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  • Books  (91)
  • Cham :Springer International Publishing :  (91)
  • 571.96  (46)
  • 571.978  (45)
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  • Books  (91)
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  • 1
    Online Resource
    Online Resource
    Notch Signaling in Embryology and Cancer : Molecular Biology of Notch Signaling (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Challenge and Promise: A Snap-Shot on the Molecular Biology of Notch Signaling -- Overview of Basic Mechanisms of Notch Signaling in Development and Disease -- Ligand-induced cis-inhibition of Notch signaling: the role of an extracellular region of Serrate -- Phosphorylation and proteolytic cleavage of Notch in canonical and non-canonical Notch signaling -- Maheshvara a conserved RNA helicase regulates Notch signaling in Drosophila melanogaster -- Molecular Regulation of Notch Signaling by Gremlin -- Regulation of Notch Signaling in Drosophila melanogaster: the role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex -- Interaction of Long Non-Coding RNAs and Notch Signaling: Implications for Tissue Homeostasis Loss -- Insulin–dependent non-canonical activation of Notch in Drosophila: a story of Notch-induced muscle stem cells proliferation -- Molecular mechanisms of Notch signaling in lymphoid cell lineages development: NF-κB and beyond -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It summarizes the newest achievements on this topic from Notch’s flag-ship function in the development of the embryo and for various inherited diseases to the Notch signaling pathway’s role in the development of leukemia and in a number of cancers, including skin cancer, intestinal cancer and others. Additionally, the emerging new role of the Notch signaling pathway as a promising target for prevention and therapy of various diseases, including cancer, is discussed. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role for embryologic tissue patterning, for stem cells, in senescence, and on the regulation of Notch signaling by epigenetic and other factors including microRNAs, long non-codingRNAs, and more. Taken as a whole, with its companion books – Notch Signaling in Embryology and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XIII, 172 p. 32 illus., 31 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030364229
    Series Statement: Advances in Experimental Medicine and Biology, 1227
    URL: https://doi.org/10.1007/978-3-030-36422-9
    DOI: 10.1007/978-3-030-36422-9
    DDC: 571.978
    Language: English
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  • 2
    Online Resource
    Online Resource
    Tumor Microenvironment : Molecular Players – Part B (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: MicroRNAs in the tumor microenvironment -- The Impact of Estrogen in the Tumor Microenvironment -- The non-bone related role of RANK/RANKL signaling in cancer -- Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment -- Exosomes: Novel Players of Therapy Resistance in Neuroblastoma -- COX-2 Signaling in the Tumor Microenvironment -- Renin–angiotensin system in the tumor microenvironment -- Stem cell secreted factors in the tumor microenvironment -- Tight interplay between therapeutic monoclonal antibodies and the tumor microenvironment in cancer therapy -- Tumor Microenvironment & Nitric Oxide: Concepts and Mechanisms -- Index.
    Abstract: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including MicroRNAs, estrogen, Caveolin-1, Nitric Oxide, RANK/RANKL signaling, , COX-2 Signaling, Renin–angiotensin system, and more. Taken alongside its companion volumes, Tumor Microenvironment: Molecular Players – Part B updates us on what we know about the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 162 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030502249
    Series Statement: Advances in Experimental Medicine and Biology, 1277
    URL: https://doi.org/10.1007/978-3-030-50224-9
    DOI: 10.1007/978-3-030-50224-9
    DDC: 571.978
    Language: English
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  • 3
    Online Resource
    Online Resource
    Basic and Clinical Immunology by Names : From the Biblical Time Until the Present (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medicine History. ; Medicine Research. ; Biology Research. ; Immunology. ; History of Medicine. ; Biomedical Research.
    Description / Table of Contents: A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Z.
    Abstract: Hundreds of eponyms are used within the field of immunology—Petri dish, Crohn’s disease, Bence Jones protein, Kupffer cells, Freund's adjuvant, Ouchterlony immunodiffusion, to name just a few—but most of us don't know much about the individuals who gave their names to these terms. Where were they born and educated, what other accomplishments are they credited with, why has history chosen to remember them, or not? This book presents the first comprehensive collection of immunologic eponyms, and through them tells the story of this fascinating field, from its earliest beginnings to present day. Organized by surname and meticulously cross-referenced and indexed, this book offers historical anecdotes and little-known facts which scientists, clinicians, students, and general readers will find captivating and memorable. A one-of-a-kind introduction to immunology that serves as both a history lesson and current reference on the diseases, treatments, and individuals who have been crucial to this field.
    Type of Medium: Online Resource
    Pages: XXVIII, 405 p. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031145292
    URL: https://doi.org/10.1007/978-3-031-14529-2
    DOI: 10.1007/978-3-031-14529-2
    DDC: 571.96
    Language: English
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  • 4
    Online Resource
    Online Resource
    Tumor Microenvironment : Signaling Pathways – Part B (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Biophysics. ; Cell interaction. ; Cytology. ; Cancer Microenvironment. ; Mechanobiological Cell Signaling. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Neuregulin signaling in the tumor microenvironment -- HGF/c-Met signalling in the tumor microenvironment -- Eph/ephrin signaling in the tumor microenvironment -- Src signaling in cancer and tumor microenvironment -- Purinergic signaling within the tumor microenvironment -- TGFβ signalling in the tumor microenvironment -- Wnt Signaling in the Tumor Microenvironment -- Lysophospholipid Signalling and the Tumour Microenvironment -- Adenosine signaling in the tumor microenvironment -- Androgen signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 191 p. 31 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030471897
    Series Statement: Advances in Experimental Medicine and Biology, 1270
    URL: https://doi.org/10.1007/978-3-030-47189-7
    DOI: 10.1007/978-3-030-47189-7
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    The Systemic Effects of Advanced Cancer : A Textbook on Cancer-Associated Cachexia (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Immunology. ; Metastasis. ; Cytology. ; Cancer Biology. ; Oncology. ; Immunology. ; Metastasis. ; Cell Biology.
    Description / Table of Contents: Chapter 1. A Systemic View of Metastatic Disease: Inter-organ Crosstalk and Therapeutic Implications -- Part I. Systemic Regulation in Metastatic Disease -- Chapter 2. Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles -- Chapter 3. Bone Metastasis: Systemic Regulation and Impact on Host -- Chapter 4. Targeting Metastatic Disease: Challenges and New Opportunities -- Part II. Cachexia: A Debilitating Systemic Effect of Cancer -- Chapter 5. Signaling Pathways That Promote Muscle Catabolism in Cachexia -- Chapter 6. The Role of Interleukin-6 Cytokines in Cancer Cachexia -- Chapter 7. NF-kB Signaling in the Macroenvironment of Cancer Cachexia -- Part III. Therapy-induced Muscle Wasting -- Chapter 8. Therapy-induced Toxicities Associated with the Onset of Cachexia -- Chapter 9. Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy -- Part IV. Preventing and Targeting Cachexia in Cancer -- Chapter 10. New Developments in Targeting Cancer Cachexia -- Chapter 11. Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer.
    Abstract: This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
    Type of Medium: Online Resource
    Pages: VI, 203 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031095184
    URL: https://doi.org/10.1007/978-3-031-09518-4
    DOI: 10.1007/978-3-031-09518-4
    DDC: 571.978
    Language: English
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  • 6
    Online Resource
    Online Resource
    Amino Acids in Nutrition and Health : Amino acids in systems function and health (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical sciences. ; Cytology. ; Biochemistry. ; Nutrition   . ; Immunology. ; Health Sciences. ; Cell Biology. ; Biochemistry. ; Nutrition.
    Description / Table of Contents: Preface -- Amino acids in intestinal physiology and health -- Amino acid metabolism in the liver: nutritional and physiological significance -- Amino acids in circulatory function and health -- Epithelial dysfunction in lung diseases: effects of amino acids and potential mechanisms -- Amino acid metabolism in the kidneys: nutritional and physiological significance -- Amino acids in health and endocrine function -- Amino Acids in Reproductive Nutrition and Health -- Impacts of amino acids on the intestinal defensive system -- Maternal nutrient restriction and skeletal muscle development: Consequences for postnatal health -- Metabolism of amino acids in the brain and their roles in regulating food intake -- Metabolism and functions of amino acids in the skin -- Metabolism and functions of amino acids in sense organs. .
    Abstract: This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in all the systems of humans and other animals (including livestock, poultry, companion animals, and fish). It enables readers to understand the crucial roles of amino acids and their metabolites in the health and diseases of the circulatory, digestive, endocrine, immune, muscular, nervous, reproductive, respiratory, skeletal, and urinary systems, as well as the sense organs (eyes, ears, nose, skin, and tongue). Readers will learn that amino acids are not only the building blocks of protein, but are also signalling molecules, as well as regulators of gene expression, metabolic processes and developmental changes in the body. This knowledge will guide nutritional practices to improve the growth, development and health of humans and other animals, as well as prevent and treat chronic (e.g., obesity, diabetes, and cardiovascular disorders) and infectious (e.g., bacterial, fungal, parasite, and viral) diseases. Editor of this volume is an internationally recognized expert in nutritional biochemistry. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals as well as undergraduate and graduate students in animal science, biochemistry, biomedical engineering, biology, human medicine, food science, kinesiology, nursing, nutrition, pharmacology, physiology, toxicology, veterinary medicine, and other related disciplines. In addition, all chapters provide general and specific references to amino acids in systems health for researchers and practitioners in biomedicine, animal and plant agriculture, and aquaculture, and for government policy makers.
    Type of Medium: Online Resource
    Pages: VI, 220 p. 36 illus., 10 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030453282
    Series Statement: Advances in Experimental Medicine and Biology, 1265
    URL: https://doi.org/10.1007/978-3-030-45328-2
    DOI: 10.1007/978-3-030-45328-2
    DDC: 571.96
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cancer Biology: How Science Works (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Genetics. ; Molecular biology. ; Cancer Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: 1. Introduction to cancer -- 2. Oncogenes, signal transduction and the hallmarks of cancer -- 3. Tumor suppressor genes and cell fate control -- 4. Multi-step tumorigenesis and genome instability -- 5. Cancer genomics -- 6. Cancer epigenomics -- 7. Aging and cancer -- 8. Tumor microenvironment -- 9. Metastasis and cachexia -- 10. Cancer immunity -- 11. Architecture of cancer therapies.
