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  • 1
    Keywords: Cancer. ; Molecular genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology. ; Cancer Biology. ; Molecular Genetics. ; Gastroenterology. ; Oncology. ; Nanotechnology.
    Description / Table of Contents: Chapter 1. Potential Role of Biomarkers, Biosensors, Technologies and Computational Methods in Early Detection of Gastrointestinal Cancer -- Chapter 2. Biomarkers as the Promising Tools for Early Detection of Gastrointestinal Cancer -- Chapter 3. Development and Evaluation of Biomarkers for Early Detection of Cancer -- Chapter 4. Prognostic Molecular Markers for Gastrointestitinal cancer -- Chapter 5. Metabolic Markers for Early Detection of Gastrointestinal Cancer -- Chapter 6. Current Status of MicroRNA-based Biomarkers for Gastric Cancer -- Chapter 7. Genetic Susceptibility Markers of Gastrointestinal Cancer -- Chapter 8. Approaches For Early Detection Of Gastrointestinal Cancer -- Chapter 9. Biosensors and its Applications for Early Detection of Gastrointestitinal Cancer -- Chapter 10. Application of Nanotechnology in Early Detection of Gastrointestinal Cancer -- Chapter 11. Genetic Marker Identification for the Detection of Early-Onset Gastrointestitinal Cancer Through Genome Wide Association Studies -- Chapter 12. Big Data Analytics to Discover Diagnostics and Therapeutics for Gastrointestitinal Cancer -- Chapter 13. System Biology Approach for Early Prognosis of Gastrointestinal Cancer.
    Abstract: This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.
    Type of Medium: Online Resource
    Pages: XXIII, 231 p. 38 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811544316
    Series Statement: Diagnostics and Therapeutic Advances in GI Malignancies,
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Biochemistry. ; Microbiology. ; Biotechnology. ; Biochemistry. ; Microbiology.
    Description / Table of Contents: Part I. Electron based Bioscience -- Chapter 1: (Tentative) Latest knowledges of (electro)microbiology -- Chapter 2: Importance of electron flow in (micro)biological metabolism -- Chapter 3: Extracellular electron transfer in bioelectrochemically active microorganisms -- Chapter 4: Direct interspecies electron transfer -- Chapter 5: Extracellular electron uptake mechanisms by sulfate reducing bacteria -- Chapter 6: Conversion of electric energy into life energy -- Part II. Electron based Biotechnology -- Chapter 7: Electrochemical interactions between microorganisms and conductive particles- Chapter 8: Bioelectrochemical reversible interconversion in the 2H+/H2 and CO2/formate redox systems and its importance in forthcoming energy system -- Chapter 9: Application of enzymatic reactions involving electron transfer for the production of useful chemicals -- Chapter 10: Fatty acid production of thraustochytrids and cellular redox balance -- Chapter 11: Control of microbial metabolisms by electrochemical cultivation method -- Part III. Electron based Biocorrosion -- Chapter 12: Microbiologically influenced corrosion -- Chapter 13: Electrochemistry on Corrosion Engineering -- Chapter 14: Microorganisms inducing microbiologically influenced corrosion -- Chapter 15: Electron flow rate in the corrosion and its application -- Chapter 16: Biocorrosion and souring in the crude oil production process -- Chapter 17: Metallurgical factors effect on bacterial adhesion and bio-corrosion.
    Abstract: This book offers a comprehensive introduction to electron-based bioscience, biotechnology, and biocorrosion. It both explains the importance of electron flow during metabolic processes in microorganisms and provides valuable insights into emerging applications in various fields. In the opening section, readers will find up-to-date information on topics such as electron transfer reactions, extracellular electron transfer mechanisms, direct interspecies electron transfer, and electron uptake by sulfate-reducing bacteria. The focus then shifts to state-of-the-art advances and applications in the field of biotechnology. Here, the coverage encompasses e.g. progress in understanding electrochemical interactions between microorganisms and conductive particles, enzymatic reactions and their application in the bioproduction of useful chemicals, and the importance of redox balance for fatty acid production. In closing, the book addresses various aspects of the complex phenomenon of microbiologically induced corrosion, highlighting novel insights from the fields of electromicrobiology and electrochemistry and their implications. .
    Type of Medium: Online Resource
    Pages: VIII, 229 p. 96 illus., 46 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811547638
    DDC: 660.6
    Language: English
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  • 3
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Geotechnical engineering. ; Refuse and refuse disposal. ; Mineralogy. ; Geotechnical Engineering and Applied Earth Sciences. ; Waste Management/Waste Technology. ; Mineralogy.
