -- 16 Coral Reefs -- 17 Antarctica and the Southern Ocean: Our Last Great Wilderness -- 18 Top of theWorld—The Arctic Ocean -- 19 Coastal Habitats -- Part V How We Manage the World’s Oceans -- 20 Ocean Governance -- 21 Marine Protected Areas -- 22 Ensuring a Sustainable and Equitable Blue Economy -- 23 Leveraging Innovation for Ocean Conservation -- Part VI Humans and the Ocean -- 24 Oceans and Communities -- 25 Tourism and the Ocean -- 26 The Aquarium Trade -- 27 Marine Animal Welfare: A Growing Concern -- 28 Ocean and Human Health -- Part VII Diversity and Inclusion in the Ocean Space -- 29 Gender and the Ocean: Marine Resources and Spaces for All -- 30 Racial-Gender Disparities, and the Impacts of Coloniality in Ocean Science on BIPOC Women -- 31 Lived Experiences: Editors’ Note -- Part VIII Inspiring Voices -- 32 Inspiring Voices: Inka Cresswell, Jamila Janna, Merrisa Naidoo, Louisa Ponnampalam, Vatosoa Rakotondrazafy, Jo Ruxton MBE, Marilyn Slett, Patima Tungpuchayakul -- Index.
    Kurzfassung: The Ocean and Us provides an overview of our contemporary understanding of the ocean and all the ways our lives interact with it. It is intended for everyone with an interest in our blue planet. The book brings together the expertise of over 35 ocean specialists from around the world. It explores a wide variety of themes including the importance of a healthy ocean in the fight to halt and contain climate change. It covers issues such as overfishing and pollution, as well as emerging themes such as the blue economy, marine animal welfare and how we can leverage innovation to protect the ocean. The book provides an overview of some of the world’s iconic threatened and at risk ocean ecosystems, and outlines current governance structures and ocean management tools. It also discusses the important social dimensions between people and the ocean, such as ocean and human wellbeing, communities and the ocean, and who gets to participate in the ocean space. The book aims to enhance ocean literacy by making specialist concepts accessible to non-experts, with a view to empowering concerned citizens everywhere to come into action for the ocean, and pave a better way forward for humanity.
    Materialart: Online-Ressource
    Seiten: XXII, 370 p. 149 illus., 146 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031108129
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 79
    Schlagwort(e): Neurosciences. ; Otorhinolaryngology. ; Neuroscience. ; Otorhinolaryngology.
    Beschreibung / Inhaltsverzeichnis: Soundscape – The Development of a New Discipline -- Soundscape: A Construct of Human Perception -- Soundscape: The Holistic Understanding of Acoustic Environments -- Soundscape and Urban Planning -- Architectural Soundscapes: Theories, Methods, and Practice -- Psychoacoustics in Soundscape Research -- Measurements and Techniques in Soundscape Research -- Triangulation as a Tool in Soundscape Research -- Soundscape and Health -- Hospital Soundscape -- How to Put Soundscape into Practice.
    Kurzfassung: The concept of “Soundscape” includes all sounds in an environment and focuses on the interrelationship between person, activity and place, both in space and time. The goal of this volume is to present and review the developments in the field of Soundscape, reflecting standardization procedures and diverse applications. Soundscape – The Development of a New Discipline Brigitte Schulte-Fortkamp, and André Fiebig Soundscape: A Construct of Human Perception André Fiebig Soundscape: The Holistic Understanding of Acoustic Environments Brigitte Schulte-Fortkamp and Pamela Jordan Soundscape and Urban Planning Bennett M. Brooks Architectural Soundscapes: Theories, Methods, and Practice Gary W. Siebein, and Keely M. Siebein Psychoacoustics in Soundscape Research Klaus Genuit, Brigitte Schulte-Fortkamp, and André Fiebig Measurements and Techniques in Soundscape Research Giovanni Brambilla, and André Fiebig Triangulation as a Tool in Soundscape Research Dick Botteldooren, Bert De Coensel, and Francesco Aletta, Jian Soundscape and Health Peter Lercher, and Angel M. Dzhambov Hospital Soundscapes Ilene Busch-Vishniac, and Erica Ryherd How to Put Soundscape into Practice André Fiebig, andBrigitte Schulte-Fortkamp .
    Materialart: Online-Ressource
    Seiten: XVII, 330 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031227790
    Serie: Springer Handbook of Auditory Research, 76
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 80
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Blockchains (Databases). ; Medical care. ; Medical Ethics. ; Medical policy. ; Biomedical Research. ; Blockchain. ; Health Care. ; Medical Ethics. ; Health Policy.
    Beschreibung / Inhaltsverzeichnis: 1. Introductory chapter: Early applications and evolution of blockchain implementations in medicine -- 2. Can Blockchain Technology Change Contemporary Medicine As It Is Currently Understood? -- 3. The Current State of Healthcare Information Exchange (HIE) and Proposing a Blockchain HIE Infrastructure -- 4. An amalgamation of blockchain and connected health for combating COVID-19 -- 5. Applications of Blockchain Technology in the COVID-19 Era. 6. Distributed Ledgers and Immunity Passports: The Intersection of Clinical Medicine and Digital Technology -- 7. Digital Identity, Computational Reliabilism, and the Future of IOMT: Epistemic Reasoning and The Role of Blockchain in Removing Human Tampering from Pharmacovigilance Decision Making -- 8. Potential implementations of blockchain technology in patient safety: A high-level overview -- 9. Blockchain in Medical Education -- 10. Blockchain in Education: Linking Competency Assessment with Credentialing -- 11. Optimizing Blockchain Technology in Academic Medicine -- 12. Distributed Research Networks -- 13. Use of Blockchain Technology for Implantable Medical Device Tracking -- 14. Application of Blockchain Technology in Healthcare Supply Chains.
    Kurzfassung: Blockchain technology (BT) is quietly transforming the world, from financial infrastructure, to the internet-of-things, to healthcare applications. With increasing penetration of BT into various areas of our daily lives, the need arises for better awareness and greater knowledge about the capabilities, benefits, risks, and alternatives to distributed ledger applications. It is hoped that current book will be one of the pioneering collections focusing on blockchain implementations in the area of healthcare, with specific aim to present content in an easy-to-understand and readily accessible way for typical end-users of blockchain-based applications. There are important areas within the fabric of modern healthcare that stand to benefit from implementations of BT. These areas include electronic medical records, quality control, patient safety, finance, device tracking, biostamping/biocertification, redundant storage of critical data, health and liability insurance, medication utilization tracking (including opioid and antibiotic misuse), financial transactions, academics/education, asset tokenization, public health and pandemics, healthcare provider credentialing, and many other potential applications. The ultimate goal of the proposed book would be to provide an integrative, easy-to-understand, and comprehensive picture of the current state of blockchain use in healthcare while actively engaging the reader in a forward-looking, exploratory approach toward future developments in this space. To accomplish this goal, an expert panel of contributors has been assembled, featuring scholars from top global universities and think-tanks.
    Materialart: Online-Ressource
    Seiten: VIII, 250 p. 33 illus., 17 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031145919
    Serie: Integrated Science, 10
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 81
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    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Measurement. ; Measuring instruments. ; Biophysics. ; Biomedical Research. ; Measurement Science and Instrumentation. ; Biophysics.
    Beschreibung / Inhaltsverzeichnis: 1. Principles of molecular recognition -- 2. Theoretical Aspects -- 3. Molecular Recognition Units in Sensor Constructions -- 4. Binding blocks and Interfaces Designed for Sensing -- 5. Probing the properties of continuous media and interfaces -- 6. Detection of Ions and Low-molecular Targets -- 7. Detection of Biological Macromolecules and Recognition of harmful microbes -- 8. Sensing Inside the Living Cells -- 9. Ex-vivo Clinical Diagnostics -- 10. Imaging in vivo -- 11. Theranostics: Combining Targeting, Imaging and Therapy -- 12. Opening new horizons.