    Abstract: Cancer is a collection of diseases that can affect basically every organ of our body, all of which have in common uncontrolled cellular growth. The cells forming our body have the potential to grow in the context of wound healing or for the constant replacement of cells in our blood, skin or intestine. Behind every newly diagnosed malignant tumor in adulthood there is an individual history of probably 20 or more years of tumorigenesis. Therefore, malignant tumor formation often takes time making cancer in most cases to an aging-related disease that we seem not to be able to evade. However, tumorigenesis is dependent on multiple environmental influences, many of which we have under control by lifestyle decisions, such as retaining from smoking, selecting healthy food and being physically active. Thus, cancer preventive interventions are the most effective way to fight against cancer. This textbook wants not only to describe basic mechanisms leading to cancer but also to provide the readers with a more holistic view including cancer surveaillance mechanisms of the immune system. We will place these insights in the context of the personal consequences of everyone’s lifestyle decisions. The content of the book is linked to the lecture course in “Cancer Biology”, which is given by Prof. Carlberg since 2005 at the University of Eastern Finland in Kuopio. Moreover, biological processes explained in this book will be set into a clinical context using the experience of Dr. Velleuer in the daily care in oncology. This book also relates to the textbooks “Mechanisms of Gene Regulation: How Science Works” (ISBN 978-3-030-52321-3), “Human Epigenetics: How Science Works” (ISBN 978-3-030-22907-8) and “Nutrigenomics: How Science Works” (ISBN 978-3-030-36948-4), the studying of which may be interesting to readers who like to get more detailed information.
    Type of Medium: Online Resource
    Pages: XVII, 167 p. 72 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030756994
    URL: https://doi.org/10.1007/978-3-030-75699-4
    DOI: 10.1007/978-3-030-75699-4
    DDC: 571.978
    Language: English
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  • 8
    Online Resource
    Online Resource
    Tumor Microenvironment : Extracellular Matrix Components – Part A (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: The tumor microenvironment: focus on extracellular matrix -- Keratan Sulphate in the Tumour Environment -- Hyaluronan in the tumor microenvironment -- Fibronectin in the tumor microenvironment -- Matrix metalloproteinases role in tumor microenvironment -- Flipping the Molecular Switch: Influence of Perlecan and its Modifiers in the Tumor Microenvironment -- Heparan sulfate in the tumor microenvironment -- The role of Glypican-1 in the tumour microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components with the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newer generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book will be an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.
    Type of Medium: Online Resource
    Pages: XI, 181 p. 29 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030401467
    Series Statement: Advances in Experimental Medicine and Biology, 1245
    URL: https://doi.org/10.1007/978-3-030-40146-7
    DOI: 10.1007/978-3-030-40146-7
    DDC: 571.978
    Language: English
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  • 9
    Online Resource
    Online Resource
    Current Advances in the Science of Osteosarcoma : Research Perspectives: Tumor Biology, Organ Microenvironment, Potential New Therapeutic Targets, and Canine Models (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medical microbiology. ; Cytology. ; Pediatrics. ; Cancer Biology. ; Medical Microbiology. ; Cell Biology. ; Pediatrics.
    Description / Table of Contents: The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies -- Genomics and the Immune Landscape of Osteosarcoma -- RECQ DNA Helicases and Osteosarcoma -- Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma -- Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma -- Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response -- Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma -- Wnt Signaling in Osteosarcoma -- Receptor Tyrosine Kinases in Osteosarcoma: 2019 update -- The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets -- Autophagy in OS -- Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs -- Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment -- Comparative Immunology and Immunotherapy of Canine Osteosarcoma -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
    Type of Medium: Online Resource
    Pages: XIII, 233 p. 34 illus., 23 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030430856
    Series Statement: Advances in Experimental Medicine and Biology, 1258
    URL: https://doi.org/10.1007/978-3-030-43085-6
    DOI: 10.1007/978-3-030-43085-6
    DDC: 571.978
    Language: English
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  • 10
    Online Resource
    Online Resource
    Advanced Concepts in Human Immunology: Prospects for Disease Control (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Pharmacology. ; Diseases. ; Cancer. ; Immunology. ; Pharmacology. ; Diseases. ; Cancer Biology.
    Description / Table of Contents: 1. Human Chronic Viruses: Pathogenesis, host response, and treatment -- 2. Defining the Role of Immunoproteomics in Human Immunotherapy -- 3. Microbiome and Cellular Players in Type 1 Diabetes: from Pathogenesis to Protection -- 4. Immune Mechanisms, Pathology, and Management of Allergic Ocular Diseases -- 5. Dendritic Cell-regulated T Cell Immunity and Tolerance against Acute Myeloid Leukemia -- 6. Perspectives on the Role of T cell Negative Immune Checkpoint Receptors in Health and Disease -- 7. Neuroprotective Immunity for Neurodegenerative and Neuroinfectious Diseases -- 8. Polycystic Ovary Syndrome: An overview of a complex, heterogeneous genetic condition.
    Abstract: This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.
    Type of Medium: Online Resource
    Pages: XVIII, 403 p. 16 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030339463
    URL: https://doi.org/10.1007/978-3-030-33946-3
    DOI: 10.1007/978-3-030-33946-3
    DDC: 571.96
    Language: English
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  • 11
    Online Resource
    Online Resource
    Outbreak in the Village : A Family Doctor's Lifetime Study of Whooping Cough (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Life sciences. ; Pharmacology. ; Medical sciences. ; Medicine History. ; Public health. ; Immunology. ; Life Sciences. ; Pharmacology. ; Health Sciences. ; History of Medicine. ; Public Health.
    Description / Table of Contents: 1. Introduction -- 2. From Africa to England -- 3. The children's clinic at Keyworth -- 4. Whooping cough vaccine -- 5. 1977-79: The first outbreak of whooping cough -- 6. Does the vaccine work? -- 7. 1981: Whooping cough vaccine is very rarely harmful -- 8. 1981-83: The second outbreak. How many cases are there really? -- 9.1985-87: The third outbreak. The search for subclinical infection -- 10. Does the effectiveness of the vaccine wear off? -- 11. 1988: Trying to raise the uptake of pertussis vaccine -- 12. 1989-91: The fourth outbreak. The natural history of whooping cough -- 13. 1990's: Whooping cough fades away but new diagnostic tests emerge -- 14. 2000: Whoopingcough.net. Overcoming diagnostic paralysis -- 15. The early noughties: The new tests aid the rediscovery of whooping cough -- 16. Late noughties: "Resurgence" of whooping cough in the USA and Australia puts the UK on alert -- 17. 2012: Whooping cough diagnoses peak in the UK but remain unchanged in Keyworth -- 18. What lies ahead? -- 19. Epilogue -- Appendix.
    Abstract: Outbreak in the Village is a fascinating account of the personal and professional journey of Dr. Doug Jenkinson, physician and researcher. Over the course of four decades in practice, Jenkinson traces the reemergence of whooping cough in the developed world, using his practice in the idyllic English countryside as a clinical control group. Keeping meticulous notes and indulging an itch to investigate, he explores one of history's most enigmatic and pervasive diseases. Jenkinson relates the tale of his life's work amid winsome anecdotes, relevant history, and practical advice. Told in an amiable, engaging voice with an expert balance of levity and earnestness, this story will charm casual readers interested in medical history and memoir, as well as doctors and researchers who identify with the experiences and may benefit from the research and techniques employed. Readers will find themselves in the examination room beside Jenkinson as the investigation unfolds, learning about the nature of the illness and the sweeping detrimental effects of an anti-vaccination campaign. An intriguing memoir about a mysterious illness, a public health failure, and one doctor's quest for clarity, Outbreak in the Village is a tale of perseverance and objectivity sure to delight and inform. .
    Type of Medium: Online Resource
    Pages: XXIII, 158 p. 63 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030454852
    Series Statement: Springer Biographies,
    URL: https://doi.org/10.1007/978-3-030-45485-2
    DOI: 10.1007/978-3-030-45485-2
    DDC: 571.96
    Language: English
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  • 12
    Online Resource
    Online Resource
    Heparanase : From Basic Research to Clinical Applications (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    URL: https://doi.org/10.1007/978-3-030-34521-1
    DOI: 10.1007/978-3-030-34521-1
    DDC: 571.978
    Language: English
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  • 13
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    Online Resource
    Molecular Immunology : How Science Works (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Autoimmunity. ; Inflammation. ; Immunogenetics. ; Tumors Immunological aspects. ; Immunology. ; Translational Immunology. ; Autoimmunity. ; Inflammation. ; Immunogenetics. ; Tumour Immunology.
    Description / Table of Contents: 1 Cells and tissues of the immune system -- 2 Innate immunity and inflammation -- 3 Adaptive immunity and antigen receptor diversity -- 4 B cell immunity: BCRs, antibodies and their effector functions -- 5 Antigen-presenting cells and the major histocompatibility complex -- 6 T cell immunity: TCRs and their effector functions -- 7 Immunity to bacterial pathogens and the microbiome -- 8 Immunity to viral pathogens and the virome -- 9 Tolerance and transplantation immunology -- 10 Immunological hypersensitivities: Allergy and autoimmunity -- 11 Cancer immunology.
    Abstract: This textbook aims to describe in a condensed form the essentials of molecular immunology behind bacterial infections, the microbiome, viral infections (such as influenza and COVID-19), organ transplantations, autoimmunity, allergy and tumor immunology. The book emphasizes the impact of immunology in maintaining our health and preventing disease. Our immune system protects us not only from severe consequences of infectious diseases and getting cancer, but is also able to harm us severely via sepsis, cytokine storms and anaphylactic shocks. Molecular understanding of immunology should allow the reader a more rational handling of common diseases, most of which are associated with chronic inflammation.
    Type of Medium: Online Resource
    Pages: XV, 219 p. 94 illus., 93 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040252
    URL: https://doi.org/10.1007/978-3-031-04025-2
    DOI: 10.1007/978-3-031-04025-2
    DDC: 571.96
    Language: English
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  • 14
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    Online Resource
    Nrf2 and its Modulation in Inflammation (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Cytology. ; Molecular genetics. ; Stress (Physiology). ; Immunology. ; Cell Biology. ; Molecular Genetics. ; Cellular Stress.
    Description / Table of Contents: Chapter 1. Molecular mechanisms of Nrf2 in inflammation: Interactions between Nrf2 and inflammatory mediators -- Chapter 2. Nrf2 in immune responses during inflammation -- Chapter 3. Nrf2 and Nrf2-interacting network in respiratory inflammation and diseases -- Chapter 4. Nrf2 in the regulation of endothelial cell homeostasis during inflammation -- Chapter 5. The roles of Nrf2 in cardiovascular system and atherosclerosis -- Chapter 6. Nrf2 and inflammation-triggered carcinogenesis -- Chapter 7. Role of Nrf2 in oxidative and inflammatory processes in obesity and metabolic diseases -- Chapter 8. Modulators of Nrf2 Activation during Inflammation.