    Description / Table of Contents: Traditional Treatment of Mine Waste -- Solutions for Surface Disposal of Mine Tailings -- Case Study of Surface Consolidated Tailings Stockpile -- Case Study of Surface Cemented Tailings Discharge -- Solutions for Underground Placement of Mine Tailings -- Properties of Cemented Tailings Backfill -- Case Study of Cemented Tailings Backfill -- Solutions for Underground Placement of Coal Mine Waste -- Properties of Cemented Coal Gangue-Fly Ash Backfill -- Case Study of Cemented Coal Gangue-Fly Ash Backfill.
    Abstract: This book introduces recent development of technologies for mine waste management in China. For hard rock mines, the main mine wastes are tailings, and the tailings can be disposed above-ground and/or underground. The technology of consolidated tailings stockpile (CTS) that disposes tailings above-ground is introduced, and the application of this technology is also demonstrated. Besides, the technology of cemented tailings (or paste) backfill (CTB or CPB) which deals with tailings underground is also discussed. The properties of CTB materials and the utilization of CTB technology are described and analyzed. For coal mines, the main mine wastes are coal gangue and fly ash. The technology of cemented coal gangue-fly ash backfill (CGFB) that manages coal mine waste underground is presented. The THMC coupling properties of CGFB materials are investigated, which can contribute to a better design of stable, durable and environmentally friendly CGFB mixtures. The application of CGFB technology in a coal mine is also presented. This book, which systematically reviews and discusses the development of mine waste management technologies in China, is expected to provide readers comprehensive information about mine waste management.
    Type of Medium: Online Resource
    Pages: IX, 204 p. 174 illus., 151 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813292161
    DDC: 624.151
    Language: English
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  • 4
    Keywords: Geotechnical engineering. ; Geotechnical Engineering and Applied Earth Sciences.
    Description / Table of Contents: Chapter 1. Non-seismic and unconventional exploration methods for oil and gas in Cuba: perspective sectors -- Chapter 2. Geological-structural mapping and favorable sectors for oil and gas in Western Cuba through non-seismic exploration methods -- Chapter 3. Identification of hydrocarbon microseepage through remote sensors in the Majaguillar - Motembo sector, Cuba -- Chapter 4. Physical-geological modeling of potential fields in the northeastern zone of the Central Basin of Cuba.
    Abstract: The so-called "Non-conventional geophysical-geochemical exploration methods" are used, in the particular case of oil and gas exploration, for the detection and mapping of active microseepage of light hydrocarbons with a vertical nature on the gas-oil accumulations. The non-seismic exploration methods used in Cuba are: Remote Sensing, Gravimetry, Aeromagnetometry, Airborne Gamma Spectrometry (AGS) and Morphometry (non-conventional, from the Digital Elevation Model 90x90m). The AGS also classifies, as a non-conventional geophysical-geochemical method, together with the Redox Complex. Besides, it is of interest to know the geological-structural framework where these microseepage occur. That is why the benefits of using these methods (excluding Redox Complex), prior to their integration with geological and seismic data, translate into a first approximation, valid for an initial understanding of geology and mapping of favourable areas of possible gas-oil interest. Finally, from the implementation of these methods (including Redox Complex), perspective sectors for oil and gas are obtained, once the integration with geology and seismic has been carried out. The book presents a brief theoretical account of the methods used and, as practical results, a set of perspective sectors of possible interest for exploration in Cuba. As a complementary result, the book also offer an evaluation of the areas that meet the petroleum-geologist premises for the presence of large accumulations of high quality oil in Cuba.
    Type of Medium: Online Resource
    Pages: XXIX, 106 p. 63 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030929756
    Series Statement: SpringerBriefs in Earth System Sciences,
    DDC: 624.151
    Language: English
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  • 5
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Religion and sociology. ; Biotechnology. ; Biotechnology. ; Sociology of Religion.
    Description / Table of Contents: Preface -- Geography, Economy and Nationality of Shimenkan of Weining -- Methodist Churches in Zhaotong -- Shimenkan and Christianity -- Governance of the Miao nationality by the national government in Weining -- The Miao Nationality in Weining in Early People's Republic of China -- Social Reform of the Miao nationality in Weining -- Cooperative and People's Movement in Weining -- Socialist Education Movement" and "the Cultural Revolution" in Weining -- Reform and Opening up of Weining -- Shimenkan after Reform and Opening up -- Conclusion.