    Kurzfassung: Fluorescence is the most popular technique in chemical and biological sensing because of its ultimate sensitivity, high temporal and spatial resolution and versatility that enables imaging within the living cells. It develops rapidly in the directions of constructing new molecular recognition units, new fluorescence reporters and in improving sensitivity of response up to detection of single molecules. Its application areas range from control of industrial processes to environment monitoring and clinical diagnostics. This book provides systematic knowledge of basic principles in design of fluorescence sensing and imaging techniques together with critical analysis of recent developments. Being a guide for students and young researchers, it also addresses professionals involved in active basic and applied research. Making a strong link between education, research and product development, this book discusses prospects for future progress.
    Materialart: Online-Ressource
    Seiten: XXI, 761 p. 290 illus., 260 illus. in color. , online resource.
    Ausgabe: 3rd ed. 2023.
    ISBN: 9783031190896
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 82
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    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Neurosciences. ; Nervous system Diseases. ; Developmental neurobiology. ; Cognitive neuroscience. ; Neuroscience. ; Neurological Disorders. ; Development of the Nervous System. ; Cognitive Neuroscience.
    Beschreibung / Inhaltsverzeichnis: PART I. Iron, Brain Function and Behavior -- Chapter 1. Iron and Neuro-cognition -- Chapter 2. The Interplay Between Iron and Oxidative Stress in Brain Neurodegenerative Diseases -- Chapter 3. Specific Nutritional Therapeutic Approaches Targeting Iron Overload and Other Hallmarks of Brain Degenerative Diseases -- Chapter 4. Mediterranean Diet and Neuro-Cognition: Focus on Alzheimer disease -- PART II Brain disorders related to Iron -- Chapter 5. The Critical Roleplay of Iron Neurochemistry in Progression of Parkinson’s Disease -- Chapter 6. Iron-Calcium Crosstalk in Neurodegenerative Diseases -- Chapter 7. Iron and Alzheimer’s Disease -- Chapter 8. Iron and Multiple Sclerosis -- Chapter 9. Iron and Epilepsy -- Chapter 10. Iron and Subarachnoid Hemorrhage -- Chapter 11. Iron deficiency and psychiatric disorders -- Chapter 12. Iron and Neuro-developmental Disorders -- Chapter 13. Iron and Neuropathies.
    Kurzfassung: This book explores the molecular mechanisms of iron hemostasis in the brain and discusses the cognitive and behavioral implications of iron deficiency. It presents the effect of iron dysregulation on neurophysiological mechanisms. The book provides an overview of iron metabolism and homeostasis at the cellular level and its regulation at the mRNA translation level. It emphasizes the importance of iron for brain development in fetal and early life in preterm infants. Further, it presents iron metabolism as a therapeutic target for novel pharmacological treatment against neurodevelopmental diseases and neurodegenerative disorders. It discusses the role of iron deficiency in sleep disorders and offers diagnosis and treatment of iron-related CNS diseases. Finally, it relates dysregulated expression of iron-related genes in brain tumors.
    Materialart: Online-Ressource
    Seiten: XX, 280 p. 10 illus., 7 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789811973277
    Serie: Nutritional Neurosciences,
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 83
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    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Cytology. ; Zoology. ; Neurology . ; Neuroscience. ; Cell Biology. ; Zoology. ; Neurology.
    Beschreibung / Inhaltsverzeichnis: The Architecture of the Presynaptic Release Site.-Cytomatrix Proteins in Presynaptic Terminal. - Multiple Modes of Fusion and Retrieval at the Calyx of Held Synapse -- Roles of SNARE Proteins in Synaptic Vesicle Fusion -- Calcium Sensors of Neurotransmitter Release. - Roles and Sources of Calcium in Synaptic Exocytosis -- Regulation of Presynaptic Calcium Channels -- Roles of mUnc13/UNC-13 and mUnc18/UNC-18 in Neurotransmitter Release. - The role of tomosyn in the regulation of neurotransmitter exocytosis. -Roles of complexins in Neurotransmitter Release. -Regulation of Neurotransmitter Release by AIPR-1/AIP and calstabins. - The Role of Potassium Channels in the Regulation of Neurotransmitter Release -- Roles of Neuropeptides in Synaptic Function. - Transsynaptic Regulation of Presynaptic Release Machinery in Central Synapses by Cell Adhesion Molecules. - Lipids and Secretory Vesicle Exocytosis -- Synaptic Vesicle Endocytosis.
    Kurzfassung: Neurons communicate with each other by releasing neurotransmitters. This book provides comprehensive coverage of the molecular mechanisms involved in neurotransmitter release. The topics covered in the book range from the architecture and cytomatrix proteins of presynaptic sites, to the modes of synaptic vesicle exocytosis (full-collapse and kiss-and-run), and from the key molecules mediating synaptic vesicle fusion (SNAREs) to those that closely interact with them (UNC-13/Munc13, UNC-18/Munc18, tomosyn, and complexins). The book also delves into the calcium sensors of synaptic vesicle fusion (synaptotagmins and Doc2s), the sources of calcium that trigger synaptic exocytosis (voltage-gated calcium channels and ryanodine receptors), and the regulation of neurotransmitter release by potassium channels, cell adhesion molecules, lipids, aryl hydrocarbon receptor-interacting protein (AIP), presenilins, and calstabins. To aid in understanding and illustrate key concepts, the book includes sufficient background information and a wealth of illustrations and diagrams. The new edition includes major updates to previous chapters, as well as several new chapters that reflect the recent advances in the field. Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release, 2nd edition, is a valuable learning resource for neuroscience students and a solid reference for neuroscientists.
    Materialart: Online-Ressource
    Seiten: XI, 401 p. 77 illus., 62 illus. in color. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031342295
    Serie: Advances in Neurobiology, 33
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 84
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    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Bioinformatics. ; Medical informatics. ; Quantitative research. ; Biomedical Research. ; Bioinformatics. ; Health Informatics. ; Data Analysis and Big Data.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction to multi-omics -- Part 1. Omics integration techniques -- Chapter 2. Biomedical applications: the need for multi-omics -- Chapter 3. Omics technologies and big data -- Chapter 4. Multi-omics data mining techniques: algorithms and software -- Part 2. Applications of multi-omics analyses -- Chapter 5. Multi-omics data analysis for cancer research: colorectal cancer, liver cancer and lung cancer -- Chapter 6. Multi-omics data analysis for inflammation disease research: correlation analysis, causal analysis and network analysis -- Chapter 7. Microbiome data analysis and interpretation: correlation inferences and dynamic pattern discovery -- Chapter 8. Current progress of bioinformatics for human health.
    Kurzfassung: This book features multi-omics big-data integration and data-mining techniques. In the omics age, paramount of multi-omics data from various sources is the new challenge we are facing, but it also provides clues for several biomedical or clinical applications. This book focuses on data integration and data mining methods for multi-omics research, which explains in detail and with supportive examples the “What”, “Why” and “How” of the topic. The contents are organized into eight chapters, out of which one is for the introduction, followed by four chapters dedicated for omics integration techniques focusing on several omics data resources and data-mining methods, and three chapters dedicated for applications of multi-omics analyses with application being demonstrated by several data mining methods. This book is an attempt to bridge the gap between the biomedical multi-omics big data and the data-mining techniques for the best practice of contemporary bioinformatics and the in-depth insights for the biomedical questions. It would be of interests for the researchers and practitioners who want to conduct the multi-omics studies in cancer, inflammation disease, and microbiome researches.
    Materialart: Online-Ressource
    Seiten: XI, 167 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789811982101
    Serie: Translational Bioinformatics, 19
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 85
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    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Bioclimatology. ; Ecology . ; Oceanography. ; Paleontology . ; Freshwater and Marine Ecology. ; Climate Change Ecology. ; Biooceanography. ; Paleontology.
