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  • 1
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XIII, 172 p. 32 illus., 31 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030364229
    Series Statement: Advances in Experimental Medicine and Biology, 1227
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.
    Abstract: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 162 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030502249
    Series Statement: Advances in Experimental Medicine and Biology, 1277
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Biochemical markers. ; Immunotherapy. ; Cancers. ; Biomarkers. ; Immunotherapy.
    Description / Table of Contents: 1 Tumor heterogeneity: challenges and perspectives for gastrointestinal cancer therapy -- 2 immune composition of gastrointestinal tract of Gut -- 3 Immunomarkers for detection of GI malignancies -- 4 Immuno-therapeutics of gastrointestinal malignancies -- 5 Immune cell therapy against gastrointestinal tract cancers -- 6 Immune checkpoint inhibitors in gastrointestinal malignancies -- 7 Monoclonal Antibody therapy against gastrointestinal tract cancers -- 8 Therapeutic Vaccines for Gastrointestinal Malignancies -- 9 Immuno-Oncology of Oesophageal Cancer -- 10 Association between IL6 gene polymorphisms and gastric cancer risk: A meta-analysis of case-control studies -- 11 Immuno-oncology of colorectal cancer -- 12 Immune targets in colorectal cancer -- 13 Applications of computational biology in gastrointestinal malignancies. .
    Abstract: This book reviews current immunotherapeutic strategies for gastrointestinal (GI) malignancies, including immune composition, immune checkpoint inhibitors, cell therapy, and peptide vaccines used to protect against esophageal, gastric, hepato-biliary, pancreatic and colorectal cancers. It also discusses the current challenges of using immunotherapy for the treatment of gastrointestinal malignancies. The book reviews highly sensitive and specific immunomarkers for the detection of GI malignancies, and examines therapeutic vaccines and the major cytokines involved in GI immunotherapy, as well as their basic biology and clinical applications. In closing, the book explores various aspects of computational biology for the detection and treatment of GI malignancies. .
    Type of Medium: Online Resource
    Pages: XII, 251 p. 34 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811564871
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    DDC: 571.978
    Language: English
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  • 4
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.
    Abstract: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .
    Type of Medium: Online Resource
    Pages: XI, 211 p. 24 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813367852
    Series Statement: Advances in Experimental Medicine and Biology, 1316
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.
    Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
    Abstract: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
    Type of Medium: Online Resource
    Pages: VII, 280 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811569302
    DDC: 571.978
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030471897
    Series Statement: Advances in Experimental Medicine and Biology, 1270
    DDC: 571.978
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Immunology. ; Metastasis. ; Cytology. ; Cancer Biology. ; Oncology. ; Immunology. ; Metastasis. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.
    Abstract: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
    Type of Medium: Online Resource
    Pages: VI, 203 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031095184
    DDC: 571.978
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.
    Abstract: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
    Type of Medium: Online Resource
    Pages: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756994
    DDC: 571.978
    Language: English
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  • 9
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Diseases. ; Immunology. ; Bioinformatics. ; Cancer Biology. ; Diseases. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Obesity induced chronic low-level inflammation and cancers -- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers -- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation -- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer -- Chapter 6. Immune response and oxidative stress in obesity induced cancer -- Chapter 7. Role of gene polymorphism in obesity and cancer -- Chapter 8. Therapeutic role of green tea in obesity and cancer -- Chapter 9. Effect of dietary phytochemicals in obesity and cancer -- Chapter 10. Resveratrol as anti-obesity and anticancer agent -- Chapter 11. EGCG as anti-obesity and anticancer agent -- Chapter 12. miRNAs as therapeutic target in obesity and cancer -- Chapter 13. In silico updates on lead identification for obesity and cancer -- Chapter 14. In vivo models for obesity and obesity related carcinogenesis -- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases -- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.
    Abstract: This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. .
    Type of Medium: Online Resource
    Pages: IX, 361 p. 38 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618468
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: The tumor microenvironment: focus on extracellular matrix -- Keratan Sulphate in the Tumour Environment -- Hyaluronan in the tumor microenvironment -- Fibronectin in the tumor microenvironment -- Matrix metalloproteinases role in tumor microenvironment -- Flipping the Molecular Switch: Influence of Perlecan and its Modifiers in the Tumor Microenvironment -- Heparan sulfate in the tumor microenvironment -- The role of Glypican-1 in the tumour microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components with the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newer generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book will be an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.
    Type of Medium: Online Resource
    Pages: XI, 181 p. 29 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030401467
    Series Statement: Advances in Experimental Medicine and Biology, 1245
    DDC: 571.978
    Language: English
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  • 11
    Keywords: Cancer. ; Medical microbiology. ; Cytology. ; Pediatrics. ; Cancer Biology. ; Medical Microbiology. ; Cell Biology. ; Pediatrics.
    Description / Table of Contents: The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
    Type of Medium: Online Resource
    Pages: XIII, 233 p. 34 illus., 23 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030430856
    Series Statement: Advances in Experimental Medicine and Biology, 1258
    DDC: 571.978
    Language: English
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  • 12
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    DDC: 571.978
    Language: English
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  • 13
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Nanotechnology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Nanotechnology. ; Biomedical Research.
    Description / Table of Contents: 1 Introduction -- 2 Barriers for tumor drug delivery -- 3 Tumor-targeted strategies -- 4 Tumor-responsive drug release strategies -- 5 Tumor diagnosis patterns -- 6 Tumor therapeutic modes -- 7 Carbon-based tumor-targeted systems -- 8 Silica-based tumor-targeted systems -- 9 Lipid-based tumor-targeted systems -- 10 Dendrimer-based tumor-targeted systems -- 11 Polymer-based tumor-targeted systems -- 12 Other new tumor-targeted systems -- 13 Clinical applications of tumor-targeted systems -- 14 Challenges and perspectives of tumor-targeted systems.
    Abstract: This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.
    Type of Medium: Online Resource
    Pages: VI, 463 p. 72 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551598
    DDC: 571.978
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Dermatology. ; Oncology. ; Cancer Biology. ; Dermatology. ; Oncology.
    Description / Table of Contents: Section I: Introduction -- Lessons learned from paleolithic models and evolution for human health: a snap shot on beneficial effects and risks of solar radiation -- Section II: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences (I) -- Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? -- Section III: Solar radiation, Vitamin D and human health -- Vitamin D status and cancer incidence and mortality -- Vitamin D receptors polymorphisms and cancer -- On the relationship between sun exposure and all-cause mortality -- Lindqvist PG (2020) Women with greater sun exposure habits seem to be healthier and to live longer. Are these results in contrast to other research? No -- Section IV: Epidemiology of skin cancer -- Epidemiology of skin cancer and UV radiation – update 2019 -- Solar UV exposure and mortality from skin tumors: an update -- Solarium Use and Risk for Malignant Melanoma: many open questions,not the time to close the debate -- Section V: Photocarcinogenesis of skin cancer -- Molecular biology of basal and squamous cell carcinomas -- Human papillomaviruses and skin cancer -- The immune system and pathogenesis of melanoma and nonnmelanoma skin cancer -- Section VI: The relevance of the vitamin D endocrine system for skin cancer -- Protection from ultraviolet damage and photocarcinogenesis by vitamin D compounds -- The role of classical and novel forms of vitamin D in the pathogenesis and progression of non-melanoma skin cancers -- The Vitamin D Receptor as tumor suppressor in skin -- Cancer prevention in skin and other tissues via cross-talk between vitamin D- and p53- signalling -- Section VII: Prevention and Management of Skin Cancer -- Sunscreens in the United States: Current Status and Future Outlook -- A handful of sunscreen for whole body application -- Sunlight, vitamin D and Xeroderma pigmentosum -- Update: Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs) -- Section VIII: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences – II. promise and outlook -- Ultraviolet exposure scenarios: balancing risks of erythema and cutaneous vitamin D synthesis -- The Paleolithic nutrition model in relation to ultraviolet light and vitamin D -- Index.
    Abstract: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‑exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
    Type of Medium: Online Resource
    Pages: XIV, 428 p. 83 illus., 28 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030462277
    Series Statement: Advances in Experimental Medicine and Biology, 1268
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Stem cells. ; Oncology. ; Medical microbiology. ; Cancer Biology. ; Stem Cell Biology. ; Oncology. ; Medical Microbiology.
    Description / Table of Contents: Chapter 1. Introduction to cancer stem cells -- Chapter 2. Types of Cancer Stem Cells -- Chapter 3. Isolation and Characterization of Cancer Stem Cells (CSCs) -- Chapter 4. Lung and Prostate Cancer Stem Cells -- Chapter 5. A differential role of miRNAs in regulation of breast cancer stem cells -- Chapter 6. Skin stem cells in cancer -- Chapter 7. Ocular Cancer stem cells: Advances in therapeutic interventions -- Chapter 8. Cancer Stem Cells and Tumour Aggressiveness -- Chapter 9. Therapeutic Implication of Cancer Stem Cells.-Chapter 10. Glioblastoma stem cells as a therapeutic target -- Chapter 11. Cancer stem cells and therapeutic angiogenesis -- Chapter 12. Cancer stem cells as a seed for cancer metastasis -- Chapter 13. Functionality of intron specific genes and cancer stem cells in the progression of colorectal cancer -- Chapter 14. Technological advancement in Cancer Stem Cell Research -- Chapter 15. Controversies in Isolation and Characterization of Cancer Stem Cells -- Chapter 16. Targeting therapies for cancer stem cells -- Chapter 17. Targeting Cancer stem cells by nanoenabled drug delivery -- Chapter 18. Cancer Stem Cells in Patients Survival and Therapies in Cancer.-.
    Abstract: This book discusses the recent developments in the therapeutic implications of cancer stem cells for the effective diagnosis, prognosis, and treatment of cancer. It summarizes the various stem cells of common cancers including colon, pancreas, lungs, prostate, melanoma, and glioblastoma, and reviews the potential role of cancer stem cells in tissue aggressiveness, examining the functional contribution of cancer stem cells in the establishment and recurrence of cancerous tumors. Further, it explores the potential of cancer stem cells as novel therapeutic targets for the treatment and prevention of tumor progression. The book also discusses the various approaches for detecting, isolating, and characterizing different cancer stem cells and signaling pathways that control their replication, survival, and differentiation. Lastly, it explores the key features and mechanisms of drug resistance, chemo-resistance, and radio-resistance in cancer stem cells to improve therapeutic rationale.
    Type of Medium: Online Resource
    Pages: VII, 369 p. 65 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551208
    DDC: 571.978
    Language: English
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  • 16
    Keywords: Cancer. ; Biomedical engineering. ; Biochemical markers. ; Nanomedicine. ; Cancers. ; Biomedical Engineering and Bioengineering. ; Biomarkers. ; Cancer Nanotechnology.
    Description / Table of Contents: Chapter 1. Cancer of the Skin:Type and Etiology -- Chapter 2. Therapeutic intervention in skin cancer: Future prospects -- Chapter 3. Melanin Based Classification of Skin Types and Their Susceptibility to UV-induced Cancer -- Chapter 4. The Epidemiology of Skin Cancer Worldwide -- Chapter 5. UV-R induced Vitamin D synthesis and skin cancer -- Chapter 6. The role of microbiome in the induction, diagnosis and therapy of skin cancer -- Chapter 7. Skin Cancer: Molecular Biomarker for Diagnosis, Prognosis, Prevention and Targeted Therapy -- Chapter 8. Therapeutics intervention of skin cancer in the OMICS era -- Chapter 9. Artificial intelligence in Skin Cancer: Diagnosis and Therapy -- Chapter 10. Biomedical engineering in cancer diagnosis and therapy -- Chapter 11. Skin cancer treatment with Emphasis on Nanotechnology -- Chapter 12. Non-long coding RNA and role in skin cancer diagnosis and therapy -- Chapter 13. Potential of long non-coding RNAs in the diagnosis and therapy of melanoma skin cancer.-.
    Abstract: This book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.
    Type of Medium: Online Resource
    Pages: VIII, 250 p. 27 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811603648
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Genetics. ; Medical genetics. ; Cancers. ; Genetics and Genomics. ; Medical Genetics. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Polymorphisms and Mutation: What is difference? -- Chapter 2. Single nucleotide polymorphisms and pharmacogenomics -- Chapter 3. Impact of MicroRNA Polymorphisms on Breast Cancer Susceptibility -- Chapter 4. From inflammation to cancer: Role of genetic polymorphisms of Inflammatory Pathway Molecules in Gastric Cancer -- Chapter 5. Colorectal Cancer and genetic polymorphism in key regulatory low penetrance genes -- Chapter 6. Role of Genetic Polymorphisms in Breast Cancer -- Chapter 7. Genetic Polymorphisms of Essential Immune Pathogenic Response Genes and Risk of Cervical Cancer -- Chapter 8. Thyroid Cancer and genetic polymorphism -- Chapter 9. SNPs of TLRs and Bladder Cancer -- Chapter 10. Role of genetic polymorphisms in Lung Cancer.
    Abstract: This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.
    Type of Medium: Online Resource
    Pages: XXI, 339 p. 48 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813366992
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Tumors Immunological aspects. ; Cancer Treatment. ; Biochemistry. ; Metabolism. ; Cell biology. ; Immunology. ; Cancer Biology. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Therapy. ; Metabolic Pathways. ; Immunology.
    Description / Table of Contents: 1 Cancer Metabolism and Aggressive Tumor Behaviour -- 2 Immune Cell Metabolism and Function -- 3 Cancer Cell Metabolism Effecting Immune function -- 4 Immune Cell Metabolites as Fuel for Cancer Cells -- 5 Immuno-Onco metabolism and Resistance to Therapy -- 6 Targeting Immuno-Onco metaolism in Cancers -- 7 Timing of the major metabolic switches in immune cell activation and differentiation during cancer development.
    Abstract: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.
    Type of Medium: Online Resource
    Pages: X, 218 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811662263
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Biology. ; Cancer Treatment. ; Biotechnology. ; Molecular biology. ; Physiology. ; Cancer Biology. ; Biological Sciences. ; Cancer Therapy. ; Biotechnology. ; Molecular Biology. ; Physiology.
    Description / Table of Contents: Chapter 1. Introduction to Dietary Research and Cancer -- Chapter 2. Healthy Dietary Patterns and Cancer -- Chapter 3. Frequently Asked Diet and Nutrition Related Questions by Cancer Survivors -- Chapter 4. Dietary Recommendations of Worldwide Cancer Related Organizations -- Chapter 5. Outcome of ‘Diet and Cancer’ Related Clinical Trials -- 6. Diet and Cancer Epigenetics: A Step Towards Developing Cancer Epigenetic Diet -- 7. Role of Dietary Ingredients on Expression of Oncogenic and Tumor Suppressor miRNA -- 8. Can Diet Influence Metastasis? -- 9. Impact of Dietary Interventions on Cancer Stem Cells -- 10. Interaction of Dietary Metabolites with Anti-cancer Drug Targets -- 11. Revisiting the Anticancer Drug-Food Interactions -- 12. Functional Foods, Nutraceuticals, and Dietary Supplements in Cancer Prevention -- 13. Do Antioxidants Really Help Cancer Patients? The Puzzle of Benefits and Perils -- 14. Market of Dietary Supplements: Analysis of Health Benefits and Risk in Cancer -- 15. Cancer and Fasting: Can Fasting/Calorie Restriction (CR) or Fasting Mimicking Diet (FMD) Helps Fight Cancer? Molecular Basis of Fasting Response -- 16. Do Fasting, CR, and FMD Improves the Chemotherapy Response, Reduce Off Target Toxicities and Enhance Antitumor Immunity? Illusion or Clinical Reality? -- 17. Future Prospectus of Dietary Interventions in the Integrated Management of Cancer.
    Abstract: This book reviews all important aspects of dietary research associated with cancer with the aim of shedding new light on these conditions through combined understanding of traditional and new paradigms. The book is divided into 17 chapters, the first portion reinterprets healthy diets for cancer based on up-to-date evidence from a network science perspective, examining the dietary patterns, outcome of diet related clinical trials, emerging framework of molecular mechanisms and interactions of dietary interventions and their applications in personalized diet, ground realities of benefits and regulatory frame work for functional foods, nutraceuticals and supplements in cancer prevention and upcoming future prospectus in diet-cancer research.. The later part of the book discusses recent advances in understanding of the elaborative discourse on cancer and fasting, covering, for example, calorie restriction and fasting mimicking diet. Finally, different Dietary research and approaches are considered in the context of novel intervention for cancer research. Dietary Research in Cancer will be of interest for all researchers, nutritionists, students and clinicians in the field.
    Type of Medium: Online Resource
    Pages: XX, 197 p. 57 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811660504
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.
    Abstract: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
    Type of Medium: Online Resource
    Pages: XII, 202 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324291
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Metastasis. ; Lymphatics. ; Cancer Biology. ; Metastasis. ; Lymphatic System.
    Description / Table of Contents: Section 1: Genetic and Molecular Pathways of Cancer Growth and Metastasis -- Chapter 1. Hallmarks of Cancer: Molecular Underpinnings -- Chapter 2. Unifying concept of genomic changes: The mutational landscape of cancers -- Chapter 3. Tumor Microenvironment: Coconspirator in Tumorigenesis -- Chapter 4. Hallmarks of Metastasis: Molecular Underpinnings -- Chapter 5. Hereditary Cancer Syndromes and Cancer Metastasis -- Section 2: Pathology of Cancer Growth and Metastasis -- Chapter 6. Pathologic Assessment of Lymph Node Metastasis -- Chapter 7. Pathologic Assessment of Systemic or Distant Metastasis -- Chapter 8. The Role of Angiotropic Extravascular Migratory Metastasis in Metastases -- Section 3: Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment -- Chapter 9. Tumor Dormancy and Relapse Regulated by the Extracellular Matrix -- Chapter 10. Therapy-Induced Dormancy and Residual Disease -- Section 4: The Microenvironment of Site-Specific Metastasis - Isaac P. Witz -- Chapter 11. The Microenvironment of Site-Specific Metastasis -- Section 5: Circulating Cancer Cells and Liquid Biopsy -- Chapter 12. Circulating tumor cells and ctDNA in sarcomas -- Chapter 13. Liquid biopsy using cell-free tumor DNA for gastrointestinal cancers -- Chapter 14. Circulating tumor cells and ctDNA in prostate cancer.-Chapter 15. Circulating Tumor Cells in Lung Cancer -- Chapter 16. CTCs/ ctDNA and Brain Metastasis.-Chapter 17. Epigenetics and liquid biopsy in oncology: role in metastasis and clinical utility -- Chapter 18. Metabolic reprogramming of circulating tumor cells for metastasis -- Section 6: Lymphatic System and Cancer Metastasis -- Chapter 19. Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis -- Chapter 20. Lymphatic Specification and Development, EMT-MET, and Cancer Spread -- Chapter 21. Lymphangiogenesis, Lymph Nodes, Cancer Lymphangiogenesis and Metastasis -- Chapter 22. Immune cell trafficking in the lymphatics, hyaluronan biology and tumour metastasis -- Chapter 23. Lymphvascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis -- Chapter 24. Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis -- Chapter 25. Lymphedema: general pathophysiology, prevention and management in invasive cancer -- Section 7: Radiological Imaging of Early Cancer and Cancer Metastases -- Chapter 26. Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease -- Chapter 27. Imaging Modalities in the Detection and Diagnosis of Metastatic Disease -- Chapter 28. Imaging of Bone Metastases -- Chapter 29. Imaging of Lung and Soft Tissue Metastases -- Chapter 30. Image-Guided Biopsy and Intervention for Metastatic Disease -- Section 8: Sentinel Lymph Node Surgery for Solid Cancer. Chapter 31. Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy -- Chapter 32. Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 33. Sentinel node navigation surgery for upper gastrointestinal cancer -- Chapter 34. Sentinel Lymph Node Mapping in Non-Small Cell Lung, Colon, and Thyroid Carcinomas -- Section 9: Surgical Treatment of Primary and Metastatic Cancer -- Chapter 35. The efficacy and evolution of surgical management based on cancer biology -- Chapter 36. The role of surgery in managing primary and metastatic melanoma -- Chapter 37. The Role of Surgery in Managing Primary and Metastatic Breast Cancer -- Chapter 38. The role of surgery in managing primary and metastatic colorectal cancer -- Chapter 39. The Role of Surgery in Management of Gastric Cancer -- Chapter 40. The role of surgery in managing primary and metastatic hepatopancreaticobiliary cancers -- Section 10: Cancer Metastasis to the Lung -- Chapter 41. Metastatic disease of the lung -- Section 11: Cancer Metastasis to the Liver -- Chapter 42. Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases -- Chapter 43. Regional Arterial Infusional Therapy as a Means of Controlling Hepatic Metastases -- Section 12: Cancer Metastasis to the Bone -- Chapter 44. Molecular Mechanisms of Metastasis to the Bone.-Chapter 45. Surgical Management of Metastatic Disease to the Upper Extremity -- Chapter 46. Surgical Management of Metastatic Disease to the Lower Extremity -- Chapter 47. Surgical management of metastatic disease to the pelvis -- Chapter 48. Surgical Management of Metastatic Disease to the Spine -- Chapter 49. Interventional radiology techniques for management of skeletal metastases -- Section 13: Cancer Metastasis to the Brain and the Nervous System -- Chapter 50. Brain Metastases: Overview and Molecular Mechanisms -- Chapter 51. Indications and Techniques for Surgical Intervention in Patients with Metastatic Brain Tumors -- Chapter 52. Brain Metastases: Current and Future pharmacological treatment -- Chapter 53. Radiotherapy for CNS Metastases -- Chapter 54. Leptomeningeal Carcinomatoses -- Section 14: Urologic Cancer and 1st Patterns of Metastasis -- Chapter 55. Urologic Cancer and 1st Patterns of Metastasis -- Section 15: Biology and Clinical Aspects of Sarcoma Progression -- Chapter 56. Soft Tissue Sarcoma -- Chapter 57. Bone Sarcoma -- Chapter 58. Liposarcoma Metastasis -- Chapter 59. Desmoid Tumors.-Chapter 60. Atypical patterns of metastases: How do Sarcoma’s metastasize? -- Chapter 61. Tumor Immune Microenvironment of Soft Tissue Sarcoma -- Section 16: The Role of Radiation in the Treatment of Primary and Metastatic Cancer -- Chapter 62. Basic Principles of Radiobiology and Cancer Metastasis Prevention -- Chapter 63. Technical Innovations in the Delivery of Radiation Therapy -- Chapter 64. Radiation Therapy in the Definitive Treatment of Cancer -- Chapter 65. Radiation Therapy for Extracranial Oligometastatic Disease -- Chapter 66. Spine Radiotherapy -- Section 17: Immunotherapy of Solid Malignancies -- Chapter 67. Immunotherapy in Melanoma and Merkel Cell Cancer -- Chapter 68. Landscape of Immunotherapy in Lung Cancer -- Chapter 69. Immuno-oncologic Treatment of Genitourinary Malignancies -- Section 18: Current Topics -- Chapter 70. Personalized Systemic Cancer Therapy -- Chapter 71. Cancer Stem Cells and Their Role in Metastasis -- Chapter 72. HPV Induced Cancers -- Chapter 73. Microbiome and Cancer Metastasis -- Chapter 74. Application of Artificial Intelligence in Research on Cancer and Its Metastasis.
