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  • Books  (50)
  • Biology Research.  (23)
  • Biomedical Research.  (23)
  • Nanotechnology.  (16)
  • Bioinformatics.
  • 660.6  (31)
  • 571.978  (19)
  • 624.151
  • 1
    Online Resource
    Online Resource
    Lipid Metabolism in Tumor Immunity (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.
    Abstract: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .
    Type of Medium: Online Resource
    Pages: XI, 211 p. 24 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813367852
    Series Statement: Advances in Experimental Medicine and Biology, 1316
    URL: https://doi.org/10.1007/978-981-33-6785-2
    DOI: 10.1007/978-981-33-6785-2
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    NanoBioMedicine (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Nanotechnology. ; Cancer. ; Stem cells. ; Diseases. ; Biotechnology. ; Nanotechnology. ; Cancer Biology. ; Stem Cell Biology. ; Diseases.
    Description / Table of Contents: Chapter 1.Current Advances in Nanotechnology and Medicine -- Chapter 2. Least Explored Small Wonders: Nano-biotechnology -- Chapter 3. Modern Approaches in Nanomedicine for neuroAIDS and CNS drug delivery -- Chapter 4. Nanobiotechnology: Paving the way to personalized medicine -- Chapter 5. Nanomedicine in cancer stem cell therapy -- Chapter 6. Nanobiosensor: Current Trends and Applications -- Chapter 7. Transition Metal Oxide Nanoparticles: A New Horizon in Cancer Treatment -- Chapter 8. Nanomedicine meets microRNA expression and function in prostate cancer -- Chapter 9. Biomedical applications of Viral Nanoparticles in vaccine therapy -- Chapter 10. HIV: Biology to Nanomedicine -- Chapter 11. Current Advances in Phage Inspired Nanocarriers Based Therapy -- Chapter 12. Nanophytotherapeutic potential of Essential Oils against Candida infections -- Chapter 13. Molecular tests for the Diagnosis of Tuberculosis: Nanodiagnostics Approaches -- Chapter 14. Molecular Mechanisms of drug resistance in Mycobacterium tuberculosis: Role of nanoparticles against Multi-Drug Resistant tuberculosis (MDR-TB) -- Chapter 15. Nano-Mass spectrometry (nano-MS) based lipidomics -- Chapter 16. Techniques to understand Mycobacterial Lipids and use of Lipid Based Nanoformulations for Tuberculosis Management -- Chapter 17. Recent trends and challenges in Patches for cardiac tissue reengineering: role of Nanomaterials -- Chapter 18. Cyclic dinucleotides: Big roles of small molecules and its role in nanotechnology and medicine -- Chapter 19. Antibodies: Biology to Therapeutics and its role in nanomedicine -- Chapter 20. Nanotoxicology in Medicine -- Chapter 21. Antibody-targeted nanoparticles for cancer treatment -- Chapter 22. Nanoparticle mediated combined photothermal and photodynamic therapy -- Chapter 23. Nanotechnology based devices and its applications in medicine- Chapter 24. Opportunities in clinical translation and commercialization of nanomedicine. .
    Abstract: This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology. .
    Type of Medium: Online Resource
    Pages: XX, 517 p. 90 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813298989
    URL: https://doi.org/10.1007/978-981-32-9898-9
    DOI: 10.1007/978-981-32-9898-9
    DDC: 660.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Immobilization Strategies : Biomedical, Bioengineering and Environmental Applications (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Microtechnology. ; Microelectromechanical systems. ; Enzymology. ; Nanotechnology. ; Biotechnology. ; Microsystems and MEMS. ; Enzymology. ; Nanotechnology.
    Description / Table of Contents: Immobilization: Then and Now -- Cell immobilization strategies for tissue engineering: Recent trends and future perspectives -- Strategies and advancement in growth factor immobilizable ECM for tissue engineering -- Prospects Of Cell Immobilization In Cancer Research And Immunotherapy -- Nano systems for repairing retinal degeneration -- Systemic drug delivery to the posterior segment of the eye: Overcoming blood-retinal barrier through smart drug design and nanotechnology -- The effects of irradiation with cold atmospheric-pressure plasma on cellular function -- Immobilization of biomolecules on plasma functionalized surfaces for biomedical applications -- A wide portray of Upconversion-nanoparticles: surface modification for bio-applications -- Advances in Amphiphilic Assemblies and its Immobilization in Room Temperature Supercooled Matrices. .
    Abstract: This book delves into the field of immobilizing biologically active and non-active molecules. It discusses the designing strategy of immobilization and the current state-of-the-art applications for advancing biomedical, agricultural, environmental and industrial practices. It focuses on aspects ranging from fundamental principles to current technological advances at multi-scale levels (macro, micro, and nano) which are suitable for cell, enzyme, and nano-catalyst based applications. Written by experts from across the globe, the contents deal with illustrated examples of molecular and cellular interactions with materials/scaffolds and discussions on factors that can affect the functionality and yield of the process. With its discussions on material science, design of delivery vehicles, separation science, additive manufacturing, agriculture and environmental science, this book will be a useful reference for researchers across multiple disciplines.
    Type of Medium: Online Resource
    Pages: X, 666 p. 143 illus., 126 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811579981
    Series Statement: Gels Horizons: From Science to Smart Materials,
    URL: https://doi.org/10.1007/978-981-15-7998-1
    DOI: 10.1007/978-981-15-7998-1
    DDC: 660.6
    Language: English
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  • 4
    Online Resource
    Online Resource
    Obesity and Cancer (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Diseases. ; Immunology. ; Bioinformatics. ; Cancer Biology. ; Diseases. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Obesity induced chronic low-level inflammation and cancers -- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers -- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation -- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer -- Chapter 6. Immune response and oxidative stress in obesity induced cancer -- Chapter 7. Role of gene polymorphism in obesity and cancer -- Chapter 8. Therapeutic role of green tea in obesity and cancer -- Chapter 9. Effect of dietary phytochemicals in obesity and cancer -- Chapter 10. Resveratrol as anti-obesity and anticancer agent -- Chapter 11. EGCG as anti-obesity and anticancer agent -- Chapter 12. miRNAs as therapeutic target in obesity and cancer -- Chapter 13. In silico updates on lead identification for obesity and cancer -- Chapter 14. In vivo models for obesity and obesity related carcinogenesis -- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases -- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.
    Abstract: This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. .
    Type of Medium: Online Resource
    Pages: IX, 361 p. 38 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618468
    URL: https://doi.org/10.1007/978-981-16-1846-8
    DOI: 10.1007/978-981-16-1846-8
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Deep Learning in Medical Image Analysis : Challenges and Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Biomedical engineering. ; Radiology. ; Bioinformatics. ; Biotechnology. ; Biomedical Engineering and Bioengineering. ; Radiology. ; Computational and Systems Biology.
    Description / Table of Contents: Deep Learning in Medical Image Analysis -- Medical Image Synthesis via Deep Learning -- Deep Learning for Pulmonary Image Analysis: Classification, Detection, and Segmentation -- Deep Learning Computer Aided Diagnosis for Breast Lesion in Digital Mammogram -- Decision support system for lung cancer using PET/CT and microscopic images -- Lesion Image Synthesis using DCGANs for Metastatic Liver Cancer Detection -- Retinopathy analysis based on deep convolution neural network -- Diagnosis of Glaucoma on retinal fundus images using deep learning: detection of nerve fiber layer defect and optic disc analysis -- Automatic segmentation of multiple organs on 3D CT images by using deep learning approaches -- Techniques and Applications in Skin OCT Analysis -- Deep Learning Technique for Musculoskeletal Analysis -- Index.
    Abstract: This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.
    Type of Medium: Online Resource
    Pages: VIII, 181 p. 131 illus., 114 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030331283
    Series Statement: Advances in Experimental Medicine and Biology, 1213
    URL: https://doi.org/10.1007/978-3-030-33128-3
    DOI: 10.1007/978-3-030-33128-3
    DDC: 660.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Novel Innovation Design for the Future of Health : Entrepreneurial Concepts for Patient Empowerment and Health Democratization (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Entrepreneurship. ; New business enterprises. ; Public health. ; Biotechnology. ; Biomedical Research. ; Entrepreneurship. ; Public Health.
    Description / Table of Contents: Part I. What Is Wrong with Health? What Should the Future of Health Be? -- INNOVATION DESIGN for the FUTURE of HEALTH -- Health Innovations from an Innovators’ Perspective -- From SICKCARE to HEALTHCARE to HEALTH -- Future Look on Health: Opportunities -- Navigating Towards a Future of “One Health” -- Part II. Exponential Medicine + Technologies + Mindset -- Exponential Technologies for an Exponential Medicine -- Exponential Medicine: Challenges of Human Spaceflight Bringing Innovations for Earth—A Case Study -- Healthy Longevity -- The Science of Health Longevity -- Space Healthtech: Innovation Base for Longevity -- Part III. Future Health Value Propositions -- Healthcare the Melting Pot of Technology, Humanity, and Confusion -- Democratize Health Delivery -- Health Innovation Process: Definitions and Short Methodology Introductions -- Prevention, Prediction, Personalization, and Participation as Key Components in Future Health -- Digital Health Business Models: Transformation Is on the Horizon -- Value Propositions for Future Health Developments: Digital, Portable, Connected, Experience-Enhancing, Supportive, Patient-Centric, and Affordable -- (Digital) Patient Journey and Empowerment: Digital Twin -- Part IV. Innovation Methodology Basics -- Stanford Biodesign as Base: Empathy and Patient Centricity as the Main Driver -- Purpose Launchpad Methodology: Introduction -- Design Thinking for Innovations in Healthcare -- VPC to BMC to Exponential Canvas: Canvas Interconnectivity for Exponential Scaling -- Innovation Methodology I3 EME: Awareness for Biomedical Engineers -- Part V. Ethics + Health Innovation -- Integrating Ethical Considerations into Innovation Design -- Part VI. Health Innovation Design -- Case Studies Used Throughout the Book: Innovation Categories Explained -- Why Is Healthcare Different with Respect to Innovation and Entrepreneurial Activities? -- Purpose Launchpad Health (PLH) Methodology Introduction -- Part VII. Purpose Launchpad Health -- Purpose Launchpad Health: Exploration and Evaluation Phases—Actual Case Studies -- Part VIII. Health Leadership, Skills and other Methodologies -- Soft Skills Needed for Problem Understanding and Innovation Generation -- Leadership in Healthcare: A Novel Approach. Healthcare Executives’ Traits, Styles, and Approaches -- Future Skills Framework in Healthcare -- Porter’s Five Forces Analysis: Quo Vadis Immunotherapy Industry -- Part IX. Health Entrepreneurship -- Global Health Markets and Their Different Needs -- Patient: Health Relation and Digital Health Entrepreneurship -- Health Start-Up: Create Impact and be Investment Ready Intra- and Entre-Preneurs -- Regulatory Issues for Health Innovations -- Innovation Think Tank Frameworks for Resolving “The Innovator’s Dilemma” in Healthcare -- A Primer on Patents and IP for Health Innovations -- Successfully Implementing Ambidexterity in the Medical Industry -- Reverse Innovation: Circumvent Digital Health Transformation Issues -- Part X. Health Innovation Education and Incubation -- Health Innovation Design: “CAMPing” for the Unmet Clinical Need -- Health Technology Innovation Generation (HTIG) Lecture and Project Classes at AGH University -- Health Innovation Design at a University: INKA INNOLAB at Otto-von-Guericke-University -- Clinical Innovation at Acibadem Biodesign Center -- Example of a Needs-Driven Innovation Training Program: The BioMedical Design Novo Nordisk Foundation Fellowship Program -- Addressing the Healthcare Needs with Innovation Think Tank Global Infrastructure and its Methodology -- The Power of a Collaborative Ecosystem: Introducing the Edison™ Accelerator -- HealthTec Networks and Clusters (Global): Innovation Clusters in Medtech in Europe -- Leadership-Compass: “Networking and Synapting Empowered by Health Captains” -- Part XI. Purpose Launchpad Health: Toolset Templates and Principles -- PLH Templates and Principles.