    Beschreibung / Inhaltsverzeichnis: INTRODUCTION: THE REEF PHENOMENON -- INTO THE INTIMACY OF CORALS, BUILDERS OF THE SEA -- 1 TAXONOMIC AFFILIATION -- 1.1 Systematic classification of cnidarians -- 1.2 Scleractinians -- 2 MORPHOLOGY AND ANATOMY -- 2.1 Polyp anatomy -- 2.2 Reproduction -- 2.2.1 Sexual reproduction -- 2.2.2 Asexual reproduction -- 2.3 Anatomy of calcareous skeletons -- 2.4 Coral colonies -- 2.4.1 Corallite arrangement -- 2.4.2 Colony morphology -- 3 SYMBIOSIS -- 4 BIOMINERALIZATION -- 4.1 Calicoderm and biomineralization -- 4.2 Skeletons and biomineralization -- 4.3 Interface between calicoderm and skeleton -- 4.4 Principles of calcification -- 5 NUTRITION -- 5.1 Prey capture -- 5.2 Food -- 5.3 Autotrophy -- THE MODERN TIMES -- 1 BIOZONATION -- 2 REEF MORPHOTYPES -- 2.1 Fringing reefs -- 2.2 Barrier reefs -- 2.3 Atolls -- 2.4 Bank reefs -- 2.5 High carbonate islands -- 3 GEOGRAPHICAL DISTRIBUTION -- 3.1 Ecological control -- 3.2 Tectonic control -- 3.3 Eustatic control -- 3.4 Topographic control -- 4 REEF GROWTH -- 4.1 Vertical growth strategies -- 4.1.1 Controlling factors -- 4.1.2 Give-up growth -- 4.1.3 Keep-up growth -- 4.1.4 Catch-up mode -- 4.2 Lateral growth -- 5 MORPHO-SEDIMENTARY PROCESSES -- 5.1 Bioconstruction -- 5.2 Erosion -- 5.3 Bioaccumulation -- 5.4 Cementation -- 6 INTERNAL STRUCTURE -- 6.1 Nature and distribution of facies -- 6.1.1 Framework facies -- 6.1.2 Detrital facies -- 6.1.3 Facies distribution and hydrodynamics -- 6.2 The different structural models -- 7 A BRIEF HISTORY OF REEF DEVELOPMENT -- 7.1 The climatic context -- 7.2 History of reef development since the last deglaciation -- 7.3 Reef history throughout the Pleistocene -- 8 RECORD OF ENVIRONMENTAL CHANGES -- 8.1 Record at the coral colony scale -- 8.1.1 Temperature -- 8.1.2 Salinometry -- 8.1.3 Rainfall -- 8.1.4 pH measurement -- 8.1.5 Photometry -- 8.1.6 Current measurement -- 8.2 Record at the scale of a reef edifice -- 8.2.1 Reef flats and micro-atolls -- 8.2.2 Arrangement of coral communities -- 8.2.3 Arrangement of reef edifices -- THE LONG MARCH OF CORALS -- 1 THE TIME OF THE ORIGINS -- 1.1 Early Earth and the first traces of life -- 1.2 Evolution of the atmosphere -- 1.3 Geochemical model of the early ocean -- 1.4 Emergence of biomineralization -- 1.5 The early calcifying organisms and cnidarians -- 1.6 The earliest corals -- 1.7 The appearance of scleractinian corals -- 2 THE TIME OF DIVERSIFICATION -- 2.1 Coral-algae symbiosis -- 2.1.1 Acquiring photosymbiosis -- 2.1.2 Evidence of photosymbiosis -- 2.1.3 Symbiosis and coloniality -- 2.2 A brief history of coral and reef building -- 2.2.1 Paleozoic times -- 2.2.2 Mesozoic times -- 2.2.3 Cenozoic times -- THE HIGHS AND LOWS OF THE REEF PHENOMENON -- 1 CAUSES -- 1.1 Causal relationships -- 1.2 Gas emissions and volcanic products -- 1.3 Methane emissions -- 1.4 Thermogenic gases -- 1.5 The fall of celestial bodies -- 1.6 Behaviour of organisms facing environmental disturbances -- 1.7 Disturbances induced by CO2 and ocean acidification -- 1.8 Thermal shocks -- 1.9 Disturbances induced by ocean deoxygenation -- 2 THE MAIN BIOLOGICAL CRISES -- 2.1 The Cambrian crises -- 2.2 The major crisis of the Ordovician end -- 2.3 The minor crises of the Silurian -- 2.4 The successive crises of the Devonian -- 2.5 The Permian crises -- 2.6 The Triassic crises -- 2.7 The lower Jurassic crisis -- 2.8 The Jurassic–Cretaceous transition (J–K) -- 2.9 The Cretaceous–Paleogene crisis -- 2.10 The Paleocene–Eocene crisis -- 2.11 The Eocene–Oligocene transition -- 2.12 The Oligocene end to the Plio-Quaternary -- 3 THE RESPONSE OF CORALS AND REEFS TO CRISES: FROM EXTINCTION TO RECOVERY -- 3.1 At the Ordovician end -- 3.2 During the Silurian -- 3.3 During the Devonian -- 3.4 At the Permian -- 3.5 At the Permian–Triassic boundary -- 3.6 From the middle to the end of the Triassic -- 3.7 During the Jurassic -- 3.8 From the upper Jurassic to the lower Cretaceous -- 3.9 At the Cretaceous–Paleogene (K–Pg) transition -- 3.10 From the Paleocene to the Eocene -- 3.11 From the Oligocene to the Miocene -- 3.12 During the Plio-Quaternary -- 4 CONCLUSIONS -- CORAL REEFS IN THE FACE OF THEIR FATE -- 1 DISRUPTIVE AGENTS IN ACTION -- 1.1 Carbon dioxide and rising surface water temperatures -- 1.2 Carbon dioxide and its effects on the carbonate cycle -- 1.3 Carbon dioxide and ocean acidification -- 1.4 The other disruptive agents -- 2 THE RESPONSE OF CORALS AND CORAL REEFS -- 2.1 Temperature rise of surface waters -- 2.2 To acidification -- 2.3 To other disruptive agents -- 3 THE EVOLUTION OF CORAL ISLETS -- 3.1 The modes of low-lying island formation -- 3.2 Future evolution of low-lying islands: maintenance, reduction, or destruction? -- CONCLUSIONS -- BIBLIOGRAPHY -- INDICE.
    Kurzfassung: The health status and future of tropical coral reefs, as tourist destinations, are regularly subjected to media coverage. Many documentaries recognize the natural beauty and biological richness of the Australian Great Barrier Reef and French Polynesian lagoons, but point to the equally significant risk that would result from current global warming and human-made hazards. The future of coral reefs is usually a matter of death foretold, real or purely imaginary. In this context, it has become necessary to differentiate between what is falling within reality of scientific facts or fantasy. To this end, the present general review, in the expert translation of Charlotte Fontan aims at: (1) defining the conditions and life requirements of reefbuilding corals; (2) the history of corals along with that of a number of associated, skeletal organisms involved in reef building since the very beginning, i.e. the last 540 million years, including the ups and downs they have experienced; (3) giving special reference to the development patterns of recent and modern reefs; (4) projecting corals and reefs into a still unknown future. Understanding how corals and reefs have originated, how they have been able to face the major biological crises which have punctuated the Earth’s history, how they have survived is a prerequisite to better gain a significant picture of their future.
    Materialart: Online-Ressource
    Seiten: IX, 166 p. 120 illus., 117 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031168871
    Serie: Coral Reefs of the World, 16
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 86
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    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Clinical medicine Research. ; Medical sciences. ; Drug development. ; Bioethics. ; Medical Ethics. ; Biomedical Research. ; Clinical Research. ; Preclinical Research. ; Bioethics. ; Medical Ethics.
    Beschreibung / Inhaltsverzeichnis: Chap 1. Research Environment -- Chap 2. Training, Supervision and Mentoring -- Chap 3. Research Procedures -- Chap 4. Safeguards -- Chap 5. Data Practices and Management -- Chap 6. Collaborative Working -- Chap 7. Publication and Dissemination -- Chap 8. Reviewing, Evaluating and Editing -- Chap 9. How to deal with allegations of misconduct.