    Abstract: This book explores Shimenkan—a Miao-inhabited area in Weining County, China—and its rural society from a comprehensive and long-term perspective, drawing on research conducted by the author in the course of ten years. Located in the northwest of Weining County in Guizhou Province, Shimenkan is a multiethnic area, where, e.g., the Hans, Miaos, Yis, Huis, and Buyis live. Until the early twentieth century, it was a small mountain village; the introduction of Christianity led to significant cultural and social changes in this area. Focusing on China in the twentieth century, the book addresses the traditional culture of the Miao people, the popularity of Christianity in early modern times, the management and control by the government, the socialist reform in the period of the People’s Republic of China, and the changes following the reform and opening-up in recent years. Covering a century’s worth of history, it discusses the major historical events in Northeastern Yunnan and Northwestern Guizhou around Shimenkan and analyzes local social structures, religions, ideologies, customs, and ethnic psychologies, making it a valuable addition to the study of regional social history. The book draws on archives, literature reviews, and field surveys and pursues a multi-disciplinary approach combining history, anthropology, and other disciplines. It offers a valuable resource for researchers in history, religion, and ethnology, as well as readers interested in the spread of Christianity in the Miao-inhabited areas of southwestern China.
    Type of Medium: Online Resource
    Pages: XIV, 273 p. 45 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811989834
    DDC: 660.6
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Engineering geology. ; Environmental sciences. ; Physics. ; Geotechnical Engineering and Applied Earth Sciences. ; Geoengineering. ; Environmental Physics.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Engineering View of Soft Rocks -- Chapter 3. The Geology of Soft Rocks -- Chapter 4. Mudrocks as Soft Rocks -- Chapter 5. Sandstones in Dam Foundations and Tunnels -- Chapter 6. Geomechanical Characterization of Evaporitic Rocks -- Chapter 7. Site Investigation for Soft Rock Mass -- Chapter 8. Geomechanical Properties of Soft Rock Masses by Laboratory and In Situ Testing -- Chapter 9. Interaction Between Water and Soft Rocks -- Chapter 10. Weathering, Erosion, and Susceptibility to Weathering -- Chapter 11. Weathering Of Rocks In Brazil -- Chapter 12. Degradation Processes In Civil Engineering Slopes In Soft Rocks -- Chapter 13. Mining Slopes In Weathered And Weak Rocks -- Chapter 14. Correlation of Properties of Soft Rocks -- Chapter 15. Deformation mechanism of soft rock -- Chapter 16. Soft Rock Roadway Reinforcement -- Chapter 17.Large Deformation Support For Soft Rocks Engineering -- Chapter 18. Rock Mass Classification Of Chalk Marl In The Uk Channel Tunnels Using Q -- Chapter 19. Applications Of The Gsi System To The Classification Of Soft Rocks -- Chapter 20. Soft Rocks In Underground Hydroelectric Schemes -- Chapter 21. Tunneling In Weak Rock -- Chapter 22. Face Stability Of Tunnels In Soft Rocks -- Chapter 23. Characterization Of Soft Rocks In Brazilian Coal Beds -- Chapter 24. Soft Rocks In Dam Foundation And Dam Sites -- Chapter 25. Soft Rock As A Dam Construction Material. .
    Abstract: This book offers a practical reference guide to soft rock mechanics for engineers and scientists. Written by recognized experts, it will benefit professionals, contractors, academics, researchers and students working on rock engineering projects in the fields of civil engineering, mining and construction engineering. Soft Rock Mechanics and Engineering covers a specific subject of great relevance in Rock Mechanics – and one that is directly connected to the design of geotechnical structures under difficult ground conditions. The book addresses practical issues related to the geomechanical properties of these types of rock masses and their characterization, while also discussing advances regarding in situ investigation, safety, and monitoring of geotechnical structures in soft rocks. Lastly, it presents important case histories involving tunnelling, dam foundations, coal and open pit mines and landslides.
    Type of Medium: Online Resource
    Pages: X, 757 p. 521 illus., 371 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030294779
    DDC: 624.151
    Language: English
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  • 7
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Immunology. ; Medical microbiology. ; Molecular genetics. ; Stem cells. ; Cell death. ; Cancer Biology. ; Immunology. ; Medical Microbiology. ; Molecular Genetics. ; Stem Cell Biology. ; Cell Death.