    Abstract: This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .
    Type of Medium: Online Resource
    Pages: XXIV, 806 p. 145 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030930844
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Tumors Immunological aspects. ; Immunotherapy. ; Cancer Genetic aspects. ; Stem cells. ; Cancer Biology. ; Cancer Therapy. ; Tumour Immunology. ; Immunotherapy. ; Cancer Genetics and Genomics. ; Cancer Stem Cells.
    Description / Table of Contents: Interdisciplinary Approach in Hepatobiliary Cancers -- Liver Cancer: Interdisciplinary Approach -- The Immune System in Liver Cancer: From Beginning to Progression -- The Tumor Microenvironment in Hepatocellular Carcinoma -- Metabolic Alterations of Hepatocellular Cancer Stem Cells -- Τhe Role of Senescence in NASH-related HCC -- Regulators of Genetic Risk for the Progression of Non-alcoholic Fatty Liver Disease to Hepatocellular Carcinoma: Reconstruction of Transcriptional Network and Signature-Based Metabolic Profiling -- Tumor Microenvironment and Immunotherapy in Advanced Biliary Tract Cancers -- Fibrosis and Immunotherapy in Hepatocellular Carcinoma -- Liver Cancer and the Curative Potential of Nanomedicine -- Locoregional Therapies for Hepatocellular Carcinoma -- Drug Resistance in Hepatocellular Carcinoma -- Liver Stereotactic Body Radiotherapy.
    Abstract: Hepatobiliary cancers, including hepatocellular carcinoma and biliary tract cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.
    Type of Medium: Online Resource
    Pages: XI, 365 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031445286
    Series Statement: Interdisciplinary Cancer Research, 3
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Oncology. ; Immunotherapy. ; Tumors Immunological aspects. ; Nanomedicine. ; Cancer Biology. ; Cancer Therapy. ; Oncology. ; Immunotherapy. ; Tumour Immunology. ; Cancer Nanotechnology.
    Description / Table of Contents: Interdisciplinary Approach in Gastrointestinal Cancers -- Gastrointestinal Cancers: What Is the Real Board of Microenvironment and the Role of Microbiota-Immunity Axis -- Epithelial-Mesenchymal Transition in Gastrointestinal Cancer: From a Basic to a Clinical Approach -- Metabolomics of Gastrointestinal Cancers -- Deregulation of Immune System in Gastric Cancer Development, How Immune Nutrition Might Restore the Functions of Immune Cells -- Helicobacter pylori Virulence Factors, Pathogenicity, and Gastric Cancer -- Gastric Cancer and Helicobacter pylori -- Role of Neuromodulators in Regulation of the Tumor Microenvironment of Gastric and Colorectal Cancers -- The Role of Tumor Microenvironment in Colon Cancer -- Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies -- The Interplay Between Immunity and Gut Microbiota in Colon Cancer -- Immunotherapy in Gastrointestinal Cancer Focusing on CAR-T Cell Therapy -- Development of Biocompatible Nanocarriers for the Treatment of Colorectal Cancer -- Challenges of Onco-therapeutics in Early Onset Colorectal Cancer -- Unintentional Weight Loss and Malnutrition After Esophageal Cancer and Treatment -- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer Treatment. The Tumor Microenvironment in Pancreatic Cancer and Challenges to Immunotherapy. .
    Abstract: Gastrointestinal cancers are among the most prevalent malignancies worldwide, with high rate of global cancer incidence and cancer-related death. Gastrointestinal cancers include esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, and liver cancer, which all, except the last one, are covered in this volume. The fourth volume of the “Interdisciplinary Cancer Research” series, entitled “Gastrointestinal Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of gastrointestinal cancers and novel immunotherapy opportunities and presents the most updated and peer-reviewed chapters on gastrointestinal cancers therapy. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XI, 404 p. 22 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031483714
    Series Statement: Interdisciplinary Cancer Research, 4
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Biomechanics. ; Cancer Biology. ; Biomechanics.
    Description / Table of Contents: Metabolism in the tumor microenvironment -- Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment -- Viral hepatitis, inflammation, and tumour microenvironment -- Effects of HIV on the tumor microenvironment -- GLI2-mediated inflammation in the tumor microenvironment -- Stellate Cells in the Tumor Microenvironment -- Endothelial Progenitors in the Tumor microenvironment -- Chimeric antigen receptors for the tumour microenvironment -- Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A dragon-Like Weapon in a Non-Fantasy Game of Thrones -- Multiple dynamics in tumor microenvironment under radiotherapy -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more. Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 208 p. 28 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030445188
    Series Statement: Advances in Experimental Medicine and Biology, 1263
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Novel techniques to study the bone-tumor microenvironment -- An emerging model for cancer development from a tumor -- microenvironment perspective in mice and humans -- Effects of Exercise on the Tumour Microenvironment -- Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment -- Multimodal molecular imaging of the tumour microenvironment -- Necrosis in the tumor microenvironment and its role in cancer recurrence -- The Multifaceted Effects of Autophagy on the Tumor Microenvironment -- The Sociobiology of Brain Tumors -- Tumor microenvironment conditioning by abortive lytic replication of oncogenic γ-herpesviruses -- The microbiome as a component of the tumor microenvironment -- Index.
    Abstract: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XI, 160 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357276
    Series Statement: Advances in Experimental Medicine and Biology, 1225
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Adipocytes in the tumour microenvironment -- Fibroblasts in the tumor microenvironment -- Mesenchymal stem cells in the tumor microenvironment -- Hepatic stellate cells in liver tumor -- Pancreatic stellate cells: The key orchestrator of the pancreatic tumor microenvironment -- Endothelial cells in the tumor microenvironment -- Lymphatic endothelial cell progenitors in the tumor microenvironment -- Oligodendrocyte progenitors in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.
    Type of Medium: Online Resource
    Pages: X, 129 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030371845
    Series Statement: Advances in Experimental Medicine and Biology, 1234
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Oncology. ; Medical genetics. ; Bioinformatics. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Oncology. ; Medical Genetics. ; Bioinformatics. ; Microsystems and MEMS.
    Description / Table of Contents: Module 1_ Introduction -- Module 2_ Cancer Metastasis -- Module 3_ Role of Transcriptomics in cancer treatment strategies -- Module 4_Computational approaches -- Module 5_Biostatistics and clinical oncology -- Module 6_Pharmacogenomics in cancer -- Chapter 7_Case studies.
    Abstract: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
    Type of Medium: Online Resource
    Pages: XVIII, 499 p. 59 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811510670
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Human physiology. ; Medicine Research. ; Biology Research. ; Gynecology . ; Cancer Biology. ; Human Physiology. ; Biomedical Research. ; Gynecology.
    Description / Table of Contents: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.
    Abstract: Symptoms of the breast in gravid women commonly represent physiological changes, however they may also be related to serious underlying breast disease; this challenging dilemma is aggravated by diagnostic and therapeutic limitations imposed by safety issues regarding the mother and fetus. A comprehensive coverage of all aspects of normal and pathologic breast changes during pregnancy and lactation, their diagnosis and management is provided in the present work. The organized structure of this book begins with gestational changes of the breast, while discussing safety, hazards, and arguments regarding diagnostic approaches. It then goes on by describing various clinical presentations and common and uncommon benign disorders during gravidity. The book then addresses pre-malignant lesions of the breast, opening the dialogue on how to manage these confusing lesions in pregnant and nursing women. It continues toward pregnancy-associated breast cancer, focusing on every facet of the problem, including epidemiology, diagnosis, treatment and complications, anesthetic considerations, prenatal care, and rare malignancies; and comes to an end by arguing main psychological concerns. In the midst of this orderly sequence fertility issues, pregnancy, and breastfeeding in women who have overcome their breast cancer are also discussed. This unique reference has been written by academic experts from different centers and diverse disciplines in a practical format. It is intended to be an ideal resource for every practitioner and specialist who manages complaints of gravid and nursing women or treats breast disorders in women of child bearing age.
    Type of Medium: Online Resource
    Pages: XXV, 216 p. 55 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030415969
    Series Statement: Advances in Experimental Medicine and Biology, 1252
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Tumor markers. ; Non-coding RNA. ; Cancers. ; Tumour Biomarkers. ; Non-coding RNAs.
    Description / Table of Contents: Chapter 1. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- Chapter 2. Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- Chapter 3. Regulation of Immune Cells by MicroRNAs and MicroRNA-Based Cancer Immunotherapy -- Chapter 4. Machine-Learning-Based Methods and Best Practices of MicroRNA-Target Prediction and Validation -- Chapter 5. Turning Data to Knowledge: Online Tools, Databases and Resources in MicroRNA Research -- Chapter 6. Bioinformatics Methods for Modeling MicroRNA Regulatory Networks in Cancer -- Chapter 7. Analysis of the p53/MicroRNA Network in Cancer -- Chapter 8. Machine Learning Using Gene-Sets to Infer miRNA Function -- Chapter 9. miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect on Disease -- Chapter 10. ClustMMRA v2: A Scalable Computational Pipeline for the Identification of MicroRNA Clusters Acting Cooperatively on Tumor Molecular Subgroups -- Chapter 11. 3D Modeling of Non-coding RNA Interactions.
    Abstract: This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.
    Type of Medium: Online Resource
    Pages: VII, 317 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031083563
    Series Statement: Advances in Experimental Medicine and Biology, 1385
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cytology. ; Cancer Microenvironment. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Cell Biology.
    Description / Table of Contents: Elastin in the Tumor Microenvironment -- Decorin in the tumor microenvironment -- Syndecan-1 in the tumor microenvironment -- Versican in the tumor microenvironment -- Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment -- Lipoproteins and the Tumor Microenvironment -- The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility -- Thrombospondin in Tumor Microenvironment -- Tenascin-C function in glioma: immunomodulation and beyond -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development. Furthermore, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include elastin, decorin, syndecan-1, versican, lipoproteins, brevican, thrombospondin, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part B updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapters authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.
    Type of Medium: Online Resource
    Pages: XIII, 178 p. 36 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484576
    Series Statement: Advances in Experimental Medicine and Biology, 1272
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Immunology. ; Oncology. ; Cancer Biology. ; Immunology. ; Oncology.
    Description / Table of Contents: Overview of Basic Immunology and Clinical Application -- Advances in Diagnostic Procedures and their Applications in the era of Cancer Immunotherapy -- Immunotherapy for Melanoma -- Immunotherapy in Lung Cancer: From a minor God to the Olympus -- Immunotherapy in Gastrointestinal Malignancies -- Current Landscape of Immunotherapy in Genitourinary Malignancies -- Immuno-oncology for Gynecologic Malignancies -- Immunotherapy for Neuro-Oncology -- Immunotherapy and Radiation -- CAR T-cells -- Skin Reactions to Immune Checkpoint Inhibitors -- Gastrointestinal Tract Adverse Events -- Immune-Related Adverse Events: Pneumonitis -- Hepatobiliary Adverse Events -- Immune Checkpoint Inhibitors (ICIs) Related Cardiotoxicity -- Renal Toxicity -- Immune-Related Oral, Otologic and Ocular Adverse Events -- Cancer Imaging in Immunotherapy -- The Microbiome in Immuno-Oncology -- New developments in the use of Patient-reported outcomes in Cancer Patients undergoing Immunotherapies.
    Abstract: Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.
    Type of Medium: Online Resource
    Pages: XII, 339 p. 44 illus., 35 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030410087
    Series Statement: Advances in Experimental Medicine and Biology, 1244
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Stem cells. ; Cancer Biology. ; Biomedical Research. ; Biotechnology. ; Stem Cell Biology.
    Description / Table of Contents: Preface -- Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. .
    Abstract: This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.
    Type of Medium: Online Resource
    Pages: XV, 167 p. 15 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030358051
    Series Statement: Advances in Experimental Medicine and Biology, 1220
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Oncology. ; Medical screening. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Oncology. ; Cancer Screening. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Chapter 1. Introduction: The Application of AI in Precision Oncology: Tailoring Diagnosis, Treatment, and the Monitoring of Disease Progression to the Patient -- Part I. Artificial Intelligence for Screening, Diagnosis, Monitoring in Precision Oncology -- Chapter 2. Application of AI in Novel Biomarkers Detection that Induce Drug Resistance, Enhance Treatment Regimens and Advancing Precision Oncology -- Chapter 3. Use of Artificial Intelligence in Implementing Mainstream Precision Medicine to Improve Traditional Symptom-driven Practice of Medicine: Allowing Early Interventions and Tailoring better-personalized Cancer Treatments -- Chapter 4. AI as a Novel Approach for Exploring ccfNAs in Personalized Clinical Diagnosis and Prognosis: Providing Insight into the Decision-Making in Precision Oncology -- Chapter 5. AI-Enhanced Digital Pathology and Radiogenomics in Precision Oncology -- Part II. Artificial Intelligence and Omics in Precision Oncology -- Chapter 6. Epigenetics Analysis Using Artificial Intelligence in the Era of Precision Oncology -- Chapter 7. Association of Metabolomics with AI in Precision Oncology: Emerging Perspectives for More Effective Cancer Care -- Chapter 8. Artificial Intelligence Application to Microbiomics Data for Improved Clinical Decision Making in Precision Oncology -- Part III. Artificial Intelligence in Cancer Therapy and the Clinical Applications -- Chapter 9. AI and Nanotechnology in Realizing the Goal of Precision Medicine: Tailoring the Best Treatment for Personalized Cancer Treatment -- Chapter 10. Artificial Intelligence-Based Medical Devices Revolution in Cancer Screening: Impact into Clinical Practice -- Chapter 11. Intelligent Drug Design and Use for Cancer Treatment: The Roles of AI and Precision Oncology in Targeting Patient-Specific Splicing Profiles -- Chapter 12. Applying Artificial Intelligence Prediction Tools for Advancing Precision Oncology in Immunotherapy: Future Perspectives in Personalized Care -- Chapter 13. Employing AI-Powered Decision Support Systems in Recommending the Most Effective Therapeutic Approaches for Individual Cancer Patients: Maximizing Therapeutic Efficacy -- Chapter 14. AI-Pathway Companion in Clinical Decision Support: Enabling Personalized and Standardized Care Along Care Pathways in Oncology -- Chapter 15. AI Tools Offering Cancer Clinical Applications for Risk Predictor, Early Detection, Diagnosis, and Accurate Prognosis: Perspectives in Personalised Care -- Chapter 16. Conclusion and Insights into the Future of AI in Precision Oncology.
    Abstract: This book highlights the use of artificial intelligence (AI), big data and precision oncology for medical decision making in cancer screening, diagnosis, prognosis and treatment. Precision oncology has long been thought of as ideal for the management and treatment of cancer. This strategy promises to revolutionize the treatment, control, and prevention of cancer by tailoring tests, treatments and predictions to specific individuals or population groups. In order to accomplish these goals, vast amounts of patient or population group specific data needs to be integrated and analysed to be able to identify key patterns or features which can be used to define or characterize the disease or the response to the disease in these individuals. These patterns or features can be as varied as molecular patterns or features in medical images. This level of data analysis and integration can only be achieved through the use of AI. The book is divided into three parts starting with a section on the use of artificial intelligence for screening, diagnosis and monitoring in precision oncology. The second part: Artificial intelligence and Omics in precision oncology, highlights the use of AI and epigenetics, metabolomics, microbiomics in precision oncology. The third part covers artificial intelligence in cancer therapy and its clinical applications. It also highlights the use of AI tools for risk prediction, early detection, diagnosis and accurate prognosis. This book, written by experts in the field from academia and industry, will appeal to cancer researchers, clinical oncologists, pathologists, medical students, academic teaching staff and medical residents interested in cancer research as well as those specialising as clinical oncologists.
    Type of Medium: Online Resource
    Pages: XIV, 315 p. 64 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031215063
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cell death. ; Cancer Biology. ; Cell Death.
    Description / Table of Contents: Preface -- Introduction -- The intersection of anoikis resistance and fatty acid metabolism in cancer -- Anoikis resistance in melanoma -- Anoikis mediated by stress-activated MAPK signaling pathways -- Metabolic Regulation of Anoikis -- Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells -- Role of the nuclear receptors in anoikis -- The roles of anoikis in cervical cancer -- Shc and the control of small GTPase dynamics in cellular anchorage -- Anoikis and the Human Gut Epithelium in Health and Disease -- Epithelial cell extrusion: the prelude to anoikis -- Microtubule modifications and mitochondria: role in anoikis.
    Abstract: This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of “anoikis”—the apoptosis that occurs when cells lack appropriate contact with the extracellular matrix—over 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field. This book provides both mechanistic and translational information regarding anoikis, in a convenient format. Mechanistically, the following topics will be addressed in detail: The role of MAP kinase signaling The role of Shc proteins as cellular anchorage sensors The role of cellular metabolism, and fatty acid metabolism in particular, and how they are affected by oncogenic transformation How epithelial cell extrusion – the prelude to anoikis—is regulated in normal and cancer cells The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: Colon cancer Melanoma Cervical cancer The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms. .
    Type of Medium: Online Resource
    Pages: VIII, 202 p. 6 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030738563
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Nanotechnology. ; Radiology. ; Molecular genetics. ; Cancer Biology. ; Nanotechnology. ; Radiology. ; Molecular Genetics.
    Description / Table of Contents: Chapter 1. Role of selected transcription factors in pancreatic and colorectal cancer growth and metastasis -- Chapter 2. Adiponectin in gastrointestinal malignancies -- Chapter 3. Small molecule-targeted therapies for GI cancers: success and failures -- Chapter 4. Epigenetic biomarkers for the detection of Gastrointestinal Cancers -- Chapter 5. CD151: A Lateral organizer and modulator of Tumor microenvironment in gastrointestinal cancers -- Chapter 6. Targeting Pathways in GI Malignancies -- Chapter 7. Identification of Potential Key Genes Involved In Progression of Gastric Cancer Using Bioinformatics Analysis -- Chapter 8. Recent Development in the biomarkers for the gastric cancer -- Chapter 9. Gastric Cancer and it’s remedy -- Chapter 10. An intergenic variant rs4779584 between SCG5 and GREM1 contributes to the increased risk of colorectal cancer: A meta-analysis -- Chapter 11. Phytochemicals plus nanomaterial’s on colorectal cancer -- Chapter 12. Pancreatic Ductal Adenocarcinoma and Type 2 Diabetes Mellitus: Distant Relatives or the Close Ones? -- Chapter 13. Tumor Biomarkers and Diagnosis of Pancreatic Adenocarcinoma -- Chapter 14. Immunotherapy in Gastrointestinal Malignancies -- Chapter 15. The Role of HIF-1α in Hepatocellular Carcinoma.
    Abstract: This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.
