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  • 1
    Online Resource
    Online Resource
    Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Cancer Biology. ; Oncology.
    Description / Table of Contents: Role of specific phytochemicals against gastrointestinal malignancies -- Role of phytochemicals on growth and metastasis of GI cancer -- Cancer Stem Cells as Therapeutic Targets for Gastrointestinal cancers -- Phytochemicals plus checkpoint inhibitors in GI cancers -- Crucial role of curcumin on gut microbiota associated with GI cancers -- Cellular and Molecular mechanisms of garlic compounds in common GI cancers -- Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy -- Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer -- Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors -- Therapeutic Efects Of Curcumin Against Colorectal Cancer -- Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes -- Role of Dietary Supplementation of Natural products in the Prevention and Treatment of Liver Diseases -- Emerging Roles of Phytochemicals in Hepatocellular Carcinoma -- Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma -- Index.
    Abstract: Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
    Type of Medium: Online Resource
    Pages: XI, 340 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484057
    URL: https://doi.org/10.1007/978-3-030-48405-7
    DOI: 10.1007/978-3-030-48405-7
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Ultra-Weak Photon Emission from Biological Systems : Endogenous Biophotonics and Intrinsic Bioluminescence (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Biomedical engineering. ; Biotechnology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Introduction -- Part 1. History of UPE research -- Mitogenetic rays -- Oxidation, free-radicals and ultraweak luminescence -- Biophotons and the International Institute of Biophysics (IIB) -- Part 2. Physics of light and light research -- Physics of photon emission -- Chemiluminescence as a tool for free radical research -- Highly sensitive imaging and spectral analysis of UPE from biological systems and their application -- Part 3. Molecular mechnisms of UPE -- Free radicals in biology -- Ultraweak luminescence from aqueous systems -- Chemiluminescence in oxidation of hydrocarbons: mechanistic fundamentals -- Chemiluminescence in oxidation of fatty acids and lipids -- Chemiluminescence in protein oxidation -- Emitters of endogenous biological chemiluminescence: quantum chemical modeling insights -- Enzymatic sources of free radicals -- Part 4. UPE research in life science -- Luminescence of animal tissues and vegetable oils -- Ultraweak photon emission from human body in relation to anatomy and histology -- Chronobiological aspects of spontaneous ultra-weak photon emission in humans: Ultradian, circadian and infradian rhythms -- Autoluminescence in seedlings: applications -- Application potentiality of Delayed Luminescence in Medicine, Biology and Food Quality researches -- Part 5. Mitogenetic effect and related phenomena: unresolved problems of UPE -- Mitogenetic effect: preface -- Mitogenetic effect in biological systems -- Physical properties of mitogenetic radiation -- Secondary, degradation and necrobiotic radiation -- Mitogenetic research in medicine: radiation of blood and cancer diagnostics -- Part 6. Non-chemical distant interaction hypothesis - pro et contra -- Non-chemical distant interaction: preface -- The possible functions of electromagnetic cell communication -- Understanding of Fritz-Albert Popp’s biophoton theory from the viewpoint of a biologist -- Limits to the information transfer through UPE -- Quantum nonlocality and biological coherence -- Part 7. Perspectives -- Integrating ultraweak photon emission in mitochondrial research -- Selected biophysical methods for enhancing biological autoluminescence -- Upconverting nanoparticles as sources of singlet oxygen -- Upconverting nanoparticles as sources of singlet oxygen -- Delayed Luminescence as a tool to study the structures of systems of biological interest and their collective long-living excited states -- Index.
    Abstract: This book addresses the phenomenon of biological autoluminescence (also known as ultraweak photon emission, UPE, biochemiluminescence, or biophotons) and deals with a very broad spectrum of subjects, ranging from basic observational studies to molecular mechanisms, free-radical processes, physics of electron excitation and photon emission, as well as detection techniques. The chapter topics include UPE in plants, animals, and the human body; microorganisms and subcellular structures; and model systems, illustrating its high prevalence. Several sections of the book provide some backstory, with emphasis on methodology, unresolved questions, and existing controversies. The authors raise and discuss complex, potentially divisive aspects: Are there any reasons to assume the existence of non-chemical interaction in biological systems? Can research results in the field of mitogenetic radiation, delayed luminescence, and oxychemiluminescence of model systems, be correctly interpreted? What does the future hold for this area of research? Altogether, this publication gives the reader a thorough overview of biological autoluminescence (UPE, biophotonics) research, making it ideal for students and researchers who are new to the area as well as those who are specializing in it.