    Kurzfassung: This Open Access book is a guide to good, responsible research at each step of the process of research discovery, so that a researcher at the beginning of a scientific career has a clear pathway to doing good research and producing reliable results. The textbook will give context to the practices described in the European Code of Conduct for Research Integrity, guided by the fundamental principles or research integrity – reliability, honesty, respect, and accountability. The chapters in the book follow the good practices outlined in the Code, give practical advice and address basic principles. In this way, the book is applicable to different research fields. It directs readers to various sources for further and updated information, particularly drawing from the resources available at The Embassy of Good Science, the European platform for research integrity and ethics.
    Materialart: Online-Ressource
    Seiten: XIII, 135 p. 13 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031224126
    Serie: Collaborative Bioethics, 1
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 87
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    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Cytology. ; Ecology . ; Neural circuitry. ; Neuroscience. ; Cell Biology. ; Ecology. ; Neural Circuits.
    Beschreibung / Inhaltsverzeichnis: 1. Introduction -- 2. Diversity and evolution of jellyfish visual systems, Mollusks -- 3. Scallops distributed eyes -- 4. Chiton dispersed visual systems, Annelids -- 5. Errant polychaetes Arthropods -- 6. Spider eyes -- 7. Myriapod eyes -- 8. Insect ocelli -- 9. Batflies, copepods or larval stomatopods -- 10 -- Hyperiid amphipods, Echinoderms -- 11. Brittle star vision -- 12. Starfish vision.
    Kurzfassung: This volume explores the diversity of distributed eyes and other unusual visual systems in nature. It compares the unique themes of optics, neural processing, and behavioral control that emerge from these visual systems with more-canonical eyes. This volume attempts to answer a number of questions about distributed visual systems. What are distributed visual systems good for, how do they function, and why have they arisen independently in so many phyla? Why are eye designs and visual system arrangements much more diverse in invertebrates? Each chapter includes an overview of the visual systems that exist in their group of animals, relates vision to ecology, and takes a comparative approach. .
    Materialart: Online-Ressource
    Seiten: VII, 320 p. 70 illus., 55 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031232169
    Serie: Springer Series in Vision Research,
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 88
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Invertebrates. ; Ecology . ; Oceanography. ; Freshwater and Marine Ecology. ; Biodiversity. ; Invertebrate Zoology. ; Biooceanography.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. The Shrimps: An Overview -- Chapter 2. Structure and Function -- Chapter 3. The Families of Decapod Shrimps -- Chapter 4. Shrimp Hygiene: Antifouling Adaptations -- Chapter 5. Coloration, Color Change and Camouflage -- Chapter 6. Reproduction -- Chapter 7. Sexual Systems -- Chapter 8. Mating Systems -- Chapter 9. Life Histories -- Chapter 10. Symbioses -- Chapter 11. Fisheries and Aquaculture -- Chapter 12. Evolutionary History and Relationships of Shrimps.
    Kurzfassung: This book explores the biology of decapod shrimps, a group of animals known to most people as a nutritious and tasty food item. Shrimps are amazingly diverse in size, shape, coloration, behavior and natural history. Shrimp fisheries and aquaculture are a vital part of the USA and world economies. These crustaceans are key ecological and food-web components of marine and freshwater habitats. The book synthesizes information on the taxonomic and ecological diversity of shrimps, the structure and function of shrimp anatomy, antifouling adaptations, coloration and camouflage, reproductive biology, sexual systems, mating systems and behavior, life history strategies, symbioses between shrimps and other organisms, shrimp fisheries and aquaculture, as well as the evolution and phylogeny of shrimps. All chapters are written within an adaptational and evolutionary perspective. Important questions about shrimp biology are asked, and hypotheses for testing in future research are proposed. The book is spiced up with personal anecdotes and observations from the author’s research experiences. This book is intended as a comprehensive reference, a “go to” book about the biology of shrimps. The text is scientifically rigorous but written in a style intended for a varied readership. Thus, the book is a valuable resource for budding or working research scientists such as zoologists, aquatic biologists, fisheries and aquaculture professionals, as well as amateur naturalists, aquarium hobbyists and interested laypersons. As the saying goes, “a picture is worth a thousand words,” so that the book is amply illustrated with figures and diagrams.The numerous color plates, composed of photos contributed by expert colleagues, make the world of shrimps come alive.
    Materialart: Online-Ressource
    Seiten: XIX, 720 p. 239 illus., 40 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031209666
    Serie: Fish & Fisheries Series, 42
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 89
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Environmental chemistry. ; Pollution. ; Toxicology. ; Freshwater and Marine Ecology. ; Environmental Chemistry. ; Pollution. ; Toxicology.
    Beschreibung / Inhaltsverzeichnis: Part I. Introduction -- An Introduction to Reservoir Ecotoxicology -- Part II. Environmental Characteristics in Reservoir Ecosystems -- Characterization of Reservoir Ecosystem -- Main Sources and Distribution of Pollutants in the Reservoir -- Migration and Transformation of Pollutants in the Reservoir -- Harmful Algal Bloom in the Reservoir -- Microplastics Pollution in the Reservoir: Occurrence, Extraction, and Characterization -- Distribution of Microorganisms in the Reservoir -- Part III. Study Methods of Ecotoxicology in the Reservoir -- Ecotoxicity Test Methods of Primary Producers in the Reservoir -- Ecotoxicology Methods of Reservoir Water Using Invertebrates -- Ecotoxicology Methods of Reservoir Water Using Fish -- Ecotoxicology Methodology of Sediment Toxicity in the Reservoir -- Mesocosm Study in the Reservoir Ecosystem -- Part IV. Ecotoxicological Effects and Mechanism of Pollutants in the Reservoir -- Molecular Toxicity Mechanism of Heavy Metals in the Reservoir -- Molecular Toxicity Mechanism of Persistent Organic Pollutants (Pops) in the Reservoir -- Molecular Toxicity Mechanism of Microplastics in the Reservoir -- Molecular Toxicity Mechanism of Plasticizers in the Reservoir -- Molecular Toxicity Mechanism of PPCPs in the Reservoir -- Adverse Outcome Pathways (AOPs) of Pollutants in the Reservoir -- Invasive Alien Species Problem in the Reservoir -- Part V. Conclusions -- Final Thoughts and Concluding Remarks.
    Kurzfassung: Reservoir construction is the key strategy for water resource management. In recent years, the migration of pollutants and their transformation into the reservoir ecosystem has become a global problem. Intensified anthropogenic activities and unsustainable practices have amplified the pollutant levels in the reservoir. Therefore, this book intends to highlight environmental characteristics of the reservoir, study methods of ecotoxicology, and mechanistic toxicogenetic pathways of pollutants in the reservoir. Adverse outcome pathway (AOPs) model is used to elucidate toxicological effects of reservoir pollutants. Moreover, ecological and human health risks of the Three Gorges Reservoir (TGR), the largest power generation reservoir on earth, and its pollution status are also discussed.
    Materialart: Online-Ressource
    Seiten: XXXI, 234 p. 31 illus., 28 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031263446
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 90
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    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Neuroscience.
    Beschreibung / Inhaltsverzeichnis: Editorial -- Dystonia in childhood - how insights from paediatric research enrich the network theory of dystonia -- Focal Dystonia and the Stress-Network -- Limbic influences in Musicians dystonia -- Network perspective on task-specific dystonia -- Electromyography as a method for distinguising dystonia-like behavior in mice -- Deep brain stimulation of the interposed cerebellar nuclei in a mouse model of dystonia -- Applications of Transcranial Magnetic Stimulation for understanding and treating dystonia -- Brain connectivity in dystonia: evidence from Magnetoencephalography -- Dysfunctional networks in functional dystonia -- Collicular-pulvinar-amygdala axis and adult-onset idiopathic focal dystonia syndrome -- Neuromodulation in dystonia -- Electrophysiological properties of pallidal cells in cervical dystonia patients undergoing unilateral DBS -- Clinical implications of dystonia as a neural network disorder.