    Abstract: This book highlights the reasons for an urgently needed revision of the current global healthcare setup, discusses the needed mindset for a future of health, and provides a comprehensive development toolset for disruption (and for the needed incremental innovations towards disruption). Today’s biomedical and health innovation related research in universities encourages activities that lead to incremental innovations with a relatively low risk of failure. The healthcare industry on the other hand provides tools and devices for established healthcare providers to improve the diagnosis and therapy/ treatment of the patients’ health problems. The patient is not in the center of healthcare provision however, and prevention and prediction are not core goals. The current health setup needs to be challenged and disrupted. Disruptions are coming from technologies or processes that lead to a significant (〉10x) reduction in cost or price/ performance and that also come with new business models. The need for change, effects of exponential technologies, and the needed shift to prevention and to homecare for health democratization and patient empowerment will be discussed in detail in the first parts of the book. The subsequent sections address several innovation methods with a focus on a novel meta methodology named Purpose Launchpad Health. This is followed by a comprehensive discussion on health entrepreneurship activities and needs. The final section of the book addresses how to train students to become entrepreneurial health innovators, presenting successful curricula and examples of health incubation and accelerator setups. All of the innovation tools presented and used in this book are summarized in the final chapter to help the reader get started planning an entrepreneurial venture. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments. Chapters are concise and enriched with key messages, learning objectives and real innovation examples to bridge theory and practice. This book aims to serve as a teaching base for health innovation design and to prepare for health-related entrepreneurial ventures. Readers with medical, biomedical, biotechnology, and health economics backgrounds - and anyone who wants to become a future oriented health innovator or who believes in disruptive approaches - will find this book a useful resource and teaching tool for developing validated products/ services and processes for the future of health.
    Type of Medium: Online Resource
    Pages: XXXIV, 624 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031081910
    URL: https://doi.org/10.1007/978-3-031-08191-0
    DOI: 10.1007/978-3-031-08191-0
    DDC: 660.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Composite Materials: Applications in Engineering, Biomedicine and Food Science (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Food science. ; Biomaterials. ; Nanotechnology. ; Ceramic materials. ; Biotechnology. ; Food Science. ; Biomaterials. ; Nanotechnology. ; Ceramics.
    Description / Table of Contents: Carbon materials from various sources for composite materials -- Carbon Fibre Reinforced Polymer (CFRP) Composites: Machining Aspects and Opportunities for Manufacturing Industries -- Surface modification of graphene nanoplatelets (GNP) towards preparation of natural/synthetic rubber blend nanocomposites -- Mechanical properties of nanoclay composite materials -- Fireproof capability of rigid polyurethane foam based composite materials -- Structural behavior of composite materials in fire -- Natural resources based green composite materials -- Composite materials for wind turbine structure -- Electrochromic Smart Windows: An Energy-efficient Technology -- Graphitic Carbon Nitride/ Metal Oxides Nanocomposites and Their Applications in Engineering -- Application of Nanofiber-based Composites: Progressive Health Impact -- Polymer-based Nanocomposite: Recent Trends in Safety Assessments in biomedical applications -- Modern approach of hydroxyapatite based composites for biomedical applications -- Hybrid Composite in Orthopedic applications -- Polymer-based composite in biomedical applications -- Components of All-solid-state Ion-Selective Electrodes (AS-ISEs) -- Nanocellulose and Nanocellulose-based Composites for Food Applications -- Nanocomposite Materials in Food Packaging: Opportunities, Challenges and Safety Assessment -- Biodegradability and Composite Coatings: Past, Present and Future Prospects -- Nanocomposite Film for Food Packaging: Opening Doors to Future Applications -- Functional Chitosan-Based Composites for Potential Application in Food Industry -- Metal-insulator-metal as a biosensing platfrom .
    Abstract: Composite materials are formed when the combination of separate materials acquire new properties distinct from its components. They have a range of applications in fields such as mechanical and electrical engineering, food science and biomedicine and represent a fast-growing area of research. Composite Materials: Applications in Engineering, Biomedicine and Food Science provides an overview of current technologies and applications related to composite materials in these fields. Organized by discipline, the text encompasses a wide variety of composite materials, including polymer, ceramic, biomaterial, hydroxyapatite, nanofiber and green composites. Early chapters detail the enhanced mechanical, magnetic, dielectric properties of electrical and thermal conductive composite materials, which are essential in daily science. Subsequent chapters focus on filler or reinforcement materials, including carbon materials, hybrid materials and nanomaterials. Particular emphasis is placed on nanocomposite materials, as these have increasingly diverse field applications. Various manufacturing methods, such as the synthesis method and top-down/bottom-up manufacturing, are also discussed. Coverage of the recent progress, challenges and opportunities surrounding composite materials make this text a one-stop reference for engineers, scientists and researchers working in this exciting field.
    Type of Medium: Online Resource
    Pages: XI, 484 p. 213 illus., 112 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030454890
    URL: https://doi.org/10.1007/978-3-030-45489-0
    DOI: 10.1007/978-3-030-45489-0
    DDC: 660.6
    Language: English
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  • 8
    Online Resource
    Online Resource
    Heparanase : From Basic Research to Clinical Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    URL: https://doi.org/10.1007/978-3-030-34521-1
    DOI: 10.1007/978-3-030-34521-1
    DDC: 571.978
    Language: English
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  • 9
    Online Resource
    Online Resource
    New Nanomaterials and Techniques for Tumor-targeted Systems (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Nanotechnology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Nanotechnology. ; Biomedical Research.
    Description / Table of Contents: 1 Introduction -- 2 Barriers for tumor drug delivery -- 3 Tumor-targeted strategies -- 4 Tumor-responsive drug release strategies -- 5 Tumor diagnosis patterns -- 6 Tumor therapeutic modes -- 7 Carbon-based tumor-targeted systems -- 8 Silica-based tumor-targeted systems -- 9 Lipid-based tumor-targeted systems -- 10 Dendrimer-based tumor-targeted systems -- 11 Polymer-based tumor-targeted systems -- 12 Other new tumor-targeted systems -- 13 Clinical applications of tumor-targeted systems -- 14 Challenges and perspectives of tumor-targeted systems.
    Abstract: This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.
    Type of Medium: Online Resource
    Pages: VI, 463 p. 72 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551598
    URL: https://doi.org/10.1007/978-981-15-5159-8
    DOI: 10.1007/978-981-15-5159-8
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    Microbial Enzymes and Biotechniques : Interdisciplinary Perspectives (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Microbiology. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Industrial microbiology. ; Biotechnology. ; Microbiology. ; Medical Microbiology. ; Biomedical Research. ; Industrial Microbiology.
    Description / Table of Contents: Chapter 1. The sugar-nucleotide providing enzyme, opportunity and future in the antibody and peptide medicine area -- Chapter 2. The Next Generation of Microalgae-Based Products -- Chapter 3. Advanced techniques for enzymatic and chemical bleaching for pulp and paper industries -- Chapter 4. Commercial bioinoculant development: Techniques and challenges -- Chapter 5. Protein nanostructures with purpose-designed properties in biotechnology and medicine -- Chapter 6. Recent advances in biosynthetic production of Biopigments from microlagae -- Chapter 7. Revealing of the features of the oxidative enzyme production by white-rot basidiomycetes during fermentation of plant raw materials -- Chapter 8. Endophytic bacterial applications in phytoremediation of organic pollutants and toxic metals -- Chapter 9. Biotechnological interventions for Arbuscular Mycorrhizal Fungi (AMF) based biofertilizer: technological perspectives -- Chapter 10. Probiotics and prebiotics: Techniques used and its relevance -- Chapter 11. Techniques of Evaluation of the chemical and microbiological quality of the coastal environment -- Chapter 12. Enzyme engineering techniques for biotechnological applications.
    Abstract: This book compiles the latest research on the multifarious roles of microbial enzymes, and provides an overview of microbial enzymes and biotechnologies. It discusses the use of microbial enzymes in innovative areas like nanomedicine and synthetic biotechnology, as well as the use of starch digesting enzymes and bioactive proteins as biotherapeutics, all of which have applications in modern drug discovery processes. The book also examines the concept of microbial biotransformation and protein engineering, and covers topics such as the immobilization of therapeutic enzymes, bioengineering of enzymes for bioactive compounds, the production of hydrolytic and oxidative enzymes from plant raw materials, and prebiotics and probiotics. Given its multidisciplinary scope, this book will appeal to researchers and industry experts in the fields of microbiology, biotechnology and molecular medicine.
    Type of Medium: Online Resource
    Pages: XIV, 249 p. 83 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811568954
    URL: https://doi.org/10.1007/978-981-15-6895-4
    DOI: 10.1007/978-981-15-6895-4
    DDC: 660.6
    Language: English
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  • 11
    Online Resource
    Online Resource
    Nanobiosensors for Agricultural, Medical and Environmental Applications (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Microtechnology. ; Microelectromechanical systems. ; Nanotechnology. ; Biotechnology. ; Microsystems and MEMS. ; Nanotechnology.
    Description / Table of Contents: Chapter 1. Opportunities for real time monitoring of biomolecules using FRET-based nanosensors -- Chapter 2. Current status of nanosensors in biological sciences -- Chapter 3. Biosensor: An Approach Towards a Sustainable Environment -- Chapter 4. Nanobiosensor in health sector: The milestones achieved and future prospects -- Chapter 5. Nanosensors based on DNA as an emerging technology for the detection of disease -- Chapter 6. Genetically Encoded Nanobiosensors for Nutrients and their applications -- Chapter 7. Development of highly sensitive optical sensors based on Carbon Nanotube (CNTs) -- Chapter 8. Recent advances of Fluorescent Resonance Energy Transfer-based nanosensors for the detection of human ailments -- Chapter 9. Application Of Nanosensors in Agriculture and Food Processing -- Chapter 10. Fluorescent Protein pairs and their application in FRET-based Nanobiosensors -- Chapter 11. Probes for Detection of Free Radicles -- .
    Abstract: This informative book compiles the most up-to-date applications of nanobiosensors in fields ranging from agriculture to medicine. The introductory section describes different types of nanobiosensors and use of nanobiosensors towards a sustainable environment. The applications are divided into four broad sections for easy reading and understanding. The book discusses how manipulation, control and integration of atoms and molecules are used to form materials, structures, devices and systems in nano-scale. Chapters in the book shed light on the use of nanosensors in diagnostics and medical devices. Application in food processing as well as in cell signaling is also described. Nanobiosensors have immense use, and this book captures the most important ones.
    Type of Medium: Online Resource
    Pages: XI, 223 p. 65 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811583469
    URL: https://doi.org/10.1007/978-981-15-8346-9
    DOI: 10.1007/978-981-15-8346-9
    DDC: 660.6
    Language: English
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  • 12
    Online Resource
    Online Resource
    Recent Advances in Biological Network Analysis : Comparative Network Analysis and Network Module Detection (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Bioinformatics. ; Medical genetics. ; Biotechnology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1: Global Alignment of PPI Networks -- Chapter 2: Integrated Network-Based Computational Analysis for Drug Development -- Chapter 3: Effective Random Walk Models for Comparative Network Analysis -- Chapter 4: Computational Methods for Protein-Protein Interaction Network Alignment -- Chapter 5: Network Propagation for the Analysis of Multi_Omics Data -- Chapter 6: Motifs in Biological Networks -- Chapter 7: Bio Fabric Visualization of Network Alignments -- Chapter 8: Module Identification of Biological Networks via Graph Partition -- Chapter 9: Network Module Detection to Decipher the Heterogeneity of Cancer Mutations.
    Abstract: This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights. .
    Type of Medium: Online Resource
    Pages: XII, 217 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571733
    URL: https://doi.org/10.1007/978-3-030-57173-3
    DOI: 10.1007/978-3-030-57173-3
    DDC: 660.6
    Language: English
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  • 13
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    Online Resource
    DNA Beyond Genes : From Data Storage and Computing to Nanobots, Nanomedicine, and Nanoelectronics (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Nanotechnology. ; Microtechnology. ; Microelectromechanical systems. ; Genetics. ; Biotechnology. ; Nanotechnology. ; Microsystems and MEMS. ; Genetics and Genomics. ; Chemical Bioengineering.
    Description / Table of Contents: Introduction: DNA basics (a primer on DNA) -- Hiding and storing messages and data in DNA -- DNA as a nanoscale building material -- DNA machines and nanobots -- DNA-based nanoelectronics -- Concluding remarks.
    Abstract: This is the first book portraying to a wide readership many fields of DNA in the world of materials altogether in a single volume. The book provides underlying concepts and state-of-art developments in the emerging fields of DNA electronics, structural DNA nanotechnology, DNA computing and DNA data storage, DNA machines and nanorobots. Future possibilities of innovative DNA-based technologies, such as DNA cryptography, DNA identity tags, DNA nanostructures in biosensing and nanomedicine, as well as DNA-based nanoelectronics are all covered, too. This book is valuable for university students studying engineering and technology; biotech, nanotech, and medical device R&D managers, practitioners and investors; and IP analysts who would like to extend their background in advanced DNA technologies. It is nicely illustrated, which makes it very readable, and it conveys science and principles in a lively language to appeal to a broad audience, from professionals and academics to students and lay readers. Advance Praise for DNA Beyond Genes: “Most students of DNA, and lay readers as well, are interested in the absolutely essential role it plays in biology. However, the properties which make DNA the carrier of genetic information also make it an extraordinary material that can be used as the backbone for a wide variety of nanoengineering applications – these range from information storage and computation to molecular machines and devices to artfully designed logos and symbols. The perfect self-recognition of DNA sequences makes it an ideal building block to synthesize more and more elaborate constructions and imaginative scientists have probably only just scratched the surface of what can eventually be created. Here for the first time in this wonderful book Vadim Demidov explores the full range of the non-biological applications of DNA.” Charles R. Cantor Professor Emeritus of Biomedical Engineering, Boston University Member of the USA National Academy of Sciences.