    Type of Medium: Online Resource
    Pages: XII, 521 p. 345 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031390784
    URL: https://doi.org/10.1007/978-3-031-39078-4
    DOI: 10.1007/978-3-031-39078-4
    DDC: 660.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Thermophilic Anaerobes : Phylogeny, Physiology and Biotechnological Applications (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Microbiology. ; Bacteria. ; Archaebacteria. ; Microbial ecology. ; Biotechnology. ; Microbiology. ; Bacteria. ; Archaea. ; Environmental Microbiology.
    Description / Table of Contents: Part I: General topics -- Geothermal habitats and adaptations of thermophilic microbes -- Diversity of thermophilic prokaryotes -- Molecular basis for thermostability -- Cultivation techniques and molecular methods of identification of thermophilic, anaerobic bacteria -- Part II: Biochemistry and Physiology of thermophiles -- Physiology of chemoheterotrophic thermoanaerobes -- Part III: Biotechnological Applications -- Thermostable enzymes and their applications -- Production of biofuels by thermoanaerobic bacteria -- Production of fine chemicals by thermophilic, anaerobic bacteria -- Part IV: Future aspects -- Potential of anaerobic thermophiles and future prospects.
    Abstract: Hot environments are diverse environments that habor a wide variety of anaerobic microorganisms. Although the existence of thermophilic microorganisms has been known for over a century, it is only since the 1970s that warm environments inhabited by thermophiles have been studied in more detail. While aerobic thermophiles have received most of the interest, thermophilic anaerobes have received less attention. This book provides a comprehensive overview of the fundamental aspects of thermophilic anaerobes, from their environments to their applications in biotechnology. The book is divided into three parts: 1) a general overview of thermophilic anaerobes, their history, environments, and phylogenetic relationships, 2) physiological aspects of thermophilic anaerobes and their mechanisms of thermal adaptation, and 3) the biotechnological applications of thermophiles for the production of biofuels and other chemical building blocks as well as their applications in specific industries. This comprehensive and up-to-date book, Thermophilic anaerobes - Phylogeny, Physiology and Biotechnological Applications, is a valuable resource for experienced researchers and early career scientists alike who want to learn more about this exciting and developing field.
    Type of Medium: Online Resource
    Pages: VI, 244 p. 36 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031417207
    Series Statement: Emerging Issues and Trends,
    URL: https://doi.org/10.1007/978-3-031-41720-7
    DOI: 10.1007/978-3-031-41720-7
    DDC: 660.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Regenerative Medicine and Stem Cell Biology (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Regenerative medicine. ; Reproductive health. ; Stem cells. ; Cancer. ; Biomedical engineering. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Reproductive Medicine. ; Stem Cell Biology. ; Cancer Biology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Chapter 1. Basic Concepts of Stem Cells: The Facts and Hype in Stem Cells Research and Development -- Chapter 2. Embryonic and Pluripotent Stem Cells -- Chapter 3. Adult Stem Cells: Hematopoietic Stem Cells, and Control Of Hematopoiesis -- Chapter 4. Adult Stem Cells: Adult Stem Cells: Mesenchymal Stromal Cells, Endothelial Progenitor Cells and Pericytes -- Chapter 5. Cancer Stem Cells and the Development of Cancer -- Chapter 6. Stem Cell Applications In Metabolic Disorders: Diabetes Mellitus -- Chapter 7. Epigenetics in Stem Cell Biology -- Chapter 8. Practicum: Isolation of Bone Marrow and Adipose Tissue Mesenchyme Stromal Cells -- Chapter 9. Induced Pluripotent Stem Cells: Biology, History and in-vitro Generation -- Chapter 10. Tissue Engineering Modalities and Nanotechnology -- Chapter 11. Practicum: Scaffold engineering using the amniotic membrane -- Chapter 12. The Scientific Method, Ethical Consideration and Implications in Stem Cell Research.