    Type of Medium: Online Resource
    Pages: XII, 259 p. 53 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811554711
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
    Abstract: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
    Type of Medium: Online Resource
    Pages: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031162862
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancers. ; Cancer Therapy. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Chapter 1 An introduction to breast cancer -- Chapter 2 Current treatment approaches to breast cancer. Chapter 3 Introduction to cell cycle and its regulators -- Chapter 4 Cell cycle and cancer -- Chapter 5 cell cycle dysregulation in breast cancer -- Chapter 6 Molecular Subtypes of breast cancer and CDK dysregulation -- Chapter 7 Breast tumor micro environment and CDks -- Chapter 8 CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis -- Chapter 9 CDK1 Dysregulation in Breast Cancer -- Chapter 10 CDK4/CDK6 dysregulation in estrogen positive receptor breast cancers -- Chapter 11 Therapeutic implications of CDKs in Breast Cancer -- Chapter 12 Novel CDK Inhibitors in Breast Cancer -- Chapter 13 Targeting CDKs with other chemotherapeutic drugs- A combinatorial approach -- Chapter 14 CDKs in cell-cycle progression and therapeutic strategies in Human breast cancer -- Chapter 15 CDk inhibitor for treatment of breast cancer -- Chapter 16 Response of therapy in cell cycle regulatory genes in breast cancer -- Chapter 17 Different cyclins and their significance in Breast cancer.
    Abstract: This book highlights the interrelation between cell cycle regulators and breast cancer phenotypes. It reviews the roles of Cyclin-Dependent Kinases (CDK) in driving cell cycle progression, cell cycle checkpoints and dysregulation in breast cancer. It also examines the prognostic significance of CDKs in breast cancer. and CDK inhibitors for the treatment of metastatic breast cancer. Further, the book discusses the role of different G1 cyclins in differentiation, chromosome stability, and transcriptional regulation in breast cancer. Additionally, it examines the role of immunogenic effects of CDK inhibitors, the mechanism of resistance and the current clinical trials in breast cancer treatment. Towards the end, the book explores cell cycle regulation as an attractive target for targeted drug therapy in breast cancer. This book is a comprehensive yet concise resource for oncologists and researchers interested in exploring the therapeutic potential of Cyclin-Dependent Kinases in breast cancer.
    Type of Medium: Online Resource
    Pages: XVII, 373 p. 133 illus., 92 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811989117
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cancer Biology. ; Medical Microbiology. ; Biomedical Research. ; Human Physiology. ; Immunology.
    Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.
    Abstract: This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.
    Type of Medium: Online Resource
    Pages: XII, 509 p. 31 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679514
    Series Statement: Physiology in Health and Disease,
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.
    Abstract: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: X, 494 p. 40 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030997083
    Series Statement: Biology of Extracellular Matrix, 11
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Cancer Epidemiology. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Epidemiology. ; Cancer Genetics and Genomics.
    Description / Table of Contents: Module 1_Overview of Breast Cancer -- Module 2_Cell and Molecular Biology of Breast Cancer-Diagnosis and Prognosis -- Module 3_Breast Cancer Treatment.
    Abstract: This book provides detailed information on the etiology, pathogenesis, diagnosis, prognosis, and treatment strategies for breast cancer. The first section of the book presents epidemiology, risk factors, histopathological, immunohistochemistry, and molecular subtypes of breast cancer based on the receptor status. It also discusses the association of breast cancer with other hormone-sensitive cancers. The second section of the book covers cover BRCA1 and BRCA2-associated breast carcinogenesis, early-stage progression of breast cancer, and noninvasive biomarkers for the early detection of breast cancer. It also discusses the role of epigenetic modifications and non-coding RNAs in breast cancer metastasis and explores these as the biomarkers and therapeutic targets for breast cancer therapy. Further, it discusses the role of fibrinolytic mechanisms and circulating tumor cells in breast cancer diagnosis, prognosis, and treatment. The book also provides an update on oral poly(ADP-ribose) polymerase (PARP) inhibitors to treat breast cancer. Finally, it offers potential new options for personalized therapies for breast cancer patients, including optimizing drug dosage and identifying genetic changes associated with cancer symptom occurrence and severity.
    Type of Medium: Online Resource
    Pages: XVII, 536 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811901973
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Endocrinology. ; Pathology. ; Cancer Biology. ; Endocrinology. ; Pathology.
    Description / Table of Contents: 1. Biophysiology of the uterus: development, cyclic changes, menopause -- 2. Hormonal effects in reproductive technology (ovulation stimulation, in vitro fertilization) -- 3. Hormonal role and therapy in common benign uterine lesions: endometrial polyps, leiomyomas, adenomyosis -- 4. Endometrial hyperplasia; precancerous lesions of the endometrium. Hormone therapy -- 5. Endometrial Carcinoma. Endometriosis, Hormonal Role in Carcinogenesis. Hormonal Therapy -- 6. Menopausal Hormone Therapy. Contraceptives -- 7. Replacement hormone therapy for gender dysphoria and congenital sexual anomalies -- 8. Hormone therapy for endometrial neoplasia related to breast cancer therapy (Tamoxifen) -- 9. Endometrial histopatholigic changes in hormonal therapy (contraceptives, ovulation stimulation, hormone replacement therapy, hormonal antitumoral therapy).
    Abstract: Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of “natural” hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women’s health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women’s health. .
    Type of Medium: Online Resource
    Pages: VIII, 185 p. 66 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030384746
    Series Statement: Advances in Experimental Medicine and Biology, 1242
    DDC: 571.978
    Language: English
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  • 43
    Keywords: Cancer. ; Cancer Genetic aspects. ; Oncology. ; Therapeutics. ; Cancer Biology. ; Cancer Genetics and Genomics. ; Oncology. ; Therapeutics.
    Description / Table of Contents: Chapter 1 Evolution of translational cancer therapeutics -- Chapter 2 Oncology: Way forward from clinical and molecular diagnosis to treatment -- Chapter 3 Oncogenic genomics alterations in cancer patient -- Chapter 4 Altered mRNA expression profiles in cancer patients -- Chapter 5 microRNAs and long non-coding RNAs as key targets -- Chapter 6 Oncogenic alterations translated into diagnostics -- Chapter 7 Precision medicine in oncology -- Chapter 8 Precision medicine – translation of individualistic treatment in oncology -- Chapter 9Pharmacogenetics and Pharmacogenomics in Precision Medicine -- Chapter 10 Pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines -- Chapter 11 Biomarkers in Precision Medicine in oncology -- Chapter 12 Bioinformatics and biostatistics in Precision Medicine -- Chapter 13 Omics in Precision medicine -- Chapter 14 Translational therapeutic targets : from bench to clinical trials -- Chapter 15 Strength of integartive genomic alterations, precision medicine and therapeutic targets as treatment choice in patient care.
    Abstract: This book describes translational cancer therapeutics and the way forward from clinical and molecular diagnosis to treatment. In addition, genomics alterations, microRNAs, and long non-coding RNAs translate precision medicine for the individualistic therapy of cancer patients. It describes the involvement of various pharmacogenetic factors in pharmacodynamic/pharmacokinetic (PD/PK) modulations of medicines. Indeed, the role of bioinformatics and biostatistics, considering the extensive data analysis serving precision medicine approaches, has also been entertained in the present book. Therefore, intended book demonstrates the successful medical evidence for the use of precision medicine in the treatment of cancer and its future clinical perspectives. It fills the gaps in cancer biology and precision medicine with its up-to-date content and well-designed chapters. It will serve as a valuable resource for science, medical students, and interdisciplinary researchers. It is a very welcome addition for the scientific community, research centers, and university-industry research collaborators to find out a complete capsular package about cancer drug targets, precision, and personalized medicine (including an introduction to cancer cell signaling, genomic alterations, miRNA targeting, pharmacogenetics, biomarkers, and metabolomics in precision medicine, etc.) at a single platform.
    Type of Medium: Online Resource
    Pages: XVI, 274 p. 23 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819915293
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer Nature Switzerland :
    Keywords: Cancer. ; Cancer Treatment. ; Stem cells. ; Cytology. ; Medical genetics. ; Immunology. ; Cancer Biology. ; Cancer Therapy. ; Cancer Stem Cells. ; Cell Biology. ; Medical Genetics. ; Immunology.
    Description / Table of Contents: Interdisciplinary Approaches in Cancer Research -- Role of Immune Cells in the Tumor Microenvironment -- Spatial Transcriptomic Approaches for Understanding the Tumor Microenvironment (TME) -- Role of Mesenchymal Stem/Stromal Cells in Cancer Development -- Cancer-associated Fibroblasts and Their Role in Cancer Progression -- The Role of Tumoroids in Cancer Research -- Myokines Expression in Cancer Cachexia -- Epigenetics in Cancer Biology -- Epigenetic Regulation of Cancer by Natural Touch: Phytochemicals and Epigenetic Regulation -- Telomerase Reverse Transcriptase in Humans: From Biology to Cancer Immunity -- Molecular Mechanisms of Metal-induced Carcinogenesis -- Epi-drugs Targeting RNA Dynamics in Cancer -- Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management -- Malignancies in Inborn Errors of Immunity -- Hematopoietic Stem Cell Transplantation in Patients with Inborn Errors of Immunity and Malignancy -- Personalized Immuno-oncology with Immunodeficiency Mouse Models -- Allergy and Cancer: New Perspectives -- Depression and Cancer: the Inflammatory Bridge -- Impact of Cancer-Related Sarcopenia on Systemic Immune Status -- Surveillance of Subclinical Cardiovascular Complications in Childhood Cancer Survivors: Exercise as a Diagnostic and Therapeutic Modality.
    Abstract: Cancer is a major public health concern and one of the leading causes of death. There is no simple solution for this complex disease, therefore interdisciplinary approaches might help to find solutions to many unanswered questions and challenges about cancer. The rapid flow of interdisciplinary research in cancer during recent years has increased our understanding of the nature of cancers. Such interdisciplinary approaches could be helpful for both the diagnosis and the development of more effective therapeutic strategies. The “Interdisciplinary Cancer Research” series publishes comprehensive volumes on different cancers and presents the most updated and peer-reviewed articles on human cancers. Over the past decade, increased cancer research has greatly improved our understanding of the nature of cancerous cells which has led to the development of more effective therapeutic strategies to treat cancers. This interdisciplinary series is of special value to researchers and practitioners working on cell biology, immunology, hematology, biochemistry, genetics, oncology and related fields. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN).
    Type of Medium: Online Resource
    Pages: XI, 611 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324581
    Series Statement: Interdisciplinary Cancer Research, 1
    DDC: 571.978
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Medicine, Preventive. ; Health promotion. ; Emigration and immigration. ; Medical policy. ; Diseases. ; Integrated Geography. ; Health Promotion and Disease Prevention. ; Human Migration. ; Health Policy. ; Diseases.
    Description / Table of Contents: Chapter1: Introduction -- Chapter2: Migration, Social Capital, and Health -- Chapter3: Disease Patterns: Communicable and Non-communicable -- Chapter4: Environmental Risks to Health -- Chapter5: Health Literacy of Migrants: Environmental Risks to Health -- Chapter6: Health Literacy of Migrants: Infectious and Non-Communicable Diseases -- Chapter7: Social Capital and Acculturation -- Chapter8: Social Capital and Health. .
    Abstract: This book brings readers the first scientific publication, using a mixed-method approach, on the internal migration dynamics regarding disease ecologies of informality and the interactions between social capital, lifestyles, health literacy, and health outcomes in the context of informal settlements in two developing countries - Ghana and Uganda. Through the prism of the concepts of place and scale, the book demonstrates the myriad of ways by which place or context directly and indirectly influence migrant's health knowledge, literacy, and outcomes in poor urban slums. Readers will learn about the multi-faceted linkages between social capital, acculturation, and health in places of deprivation via quantitative methods (e.g. surveys) and qualitative methods such as focus group discussions, in-depth interviews, concept mapping, and body health mapping. Chapters 1-2 provide an overview of internal migration into urban slums of Ghana and Uganda, and discuss the intersections between migration, social capital, and health in a global context. Chapters 3-7 address disease patterns, environmental risks to health, health literacy of migrants, social capital and acculturation, and social capital and health. The book will be of interest to professors and students, as well as policy makers in low to middle income countries for planning targeted interventions. .
    Type of Medium: Online Resource
    Pages: XVI, 153 p. 42 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030246938
    Series Statement: Global Perspectives on Health Geography,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Medical informatics. ; Geographic information systems. ; Medical economics. ; Medical care. ; Integrated Geography. ; Health Informatics. ; Geographical Information System. ; Health Economics. ; Health Care.
    Description / Table of Contents: Chapter 1 -- Introduction. Chapter 2 -- The shape of Japan: methods and data. Chapter 3 -- Death across life courses. Chapter 4 -- Cancer deaths. Chapter 5 -- Deaths from cerebrovascular and cardiovascular diseases. Chapter 6 -- Other major causes of death. Chapter 7 -- Synthesis.
    Abstract: This new health atlas of Japan presents a series of maps about the health of the contemporary Japanese population, i.e. detailed maps of health indicators in small areas using cartograms. This is the first comprehensive small-area based health atlas about contemporary Japan using vital statistics from 1995-2014. Each map is supplemented with concise explanations written by leading epidemiologists and health geographers in Japan. The book employs various cutting-edge methods in spatial epidemiology, Bayesian spatial smoothing for the reliable mapping of mortality indices, advanced cartographic transformations using the concept of aerial cartograms, and summary statistics of socioeconomic health inequalities. The atlas highlights geographical aspects of social gradients in health by comparing mortality maps with distribution of deprivation index during the recent long-lasting economic stagnation period of Japan known as the lost decades. This health atlas will be a useful resource for international comparisons between Japan and other advanced countries in terms of health and related socioeconomic disparities between regions. It will be of interest to public health practitioners, administrators, researchers and students working on health geography and public health.
    Type of Medium: Online Resource
    Pages: XXIX, 343 p. 336 illus., 335 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030227074
    Series Statement: Global Perspectives on Health Geography,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    Keywords: Geography. ; Physical geography. ; Environment. ; Agriculture. ; Biotic communities. ; Biodiversity. ; Geography. ; Earth System Sciences. ; Environmental Sciences. ; Agriculture. ; Ecosystems. ; Biodiversity.
    Description / Table of Contents: I General Part -- Part A - Ecological Basics (Autoecology) -- Part B - Ecological Basics (Synecology) -- Part C - Ecological Systems and Ecosystem Biology -- II Special Part -- Part D - ZB I: Zonobiome of the evergreen tropical rainforest or equatorial humid diurnal climate -- Part E - ZB II: Zonobiome of savannas, deciduous forests and grasslands of the tropical summer rainfall region -- Part F - ZB III: Zonobiome of hot deserts or subtropical arid climate -- Part G - ZB IV: Zonobiome of hardwoods or Mediterranean winter rainfall regions -- Part H - ZB V: Zonobiome of laurel forests or warm temperate humid climate -- Part I - ZB VI: Zonobiome of winter barren deciduous forests or temperate nemoral climate -- Part J - ZB VII: Zonobiome of steppes and cold deserts or arid temperate climate -- Part K - ZB VIII: Zonobiome of hardwood forests or temperate arid climate. Part K - ZB VIII: Zonobiome of taiga or cold temperate boreal climate -- Part L - ZB IX: Zonobiome of tundra or arctic climate -- Part M - Summary, conclusions -- III Final part.
    Abstract: Vegetation, soil and climate are the most important components of ecological systems. The book presents a compact synthesis of our current knowledge of the ecology of the Earth and is thus the basis for understanding the major interrelationships in a global perspective. In the first part, with a rich endowment of illustrations and photographic material, the well-introduced book deals with the essential processes and operations on the Earth's surface that lead to the formation of the vegetation cover with its distinctive zonation. In the second part, the individual vegetation zones as large-scale ecosystems (i.e. zonobiomes of the biosphere) are consistently described comparatively according to certain criteria. In a short and compact form, the main characteristics and structures as well as examples of ecosystem processes are discussed. The large-scale ecosystems are also the basis and reference system for all anthropogenic changes that have drastically altered vegetation over the last millennia, but especially in the 20th century. This book is a translation of the original German 1st edition Vegetation und Klima by Siegmar-W. Breckle and M. Daud Rafiqpoor, published by Springer-Verlag GmbH Germany, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. Authors Siegmar-W. Breckle long-time professor and head of the Department of Ecology at the University of Bielefeld (Germany). He continued the multi-volume work "Ecology of the Earth" by Heinrich Walter, published numerous articles and books on the ecology of many regions, especially the drylands combined with countless study trips around the globe. His research in deserts, tropics and high mountains is the basis for the corresponding chapters in this book. M. Daud Rafiqpoor, long-time research associate of the Academy of Sciences and Literature in Mainz and coordinator of two ecologically oriented long-term projects of this academy ("Three-dimensional Landscape Classification of the Tropics and Subtropics" and "Biodiversity in Change"). Numerous study trips in almost all tropical and subtropical mountains of the world. Publication of many papers and books on the geography and ecology of tropical and subtropical high mountains and Afghanistan.
    Type of Medium: Online Resource
    Pages: XXIV, 557 p. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783662640364
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Human geography. ; Peace. ; Human rights. ; Geography. ; Human Geography. ; Peace and Conflict Studies. ; Human Rights. ; Politics and Human Rights.
    Description / Table of Contents: Chapter1. Introduction -- Chapter2, Towards a Legal Framework on Internal Displacement in South Sudan -- Chapter3. Mediating Protection of Forcibly Displaced Populations in the Frontlines of the Central African Republic -- Chapter4. The Adequacy of Law and Policy Frameworks on Internal Displacement in Ethiopia: A Critical Appraisal -- Chapter5. Beyond Accountability and Eminent Domain: Development Rights and Development-Induced Displacement in Kenya -- Chapter6. A Review of Land and Property Rights of Internally Displaced Persons in Zimbabwe: Steps Towards Restitution -- Chapter7. Internally Displaced Children in Nigeria: A Rights-Based Situational Appraisal -- Chapter8. Straddled Between Government Forces and Armed Separatists: The Plight of Internally Displaced Persons from the Anglophone Regions of Cameroon -- Chapter9. National Protection of Internally Displaced Persons in Africa: Law and Policy Beyond the Rhetoric.
    Abstract: This volume examines the protection of internally displaced persons (IDPs) through an interdisciplinary lens, with a focus on IDPs in Africa. The novelty of this book resonates from the fact that it explores national perspectives on internal displacement, with the aim of providing a well-grounded engagement on the subject of internal displacement, for which very little exists. The chapter authors are drawn from various disciplines and institutional backgrounds, and provide context-based analysis and examine the situation in countries with significant population displacement. The work is a timely engagement, as the issue of internal displacement has emerged as a pertinent concern in Africa. Each of the chapters in this book draw on significant context-based knowledge and on issues for which there is a need for pertinent attention across the African countries. This book will be a significant reference point for researchers, professors, practitioners, judges, policy makers, international organizations, regional bodies, lawyers and scholars in the field of migration, forced migration, and regional institutions.
    Type of Medium: Online Resource
    Pages: VII, 113 p. 2 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030668846
    Series Statement: Sustainable Development Goals Series,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Urban policy. ; Law. ; Real estate business. ; Urban economics. ; Regional economics. ; Spatial economics. ; Geography. ; Urban Policy. ; Law. ; Real Estate Economics. ; Urban Economics. ; Regional and Spatial Economics.
    Description / Table of Contents: Chapter 1. Key determinants of spatial management systems in Europe (Paulina Legutko-Kobus, Maciej Nowak) -- Chapter 2. Determinants and effects of planning practice in Poland (PrzemysławŚleszyński) -- Chapter 3. Spatial development law in Poland and related problems (Maciej Nowak) -- Chapter 4. Determining the interdependence (including barriers and challenges) between legal regulations and planning practice (PŚ, MN PLK) -- Chapter 5. Summary and conclusions.
    Abstract: This book defines the dilemmas related to the interface between legal regulations and planning practice in the spatial management system. Based on specific case studies, it gives examples of possible problems and ways of solving them. It applies to Poland's standard and the determinants of spatial policy in other countries. It provides the basis for a developed international discussion and concretely suggests specific actions at local, regional and national levels.
    Type of Medium: Online Resource
    Pages: X, 119 p. 17 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030969394
    Series Statement: SpringerBriefs in Geography,
    DDC: 910
    Language: English
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  • 50
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geography. ; Human geography. ; Cultural geography. ; Cartography. ; Physical geography. ; Economic geography. ; Geography. ; Social and Cultural Geography. ; Cartography. ; Human Geography. ; Physical Geography. ; Economic Geography.
    Description / Table of Contents: Concept, types, collection, classification and representation of geographical data -- Representation of geographical data using graphs -- Diagramatic representation of geographical data -- Mapping techniques of geographical data.
    Abstract: Representation of geographical data using graphs, diagrams and mapping techniques is a key for geographers and for researchers in other disciplines to explore the nature of data, the pattern of spatial and temporal variations and their relationships, and formulation of principles to accurately understand and analyze features on or near the earth’s surface. These modes of representation also enable the development of spatial understanding and the capacity for technical and logical decision making. The book depicts all types of graphs, diagrams and maps, explained in detail with numerous examples. The emphasis is on their appropriate data structure, the relevance of selecting the correct technique, methods of their construction, advantages and disadvantages of their use, and applications of these techniques in analyzing and realizing the spatial pattern of various geographical features and phenomena. This book is unique in that it reflects a perfect correlation between theoretical knowledge of geographical events and phenomena and their realistic implications, with relevant examples using appropriate graphical methods. The book serves as a valuable resource for students, researchers, cartographers and decision makers to analyze and represent various geographical data for a better, systematic and scientific understanding of the real world.