    Type of Medium: Online Resource
    Pages: XX, 107 p. 66 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030364342
    URL: https://doi.org/10.1007/978-3-030-36434-2
    DOI: 10.1007/978-3-030-36434-2
    DDC: 660.6
    Language: English
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  • 14
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    Online Resource
    Nanobiomaterial Engineering : Concepts and Their Applications in Biomedicine and Diagnostics (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Nanotechnology. ; Regenerative medicine. ; Immunology. ; Biotechnology. ; Nanotechnology. ; Regenerative Medicine and Tissue Engineering. ; Immunology.
    Description / Table of Contents: Chapter 1. Nanomaterials, classifications, and properties -- Chapter 2. Engineering nanomaterials for bio-interfacing -- Chapter 3. Biomaterials and surface modification strategies -- Chapter 4. Nano materials as a nanotheronostic agent -- Chapter 5. Nanobiomaterials in biomedicine: Designing strategies and critical concepts -- Chapter 6. Phytofabricated nanodelivery systems: Engineering principles and applications -- Chapter 7. Nanobiosensors based diagnostics system: Transducers and surface materials -- Chapter 8. Nanobiomaterials and nanocomposites in clinical diagnostics -- Chapter 9. Tissue Engineering and Regenerative Medicines based on nanobiomaterials -- Chapter 10. Prospects and advantages of microfluidics utilizing various nanobiomaterials -- Chapter 11. Electrochemical nanoengineered sensors in infectious disease diagnosis -- Chapter 12. Multiplexing utilizing various nanobiomaterials -- Chapter 13. Future perspects of nanobiomaterials in human health care -- Chapter 14. Commercial aspects of nanobiomaterials: Short-coming and future aspects.
    Abstract: This book comprehensively documents the application of Nanobiomaterials in the field of bio-medicine and diagnostics technologies by involving classical concepts/examples. Nanobiotechnology is an emerging area which encompasses all the facets of research of nano and biomaterials with their interaction with biological systems. The book summarises design and development of various nanobiomaterials and their composites for diagnostics and therapeutic applications. It skilfully reviews the utilization of the nanomaterials alone or in combination with other bio-molecules as a contrast enhancer in in-vivo imaging, Nano-Theranostics, drug delivery, and sensing transducer matrix. It also discusses the current research on designing of the new Nanobiomaterials and their implementation in numerous fields including bio-medicine and diagnostics. Finally, it summarizes the future prospects and the commercial viability of Nanobiomaterials in the human health care.
    Type of Medium: Online Resource
    Pages: XII, 294 p. 108 illus., 91 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813298408
    URL: https://doi.org/10.1007/978-981-32-9840-8
    DOI: 10.1007/978-981-32-9840-8
    DDC: 660.6
    Language: English
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  • 15
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    Online Resource
    Autophagy: Biology and Diseases : Technology and Methodology (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Biology Technique. ; Biotechnology. ; Biomedical Research. ; Experimental Organisms.
    Description / Table of Contents: Morphology Study – Optical Microscopy Imaging, Electron Microscopy Imaging, Confocal Microscopy Imaging, Live Cell Imaging -- Methods to Detect Autophagic Flux -- Biomarkers in Autophagy -- Drugs and Molecular Biology Technology in Autophagy Study -- Animal Models in Autophagy Study.
    Abstract: This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.
    Type of Medium: Online Resource
    Pages: XIV, 453 p. 85 illus., 79 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811628306
    Series Statement: Advances in Experimental Medicine and Biology, 1208
    URL: https://doi.org/10.1007/978-981-16-2830-6
    DOI: 10.1007/978-981-16-2830-6
    DDC: 660.6
    Language: English
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  • 16
    Online Resource
    Online Resource
    Bioimage Data Analysis Workflows (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Cytology. ; Bioinformatics. ; Biology Technique. ; Biotechnology. ; Cell Biology. ; Computational and Systems Biology. ; Biological Techniques.
    Description / Table of Contents: Workflows and Components of Bioimage Analysis -- Measurements of Intensity Dynamics at the Periphery of the Nucleus -- 3D Quantitative Colocalisation Analysis -- The NEMO Dots Assembly: Single-Particle Tracking and Analysis -- Introduction to MATLAB: Image Analysis & Brownian Motion -- Resolving the process of Clathrin Mediated Endocytosis Using Correlative Light & Electron Microscopy (CLEM).
    Abstract: This Open Access textbook provides students and researchers in the life sciences with essential practical information on how to quantitatively analyze data images. It refrains from focusing on theory, and instead uses practical examples and step-by step protocols to familiarize readers with the most commonly used image processing and analysis platforms such as ImageJ, MatLab and Python. Besides gaining knowhow on algorithm usage, readers will learn how to create an analysis pipeline by scripting language; these skills are important in order to document reproducible image analysis workflows. The textbook is chiefly intended for advanced undergraduates in the life sciences and biomedicine without a theoretical background in data analysis, as well as for postdocs, staff scientists and faculty members who need to perform regular quantitative analyses of microscopy images.
    Type of Medium: Online Resource
    Pages: X, 170 p. 69 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030223861
    Series Statement: Learning Materials in Biosciences,
    URL: https://doi.org/10.1007/978-3-030-22386-1
    DOI: 10.1007/978-3-030-22386-1
    DDC: 660.6
    Language: English
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  • 17
    Online Resource
    Online Resource
    Manual of Biobank Quality Management (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Biology Technique. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Biological Techniques. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Management of Biobanks -- Chapter 2. Quality Management -- Chapter 3. Documentation and Records -- Chapter 4. Human Resources Management -- Chapter 5. Ethical and Legal Aspects -- Chapter 6. Supplies, Materials Management -- Chapter 7. Equipment -- Chapter 8. Traceability -- Chapter 9. Environmental and Staff Hygiene -- Chapter 10. Biobanking Processes and Quality Control -- Chapter 11. Deviations, Nonconforming Product/Data or Service -- Chapter 12. Audits -- Chapter 13. Improvement -- Chapter 14. Biobank Cooperation in the Scientific, Research and Development Area -- Chapter 15. Safety and Security.
    Abstract: This pioneering handbook serves as an essential tool for any biobanking entity to create, implement and continuously improve their Quality Management System (QMS). Written in a concise and highly readable manner all biobanking related QMS aspects, ranging from legal aspects to safety matters, are addressed according to the best knowledge in compliance with the dedicated Biobanks ISO standards. Following a practical approach by making use of FAQ and common practice sections this book guides the readers through this complex field in an easy-to understand way. The guidelines are convergent not only with ISO 20387:2018 Biotechnology - Biobanking - General requirements for biobanking but also with ISO 9001:2015, ISO 19011:2018, ISO 27000:2014, and ISO 27002:2013. Furthermore, they are compatible, among others with the recommendations of the Organization for Economic Cooperation and Development (OECD), IARC, and ISBER Best Practices. Aimed at both biobank employees and other stakeholders (e.g. public bodies, political bodies, hospitals, pharmaceutical industry, funders) at any level of experience the book serves as valuable source for self-education and teaching. The manual complies to the principles of responsibility, openness, and transparency and can be used by any biobanking unit regardless of the biological material the biobank operates with and independent of their associated biobank network. On behalf of a group of specialists and experts in the area of biobanking, regarding Quality Management Systems (QMS), Ethical, Legal and Societal Issues (ELSI) and IT solutions, the authors present with this book a significant achievement based on activities within the project, European Research Infrastructure BBMRI-ERIC „Quality Standards for Polish Biobanks” Handbook (QSPB).
    Type of Medium: Online Resource
    Pages: XVII, 152 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031125591
    URL: https://doi.org/10.1007/978-3-031-12559-1
    DOI: 10.1007/978-3-031-12559-1
    DDC: 660.6
    Language: English
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  • 18
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    Online Resource
    'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Oncology. ; Medical genetics. ; Bioinformatics. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Oncology. ; Medical Genetics. ; Bioinformatics. ; Microsystems and MEMS.
    Description / Table of Contents: Module 1_ Introduction -- Module 2_ Cancer Metastasis -- Module 3_ Role of Transcriptomics in cancer treatment strategies -- Module 4_Computational approaches -- Module 5_Biostatistics and clinical oncology -- Module 6_Pharmacogenomics in cancer -- Chapter 7_Case studies.
    Abstract: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
    Type of Medium: Online Resource
    Pages: XVIII, 499 p. 59 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811510670
    URL: https://doi.org/10.1007/978-981-15-1067-0
    DOI: 10.1007/978-981-15-1067-0
    DDC: 571.978
    Language: English
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  • 19
    Online Resource
    Online Resource
    Diseases of the Breast during Pregnancy and Lactation (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Human physiology. ; Medicine Research. ; Biology Research. ; Gynecology . ; Cancer Biology. ; Human Physiology. ; Biomedical Research. ; Gynecology.
    Description / Table of Contents: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.
    Abstract: Symptoms of the breast in gravid women commonly represent physiological changes, however they may also be related to serious underlying breast disease; this challenging dilemma is aggravated by diagnostic and therapeutic limitations imposed by safety issues regarding the mother and fetus. A comprehensive coverage of all aspects of normal and pathologic breast changes during pregnancy and lactation, their diagnosis and management is provided in the present work. The organized structure of this book begins with gestational changes of the breast, while discussing safety, hazards, and arguments regarding diagnostic approaches. It then goes on by describing various clinical presentations and common and uncommon benign disorders during gravidity. The book then addresses pre-malignant lesions of the breast, opening the dialogue on how to manage these confusing lesions in pregnant and nursing women. It continues toward pregnancy-associated breast cancer, focusing on every facet of the problem, including epidemiology, diagnosis, treatment and complications, anesthetic considerations, prenatal care, and rare malignancies; and comes to an end by arguing main psychological concerns. In the midst of this orderly sequence fertility issues, pregnancy, and breastfeeding in women who have overcome their breast cancer are also discussed. This unique reference has been written by academic experts from different centers and diverse disciplines in a practical format. It is intended to be an ideal resource for every practitioner and specialist who manages complaints of gravid and nursing women or treats breast disorders in women of child bearing age.
    Type of Medium: Online Resource
    Pages: XXV, 216 p. 55 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030415969
    Series Statement: Advances in Experimental Medicine and Biology, 1252
    URL: https://doi.org/10.1007/978-3-030-41596-9
    DOI: 10.1007/978-3-030-41596-9
    DDC: 571.978
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  • 20
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    Online Resource
    Circulating Tumor Cells in Breast Cancer Metastatic Disease (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Stem cells. ; Cancer Biology. ; Biomedical Research. ; Biotechnology. ; Stem Cell Biology.
    Description / Table of Contents: Preface -- Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. .
    Abstract: This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.
    Type of Medium: Online Resource
    Pages: XV, 167 p. 15 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030358051
    Series Statement: Advances in Experimental Medicine and Biology, 1220
    URL: https://doi.org/10.1007/978-3-030-35805-1
    DOI: 10.1007/978-3-030-35805-1
    DDC: 571.978
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  • 21
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    Online Resource
    Biomedical Visualisation : Volume 6 (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Bioinformatics. ; Biotechnology. ; Computational and Systems Biology.
    Description / Table of Contents: Web-based 3D visualisation of biological and medical data -- Ultrasound-Guided Regional Anaesthesia: Visualising Nerve and Needle -- Scanning conditions in functional connectivity magnetic resonance imaging: how to standardise resting-state for optimal data acquisition and visualisation? -- Interactive VR Stroke Rehabilitation System Design -- Systematic review of Augmented and Virtual Reality in anatomical education -- Interdimensional travel: Visualisation of 3D-2D transitions in anatomy learning -- Anatomy Visualizations Using Stereopsis: Assessment and Implication of Stereoscopic Virtual Models in Anatomical Education -- Storyboarding in Medical Animation -- The hidden curriculum of imaging and utilisation of unregulated social media resources within clinical education -- Online distance learning in biomedical sciences: Community, belonging and presence. .