    Abstract: Nrf2, a transcription factor that mediates transcriptional responses to oxidative and xenobiotic stresses, plays a central role in cellular protection against internal or external toxins. Defects in Nrf2 and the relevant regulatory pathways are associated with a number of pathologies including inflammation,respiratory diseases, cardiovascular dysfunctions, metabolic syndrome and diabetes, neurodegeneration, and cancer. This book comprehensively reviews the up-to-date discoveries for the roles of Nrf2 in several human diseases in the context of inflammation. In particular, the molecular mechanisms that mediate the functions of Nrf2 and its interacting network in inflammation and pathogenesis are explicated. In addition, the research and therapeutic applications of Nrf2-targeting compounds in different diseases were summarized. This book is expected to be a valuable reference for worldwide researchers conducting both mechanistic and therapeutic studies of Nrf2 and relevant factors.
    Type of Medium: Online Resource
    Pages: IX, 205 p. 51 illus., 12 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030445997
    Series Statement: Progress in Inflammation Research, 85
    URL: https://doi.org/10.1007/978-3-030-44599-7
    DOI: 10.1007/978-3-030-44599-7
    DDC: 571.96
    Language: English
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  • 15
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    Online Resource
    Sunlight, Vitamin D and Skin Cancer (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Dermatology. ; Oncology. ; Cancer Biology. ; Dermatology. ; Oncology.
    Description / Table of Contents: Section I: Introduction -- Lessons learned from paleolithic models and evolution for human health: a snap shot on beneficial effects and risks of solar radiation -- Section II: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences (I) -- Sunlight, UV-radiation, vitamin D and skin cancer: how much sunlight do we need? -- Section III: Solar radiation, Vitamin D and human health -- Vitamin D status and cancer incidence and mortality -- Vitamin D receptors polymorphisms and cancer -- On the relationship between sun exposure and all-cause mortality -- Lindqvist PG (2020) Women with greater sun exposure habits seem to be healthier and to live longer. Are these results in contrast to other research? No -- Section IV: Epidemiology of skin cancer -- Epidemiology of skin cancer and UV radiation – update 2019 -- Solar UV exposure and mortality from skin tumors: an update -- Solarium Use and Risk for Malignant Melanoma: many open questions,not the time to close the debate -- Section V: Photocarcinogenesis of skin cancer -- Molecular biology of basal and squamous cell carcinomas -- Human papillomaviruses and skin cancer -- The immune system and pathogenesis of melanoma and nonnmelanoma skin cancer -- Section VI: The relevance of the vitamin D endocrine system for skin cancer -- Protection from ultraviolet damage and photocarcinogenesis by vitamin D compounds -- The role of classical and novel forms of vitamin D in the pathogenesis and progression of non-melanoma skin cancers -- The Vitamin D Receptor as tumor suppressor in skin -- Cancer prevention in skin and other tissues via cross-talk between vitamin D- and p53- signalling -- Section VII: Prevention and Management of Skin Cancer -- Sunscreens in the United States: Current Status and Future Outlook -- A handful of sunscreen for whole body application -- Sunlight, vitamin D and Xeroderma pigmentosum -- Update: Solar UV-radiation, vitamin D and skin cancer surveillance in organ transplant recipients (OTRs) -- Section VIII: UV-induced cutaneous synthesis of vitamin D and the physiologic consequences – II. promise and outlook -- Ultraviolet exposure scenarios: balancing risks of erythema and cutaneous vitamin D synthesis -- The Paleolithic nutrition model in relation to ultraviolet light and vitamin D -- Index.
    Abstract: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‑exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
    Type of Medium: Online Resource
    Pages: XIV, 428 p. 83 illus., 28 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030462277
    Series Statement: Advances in Experimental Medicine and Biology, 1268
    URL: https://doi.org/10.1007/978-3-030-46227-7
    DOI: 10.1007/978-3-030-46227-7
    DDC: 571.978
    Language: English
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  • 16
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    Online Resource
    Primary and Secondary Immunodeficiency : A Case-Based Guide to Evaluation and Management (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Rheumatology. ; Diseases. ; Hematology. ; Oncology. ; Primary care (Medicine). ; Immunology. ; Rheumatology. ; Diseases. ; Hematology. ; Oncology. ; Primary Care Medicine.
    Description / Table of Contents: Chapter 1. Overview of Immunodeficiency -- Part I. B-Lymphocyte Immunodeficiency -- Chapter 2. Common Variable Immunodeficiency, Hypogammaglobulinemia, and Specific Antibody Deficiency -- Chapter 3. Agammaglobulinemia -- Chapter 4. Class Switch Defects -- Chapter 5. Transient Immunodeficiency of Infancy -- Chapter 6. Selective Isotype Immunodeficiency -- Chapter 7. Common Variable Immunodeficiency Disorders-like Disorders -- Part II. T-Cell Immunodeficiency -- Chapter 8. Severe Combined Immunodeficiency -- Chapter 9. Idiopathic CD4 Lymphopenia -- Chapter 10. Hyper IgE Syndrome -- Chapter 11. Genetic Syndromes with Associated Immunodeficiencies -- Part III. Immune Dysregulation Syndromes -- Chapter 12. Autoimmune Lymphoproliferative Syndrome -- Chapter 13. Auto-inflammatory Syndromes -- Chapter 14. Immune Dysregulation Leading to Autoimmunity -- Chapter 15. Dendritic Cells in Primary Immunodeficiency -- Part IV. Innate Immune Defects -- Chapter 16. Congenital Neutropenia and Migration Defects -- Chapter 17. Chronic Granulomatous Disease -- Chapter 18. Primary Immunodeficiencies of Complement -- Chapter 19. Natural Killer Cell Defects -- Chapter 20. Mucocutaneous Candidiasis -- Part V. Secondary Immunodeficiency -- Chapter 21. Immunodeficiency Secondary to Malignancies and Biologics -- Chapter 22. Immunodeficiency Secondary to Prematurity, Pregnancy, and Aging -- Chapter 23. Vaccinations in Primary and Secondary Immunodeficiencies Including Asplenia.
    Abstract: This book provides a broad clinical overview of primary and secondary immunodeficiencies nested in clinical cases that will help the reader understand the approach to evaluation, diagnosis, and management of these challenging cases. Chapters begin with a comprehensive overview of immunodeficiencies to ground the reader in practical knowledge of the field and these complex conditions. Chapters cover B lymphocyte immunodeficiency, T cell immunodeficiency, immune dysregulation syndromes, and innate immune defects. They discuss a range of treatment options including gene therapy or bone marrow transplant. The book continues with a discussion on secondary immunodeficiencies and their treatment. Each chapter was written by authors with expertise related to different immunodeficiency disorders and provide a succinct overview of pathomechanisms, diagnosis, and treatment of a specific condition. Primary and Secondary Immunodeficiency will be an excellent resource for practicing allergists, hematologists, clinical immunologists, fellows, residents, and other clinicians who work with immunodeficiency patients.
    Type of Medium: Online Resource
    Pages: XI, 417 p. 34 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571573
    URL: https://doi.org/10.1007/978-3-030-57157-3
    DOI: 10.1007/978-3-030-57157-3
    DDC: 571.96
    Language: English
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  • 17
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    Online Resource
    Lung Inflammation in Health and Disease, Volume II (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Human physiology. ; Medicine Research. ; Biology Research. ; Respiratory organs Diseases. ; Immunology. ; Human Physiology. ; Biomedical Research. ; Pneumology.
    Description / Table of Contents: 1. Can GPCRs be targeted to control inflammation in asthma? -- 2. Cellular and molecular processes in pulmonary hypertension -- 3. INFLAMMATORY PATHWAYS IN SARCOIDOSIS -- 4. Innate Immune Responses and Pulmonary Diseases -- 5. Interstitial Lung Disease associated with Connective Tissue Diseases -- 6. Molecular mechanisms of vascular damage during lung injury -- 7. Neurotrophin Regulation and Signaling in Airway Smooth Muscle -- 8. Novel Thoracic MRI approaches for the assessment of pulmonary physiology and inflammation -- 9. Overview on Interactive Role of Inflammation, Reactive Oxygen Species and Calcium signaling in Asthma, COPD and Pulmonary Hypertension -- 10. Protein S-palmitoylation and lung diseases -- 11. Redox role of ROS and inflammation in pulmonary diseases -- 12. Semaphorin3E/PlexinD1 axis in asthma: what we know so far -- 13. Serine protease inhibitors to treat lung inflammatory diseases -- 14. Sex and Gender Differences in Lung Disease -- 15. Sex hormones and lung inflammation -- 16. Synopsis of Clinical Acute Respiratory Distress Syndrome (ARDS).
    Abstract: Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.
    Type of Medium: Online Resource
    Pages: XVI, 384 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030687489
    Series Statement: Advances in Experimental Medicine and Biology, 1304
    URL: https://doi.org/10.1007/978-3-030-68748-9
    DOI: 10.1007/978-3-030-68748-9
    DDC: 571.96
    Language: English
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  • 18
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    Online Resource
    Circulating Tumor Cells : Advances in Liquid Biopsy Technologies (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Treatment. ; Tumor markers. ; Cancer Biology. ; Cancer Therapy. ; Tumour Biomarkers.
    Description / Table of Contents: Part 1. CTC Technologies -- Affinity -- Physical -- ctDNA -- miRNA -- Exosomes -- Part 2 -- Biology of CTC -- Dormancy -- Culture -- EMT -- ctDNA and Exosomes -- Cells in circulation with CTC -- Part 3 -- CTC Analysis -- IHC, FISH, and other molecular assays -- Functional characterization -- Advanced microscopy and AI -- Analysis of non-cellular circulating markers -- Part 4 -- Clinical Applications of the Liquid Biopsy -- Early detection and cancer screening -- Prognosis and therapeutic monitoring -- Applications in Clinical Trials -- Applications in Drug Development.
    Abstract: It is well recognized that blood could be the optimal site for evaluating cancer, allowing easy and repeated access for determining prognosis, establishing molecular targets, evaluating the efficacy of therapy, detecting the earliest signs of recurrence, and even detecting cancer at its earliest and most curable stages. The analysis of cancer through blood samples is now known as the liquid biopsy and has been a rich source of research and clinical application. There has been an explosion of interest and progress in liquid biopsy technologies since the first edition of this book. The second edition will expand its focus to now include not only circulating tumor cells (CTC), but also other emerging aspects of the liquid biopsy, including circulating tumor DNA and methylated DNA (ctDNA, ct meDNA), ctRNA, ct miRNA, circulating tumor proteins (and other) biomarkers and circulating tumor derived exosomes (ctExosomes).