    Type of Medium: Online Resource
    Pages: XXXII, 310 p. 161 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811665851
    Series Statement: Advances in Geographical and Environmental Sciences,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Human geography. ; Corporate governance. ; Geography. ; Regional Geography. ; Human Geography. ; Corporate Governance.
    Description / Table of Contents: Changing Community Governance in the Coastal Fishing Regions -- Examining Geographical Methods for Analyzing Relationships Among Actors in Fishing Ground Use -- Rethinking the State of Fisheries Cooperative Associations Through the Long-Term Consolidation Movement in Japan -- Fisheries Resource Governance in Hyogo Seto Inland Sea: Fishers, the Government, Research Institutes and Fisher’s Organizations -- Fishery Activities in Response to the Rapid Decline of the Herring Catch in Hokkaido -- Adaptive Capacity in Fishery Restoration Process at Tsunami-Affected Areas: Assets, Flexibility and Social Organization -- Adaptive Governance of Coastal Fisheries Resources in Response to Isoyake (Seaweed Deforestation). .
    Abstract: Japan’s fisheries sector is undergoing a major restructuring. The coastal ecological change and natural disasters such as tsunami demand that communities transform or organize resource governance anew. Under the national policy of decentralization to cope with the aging and declining population, the availability of local infrastructure, both physical and social, plays a significant role in the adaptive capacity of the community. This book presents the historical and spatial dynamics of coastal fisheries resource governance in response to different environmental changes, its socio-political context, and challenges raised by academicians. The reader will find the national trends and geographical patterns of the administrative restructuring in the communities and fisheries cooperatives from abundant maps and figures, as well as a rich description of adaptive governance in the scale of region and community by ecological-historical approaches. Comparative analysis of the communities provides a practical framework to understand a variety of local resources in Japan’s coastal regions, which will serve as a guide to the development of alternative adaptive governance in community-based small-scale fisheries in the world.
    Type of Medium: Online Resource
    Pages: XIII, 159 p. 47 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813342408
    Series Statement: International Perspectives in Geography, AJG Library, 13
    DDC: 910
    Language: English
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  • 52
    Keywords: Geography. ; Underwater archaeology. ; Geographic information systems. ; Cultural property. ; Archaeology. ; Anthropology. ; Geography. ; Maritime Archaeology. ; Geographical Information System. ; Archaeology and Heritage. ; Cultural Heritage. ; Anthropology.
    Description / Table of Contents: Chapter1. Remains of the shipwreck: an introduction to the Iberian maritime and underwater landscape -- Chapter2. A paradigm of inter and multidisciplinary research: The ForSEAdiscovery project as a case study -- Chapter3. Life and Death in the Spanish Carrera de Indias: ships, merchants, cargoes and routes -- Chapter4. Iberian Ships of the Early Modern Period -- Chapter5. Ship Types in Portugal -- Chapter6. The Iberian Peninsula between two Seas: Shipbuilding Revolution in the Mediterranean and the Atlantic Ocean, 14th–15th centuries -- Chapter7. An insight into Mediterranean naval architecture in the 16th century through the texts of Nicolò Sagri (1538–1571). A comparative perspective with Ibero-Atlantic shipbuilding -- Chapter8. From the Baltic Sea to Andalusia: North European timber (and traders) in 16th-century Seville -- Chapter9. Supplying timber for His Majesty’s fleets: forest resources and maritime struggle in Portugal (1621–1634) -- Chapter10. Historical Documents as sources for the study of shipbuilding in Spain -- Chapter11. Iberian Documents and Treaties on shipbuilding -- Chapter12. Maritime vocabulary in texts: Fray Joseph de Ledesma (1701) -- Chapter13. GIS application on 16th-18th centuries Iberian Shipwrecks.
    Abstract: This two-volume set highlights the importance of Iberian shipbuilding in the centuries of the so-called first globalization (15th to 18th), in confluence with an unprecedented extension of ocean navigation and seafaring and a greater demand for natural resources (especially timber), mostly oak (Quercus spp.) and Pine (Pinus spp.). The chapters are framed in a multidisciplinary and interdisciplinary line of research that integrates history, Geographic Information Sciences, underwater archaeology, dendrochronology and wood provenance techniques. This line of research was developed during the ForSEAdiscovery project, which had a great impact in the academic and scientific world and brought together experts from Europe and America. The volumes deliver a state-of-the-art review of the latest lines of research related to Iberian maritime history and archaeology and their developing interdisciplinary interaction with dendroarchaeology. This synthesis combines an analysis of historical sources, the systematic study of wreck-remains and material culture related to Iberian seafaring from the 15th to the 18th centuries, and the application of earth sciences, including dendrochronology. The set can be used as a manual or work guide for experts and students, and will also be an interesting read for non-experts interested in the subject. Volume 1 focuses on the history and archaeology of seafaring and shipbuilding in the Iberian early modern world, complemented by case studies on timber trade and supply for shipbuilding, analysis of shipbuilding treatises, and the application of Geographic Information Systems and Databases (GIS) to the study of shipwrecks.
    Type of Medium: Online Resource
    Pages: IX, 373 p. 22 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030864606
    DDC: 910
    Language: English
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  • 53
    Keywords: Geography. ; History. ; Political science. ; Human geography. ; Cartography. ; Geography. ; History. ; Political Science. ; Human Geography. ; Cartography. ; Regional Geography.
    Description / Table of Contents: Chapter 1 Drawing the lines, knowing the borders. An overview of recent scholarship on boundary-making and modern regimes of territorialization -- Part I. Boundary Treaties and Joint Commissions: Theoretical Foundations and Praxis on the Ground -- 2. Modern State Sovereignty as Geometric Purification of Territory. Delimitation Theories and Practices in the 1864 Spanish-Portuguese Boundary Treaty -- 3. Delimitation of the Spanish-Portuguese Border and the Controversy over La Contienda -- 4.From a Line on a Map to Realities on the Ground. The French-German Joint Boundary Commission at Work (1871-1877) -- 5. Mexican Geographer Engineers and the Demarcation of Mexico's Borders -- Part II. Contesting the Naturalness of Borders. Cartographic Practices, Geographical Knowledge and Territorial Issues -- 6. Borders on Paper, Borders on the Ground. Boundary Commissions Under the Treaty of Madrid and Their Role in the Reinvention of the Rio de la Plata Frontier (1752-1759) -- 7. Rights of Use vs. Natural Boundary: Demarcation of the Iraty Forest Massif (Western Pyrenees, 17th-19th Centuries) 8. A Water Borderline Adrift Between France and Spain. The Bidasoa and the Bay of Higuer at the End of the 19th Century -- 9. Demarcation of the Border of the Spanish Protectorate in Morocco (1913–1931): Chronicle of Failure -- Part III. Concluding Essay -- 10. Borders at the Global Turn.
    Abstract: This book brings together ten empirically rich and theoretically informed contributions that aim to clarify both geo-historical specificities and common transnational and global features of the cultures and practices of boundary making that shaped modern statehood. Written by scholars from Spain, France, Italy, Argentina, Brazil and Mexico, the essays included in this volume provide a comparative international perspective on the processes of border formation, as well as an integrative approach that seeks to strengthen the links between renewed geo-historical studies and more contemporary-oriented border studies. The book is addressed to a wide range of researchers, including geographers, historians, political scientists and specialists in geopolitics and the history of international relations.
    Type of Medium: Online Resource
    Pages: XII, 172 p. 35 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030969042
    Series Statement: Historical Geography and Geosciences,
    DDC: 910
    Language: English
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  • 54
    Keywords: Geography. ; Geography.
    Description / Table of Contents: Introduction -- Surveying the Earth through the ages -- Geodesy in the 21st century - Global reference systems and modern geodetic space observation techniques -- Our planet in focus - Phenomena of global change -- Social relevance of high-precision measurement of our planet from space.
    Abstract: How does your cell phone know where you are right now? How is our planet changing due to geodynamic processes and ongoing climate change? How can these changes be precisely measured from space in order to obtain reliable information about the melting of ice sheets or the threat to coastal regions from rising sea levels? This popular science book provides answers to these and many other socially relevant questions. It is aimed at interested non-professionals who want to learn more about our fascinating planet, but also at experts in natural sciences. You are taken on an exciting journey through time from the first surveys in ancient times to the satellite era, which is providing us with a global view of our home planet. Illustrative examples demonstrate how deeply global positioning and navigation with satellites pervade our daily life, and what fundamental contributions geodesy makes to understanding the Earth system and determining the effects of climate change. With interview contributions by Günter Hein, Harald Lesch and Stefan Rahmstorf. This book is a translation of the original German 1st edition Mission Erde by Detlef Angermann et al., published by Springer-Verlag GmbH Germany, part of Springer Nature in 2021. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). Content and language were subsequently revised by the authors. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors. The Authors Detlef Angermann holds a doctorate in geodesy and heads the Research Area Reference Systems at the Deutsches Geodätisches Forschungsinstitut of the Technical University of Munich. Roland Pail is Professor of Astronomical and Physical Geodesy at the Technical University of Munich. Florian Seitz is Professor of Geodetic Geodynamics and heads the Deutsches Geodätisches Forschungsinstitut of the Technical University of Munich. Urs Hugentobler is Professor of Satellite Geodesy and heads the Satellite Geodesy Research Facility of the Technical University of Munich.
    Type of Medium: Online Resource
    Pages: XII, 246 p. 74 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783662641064
    DDC: 910
    Language: English
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  • 55
    Keywords: Geography. ; Earth sciences. ; Environmental monitoring. ; Natural disasters. ; Geography. ; Earth and Environmental Sciences. ; Environmental Monitoring. ; Natural Hazards.
    Description / Table of Contents: Part1. Introduction and background -- Chapter1. Linking the impacts of tropical cyclones to the Sustainable Development Goals -- Part2. A Focus on Agriculture and Public Health -- Chapter2. Impacts of tropical cyclone Idai on cash crops agriculture in Zimbabwe -- Chapter3. A comparative study of flooding on food security of urban and rural households in Blantyre City and Chikwawa, Malawi -- Chapter4. Assessment of Cyclone Idai floods on local food systems and disaster management responses in Mozambique and Zimbabwe -- Chapter5. Impacts of Tropical Cyclones Idai and Kenneth on Public Health in Southern Africa -- Chapter6. Perspectives on safeguarding children in sustainable disaster mitigation in Zimbabwe -- Part3. Education, Water and Sanitation and Livelihoods -- Chapter7. Impacts of cyclone Idai and the road to recovery in education systems in Zimbabwe -- Chapter8. The Water Sanitation and Hygiene Perspective in Response to Cyclone Idai in Zimbabwe -- Chapter9. Struggles of Cyclone Idai floods survivors inhabiting spaces of vulnerability and reconstructing their fractured livelihoods -- Chapter10. The Reconstruction of Livelihoods by Survivors of Cyclone Idai in the Chimanimani District of Zimbabwe -- Part4. A Focus on Infrastructure and Settlement -- Chapter11. Planning for climate and cyclone resilient transport infrastructures in southern Africa: Lessons from Zimbabwe -- Chapter12. Impacts of Cyclone Idai on Human Settlements in Zimbabwe -- Chapter13. Social and physical vulnerability of settlements to hydro-climatic induced disasters: Lessons from Cyclone Idai in Zimbabwe -- Part5. Natural Resources, Oceans, Tourism and Other Losses -- Chapter14. The Impact of Cyclone Idai on natural and plantation forests in the Eastern Highlands of Zimbabwe -- Chapter15. Impact of Cyclone Idai on biodiversity and natural resources in Chimanimani District, Zimbabwe -- Chapter16. Impact of tropical cyclone Idai on tourism attractions and related infrastructure in Chimanimani, Zimbabwe -- Chapter17. Evidence of the impact of cyclones and floods on biodiversity and wildlife resources in Southern Africa -- Chapter18. Impact of cyclones and floods on seagrass habitats -- Chapter19. Economic Losses from Cyclones Idai and Kenneth, and Floods in southern Africa: Implications on Sustainable Development Goals -- Part6. The Policy Space -- Chapter20. Emerging Key Findings, Conclusions and Policy Recommendations.
    Abstract: Tropical cyclones in Southern Africa, also known as hurricanes or typhoons in other regions of the world, is a hot subject for academic research. This focus has been magnified by the need to consider tropical cyclones in the context of other global development agendas, that includes the 2030 Agenda for Sustainable Development and its inseparable 17 Sustainable Development Goals (SDGs), the Paris Agreement, the Sendai Framework for Disaster Risk Reduction and Habitat III’s New Urban Agenda. The ambitious SDGs challenge global and community leaders to make sure development addresses the nexus among poverty, inequality and employment creation, as well as care for the earth and its natural resources and biodiversity. The SDGs further present an agenda to eradicate hunger, bring quality education and sustain water and sanitation. The infrastructure development, human settlements, sustainable consumption and production, climate change, biodiversity and the ocean (blue) economy agendas are also pitched. Lastly, the 2030 Agenda for Sustainable Development encourages partnerships on delivering various programmes and projects at all spatial levels. However, as tropical cyclones continue to make multiple landfalls and ravage Southern Africa and other parts of the world, the achievement of the 2030 Agenda for Sustainable Development is threatened. To this end, this book addresses this gap by documenting the implications of tropical cyclones, drawing examples and case studies from recent tropical cyclones such as cyclone Idai and cyclone Kenneth that resulted in catastrophic impacts in 2019. The book comes as part of a series with three volumes. The other volumes include “Cyclones in Southern Africa Vol. 1: Interfacing the Catastrophic Impact of Cyclone Idai with SDGs in Zimbabwe” and “Cyclones in Southern Africa Vol 2: Foundational and Fundamental Topics”. Given the foregoing, the book is suitable as a read for several professionals and disciplines such as tourism and hospitality studies, economics, sustainable development, development studies, environmental sciences, arts, geography, life sciences, politics, planning and public health.
    Type of Medium: Online Resource
    Pages: XXVI, 322 p. 83 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030743031
    Series Statement: Sustainable Development Goals Series,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Geology. ; Physical geography. ; Economic geography. ; Human geography. ; Geography. ; Geology. ; Regional Geography. ; Physical Geography. ; Economic Geography. ; Human Geography.
    Description / Table of Contents: PART I - INTRODUCTION, POLITICAL GEOGRAPHY, ETHNIC GROUPS AND RELIGIONS -- Introduction -- I.1. General geographical features of Albania -- I.2. Historical and Political Geography -- I.3. Ethnic Groups and Religions -- I.3.2. Religions -- PART II - LANDSCAPE OF ALBANIA -- II.1. Geological construction -- II.2. The relief -- II.3. Climate -- II.4. Waters -- II.5. Soils -- II.6. Flora and fauna -- II.7. Albanian natural and cultural heritage -- PART III - DEMOGRAPHICS -- III.2. Sociocultural features -- III.2. Sociocultural features -- PART IV - THE ECONOMY -- PART V - GEOGRAPHIC REGIONS -- INDEX.
    Abstract: This book is one of the first to give a comprehensive and detailed overview of the complete geography of Albania in English. It highlights the most important and manifold potentials of nature, society and economy of Albania as well as development problems during different time periods. One focus lies on Albania's perspectives and challenges for the future. Beside natural aspects also topics such as migration, poverty, social situation, economy, urban development, regional disparities among others are discussed. This book appeals to academics and researchers of geography, regional development and related disciplines as well as teachers and students of geography, geology, natural sciences, social sciences, economics. The book is also attractive for media representatives, tourists and other interested individuals travelling to Albania.
    Type of Medium: Online Resource
    Pages: XXIV, 255 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030855512
    Series Statement: World Regional Geography Book Series,
    DDC: 910
    Language: English
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  • 57
    Keywords: Geography. ; Soil science. ; Agriculture. ; Ecology . ; Geography. ; Soil Science. ; Agriculture. ; Ecology.
    Description / Table of Contents: Application of RS-GIS-R for soil-land resources assessment, monitoring, and modelling -- Assessment of soil health and monitoring -- Soil and sediments pollution -- Microbiology of Soil and Sediments -- Soil Salinity and Sodicity -- Soil erosion and contamination from agricultural activities -- Digital soil mapping and carbon stock modelling -- Soil degradation and Risk assessment -- Agricultural Soil Pollution -- Risk Assessment of Heavy Metal Contamination -- Environmental Pollution of Soil and Anthropogenic Impact -- Soil pollution by industrial effluents and solid wastes -- Environmental impact and risk assessment -- Open source satellite data and GIS for soil resources mapping and monitoring -- Bioremediation in soil resources management and land use planning.
    Abstract: This book demonstrates the measurement, monitoring, mapping and modelling of soil pollution and land resources. This book explores state-of-the-art techniques based on open sources software & R statistical programming and modelling in modern geo-computation techniques specifically focusing on the recent trends in data mining/machine learning techniques and robust modelling in soil resources. Soil and agricultural systems are an integral part of the global environment and human well‐being, providing multiple goods and services essential for people worldwide and crucial for sustainable development. Soil contamination is an environmental hazard and has become a big issue related to environmental health. The challenge of the twenty-first century is to reduce the contaminant load and bring it to below permissible level. The contamination is not only a problem affecting local environments at the place of occurrence but also spreading to other regions because of easy transportation of pollutants. This leads to direct and indirect contamination of land and aquatic systems, surface water and groundwater, inducing significant risks for natural ecosystems. In this context, the spatial modelling, prediction, efficient use, risk assessment, protection and management of soil resources in the agriculture system are the key to achieving sustainable development goals and ensuring the promotion of an economically, socially and environmental sustainability future. The aim of this book on soil contaminants and environmental health: application of geospatial technology is to identify the soil and sediment quality, sources of contaminants and risk assessment and focuses on the decision-making and planning point of view through GIS data management techniques. This book covers major topics such as spatial modelling in soil and sediments pollution and remediation; radioactive wastes, microbiology of soil and sediments, soil salinity and sodicity, pollution from landfill sites, soil erosion and contamination from agricultural activities, heavy metal pollution and health risk; environmental impact and risk assessment, sustainable land use, landscape management and governance, soil degradation and risk assessment, agricultural soil pollution, pollution due to urban activities, soil pollution by industrial effluents and solid wastes, pollution control and mitigation in extreme environments. The content of this book is of interest to researchers, professionals and policy-makers whose work is in soil science and agriculture practices. The book equips with the knowledge and skills to tackle a wide range of issues manifested in geographic data, including those with scientific, societal and environmental implications.
    Type of Medium: Online Resource
    Pages: XXIV, 729 p. 208 illus., 188 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031092701
    Series Statement: Environmental Science and Engineering,
    DDC: 910
    Language: English
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  • 58
    Keywords: Environmental geography. ; Human geography. ; Medical care. ; Integrated Geography. ; Human Geography. ; Health Care.
    Description / Table of Contents: 1-Adolescent Health in the MENA Region: Determinants and Distribution -- 2-Adolescent nutrition: a focus on the MENA -- 3-Addressing Social Determinants of Oral Health among Adolescents from MENA -- 4-Knowledge, Attitude and Practice in relation to Vitamin D Deficiency among older adolescents -- 5-Activity among Adolescents from the MENA -- 6-Exploring Factors for Predictive Modelling of Obesity and Overweight in Adolescents: Application to MENA Region -- 7-Determinants of Knowledge in relation to Sexual and Reproductive Health of Adolescents in the Middle East and North Africa Region -- 8-Growth Assessment in Adolescence: Measurement and Interpretation for the Middle East and North Africa -- 9-Oral health of adolescents in the MENA region -- 10-Demographic and Geographic Variations in Respiratory and Allergic Conditions among Adolescents in the United Arab Emirates -- 11-The Epidemiology of Diabetes Mellitus among in adolescents and their determinants in from the Middle East and North Africa Region -- 12-HIV and sexual health in MENA’s adolescents.
    Abstract: This 2-volumeset focuses on adolescent health in the Middle East and North Africa region (MENA), and presents the latest research on the health risk behaviours and social behaviours that adolescents from the MENA region engage in. While there has been a surge in peer-reviewed research publications on population health in the MENA region in the last couple of decades, very few books offer a resource to address the diverse negative influences that disproportionately affect adolescents and children in the MENA region, including increased tobacco consumption culture, low emphasis on physical activity, increased sedentary behaviours, weak health policies, and societal issues related to displacement and political conflicts. These books offer a synthesis of current knowledge on adolescent health issues in the MENA region, and aim to provide evidence-informed adolescent health care practices that address current issues related to mental, physical, reproductive and nutritional health. Volume 2 focuses on nutritional and reproductive health in the MENA region, predictive modelling of obesity, determinants of sexual and oral health, HIV, and diabetes. The study will aid health care professionals, policy makers, government organizations and health program planners to assess current policies and practices related to adolescent health in the MENA region, and to identify the best courses of action moving forward. .