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. The first eight chapters examine a variety of tools, techniques, methodologies and technologies which can be utilised to visualise and understand biological and medical data. This includes web-based 3D visualisation, ultrasound, virtual and augmented reality as well as functional connectivity magnetic resonance imaging, storyboarding and a variety of stereoscopic and 2D-3D transitions in learning. The final two chapters examine the pedagogy behind digital techniques and tools from social media to online distance learning techniques.
    Type of Medium: Online Resource
    Pages: XV, 181 p. 69 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030376390
    Series Statement: Advances in Experimental Medicine and Biology, 1235
    URL: https://doi.org/10.1007/978-3-030-37639-0
    DOI: 10.1007/978-3-030-37639-0
    DDC: 660.6
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  • 22
    Online Resource
    Online Resource
    Novel therapeutic approaches for gastrointestinal malignancies (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Nanotechnology. ; Radiology. ; Molecular genetics. ; Cancer Biology. ; Nanotechnology. ; Radiology. ; Molecular Genetics.
    Description / Table of Contents: Chapter 1. Role of selected transcription factors in pancreatic and colorectal cancer growth and metastasis -- Chapter 2. Adiponectin in gastrointestinal malignancies -- Chapter 3. Small molecule-targeted therapies for GI cancers: success and failures -- Chapter 4. Epigenetic biomarkers for the detection of Gastrointestinal Cancers -- Chapter 5. CD151: A Lateral organizer and modulator of Tumor microenvironment in gastrointestinal cancers -- Chapter 6. Targeting Pathways in GI Malignancies -- Chapter 7. Identification of Potential Key Genes Involved In Progression of Gastric Cancer Using Bioinformatics Analysis -- Chapter 8. Recent Development in the biomarkers for the gastric cancer -- Chapter 9. Gastric Cancer and it’s remedy -- Chapter 10. An intergenic variant rs4779584 between SCG5 and GREM1 contributes to the increased risk of colorectal cancer: A meta-analysis -- Chapter 11. Phytochemicals plus nanomaterial’s on colorectal cancer -- Chapter 12. Pancreatic Ductal Adenocarcinoma and Type 2 Diabetes Mellitus: Distant Relatives or the Close Ones? -- Chapter 13. Tumor Biomarkers and Diagnosis of Pancreatic Adenocarcinoma -- Chapter 14. Immunotherapy in Gastrointestinal Malignancies -- Chapter 15. The Role of HIF-1α in Hepatocellular Carcinoma.
    Abstract: This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.
    Type of Medium: Online Resource
    Pages: XII, 259 p. 53 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811554711
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    URL: https://doi.org/10.1007/978-981-15-5471-1
    DOI: 10.1007/978-981-15-5471-1
    DDC: 571.978
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  • 23
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    Online Resource
    Industrial Applications of Glycoside Hydrolases (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Biotechnology. ; Enzymology. ; Proteins. ; Bioinformatics. ; Microbial genetics. ; Biotechnology. ; Enzymology. ; Proteins. ; Bioinformatics. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. Introduction to Glycoside Hydrolases: Classification, identification and Occurrence -- Chapter 2. Glycosyl Hydrolases – Biochemistry and Applications -- Chapter 3. Lignocellulolytic and Chitinolytic Glycoside Hydrolases: Structure, Catalytic -- Chapter 4. Role of glycosyl hydrolases in breakdown of lignocellulosic waste and its industrial applications -- Chapter 5. Marine glycosyl hydrolases as tool for industrial application -- Chapter 6. Glycosyl Hydrolases and Biofuel -- Chapter 7. Role of Glycoside hydrolases in pulp and paper industries -- Chapter 8. Application of glycosyl hydrolases in food industry -- Chapter 9. The effects of xylanase synergistic interactions during lignocellulose degradation and their significance for industry -- Chapter 10. Role of metagenomics in discovery of industrially important cellulase.
    Abstract: This book gathers selected studies on the industrial applications of glycoside hydrolases (GHs), presenting an updated classification of these enzymes, and discussing their structure, mechanisms, and various approaches to improve their catalytic efficiency. Further, it explains the various industrial applications of glycoside hydrolases in food, effluent treatment, biofuel production, and the paper and pulp industries. Lastly, the book provides a comparative analysis of glycosyide hydrolases and discusses the role of metagenomics in the discovery of industrially important enzymes. As such it is a thought-provoking, instructive and informative resource for biochemists, enzymologists, molecular biologists and bioprocess technologists. .
    Type of Medium: Online Resource
    Pages: XXI, 259 p. 35 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811547676
    URL: https://doi.org/10.1007/978-981-15-4767-6
    DOI: 10.1007/978-981-15-4767-6
    DDC: 660.6
    Language: English
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  • 24
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    Online Resource
    Molecular Biology of Human Cancers (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
    Abstract: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
    Type of Medium: Online Resource
    Pages: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031162862
    URL: https://doi.org/10.1007/978-3-031-16286-2
    DOI: 10.1007/978-3-031-16286-2
    DDC: 571.978
    Language: English
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    Advances in Nanochemoprevention : Controlled Delivery of Phytochemical Bioactives (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Nanotechnology. ; Pharmaceutical chemistry. ; Cancer. ; Biotechnology. ; Nanotechnology. ; Pharmaceutics. ; Cancer Biology.
    Description / Table of Contents: Introduction to chemoprevention -- Phytochemical Bioactives in Chemoprevention -- Controlled Delivery of Chemopreventive Agents -- Nanochemoprevention -- Targeted Nanomedicine in Chemoprevention -- Miscellaneous Approaches of Chemoprevention -- Quality Control, Scale Up and Regulatory Aspects Of Herbal Nanomedicine.
    Abstract: This book discusses the recent progress and advances in nanochemoprevention. Chemoprevention utilizes natural dietary compounds and has regained interest due to larger safety window and proven efficacy of such molecules in cancer treatments. Nanotechnology has revolutionized drug delivery through passive as well as active targeting. This book provides a comprehensive overview of phytochemical bioactives that are used in chemoprevention. It gives a comprehensive overview of the variety of natural molecules and types of nanoparticles as well as mechanistic aspects of their superior efficacy over plain drug molecules. The book concludes with summarizing the progress of pre-clinical results of developed formulations for cancer treatment using nano-chemoprevention.
    Type of Medium: Online Resource
    Pages: XI, 95 p. 16 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811596926
    URL: https://doi.org/10.1007/978-981-15-9692-6
    DOI: 10.1007/978-981-15-9692-6
    DDC: 660.6
    Language: English
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  • 26
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    Online Resource
    Inflammation, Infection, and Microbiome in Cancers : Evidence, Mechanisms, and Implications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cancer Biology. ; Medical Microbiology. ; Biomedical Research. ; Human Physiology. ; Immunology.
    Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.
    Abstract: This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.
    Type of Medium: Online Resource
    Pages: XII, 509 p. 31 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679514
    Series Statement: Physiology in Health and Disease,
    URL: https://doi.org/10.1007/978-3-030-67951-4
    DOI: 10.1007/978-3-030-67951-4
    DDC: 571.978
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  • 27
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    Online Resource
    Biomaterials in Tissue Engineering and Regenerative Medicine : From Basic Concepts to State of the Art Approaches (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Regenerative medicine. ; Stem cells. ; Nanotechnology. ; Biotechnology. ; Regenerative Medicine and Tissue Engineering. ; Stem Cell Biology. ; Nanotechnology.
    Description / Table of Contents: Module 1_Fundamentals of Biomaterials -- Module 2_Biomaterials in Tissue engineering -- Module 3_Applications of Biomaterials -- Module 4_Advances in Biomaterials.
    Abstract: This book comprehensively explores the basic concepts and applications of biomaterials in tissue engineering and regenerative medicine. The book is divided into four sections; the first section deals with the basic concepts and different types of biomaterials used in tissue engineering. The second section discusses the functional requirements and types of materials that are used in developing state-of-the-art of scaffolds for tissue engineering applications. The third section presents the applications of biomaterials for hard and soft tissue engineering, as well as for specialized tissue engineering. The last section addresses the future prospects of nanobiomaterials, intelligent biomaterials, and 3D bioprinting biomaterials in tissue engineering and regenerative medicine. It also discusses various in vitro disease models for tissue bioengineering and regenerative medicine. As such, it offers a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.
    Type of Medium: Online Resource
    Pages: IX, 589 p. 88 illus., 84 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811600029
    URL: https://doi.org/10.1007/978-981-16-0002-9
    DOI: 10.1007/978-981-16-0002-9
    DDC: 660.6
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  • 28
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    Online Resource
    Biotechnology Applied to Inflammatory Diseases : Cellular Mechanisms and Nanomedicine (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Cytology. ; Nanobiotechnology. ; Biology. ; Nanotechnology. ; Nanomedicine. ; Biotechnology. ; Cell Biology. ; Nanobiotechnology. ; Biological Sciences. ; Nanotechnology. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Part 1. Cellular and molecular mechanisms in inflammatory diseases -- Chapter 1. Vascular Diseases as mediator of systemic inflammation -- Chapter 2. Inflammation and gut microbiote -- Chapter 3. Cardioimmunology: na interdisciplinar approach -- Chapter 4. Cell therapy as strategy for respiratory Diseases -- Chapter 5. Mitochondrial dysfunction as a trigger of inflammation in cardiovascular diseases -- Chapter 6. Cancer therapy-induced inflammation and its consequences -- Chapter 7. Coupling glucose phosphorylation to oxygen in brain mitochondria: would it be redox set point? -- Chapter 8. Methods for the analysis of arachidonic acid-derived metabolites in platelets -- Part 2. Nanomedicines for inflammatory diseases -- Chapter 9. In vitro models and molecular markers for assessing nano-based systems inflammatory potential -- Chapter 10. Using micro- and nanocarriers for myocardial targeted delivery -- Chapter 11. Nano-based hydrogels for atopic dermatitis treatment -- Chapter 12. Nanomedicine applied to inflammatory bowel diseases -- Chapter 13. Nanomedicine therapies for macrophage-targeted delivery -- Chapter 14. Nano-based therapies for pulmonary inflammatory diseases -- Chapter 15. Pulmonary inflammation treated by nanocarriers.
    Abstract: Biotechnology involves an interdisciplinary science that provides an interface between biological, molecular and cellular aspects of living organisms with broad technologies applicable in the fields of health, environment and materials. This book “Biotechnology applied to inflammatory diseases: Cellular mechanisms and nanomedicine” is focused on elaborating especially on two trendy areas from Biotechnology. In this volume, different inflammatory pathologies in terms of cellular and molecular mechanisms are characterized to better understand the science behind current precision medicine. The second part of the book focuses on the main biotechnological advancements for the understanding of the molecular mechanisms involved in the progression of various types of inflammatory diseases, highlighting up-to-date contributions of nanomedicine. The reader will be able to explore the utilization of technologies for various inflammatory diseases and will be able to enable an engaging and valuable knowledge for further research and clinically applied scenarios. .
    Type of Medium: Online Resource
    Pages: IX, 340 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811983429
    Series Statement: Interdisciplinary Biotechnological Advances,
    URL: https://doi.org/10.1007/978-981-19-8342-9
    DOI: 10.1007/978-981-19-8342-9
    DDC: 660.6
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    Pharmaceutical Nanobiotechnology for Targeted Therapy (2022)
    Cham :Springer International Publishing :
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    Keywords: Biotechnology. ; Biology Technique. ; Molecular biology. ; Nanotechnology. ; Biotechnology. ; Biological Techniques. ; Molecular Biology. ; Nanotechnology.
    Description / Table of Contents: Preface -- Chapter. 1. Outer Membrane Vesicles (OMVs) as a Platform for Vaccination and Targeted Drug Delivery -- Chapter. 2. CRISPR/Cas9 Nano-Delivery Approaches for Targeted Gene Therapy -- Chapter. 3. Lipoplexes and Polyplexes for Targeted Gene Delivery -- Chapter. 4. Aptamer-Based Targeted Drug Delivery Systems -- Chapter. 5. Artificial Exosomes as Targeted Drug Delivery Systems -- Chapter. 6. Nanoarchaeosomes in drug delivery -- Chapter. 7. Bioengineered Metallic Nanomaterials for Nanoscale Drug Delivery Systems -- Chapter. 8. Nanobody-Based Delivery Systems for Diagnosis and Therapeutic Applications -- Chapter. 9. Phytosomes Used for Herbal Drug Delivery -- Chapter. 10. Porphysomes and porphyrin-based nanomaterials for drug delivery system -- Chapter. 11. Ethosomes for Dermal and Transdermal Drug Delivery Systems -- Chapter. 12. Liposomes and Niosomes for Targeted Drugs and Gene Delivery Systems -- Chapter. 13. Dendrimers as Targeted Systems for Selective Gene and Drug delivery -- Chapter. 14. Polymersomes for Targeted Drug and Gene Delivery Systems -- Chapter. 15. Quantum-Dot-Based Nanomaterials for Diagnostic and Therapeutic applications -- Chapter. 16. Carbon-based Nanomaterials for Targeted Drug and Gene Delivery Systems -- Chapter. 17. Hybrid Multifunctional Nanomaterials for Diagnostic and Therapeutic Applications -- Chapter. 18. Polymeric Micelles for Targeted Drug Delivery Systems -- Chapter. 19. Polymeric Nanoparticles for Targeted Drug and Gene Delivery Systems -- Chapter. 20. Magnetic Nanoparticles for Diagnostic and Therapeutic Applications.