    Type of Medium: Online Resource
    Pages: XXI, 668 p. 77 illus., 72 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031229039
    Series Statement: Current Cancer Research,
    URL: https://doi.org/10.1007/978-3-031-22903-9
    DOI: 10.1007/978-3-031-22903-9
    DDC: 571.978
    Language: English
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  • 19
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    Online Resource
    Neurocognitive Complications of HIV-Infection : Neuropathogenesis to Implications for Clinical Practice (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Neurosciences. ; Virology. ; Immunology. ; Neuroscience. ; Virology.
    Description / Table of Contents: I. Neuropathogenesis and Biomarkers -- New Potential Axes of HIV Neuropathogenesis with Relevance to Biomarkers and Treatment -- Neurocognitive Impairment and Associated Genetic Aspects in HIV Infection -- Inflammatory Mechanisms and Cascades Contributing to Neurocognitive Impairment in HIV/AIDS -- Neuroimaging Advances in Diagnosis and Differentiation of HIV, Comorbidities, and Aging in the cART Era -- II. Neurocognitive Impairments in Low-, Middle- and High-Income Countries – Incidence / Prevalence and Contexts -- Neurocognitive Complications of Pediatric HIV Infections -- Neurocognitive Complications of HIV Infection in Women: Insights from the WIHS Cohort -- Cultural Neuropsychology Considerations in the Diagnosis of HIV- Associated Neurocognitive Disorders -- Neurocognitive Complications of HIV Infection in Low-Income Countries -- Deep Phenotyping of HIV Neurocognitive Complications Among Individuals Residing in High-Income Countries -- Reliably Measuring Cognitive Change in the Era of Chronic HIV Infection and Chronic HIV-Associated Neurocognitive Disorders -- III. Comorbidities and Complications -- Geriatric Syndromes in People Living with HIV Associated with Ageing and Increasing Comorbidities: Implications for Neurocognitive Complications of HIV Infection -- Conceptualizing and Assessing Everyday Functioning in the Context of HIV-Associated Neurocognitive Disorders -- Neuropsychiatric Disorders, Emotional Disturbances, and Their Associations with HIV-Associated Neurocognitive Disorder -- Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders -- HIV-Associated Neurocognitive Disorder (HAND): Relative Risk Factors -- IV. Screening, Interventions and Clinical Management -- Screening for HIV-Associated Neurocognitive Disorders: Sensitivity and Specificity -- Behavioral and Physical Activity Interventions for HAND -- Targeting HIV-Related Neurocognitive Impairments with Cognitive Training Strategies: Insights from the Cognitive Aging Literature -- Clinical Treatment Options and Randomized Clinical Trials for Neurocognitive Complications of HIV Infection: Combination Antiretroviral Therapy, Central Nervous System Penetration Effectiveness, and Adjuvants.
    Abstract: This volume aims at presenting the latest international research and discoveries in the neurocognitive aspects and complications in HIV/AIDS, and how this understanding can shape and inform how we think about clinical practice and patient care in HIV/AIDS as well as lead to a better understanding of the underlying neuropathogenesis. The chapter, "Metabolic Syndrome and Cardiovascular Disease Impacts on the Pathophysiology and Phenotype of HIV-Associated Neurocognitive Disorders", of this book is available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: XVII, 545 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030807597
    Series Statement: Current Topics in Behavioral Neurosciences, 50
    URL: https://doi.org/10.1007/978-3-030-80759-7
    DOI: 10.1007/978-3-030-80759-7
    DDC: 571.96
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  • 20
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    Online Resource
    Antibody Glycosylation (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Pharmacology. ; Biochemical markers. ; Analytical chemistry. ; Biotechnology. ; Immunology. ; Pharmacology. ; Biomarkers. ; Bioanalytical Chemistry. ; Biotechnology.
    Description / Table of Contents: Microheterogeneity of antibody molecules -- Part I: Analytical Methods -- Lectin and LC based methods for immunoglobulin (G) glycosylation analysis -- Mass spectrometry-based methods for immunoglobulin G N-glycosylation analysis -- CE based methods for Ig(G) glycosylation analysis -- Automation of Ig glycosylation analysis -- Bioinformatics in immunoglobulin glycosylation analysis -- Part II: Biosynthesis & Regulation -- N-glycan biosynthesis: Basic principles and factors affecting its outcome -- Genetic regulation of immunoglobulin G glycosylation -- Epigenetics of immunoglobulin G glycosylation -- IgG changes in aging and other inflammatory conditions -- Estrogen-driven changes in immunoglobulin G Fc glycosylation -- Part III: Effector Functions & Diseases -- Sweet rules – linking glycosylation to antibody function -- Immunoglobulin G glycosylation in diseases -- Immunoglobulin A glycosylation and its role in diseases -- Part IV: Applications -- Importance and monitoring of therapeutic immunoglobulin G glycosylation -- Glycosylation of plant-produced immunoglobulins -- The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine -- Glycosylation of antigen-specific antibodies - Perspectives on immunoglobulin G glycosylation in vaccination and immunotherapy.
    Abstract: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XII, 591 p. 66 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030769123
    Series Statement: Experientia Supplementum, 112
    URL: https://doi.org/10.1007/978-3-030-76912-3
    DOI: 10.1007/978-3-030-76912-3
    DDC: 571.96
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  • 21
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    Online Resource
    Interaction of Immune and Cancer Cells (2022)
    Cham :Springer International Publishing :
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    Keywords: Tumors Immunological aspects. ; Cancer Treatment. ; Oncology. ; Tumour Immunology. ; Cancer Therapy. ; Oncology.
    Description / Table of Contents: Chapter 1: Cancer immunoediting - elimination, equilibrium and immune escape in solid tumors -- Chapter 2: Tumor – Stroma Interaction and Cancer. - Chapter 3: Tumor-infiltrating lymphocytes and their role in solid tumor progression -- Chapter 4: Tumor-associated macrophages – reasons to be cheerful, reasons to be fearful -- Chapter 5: Polymorphonuclear neutrophils and tumors: friend or foe? -- Chapter 6: Role of NK cells in tumor progression -- Chapter 7: The role of myeloid-derived suppressor cells in tumor growth and metastasis -- Chapter 8: Cancer stem cells – an ever hiding foe -- Chapter 9: Adoptive T-cell immunotherapy – Perfecting self-defenses -- Chapter 10: Monoclonal antibodies to CTLA-4 with focus on ipilimumab.
    Abstract: Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.
    Type of Medium: Online Resource
    Pages: XIV, 350 p. 22 illus., 20 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030913113
    Series Statement: Experientia Supplementum, 113
    URL: https://doi.org/10.1007/978-3-030-91311-3
    DOI: 10.1007/978-3-030-91311-3
    DDC: 571.96
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  • 22
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    Online Resource
    Inflammation and Epilepsy: New Vistas (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Neurology . ; Neurosciences. ; Diseases. ; Pharmacology. ; Immunology. ; Neurology. ; Neuroscience. ; Diseases. ; Pharmacology.
    Description / Table of Contents: Pro and Anti-Inflammatory Neurovascular Processes in Epilepsy: A Fragile and Dynamic Equilibrium -- Emerging Molecular Mechanisms of Neuroinflammation in Seizure Disorders -- Glial Mechanisms of Inflammation during Seizures -- Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction and Epilepsy -- Blood T cells and Cytokine Levels during Interictal-Ictal Transitions -- Autoantibodies, Encephalopathies and Epilepsy -- Tau Protein in Drug-Resistant Epilepsy and Cognitive Decline -- Ketogenic Diet, Inflammation and Epilepsy -- Role of Regulatory T cells in Epilepsy -- Inflammation at the Neurovascular Unit in Post-Traumatic Epilepsy.
    Abstract: This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.
    Type of Medium: Online Resource
    Pages: VIII, 237 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030674038
    Series Statement: Progress in Inflammation Research, 88
    URL: https://doi.org/10.1007/978-3-030-67403-8
    DOI: 10.1007/978-3-030-67403-8
    DDC: 571.96
    Language: English
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    Cancer Neuroscience (2023)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Cancer Treatment. ; Neurosciences. ; Immunotherapy. ; Cancer Biology. ; Cancer Therapy. ; Neuroscience. ; Cancer Microenvironment. ; Immunotherapy.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Neuronal influence on cancer initiation and growth -- Chapter 2.1 Paracrine signaling in CNS primary tumors and brain metastases -- Chapter 2.2 Paracrine signaling in PNS primary tumors -- Chapter 3. Neuronal influence on cancer invasion and metastasis including perineurial invasion -- Chapter 4. Neurotrophic activity of tumors -- Chapter 5. Cancer interactions with Schwann cells -- Chapter 6. Cancer-glial interactions -- Chapter 7. Neuron-cancer synaptic and other electrical signaling -- Chapter 8. Neuro-immune interactions system and immuno-oncology -- Chapter 9. Nervous system interactions with non-immune elements in the cancer microenvironment -- Chapter 10. Cancer-induced remodeling of the nervous system -- Chapter 11. Cancer and pain -- Chapter 12. Systemic interactions of cancer and the impact on the nervous system -- Chapter 13. Tools and model systems to study nerve-cancer interactions -- Chapter 14. Conclusions and Future Directions.
    Abstract: This volume is the first on the market to address and discuss the emerging field of cancer neuroscience. Edited by pioneers in the field with contributions from top researchers, the volume serves as a comprehensive overview of the role of nerves in tumorigenesis and cancer progression. Chapters will address how the innervation of tumors can serve as both prognostic and predictive biomarkers as well as actionable therapeutic targets. Authors will describe current research efforts, and future directions for study and translation to the clinic. It is becoming increasingly apparent that certain treatments will need to consider interactions between the nervous system and cancer, and the novel concepts presented in the book address related accumulating evidence regarding therapeutic strategies. This unique volume will be useful for cancer researchers, neuroscientists, cancer biologists, oncologists, and others looking to gain a greater understanding of this emerging field.
    Type of Medium: Online Resource
    Pages: XII, 202 p. 21 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031324291
    URL: https://doi.org/10.1007/978-3-031-32429-1
    DOI: 10.1007/978-3-031-32429-1
    DDC: 571.978
    Language: English
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  • 24
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    Online Resource
    Cancer Metastasis Through the Lymphovascular System (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Metastasis. ; Lymphatics. ; Cancer Biology. ; Metastasis. ; Lymphatic System.