    Type of Medium: Online Resource
    Pages: X, 199 p. 20 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030921071
    Series Statement: Global Perspectives on Health Geography,
    DDC: 910
    Language: English
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  • 59
    Keywords: Geography. ; Space in economics. ; Sustainability. ; Development economics. ; Education. ; Geography. ; Spatial Economics. ; Sustainability. ; Development Economics. ; Education.
    Description / Table of Contents: Part 1 Geospatial technologies -- The effect of an open educational resource (OER) on student teachers‘ abilities to diagnose students‘ written argumentation skills -- Development of the Online Geospatial Problem-Solving Instrument: Investigating Elementary Students’ perceptual processes in geospatial problem-solving. -- A Spatial Knowledge Infrastructure for the Aegean Archipelago -- A Virtual Window to the World: Using Story Maps for SDG Visibility and Environmental Educatio -- Education for sustainable water consumption in multinational collaboration teachers training: Goals and Challenges -- Connecting Literature and Web Maps: Hungarian writers and poets online -- Part 2: Education, Geography and new Geospatial technologies and tools -- Teaching Geography with a Web GIS Approach -- Education for Sustainability Using Cloud-based Geographic Information Systems at University -- Comparative Dimensions of teaching Geography & History in Austria and in Israel, Migration of Vienna Jewry during the 1930s -- Geographiic Education for the Promotion of Spatial Citizenship: Collaborrative Mapping for Learning About the Local Environment in a Global Context -- Part 3: COVID-19 and post-COVID -19 -- The Art of Geographical Analysis of Covid-19 Related Data -- Development of a Synthetic Index of Social Vulnerability to Covid-19 in the City of Zaragoza (Spain) -- Students’ Satisfaction with Synchronous Online Learning in Times of COVID-19: A Case Study of Greek Geography Students -- Can Climate Crisis Go Viral? A Review of Climate Change Communication Lessons in the Aftermath of the COVID-19 Pandemic -- Towards a EU’s Sustainable and Humane Border Regime -- Part 4: Gepspatial technologies and application in agriculture -- Pest Management with Precision Farming Tools: the Case of the Olive Fly (Bactrocera Oleae) -- Sustainable Networking Solutions in Remote IoT Environments: Use Cases, Challenges and Solutions for Smart Agriculture.
    Abstract: Geography is a discipline with a profound interdisciplinary character focusing on studying the complex interactions between nature and society. Geography can advance the level of knowledge and awareness and provide important contributions to support the achievement of Sustainable Development Goals. This book explores some of these issues, while also disseminating and supporting the efforts of geographers worldwide to promote the implementation of the SDGs. It offers local and global perspectives to a variety of topics covered by the SDGs, such as: How do different actors such as universities, companies and education actors respond to Sustainable Development Goals, especially during the complex context of the COVID pandemic? What is the role of novel spatial technologies and open/big data in achieving SDGs and how can Geography assist? How are new eco-social challenges positioned in a post-pandemic global change? What are novel educational contexts and resources that can be used to transform society toward sustainability of socioecological systems? What conceptual frameworks and strategies can contribute to the construction of societies based on human welfare and the care of nature? This book is focused on innovative sustainability-oriented geographical research on the above (and more) topics that explore the diverse social, environmental, economic and cultural contexts at various spatial scales. It also includes chapters that report on geographical education initiatives in schools and universities, the implication of geographers in community-based learning and increasing community's awareness in terms of environment, climate change and sustainable development as well as chapters that make use of geospatial technologies (e.g., remote sensing, GIS, etc.) both in geographical research and education for sustainable development are particularly relevant for the book.
    Type of Medium: Online Resource
    Pages: VII, 325 p. 93 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031407475
    Series Statement: Key Challenges in Geography, EUROGEO Book Series,
    DDC: 910
    Language: English
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  • 60
    Keywords: Geography. ; Human geography. ; Landscape ecology. ; Sociology, Urban. ; Data mining. ; Geography. ; Human Geography. ; Landscape Ecology. ; Urban Sociology. ; Data Mining and Knowledge Discovery.
    Description / Table of Contents: Smart Geography: 100th Years Bulgarian Geographical Society -- Part I: Towards Smart Geography -- BGS and the Contemporary Progress of the Geographical Science Towards Smart Geography -- Smart Geographies and the Political Economy of Innovation and Inequality -- Evaluate Turkey's Climate Classification by Clustering Analysis Method.
    Abstract: This book focuses on new and innovative spatial approaches based on smart solutions and developed in the field of geography and related interdisciplinary fields such as urban and regional studies, landscape ecology and ecosystem services. It includes contributions from a conference dedicated to the 100th anniversary of the Bulgarian Geographical Society. In turn, the book reveals how 21st-century geography is expected to facilitate the development of human capital and the knowledge society, while also offering place-specific solutions for sustainable regional development and utilization of the planet’s natural and human capital to improve social wellbeing. This volume is intended for the global geographical research community, as well as professionals and practitioners in all fields that deal with space, including regional planners and environmental managers.
    Type of Medium: Online Resource
    Pages: VIII, 455 p. 141 illus., 113 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030281915
    Series Statement: Key Challenges in Geography, EUROGEO Book Series,
    DDC: 910
    Language: English
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  • 61
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Geographic information systems. ; Quality of life. ; Regional economics. ; Spatial economics. ; Sociology, Urban. ; Geography. ; Geographical Information System. ; Quality of Life Research. ; Regional and Spatial Economics. ; Urban Sociology.
    Description / Table of Contents: Chapter 1-Land use and land cover change: advancing with geographic information science -- Chapter 2-Land use in Ontario: challenges in land use classification -- Chapter 3-The golden horseshoe: land use from past to present -- Chapter 4-First nations reserves in Ontario: effects of urban sprawl -- Chapter 5-Archaeological heritage and urban sprawl: corridors of change -- Chapter 6-The cityscape: urban growth in Toronto -- Chapter 7-Land use and health perception -- Chapter 8-Environmental injustice in southern Ontario -- Chapter 9-Happiness and land use. .
    Abstract: This book presents a systematic analysis of challenges in the field of Geographical Information Systems and Science, geographical analysis, and regional science for Ontario, one of the fastest-changing provinces in Canada and one of North America's largest economic hubs. In nine chapters, the book offers advanced spatial analysis techniques and digital data content to integrate Geographic Information Systems (GIS) as tools to tackle regional and urban challenges. The chapters address the following main topics: 1) state-of-the-art approaches for regional discrepancies, 2) investigations of available methods for advanced spatial analysis, 3) identification of regional patterns and land use dynamics, 4) availability of Web 3.0 data content for regions without standardized data, and 5) the limitations and challenges of urbanization and its impact on landscape, heritage and ecosystems. The volume is divided into four sections dealing with key issues in Ontario, each addressing the use of GIS for crucial regional decision-making. The book will be of interest to researchers, undergraduate and graduate students, planners, regional scientists, and policy makers.
    Type of Medium: Online Resource
    Pages: IX, 240 p. 66 illus., 42 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031247316
    Series Statement: Advances in Geographic Information Science,
    DDC: 910
    Language: English
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  • 62
    Keywords: Environmental geography. ; Human geography. ; Urban policy. ; Sociology, Urban. ; Integrated Geography. ; Human Geography. ; Urban Policy. ; Urban Sociology.
    Description / Table of Contents: Cramped spaces, w(r)iggle room and everyday politics: An introduction -- Part 1: Everyday geographies of scholar activism -- Should I stay or should I go? Academic tempered radicalism in the era of ecological crisis -- Towards ‘minor’ methodologies or crisis as method -- Part 2: Repertoires of research methodologies and fieldwork experiences -- The sympoietic orchard: Everyday ways of co-creating an orchard -- Researching urban coworking spaces: Everyday life and reflexivity during the fieldwork -- Beyond the club: A feminist poetic inquiry to reimagine festive spaces and practices of the electronic scene in Paris -- Mapping sifikile – A place of home: Methodological reflections on hope from a coal frontier -- Madame Ruetabaga’s prefigurative politics at the urban fringes of Grenoble -- Digital practices on social media: New perspectives on the production of space and geopolitical inquiry -- Part 3: Embodied negotiations: Agency, survival, care -- Life at the margins: Women’s everyday practices as resistance in a working-class neighbourhood in Barcelona -- Digitalisation of working space: Women working from home in Turkey -- Home, work and everyday life: Gender dynamics in a mining city -- Epilogue.
    Abstract: The book provides a critical analysis of the geographies of everyday life, looking at how spatial practices craft w(r)iggle room to cope with the boundaries saturated by normativity, power relations, and inequalities. It explores the possibilities for making do with the everyday practices forming a way of living in cramped spaces. In this respect, early-career researchers and activists share their fieldwork experiences through an intersectional lens based on emerging research methodologies and scholar-activist practices. From their own vantage point, they look at their own contexts, practices, and research subjects at the level of everyday life. Spatial practices and place-based imaginaries from France, Finland, and Spain to Turkey and South Africa present a wide range of non-counter hegemonic yet enabling practices for transformation in everyday life. The contributors, trained in a variety of convergent disciplines concerned with everyday life and space (geography, geopolitics, architecture, urban planning, sociology, political sciences), discuss scholar-activist methodologies during the current crisis in contemporary academia, reflect on their research methodologies and research experiences, and inquire into the ways of embodied negotiations for agency, survival, and care. A group of early-career researchers and activists came together to seek out the possibilities of transformative change in everyday life during the peak periods of COVID-19. When researchers and activists were forced to stay at home in isolation, the authors met up online to discuss their subjectivities self-reflexively to challenge the distance between the researcher and “the field.” The book is the outcome of their collective production based on numerous meetings, writing workshops, and creative debates.
    Type of Medium: Online Resource
    Pages: XIV, 224 p. 23 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031465802
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 63
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geography. ; Landscape architecture. ; Landscape ecology. ; Geography. ; Landscape Architecture. ; Landscape Ecology.
    Description / Table of Contents: The logic of landscape pattern language -- The theoretical evolution and innovation of landscape pattern language -- landscape space units as the foundation of pattern language -- The C-3P analytical framework of landscape space -- The framework of landscape pattern language -- The space and design vocabulary of landscape pattern language -- spatial relations and reasoning of landscape pattern language -- Networks syntax and scaling of landscape pattern language -- Prospect of landscape pattern language using in practice.
    Abstract: This book presents a landscape pattern language framework for describing landscape spaces and offers a new approach to landscape expression and spatial reasoning. In addition to describing a conceptual model of landscape pattern language and its inner logical connections, the book discusses the functionality of landscape pattern language from both local and universal perspectives—effectively demonstrating that it can be used to highlight the individuality and characteristics of landscape space shaping. Given its scope, the book offers a valuable resource for all graduate students, lecturers, researchers, and practitioners in the areas of landscape architecture, landscape planning, and regional planning, especially ecological planning and design. .
    Type of Medium: Online Resource
    Pages: XXXIV, 422 p. 295 illus., 166 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811964305
    Series Statement: EcoWISE, Innovative Approaches to Socio-Ecological Sustainability,
    DDC: 910
    Language: English
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  • 64
    Keywords: Environmental geography. ; Climatology. ; Sociology, Urban. ; Economic development. ; Geography. ; Integrated Geography. ; Climate Sciences. ; Urban Sociology. ; Development Studies. ; Regional Geography.
    Description / Table of Contents: Systems Approach for Climate Change Impacts on Urban Health: Conceptual Framework, Modeling and Practice -- “SITE” (Societal-Institutional-Technical-Economic) Valuation framework : A case of drinking water facilities and services in slum areas of Hyderabad region -- Inequalities in access to water and sanitation: a case of slums in major states of India -- Chennai floods 2005, 2015: vulnerability, risk and climate change -- An environmental study of solid waste management system in of Chandrapur city, Maharashtra, India -- Linkages between Purdah Practice, Women Autonomy and Their Health Beliefs in India -- Development of urban heat island and its relation to heat waves -- Growing urbanization, health infrastructure and vector-borne diseases: A study in Khammam municipal corporation, Telangana state -- Maternal Reproductive Health: A Comparison between India and Empowered Action Group States -- Research Frontiers in Water, Environment and Human Health -- Impacts of resource consumption and waste generation on environment and its impact on human health: A study based on ecological footprint analysis -- The Impact Of Climate Change On Human Eyes -- Health and Well-being of Ageing Population in India: A Case Study of Kolkata -- Noise pollution and its consequences on urban health in Sylhet city -- Health Scenario in Delhi – Status and Recent Trends of Vector Borne and Water Borne Diseases in NCT of Delhi -- Quality of living, health and wellbeing of slum dwelling women domestic workers in Kolkata -- Urban Growth and Environment and Health Hazards in Kathmandu Valley, Nepal -- Impact of Urbanisation on Megacities’ Lakes Using Remote Sensing Technique – A Case Study of Water Quality Analysis in Ambattur Lake, Chennai, India -- Impacts of urbanization of ground water pollution – an emerging issue and some suggestions -- Evaluation of mass rapid transit system : A case study of Delhi -- The first survey of flood disaster Preparedness in Hanoi, Vietnam -- Tradition meets innovation: Herbal medicine as a sustainable source of anticancer agents -- Urban Health Infrastructure in Small Cities: Is it Availability or Accessibility? -- An approach to social sustainability in Chennai – understanding the dynamics of public places -- Water scarcity in Delhi: Mapping for solutions and the way forward. .
    Abstract: This book focuses on understanding urban vulnerability and risk mitigation, advancing good health and wellbeing, and analysing resilience measures for various Asian cities. Today, cities are the dominant human habitat, where a large number of environmental, social, cultural and economic factors have impacts on human health and wellbeing. Cities consist of complex, dynamic, socio-ecological, and technological systems that serve multiple functions in human health and wellbeing. Currently half of Asia’s population is urban, and that figure is expected to rise to 66 percent by 2050. Since urban areas are often most vulnerable to hazards, the people living in them need good health infrastructure facilities and technological support at various scales. As such, the need of the hour is to enhance the adaptive capacity, strengthen resilience, reduce vulnerability, and take risk mitigation measures in urban areas, which requires a systematic approach based on science–policy interface that is transformative, trans-disciplinary and integrative for a sustainable urban future. Global sustainable development goals are closely tied to urban human health and wellbeing: (1) the third of the United Nations’ Sustainable Development Goals is to “Ensure healthy lives and promote wellbeing for all at all ages” and (2) the eleventh is to “Make cities inclusive, safe, resilient and sustainable”. By addressing these goals, this book offers a highly useful resource for anyone concerned with healthy and resilient cities in Asia, today and tomorrow.
    Type of Medium: Online Resource
    Pages: IX, 459 p. 124 illus., 103 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811512056
    Series Statement: Advances in Geographical and Environmental Sciences,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Digital humanities. ; Open source software. ; Sustainability. ; Cartography. ; Geography. ; Digital Humanities. ; Open Source. ; Sustainability. ; Cartography.
    Description / Table of Contents: Chapter1. Introduction -- PartI. Mapping for the Goals on Poverty, Hunger, Health, Education, Gender, Water, and Energy -- Chapter2. Open Data Addressing Challenges Associated with Informal Settlements in the Global South -- Chapter3. Leveraging Spatial Technology for Agricultural Intensification to Address Hunger in Ghana -- Chapter4. Rural Household Food Insecurity and Child Malnutrition in Northern Ghana -- Chapter5. Where is the Closest Health Clinic? YouthMappers map their communities before and during the COVID-19 pandemic -- Chapter6. Cross-continental YouthMappers Action to Fight Schistosomiasis Transmission in Senegal -- Chapter7. Understanding YouthMappers Contributions to Building Resilient Communities in Asia -- Chapter8. Activating Education for Sustainable Development Goals through YouthMappers -- Chapter9. Seeing the World Through Maps: An Inclusive and Youth Oriented Approach -- Chapter10. Youth Engagement and the Water-Energy-Land Nexus in Costa Rica -- Chapter11. Power Grid Mapping in West Africa -- Chapter12. Mapping Access to Electricity in Urban and Rural Nigeria -- PartII. Youth Action on Work, Leadership, Innovation, Inequality, Cities, Production and Land -- Chapter13. Stories from Students Building Sustainability Through Transfer of Leadership -- Chapter14. Drones For Good: Mapping Out the SDGs Using Innovative Technology in Malawi -- Chapter15. Assessing YouthMappers Contributions to the Generation of Open Geospatial Data in Africa -- Chapter16. Mapping Invisible and Inaccessible Areas of Brazilian Cities to Reduce Inequalities -- Chapter17. Visualizing YouthMappers Contributions to Environmental Resilience in Latin America -- PartIII. Marking a Path to Goals on Sustainable Communities, Consumption, Climate, Oceans, Land, and Justice -- Chapter18. Youth Engagement and Participation in Mitigating Perennial Flooding in Kampala, Uganda using Open Geospatial Data -- Chapter19. Sustainable Mobility through Knowledge Exchange and Collaborative Mapping of Cycling Infrastructure: SIGenBici in Medellín, Colombia -- Chapter20. Wastesites.io: Mapping Solid Waste to Meet Sustainable Development Goals -- Chapter21. Mapping for Resilience: Extreme Heat Deaths and Mobile Homes in Arizona -- Chapter22. Mapping for Women’s Evacuation Plans during Climate-induced Disasters -- Chapter23. Sustainable Development in Oceania and the Role of Mapping for Women -- Chapter24. Sustainable Coastal Communities in the Anthropocene: Lessons from Crowd-Mapping Projects in Colombia -- Chapter25. Collaborative Cartography Making Riparian Communities Visible in Tefé, Amazonas, Brazil -- Chapter26. Open Mapping with Official Cartographies in the Americas -- Chapter27. Cities of the Future Need to be Both Smart and Just: How We Think Open Mapping Can Help -- PartIV. Supporting YouthMappers to Advance the SDGs through Institutions and Partnerships -- Chapter28. Mentoring Experiences in YouthMappers Chapters -- Chapter29. The Ecosystem Where YouthMappers Live and Thrive -- Chapter30. A Free and Open Map of the Entire World: Opportunities for YouthMappers within the Unusual Partnership Model of OpenStreetMap -- Chapter31. Youth and Humanitarian Action: Open Mapping Partnerships for Disaster Response and the SDGs -- PartV. The Paths Ahead -- Chapter32. Generation 2030: The Strategic Imperative of Youth Civic and Political Engagement -- Chapter33. Reflecting on the YouthMappers Movement.
    Abstract: This collection amplifies the experiences of some of the world’s young people who are working to address SDGs using geospatial technologies and multi-national collaboration. Authors from every region of the world who have emerged as leaders in the YouthMappers movement share their perspectives and knowledge in an accessible and peer-friendly format. YouthMappers are university students who create and use open mapping for development and humanitarian purposes. Their work leverages digital innovations - both geospatial platforms and communications technologies - to answer the call for leadership to address sustainability challenges. The book conveys a sense of robust knowledge emerging from formal studies or informal academic experiences - in the first-person voices of students and recent graduates who are at the forefront of creating a new map of the world. YouthMappers use OpenStreetMap as the foundational sharing mechanism for creating data together. Authors impart the way they are learning about themselves, about each other, about the world. They are developing technology skills, and simultaneously teaching the rest of the world about the potential contributions of a highly connected generation of emerging world leaders for the SDGs. The book is timely, in that it captures a pivotal moment in the trajectory of the YouthMappers movement’s ability to share emerging expertise, and one that coincides with a pivotal moment in the geopolitical history of planet earth whose inhabitants need to hear from them. Most volumes that cover the topic of sustainability in terms of youth development are written by non-youth authors. Moreover, most are written by non-majoritarian, entrenched academic scholars. This book instead puts forward the diverse voices of students and recent graduates in countries where YouthMappers works, all over the world. Authors cover topics that range from water, agriculture, food, to waste, education, gender, climate action and disasters from their own eyes in working with data, mapping, and humanitarian action, often working across national boundaries and across continents. To inspire readers with their insights, the chapters are mapped to the United Nations 17 Sustainable Development Goals (SDGs) in ways that connect a youth agenda to a global agenda. This is an open access book. .
    Type of Medium: Online Resource
    Pages: XXIII, 382 p. 258 illus., 251 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031051821
    Series Statement: Sustainable Development Goals Series,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Buildings Design and construction. ; Regional economics. ; Spatial economics. ; Sociology, Urban. ; Landscape architecture. ; Geomorphology. ; Geography. ; Building Construction and Design. ; Regional and Spatial Economics. ; Urban Sociology. ; Landscape Architecture. ; Geomorphology.
    Description / Table of Contents: Chapter 1 - Methodological introduction, research structure & state of the art -- Chapter 2 - Suburban shopping mall as Urban Fabric -- Chapter 3 - Suburban commercial fabric formative process -- Chapter 4 - Retail spaces Crisis and Future transformative process -- Chapter 5 – Conclusions -- Bibliography.