    Kurzfassung: A recently proposed novel scheme of dystonia suggests that it is a disorder of neural network. Impairment in any of the “nodes” of the network may result in deficient network activity, causing dystonia. This book aims to present various experimental evidence supporting the network theory of dystonia. Dystonia is the abnormal twisting and turning of the organ and associated involuntary oscillations. Although dystonia is less common than Parkinson’s disease, traumatic brain injury, or stroke, each of these common disorders present with dystonia. Information regarding the brain regions that may be involved in dystonia is surprisingly limited and often conflicting. With chapters written by subject matter experts, this is a unique title that focuses on dystonia as a network disorder. This book would be of interest to basic and clinical researchers with an interest in motor systems and movement disorders.
    Materialart: Online-Ressource
    Seiten: XI, 242 p. 37 illus., 31 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031262203
    Serie: Advances in Neurobiology, 31
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 91
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    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Biodiversity. ; Zoology. ; Ecology . ; Oceanography. ; Bioclimatology. ; Environment. ; Freshwater and Marine Ecology. ; Biodiversity. ; Zoology. ; Biooceanography. ; Climate Change Ecology. ; Environmental Sciences.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction: The Relevance of Anthropogenic Factors to Coral Reef Conservation in the Coastal Areas of the East China Sea -- Chapter 2. Transitional Coral Ecosystem of Taiwan in the Era of Changing Climate -- Chapter 3. Dynamics of Coral Reef Communities in the Sekisei Lagoon, Japan, Following the Severe Mass Bleaching Event of 2016 -- Chapter 4. Succession and Emergence of Corals in High-Latitude (Temperate) Areas of Eastern Asia into the Future -- Chapter 5. Succession and Spread of Coral Diseases and Coral-Killing Sponges with Special Reference to Microbes in Southeast Asia and Adjacent Waters -- Chapter 6. Succession of Ocean Acidification and its Effects on Reef-Building Corals -- Chapter 7. Anthropogenic Stresses in Coral Reefs and Adjacent Ecosystems of the East China Sea -- Chapter 8. Development of a Compact Experimental System for Ecotoxicological Experiments on Acropora spp. -- Chapter 9. Effects of Anthropogenic Chemicals on Hermatypic Corals with Special Reference to Gene Expression -- Chapter 10. Perspective for the Conservation of Coral Reefs in the East China Sea.
    Kurzfassung: Coral reefs, which are one of the most productive and biodiverse ecosystems on Earth, serve various important roles, such as providing shelter and spawning grounds to a wide range of marine animals. However, the global decline of hard corals in tropical and subtropical regions is a growing concern. A recent review of the Intergovernmental Panel on Climate Change (IPCC) indicated that only 10%–30% of coral reefs would survive with an increase of 1.5 °C in global warming temperature. Of coral reefs around the world, the coral reefs in eastern Asia face one of the most industrially developed and high population areas in the world. Thus, coral reefs of eastern Asia have been affected by various anthropogenic factors, such as eutrophication, coastal development, anthropogenic pollutants, ocean acidification, disease, and overfishing. Therefore, urgent research is required to determine the levels at which different factors will affect coral health. Besides, we propose a perspective on coral reef (especially those in eastern Asia) conservation under climate change and various anthropogenic activities.
    Materialart: Online-Ressource
    Seiten: VII, 180 p. 87 illus., 82 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031275609
    Serie: Coral Reefs of the World, 17
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 92
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    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Neurosciences. ; Neurology . ; Nervous system Diseases. ; Cognitive neuroscience. ; Neurophysiology. ; Learning Physiological aspects. ; Memory Physiological aspects. ; Neuroscience. ; Neurology. ; Neurological Disorders. ; Cognitive Neuroscience. ; Neurophysiology. ; Learning and Memory.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction -- Chapter 2. The Psychiatrist and Pathologist Aloysius Alzheimer and His Seminal Findings -- Chapter 3. Alzheimer’s Disease Research After 1945: The Recommencement -- Chapter 4. Alzheimer’s Research Goes Deeper – Ultrastructural Electron Microscopy Studies -- Chapter 5. Focus on Neurochemistry Led to the Cholinergic Hypothesis of Alzheimer’s Disease -- Chapter 6. The Glutamatergic-Hypothesis of Alzheimer’s Disease -- Chapter 7. Biochemistry and Genetics Points Out a Prime Suspect for Causing Alzheimer’s Disease -- Chapter 8. Getting to the Bottom of It: Amyloid Beta Peptide Is Derived from a Larger Precursor -- Chapter 9. Step by Step Towards an Amyloid Beta Peptide-Based Hypothesis of Alzheimer’s Disease -- Chapter 10. Concerns about the Amyloid Cascade Hypothesis and Reappraisals -- Chapter 11. Ignorance or Conspiracy? Or Just an Amyloid Firewall that Blocks Alternative Ideas? -- Chapter 12. In the Slip Stream of Amyloid: The Tau and Tangle Hypothesis -- Chapter 13. Focus on Tauopathies and Beyond -- Chapter 14. Alzheimer’s Research Gains Momentum and Spreads Out -- Chapter 15. The Amyloid Cascade Hypothesis Has to Deliver, Finally -- Chapter 16. Beyond APP, PSEN1, PSEN2, and APOE: What Else Does the Genome Tell Us? Chapter 17. Alternative Hypotheses and Observations that were Somehow Lost on the Way -- Chapter 18. Is the Persistence of the Amyloid Cascade Hypothesis a Result of Constant Confirmation Bias? -- Chapter 19. Driving Forces of Alzheimer’s Research Directions -- Chapter 20. Thirty Years after the Launch of the Amyloid Cascade Hypothesis: Is There a Shift of Gears at Last? -- Chapter 21. "If You Change the Way You Look at Things, Things You Look at Change".
    Kurzfassung: This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer’s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer’s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer’s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer’s research community is finally ready to shed its ‘amyloid-straitjacket’ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer’s Disease research and provide a new and broader perspective on this age-dependent brain disease.
    Materialart: Online-Ressource
    Seiten: XXV, 652 p. 116 illus., 107 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031315701
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 93
    Schlagwort(e): Neurosciences. ; Immunology. ; Ophthalmology. ; Neuroscience. ; Immunology. ; Ophthalmology.