    Abstract: The field of nanotechnology for targeted therapy initiated more than decade ago has grown fast and interest is increasing. Given the importance of the field for targeted drug and gene delivery systems, there are a large number of laboratory investigations today researching nanobiomaterials for diagnostic and therapeutic applications. Because of the ability of scientists to load nanoparticles with any agent, interest continues to grow and technology in this arena is rapidly evolving. These emerging nanobiomaterials-based medicines can overcome the disadvantages of traditional medicines by target-oriented and site-specific delivery of precise medicines (immunotherapeutic agents, chemotherapeutic agents, diagnostic agents, and so on). Pharmaceutical Nanobiotechnology for Targeted Therapy presents an updated overview of recent advancements in the field of pharmaceutical nanobiotechnology and nano-based drug and gene delivery systems. This comprehensive knowledge will allow researchers to discover innovative nanobiomaterials for targeted therapeutics. The chapters deal with various emerging nanobiomaterials for targeted therapeutic delivery systems and the writing is in a style that is easily disseminated and in a manner that can be readily adopted as sources for new and further studies. This book should be useful for researchers and professionals from academia and industry working in the field of nanotechnology, nanobiotechnology, as well as in the field of pharmaceutical nanotechnology. It should also be useful to those interested in a range of disciplines from material science, chemistry, molecular biology, polymer chemistry, and many more interdisciplinary areas.
    Type of Medium: Online Resource
    Pages: XIV, 639 p. 127 illus., 102 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031126581
    Series Statement: Nanotechnology in the Life Sciences,
    URL: https://doi.org/10.1007/978-3-031-12658-1
    DOI: 10.1007/978-3-031-12658-1
    DDC: 660.6
    Language: English
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    Online Resource
    Feature Engineering and Computational Intelligence in ECG Monitoring (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Computational intelligence. ; Bioinformatics. ; Biotechnology. ; Computational Intelligence. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Feature engineering and computational intelligence in ECG monitoring – an introduction -- Chapter 2. Representative Databases for Feature Engineering and Computational Intelligence in ECG Processing -- Chapter 3. An Overview of signal quality indices on dynamic ECG signal quality assessment -- Chapter 4. Signal quality features in dynamic ECGs -- Chapter 5. Motion Artifact Suppression Method in Wearable ECG -- Chapter 6. Data Augmentation for Deep Learning based ECG analysis -- Chapter 7. Study on Automatic Classification of Arrhythmias -- Chapter 8. ECG Interpretation with deep learning -- Chapter 9. Visualizing ECG contribution into Convolutional Neural Network classification -- Chapter 10. Atrial fibrillation detection in dynamic signals -- Chapter 11. Applications of Heart rate variability in Sleep Apnea -- Chapter 12. False Alarm Rejection for ICU ECG Monitoring -- Chapter 13. Respiratory Signal Extraction from ECG Signal -- Chapter 14. Noninvasive Recording of Cardiac Autonomic Nervous Activity--What’s behind ECG? -- Chapter 15. A questionnaire study on artificial intelligence and its effects on individual health and wearable device.
    Abstract: This book discusses feature engineering and computational intelligence solutions for ECG monitoring, with a particular focus on how these methods can be efficiently used to address the emerging challenges of dynamic, continuous & long-term individual ECG monitoring and real-time feedback. By doing so, it provides a “snapshot” of the current research at the interface between physiological signal analysis and machine learning. It also helps clarify a number of dilemmas and encourages further investigations in this field, to explore rational applications of feature engineering and computational intelligence in ECG monitoring. The book is intended for researchers and graduate students in the field of biomedical engineering, ECG signal processing, and intelligent healthcare.
    Type of Medium: Online Resource
    Pages: X, 268 p. 101 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811538247
    URL: https://doi.org/10.1007/978-981-15-3824-7
    DOI: 10.1007/978-981-15-3824-7
    DDC: 660.6
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  • 31
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    Regulation of Cancer Immune Checkpoints : Molecular and Cellular Mechanisms and Therapy (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Immunology. ; Biomedical Research.
    Description / Table of Contents: Introduction -- Molecular and cellular functions of CTLA-4 pathway -- Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond -- Discovery of new immune checkpoints: family grows up -- Mechanisms of resistance to checkpoint blockade therapy -- Molecular events behind adverse effects -- Rational discovery of response biomarkers -- Spatiotemporal changes in checkpoint molecule expression -- Functions of checkpoint molecules beyond immune evasion -- Genetic alterations and checkpoint expression -- Regulations on messenger RNA: wires and nodes -- Folded or degraded in endoplasmic reticulum -- Mono- and poly-ubiquitination: tags for fates -- Lysosome as the black hole for checkpoint molecules -- Phosphorylation: a fast switch for checkpoint signalling -- Palmitoylation as a signal for delivery -- Checkpoints under traffic control: from and to organelles -- Exosome and secretion: action on? -- Macromolecules and antibody-based drugs -- Mechanisms inspired targeting peptides -- Small molecular inhibitors -- Therapeutic development of immune checkpoint blockers -- Concluding remarks.
    Abstract: This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
    Type of Medium: Online Resource
    Pages: X, 653 p. 105 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811532665
    Series Statement: Advances in Experimental Medicine and Biology, 1248
    URL: https://doi.org/10.1007/978-981-15-3266-5
    DOI: 10.1007/978-981-15-3266-5
    DDC: 571.978
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    Biomedical Visualisation : Volume 7 (2020)
    Cham :Springer International Publishing :
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    Keywords: Biotechnology. ; Bioinformatics. ; Biotechnology. ; Computational and Systems Biology.
    Description / Table of Contents: Virtual Anatomy Museum – Facilitating Public Engagement Through An Interactive Application -- E-Learning And Embryology; Designing An Application To Improve 3D Comprehension Of Embryological Structures -- Animated Guide to Represent A Novel Means of Gut-brain Axis Communication -- Engaging with Children using Augmented Reality on Clothing to Prevent them from Smoking -- Enabling More Accessible MS Rehabilitation Training Using Virtual Reality -- The Use of Augmented Reality to Raise Awareness of the Differences between Osteoarthritis and Rheumatoid Arthritis -- Understanding the Brain and Exploring the Effects of Clinical Fatigue: From A Patient’s Perspective -- A Methodology for Visualising Growth and Development of the Human Temporal Bone -- Collect the Bones, Avoid the Cones: A Game-Based App for Public Engagement -- A Serious Game on Skull Anatomy for Dental Undergraduates. .
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. All chapters in this volume feature collaborative and innovative postgraduate research projects from graduate students of the MSc Medical Visualisation and Human Anatomy. This pioneering, world-leading postgraduate taught degree program is a joint partnership degree between the School of Life Sciences within the College of Medical, Veterinary and Life Sciences in the University of Glasgow, and the School of Simulation and Visualisation, The Glasgow School of Art. These chapters truly showcase the amazing and diverse technological applications that have been carried out as part of their research projects.
    Type of Medium: Online Resource
    Pages: XVI, 237 p. 268 illus., 238 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030439613
    Series Statement: Advances in Experimental Medicine and Biology, 1262
    URL: https://doi.org/10.1007/978-3-030-43961-3
    DOI: 10.1007/978-3-030-43961-3
    DDC: 660.6
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    Online Resource
    Pharmacotherapeutic Botanicals for Cancer Chemoprevention (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Medical genetics. ; Pharmaceutical chemistry. ; Bioinformatics. ; Cancer Biology. ; Medical Genetics. ; Pharmaceutics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Phytochemicals in Cancer Chemoprevention: A Brief Perspective -- Chapter 2. Phytochemicals in Modulating Signalling Cascades in Cancer Cells -- Chapter 3. Diverse cancer therapeutic interactions: complexities in cancer management -- Chapter 4. Natural Products as Chemosensitizers for Adjunct Therapy in Cancer Management -- Chapter 5. Dietary phytochemicals as epigenetic modulators in cancer prevention: Emerging research trends, gaps, and future perspectives -- Chapter 6. Modulation of Cancer Cell Metabolism and Microenvironment by Phytochemicals -- Chapter 7. Role of Nutrigenetics and Nutrigenomics in Cancer Chemoprevention -- Chapter 8. Nano-delivery carriers for Enhanced Bioavailability of Antitumor Phytochemicals -- Chapter 9. Biphasic Effects of Phytochemicals and their Relevance to Cancer Therapeutics -- Chapter 10. Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention -- Chapter 11. 3 Dimensional Cell Culture Techniques in Cancer Research -- Chapter 12. Animal Models Systems of Cancer for Preclinical Trials -- Chapter 13. Cancer Chemoprevention by Natural Plant Products and Their Derivatives: Clinical Trials.
    Abstract: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.
    Type of Medium: Online Resource
    Pages: XII, 337 p. 120 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811559990
    URL: https://doi.org/10.1007/978-981-15-5999-0
    DOI: 10.1007/978-981-15-5999-0
    DDC: 571.978
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    Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Molecular genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology. ; Cancer Biology. ; Molecular Genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology.
    Description / Table of Contents: Chapter 1. Potential Role of Biomarkers, Biosensors, Technologies and Computational Methods in Early Detection of Gastrointestinal Cancer -- Chapter 2. Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer -- Chapter 3. Development and Evaluation of Biomarkers for Early Detection of Cancer -- Chapter 4. Prognostic Molecular Markers for Gastrointestitinal cancer -- Chapter 5. Metabolic Markers for Early Detection of Gastrointestinal Cancer -- Chapter 6. Current Status of MicroRNA-based Biomarkers for Gastric Cancer -- Chapter 7. Genetic Susceptibility Markers of Gastrointestinal Cancer -- Chapter 8. Approaches For Early Detection Of Gastrointestinal Cancer -- Chapter 9. Biosensors and its Applications for Early Detection of Gastrointestitinal Cancer -- Chapter 10. Application of Nanotechnology in Early Detection of Gastrointestinal Cancer -- Chapter 11. Genetic Marker Identification for the Detection of Early-Onset Gastrointestitinal Cancer Through Genome Wide Association Studies -- Chapter 12. Big Data Analytics to Discover Diagnostics and Therapeutics for Gastrointestitinal Cancer -- Chapter 13. System Biology Approach for Early Prognosis of Gastrointestinal Cancer.
    Abstract: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XXIII, 231 p. 38 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811544316
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    URL: https://doi.org/10.1007/978-981-15-4431-6
    DOI: 10.1007/978-981-15-4431-6
    DDC: 571.978
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    Models, Molecules and Mechanisms in Biogerontology : Cellular Processes, Metabolism and Diseases (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Geriatrics. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Bioinformatics. ; Regenerative medicine. ; Biotechnology. ; Geriatrics. ; Biomedical Research. ; Medical Genetics. ; Computational and Systems Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: PART I ~ ALTERATIONS IN CELLULAR MECHANISMS DURING AGING -- Chapter 1 Protein Structure and Function in Aging and Age-related Diseases -- Chapter 2 DNA, DNA Replication and Aging -- Chapter 3 Transcription and Aging -- Chapter 4 Ribosomes, Translation and Aging -- Chapter 5 p53 and Aging -- Chapter 6 Paired Box (Pax) Transcription Factors and Aging -- Chapter 7 Telomeres, Telomerase and Aging -- Chapter 8 The Epigenome of Ageing -- Chapter 9 Attaining Epigenetic Rejuvenation: Challenges Ahead -- Chapter 10 Mitochondria as a Key Player in Aging -- Chapter 11 Aging, Free Radicals and Reactive Oxygen Species: An Evolving Concept -- Chapter 12 Stem Cells and Aging -- Chapter 13 Can Autophagy Stop the Clock: Unravelling the Mystery in Dictyostelium discoideum -- Chapter 14 Aging: Reading, Reasoning and Resolving Using Drosophila as a Model System -- Chapter 15 Nothobranchius furzeri as a New Model System for Aging Studies -- PART II ALTERATIONS IN METABOLISM DURING AGING AND DISEASES -- Chapter 16 Aging in Muscle -- Chapter 17 Metabolic Diseases and Aging -- Chapter 18 Interplay Between Nutrient Sensing Molecules During Aging and Longevity -- Chapter 19 Protein Aggregation, Related Pathologies and Aging -- Chapter 20 Biological Rhythms and Aging -- Chapter 21 The Biology of Ageing and Cancer – A Complex Association.