    Abstract: This book derives from observations of the contemporary built environment and its contradictions. The suburban retail spaces, specifically the suburban shopping mall, and the changes caused by them within urban organisms are the object of the investigation synthesized in the volume. The topic is very crucial for the development of the contemporary city. It constitutes at the same time a problem (large commercial structures' spread is 'destroying' traditional commercial urban fabrics) and an opportunity (shopping malls are the most vital parts of the new suburbs and can play the role of community nucleus in urban and suburban areas). Furthermore, the spread of e-commerce forces these structures to functional and spatial transformations that brings also a new relationship with the city. The analytical reading, supplemented by generative and design projections, is carried out by using the conceptual and methodological tools of urban morphology, specifically those of the typological processual approach. From this specific point of view, the suburban shopping mall is read as an organism (a complex system characterized by mutual solidarity and interdependence among component elements) in itself, and as a sub-organisms belonging to the largest territorial organism. The book is intended to offer, to operators, scholars, researchers, professionals and students, a reading and design method, to interpret an important aspect of the contemporary built environment by analyzing the suburban commercial space case. It offers at the same time a model applicable to other specific not-commercial cases, to defining paths for further research and design developments.
    Type of Medium: Online Resource
    Pages: XI, 96 p. 30 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030549916
    Series Statement: SpringerBriefs in Geography,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Geographic information systems. ; Peace. ; Geography. ; Geographical Information System. ; Peace and Conflict Studies.
    Description / Table of Contents: Part1. Sources, impacts, and the perspectives on resource conflicts -- Chapter1. Natural Resources, Conflict of Interests and their Management -- Chapter2. Sources, Impacts and Management of Natural Resources Conflicts -- Chapter3. Perspectives on Natural Resource Conflicts -- Part2. Participatory Mapping and PGIS applications in conflict management -- Chapter4. Participatory Mapping and management of natural resource conflicts -- Chapter5. The Development of Community-based GIS Applications -- Chapter6. The impact of geospatial data processing on conflict-supporting beliefs -- Chapter7. Case study: Participatory mapping and management of conflict of interests over allocation of resources within the Aboma Forest Reserve at Kofiase, Ghana -- Part3. Assessment of Participatory Mapping and PGIS applications in conflict management -- Chapter8. Important factors in successful Participatory Mapping and PGIS applications in conflict management -- Chapter9. Appraisal of the roles of Participatory Mapping and PGIS applications in conflict management -- Chapter10. Conclusion.
    Abstract: This book integrates spatial analysis into the study and management of conflicts, and offers a model in conflict studies that incorporates theoretical explanations of conflict, its causes, and impacts, with a geospatial strategy for intervening in disputes over allocation and use of natural resources (connects theory and practice). Alongside a theoretical analysis of resource conflicts and an account of Participatory Mapping and PGIS development, this book provides a case study of GIS applications in conflict mediation. The book also lays out a practical and straightforward demonstration of PGIS applications in conflict management using a real-world case study, and traces the Participatory Mapping and PGIS movements’ evolution, compares PPGIS and PGIS practices, and makes distinctions between traditional GIS applications and PGIS practice. The approach embodies the enhanced use of spatial information and media, sets of tools for analyzing, mapping, and displaying spatial data and a platform for participatory discussions that enhances consensus-building. The book, therefore, contributes to the search for novel approaches for managing current and emerging conflicts. With this book, resource managers, development practitioners, students, and scholars of Participatory Mapping and PGIS applications and conflict studies will be equipped with the principles, skills, and the tools they need to manage non-violent resource conflicts and keep the disputes from slipping into violence. The book will also be a valuable text for basic and advanced studies in Participatory Mapping and PGIS applications, Conflict Resolution and Conflict Management. .
    Type of Medium: Online Resource
    Pages: XXVI, 234 p. 11 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030741662
    DDC: 910
    Language: English
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    Keywords: Geography. ; Ecology . ; Geomorphology. ; Climatology. ; Biodiversity. ; Geography. ; Ecology. ; Geomorphology. ; Climate Sciences. ; Biodiversity.
    Description / Table of Contents: Geographic Uniqueness of the Sierra Nevada in the Context of the Mid-latitude Mountains -- Biotic Uniqueness of the Sierra Nevada as a Hotspot of Biodiversity -- Singular Cultural Landscapes of the Sierra Nevada -- Scientific Knowledge Generated in the Sierra Nevada: Bibliographic Review in WOS Since 1970 -- The Geological Setting -- Glacial Geomorphology of the Massif -- Reconstruction of Past Environments Using Lake Sedimentary Records -- Modern Periglacial Environment and Permafrost -- Variability and Recent Trends -- Snow Dynamics, Hydrology and Erosion -- Altitudinal Migrations and Changes in the Composition of High Mountain Plant Communities -- Altitudinal Migrations and Changes in the Composition of Animal Communities -- Dynamics of Forest Systems Under Land Use and Climatic Change Scenarios -- Resilience of Montane Ecosystems to Major Disturbances (fires) -- Migrations Rivers -- High Mountain Lakes as Remote Sensors of Global Change -- Paleolimnological Indicators of Climate Change -- Atmospheric Inputs and Drastic Alterations in Food Webs and Ecosystems Processes -- Remote Sensors Monitoring of Functional Aspects of Terrestrial and Aquatic Ecosystems -- Managing the Uniqueness of Sierra Nevada Ecosystems Under Global Change: Adaptive Projects -- Incorporation of Traditional Knowledge in Agrobiodiversity for a Sustainable Mountain Economy -- Data Model, E-infrastructure Services and Virtual Research Environments (VRE) -- Advancing Open Science in Sierra Nevada: Current Citizen Science Campaigns -- Filling the Gaps in Research, Management and Social Connection.
    Abstract: This book covers the landscape, geography and environment of the Sierra Nevada in Spain. The Sierra Nevada hosted the last glaciers in southern Europe. Today, it is one of the most important centers of plant diversity in the western Mediterranean and one of the most outstanding in Europe. This massif has ideal conditions to analyze past environments as well as the effects of global change on ecosystems. This can be seen in the large number of projects that are being conducted within the umbrella of the Sierra Nevada Global Change Observatory. This book summarizes all the scientific knowledge available about this massif, from the geomorphological and ecological perspectives to the recent spatial adaptive management and Open Science initiatives. Focusing on the very sensitive mountain environment of Sierra Nevada, the book intends to be a reference for many people interested in mountain processes. The audience would include scientists from all disciplines, but it would also target on an audience beyond the academia (territorial managers, environmentalists, mountaineers, politicians, technicians, etc.).
    Type of Medium: Online Resource
    Pages: XVII, 421 p. 171 illus., 156 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030942199
    DDC: 910
    Language: English
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    Keywords: Geography. ; Teaching. ; Human geography. ; Critical Thinking. ; Geography. ; Pedagogy. ; Human Geography. ; Critical Thinking.
    Description / Table of Contents: Chapter 1-The wonderment of touching, sensing and naming the more-than human world -- Chapter 2-Being in and through aesthetic forms of expressions reimagining a future world -- Chapter 3-Awareness and subjectification of the more-than-human world -- Chapter 4-Exploring the world in sensuous ways, creating new narratives and asking urgent and severe questions -- Chapter 5-Social Justice and Action Competences in Classroom Practice: The future ‘skills’ of citizenship -- Chapter 6-Introducing disorienting dilemmas: Provoking actions -- Chapter 7-Creating spaces for negotiation, imagining and listening: Stretching situated moments of critical literacy in whole class discussion -- Chapter 8-Addressing anxiety: To linger, confirm and give hope -- Chapter 9-Transformative learning: Creating new identities -- Chapter 10-Take a stance: Facilitating students’ decision-making.
    Abstract: This volume focuses on the fourth Sustainable Development Goal (SDG), education, to look at sustainability from various angles with the purpose of challenging preconceptions about what sustainable education might entail and how it should be conducted. To this end, the book assembles scholars from various research fields and disciplines, who are willing to be at the cutting edge regarding sustainability and education on all levels with students in the ages of 6-15. Through this approach, the text points towards a “wild pedagogy” in line with post-sustainable thinking. This involves agency and the role of nature itself as a co-educator, and promotes cultural changes, and explorative processes of finding “the wild” – the unknown, and complexity in nature – and thus of challenging the human need for control. This approach is also, in line with the 2030 Agenda, an attempt to move from advocating predetermined behavioural change to embracing a pluralistic perspective on sustainability, based on holistic views on education. Such views include curiosity, wonderment, compassion and agency as guiding lights. The book is structured into three sections, based on three interrelated strands. These strands are, in various ways, dependent on one another and further engaged with bringing education theory and practice together. These strands are 1) Belonging and sensing, 2) Critical thinking, social justice and action competence, and 3) Creating hope in a vanishing world. These strands aim to increase our access to and understanding of the ways in which sustainability can be integrated into education and why. The purpose of the text is to encourage educators of all kinds and levels, as well as scholars in different fields, to explore new perspectives on education for sustainable development. The book examines probes in diverse academic fields and focuses on how to combine different approaches and content, and therefore everyone interested in interdisciplinary and cross-curricular teaching and learning should find this work enlightening. .
    Type of Medium: Online Resource
    Pages: XXVII, 186 p. 42 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030845100
    Series Statement: Sustainable Development Goals Series,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Medical care. ; Human geography. ; Integrated Geography. ; Health Care. ; Human Geography.
    Description / Table of Contents: 1-Adolescent Mental Health in the MENA Region and the link with Policy and Programming -- 2-There is no Health Without Mental Health: The Middle East and North Africa -- 3-A Silent Epidemic of Depression among Adolescents in the Middle East and North Africa Region: Emerging Tribulation -- 4-Understanding mental illness stigma in Arab youths’ everyday lives -- 5-Developing and Implementing Youth Friendly Public Policies: A perspective into the Arab Region -- 6-Adolescent health in Saudi Arabia: Policy dimensions -- 7-Health Policies of Adolescents in the Middle East and North Africa: What Works, What Doesn’t, and How Do We Strategize in the Age COVID-19?.
    Abstract: This 2-volume set focuses on adolescent health in the Middle East and North Africa region (MENA), and presents the latest research on the health risk behaviours and social behaviours that adolescents from the MENA region engage in. While there has been a surge in peer-reviewed research publications on population health in the MENA region in the last couple of decades, very few books offer a resource to address the diverse negative influences that disproportionately affect adolescents and children in the MENA region, including increased tobacco consumption culture, low emphasis on physical activity, increased sedentary behaviours, weak health policies, and societal issues related to displacement and political conflicts. These books offer a synthesis of current knowledge on adolescent health issues in the MENA region, and aim to provide evidence-informed adolescent health care practices that address current issues related to mental, physical, reproductive and nutritional health. Volume 1 focuses on mental health in the MENA region, the development and implementation of youth friendly public policies, and how to strategize in the age of COVID-19. The study will aid health care professionals, policy makers, government organizations and health program planners to assess current policies and practices related to adolescent health in the MENA region, and to identify the best courses of action moving forward. .
    Type of Medium: Online Resource
    Pages: X, 121 p. 5 illus., 3 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030917906
    Series Statement: Global Perspectives on Health Geography,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Sustainable architecture. ; Urban ecology (Biology). ; Buildings Design and construction. ; Restoration Ecology. ; Geography. ; Sustainable Architecture/Green Buildings. ; Urban Ecology. ; Building Construction and Design. ; Restoration Ecology.
    Description / Table of Contents: Chapter 1 -- Study on Mechanism of Climate Response and Ecological Restoration in High Density Urban Area. Chapter 2 -- Ecological Process and Security under the Intensification of Urban Agglomeration Development. Chapter 3 -- Seoul Botanic Park, Inventing New Type of Sustainable Park. Chapter 4 -- Ecological Restoration Design Integrated with City Life. Chapter 5 -- Solar Power Singapore. Chapter 6 -- Research on Practical Application of Healthy Building in South China. Chapter 7 -- Performance-based Evaluation on Biophilic Design Qualities of Outdoor Spaces: BUCEA Campus as a Case Study. Chapter 8 -- Current Status of Artificial Intelligence in Smart Home – From Literature and Product. Chapter 9 -- Consideration of Sustainable Design. Chapter 10 -- Automatic Generation of 3D House Models with Solar Photovoltaic Generation. Chapter 11 -- Performance-driven Design Methods of Building Shape: Investigations based on Acoustics and Daylight. Chapter 12 -- Design and Climate-Responsiveness Performance Evaluation of an Integrated Envelope for Modular Prefabricated Buildings. Chapter 13 -- Meso-scale Urban Environmental Performance Evaluation in High Density Urban Context. Chapter 14 -- The Passive in Singapore: Revolution of Green Building Rating System.
    Abstract: This volume discusses the climate responsiveness of sustainable architecture design and technology in China, Japan, Singapore, and South Korea in recent years, addressing concepts and applications in urban planning, building design, and structural performance evaluation. The four sections of the text cover the theory and implementation of sustainable architecture within various geographic boundaries and contexts, offering an interdisciplinary assessment of the challenges faced in urban areas at different climate zones. The main topics covered are: 1) urban ecological restoration under the influence of climate environment; 2) health and human considerations of building and environment; 3) prototype optimization of sustainable building, and 4) feedback of building performance and design evaluation. The book is intended to be a contribution to the growing body of knowledge on sustainable architecture for applicable use by practitioners, city planners, field researchers, and building operators in building design, construction, usage, operation, and maintenance.
    Type of Medium: Online Resource
    Pages: VIII, 245 p. 113 illus., 83 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030800345
    Series Statement: Spatial Planning and Sustainable Development,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Landscape architecture. ; Landscape ecology. ; Urban ecology (Biology). ; Geography. ; Landscape Architecture. ; Landscape Ecology. ; Urban Ecology.
    Description / Table of Contents: Chapter1. Introduction and Methodology -- Chapter2. Ancient Indian Design and Town Planning Principles as a Frame for Case Studies -- Chapter3. Other Interpretive Frameworks -- Chapter4. Shiva Temples -- Chapter5. Deliberations.
    Abstract: Classic Indian texts and Vaastupurusha Mandala are not often discussed in the western discourse on urbanism, even while much of these predate the commonly taught European writings. This book sheds light on some of those forgotten concepts, thus making the lesser discussed classic Indian town organization ideas accessible to architecture, landscape, and urban planning students worldwide. The resonance of these concepts in present times are reviewed through case studies of select Hindu temple towns in India. Furthermore, the author underscores the formal abstraction of the classic Indian Mandala and transplants the discourse from sociology to socio-ecologically adept trans-disciplinary design thinking. The creative interpretations offer a premise to start revising classic models for current practice to influence the urbanism and ecology of a place in accordance with the changing climate. Reviews “India has a strongly developed design, planning language and principles or sutras as shared through ancient Indian texts approximately developed through 5000-550 BCE such as, Kamikagama and Suprabhedgama, Matsyapurana, Bhavishyapurana, and Manasara. Kautilyashastra from around 5th BCE builds additional layers of complexity to the discourse. Sharma’s book orients the students to some of these classic ancient principles while taking them on an investigative journey of applicability of these at temple precinct and town level.” - Pankaj Jain. Professor and Head of the Department of Humanities and Languages, FLAME University, Pune, India “Our changing climate is forcing the rapid evolution of the pressing issues concerning urbanism. Sharma’s book draws upon traditional Indian frameworks to be embedded in design methods, to creatively mitigate the current problems to be addressed in urbanism.” -Tom Verebes. Professor of Architecture, New York Institute of Technology "Dr. Sharma presents an enlightening and groundbreaking perspective on the Hindu Temple landscape, placing it in the nexus of urbanism and ecology." - Diane Jones Allen, Professor of Landscape Architecture, University of Texas at Arlington.
    Type of Medium: Online Resource
    Pages: XIII, 112 p. 106 illus., 55 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030872854
    DDC: 910
    Language: English
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    Keywords: Environmental geography. ; Urban ecology (Biology). ; Sustainable architecture. ; Landscape architecture. ; Landscape ecology. ; Integrated Geography. ; Urban Ecology. ; Sustainable Architecture/Green Buildings. ; Landscape Architecture. ; Landscape Ecology.
    Description / Table of Contents: Part I. The Green City: General Concept -- Chapter 1. What Does “The Green City” Mean?(Jürgen Breuste) -- Chapter 2. What Is Urban Nature? (Jürgen Breuste) -- Chapter 3. What is Urban Green and Blue Infrastructure? (Jürgen Breuste) -- Chapter 4. The Green City: General Concept (Jürgen Breuste) -- Part II. The Nature Concept – of What Urban Green Nature Consists of Part Front Matter -- Chapter 5. The Four Urban Natures Approach (Jürgen Breuste) -- Chapter 6. Urban Woodlands - Remnants of Pristine Landscape (Jürgen Breuste) -- Chapter 7. Public Urban Parks - Designed Urban Green Spaces (Jürgen Breuste) -- Chapter 8. Urban Gardens – The Private Urban Green (Jürgen Breuste) -- Chapter 9. Urban Waters – The Urban Blue Infrastructure (Jürgen Breuste) -- Chapter 10. New Urban Wildernesses - Novel Urban Ecosystems (Jürgen Breuste).
    Abstract: This book shows what role nature can play in a city and how this can make it a better place for people to live. People, planners, designers and politicians are working towards the development of green cities. Some cities are already promoted as green cities, while others are on their way to become one. But their goals are often unclear and can include different facets. Presenting contributions from world leading researchers in the field of urban ecology, the editors provide an interdisciplinary overview of best practices and challenges in creating green cities. They show examples of how to build up these cities from bits and pieces to districts and urban extensions. Each example concludes with a summary of the collected knowledge, the learning points and how this can be used in other places. The best practices are collected from around the world – Europe, America and Asia. Contributions cover a wide range of biophysical and cultural backgrounds within these three continents, including the Central, Southern and Eastern European region, as well as Latin and North America. The new dynamic urban development of Asia is illustrated by case studies from China and the Indian subcontinent. The reader will learn which role nature can play in green cities and what the basic requirements are in terms of culture, pre-existing nature conditions, existing urban surroundings, history, design and planning.
    Type of Medium: Online Resource
    Pages: XX, 595 p. 201 illus., 171 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783030730895
    Series Statement: Cities and Nature,
    DDC: 910
    Language: English
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    Keywords: Geography. ; Geography.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Framework -- Chapter 3. Case study -- Chapter 4. Discussion -- Chapter 5. Conclusions -- Appendices.
    Abstract: This book provides a multidisciplinary approach for the study of the “abandonment” problem at the inter-section among urban studies, neo-institutionalist perspectives, and social ontology. An analytical framework (based on descriptive and operational issues, factors, reasons, policies) has been built to interpret the phenomenon of abandonment and possible ways of intervening. The work considers the Italian situation in general terms and examines the case study of Milan in depth. This case is interesting because it triggered public discussions on the problem of abandonment in a non-shrinking context. Moreover, recently, specific policies to cope with abandonment problem have been introduced. The purpose of the book is to show that the problem of the “abandonment” of urban buildings should be understood as a social fact and not as a brute fact. Thus, in this work the “abandoned” state of buildings is considered as not directly related to certain physical variables; rather, it entirely depends on human evaluations. Crucial information in this regard is how institutional frameworks (e.g. sets of rules of conduct) influence individual behaviour and actions through time. In this view, we may identify abandonment as a phenomenon intertwined with the actions of both private and public entities. The neo-institutional approach helps to highlight how the problem of abandonment is articulated with respect to property rights, formal constraints, reasons behind policy decisions, intervention strategies and implementations.
    Type of Medium: Online Resource
    Pages: VI, 89 p. 19 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030903671
    Series Statement: SpringerBriefs in Geography,
    DDC: 910
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Architecture. ; Materials science. ; Bioclimatology. ; Climatology. ; Geography. ; Architecture. ; Materials Science. ; Climate Change Ecology. ; Climate Sciences.
    Description / Table of Contents: Introduction -- Chapter 1. BauKlima/ BuildingClimate -- Chapter 2. BauStoff/ Building Matters -- Chapter 3. KlimaStoff/ (Future) Climate Matters -- Bibliography.
    Abstract: This book examines prospective climate adaptive building materials in desert and drylands in the context of climate change, desertification, urbanisation demands, and the consequent sustainable urban development challenges. This preliminary collection of ecological materials covers the characterisation of biotic and abiotic resources for materials, their specifications and benefits for adequate bio-climatic design and construction. Particular emphasis is given to ecological composite materials for advances in desert architecture. Based on the initial collection, the book culminates with potentials for new ecological building materials. The "eComposite Combinator" matrix offers potential research recipes and encourages the reader to conduct further climate-matters related research.
    Type of Medium: Online Resource
    Pages: XIII, 134 p. 26 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030954567
    Series Statement: SpringerBriefs in Geography,
    DDC: 910
    Language: English
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  • 76
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Cities and towns History. ; Sociology, Urban. ; Political science. ; Geography. ; Urban History. ; Urban Sociology. ; Political Science.