    Beschreibung / Inhaltsverzeichnis: High Resolution Imaging Mass Spectrometry of Human Donor Eye: Photoreceptor Cells and Basal Laminar Deposits of Age-related Macular Degeneration -- The non-canonical role of Complement Factor H in Retinal Pigment Epithelium (RPE) cells and implications for Age-related Macular Degeneration -- Macular Pigment Carotenoids and Bisretinoid A2E -- Disturbed matrix metalloproteinases activity in age-related macular degeneraton -- Current views on Chr10q26 contribuiton to age-related macular degeneration -- Untargeted lipidomic profiling of aged human retina with and without age-related macular degeneration (AMD) -- Decoding Race and Age-Relation Macular Degeneration: GPR 143 Activity is the Key -- Peroxisome proliferator-activated receptor gamma coactivator 1 alpha ( PGC-1x): a transcriptional regulator at the interface of aging and age-related macular degeneration? -- Regulation of ABCA1 by miR-33 and miR-34a in the aging eye -- The role of gene expression regulation on genetic risk of Age-related Macular Degeneration -- Elastin layer in Bruch's membrane as a target for immunizatio or tolerization to modulate patthology in the mouse model of somke-induced ocular injury -- Repuprosing drugs for treatment of age-relation macular degeneration -- Extracellular Vesicle RNA Contents as Biomarkers for Ocular Diseases -- Proteomics of retinal extracellular vesicles: a reviw inot an unexplored mechanism in retinal health and AMD pathogenesis -- Prime Editing Strategy to Instally the PRHP2 c.828+1G A mutations -- Analysis of CRB1 Pathogenic Variants Correctable with CRISPR Base and Prime Editing -- Generation of an Avian Myeloblastosis Virus (AMV) Reverse Transcriptase Prime Editor -- Pre-existing neutralizing antibodies against different adeno-associated virus serotypes in humans and large animal models for gene therapy -- Optimization of Capillary-based Western Blotting for MYO7A -- AAV Serotypes and Their Suitability for Retinal Gene Therapy -- Gene Augmentation ofautosomal dominant CRX-associated retinopathies -- Txnip gene therapy of retinitis pigmentosa improves cone health Factors affecting readthrough of natural versus premature termination codons -- Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease -- Network biology and medcine to resuce: Applications for retinal disease mechanisms and therapy -- Non-sydromic Retinal Degeneration Caused by Pathogenic Variants in Joubert Syndrome Genes -- Exonic variants that affect splicing- an opportunity for "hidden" mutations causing inherited retinal diseases -- Enhanced S-cone Syndrome, a Mini-Review -- The role of microglia in Inherited Retinal Diseases -- CD68: potential contributor to inflammation and RPE cell dystrophy -- Gene Expression of Clusterin, Tissue Inhibitor of Metalloproteinase-1, and Their receptors in Retinal Pigment Epithelial Cells and Muller Glial Cells is Modulated by Inflammatory Stresses -- Axonal Transport Defects in Retinal Ganglion Cells -- Connexins biology in the pathophysiology of retinal diseases -- Role of Nuclear NAD +in Retinal Homeostasis -- Retinal pigmented epithelium-derived ectopic norrin does not promote intraretinal angiogenesis in transgenic mice -- Caveolin-1 Muller glia exist as heat-resistant,high molecular weight complexes -- Role of VLC-PUFAs in Retinal and Macular Degeneration -- Ocular amyloid , condensates, and aggregates - higher order protein assemblies participate in both retinal degeneration and function -- Photoreceptor ion channels in signaling and disease -- The role of peripherin-2 /ROM1 complexes in photoreceptor outer segment disc morphogenesis -- Human mutations in Arl3, a small GTPase involved inlipidated cargo delibery to the cilia cause retinatl dystropthy -- Genotype-Phenotype Association in ABCA4-Associated Retinopathy -- Retinal pathoconnectomics: A Window into Neurodegeneration -- The role of Ceramide in Inherited Retinal Disease Pathology -- Extracelluar Matix: the Unexplored Aspects of Retinal Pathologies and Regeneration -- Role of TFEB in diseases assocaited with lysosomal dysfunction -- Retinoic acid receptor -related oprhan receptors (RORs) in eye development and disease -- A novel mouse model for Late-Onset Retinal Degeneration (L-ORD) devekios RPE abnormalities due to the loss of C1qtnf5/Ctrp5 -- Comparison of mouse models of autosomal dominant retinitis pigmentosa due to P23H muations of Rhodopsin -- Compensatory Cone-Mediated Mechanisms in Inherited Retinal Degeneration Mouse Models: A Functional and Gene Expression Analsyis -- Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Sress and Promotes ER Protein Degradation in Cyclic Nucleotide-gated Channel Deficiency -- Mouse choroid proteome revisited: foucs on aging -- Morphological and functional comparison of mice models for retinitis pigmentosa -- Current Advancements in Mouse Models of Retinal Disease -- Single-cell Itrnacriptomic Profiling of Muller Glia in the rd10 Retina -- Methods for in vivo characterization of proteostatis in the mouse retina -- Absence or PRCD leads to dysregulation in lipie Homeostatis resulting in disorganizationof photorecptor outer segment structure -- Expansion Microscopy of Mouse Photoreceptro Cilia -- Rod photorecptor specific ablation of Metformin target, AMPK, in preclinical model of autosomal recessvie retinitis pigmentosa -- TLR2 is highly overexpressed in retinal myeloid cells in the rd10 mouse model of retinitis pigmentosa -- Environmental light has an essentail effrect on the diseasae expression in a dominant RPE65 mutation -- Microglia Preserve Visual Function in A Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant -- Measuring the release of lactate from wild-type and rd1 mouse retina -- Aerobic glycolysis in photorecptors supports energy demand in the absence of mitochondrial coupling -- Redox Status in Retinitis Pigmentosa -- Perspectives on retinal dolichol metabolism and visual deficits in dolichol metalbolism-associated inherited disorders -- Retinal metabolic profile on IMPG2 deficiency mice with subretinal lesions -- Glutathione-coating of liposomes enhances the delivery of hydrophillic cargo to the inner nuclear layer in retinal cultures -- Modification of Mueller glial cell fate and proliferation with the use of small molecules -- A potential neuroprotective role for pyruvate kinase 2 in retinal degeneration -- Critical role of VEGF as a direct regulator of photorecptor function -- Lysine Ubiquitylation Drives Rhodopsin Protein Turnover -- In-silico prediction of MYO!C Rhodopsin Interactions and its Significance in Protein Localization and Visual Function -- A ciliary branched actin netowrk drives photoreceptor disc morphogenesis -- Revisiting the daily timing of POS phagocytosis -- Inhibition of Bacterial Peoptidoglycan Cytopahty by Retina Pigment Epithelial PGRP2 Amidase -- Understanding ischemic retinopathies: the role of Succinate and its recpto^T mutation -- Inducing neural regeneratio nfrom glia using proneural bHLH transcription factors.
    Kurzfassung: This book contains the proceedings of the XIX International Symposium on Retinal Degeneration. A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. These retinal degeneration symposia are known by most as the “best” and “most important” meetings in the field. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. We anticipate that the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.
    Materialart: Online-Ressource
    Seiten: XIX, 588 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031276811
    Serie: Advances in Experimental Medicine and Biology, 1415
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Neurosciences. ; Neurology . ; Cognitive psychology. ; Neuroscience. ; Neurology. ; Cognitive Psychology.
    Beschreibung / Inhaltsverzeichnis: The world of Brain: from Aging Brain, Diseased Brain to Social Brain -- Cognitive Aging:How the Brain Ages -- Cognitive Decline Associated with Aging -- The Overview of Cognitive Aging Model -- The Emotional and Affective Disorders in Cognitive Aging -- The Mechanism of Socioeconomic Status and Stress Effects on Cognition -- The Aging Patterns of Brain Structure, Function and Energy Metabolism -- Characteristics of Brain Network during Cognitive Aging -- Biomolecular Markers of Brain Aging -- Neurobiological Mechanisms of Cognitive Decline Caused by Brain Aging -- The Early Stage of Abnormal Aging: Cognitive Impairment -- The Terminal Stage of Abnormal Aging: Dementia -- The Effect of Cognitive Rehabilitation Training and Its Neuroimaging and Physiology Evidence -- Lifestyle Regulation and Its Evidence: Changes brought from Adjusting Correlative Factors of Cognitive Aging -- The Effect of Traditional Chinese Medicine on Delaying Age-related Cognitive Decline and Its Evidence.
    Kurzfassung: This book reviews the research trends of cognitive aging and brain health from full-scale. It not only contains cognitive aging’s neurophysiological mechanism, clinical research and intervention measures, but also covers cognitive aging’s social psychological mechanism, such as the relation between old people’s motion, socioeconomic status and the cognitive aging. Through decades of research and practice, the views towards the cognitive aging process havebeen transferred from coping with cognitive decline to promoting cognitive ability. This book provides with the latest research findings and in-depth opinions of the cognitive aging and brain health, assisting researchers to grasp the theories, practice and trends of this field, and guide health-care workers to carry out the treatment and nursing for the aged.
    Materialart: Online-Ressource
    Seiten: VIII, 194 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819916276
    Serie: Advances in Experimental Medicine and Biology, 1419
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
    Schlagwort(e): Medicine Research. ; Biology Research. ; Biomedical Research.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Introduction and History of Meningiomas -- Chapter 2. Clinical Presentation and Prognosis -- Chapter 3. Imaging Characteristics of Meningiomas -- Chapter 4. Histopathology of Meningiomas -- Chapter 5. Skull Base Meningiomas -- Chapter 6. Spinal Meningiomas -- Chapter 7. Surgical Therapies -- Chapter 8. Radiation Therapies -- Chapter 9. Illustrative Cases -- Chapter 10. Advances in CNS Tumor Classification -- Chapter 11. Genomic Landscape -- Chapter 12. Radiation-Induced Meningiomas -- Chapter 13. Meningioma Predisposing Syndromes -- Chapter 14. Epigentic Landscape -- Chapter 15. Immune Profile -- Chapter 16. PDX Models/Mouse Models/Cell Lines -- Chapter 17. Novel Medical Therapies -- Chapter 18. Quality of Life in Menigioma Patients -- Chapter 19. Illustrative Cases: Revisited with Adjuvant Molecular Data -- Chapter 20. Future Directions in Management.