    Abstract: The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.
    Type of Medium: Online Resource
    Pages: XIII, 497 p. 77 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813290051
    URL: https://doi.org/10.1007/978-981-32-9005-1
    DOI: 10.1007/978-981-32-9005-1
    DDC: 660.6
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  • 36
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    Online Resource
    Cancer Metabolomics : Methods and Applications (2021)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. NMR-Based Metabolomics in Cancer Research -- 2. Capillary Electrophoresis–Mass Spectrometry for Cancer Metabolomics -- 3. Chemical Isotope Labeling LC-MS for Metabolomics -- 4. Single cell metabolomics by mass spectrometry imaging -- 5. Fatty Acid Metabolism and Cancer -- 6. Metabolomics of Gastric Cancer -- 7. HIF-1α metabolic pathways in human cancer -- 8. Regulation of glycolysis in head and neck cancer -- 9. Metabolomics of oral/head and neck cancer -- 10. Ion chromatography with mass spectrometry for metabolomic analysis -- 11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids -- 12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy -- 13. Metabolomics of glioma -- 14. Microbial metabolomics: From methods to translational applications -- 15. Advances in the study of N6-methyladenine in eukaryotes -- 16. NMR Based Metabolomics -- 17. Quantitative analysis of oncometabolite 2-hydroxyglutarate -- 18. Tracer-based Cancer Metabolomic Analysis -- 19. Mass spectrometry-based shotgun lipidomics for cancer research -- 20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics.
    Abstract: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
    Type of Medium: Online Resource
    Pages: XV, 312 p. 80 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030516529
    Series Statement: Advances in Experimental Medicine and Biology, 1280
    URL: https://doi.org/10.1007/978-3-030-51652-9
    DOI: 10.1007/978-3-030-51652-9
    DDC: 571.978
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    Online Resource
    Signal and Image Processing Techniques for the Development of Intelligent Healthcare Systems (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Biotechnology. ; Bioinformatics. ; Computer vision. ; Machine learning. ; Biotechnology. ; Bioinformatics. ; Computer Vision. ; Machine Learning.
    Description / Table of Contents: Chapter 1. An Integrated Design of Fuzzy C-Means and NCA based Multi-Properties Features Reduction for Brain Tumor Recognition -- Chapter 2. Hybrid Image Processing based Examination of 2D Brain MRI Slices to Detect Brain Tumour/Stroke Section – A Study -- Chapter 3. Edge Enhancing Coherence Diffusion Filter for Level Set Segmentation and Asymmetry Analysis using Curvelets in Breast Thermograms -- Chapter 4. Lung Cancer Diagnosis Based on Image Fusion and prediction using CT and PET image -- Chapter 5. Segmentation and Validation of Infrared Breast Images using Weighted Level Set and Phase Congruency Edge Map Framework -- Chapter 6. Analysis of Material Profile for Polymer Based Mechanical Microgripper for Thin Plate Holding -- Chapter 7. Design and Testing of Elbow Actuated Wearable Robotic Arm for Muscular Disorders -- Chapter 8. A Comprehensive Study of Image Fusion Techniques and Their Applications -- Chapter 9. Multilevel Mammogram Image Analysis for Identifying Outliers, Misclassification using Machine Learning -- Chapter 10. A Review on Automatic Detection of Retinal Lesions in Fundus Images for Diabetic Retinopathy -- Chapter 11. Medical Image Watermarking: A Review on Wavelet Based Methods -- Chapter 12. EEG Signal Extraction Analysis Techniques -- Chapter 13. Classification of sEMG Signal based Arm Action using Convolutional Neural Network -- Chapter 14. An Automated Approach for the Identification of TB Images Enhanced by Non-uniform Illumination Correction.
    Abstract: This book comprehensively reviews the various automated and semi-automated signal and image processing techniques, as well as deep-learning-based image analysis techniques, used in healthcare diagnostics. It highlights a range of data pre-processing methods used in signal processing for effective data mining in remote healthcare, and discusses pre-processing using filter techniques, noise removal, and contrast-enhanced methods for improving image quality. The book discusses the status quo of artificial intelligence in medical applications, as well as its future. Further, it offers a glimpse of feature extraction methods for reducing dimensionality and extracting discriminatory information hidden in biomedical signals. Given its scope, the book is intended for academics, researchers and practitioners interested in the latest real-world technological innovations.
    Type of Medium: Online Resource
    Pages: XIV, 283 p. 117 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811561412
    URL: https://doi.org/10.1007/978-981-15-6141-2
    DOI: 10.1007/978-981-15-6141-2
    DDC: 660.6
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  • 38
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    Online Resource
    Emerging Trends in Nanomedicine (2021)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Microsystems and MEMS.
    Description / Table of Contents: Chapter 1. Strategies to improve oral delivery of natural anticancer molecules -- Chapter 2. Nanoparticles catalyzing enzymatic reactions: recent developments and future prospects -- Chapter 3. Biogenic silver nanoparticles: A potent therapeutic agent -- Chapter 4. Translational studies of nanofibers-based scaffold for skin and bone tissue regeneration -- Chapter 5. Functional Dendritic Coatings for Biomedical Implants -- Chapter 6. Application of nanotherapeutics for combating human protozoan parasitic infections.
    Abstract: This book illustrates the significance of nanotechnology in the delivery of anticancer and antimicrobial drugs, biomimetic technologies, tissue engineering, sensing, diagnostics, and artificial enzymes. It first briefly discusses the use of nanotechnology for the delivery of anticancer medications, and the concept and applications of catalytically active nanomaterial-based artificial enzymes for sensing and diagnostic applications. It then explores the use of silver nanoparticle-based novel antimicrobials, and comprehensively reviews the role of nanomaterials in developing biomedical implants and tissue engineering applications. Lastly, it offers a detailed description of nanotherapeutics for combating human protozoan parasitic infections. Cutting across the disciplines, this book serves as a guide for researchers and scientists in biotechnology, medical science and material science.
    Type of Medium: Online Resource
    Pages: XIV, 240 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811599200
    URL: https://doi.org/10.1007/978-981-15-9920-0
    DOI: 10.1007/978-981-15-9920-0
    DDC: 571.978
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  • 39
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    Online Resource
    Application of Nanotechnology in Biomedical Sciences (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Biotechnology. ; Nanotechnology. ; Cancer. ; Nanochemistry. ; Pollution. ; Biotechnology. ; Nanotechnology. ; Cancer Biology. ; Nanochemistry. ; Pollution.
    Description / Table of Contents: Chapter 1: Advancements of nanotechnology in diagnostic applications -- Chapter : 2: Polycaprolactone-based nanofibers and their in-vitro and in-vivo applications in bone tissue engineering -- Chapter 3: Nanocamptothecins as new generation pharmaceuticals for treatment of diverse cancers: Overview on a Natural product to Nanomedicine. – Chapter 4: Smart biomaterials from electrospun chitosan nanofibers by functionalization and blending in biomedical applications -- Chapter 5: Unique properties of the gold nanoparticles: Synthesis, functionalization and applications -- Chapter 6 : Nanotechnology and diabetes management: Recent advances and future perspectives -- Chapter 7: Recent advances in the emergence of nanorobotics in medicine -- Chapter 8: Composite of ceramic and polymeric nanofibers for photocatalytic degradation of dairy effluent.
    Abstract: This book highlights the wide applications of nanomaterials in healthcare and environmental remediation. Presenting nano-based materials that positively influence the growth and proliferation of cells present in soft and hard tissue and are used for the regeneration bone tissue and/or suppression of cancer cells, it also discusses the natural products that can be incorporated in nanofibers for the treatment of cancer. Further, it describes the use of blending and functionalization to produce chitosan nanofibers for biomedical applications, and reviews the role of plasma-enhanced gold nanoparticles in diagnostics and therapeutics. Lastly, the book also introduces various nanotechnology approaches for the removal of waste metabolites in drinking water, and explores the emerging applications of nanorobotics in medicine. Given its scope, this book is a valuable resource for scientists, clinicians, engineers and researchers aiming to gain a better understanding of the various applications of nanotechnology.
    Type of Medium: Online Resource
    Pages: XIV, 164 p. 63 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811556227
    URL: https://doi.org/10.1007/978-981-15-5622-7
    DOI: 10.1007/978-981-15-5622-7
    DDC: 660.6
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  • 40
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    The Future of Prevention and Treatment of Breast Cancer (2021)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. Defining breast cancer -- 2: Breast Cancer Recurrence and Survival -- 3: Synopsis of the Treatment of Breast Cancer -- 4: The Present Treatment of Hereditary Breast Cancer -- 5: Basis for the Epigenetic Treatment of Triple Negative Breast Cancer -- 6: A New Treatment Strategy foe BRCA1 Related Breast Cancer -- 7: Present Options in the Prevention of Breast Cancer -- 8: The Physiological Basis of Breast Cancer Prevention -- 9: The Present and Future of Screening in Breast Cancer Prevention -- 10: A Vision of the Future.
    Abstract: The objective of this book is to provide a critical analysis of the present prevention strategies for breast cancer, emphasizing the cost benefits and quality of life of the patient. Rooted in the present knowledge of breast cancer biology and prevention and treatment options, the book will describe the future tools that could be available to oncologists and how these new approaches may change the landscape of recurrence and survival of the disease. Special emphasis will be given to the prevention strategies counterposing the present limitations and conflicting prevention guidelines for both hereditary and preventive non-hereditary breast cancer, and propose how the implementation of new strategies based on the present knowledge could save millions of lives and be more cost efficient. The book will present a critical status of the treatment and prevention of breast cancer and detail how a quantum leap could be achieved in the field by applying present basic research knowledge to clinical application.
    Type of Medium: Online Resource
    Pages: XI, 192 p. 41 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030728151
    URL: https://doi.org/10.1007/978-3-030-72815-1
    DOI: 10.1007/978-3-030-72815-1
    DDC: 571.978
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  • 41
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    Online Resource
    Bio-Nano Interface : Applications in Food, Healthcare and Sustainability (2022)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Nanotechnology. ; Medicine Research. ; Biology Research. ; Industrial microbiology. ; Pharmaceutical chemistry. ; Biotechnology. ; Nanotechnology. ; Biomedical Research. ; Industrial Microbiology. ; Pharmaceutics.
    Description / Table of Contents: Chapter 1.Impact of isotropic and anisotropic plasmonic metal nanoparticles on healthcare and food-safety management -- Chapter 2. An introduction to different methods of nanoparticles synthesis -- Chapter 3. Classification, Synthesis, and Application of Nanoparticles against Infectious Diseases -- Chapter 4. Nanotechnology in Food Science -- Chapter 5. Facets of Nanotechnology in food processing, packaging and safety: an emerald insight -- Chapter 6. Nanotechnology and its potential application in postharvest technology -- Chapter 7. Nanotechnology mediated detection and control of phytopathogens -- Chapter 8. Nanosystems for Cancer Therapy -- Chapter 9. Phytoplankton mediated nanoparticles for cancer therapy. Chapter 10. Nanotechnology and its potential implications in Ovary Cancer -- Chapter 11. Nanotechnology: An Emerging Field in Protein Aggregation and Cancer Therapeutics -- Chapter 12. Bio-nano interface and its potential application in Alzheimer’s disease -- Chapter 13. Potential of curcumin nanoparticles in tuberculosis management -- Chapter 14. Application of Nanobiosensor in Health care sector -- Chapter 15. Bioactive nanoparticles: A next generation smart nanomaterials for pollution abatement and ecological sustainability -- Chapter 16. Smart nano-materials for bio-imaging applications:An overview -- Chapter 17. Biology of Earthworm in a World of Nano-materials: New Room, Challenges and, Future Perspectives -- Chapter 18. Bioethanol production from agricultural wastes with the aid of nanotechnology -- Chapter 19. Nanotechnology for sustainable bioenergy production.