    Description / Table of Contents: Introduction: Critical planning and design: Walking through roots and dissenting imaginations -- Part 1: Roots -- Giancarlo Paba’s trilogy of Luoghi comuni (Common Places, 1998), Movimenti urbani (Urban Movements, 2003), Corpi urbani (Urban Bodies, 2010): Influential Italian ‘critical planning’ thinking -- Ildefonso Cerdà, Teoría General de la Urbanización, 1867: An innovative approach -- L’Ordine politico della Comunità (The Political Order of Community) 2014: Concrete community and territorial principle in Adriano Olivetti’s thought -- All the layers of an ecological commitment at the frontier: Ian McHarg, Design with Nature, 1969 -- L' Architecture de survie (1978) is back talking to EU cities in crisis: The provocative message by Yona Friedman as a key for the present and future urban agenda -- Part 2: Planning pathways -- John Friedmann, The Good Society (1979): Panning pathways for a just society -- David Harvey’s Urbanization of Capital (1985): Why it helped me so much -- A place in the world? Places, Cultures and Globalization, 1995. Doreen Massey’s lessons: Is the world really shrinking or is the geography of the world teaching us openness and diversity? -- Patsy Healey and Collaborative Planning (2005): Re-thinking democracy in the ‘reasoning in public’ arena -- Utopian tension: Sandercock’s inspiring journey “Towards Cosmopolis” (1998) -- Zwischenstadt / Inbetween city. Thomas Sieverts, Cities Without Cities: An interpretation of the Zwischenstadt, 2004 -- Part 3: Conceptual frames -- Inquiry and change: The troubled attempt to understand and shape society, 1990: The radical contribution of Charles E. Lindblom’s self-guiding society and probing volitions -- Rediscussing Robert Nozick’s Anarchy, State and Utopia, 1974 -- Property titles to land and issues of distributive justice -- Blade Runner, 1982. Do Androids dream of electric sheep?- Philip K Dick’s science fiction and Maschinenmenschen in Metropolis -- Max Weber, Die Stadt (1922), English edition, Max Weber, The City, edited and traslated by Don Martindale and Gertrude Neuwirth, The Free Press, 1958 -- Antonio Gramsci and the prison notebooks -- Le droit à la ville, 1968: Reading Lefebvre’s the right to the city in planning perspective -- The trouble with Henri: The production of urban space – from theory to research -- Gilles Deleuze & Félix Guattari, Mille Plateaux, 1980: "The good use of philosophy" -- Georges Didi-Huberman, La survivance des lucioles (2009). The thickness of time: going beyond the surface of the present to understand contemporary territories.
    Abstract: The book interprets and recombines, within a subjective trajectory, some roots, pathways and conceptual frames of the planning thought that worked either as dissenting imaginations or generative source to critically question the modernist epistemologies. ‘Critical planning and design’ is presented in this book as a field of research inspired by critical urban theory and developed along with ideas and theories that prove to be radical, alternative, dialectical to the mainstream history of planning. In this book, scholars present what they consider as the most important books in the field of planning, public policy and design. They have been asked to write about a book and its author, in their preferred manner. This freedom allowed passionate and original contributions. Three main threads - the three parts of the book - shape the choices of the authors. The first concerns the reconstruction of some genealogical roots of planning (including Cerdà, Yona Friedman, Alberto Magnaghi, and Ian McHarg). The second thread groups the authors who dialogue with contemporary protagonists of the planning debate (including John Friedmann, Leonie Sandercock, Doreen Massey, David Harvey, Tom Sievert, and Patzy Healey). The third thread includes authors who dig into relevant writings in social and philosophical sciences (including Max Weber, Charles Lindblom, Henri Lefebvre, Gilles Deleuze & Félix Guattari, Georges Didi-Huberman, Robert Nozick, Pand hilip K Dick). The book is addressed to researchers of planning and urban studies, who value the critical re-reading of some fundamental books. Including thoughtful and critical arguments on influential thinkers of the past two centuries, the book will enable students, scholars and researchers of planning, design, political science, geographical, environmental, and urban studies to better understand the socio-spatial and ecological transformations under the contemporary transition while relying on a “usable past”. The book is also addressed to a wider audience of readers interested in the problems of the city and space.
    Type of Medium: Online Resource
    Pages: XX, 263 p. 8 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030931070
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 77
    Keywords: Geography. ; Earth sciences. ; Geography. ; Earth Sciences.
    Description / Table of Contents: 1 Challenging a static conception of Heimat -- 2 Heimat: theoretical framework(s) -- 3 Methodological approach -- 4 Insights from migrant biographies on the concept of Heimat -- 5 Heimat: an emotional map of biographical references -- 6 Conclusions on Heimat in the context of international migration.
    Abstract: The German notion of ‘Heimat’ is highly subjective, ambiguous and historically charged. Senses of belonging and identity associated with Heimat render the concept vulnerable to appropriation and instrumentalization by different political forces. Thereby, a static and exclusive understanding of Heimat is often depicted. This book drafts a counternarrative to demystify the contested concept. On the one hand, Heimat is conceptualized as spatial through emotional-geographical approaches to human-place relations. And on the other hand, the concept is placed in a global context through the perspective of international migration. The author contributes to the understanding of Heimat as an emotional map of self-location. This subjective map is neither purely static nor dynamic - it is characterized by simultaneities of opposing processes. About the Author Jessica Andel is currently enrolled in the Master’s programme “Human Geography: Globalisation, Media and Culture”. Since November 2019, she has been working as a student assistant on the Human Geography-team at the Institute of Geography of Johannes Gutenberg University.
    Type of Medium: Online Resource
    Pages: VI, 113 p. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783658389857
    Series Statement: BestMasters,
    DDC: 910
    Language: English
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  • 78
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Social sciences. ; Humanities. ; Veterinary medicine. ; Human geography. ; Cultural geography. ; Geography. ; Humanities and Social Sciences. ; Veterinary Science. ; Social and Cultural Geography.
    Description / Table of Contents: Chapter 1. Introduction: Roald Amundsen and the Sled Dogs -- Part 1: Hobart, Australia -- Chapter 2. All Aboard: The Departure from Antarctica -- Chapter 3. Leaving Antarctica: The Rough Journey Back -- Chapter 4. The Public Relations Machine Behind the Scenes -- Chapter 5. A Hero’s Welcome in Hobart -- Chapter 6. Fleeing the Journalists Whilst Courting the Press -- Chapter 7. Twenty-One Sledge Dogs for Douglas Mawson -- Chapter 8. A Tale of Two Fates: Roald Amundsen’s Victory and Robert Falcon Scott’s Tragedy -- Part 2: Buenos Aires, Argentina -- Chapter 9. The Captain and Mrs. Snuppesen -- Chapter 10. Arrivals and Departures: Buenos Aires, Norway, and Don Pedro Christophersen -- Chapter 11. The Dogs at the Buenos Aires Zoological Gardens -- Chapter 12. London Calling: Lord Curzon and the Royal Geographical Society -- Chapter 13. The Big Speech: The Cheer for the Dogs -- Chapter 14. Death and Deceit.
    Abstract: This book documents the return of the surviving sled dogs of the Norwegian Antarctic Expedition of 1910–1912 from Antarctica, where they had helped Roald Amundsen become the first human to reach the South Pole. This book is the sequel to the highly acclaimed Roald Amundsen’s Sled Dogs: The Sledge Dogs Who Helped Discover the South Pole. It chronicles how the sled dogs were used internationally to further promote the expedition’s great achievement and follows some of the dogs as they undertake subsequent expeditions – with Douglas Mawson’s Australasian Antarctic Expedition of 1911–1914, which made scientific discoveries, and with Arve Staxrud’s Norwegian Arctic Rescue Mission of 1913, which saved members of the Herbert Schröder-Stranz German Arctic Expedition. The book tracks the remaining 39 sled dogs to their next challenging adventures and their final destinations in Argentina, Norway, Antarctica, and Australia. Like its predecessor, the book portrays how Amundsen continued to utilize the Polar dogs – both in their lives and in their deaths – to propel his career and solidify his expedition's image.
    Type of Medium: Online Resource
    Pages: XXV, 467 p. 89 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030651138
    DDC: 910
    Language: English
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  • 79
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Urban policy. ; Climatology. ; Integrated Geography. ; Urban Policy. ; Climate Sciences.
    Description / Table of Contents: Governance of climate responsive cities: Scale matters!- Resilience, uncertainty and adaptive planning -- Barriers to implementing local climate action plans in Turkey: Searching for a potential way-out -- Exploring the Governance of Naples, Italy, through a climate responsive approach -- Community engagement in climate change policy: The case of three mills, East London -- Co-design of a nature-based solutions ecosystem for reactivating a peri-urban district in Quito, Ecuador -- How co-design of public space contributes to strengthening resilience: Lessons from two Chilean cases -- In-formal green infrastructure (IGI) and the pursuit of climate responsive environments in Quito City -- Co-designing local climate action: A methodological framework from a democratic perspective.
    Abstract: The book presents governance with a particular focus on the social and spatial aspects of climate responsiveness and reads the practice of governance across different scales. It conceptualizes a framework of scale composed of three main categories including (i) scientific knowledge, (ii) plans and policies, and (iii) authorities of action. This framework presents ‘practice’ as the social context in which these three can interplay adaptively. Within this framework, the book presents case studies from Turkey, Italy, Ecuador, Chile and the UK, that reach meaningful planning and design solutions at national, city, and neighbourhood scales in the face of climate change. It offers implementation clues that are transferable to ever-increasing climate action around the globe. The book will be of interest to both professionals and scholars involved in urban design, urban planning and architecture, especially those in the field of climate responsive urbanism. It will also be a valuable resource for non-governmental organizations and social enterprises dealing with sustainability and climate change policies.
    Type of Medium: Online Resource
    Pages: XIII, 164 p. 37 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030733995
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 80
    Keywords: Geography. ; Economic geography. ; International relations. ; Geography. ; Economic Geography. ; International Relations Theory.
    Description / Table of Contents: Introduction -- Framing the double transition and the international intervention -- The division and destruction of Sarajevo -- The consolidation of the division after the war -- The struggle to rebuild ethnic diversity in Sarajevo -- The incomplete economic transition -- The urban spatial reconfiguration of Sarajevo -- The ethnic reconfiguration in the urban area of Sarajevo -- Conclusions.
    Abstract: Following the signing of the peace agreement and the end of three-and-a-half years of siege, Sarajevo simultaneously experienced a double transition, from war to peace and from socialism to capitalism, that was marked by an increasing international intervention. This book presents a study of the urban transformation of Sarajevo during the post-war period and considers both the role and the impact of the international community in its spatial and ethnic configuration. Part I focuses on the period of maximum international involvement developed at local level, from December 1995 until 2003, and comprises chapters on the ethno-territorial division of the city, the reconstruction of its ethnic diversity and the liberal transition fostered and imposed internationally. Part II deals with the impact of these policies on the current spatial, functional and ethnic configuration in the area of Sarajevo.
    Type of Medium: Online Resource
    Pages: XVII, 136 p. 10 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030805753
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 81
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geography. ; Sociology, Urban. ; Regional economics. ; Spatial economics. ; Cities and towns History. ; Geography. ; Urban Sociology. ; Regional and Spatial Economics. ; Urban History.
    Description / Table of Contents: Introduction -- The natural city -- Additional theoretical lenses to understand the city -- Historical notes on Tirana -- Tirana patterns at a glance -- Holistic approach to Tirana pattern analysis -- Methodology for holistic understanding of the urban patterns -- Conclusions.
    Abstract: The ideas presented in this book are a conceptual leverage to correct the rigidity of top-down practices and bring the real city, or the city of everyday life, closer to the city of conventional planning. Considering self-organization as the starting point at the base of complex systems, this book tries to understand how specific qualities emerge and evolve from this behavior. For this, the book discusses new ways of looking at and understanding cities by applying holistic methods and approaches based on the conceptual grounds of quantum, fractal, and complexity theories. The book highlights the fact that the information on how to transform and build a city is contained within the city itself. In this regard, some methodological steps to unpack complexities and translate the essential qualities of space into potential generators for city design and planning are provided. The book urges courageous experimentation and proposes a methodology where the computational nature of urban phenomena goes along with historic anthropological ideas, thus emphasizing the characteristics of a specific reality in a model. They do not exclude each other; in fact, they are part of the unbroken web of wholeness. Importantly, the proposed methodology supports gradual and natural coevolution process in the city through combining planned and unplanned actions and the involving multiplicity of actors, impacting on Urban Planning and Design Practice.
    Type of Medium: Online Resource
    Pages: IX, 262 p. 135 illus., 103 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030827311
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 82
    Keywords: Environmental geography. ; Natural disasters. ; Human ecology Study and teaching. ; Architecture History. ; Cultural property. ; Human geography. ; Cultural geography. ; Integrated Geography. ; Natural Hazards. ; Environmental Studies. ; Architectural History and Theory. ; Cultural Heritage. ; Social and Cultural Geography.
    Description / Table of Contents: Introduction -- Part I: Heritage and collective memory for resilience and reconstruction -- Thinking about post-disaster reconstruction in Europe: Functionalist and identity approaches -- Old Souks of Aleppo: A narrative approach to post-conflict heritage reconstruction -- Photography for the city, between the need for protection, conservation and civic identity -- Cultural heritage as stones of memory: The recovery of archives in the area of the Marche crater -- Intangible heritage and resilience in managing disaster shelters: Case study in Japan -- Water gives, water takes away. Memory, agency and resilience in ENSO-vulnerable historic landscapes in Peru -- Intangible cultural economy, a mould for tangible urban built fabric – The case of Shahjahanabad, India -- The Tree: The concept of place after the earthquake, L’Aquila -- Part II: Historic and contemporary reconstructions of historic cities -- Marsica: One hundred years on -- Coventry: Shell or Phoenix, city of tomorrow or concrete jumble? From reconstruction to the Phoenix Initiative, UK -- Post-trauma recovery of monumental buildings in Italy and the United States at the beginning of twentieth century -- Historical town centres and post-seismic reconstructions: Between functional recovery and heritage value awareness -- Integrating green solutions into post-earthquake recovery of Bam, Iran -- Reconstruction of heritage and spirit: Mending the scars of Aleppo -- Beyond the damage, the reconstruction of L’Aguila -- The “Solidere” effect and the localisation of heritage reconstruction in post-war transitions, Libya -- Bell towers under (seismic) attack: Saving a symbol, once it became a menace -- Ancient city of the future: Notes on the reconstruction of Beirut -- Part III: Society, governance and collective resilience -- Bonding between urban fabric and capacity of collective resilience: The case of Talca historic centre, Chile -- Multi-perspective pre-disaster examination as post-disaster managerial thinking ahead for Hoi An in Vietnam -- Play Street: Experimenting tactical urbanism for urban resilience in Iran -- The preservation of rural landscapes for building resilience in small towns: Insights from north Italy -- Antigua Guatemala, from history of disasters to resilient future -- Emergency management for the built heritage post-earthquake: Emilia-Romagna and Lombardy, Italy -- Factors of educational poverty and resilience responses in L’Aquila’s young population -- Dropout, resilience and cultural heritage: A focus of the ACCESS Project in a highly fragile area -- How can teachers promote resilience in schools?- Part IV: Bringing the 21st century into reconstruction -- Cities in transformation: Smarter reconstruction in historic city centres -- Evaluating visitors’ experiences at St Augustine’s Abbey (Canterbury) -- Seismic Microzonation: A preventive measure for the conservation of the built heritage -- The representation of a resilient city: The case of Amatrice’s reconstruction -- Evacuation simulation considering tourists’ attempts to return home: A case of the Kiyomizu-dera Temple area, Japan -- Public administration versus social media in emergency situations -- Social media and disaster management in Iran: Lorestan floods as case study -- Environmental issues and energy potentials in post-earthquake reconstruction -- A multidisciplinary approach to retrofitting historic buildings: The case of the former San Salvatore Hospital, L’Aquila.
    Abstract: This book examines reconstruction and resilience of historic cities and societies from multiple disciplinary and complementary perspectives and, by doing so, it helps researchers and practitioners alike, among them reconstruction managers, urban governance and professionals. The book builds on carefully selected and updated papers accepted for the 2019 Silk Cities international conference on ‘reconstruction, recovery and resilience of historic cities and societies’, the third Silk Cities conference held in L’Aquila, Italy, 10-12 July 2019, working with University of L’Aquila and UCL. This multi-scale, and multidisciplinary book offers cross-sectoral and complimentary voices from multiple stakeholders, including academia, urban governance, NGOs and local populations. It examines post-disaster reconstruction strategies and case studies from Europe, Asia and Latin America that provide a valuable collection for anyone who would like to get a global overview on the subject matter. It thereby enables a deeper understanding of challenges, opportunities and approaches in dealing with historic cities facing disasters at various geographical scales. Additionally, it brings together historical approaches to the reconstruction of historical cities and those of more recent times. Thus, it can be used as a reference book for global understanding of the subject matter.
    Type of Medium: Online Resource
    Pages: XVI, 666 p. 238 illus., 204 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030773564
    Series Statement: The Urban Book Series,
    DDC: 910
    Language: English
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  • 83
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Environmental geography. ; Climatology. ; Environmental health. ; Human geography. ; Environmental management. ; Integrated Geography. ; Climate Sciences. ; Environmental Health. ; Human Geography. ; Environmental Management.
    Description / Table of Contents: I. Introductory -- 1. Introduction: Extreme Weather and Human Health: Global Perspective -- 2. Dust Storms and Human Health -- 3. The Impacts of Climate Change on Health and Development in Canadian Arctic and Sub-Arctic Communities in the 21st Century: A Systematic Review -- 4. Wildland Fire, Extreme Weather, and Society: Implications of a History of Fire Suppression in California, USA -- 5. Extreme Weather Events, Health and Development.
    Abstract: This edited book assesses the impacts of various extreme weather events on human health and development from a global perspective, and includes several case studies in various geographical regions around the globe. Covering all continents, it describes the impact of extreme weather conditions such as flash floods, heatwaves, cold waves, droughts, forest fires, strong winds and storms in both developing and developed countries. The contributing authors also investigate the spread of diseases and the risk to food security caused by drought and flooding. Further, the book discusses the economic damage resulting from natural disasters including hurricanes. It has been estimated that in 2017 natural disasters and climate change resulted in economic losses of 309 billion US dollars. Scientists also predict that if nothing is done to curb the effects of climate change, in Europe the death toll due to weather disasters could rise 50-fold by the end of the 21st century, with extreme heat alone causing more than 150,000 deaths a year, as the report on global warming of 1.5°C warns that China, Russia and Canada’s current climate policies would steer the world above a catastrophic 5°C of warming by the end of 2100. As such, the book highlights how the wellbeing of different populations is threatened by extreme events now and in the foreseeable future.
    Type of Medium: Online Resource
    Pages: XVIII, 382 p. 83 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030237738
    DDC: 910
    Language: English
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  • 84
    Keywords: Cancer. ; Medical microbiology. ; Cytology. ; Pediatrics. ; Cancer Biology. ; Medical Microbiology. ; Cell Biology. ; Pediatrics.
    Description / Table of Contents: Adjuvant and Neoadjuvant Chemotherapy for Osteosarcoma: A Historical Perspective -- Part 1: Surgical Considerations and Outcomes -- Limb Salvage and Reconstruction Options in Osteosarcoma -- Advances in the functional assessment of patients with sarcoma -- Part II: Novel Therapeutic Approaches Based on Biology -- Radiopharmaceuticals for Treatment of Osteosarcoma -- HER-2 Targeted Therapy in Osteosarcoma -- Aerosolized Chemotherapy for Osteosarcoma -- The Histone Deacetylase inhibitor Entinostat/Syndax 275 in Osteosarcoma -- Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease -- Using liquid biopsy in the treatment of patient with osteosarcoma -- Part III: Novel Immunotherapeutic Approaches -- Genetically modified T-cell therapy for osteosarcoma: into the roaring 2020’s -- Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Natural Killer Cell Immunotherapy for Osteosarcoma -- Nanocapsule delivery of IL-12 -- Discovery of cell surface vimentin (CSV) as a sarcoma target and development of CSV-targeted IL-12 immune therapy -- Part IV: Survivorship and Late Effects -- Editorial Comments on late effects -- Anthracycline-Induced Cardiotoxicity: Causes, mechanisms & prevention -- Exercise and Physical Activity in Patients with Osteosarcoma and Survivors -- Index.
    Abstract: This thoroughly revised second edition complied in 2 books is an up-to-date overview of the current clinical advances in sarcoma and osteosarcoma. The new edition features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, these essential volumes also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists focused in sarcoma.