    Abstract: This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.
    Type of Medium: Online Resource
    Pages: X, 374 p. 45 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030553593
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-55359-3
    DOI: 10.1007/978-3-030-55359-3
    DDC: 660.6
    Language: English
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  • 5
    Online Resource
    Online Resource
    Tissue Engineering : Principles, Protocols, and Practical Exercises (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Regenerative medicine. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Reference search, image & data analysis -- Organ structure & vascularization -- Extracellular matrix & adhesion molecules -- Isolating cells from tissue -- Functional assays & toxicity screening -- Culturing cells in 2D & 3D -- Imaging, staining & markers -- Stems cells & basics of immunology -- Natural & artificial Scaffolds -- Casting & 3D bioprinting -- Bioreactors -- Reporting results -- Index. .
    Abstract: Tissue engineering and regenerative medicine is a new, interdisciplinary branch of science that combines knowledge from numerous scientific fields including biology, biochemistry, physics, chemistry, applied engineering, and medicine. It aims to restore damaged parts of the human body by rebuilding them in vitro using individual building blocks of biological tissues such as cells and the extracellular matrix that surrounds them. The authors hope to spark students’ interest in this exciting new field of science as well as give them a basic knowledge of its terminology. This book is based on a hands-on practical course in tissue engineering conducted by the Fulbright US Scholar recipient, Dr. Narine Sarvazyan (George Washington University, Washington USA). It provides an overview of the core topics of the tissue engineering field, including stem cell differentiation, the role of extracellular matrix and attachment proteins, scaffolds, and culturing of engineered tissues. Each chapter is accompanied by hands-on demonstrations and self-check questions. The text is easily readable for students of all backgrounds and the described protocols can be conducted using common lab equipment. This textbook is also useful for developing undergraduate and graduate courses that teach basic methods and approaches in this promising and rapidly developing field. .
    Type of Medium: Online Resource
    Pages: XXIV, 154 p. 80 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030396985
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-39698-5
    DOI: 10.1007/978-3-030-39698-5
    DDC: 660.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Novel Innovation Design for the Future of Health : Entrepreneurial Concepts for Patient Empowerment and Health Democratization (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Entrepreneurship. ; New business enterprises. ; Public health. ; Biotechnology. ; Biomedical Research. ; Entrepreneurship. ; Public Health.
    Description / Table of Contents: Part I. What Is Wrong with Health? What Should the Future of Health Be? -- INNOVATION DESIGN for the FUTURE of HEALTH -- Health Innovations from an Innovators’ Perspective -- From SICKCARE to HEALTHCARE to HEALTH -- Future Look on Health: Opportunities -- Navigating Towards a Future of “One Health” -- Part II. Exponential Medicine + Technologies + Mindset -- Exponential Technologies for an Exponential Medicine -- Exponential Medicine: Challenges of Human Spaceflight Bringing Innovations for Earth—A Case Study -- Healthy Longevity -- The Science of Health Longevity -- Space Healthtech: Innovation Base for Longevity -- Part III. Future Health Value Propositions -- Healthcare the Melting Pot of Technology, Humanity, and Confusion -- Democratize Health Delivery -- Health Innovation Process: Definitions and Short Methodology Introductions -- Prevention, Prediction, Personalization, and Participation as Key Components in Future Health -- Digital Health Business Models: Transformation Is on the Horizon -- Value Propositions for Future Health Developments: Digital, Portable, Connected, Experience-Enhancing, Supportive, Patient-Centric, and Affordable -- (Digital) Patient Journey and Empowerment: Digital Twin -- Part IV. Innovation Methodology Basics -- Stanford Biodesign as Base: Empathy and Patient Centricity as the Main Driver -- Purpose Launchpad Methodology: Introduction -- Design Thinking for Innovations in Healthcare -- VPC to BMC to Exponential Canvas: Canvas Interconnectivity for Exponential Scaling -- Innovation Methodology I3 EME: Awareness for Biomedical Engineers -- Part V. Ethics + Health Innovation -- Integrating Ethical Considerations