    Abstract: This book discusses the unique interactions of nanoparticles with various biomolecules under different environmental conditions. It describes the consequences of these interactions on other biological aspects like flora and fauna of the niche, cell proliferation, etc. The book provides information about the novel and eco-friendly nanoparticle synthesis methods, such as continuous synthesis of nanoparticles using microbial cells. Additionally, the book discusses nanoparticles' potential impact in different areas of biological sciences like food, medicine, agriculture, and the environment. Due to their advanced physicochemical properties, nanoparticles have revolutionized biomedical and pharmaceutical sciences. Inside the biological milieu, nanoparticles interact with different moieties to adopt stable shape, size, and surface functionalities and form nano-biomolecular complexes. The interaction pattern at the interface form complexes determines the fate of interacting biomolecules and nanoparticles inside the biological system. Understanding the interaction pattern at the nano-bio interface is crucial for the safe use of nanoparticles in natural sciences. This book rightly addresses all questions about the interaction and the ensuing structure and function of these nano-biomolecular complexes. This book caters to students and researchers in the area of biotechnology, microbiology, and pharmaceutical sciences.
    Type of Medium: Online Resource
    Pages: IX, 355 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811625169
    URL: https://doi.org/10.1007/978-981-16-2516-9
    DOI: 10.1007/978-981-16-2516-9
    DDC: 660.6
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    Machine Learning in Biological Sciences : Updates and Future Prospects (2022)
    Singapore :Springer Nature Singapore :
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    Keywords: Biotechnology. ; Bioinformatics. ; Machine learning. ; Biotechnology. ; Computational and Systems Biology. ; Machine Learning. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. A Brief Overview Of Applications Of Machine Learning In Life Sciences -- Chapter 2. Introduction To Artificial Intelligence (Ai) Methods In Biology -- Chapter 3. Machine Learning Methods -- Chapter 4. Introduction To Machine Learning Models -- Chapter 5. Model Selection Formachine Learning -- Chapter 6. Multivariate Methods In Machine Learning In The Context Of Biological Data -- Chapter 7. Dimensionality Reduction Methods In Machine Learning -- Chapter 8. Hidden Markov Method -- Chapter 9. Neural Network And Deep Learning. Chapter 10. Ethics In Machine Learning And Artificial Intelligence -- Chapter 11. Machine Learning And Life Sciences -- Chapter 12. Machine Learning And Negleced Tropical Diseases- Chapter 13. Machine Learning In Cardiovascular Diseases -- Chapter 14. Machine Learning And Diabetes -- Chapter 15. Machine Learning And Epilepsy -- Chapter 16. The Microsoft, Google, Facebook, Pytorch And Applications In Biology -- Chapter 17. Applications And Software Of Machine Learning And Ai In Medical Knowledge In Health -- Chapter 18. Cloud Computing Infrastructure In Healthcare Industry -- Chapter 19. Amazon Web Services (Aws) And Microsoft Azure In The Domain Of Life Sciences -- Chapter 20. Toxicity: An Introduction -- Chapter 21. Machine Learning (Ml) And Toxicity Studies. Chapter 22. Applications Of Machine Learning In Study Of Cell Biology -- Chapter 23. Genomics And Machine Learning -- Chapter 24. Cell Fate Analysis And Machine Learning -- Chapter 25. Study Of Biomarker And Machine Learning -- Chapter 26. Animal Behaviour: An Introduction -- Chapter 27. Study Of Animal Behaviour And Machine Learning -- Chapter 28. Machine Learning And Precision Farming -- Chapter 29. Machine Learning In The Study Of Animal Health And Veterinary Sciences -- Chapter 30. Macinelearning And Animalresorviors -- Chapter 31. Challenging Problems In Plant Biology -- Chapter 32. Machine Learning And Plant Sciences. Chapter 33. Machine Learning In Understanding Of Plant Pathogen Interactions -- Chapter 34. Machine Learning In Plant Disease Research -- Chapter 35. Biorobots -- Chapter 36. The Challenges To Application Of Machine Learning In Biological Sciences -- Chapter 37. The Future Of Machine Learning.
    Abstract: This book gives an overview of applications of Machine Learning (ML) in diverse fields of biological sciences, including healthcare, animal sciences, agriculture, and plant sciences. Machine learning has major applications in process modelling, computer vision, signal processing, speech recognition, and language understanding and processing and life, and health sciences. It is increasingly used in understanding DNA patterns and in precision medicine. This book is divided into eight major sections, each containing chapters that describe the application of ML in a certain field. The book begins by giving an introduction to ML and the various ML methods. It then covers interesting and timely aspects such as applications in genetics, cell biology, the study of plant-pathogen interactions, and animal behavior. The book discusses computational methods for toxicity prediction of environmental chemicals and drugs, which forms a major domain of research in the field of biology. It is of relevance to post-graduate students and researchers interested in exploring the interdisciplinary areas of use of machine learning and deep learning in life sciences.
    Type of Medium: Online Resource
    Pages: XXI, 336 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811688812
    URL: https://doi.org/10.1007/978-981-16-8881-2
    DOI: 10.1007/978-981-16-8881-2
    DDC: 660.6
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    Drugs and a Methodological Compendium : From bench to bedside (2023)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Drug delivery systems. ; Biology. ; Pharmaceutical chemistry. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Drug Delivery. ; Biological Sciences. ; Pharmaceutics. ; Biomedical Research.
    Description / Table of Contents: Chapter 1.Computational and informatics methodologies in Drug Discovery, with focus on Natural Products -- Chapter 2.Structural biology an essential tool for Drug discovery and Development -- Chapter 3.Bioactivity guided fractionation and identification of bioactive molecules: A basic method in drug discovery -- Chapter 4.In–vitro methodologies for the safety assessment of drugs -- Chapter 5.In-vivo models for evaluation of Drug efficacy: Demand and Challenges -- Chapter 6.Preclinical In vivo Drug Development Studies: Limitations, Model Organisms and Techniques -- Chapter 7.Peptide Based Therapeutics and Drug Delivery Systems -- Chapter 8.Basics of Clinical Drug Development: Clinical Trial and Drug Development -- Chapter 9.Trailblazing contemporary frameworks for drug repurposing: A saga on drugs’ expedition to disinter the veiled destiny -- Chapter 10.Small molecules as promising tool for targeted cancer therapies: an overview of 21st century -- Chapter 11.Nanoparticles for Targeted Drug Delivery Systems with Cancer Therapy in Perspective -- Chapter 12.Biomimetic approach for the controlled drug delivery through 3D bioactive scaffolds: A novel strategy for tissue engineering applications -- Chapter 13.Perspectives on anti-tuberculosis drug discovery -- Chapter 14.Cofactor-Receptor interactions based pharmacophore design for development of novel inhibitors: A case study against Tuberculosis -- Chapter 15.Insilico identification of potential antivirals against SARS-CoV2 main protease and RBD of spike protein – A Drug Repurposing Approach -- Chapter16.Anti-malarial drug discovery and development: from bench to bedside.
    Abstract: This book provides a meticulous view on methodological drug discovery and development insights from bench to bedside. The current book threads almost each step encompassing drug the discovery and development of a molecule. The chapters focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. The book also covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines. .
    Type of Medium: Online Resource
    Pages: XV, 425 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811979521
    URL: https://doi.org/10.1007/978-981-19-7952-1
    DOI: 10.1007/978-981-19-7952-1
    DDC: 660.6
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    Tumor Microenvironment : The Main Driver of Metabolic Adaptation (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Immunology. ; Human physiology. ; Cytology. ; Cancer Biology. ; Biomedical Research. ; Medical Genetics. ; Immunology. ; Human Physiology. ; Cell Biology.
    Description / Table of Contents: Preface -- Tumor microenvironment a job of several holders -- Tumor microenvironment- a selective pressure boosting cancer -- Lactate and lactate transporters as key players in the maintenance of the Warburg effect -- Section 1. Adaptive metabolic features are sustained by tumor microenvironment -- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis -- Gut microbiota and cancer of the host: colliding interests -- Metabolic plasticity of tumor cells: how they do adapt to food deprivation -- Multifaceted oncogenic role of adipocytes in the tumour microenvironment -- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology -- Monocytes and macrophages in cancer: unsuspected roles -- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression -- Microenvironment driven metabolic adaptation in melanoma -- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis -- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt -- The bone marrow niche - the tumor microenvironment that ensures leukemia progression -- Section 3. Metabolic fitness and therapy response in cancer -- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer -- The metabolic remodelling in lung cancer and its putative consequence in therapy response -- Hydrogen sulfide metabolism and signaling in the tumor microenvironment -- Using metabolic adaptation to design new drugs -- Metabolomics- a new way of screening cancer -- NMR as a tool for metabolomics -- Section 5. Animal models- addressing cancer microenvironment -- Animal models to study cancer and its microenvironment -- Modulating the metabolic phenotype of cancer microenvironment -- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae -- Section 6. In vitro and ex vivo cancer models -- In vitro and ex vivo models- the tumor microenvironment in a flask -- Index.
    Abstract: This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.
    Type of Medium: Online Resource
    Pages: VII, 443 p. 63 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030340254
    Series Statement: Advances in Experimental Medicine and Biology, 1219
    URL: https://doi.org/10.1007/978-3-030-34025-4
    DOI: 10.1007/978-3-030-34025-4
    DDC: 571.978
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  • 45
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    Online Resource
    Cancer Cell Metabolism: A Potential Target for Cancer Therapy (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Chapter 1: Cancer cell metabolism: Solid tumor vs non-solid tumor -- Chapter 2: Reprogramming of cancer cell metabolism: Warburg and Reverse Warburg hypothesis -- Chapter 3: Molecular aspects of cancer cell metabolism: Altered glycolysis and lipid metabolism -- Chapter 4: Understanding the metabolic cross-talk between cancer cells and cancer-associated fibroblasts -- Chapter 5: Metabolic cross-talk between cancer cells and tumor microenvironment -- Chapter 6: Role of autophagy in cancer cell metabolism -- Chapter 7: Role of c-Met/HGF axis in altered cancer metabolism -- Chapter 8: Recent advances in drug development targeting cancer metabolism -- Chapter 9: Clinical relevance of “Diagnostic markers” in cancer metabolism -- Chapter 10: Alterations in Metabolite-driven Gene Regulation in Cancer Metabolism -- Chapter 11: Role of Phytochemicals in Cancer Cell Metabolism Regulation.
    Abstract: This book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.
    Type of Medium: Online Resource
    Pages: XIII, 184 p. 29 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811519918
    URL: https://doi.org/10.1007/978-981-15-1991-8
    DOI: 10.1007/978-981-15-1991-8
    DDC: 571.978
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  • 46
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    Advances in Bioengineering (2020)
    Singapore :Springer Nature Singapore :
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    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Proteins. ; Bioinformatics. ; Human physiology. ; Biotechnology. ; Biomedical Research. ; Proteins. ; Bioinformatics. ; Human Physiology.
    Description / Table of Contents: Chapter 1. Modeling of protein complexes involved in signaling pathway for Non-Small Cell Lung Cancer -- Chapter 2. Role of BioJava in the Department of Bioinformatics Tools -- Chapter 3. Overview of machine learning methods in ADHD prediction -- Chapter 4. Simplified Protein Structure Prediction Using Parallel Genetic Algorithms -- Chapter 5. Applications of deep learning in drug discovery -- Chapter 6. Big Data Analytics for Handling NGS Data & its Applications in Identifying Cancer Mutations -- Chapter 7. Medicinal Properties of Fruit waste -- Chapter 8. Epigenetic toxicity of nanoparticles -- Chapter 9. Protein Misfolding and Aggregation in Neurodegenerative diseases -- Chapter 10. Enzyme technology prospectus & their Biomedical Applications -- Chapter 11. Polyunsaturated fatty acids enhance the recovery of bone marrow impairment caused after radiation -- Chapter 12. Nanomaterial Enabled Rapid Electrochemical Biosensors For Bacterial Pathogens -- Chapter 13. Heart Rate Variability Analysis in lung cancer patients to study the effect of treatment -- Chapter 14. Co-Relation of Physiological Signals And Therapy for Diagnostics Purpose of Periodic Limb Movement Disorder (Plmd) -- Chapter 15. Analysis of Forward Head Posture -- Chapter 16. Biopolymeric Smart Nano-Carriers for Drug Delivery Applications.
    Abstract: This book provides a single source of information on three major bioengineering areas: engineering at the cellular and molecular level; biomedical devices / instrument engineering; and data engineering. It explores the latest strategies that are essential to advancing our understanding of the mechanisms of human diseases, the development of new enzyme-based technologies, diagnostics, prosthetics, high-performance computing platforms for managing huge amounts of biological data, and the use of deep learning methods to create predictive models. The book also highlights the growing importance of integrating chemistry into life sciences research, most notably concerning the development and evaluation of nanomaterials and nanoparticles and their interactions with biological material. The underlying interdisciplinary theme of bioengineering is addressed in a range of multifaceted applications and worked out examples provided in each chapter.