    Description / Table of Contents: Section 1: Genetic and Molecular Pathways of Cancer Growth and Metastasis -- Chapter 1. Hallmarks of Cancer: Molecular Underpinnings -- Chapter 2. Unifying concept of genomic changes: The mutational landscape of cancers -- Chapter 3. Tumor Microenvironment: Coconspirator in Tumorigenesis -- Chapter 4. Hallmarks of Metastasis: Molecular Underpinnings -- Chapter 5. Hereditary Cancer Syndromes and Cancer Metastasis -- Section 2: Pathology of Cancer Growth and Metastasis -- Chapter 6. Pathologic Assessment of Lymph Node Metastasis -- Chapter 7. Pathologic Assessment of Systemic or Distant Metastasis -- Chapter 8. The Role of Angiotropic Extravascular Migratory Metastasis in Metastases -- Section 3: Dormant Cancer Cells and their Reactivation in the Host Cancer Microenvironment -- Chapter 9. Tumor Dormancy and Relapse Regulated by the Extracellular Matrix -- Chapter 10. Therapy-Induced Dormancy and Residual Disease -- Section 4: The Microenvironment of Site-Specific Metastasis - Isaac P. Witz -- Chapter 11. The Microenvironment of Site-Specific Metastasis -- Section 5: Circulating Cancer Cells and Liquid Biopsy -- Chapter 12. Circulating tumor cells and ctDNA in sarcomas -- Chapter 13. Liquid biopsy using cell-free tumor DNA for gastrointestinal cancers -- Chapter 14. Circulating tumor cells and ctDNA in prostate cancer.-Chapter 15. Circulating Tumor Cells in Lung Cancer -- Chapter 16. CTCs/ ctDNA and Brain Metastasis.-Chapter 17. Epigenetics and liquid biopsy in oncology: role in metastasis and clinical utility -- Chapter 18. Metabolic reprogramming of circulating tumor cells for metastasis -- Section 6: Lymphatic System and Cancer Metastasis -- Chapter 19. Lymphatic System Biology, Pathobiology, and Relation to Cancer Metastasis -- Chapter 20. Lymphatic Specification and Development, EMT-MET, and Cancer Spread -- Chapter 21. Lymphangiogenesis, Lymph Nodes, Cancer Lymphangiogenesis and Metastasis -- Chapter 22. Immune cell trafficking in the lymphatics, hyaluronan biology and tumour metastasis -- Chapter 23. Lymphvascular Genomics and Proteomics, Clinical Syndromes, and Cancer Metastasis -- Chapter 24. Imaging of the Lymphatic System with Relevance to Cancer and Cancer Metastasis -- Chapter 25. Lymphedema: general pathophysiology, prevention and management in invasive cancer -- Section 7: Radiological Imaging of Early Cancer and Cancer Metastases -- Chapter 26. Primary Tumor Staging and Detection of Common Sites of Distant Metastatic Disease -- Chapter 27. Imaging Modalities in the Detection and Diagnosis of Metastatic Disease -- Chapter 28. Imaging of Bone Metastases -- Chapter 29. Imaging of Lung and Soft Tissue Metastases -- Chapter 30. Image-Guided Biopsy and Intervention for Metastatic Disease -- Section 8: Sentinel Lymph Node Surgery for Solid Cancer. Chapter 31. Sentinel Lymph Node Biopsy for Primary Cutaneous Malignancy -- Chapter 32. Sentinel Lymph Node Biopsy in Breast Cancer -- Chapter 33. Sentinel node navigation surgery for upper gastrointestinal cancer -- Chapter 34. Sentinel Lymph Node Mapping in Non-Small Cell Lung, Colon, and Thyroid Carcinomas -- Section 9: Surgical Treatment of Primary and Metastatic Cancer -- Chapter 35. The efficacy and evolution of surgical management based on cancer biology -- Chapter 36. The role of surgery in managing primary and metastatic melanoma -- Chapter 37. The Role of Surgery in Managing Primary and Metastatic Breast Cancer -- Chapter 38. The role of surgery in managing primary and metastatic colorectal cancer -- Chapter 39. The Role of Surgery in Management of Gastric Cancer -- Chapter 40. The role of surgery in managing primary and metastatic hepatopancreaticobiliary cancers -- Section 10: Cancer Metastasis to the Lung -- Chapter 41. Metastatic disease of the lung -- Section 11: Cancer Metastasis to the Liver -- Chapter 42. Tumor Resection and Ablation as a Means of Controlling Hepatic Metastases -- Chapter 43. Regional Arterial Infusional Therapy as a Means of Controlling Hepatic Metastases -- Section 12: Cancer Metastasis to the Bone -- Chapter 44. Molecular Mechanisms of Metastasis to the Bone.-Chapter 45. Surgical Management of Metastatic Disease to the Upper Extremity -- Chapter 46. Surgical Management of Metastatic Disease to the Lower Extremity -- Chapter 47. Surgical management of metastatic disease to the pelvis -- Chapter 48. Surgical Management of Metastatic Disease to the Spine -- Chapter 49. Interventional radiology techniques for management of skeletal metastases -- Section 13: Cancer Metastasis to the Brain and the Nervous System -- Chapter 50. Brain Metastases: Overview and Molecular Mechanisms -- Chapter 51. Indications and Techniques for Surgical Intervention in Patients with Metastatic Brain Tumors -- Chapter 52. Brain Metastases: Current and Future pharmacological treatment -- Chapter 53. Radiotherapy for CNS Metastases -- Chapter 54. Leptomeningeal Carcinomatoses -- Section 14: Urologic Cancer and 1st Patterns of Metastasis -- Chapter 55. Urologic Cancer and 1st Patterns of Metastasis -- Section 15: Biology and Clinical Aspects of Sarcoma Progression -- Chapter 56. Soft Tissue Sarcoma -- Chapter 57. Bone Sarcoma -- Chapter 58. Liposarcoma Metastasis -- Chapter 59. Desmoid Tumors.-Chapter 60. Atypical patterns of metastases: How do Sarcoma’s metastasize? -- Chapter 61. Tumor Immune Microenvironment of Soft Tissue Sarcoma -- Section 16: The Role of Radiation in the Treatment of Primary and Metastatic Cancer -- Chapter 62. Basic Principles of Radiobiology and Cancer Metastasis Prevention -- Chapter 63. Technical Innovations in the Delivery of Radiation Therapy -- Chapter 64. Radiation Therapy in the Definitive Treatment of Cancer -- Chapter 65. Radiation Therapy for Extracranial Oligometastatic Disease -- Chapter 66. Spine Radiotherapy -- Section 17: Immunotherapy of Solid Malignancies -- Chapter 67. Immunotherapy in Melanoma and Merkel Cell Cancer -- Chapter 68. Landscape of Immunotherapy in Lung Cancer -- Chapter 69. Immuno-oncologic Treatment of Genitourinary Malignancies -- Section 18: Current Topics -- Chapter 70. Personalized Systemic Cancer Therapy -- Chapter 71. Cancer Stem Cells and Their Role in Metastasis -- Chapter 72. HPV Induced Cancers -- Chapter 73. Microbiome and Cancer Metastasis -- Chapter 74. Application of Artificial Intelligence in Research on Cancer and Its Metastasis.
    Abstract: This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions. .
    Type of Medium: Online Resource
    Pages: XXIV, 806 p. 145 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030930844
    URL: https://doi.org/10.1007/978-3-030-93084-4
    DOI: 10.1007/978-3-030-93084-4
    DDC: 571.978
    Language: English
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    Amino Acids in Nutrition and Health : Amino Acids in the Nutrition of Companion, Zoo and Farm Animals (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical sciences. ; Cytology. ; Biochemistry. ; Nutrition   . ; Immunology. ; Health Sciences. ; Cell Biology. ; Biochemistry. ; Nutrition.
    Description / Table of Contents: Prelims -- One-carbon metabolism and development of the conceptus during pregnancy: Lessons from studies with sheep and pigs -- Cell-specific expression of enzymes for serine biosynthesis and glutaminolysis in farm animals -- Amino acids in beef cattle nutrition and production (author to be identified) -- Amino acid nutrition and reproductive performance in ruminants -- Amino acids in the nutrition and production of sheep and goats -- Amino acids in swine nutrition and production -- Amino acid nutrition and metabolism in chickens -- Nutrition and functions of amino acids in fish -- Nutrition and functions of amino acids in aquatic crustaceans -- Amino acids in dog nutrition and health -- Amino acids in the nutrition, metabolism, and health of domestic cats -- Amino acid nutrition for optimum growth, development, reproduction, and health of zoo animals.
    Abstract: This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in companion (dogs and cats), zoo (carnivores, herbivores, and omnivores), and farm (including cattle, pigs, sheep, goats, chickens, fish, and crustaceans) animals. It enables readers to understand the crucial roles of amino acids and their metabolites in the growth, development, health, and metabolic diseases of these animals. Readers will learn from well-written chapters that amino acids are not only the building blocks of protein but are also signaling molecules and key regulators of gene expression and whole body homeostasis in companion, domestic, aquatic, and captive animals. The book also provides new and useful information on the optimum requirements of the animals for dietary amino acids. This knowledge will guide nutritional practices and daily management to improve the health and survival of all species and to enhance the productivity of livestock, poultry, and aquaculture enterprises worldwide to produce high-quality protein for human consumption. Editor of this volume is an internationally recognized expert in the biochemistry, nutrition and physiology of amino acids. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals and pet owners, as well as undergraduate and graduate students in animal science, aquaculture, zoology, wildlife, veterinary medicine, biology, biochemistry, food science, nutrition, pharmacology, physiology, toxicology, and other related disciplines. In addition, all chapters provide general and specific references to amino acid nutrition and metabolism for researchers and practitioners in animal agriculture, aquaculture, zoos, biomedicine, and plant science, and for government policy makers. Chapter 7 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VI, 256 p. 36 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030544621
    Series Statement: Advances in Experimental Medicine and Biology, 1285
    URL: https://doi.org/10.1007/978-3-030-54462-1
    DOI: 10.1007/978-3-030-54462-1
    DDC: 571.96
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    Amino Acids in Nutrition and Health : Amino Acids in Gene Expression, Metabolic Regulation, and Exercising Performance (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical sciences. ; Cytology. ; Biochemistry. ; Nutrition   . ; Immunology. ; Health Sciences. ; Cell Biology. ; Biochemistry. ; Nutrition.