into Innovation Design -- Part VI. Health Innovation Design -- Case Studies Used Throughout the Book: Innovation Categories Explained -- Why Is Healthcare Different with Respect to Innovation and Entrepreneurial Activities? -- Purpose Launchpad Health (PLH) Methodology Introduction -- Part VII. Purpose Launchpad Health -- Purpose Launchpad Health: Exploration and Evaluation Phases—Actual Case Studies -- Part VIII. Health Leadership, Skills and other Methodologies -- Soft Skills Needed for Problem Understanding and Innovation Generation -- Leadership in Healthcare: A Novel Approach. Healthcare Executives’ Traits, Styles, and Approaches -- Future Skills Framework in Healthcare -- Porter’s Five Forces Analysis: Quo Vadis Immunotherapy Industry -- Part IX. Health Entrepreneurship -- Global Health Markets and Their Different Needs -- Patient: Health Relation and Digital Health Entrepreneurship -- Health Start-Up: Create Impact and be Investment Ready Intra- and Entre-Preneurs -- Regulatory Issues for Health Innovations -- Innovation Think Tank Frameworks for Resolving “The Innovator’s Dilemma” in Healthcare -- A Primer on Patents and IP for Health Innovations -- Successfully Implementing Ambidexterity in the Medical Industry -- Reverse Innovation: Circumvent Digital Health Transformation Issues -- Part X. Health Innovation Education and Incubation -- Health Innovation Design: “CAMPing” for the Unmet Clinical Need -- Health Technology Innovation Generation (HTIG) Lecture and Project Classes at AGH University -- Health Innovation Design at a University: INKA INNOLAB at Otto-von-Guericke-University -- Clinical Innovation at Acibadem Biodesign Center -- Example of a Needs-Driven Innovation Training Program: The BioMedical Design Novo Nordisk Foundation Fellowship Program -- Addressing the Healthcare Needs with Innovation Think Tank Global Infrastructure and its Methodology -- The Power of a Collaborative Ecosystem: Introducing the Edison™ Accelerator -- HealthTec Networks and Clusters (Global): Innovation Clusters in Medtech in Europe -- Leadership-Compass: “Networking and Synapting Empowered by Health Captains” -- Part XI. Purpose Launchpad Health: Toolset Templates and Principles -- PLH Templates and Principles.
    Abstract: This book highlights the reasons for an urgently needed revision of the current global healthcare setup, discusses the needed mindset for a future of health, and provides a comprehensive development toolset for disruption (and for the needed incremental innovations towards disruption). Today’s biomedical and health innovation related research in universities encourages activities that lead to incremental innovations with a relatively low risk of failure. The healthcare industry on the other hand provides tools and devices for established healthcare providers to improve the diagnosis and therapy/ treatment of the patients’ health problems. The patient is not in the center of healthcare provision however, and prevention and prediction are not core goals. The current health setup needs to be challenged and disrupted. Disruptions are coming from technologies or processes that lead to a significant (〉10x) reduction in cost or price/ performance and that also come with new business models. The need for change, effects of exponential technologies, and the needed shift to prevention and to homecare for health democratization and patient empowerment will be discussed in detail in the first parts of the book. The subsequent sections address several innovation methods with a focus on a novel meta methodology named Purpose Launchpad Health. This is followed by a comprehensive discussion on health entrepreneurship activities and needs. The final section of the book addresses how to train students to become entrepreneurial health innovators, presenting successful curricula and examples of health incubation and accelerator setups. All of the innovation tools presented and used in this book are summarized in the final chapter to help the reader get started planning an entrepreneurial venture. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments. Chapters are concise and enriched with key messages, learning objectives and real innovation examples to bridge theory and practice. This book aims to serve as a teaching base for health innovation design and to prepare for health-related entrepreneurial ventures. Readers with medical, biomedical, biotechnology, and health economics backgrounds - and anyone who wants to become a future oriented health innovator or who believes in disruptive approaches - will find this book a useful resource and teaching tool for developing validated products/ services and processes for the future of health.