    Kurzfassung: "Meningiomas are tumors that originate from the arachnoidal cap cells of the leptomeninges. With an incidence rate of 8.36 per 100, 000 population, they are the most common primary central nervous system (CNS) tumors, accounting for a third of all cases. The World Health Organization (WHO) classification has traditionally categorized meningiomas into 15 different histopathological subtypes and three clinical grades. Tumors are classified as WHO grades 1, 2 or 3 based largely on histopathological features such as mitotic activity, presence of brain invasion, and other atypical features. However, there is increasing recognition of the limitations of histopathology including but not limited to: confounding factors such as sampling bias in a heterogeneous tumor, and technical factors related to the experience of the grading pathologist. Even with careful histologic grading, there remains significant variability in recurrence rates within each tumor grade. As more studies have uncovered the molecular features of meningiomas, novel biological alterations have helped refine classification schemes that more accurately reflect patient outcomes. This book reviews the current state of knowledge on the genomic and epigenomic landscape of meningiomas in order to identify the roles of genomic aberrations on diagnosis, prognosis, and treatment of meningiomas in addition to mainstays of surgical management, radiation therapy, and potential novel chemotherapies. Written by a team of world-renowned experts in neurosurgery, neuropathology, radiology, and radiation-oncology, this book is the definitive resource on meningioma management and investigation for both clinicians and scientists alike.".
    Materialart: Online-Ressource
    Seiten: XVII, 255 p. 55 illus., 33 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031297502
    Serie: Advances in Experimental Medicine and Biology, 1416
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Biomedical engineering. ; Biophysics. ; Medical physics. ; Signal processing. ; Bioinformatics. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Biophysics. ; Medical Physics. ; Signal, Speech and Image Processing . ; Bioinformatics.
    Beschreibung / Inhaltsverzeichnis: Preface -- Part I: Backscatter Coefficient methods -- Chapter 1. Quantitative Ultrasound: an Emerging Technology for Detecting, Diagnosing, Imaging, Evaluating, and Monitoring Disease (Ernie Feleppa) -- Chapter 2. Quantitative Ultrasound: Scattering theory (Michael Oelze) -- Chapter 3. Quantitative Ultrasound: Experimental implementation (Michael Oelze) -- Chapter 4. Extracting Quantitative Ultrasonic Parameters from the Backscatter Coefficient (Aiguo Han) -- Part II: Attenuation Estimation Methods -- Chapter 5. Attenuation Compensation and Estimation (Timothy Bigelow and Yassin Labyed) -- Chapter 6. Recent advances in attenuation estimation (Ivan Rosado Mendez) -- Part III: Envelope Statistics Methods -- Chapter 7. Review of envelope statistics models for quantitative ultrasound imaging and tissue characterization (Francois Destrempes and Guy Cloutier) -- Chapter 8. Information entropy and its applications (Po-Hsaing Tsui) -- Part IV: Ultrasound Computed Tomography -- Chapter 9. Ultrasound Tomography (Nicole Ruiter, Torsten Hopp, Michael Zapf and Hartmut Gemmek) -- Chapter 10. Full Wave Inversion and Inverse Scattering in Ultrasound Tomography/Volography (James Wiskin) -- Chapter 11. Clinical Importance of 3D Volography in Breast Imaging (John Klock) -- Part V: Acoustic microcopy -- Chapter 12. Acoustic Microscopy (Yoshifumi Saijo) -- Chapter 13. Advanced Topics in Quantitative Acoustic Microscopy (Cameron Hoerig and Jonathan Mamou) -- Part VI: Phantoms for Quantitative Ultrasound -- Chapter 14. Phantoms for Quantitative Ultrasound (Tim Stiles) -- Index.
    Kurzfassung: Quantitative ultrasound (QUS) continues to mature as a research field and is primed to make a swift transition to routine preclinical and clinical applications. This book will serve two main purposes: Advanced education in QUS by providing a complete and thorough review of all theoretical, physical, and engineering aspects of QUS. Review of recent development of QUS by lead contributors in the research field. This 2nd edition will focus on 6 modern research topics related to quantitative ultrasound of soft tissues: Spectral-based methods for tissue characterization, tissue typing, cancer detection, etc. Attenuation estimation for tissue characterization and improving spectral based methods Envelope statistics analysis as a means of quantifying and imaging tissue properties. Ultrasound computed tomography for preclinical and clinical imaging. Scanning acoustic microscopy for forming images of mechanical properties of soft tissues with micron resolution. Phantoms for quantitative ultrasound.
    Materialart: Online-Ressource
    Seiten: X, 307 p. 1 illus. , online resource.
    Ausgabe: 2nd ed. 2023.
    ISBN: 9783031219870
    Serie: Advances in Experimental Medicine and Biology, 1403
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
    Online-Ressource
    Online-Ressource
    Singapore :Springer Nature Singapore :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Cytology. ; Biological transport. ; Cell membranes. ; Biomedical Research. ; Translational Research. ; Cell Biology. ; Membrane Trafficking.
    Beschreibung / Inhaltsverzeichnis: Section I. Extraction Methods -- Chapter 1. Updated Methods of Extracellular Vesicles Isolation -- Section II. Extracellular Vesicles in Cardiovascular Disease -- Chapter 2. Extracellular Vesicles and Pathological Cardiac Hypertrophy -- Chapter 3. Extracellular Vesicles and Cardiac Aging -- Chapter 4. Extracellular Vesicles and Ischemic Cardiovascular Diseases -- Chapter 5. Extracellular Vesicles and Hypertension -- Chapter 6. Extracellular Vesicles and Coronary Artery Disease -- Chapter 7. Extracellular Vesicles and Vascular Inflammation -- Chapter 8. Extracellular Vesicles and Muscle Atrophy Treatment -- Section III. Extracellular Vesicles in Metabolic Diseases -- Chapter 9. Extracellular Vesicles and Fatty Liver -- Chapter 10. Extracellular Vesicles and Obesity -- Chapter 11. Extracellular Vesicles in Bone Remodeling and Osteoporosis -- Section IV. Therapeutic Implications -- Chapter 12. Diagnosis of Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Chapter 13. Therapeutics of Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Chapter 14. Gene Therapy of Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Section V. Future Prospects -- Chapter 15. Prospective Advances of Extracellular Vesicles Investigation in Cardiovascular and Metabolic Research -- Chapter 16. Effects of Exercise on Circulating Extracellular Vesicles in Cardiovascular and Metabolic Diseases -- Chapter 17. Extracellular Vesicle Release from Platelets and their Contributions to Thrombosis.
    Kurzfassung: This book provides the latest research progress on Extracellular vesicles (EVs) in cardiovascular and metabolic diseases. EVs are small bilayer lipid membrane vesicles released by cells and function for intercellular communication. Increasing evidence has shown that EVs play crucial roles in cardiovascular and metabolic diseases, which seriously threaten human health worldwide. The book contains four sections: 1) Extraction Methods; 2) EVs in Cardiovascular Diseases; 3) EVs in Metabolic Diseases; and 4) Therapeutic Implications. This book is useful for biologists, cardiologists, cardiovascular surgeons, endocrinologists, internists, nurses, undergraduate and graduate students in medicine and cell biology, and others interested in cardiovascular and metabolic medicine.
    Materialart: Online-Ressource
    Seiten: VIII, 275 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9789819914432
    Serie: Advances in Experimental Medicine and Biology, 1418
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
    Schlagwort(e): Neurosciences. ; Neurochemistry. ; Medicine Research. ; Biology Research. ; Regenerative medicine. ; Neuroscience. ; Neurochemistry. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering.