    Description / Table of Contents: Chapter 1: Regulation of Gene Expression by Amino Acids in Animal Cells -- Chapter 2: Amino acids in cell signaling: regulation and function -- Chapter 3: Amino Acids in Endoplasmic Reticulum Stress and Redox Signaling -- Chapter 4: Amino Acids in Autophagy: Regulation and Function -- Chapter 5: Oxidation of Energy Substrates in Tissues of Fish: Metabolic Significance and Implications for Gene Expression and Carcinogenesis -- Chapter 6: Arginine, Agmatine and Polyamines: Key Regulators of Conceptus Development in Mammals -- Chapter 7: Interorgan Metabolism of Glutamate and Glutamine in Poultry -- Chapter 8: Interorgan Metabolism of Amino Acids in Health and Disease -- Chapter 9: Amino Acids and Their Metabolites for Improving Human Exercising Performance -- Chapter 10: Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans -- Chapter 11: Composition of Amino Acids in Foodstuffs for Humans and Animals -- Chapter 12: Dietary Intakes of Amino Acids and Other Nutrients by Adult Humans.
    Abstract: This book explains about amino acids (AAs) which are not only building blocks of protein, but are also signaling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular-weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds, and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products (e.g., ammonia, homocysteine, H2S, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are crucial for whole-body homeostasis and health. Adequate provision of one or a mixture of functional AAs or metabolites may be beneficial for ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility). Dietary supplementation of these nutrients can also optimize the efficiency of metabolic transformations to enhance muscle growth, milk production, and athletic performance, while preventing excess fat deposition and reducing adiposity. Therefore, functional AAs hold great promise in improving the growth, health, and well-being of individuals.
    Type of Medium: Online Resource
    Pages: VI, 227 p. 34 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030741808
    Series Statement: Advances in Experimental Medicine and Biology, 1332
    URL: https://doi.org/10.1007/978-3-030-74180-8
    DOI: 10.1007/978-3-030-74180-8
    DDC: 571.96
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    Tumor Microenvironment : State of the Science (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Biomechanics. ; Cancer Biology. ; Biomechanics.
    Description / Table of Contents: Metabolism in the tumor microenvironment -- Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment -- Viral hepatitis, inflammation, and tumour microenvironment -- Effects of HIV on the tumor microenvironment -- GLI2-mediated inflammation in the tumor microenvironment -- Stellate Cells in the Tumor Microenvironment -- Endothelial Progenitors in the Tumor microenvironment -- Chimeric antigen receptors for the tumour microenvironment -- Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A dragon-Like Weapon in a Non-Fantasy Game of Thrones -- Multiple dynamics in tumor microenvironment under radiotherapy -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more. Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 208 p. 28 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030445188
    Series Statement: Advances in Experimental Medicine and Biology, 1263
    URL: https://doi.org/10.1007/978-3-030-44518-8
    DOI: 10.1007/978-3-030-44518-8
    DDC: 571.978
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    Tumor Microenvironment : Recent Advances (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Novel techniques to study the bone-tumor microenvironment -- An emerging model for cancer development from a tumor -- microenvironment perspective in mice and humans -- Effects of Exercise on the Tumour Microenvironment -- Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment -- Multimodal molecular imaging of the tumour microenvironment -- Necrosis in the tumor microenvironment and its role in cancer recurrence -- The Multifaceted Effects of Autophagy on the Tumor Microenvironment -- The Sociobiology of Brain Tumors -- Tumor microenvironment conditioning by abortive lytic replication of oncogenic γ-herpesviruses -- The microbiome as a component of the tumor microenvironment -- Index.
    Abstract: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XI, 160 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030357276
    Series Statement: Advances in Experimental Medicine and Biology, 1225
    URL: https://doi.org/10.1007/978-3-030-35727-6
    DOI: 10.1007/978-3-030-35727-6
    DDC: 571.978
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    Tumor Microenvironment : Non-Hematopoietic Cells (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Adipocytes in the tumour microenvironment -- Fibroblasts in the tumor microenvironment -- Mesenchymal stem cells in the tumor microenvironment -- Hepatic stellate cells in liver tumor -- Pancreatic stellate cells: The key orchestrator of the pancreatic tumor microenvironment -- Endothelial cells in the tumor microenvironment -- Lymphatic endothelial cell progenitors in the tumor microenvironment -- Oligodendrocyte progenitors in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.
    Type of Medium: Online Resource
    Pages: X, 129 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030371845
    Series Statement: Advances in Experimental Medicine and Biology, 1234
    URL: https://doi.org/10.1007/978-3-030-37184-5
    DOI: 10.1007/978-3-030-37184-5
    DDC: 571.978
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    Diseases of the Breast during Pregnancy and Lactation (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Human physiology. ; Medicine Research. ; Biology Research. ; Gynecology . ; Cancer Biology. ; Human Physiology. ; Biomedical Research. ; Gynecology.
    Description / Table of Contents: Preface -- PART 1: Basic Considerations -- Anatomy and Physiology of the Breast during Pregnancy and Lactation -- Diagnosis of Breast Disorders in Pregnancy and Lactation -- Clinical Presentations of Breast Disorders in Pregnancy and Lactation -- PART 2: Benign and Premalignant Disorders of the Breast in Pregnancy and Lactation -- Benign Disorders of the Breast in Pregnancy and Lactation -- Mastitis, Breast Abscess, and Granulomatous -- Premalignant disorders of the Breast in Pregnancy and Lactation -- PART 3: Breast Cancer in Pregnancy and Lactation -- Epidemiology of Pregnancy-Associated Breast Cancer -- Histology of Pregnancy-Associated Breast Cancer -- Clinical presentation, Diagnosis, and Prognosis of Pregnancy-Associated Breast Cancer -- . Treatment of Pregnancy-Associated Breast Cancer -- Special Clinical Situations -- Prenatal Care during and after Breast Cancer Treatment -- Lactation during and after Breast Cancer -- Pregnancy in Breast Cancer Survivors. Impact of Breast Cancer Treatment on Fertility -- Fertility Counseling and Preservation for Breast Cancer Patients -- Pregnancy after Breast Reconstruction -- Pregnancy and Lactation: Risk or Protective Factors for Breast Cancer -- Psychological Aspects of Pregnancy and Lactation in Patients with Breast Cancer.
    Abstract: Symptoms of the breast in gravid women commonly represent physiological changes, however they may also be related to serious underlying breast disease; this challenging dilemma is aggravated by diagnostic and therapeutic limitations imposed by safety issues regarding the mother and fetus. A comprehensive coverage of all aspects of normal and pathologic breast changes during pregnancy and lactation, their diagnosis and management is provided in the present work. The organized structure of this book begins with gestational changes of the breast, while discussing safety, hazards, and arguments regarding diagnostic approaches. It then goes on by describing various clinical presentations and common and uncommon benign disorders during gravidity. The book then addresses pre-malignant lesions of the breast, opening the dialogue on how to manage these confusing lesions in pregnant and nursing women. It continues toward pregnancy-associated breast cancer, focusing on every facet of the problem, including epidemiology, diagnosis, treatment and complications, anesthetic considerations, prenatal care, and rare malignancies; and comes to an end by arguing main psychological concerns. In the midst of this orderly sequence fertility issues, pregnancy, and breastfeeding in women who have overcome their breast cancer are also discussed. This unique reference has been written by academic experts from different centers and diverse disciplines in a practical format. It is intended to be an ideal resource for every practitioner and specialist who manages complaints of gravid and nursing women or treats breast disorders in women of child bearing age.
    Type of Medium: Online Resource
    Pages: XXV, 216 p. 55 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030415969
    Series Statement: Advances in Experimental Medicine and Biology, 1252
    URL: https://doi.org/10.1007/978-3-030-41596-9
    DOI: 10.1007/978-3-030-41596-9
    DDC: 571.978
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    Systems Biology of MicroRNAs in Cancer (2022)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Tumor markers. ; Non-coding RNA. ; Cancers. ; Tumour Biomarkers. ; Non-coding RNAs.
    Description / Table of Contents: Chapter 1. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective -- Chapter 2. Circulating MicroRNAs as Cancer Biomarkers in Liquid Biopsies -- Chapter 3. Regulation of Immune Cells by MicroRNAs and MicroRNA-Based Cancer Immunotherapy -- Chapter 4. Machine-Learning-Based Methods and Best Practices of MicroRNA-Target Prediction and Validation -- Chapter 5. Turning Data to Knowledge: Online Tools, Databases and Resources in MicroRNA Research -- Chapter 6. Bioinformatics Methods for Modeling MicroRNA Regulatory Networks in Cancer -- Chapter 7. Analysis of the p53/MicroRNA Network in Cancer -- Chapter 8. Machine Learning Using Gene-Sets to Infer miRNA Function -- Chapter 9. miRNA:miRNA Interactions: A Novel Mode of miRNA Regulation and Its Effect on Disease -- Chapter 10. ClustMMRA v2: A Scalable Computational Pipeline for the Identification of MicroRNA Clusters Acting Cooperatively on Tumor Molecular Subgroups -- Chapter 11. 3D Modeling of Non-coding RNA Interactions.
    Abstract: This book provides an update on the latest development in the field of microRNAs in cancer research with an emphasis on translational research. Since the early 2000s, microRNAs have been recognized as important and ubiquitous regulators of gene expression. Soon it became evident that their deregulation can cause human diseases including cancer. This book focuses on the emerging opportunities for the application of microRNA research in clinical practice. In this context, computer models are presented that can help to identify novel biomarkers, e.g. in circulating microRNAs, and tools that can help to design microRNA-based therapeutic interventions. Other chapters evaluate the role of microRNAs in immunotherapy, immune responses and drug resistance. Covering key topics on microRNAs in cancer research this book is a valuable resource for both emerging and established microRNA researchers who want to explore the potential of microRNAs as therapeutic targets or co-adjuvants in cancer therapies.
    Type of Medium: Online Resource
    Pages: VII, 317 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031083563
    Series Statement: Advances in Experimental Medicine and Biology, 1385
    URL: https://doi.org/10.1007/978-3-031-08356-3
    DOI: 10.1007/978-3-031-08356-3
    DDC: 571.978
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    Tumor Microenvironment : Extracellular Matrix Components – Part B (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Stem cells. ; Regenerative medicine. ; Cytology. ; Cancer Microenvironment. ; Cancer Biology. ; Stem Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Cell Biology.
    Description / Table of Contents: Elastin in the Tumor Microenvironment -- Decorin in the tumor microenvironment -- Syndecan-1 in the tumor microenvironment -- Versican in the tumor microenvironment -- Chondroitin Sulphate Proteoglycans in the Tumour Microenvironment -- Lipoproteins and the Tumor Microenvironment -- The Role of BEHAB/Brevican in the Tumor Microenvironment: Mediating Glioma Cell Invasion and Motility -- Thrombospondin in Tumor Microenvironment -- Tenascin-C function in glioma: immunomodulation and beyond -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor microenvironment during cancer development. Furthermore, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include elastin, decorin, syndecan-1, versican, lipoproteins, brevican, thrombospondin, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part B updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapters authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.