    Type of Medium: Online Resource
    Pages: XXXIV, 624 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031081910
    URL: https://doi.org/10.1007/978-3-031-08191-0
    DOI: 10.1007/978-3-031-08191-0
    DDC: 660.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Heparanase : From Basic Research to Clinical Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    URL: https://doi.org/10.1007/978-3-030-34521-1
    DOI: 10.1007/978-3-030-34521-1
    DDC: 571.978
    Language: English
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  • 8
    Online Resource
    Online Resource
    Circulating Tumor Cells : Advances in Liquid Biopsy Technologies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    URL: https://doi.org/10.1007/978-3-031-22903-9
    DOI: 10.1007/978-3-031-22903-9
    DDC: 571.978
    Language: English
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  • 9
    Online Resource
    Online Resource
    Biobanks in Low- and Middle-Income Countries: Relevance, Setup and Management (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Biomaterials. ; Biology Technique. ; Biotechnology. ; Biomaterials. ; Biological Techniques.
    Description / Table of Contents: Introduction to Biobanking -- Scientific Relevance, Problems and the Destitution for Principles of Biobanks and Biobanking Activities -- Types of Biobanks -- Ethical and Legal Principles in the Field of Biobanking -- Business Planning for Biobanks -- Biobanking Concepts Specific for Developing Countries -- Methods of Implementation and Set-up of National Biobanking Networks -- Implementation of Ethical and Legal Considerations in a Biobanking Network -- Collection and Management of Samples -- Quality Control and Risk Management in Biobanks -- Governance and Stakeholder Analysis -- Biobanking IT Systems, Database Structure and Web Applications -- Management Model and Sustainability Plan of Biobanks -- Sustainability Plan and Project Management of a Biobanking Network -- Establishing a Biobank Using Standardisation -- Science and Innovation of Biobanks -- Running a Biobank Network -- Infrastructure: Delivering on the Promise of Biobanking -- Design Considerations and Equipment of Biobanks -- Software Tools for Biobanking in LMICs -- The Importance of Cancer Biobanks in Low- and Middle-Income Countries -- Biobanking in Paediatrics: A Look from Armenia as a Middle-Income Country -- Biobanking of the Central Nervous System -- The Importance of Biobanking COVID-19 Samples -- Oncobiobanking in a Middle-Income Country: The Example of Russia -- Sustainability of Biobanks and Biobanking in LMICs -- Biobanks for Enabling Research and Development by Trusted Patient Data Environment -- Future Perspective of the Biobanking Field.
    Abstract: This book introduces the fundamentals of biobanking and guides through the practical planning thereof, with a special focus on the situation in low- and middle-income countries. On the example of the setup of a Ukrainian biobank the book discusses the main steps and aspects of successful biorepository implementation and management. Topics covered include collection, storage and shipping of samples, establishment of an IT system, development of a sustainability plan, and project and risk management. Furthermore, the importance of the formation of international biobanking societies such as the Ukraine Association of Biobanks is highlighted, and their main objectives and tasks are discussed. The book addresses life science and business professionals as well as national authorities who are interested in biobanking in general and in setting up a biobank in particular.
    Type of Medium: Online Resource
    Pages: XVII, 235 p. 25 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030876371
    URL: https://doi.org/10.1007/978-3-030-87637-1
    DOI: 10.1007/978-3-030-87637-1
    DDC: 660.6
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cancer Neuroscience (2023)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.
    Abstract: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
    Type of Medium: Online Resource
    Pages: XII, 202 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324291
    URL: https://doi.org/10.1007/978-3-031-32429-1
    DOI: 10.1007/978-3-031-32429-1
    DDC: 571.978
    Language: English
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