    Description / Table of Contents: Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis -- Chapter 2. Autophagy – An agonist and antagonist with an interlink of apoptosis in cancer -- Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy -- Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment -- Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment -- Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment -- Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review -- Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis -- Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment -- Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic -- Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics -- Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications -- Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
    Abstract: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
    Type of Medium: Online Resource
    Pages: VII, 280 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811569302
    DDC: 571.978
    Language: English
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  • 8
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Enzymology. ; Proteins. ; Bioinformatics. ; Microbial genetics. ; Biotechnology. ; Enzymology. ; Proteins. ; Bioinformatics. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. Introduction to Glycoside Hydrolases: Classification, identification and Occurrence -- Chapter 2. Glycosyl Hydrolases – Biochemistry and Applications -- Chapter 3. Lignocellulolytic and Chitinolytic Glycoside Hydrolases: Structure, Catalytic -- Chapter 4. Role of glycosyl hydrolases in breakdown of lignocellulosic waste and its industrial applications -- Chapter 5. Marine glycosyl hydrolases as tool for industrial application -- Chapter 6. Glycosyl Hydrolases and Biofuel -- Chapter 7. Role of Glycoside hydrolases in pulp and paper industries -- Chapter 8. Application of glycosyl hydrolases in food industry -- Chapter 9. The effects of xylanase synergistic interactions during lignocellulose degradation and their significance for industry -- Chapter 10. Role of metagenomics in discovery of industrially important cellulase.
    Abstract: This book gathers selected studies on the industrial applications of glycoside hydrolases (GHs), presenting an updated classification of these enzymes, and discussing their structure, mechanisms, and various approaches to improve their catalytic efficiency. Further, it explains the various industrial applications of glycoside hydrolases in food, effluent treatment, biofuel production, and the paper and pulp industries. Lastly, the book provides a comparative analysis of glycosyide hydrolases and discusses the role of metagenomics in the discovery of industrially important enzymes. As such it is a thought-provoking, instructive and informative resource for biochemists, enzymologists, molecular biologists and bioprocess technologists. .
    Type of Medium: Online Resource
    Pages: XXI, 259 p. 35 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811547676
    DDC: 660.6
    Language: English
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  • 9
    Keywords: Biotechnology. ; Nanoscience. ; Nanochemistry. ; Materials. ; Biotechnology. ; Nanophysics. ; Nanochemistry. ; Materials Engineering.
    Description / Table of Contents: Chapter 1. Engineered Drug Delivery Systems: Insights of Biointerface -- Chapter 2. Tissue Engineering Strategies for Tooth and Dento-alveolar Region with Engineered Biomaterial and Stem Cells -- Chapter 3. Antifouling Peptoid Biointerfaces -- Chapter 4.Structure and Rheology of Hydrogels: Applications in Drug Delivery -- Chapter 5. Surface Engineering in Wearable Sensors for Medical Diagnostic Applications -- Chapter 6. Modulation of Physicochemical properties of Polymers for Effective Insulin Delivery Systems -- Chapter 7. Organization of Bio-molecules in Bulk and over the Nano-substrate: Perspective to the Molecular Dynamics Simulations -- Chapter 8. Medical Diagnostics Based on Electrochemical Biosensor -- Chapter 9. Nanomaterial functionalization Strategies in Bio-interface Development for Modern Diagnostic Devices -- Chapter 10. Bio-nano-Interface Engineering Strategies of AuNPs Passivation for Next-generation Biomedical Applications -- Chapter 11. Electrooptical Analysis as Sensing System for Detection and Diagnostic Bacterial Cells.
    Abstract: This book provides detailed information on the surface and surface chemistry of various biointerfaces for the understanding and development of biosensors, biocompatible devices, and drug delivery systems. It highlights the role of interfacial phenomena towards the behaviour of biomolecules on different surfaces and their significance in recent applications. The book also addresses various surface engineering techniques for the modification of biomaterials that are implemented for improving biocompatibility. It provides an updated scientific concept of various interactions of biological systems with surfaces/modified surfaces at the molecular and cellular level. The chapters include various in-vitro, in-vivo, ex-vivo models to illustrate various aspects of Biointerface Engineering. Finally, the book elucidates troubleshooting strategies and future prospects of Biointerface Engineering in Medical Diagnostics and Drug Delivery.
    Type of Medium: Online Resource
    Pages: VIII, 254 p. 78 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811547904
    DDC: 660.6
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cancer. ; Oncology. ; Cancer Biology. ; Oncology.
    Description / Table of Contents: Role of specific phytochemicals against gastrointestinal malignancies -- Role of phytochemicals on growth and metastasis of GI cancer -- Cancer Stem Cells as Therapeutic Targets for Gastrointestinal cancers -- Phytochemicals plus checkpoint inhibitors in GI cancers -- Crucial role of curcumin on gut microbiota associated with GI cancers -- Cellular and Molecular mechanisms of garlic compounds in common GI cancers -- Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy -- Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer -- Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors -- Therapeutic Efects Of Curcumin Against Colorectal Cancer -- Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes -- Role of Dietary Supplementation of Natural products in the Prevention and Treatment of Liver Diseases -- Emerging Roles of Phytochemicals in Hepatocellular Carcinoma -- Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma -- Index.
    Abstract: Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
    Type of Medium: Online Resource
    Pages: XI, 340 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484057
    DDC: 571.978
    Language: English
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