    Type of Medium: Online Resource
    Pages: XIII, 178 p. 36 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484576
    Series Statement: Advances in Experimental Medicine and Biology, 1272
    URL: https://doi.org/10.1007/978-3-030-48457-6
    DOI: 10.1007/978-3-030-48457-6
    DDC: 571.978
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    Immunotherapy (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Immunology. ; Oncology. ; Cancer Biology. ; Immunology. ; Oncology.
    Description / Table of Contents: Overview of Basic Immunology and Clinical Application -- Advances in Diagnostic Procedures and their Applications in the era of Cancer Immunotherapy -- Immunotherapy for Melanoma -- Immunotherapy in Lung Cancer: From a minor God to the Olympus -- Immunotherapy in Gastrointestinal Malignancies -- Current Landscape of Immunotherapy in Genitourinary Malignancies -- Immuno-oncology for Gynecologic Malignancies -- Immunotherapy for Neuro-Oncology -- Immunotherapy and Radiation -- CAR T-cells -- Skin Reactions to Immune Checkpoint Inhibitors -- Gastrointestinal Tract Adverse Events -- Immune-Related Adverse Events: Pneumonitis -- Hepatobiliary Adverse Events -- Immune Checkpoint Inhibitors (ICIs) Related Cardiotoxicity -- Renal Toxicity -- Immune-Related Oral, Otologic and Ocular Adverse Events -- Cancer Imaging in Immunotherapy -- The Microbiome in Immuno-Oncology -- New developments in the use of Patient-reported outcomes in Cancer Patients undergoing Immunotherapies.
    Abstract: Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.
    Type of Medium: Online Resource
    Pages: XII, 339 p. 44 illus., 35 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030410087
    Series Statement: Advances in Experimental Medicine and Biology, 1244
    URL: https://doi.org/10.1007/978-3-030-41008-7
    DOI: 10.1007/978-3-030-41008-7
    DDC: 571.978
    Language: English
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    Circulating Tumor Cells in Breast Cancer Metastatic Disease (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Stem cells. ; Cancer Biology. ; Biomedical Research. ; Biotechnology. ; Stem Cell Biology.
    Description / Table of Contents: Preface -- Introduction – Biology of Breast Cancer Metastasis and Importance of the Analysis of CTCs -- Epithelial-Mesenchymal Plasticity in Circulating Tumor Cells, the Precursors of Metastasis -- Disseminated Tumor Cells and Dormancy in Breast Cancer Progression -- Methodology for the Isolation and Analysis of CTCs -- Advances in the Characterization of Circulating Tumor Cells in Metastatic Breast Cancer: Single Cell Analyses and Interactions, and Patient-derived Models for Drug Testing -- Circulating Tumor Cells (CTCs) Heterogeneity in Metastatic Breast Cancer: Different Approaches for Different Needs -- Relevance of CTC Clusters in Breast Cancer Metastasis -- Epigenetics of Circulating Tumor Cells in Breast Cancer -- Circulating Tumor Cells: Applications for Early Breast Cancer -- Clinical Relevance and Therapeutic Application of CTCs in Advanced Breast Cancer. .
    Abstract: This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.
    Type of Medium: Online Resource
    Pages: XV, 167 p. 15 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030358051
    Series Statement: Advances in Experimental Medicine and Biology, 1220
    URL: https://doi.org/10.1007/978-3-030-35805-1
    DOI: 10.1007/978-3-030-35805-1
    DDC: 571.978
    Language: English
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    Western Blotting for the Non-Expert (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Immunology. ; Biomedical Research. ; Biotechnology.
    Description / Table of Contents: Western blotting: How it began -- 2. Basics of Western Blotting -- 3.Basic Calculations in Western Blotting -- 4.Choosing The Right Antibody For Western Blotting -- 5. Sample Preparation -- 6. Blocking membranes at places that do not have transferred proteins -- 7. A Basic Method for Western Blotting -- 8. Trouble Shooting Western Blotting -- 9. Using Biotin to demonstrate western and dot blotting in University Practical Classes- A Guide To Instructors -- 10. Nitrocellulose Membrane Art -- 11. The Use Of A Harmless Invisible Ink To Send Secret Messages On Nitrocellulose Membranes And As A Substitute For The Harmful Radioactive Ink Used As A Marker In ECL Membrane Assays -- 12. Fingerprinting On Nitrocellulose And Polyvinylidene Difluoride Membrane -- 13. Spectrometric Determination Of Protein For Electrophoresis -- 14. Concentrating Proteins For Western Blotting -- 15. Dissolving Proteins Using Lysis Buffer -- 16. Blotting And Detecting Glycosaminoglycans -- 17. Passive Blotting From Tissue Slices -- 18. Localizing Proteins by Tissue Printing -- 19. Ultrasound Blotting -- 20. Obtaining Several Blots From A Single SDS-PAGE Gel By Passive Transfer -- 21. Diffusion Blotting From SDS-PAGE Gels Supported By Solid Plastic -- 22. Dot-Immunobinding -- 23. Simultaneous Immunoblotting Analysis With Activity Gel Electrophoresis -- 24. Protein Blotting By Centrifugation -- 25. Blotting And Immunostaining Of Multiple Antigenic Peptides -- 26. High Molecular Weight Protein Blotting Using Agarose Gel Electrophoresis -- 27. Cetyltrimethylammonium bromide PAGE And Eastern Blotting -- 28. Purification Of Autoantibodies Bound To An Autoantigen Immobilized On A Membrane Strip -- 29. Miniaturized Blotting -- 30. Affinity Immunoblotting -- 31. Transferring Coomassie Blue Stained Proteins from Polyacrylamide Gels To Transparencies -- 32. Protein Transfer From Immobilized pH Gradient Gels -- 33. SDS PAGE To Immunoblotting In Sixty Minutes -- 34. Western Blot Analysis Of Protein-DNA Complexes Formed DuringGel Shift Experiments -- 35. Electrophoretic Transfer Of High And Low Molecular Weight Proteins To Membranes Using Heat -- 36. Grid-immunoblotting -- 37. Far-western Blotting -- 38. Native Electrophoresis And Western Blot Analysis -- 39. Efficient Electroblotting Of Low Molecular Weight Protein After Staining With Coomassie -- 40. Avoiding Non-specific Binding Of Secondary Antibodies In Immunoblotting By Double-blotting -- 41.A Brief Introduction To Other Protein Blotting Methods -- 42. Quantitative Computerized Western Blotting In Detail -- 43. Common Problems In Electrophoresis.
    Abstract: This book fills the need for a simplified text covering western blotting protocols aimed not just at high school and college students, but the researcher with little to no experience in these techniques. It provides the principles, basic methodology, and tips and tricks to avoiding the common pitfalls of western blotting. The book also introduces simple protocols that can transform western blotting into a fun method, such as sending secret messages on membranes or using nitrocellulose membrane as a canvas for art. In addition to the techniques, this book also covers the history of western blotting, which originated from the development of the blotting of DNA. It then delves into the importance of protein blotting, brought to the fore by the fact that the procedure has been evolving constantly since its inception in 1979, and the fact that the scientific community is faced with a multitude of ways and means of transferring proteins to membranes.
    Type of Medium: Online Resource
    Pages: XXIII, 467 p. 611 illus., 170 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030706845
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    URL: https://doi.org/10.1007/978-3-030-70684-5
    DOI: 10.1007/978-3-030-70684-5
    DDC: 571.96
    Language: English
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    Anoikis : How the Extracellular Matrix Regulates Life-or-Death Decisions (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cell death. ; Cancer Biology. ; Cell Death.
    Description / Table of Contents: Preface -- Introduction -- The intersection of anoikis resistance and fatty acid metabolism in cancer -- Anoikis resistance in melanoma -- Anoikis mediated by stress-activated MAPK signaling pathways -- Metabolic Regulation of Anoikis -- Metabolic Reprogramming contributes to Anoikis resistance in Cancer Cells -- Role of the nuclear receptors in anoikis -- The roles of anoikis in cervical cancer -- Shc and the control of small GTPase dynamics in cellular anchorage -- Anoikis and the Human Gut Epithelium in Health and Disease -- Epithelial cell extrusion: the prelude to anoikis -- Microtubule modifications and mitochondria: role in anoikis.
    Abstract: This book provides a useful resource for graduate-level cancer cell biology courses. Since the first report, in 1994, of “anoikis”—the apoptosis that occurs when cells lack appropriate contact with the extracellular matrix—over 2,100 papers have been published on this subject. This book is the first comprehensive, in-depth and up-to-date compendium on anoikis. Chapters are authored by some of the leading researchers in the field. This book provides both mechanistic and translational information regarding anoikis, in a convenient format. Mechanistically, the following topics will be addressed in detail: The role of MAP kinase signaling The role of Shc proteins as cellular anchorage sensors The role of cellular metabolism, and fatty acid metabolism in particular, and how they are affected by oncogenic transformation How epithelial cell extrusion – the prelude to anoikis—is regulated in normal and cancer cells The convergence of TGF-b and androgen receptor signaling in the regulation of anoikis This book also discusses the specialized functions and dysregulation of anoikis in the following cancer settings: Colon cancer Melanoma Cervical cancer The book serves to update i nvestigators actively working on problems in the anoikis field, in either experimental or translational settings. For investigators encountering novel biological phenomena that might relate to anoikis, it serve as an entry point to the literature that does not require an extensive background in cell adhesion signaling or apoptosis mechanisms. .
    Type of Medium: Online Resource
    Pages: VIII, 202 p. 6 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030738563
    URL: https://doi.org/10.1007/978-3-030-73856-3
    DOI: 10.1007/978-3-030-73856-3
    DDC: 571.978
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    Molecular Biology of Human Cancers (2023)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Oncology. ; Cancer Biology. ; Biomedical Research. ; Oncology.