    Type of Medium: Online Resource
    Pages: XIII, 212 p. 24 illus., 17 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030430320
    Series Statement: Advances in Experimental Medicine and Biology, 1257
    DDC: 571.978
    Language: English
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    Keywords: Cancer. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Chemoprevention of Cancer - Past,Present, and Future -- Chapter 2. Resveratrol for Cancer Prevention: Current Gaps and Opportunities -- Chapter 3. Pterostilbene as a Potent Chemopreventive Agent in Cancer -- Chapter 4. Pharmacokinetics and Bioavailability Enhancement of Natural Products -- Chapter 5. Vitamin D Compounds and Cancer Stem Cells in Cancer Prevention -- Chapter 6. Anti-cancer Effects of Silibinin – The Current Status in Cancer Chemoprevention -- Chapter 7. Adjuvant Value of Turmeric Extract (Containing Curcumin) in Colorectal Cancer Management -- Chapter 8. Cancer Prevention by Tea Polyphenols -- Chapter 9. The Chemopreventive Power of Isothiocyanates -- Chapter 10. Xanthohumol and Structurally Related Prenylflavonoids for Cancer Chemoprevention and Control -- Chapter 11. Anthocyanins and Cancer Prevention -- Chapter 12. Grape ChemopreventiveAgents AgainstAngiogenesis and Metastasis -- Chapter 13. Punicagranatum L. Constituents for Cancer Prevention, Chemosensitisation and Therapeutic Treatment -- Chapter 14. Cancer ChemopreventivePotential of Epidermal Growth Factor Receptor Inhibitors from Natural Products -- Chapter 15. Anti-cancer Dynamics of Natural Phytochemical Inhibitors of Cyclin-dependent Kinases -- Chapter 16. Pro-apoptotic Properties of Chemopreventive Agents -- Chapter 17. The Use of Anti-inflammatory Agents for Cancer Chemoprevention -- Chapter 18. Combination Chemoprevention by Targeting the Epigenome -- Chapter 19. Perspective – a positive cocktail effect of the bioactive components in the diet.
    Abstract: This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research. .
    Type of Medium: Online Resource
    Pages: XX, 629 p. 59 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030398552
    DDC: 571.978
    Language: English
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  • 86
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Immunology. ; Biomedical Research.
    Description / Table of Contents: Introduction -- Molecular and cellular functions of CTLA-4 pathway -- Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond -- Discovery of new immune checkpoints: family grows up -- Mechanisms of resistance to checkpoint blockade therapy -- Molecular events behind adverse effects -- Rational discovery of response biomarkers -- Spatiotemporal changes in checkpoint molecule expression -- Functions of checkpoint molecules beyond immune evasion -- Genetic alterations and checkpoint expression -- Regulations on messenger RNA: wires and nodes -- Folded or degraded in endoplasmic reticulum -- Mono- and poly-ubiquitination: tags for fates -- Lysosome as the black hole for checkpoint molecules -- Phosphorylation: a fast switch for checkpoint signalling -- Palmitoylation as a signal for delivery -- Checkpoints under traffic control: from and to organelles -- Exosome and secretion: action on? -- Macromolecules and antibody-based drugs -- Mechanisms inspired targeting peptides -- Small molecular inhibitors -- Therapeutic development of immune checkpoint blockers -- Concluding remarks.
    Abstract: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
    Type of Medium: Online Resource
    Pages: X, 653 p. 105 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811532665
    Series Statement: Advances in Experimental Medicine and Biology, 1248
    DDC: 571.978
    Language: English
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  • 87
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Molecular genetics. ; Proteins . ; Cancer Biology. ; Molecular Genetics. ; Protein Biochemistry.
    Description / Table of Contents: Chapter 1: Overview of histone modification -- Chapter 2: The histone H3 family and its deposition pathways -- Chapter 3: Histone H3K27M Mutation in Brain Tumors -- Chapter 4: Histone Mutations and Bone Cancers -- Chapter 5: Histone H3G34 mutation in brain and bone tumors -- Chapter 6: Epigenetic-targeted treatments for H3K27M-mutant midline gliomas -- Chapter 7: Histone lysine to methionine mutation as anti-cancer drug target.
    Abstract: This book focuses on histone mutations, especially those mutations closely related to cancer. Genetic mutations and epigenetic alterations contribute to the development of a variety of cancers: recent genetic studies have identified e.g. H3K27M and H3G34R/V mutation in over 75% of DIPG cases, H3.3K36M mutation in more than 90% of chondroblastoma cases, and H3G34W/L mutation in over 90% of giant cell tumors of bone. Given the high incidence and tumorigenesis effects of histone H3 mutations, they are also referred to as oncohistones. This book highlights the advances made in the area over the past 10 years, and offers a state-of-the-art summary of epigenetic alternation, gene expression, protein structure, drug discovery, immunotherapy, and mouse modeling of histone H3 mutations in various tumors. Chiefly intended to provide researchers and graduate students with an overall picture of these mutations, it will also be of interest to researchers in basic oncology, clinical oncology, and epigenetics, as well as academics and clinical oncology practitioners.
    Type of Medium: Online Resource
    Pages: VII, 96 p. 17 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811581045
    Series Statement: Advances in Experimental Medicine and Biology, 1283
    DDC: 571.978
    Language: English
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  • 88
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Stem cells. ; Cytology. ; Developmental biology. ; Cancer Stem Cells. ; Cell Biology. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.
    Abstract: This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 41 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173622
    Series Statement: Stem Cell Biology and Regenerative Medicine, 73
    DDC: 571.978
    Language: English
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  • 89
    Keywords: Cancer. ; Medical genetics. ; Pharmaceutical chemistry. ; Bioinformatics. ; Cancer Biology. ; Medical Genetics. ; Pharmaceutics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Phytochemicals in Cancer Chemoprevention: A Brief Perspective -- Chapter 2. Phytochemicals in Modulating Signalling Cascades in Cancer Cells -- Chapter 3. Diverse cancer therapeutic interactions: complexities in cancer management -- Chapter 4. Natural Products as Chemosensitizers for Adjunct Therapy in Cancer Management -- Chapter 5. Dietary phytochemicals as epigenetic modulators in cancer prevention: Emerging research trends, gaps, and future perspectives -- Chapter 6. Modulation of Cancer Cell Metabolism and Microenvironment by Phytochemicals -- Chapter 7. Role of Nutrigenetics and Nutrigenomics in Cancer Chemoprevention -- Chapter 8. Nano-delivery carriers for Enhanced Bioavailability of Antitumor Phytochemicals -- Chapter 9. Biphasic Effects of Phytochemicals and their Relevance to Cancer Therapeutics -- Chapter 10. Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention -- Chapter 11. 3 Dimensional Cell Culture Techniques in Cancer Research -- Chapter 12. Animal Models Systems of Cancer for Preclinical Trials -- Chapter 13. Cancer Chemoprevention by Natural Plant Products and Their Derivatives: Clinical Trials.
    Abstract: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.
    Type of Medium: Online Resource
    Pages: XII, 337 p. 120 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811559990
    DDC: 571.978
    Language: English
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  • 90
    Keywords: Cancer. ; Molecular genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology. ; Cancer Biology. ; Molecular Genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology.
    Description / Table of Contents: Chapter 1. Potential Role of Biomarkers, Biosensors, Technologies and Computational Methods in Early Detection of Gastrointestinal Cancer -- Chapter 2. Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer -- Chapter 3. Development and Evaluation of Biomarkers for Early Detection of Cancer -- Chapter 4. Prognostic Molecular Markers for Gastrointestitinal cancer -- Chapter 5. Metabolic Markers for Early Detection of Gastrointestinal Cancer -- Chapter 6. Current Status of MicroRNA-based Biomarkers for Gastric Cancer -- Chapter 7. Genetic Susceptibility Markers of Gastrointestinal Cancer -- Chapter 8. Approaches For Early Detection Of Gastrointestinal Cancer -- Chapter 9. Biosensors and its Applications for Early Detection of Gastrointestitinal Cancer -- Chapter 10. Application of Nanotechnology in Early Detection of Gastrointestinal Cancer -- Chapter 11. Genetic Marker Identification for the Detection of Early-Onset Gastrointestitinal Cancer Through Genome Wide Association Studies -- Chapter 12. Big Data Analytics to Discover Diagnostics and Therapeutics for Gastrointestitinal Cancer -- Chapter 13. System Biology Approach for Early Prognosis of Gastrointestinal Cancer.
    Abstract: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XXIII, 231 p. 38 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811544316
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    DDC: 571.978
    Language: English
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  • 91
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Hematopoietic system. ; Cytology. ; Cancer Microenvironment. ; Haematopoietic System. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Eosinophils in the tumor microenvironment -- Dendritic cells in the tumor microenvironment -- Resident memory T cells in the tumor microenvironment -- NK cells in the tumor microenvironment -- γδ T cells in tumor microenvironment -- Regulatory T Cells in the Tumor Microenvironment -- The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche) -- Langerhans cells in the tumor microenvironment -- Mast cells in the tumor microenvironment -- B cells in the gastrointestinal tumor microenvironment with a focus on pancreatic cancer: opportunities for precision medicine? -- Microglia in the Brain Tumor Microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include eosinophils, NK cells, γδ T cells, regulatory T Cells, Langerhans cells, hematopoietic stem cells, Mast cells, B cells and Microglia, and more. Taken alongside its companion volumes, Tumor Microenvironment: Hematopoietic Cells – Part B updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 215 p. 26 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030492700
    Series Statement: Advances in Experimental Medicine and Biology, 1273
    DDC: 571.978
    Language: English
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  • 92
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Human physiology. ; Diseases. ; Oncology. ; Regenerative medicine. ; Cancer Biology. ; Human Physiology. ; Diseases. ; Oncology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Chapter 1. Isolation and characterization of extracellular vesicles: classical and modern approaches -- Chapter 2. Characterization and fine structure of exosomes -- Chapter 3. Extracellular vesicles mediate the embryonic-maternal paracrine communication -- Chapter 4. The interplay between oviduct-derived exosomes and cumulus-oocyte complexes -- Chapter 5. The interplay between exosomes and spermatozoa -- Chapter 6. Mesenchymal stem cell-derived exosomes and regenerative medicine -- Chapter 7. Therapeutic Potential of Mesenchymal Stem/Stromal Cell Derived-Exosomes -- Chapter 8. Exosomes in Neurodegenerative Disorders -- Chapter 9. Differential expression of exosomal microRNAs in neurodegenerative diseases -- Chapter 10. Urinary exosomes as a possible source of kidney disease biomarkers -- Chapter 11. Extracellular vesicles as potential therapeutic targets and biomarkers for liver disease -- Chapter 12. Implications of extracellular vesicles in blood protozoan parasitic diseases -- Chapter 13. Cancer cells-derived Exosomes and Metastasis -- Chapter 14. Extracellular vesicles and integrins: partners in cancer progression -- Chapter 15. Exosomes: the crucial element in the prostate cancer -- Chapter 16. Exosomal microRNAs: Potential Biomarkers for Cancer Diagnosis, Treatment Response, and Prognosis -- Chapter 17. Exosomes in drug delivery -- Chapter 18. Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems.
    Abstract: This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes’ role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
    Type of Medium: Online Resource
    Pages: XII, 373 p. 34 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811565991
    DDC: 571.978
    Language: English
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  • 93
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. NMR-Based Metabolomics in Cancer Research -- 2. Capillary Electrophoresis–Mass Spectrometry for Cancer Metabolomics -- 3. Chemical Isotope Labeling LC-MS for Metabolomics -- 4. Single cell metabolomics by mass spectrometry imaging -- 5. Fatty Acid Metabolism and Cancer -- 6. Metabolomics of Gastric Cancer -- 7. HIF-1α metabolic pathways in human cancer -- 8. Regulation of glycolysis in head and neck cancer -- 9. Metabolomics of oral/head and neck cancer -- 10. Ion chromatography with mass spectrometry for metabolomic analysis -- 11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids -- 12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy -- 13. Metabolomics of glioma -- 14. Microbial metabolomics: From methods to translational applications -- 15. Advances in the study of N6-methyladenine in eukaryotes -- 16. NMR Based Metabolomics -- 17. Quantitative analysis of oncometabolite 2-hydroxyglutarate -- 18. Tracer-based Cancer Metabolomic Analysis -- 19. Mass spectrometry-based shotgun lipidomics for cancer research -- 20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics.
    Abstract: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
    Type of Medium: Online Resource
    Pages: XV, 312 p. 80 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030516529
    Series Statement: Advances in Experimental Medicine and Biology, 1280
    DDC: 571.978
    Language: English
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  • 94
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Immunology. ; Cancer Biology. ; Immunology.
    Description / Table of Contents: 1. The role of targeted therapy in multiple myeloma -- 2. Lenalidomide -- 3. Pomalidomide -- 4. Mechanisms driving resistance to proteasome inhibitors bortezomib, carfilzomib and ixazomib in multiple myeloma -- 5. Daratumumab -- 6. Elotuzumab -- 7. Histone deacetylase inhibitors -- 8. Bone targeted therapies -- 9. New targeted therapies for multiple myeloma under clinical investigation.
    Abstract: Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.
    Type of Medium: Online Resource
    Pages: XVII, 154 p. 5 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030734404
    Series Statement: Resistance to Targeted Anti-Cancer Therapeutics, 22
    DDC: 571.978
    Language: English
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  • 95
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Cytology. ; Cancer Biology. ; Immunology. ; Cell Biology.
    Description / Table of Contents: Chapter 1. History of oncotherapies in cancer biology -- Chapter 2. Electrochemical Sensors and Biosensors for the Detection of Cancer Biomarkers and Drugs -- Chapter 3. Cell cycle arrest: An impending therapeutic strategy to curb cancer -- Chapter 4. Apoptotic cell death: important cellular process as chemotherapeutic target -- Chapter 5. Regulatory roles of autophagy in cancer -- Chapter 6. ROS and Oxidative Stress in Cancer: Recent Advances -- Chapter 7. Inflammatory mediators: Potential drug targets in cancer -- Chapter 8. Pharmacologic modulation of the immune response against tumours in the elderly. Chapter 9. Angiogenesis: A Therapeutic Target for Cancer -- Chapter 10. Metastasis: A major driver of cancer pathogenesis -- Chapter 11. Designing Personalized and Innovative Novel Drug Therapies For Cancer Treatment.
    Abstract: This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment. The book then discusses the regulation of various pro-apoptotic and anti-apoptotic proteins via chemotherapeutic drugs. In addition, it examines the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells. It subsequently reviews the role of reactive oxygen (ROS) species during carcinogenesis and during chemotherapy, and the potential of anti-inflammatory routes for the development of new therapeutic modulators. Lastly, it describes therapeutic strategies that target the tumor microenvironment and various angiogenic pathways for the treatment of cancer and to develop personalized medicine. Given its scope, the book is valuable resource for oncologists, cancer researchers, clinicians, and pharmaceutical industry personnel.
    Type of Medium: Online Resource
    Pages: XIII, 228 p. 28 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811575860
    DDC: 571.978
    Language: English
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  • 96
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Cancer Biology. ; Oncology.
    Description / Table of Contents: Role of specific phytochemicals against gastrointestinal malignancies -- Role of phytochemicals on growth and metastasis of GI cancer -- Cancer Stem Cells as Therapeutic Targets for Gastrointestinal cancers -- Phytochemicals plus checkpoint inhibitors in GI cancers -- Crucial role of curcumin on gut microbiota associated with GI cancers -- Cellular and Molecular mechanisms of garlic compounds in common GI cancers -- Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy -- Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer -- Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors -- Therapeutic Efects Of Curcumin Against Colorectal Cancer -- Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes -- Role of Dietary Supplementation of Natural products in the Prevention and Treatment of Liver Diseases -- Emerging Roles of Phytochemicals in Hepatocellular Carcinoma -- Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma -- Index.
    Abstract: Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
    Type of Medium: Online Resource
    Pages: XI, 340 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484057
    DDC: 571.978
    Language: English
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  • 97
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword -- Transcription factor RBPJ as a molecular switch in regulating the Notch response -- Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer -- Notch and endometrial cancer -- Notch and Esophageal Squamous Cell Carcinoma -- Notch signaling and liver cancer -- Notch inHead and Neck Cancer -- Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis -- The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond -- Notch Signaling in Thyroid Cancer -- The Relevance of Notch Signaling in Cancer Progression -- Notch Signaling and the Breast Cancer Microenvironment -- Notch pathway: a journey from notching phenotypes to cancer immunotherapy -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XVII, 228 p. 28 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030550318
    Series Statement: Advances in Experimental Medicine and Biology, 1287
    DDC: 571.978
    Language: English
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  • 98
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Microsystems and MEMS.
    Description / Table of Contents: Chapter 1. Strategies to improve oral delivery of natural anticancer molecules -- Chapter 2. Nanoparticles catalyzing enzymatic reactions: recent developments and future prospects -- Chapter 3. Biogenic silver nanoparticles: A potent therapeutic agent -- Chapter 4. Translational studies of nanofibers-based scaffold for skin and bone tissue regeneration -- Chapter 5. Functional Dendritic Coatings for Biomedical Implants -- Chapter 6. Application of nanotherapeutics for combating human protozoan parasitic infections.
    Abstract: This book illustrates the significance of nanotechnology in the delivery of anticancer and antimicrobial drugs, biomimetic technologies, tissue engineering, sensing, diagnostics, and artificial enzymes. It first briefly discusses the use of nanotechnology for the delivery of anticancer medications, and the concept and applications of catalytically active nanomaterial-based artificial enzymes for sensing and diagnostic applications. It then explores the use of silver nanoparticle-based novel antimicrobials, and comprehensively reviews the role of nanomaterials in developing biomedical implants and tissue engineering applications. Lastly, it offers a detailed description of nanotherapeutics for combating human protozoan parasitic infections. Cutting across the disciplines, this book serves as a guide for researchers and scientists in biotechnology, medical science and material science.
    Type of Medium: Online Resource
    Pages: XIV, 240 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811599200
    DDC: 571.978
    Language: English
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  • 99
    Keywords: Cancer. ; Tumor markers. ; Medical screening. ; Materials. ; Detectors. ; Cancer Biology. ; Tumour Biomarkers. ; Cancer Screening. ; Sensors and biosensors.
    Description / Table of Contents: Chapter 1. An Introduction to Cancer Biomarkers -- Chapter 2. Cervical Cancer -- Chapter 3. Potential Biomarkers for Early Diagnosis of Cervical Cancer -- Chapter 4. Methods for Screening of Cervical Cancer: State of Art -- Chapter 5. Electrochemical DNA Biosensors for Cervical Cancers -- Chapter 6. Optical DNA based Sensors for Cervical Cancers -- Chapter 7. Other Biosensors for Cervical Cancer Detection.
    Abstract: This book highlights both conventional and nanomaterials-based biosensors for the detection of cervical cancers. It describes developments in the selective and sensitive electrochemical biosensors based on DNA for the early diagnosis of cervical cancer. Further, this book covers other nano-biosensing systems such as nano-thermometry-based sensing platforms, mechanical sensing platforms encompassing piezoelectric-based sensors, electrochemical impedance spectroscopy based on PEGylated arginine functionalized magnetic nanoparticles, and field-effect transistor-based platforms for the early detection of cervical cancer. Also, it presents conventional platforms such as vibrational spectroscopy and polymerase chain reaction techniques for the diagnosis of cervical cancer. Finally, it reviews currently available biomarkers for the early diagnosis of cervical cancer and presents strategies for developing novel biomarkers based on cellular and molecular approaches. As such, this book is a comprehensive resource for researchers and clinicians working in cervical cancer diagnostics.
    Type of Medium: Online Resource
    Pages: IX, 115 p. 18 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811625862
    DDC: 571.978
    Language: English
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  • 100
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Cytology. ; Cancer Microenvironment. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: 1. The Tumour Microenvironment and Circulating Tumour Cells: A partnership driving metastasis and glycan-based opportunities for cancer control -- 2. Dormancy in the Tumor Microenvironment -- 3. Tumor-associated tertiary lymphoid structures: A cancer biomarker and a target for next-generation immunotherapy -- 4. Studying the tumor microenvironment in zebrafish -- 5. Pre-metastatic niche formation by neutrophils in different organs -- 6. Tumor cell invasion and the tumor microenvironment: Special focus on brain tumors -- 7. The dog as a model to study the tumor microenvironment -- 8. EFFEROCYTOSIS AND THE STORY OF “FIND ME’’, ‘’EAT ME” AND “DON’T EAT ME” SIGNALING IN THE TUMOR MICRO ENVIRONMENT -- 9. Color-coded imaging of the tumor micro-environment (TME) in human patient-derived orthotopic xenograft (PDOX) mouse models -- 10. Mitochondria and the tumor microenvironment in blood cancer -- 11. Telocytes in the tumor microenvironment -- 12. Modeling the roles of astrocytes in the metastatic tumor cell microenvironment -- 13. Roles of fibroblasts in microenvironment formation associated with radiation-induced cancer -- 14. Tumor microenvironment-associated pericyte populations may impact therapeutic response in thyroid cancer -- 15. The adrenergic nerve network in cancer -- 16. Current treatment modalities targeting tumor microenvironment in castration-resistant prostate cancer -- 17.Brain metastases and tumor microenvironment -- 18. MIGRATION STIMULATING FACTOR (MSF). ITS ROLE IN THE TUMOUR -- MICROENVIRONMENT -- 19. Mechanical Signaling in the Mammary Microenvironment - from Homeostasis to Cancer -- 20. Osteopontin Signaling in Shaping Tumor Microenvironment Conducive to Malignant Progression -- 21. Progesterone receptor signaling in the breast tumor microenvironment -- 22. Progranulin/GP88, a complex and multi-faceted player of tumor growth by direct action and via the tumor microenvironmen -- 23. Sex-based differences in the tumor microenvironmet. .
    Abstract: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 548 p. 79 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030731199
    Series Statement: Advances in Experimental Medicine and Biology, 1329
    DDC: 571.978
    Language: English
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