    Type of Medium: Online Resource
    Pages: XIII, 229 p. 79 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811520631
    URL: https://doi.org/10.1007/978-981-15-2063-1
    DOI: 10.1007/978-981-15-2063-1
    DDC: 660.6
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  • 47
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    Biotechnological Applications in Human Health (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Medical genetics. ; Molecular genetics. ; Medicine Research. ; Biology Research. ; Cancer. ; Biotechnology. ; Clinical Genetics. ; Molecular Genetics. ; Biomedical Research. ; Cancer Biology.
    Description / Table of Contents: Foreword -- Chapter 1: Design of Multi-wavelength Near Infra-Red probe to detect risk areas in diabetic foot -- Chapter 2: Cellular and molecular response for sensitising cancer cells and protecting the normal cells from radiation-induced damages -- Chapter 3: A Novel Approach for Production and Study of Medical Ultrasound from Low Cost Electromagnetic Transducers -- Chapter 4: Altered profile of regulatory T cells and NKT cells are characteristics of Chikungunya associated polyarthralgia -- Chapter 5: Cytotoxicity and Apoptosis of Human Colon Carcinoma Cell (HT 29 Cells), Treated with Methanolic Extract of Chlorococcum humicola -- Chapter 6: Universal primer design for the detection of diverged CTX-M Beta Lactamases (ESBL) that give penicillin and cephalosporin resistance during superbug infections -- Chapter 7: Lipopeptides as therapeutics: Molecular docking and drug design -- Chapter 8: Design and Simulation of Geometrical Shape and Size Variations of Micro-electrode for Cochlear Implant -- Chapter 9: Molecular and Protein Interaction Studies for Inhibiting Growth of Human Leukemic Cells: An In silico Structural Approach to Instigate Drug Discovery -- Chapter 10 -- Laccase Mediated Synthesis of Bio-material using Agro-residues -- Chapter 11: Extraction of Fungal Xylanase using ATPS-PEG/sulphate and its Application in Hydrolysis of Agricultural Residues -- Chapter 12: Thyme (Thymus vulgaris) essential oil based antimicrobial nanoemulsion formulation for fruit juice preservation.
    Abstract: This book compiles selected articles presented at the International Conference on Biotechnology & Biological Sciences, BIOSPECTRUM 2017, organized by the Department of Biotechnology, University of Engineering & Management, Kolkata. Focusing on biotechnology-based analysis and intervention to address certain human diseases, the book includes a holistic discourse on disease profiling, molecular level analysis of diseases, and non-invasive medical interventions. It features articles on non-invasive treatment of iron deficiency anemia with iron nanoparticles; novel diagnosis methods based on microarray data; analysis using machine learning techniques like artificial neural network for early detection and treatment of cancer; and drug discovery for preventing the growth of human leukemic cells. Further, the book sheds light on in silico drug design using lipopeptides, and identifying the binding sites for their corresponding ligands. Presenting the concepts of the design of potent and safe antimicrobial compounds to fight multi drug resistant pathogens, it also includes interesting reviews on the design and development of various non-invasive methods, such as multi NIR wavelength probes to identify the risk areas in the diabetic foot at an early stage; and a low-cost cochlear implant prototype designed and developed from commercial off the-shelf components to empower the hearing impaired. The book appeals to students, academics and researchers in a wide range of subject areas, including biotechnology, life sciences, medicine and cancer research.
    Type of Medium: Online Resource
    Pages: X, 114 p. 52 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811534539
    URL: https://doi.org/10.1007/978-981-15-3453-9
    DOI: 10.1007/978-981-15-3453-9
    DDC: 660.6
    Language: English
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  • 48
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    Online Resource
    Nanomaterial - Based Biomedical Applications in Molecular Imaging, Diagnostics and Therapy (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Biotechnology. ; Nanotechnology. ; Radiology. ; Human physiology. ; Biotechnology. ; Nanotechnology. ; Radiology. ; Human Physiology.
    Description / Table of Contents: Chapter 1. Nanomaterials: From research to personalized medicine -- Chapter 2. Introduction to molecular imaging, diagnostics and therapy -- Chapter 3. Biocompatible fluorescent nanomaterials for molecular imaging applications -- Chapter 4. Nanomaterials for Point of Care Disease Detection -- Chapter 5. Biomolecules immobilized nanomaterials and their biological applications -- Chapter 6. Lectin nanoconjugates for targeted therapeutic applications -- Chapter 7. Plant Based Polymeric Nanomaterials for Biomedical Applications -- Chapter 8. Nanomaterials at the biological interphase: Protein corona formation and infusion -- Chapter 9. Critical overview of the subject: Current scenario and future prospects. .
    Abstract: This book comprehensively reviews the recent advances in nanomaterial-based molecular imaging, diagnostics, and personalized therapy. It discusses the novel biocompatible fluorescent nanomaterials, their synthesis, and modern state of art characterization, as well as the various strategies for immobilization of biomacromolecules on the nanomaterial surface and approaches for increasing their stability. In addition, the book describes the synthesis of lectin nanoconjugates using different types of biocompatible raw materials and their systematic characterization. Lastly, it presents our current understanding of the biomolecular carona, which affects nanoparticle-based targeted drug delivery, and examines the conceptual approaches to improve the in-vivo efficacy of targeted drug delivery. .
    Type of Medium: Online Resource
    Pages: XIII, 203 p. 21 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811542800
    URL: https://doi.org/10.1007/978-981-15-4280-0
    DOI: 10.1007/978-981-15-4280-0
    DDC: 660.6
    Language: English
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  • 49
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    Online Resource
    Translational Research in Breast Cancer (2021)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Cancer Biology. ; Biomedical Research. ; Medical Biochemistry.
    Description / Table of Contents: Part I. Introduction -- Chapter 1. Translational Research in Surgical Oncology: Introduction and My Own Experience as a Surgeon-Scientist -- Part II. Breast Cancer Biology and Cell Signaling Pathways -- Chapter 2. Phospholipase Signaling in Breast Cancer -- Chapter 3. HER2 Signaling in Breast Cancer -- Chapter 4. Ras Signaling in Breast Cancer -- Chapter 5. Epigenetic Regulation in Breast Cancer -- Chapter 6. Role of tRNAs in Breast Cancer Regulation -- Chapter 7. Fusion Genes in Breast Cancer -- Chapter 8. DNA Damage Repair Inhibitor for Breast Cancer Treatment -- Part III. Cancer Stem Cell and Tumor Heterogeneity in Breast Cancer -- Chapter 9. Breast Cancer Metastasis -- Chapter 10. Single Cell Genomics for Tumor Heterogeneity -- Chapter 11. Advances in Tumor Sampling and Sequencing in Breast Cancer and their Application in Precision Diagnostics and Therapeutics -- Chapter 12. Cancer Stem Cell in Immune Microenvironment -- Chapter 13. Theranostics for Breast Cancer Stem Cells -- Chapter 14. Patient-Derived Xenograft Models in Breast Cancer Research -- Part IV Biomarkers for Precision Medicine in Breast Cancer Patients -- Chapter 15. Proteomic Interrogation in Cancer Biomarker -- Chapter 16. Next-Generation Sequencing-Based Biomarkers in Breast Cancer -- Chapter 17. Liquid Biopsy in Breast Cancer: Circulating Tumor Cells and Circulating Tumor DNA -- Chapter 18. Current Biomarkers for Precision Medicine in Breast Cancer -- Chapter 19. The Potential Predictors in Chemotherapy Sensitivity -- Chapter 20. Hormone Resistance -- Part V. Managing High Risk Women -- Chapter 21. High-Risk Population Based on BC Risk Factors -- Chapter 22. Breast Cancer-Related Low Penetrance Genes -- Chapter 23. Rare Coding Variants Associated with Breast Cancer -- Chapter 24. Multigene Panel Testing for Hereditary Cancer and Genetic Counseling -- Chapter 25. BRCA and Breast Cancer-Related High-Penetrance Genes -- Part VI. Next Generation Clinical Research -- Chapter 26. Clinical Databases for Breast Cancer Research -- Chapter 27. Care for Breast Cancer Survivors -- Chapter 28. Considerations in Oncoplastic Surgery -- Chapter 29. Diet Before and After Breast Cancer -- Chapter 30. Current Trends in and Indications for Endoscopy-Assisted Breast Surgery for Breast Cancer -- Chapter 31. Minimal Invasive and Individualizing Management of the Axillary Nodes -- Chapter 32. Malignant Phyllodes of Breast -- Chapter 33. Next-Generation Clinical Trials and Research with Successful Collaborations -- Part VII. Epilogue -- Chapter 34. Transformation of the Patient and Society: A Patient Survivors’ Group and Breast Cancer Awareness Campaign.
    Abstract: This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
    Type of Medium: Online Resource
    Pages: IX, 630 p. 122 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813296206
    Series Statement: Advances in Experimental Medicine and Biology, 1187
    URL: https://doi.org/10.1007/978-981-32-9620-6
    DOI: 10.1007/978-981-32-9620-6
    DDC: 571.978
    Language: English
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  • 50
    Online Resource
    Online Resource
    Ultra-Weak Photon Emission from Biological Systems : Endogenous Biophotonics and Intrinsic Bioluminescence (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Biotechnology. ; Medicine Research. ; Biology Research. ; Biomedical engineering. ; Biotechnology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Introduction -- Part 1. History of UPE research -- Mitogenetic rays -- Oxidation, free-radicals and ultraweak luminescence -- Biophotons and the International Institute of Biophysics (IIB) -- Part 2. Physics of light and light research -- Physics of photon emission -- Chemiluminescence as a tool for free radical research -- Highly sensitive imaging and spectral analysis of UPE from biological systems and their application -- Part 3. Molecular mechnisms of UPE -- Free radicals in biology -- Ultraweak luminescence from aqueous systems -- Chemiluminescence in oxidation of hydrocarbons: mechanistic fundamentals -- Chemiluminescence in oxidation of fatty acids and lipids -- Chemiluminescence in protein oxidation -- Emitters of endogenous biological chemiluminescence: quantum chemical modeling insights -- Enzymatic sources of free radicals -- Part 4. UPE research in life science -- Luminescence of animal tissues and vegetable oils -- Ultraweak photon emission from human body in relation to anatomy and histology -- Chronobiological aspects of spontaneous ultra-weak photon emission in humans: Ultradian, circadian and infradian rhythms -- Autoluminescence in seedlings: applications -- Application potentiality of Delayed Luminescence in Medicine, Biology and Food Quality researches -- Part 5. Mitogenetic effect and related phenomena: unresolved problems of UPE -- Mitogenetic effect: preface -- Mitogenetic effect in biological systems -- Physical properties of mitogenetic radiation -- Secondary, degradation and necrobiotic radiation -- Mitogenetic research in medicine: radiation of blood and cancer diagnostics -- Part 6. Non-chemical distant interaction hypothesis - pro et contra -- Non-chemical distant interaction: preface -- The possible functions of electromagnetic cell communication -- Understanding of Fritz-Albert Popp’s biophoton theory from the viewpoint of a biologist -- Limits to the information transfer through UPE -- Quantum nonlocality and biological coherence -- Part 7. Perspectives -- Integrating ultraweak photon emission in mitochondrial research -- Selected biophysical methods for enhancing biological autoluminescence -- Upconverting nanoparticles as sources of singlet oxygen -- Upconverting nanoparticles as sources of singlet oxygen -- Delayed Luminescence as a tool to study the structures of systems of biological interest and their collective long-living excited states -- Index.
    Abstract: This book addresses the phenomenon of biological autoluminescence (also known as ultraweak photon emission, UPE, biochemiluminescence, or biophotons) and deals with a very broad spectrum of subjects, ranging from basic observational studies to molecular mechanisms, free-radical processes, physics of electron excitation and photon emission, as well as detection techniques. The chapter topics include UPE in plants, animals, and the human body; microorganisms and subcellular structures; and model systems, illustrating its high prevalence. Several sections of the book provide some backstory, with emphasis on methodology, unresolved questions, and existing controversies. The authors raise and discuss complex, potentially divisive aspects: Are there any reasons to assume the existence of non-chemical interaction in biological systems? Can research results in the field of mitogenetic radiation, delayed luminescence, and oxychemiluminescence of model systems, be correctly interpreted? What does the future hold for this area of research? Altogether, this publication gives the reader a thorough overview of biological autoluminescence (UPE, biophotonics) research, making it ideal for students and researchers who are new to the area as well as those who are specializing in it.
    Type of Medium: Online Resource
    Pages: XII, 521 p. 345 illus., 198 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031390784
    URL: https://doi.org/10.1007/978-3-031-39078-4
    DOI: 10.1007/978-3-031-39078-4
    DDC: 660.6
    Language: English
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