    Beschreibung / Inhaltsverzeichnis: The Purinergic Signaling: Overview -- Adenosine A2A Receptor-containing Heteromers and Neuroprotection -- Purinergic Signaling in Brain Physiology -- Neurotrophic Actions of Adenosine and Guanosine: Implications for Neural Development and Regeneration? -- Purinergic Signaling in Neurogenesis and Neural Fate Determination: Current Knowledge and Future Challenges -- Purinergic Signaling in Autism Spectrum Disorder -- Purinergic Signaling in Depression -- Roles of Purinergic Receptors in Alzheimer's Disease -- Purinergic Signaling in Basal Ganglia Diseases: Parkinson's Disease -- A Step in the ALS Direction: Lessons from the Purinome -- Purinergic P2 Receptors in Epilepsy -- Purinergic Signaling in Neuroinflammation -- Purinergic Signaling in Brain Tumors -- Development of Purinergic Receptor Agonists and Antagonists -- Acupuncture for Counteracting P2X4 and P2X7 Receptor Involvement in Neuroinflammation.
    Kurzfassung: This volume explores the quickly evolving field of Purinergic signaling, and examines how receptors for ATP and other nucleotides, and receptors for adenosine, act in neuronal transmission, control of synaptic activity, proliferation, differentiation and cell death regulation in the CNS. This book focuses on the participation of purinergic receptors and ectonucleotidases, degrading ATP into adenosine, in embryonic and adult neurogenesis in vitro and in vivo as well as in synaptic transmission and pathophysiology. Further, the chapters discuss varying brain diseases, including Parkinson’s, and Alzheimer’s disease, autism, mood disorders and epilepsy, as well as brain tumors, in the context of purinergic signaling and its clinical aspects. The development of purinergic receptor agonists is also an important issue of this book. This book provides a critical review of the current state of science and will be useful for both scientists and students who are or would like to get involved in this area. Furthermore, this book addresses neuroscientists, physician and professionals from the industry, who would like to update themselves in this exciting and rapidly growing field of neuroscience.
    Materialart: Online-Ressource
    Seiten: X, 376 p. 34 illus., 3 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031269455
    DDC: 612.8
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    Online-Ressource
    Online-Ressource
    Cham :Springer Nature Switzerland :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Medical education. ; Anatomy. ; Education Data processing. ; Biomedical Research. ; Medical Education. ; Anatomy. ; Computers and Education.
    Beschreibung / Inhaltsverzeichnis: Part I. History of Medical Illustration, Graphic Medicine, Humanizing Healthcare and Equitable Visualizations -- Chapter 1. Drawn Together: Merging the Worlds of Health and Comics Through Graphic Medicine -- Chapter 2. Medical Graphics and Graphic Medicine -- Chapter 3. Decolonising Visual Narratives in Global Health: The Case for Equitable and Ethical Imagery Use -- Chapter 4. Medical Illustration in Anatomy -- Chapter 5. Valuing Creativity in Biomedical Science Education: A Reflective Narrative -- Chapter 6. Biomedical Visualization in Embryology Education: A Scoping Review -- Chapter 7. A Framework for the Design, Production, and Evaluation of Scientific Visualizations -- Part II. Anatomical and Cell Biology Education -- Chapter 8. Palpation: The Art of Felt Anatomy -- Chapter 9. Teaching Histology with Analogies -- Chapter 10. Using the Hands for Learning Anatomy -- Chapter 11. Corporeal Pedagogy: Visualizing Anatomy Through Art, Archaeology and Medicine.
    Kurzfassung: This book contains subjects by authors with a fresh, exciting and extensive focus within the medical humanities, offering the reader chapters which include the history of medical illustration, Graphic Medicine as a vehicle for the expression of humanistic dimensions of healthcare, equitable and ethical medical illustrations, as well as novel, art-based approaches in anatomical education. Authors consider the role of visual narratives in medical and scientific illustration, the unique affordances of the comics medium, the history of comics as a form of medical and scientific visualization, and the role of comics as didactic tools and as vehicles for the expression of the humanistic dimensions of healthcare. A chapter considers ethical and equitable implications in global healthcare practice, and highlights the work currently being undertaken to address inappropriate and problematic depictions of people in global health visualizations. This will inform the reader of emerging and current thinking about visual communication and the use of images in the public domain, as well as in the healthcare and education sectors. Novel approaches in anatomical education include the benefits of three-dimensional anatomy models made of felt, visual analogies as a method to enhance students’ learning of histology, the use of the hands for learning anatomy, and visualizing anatomy through art, archaeology and medicine. This book will appeal to readers who have an interest in the medical humanities, Graphic Medicine, and ethical medical and anatomical illustrations. These include academic and non-academic readers, medical students, medical educators, clinicians, health-care workers, as well as policy makers.
    Materialart: Online-Ressource
    Seiten: XIV, 249 p. 88 illus., 81 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031390357
    Serie: Biomedical Visualization, 3
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Freshwater ecology. ; Marine ecology. ; Animal culture. ; Vertebrates. ; Sexual selection. ; Freshwater and Marine Ecology. ; Animal Science. ; Vertebrate Zoology. ; Sexual Selection.
    Beschreibung / Inhaltsverzeichnis: Chapter 1. Sex and Behavior -- Chapter 2. Genetic Tools to Investigate the Consequences of Sex -- Chapter 3. Skulls, Teeth, and Sex -- Chapter 4. Cetacean Evolution: Copulatory and Birthing Consequences of Pelvic and Hindlimb Reduction -- Chapter 5. Sexual Anatomy of Female Cetaceans: Art and Science Contribute Insights into Functionality -- Chapter 6. Interspecific Comparison of Reproductive Strategies -- Chapter 7. Non-Conceptive Sexual Behavior in Cetaceans: Comparison of Form and Function -- Chapter 8. Play, Sexual Display, or Just Boredom Relief? -- Chapter 9. Sexual Behaviors of Odontocetes in Managed Care -- Chapter 10. Infanticide and Sexual Conflict in Cetaceans -- Chapter 11. Drone Perspectives on Cetacean Mating and Sex -- Chapter 12. Inter- and Intrapopulation Variation in Bottlenose Dolphin Mating Strategies -- Chapter 13. Sex and Sexual Strategies in Deep-Diving Risso's Dolphins -- Chapter 14. Sociosexual Behavior of Nocturnally Foraging Dusky and Spinner Dolphins -- Chapter 15. Life History Parameters, Sociobiology, and Reproductive Strategies of Pilot Whales -- Chapter 16. Sex in Killer Whales: Behavior, Exogamy and the Evolution of Sexual Strategies in the Ocean’s Apex Predator -- Chapter 17. Beaked Whale Sexual Dimorphism, Mating Strategies, and Diversification -- Chapter 18. Sexual Behavior and Anatomy in Porpoises -- Chapter 19. Sperm Whale Reproductive Strategies: Current Knowledge and Future Directions -- Chapter 20. Reproductive Tactics in Baleen Whales -- Chapter 21. Gray Whale Sex, Reproductive Behavior, and Social Strategies -- Chapter 22. Bowhead Whale Reproductive Strategies -- Chapter 23. Right Whale Sexual Strategies and Behavior -- Chapter 24. Cetacean Sociality, Reproduction, and Conservation.
    Kurzfassung: Sex in Cetaceans provides an up-to-date review of multi-faceted aspects related to mating and reproduction in toothed and baleen whales. This open access book begins with discussions of sexual selection and anatomical traits related to mating and diversity between the sexes. The functions of non-conceptive copulations are reviewed as are different research techniques applied to explore sex in cetaceans. Authors and editors build knowledge of female and male social, mating, and parental strategies and tactics for several specific toothed dolphin/porpoise/whale species and baleen whale species. It concludes with a discussion of potential conservation efforts and ways to help especially beleaguered species and populations the world over. The volume is intended as a major primer of cetacean sex for undergraduate and graduate students, new and established researchers in the field, and the public wishing to learn more.
    Materialart: Online-Ressource
    Seiten: IX, 619 p. 123 illus., 112 illus. in color. , online resource.
    Ausgabe: 1st ed. 2023.
    ISBN: 9783031356513
    DDC: 577.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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