    Description / Table of Contents: Part I: Molecules, Genes, Cells and Mechanisms -- Chapter 1: An Introduction to Human Cancers -- Chapter 2: Cancer Genetics -- Chapter 3: DNA Damage and DNA Repair -- Chapter 4: Oncogenes -- Chapter 5: Tumor Suppressor Genes -- Chapter 6: Cancer Pathways -- Chapter 7: Cell Death and Replicative Senescence in Cancer -- Chapter 8: Cancer Epigenetics -- Chapter 9: Invasion and Metastasis -- Part II: Human Cancers -- Chapter 10: Leukemias And Lymphomas -- Chapter 11: Pediatric Cancers -- Chapter 12: Cancers of the Skin -- Chapter 13: Colorectal Cancer -- Chapter 14: Bladder Cancer -- Chapter 15: Lung Cancer -- Chapter 16: Renal Cell Carcinomas -- Chapter 17: Liver Cancer -- Chapter 18: Gastric Cancer -- Chapter 19: Breast Cancer -- Chapter 20: Prostate Cancer -- Part Iii: Prevention, Diagnostics and Therapy -- Chapter 21: Cancer Prevention -- Chapter 22: Cancer Diagnostics -- Chapter 23: Cancer Therapy.
    Abstract: This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
    Type of Medium: Online Resource
    Pages: XXI, 542 p. 229 illus., 221 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031162862
    URL: https://doi.org/10.1007/978-3-031-16286-2
    DOI: 10.1007/978-3-031-16286-2
    DDC: 571.978
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    Medical and Biomedical Updates (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Human physiology. ; Respiratory organs. ; Physiology. ; Immunology. ; Human Physiology. ; Respiratory Physiology.
    Description / Table of Contents: Role of IP3 Receptors in Shaping the Carotid Chemoreceptor Response to Hypoxia but not to Hypercapnia in the Rat Carotid Body: An Evidence Review -- The Role of Hyperbaric Oxygen Treatment for COVID-19: A Review -- Primary Immunodeficiencies - Diseases of Children and Adults: A Review -- Pneumococcal Vaccine in Adult Asthma Patients -- Immunoglobulin G Deficiency in Children with Recurrent Respiratory Infections with and without History of Allergy -- Pruritus Characteristics in Severe Atopic Dermatitis in Adult Patients -- Pathophysiological Responses to a Record-Breaking Multi-Hour Underwater Endurance Performance: A Case Study -- Respiratory Muscle Strength and Ventilatory Function Outcome: Differences between Trained Athletes and Healthy Untrained Persons -- Uroflowmetry and Altitude Hypoxia: A Report from Healthy Italian Trekkers and Nepali Porters during Himalayan Expedition -- Effects of Intraligamentary Injection of Osteogenic-Induced Gingival Fibroblasts on Cementum Thickness in the Dog Model of Tooth Root Resorption -- In-Silico Evaluation of Treatment of Periprosthetic Fractures in Elderly Patients after Hip Arthroplasty -- Appraisal of burden of caregivers to chronically rehabilitated patients with spinal cord injuries in a tertiary neurological center in Nepal.
    Abstract: This book integrates topics in basic research and clinical medicine as well as molecular and cell biology. It presents innovative advances in the field of immunodeficiency syndromes and viral/bacterial respiratory infections, including a novel hyperbaric oxygen treatment for COVID-19. A comprehensive insight is offered into the unresolved molecular pathways in chemosensing that plays a vital role in detecting insufficient tissue oxygenation, as well as in sporting accomplishments. Other articles address cardiorespiratory and humoral responses to hypoxia, the function of cementum in the repair and regeneration of teeth, and periprosthetic fractures following hip arthroplasty in the elderly. The issue of the overwhelming burdens on caregivers to spinal injury patients, damaging both health and psychosocial status, is addressed. The book promotes translation of scientific advances to the general medical practice. It will be a valuable reference for clinical healthcare professionals and researchers interested in innovative practices to improve the prevention, diagnosis, and management of diseases.
    Type of Medium: Online Resource
    Pages: VI, 131 p. 20 illus., 9 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030672164
    Series Statement: Clinical and Experimental Biomedicine, 1289
    URL: https://doi.org/10.1007/978-3-030-67216-4
    DOI: 10.1007/978-3-030-67216-4
    DDC: 571.96
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    Inflammation, Infection, and Microbiome in Cancers : Evidence, Mechanisms, and Implications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medical microbiology. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cancer Biology. ; Medical Microbiology. ; Biomedical Research. ; Human Physiology. ; Immunology.
    Description / Table of Contents: Chapter 1: The Microbiome And The Hallmarks Of Cancer -- Chapter 2: Microbiome In Human GI Cancers -- Chapter 3: The Gut Microbiome And Colorectal Cancer -- Chapter 4: Salmonella Infection In Human Cancers -- Chapter 5: Biomarkers Of Esophageal Cancers And Precancerous Lesions -- Chapter 6: Epithelial And Immune Cell Responses To Helicobacter Pylori That Shape The Gastric Tumor Microenvironment -- Chapter 7: Microbiome And Liver Cancer -- Chapter 8: THE MICROBIOME AND UROLOGIC CANCERS -- Chapter 9: Role Of Infections And Tissue Inflammation In The Pathology Of The Fallopian Tube And High-Grade Serous Ovarian Cancer -- Chapter 10: Commensal Microbes And Their Metabolites: Influence On Host Pathways In Health And Disease -- Chapter 11: Dietary And Microbiome In Cancer Prevention -- Chapter 12: Autophagy And Cancer-Current Biology And Drug Development -- Chapter 13: Mitochondrial Regulation Of Inflammation In Cancer -- Chapter 14: Modern Germ-Free Study Designs And Emerging Static Housing Technology In A Growing ‘Human Microbiome’ Market -- Chapter 15: Machine Learning In Identification Of Disease-Associated Microbiota -- Chapter 16: Mediation Analysis Of Microbiome Data And Detection Of Causality In Microbiome Studies.
    Abstract: This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.
    Type of Medium: Online Resource
    Pages: XII, 509 p. 31 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679514
    Series Statement: Physiology in Health and Disease,
    URL: https://doi.org/10.1007/978-3-030-67951-4
    DOI: 10.1007/978-3-030-67951-4
    DDC: 571.978
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    The Extracellular Matrix and the Tumor Microenvironment (2022)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Cytology. ; Clinical biochemistry. ; Cancer Biology. ; Cell Biology. ; Medical Biochemistry.
    Description / Table of Contents: Chapter 1: Small leucine-rich proteoglycans regulate cancer cell growth, apoptosis-and associated inflammation -- Chapter 2: The role of decorin in cancer -- Chapter 3: The mystery of syndecan-1 in tumor development and progression -- Chapter 4:Syndecan-2 Biology and its Role in Colorectal Carcinoma -- Chapter 5: Versican in Tumor Progression, Tumor-Host Interactions and Cancer Immunotherapy -- Chapter 6:Circulating proteoglycans/glycosaminoglycans as cancer biomarkers -- Chapter 7: Hyaluronan in the Extracellular Matrix of hematological and solid tumors. Its biological effects" -- Chapter 8: Heparanase: a paramount enzyme for cancer initiation, progression and metastasis -- Chapter 9: Laminins and matrix metalloproteinases connection: a subtle relationship that can go wrong in a tumor context, particularly if CD44 gets involved -- Chapter 10:Basement membrane, collagen, and fibronectin: physical interactions with cancer cells -- Chapter 11: Integrins in cancer: re-focusing on the tumor microenvironment -- Chapter 12: Adipose compounds in breast tumor extracellular matrix -- Chapter 13: Extracellular matrix as a metabolic niche in cancer -- Chapter 14: The role of inflammatory cells in tumor angiogenesis -- Chapter 15: Cancer angiogenesis and its master regulator perlecan -- Chapter 16: The microRNA-extracellular matrix interplay in breast cancer -- Chapter 17: The impact of the extracellular matrix on immunotherapy success -- Chapter 18: Exploiting hyaluronan-CD44 network in tumor therapy.
    Abstract: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: X, 494 p. 40 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030997083
    Series Statement: Biology of Extracellular Matrix, 11
    URL: https://doi.org/10.1007/978-3-030-99708-3
    DOI: 10.1007/978-3-030-99708-3
    DDC: 571.978
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    Mathematical, Computational and Experimental T Cell Immunology (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Bioinformatics. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Cytokine receptor signaling and CD4/CD8 lineage choice during T cell development in the thymus -- An agent-based model of T helper cell fate decisions in the thymus -- Modelling naive T cell homeostasis -- Mechanistic models of CD4 T cell homeostasis and reconstitution in health and disease -- Section 1MODELING THE DYNAMICS OF CD4+ T CELLS IN HIV- 1 INFECTION -- Modelling the response to Interleukin-7 therapy in HIV-infected patients -- Modeling immunopathology during persistent viral infections -- Delay in differentiation may suggest division of labour in models for CD8+ T cell differentiation -- Inferring differentiation order in adaptive immune responses from population level data -- Experimental and mathematical approaches to quantify recirculation kinetics of lymphocytes -- The public face and private lives of T cell receptor repertoires -- Population dynamics of immune repertoires -- Mathematical Modelling of T cell activation -- Agent-based model of heterogeneous T cell activation in vitro -- CTLA-4 mediated ligand trans-endocytosis: a stochastic model -- Automated gating and dimension reduction of high-dimensional cytometry data -- Index.
    Abstract: The purpose of this book is to present current mathematical and computational models that are used to describe and characterise the immunology of T cells. The reader will be exposed to a variety of tools/methods that go hand-in-hand with the T cell-mediated immunological process that is being modelled. We aim in the proposed book to emphasise the role that mathematical (or computational) modelling has already played in Immunology. Each chapter will provide an example of the contribution of mathematics to T cell immunology under one of the following four headings: i) Generation of hypotheses, ii) Quantification of immunological processes, iii) Definition of observables to measure given an experimental objective, iv) reconciling disparate (or even conflicting) experimental results. .
    Type of Medium: Online Resource
    Pages: X, 298 p. 74 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030572044
    URL: https://doi.org/10.1007/978-3-030-57204-4
    DOI: 10.1007/978-3-030-57204-4
    DDC: 571.96
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    Hormonal Pathology of the Uterus (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Endocrinology. ; Pathology. ; Cancer Biology. ; Endocrinology. ; Pathology.
    Description / Table of Contents: 1. Biophysiology of the uterus: development, cyclic changes, menopause -- 2. Hormonal effects in reproductive technology (ovulation stimulation, in vitro fertilization) -- 3. Hormonal role and therapy in common benign uterine lesions: endometrial polyps, leiomyomas, adenomyosis -- 4. Endometrial hyperplasia; precancerous lesions of the endometrium. Hormone therapy -- 5. Endometrial Carcinoma. Endometriosis, Hormonal Role in Carcinogenesis. Hormonal Therapy -- 6. Menopausal Hormone Therapy. Contraceptives -- 7. Replacement hormone therapy for gender dysphoria and congenital sexual anomalies -- 8. Hormone therapy for endometrial neoplasia related to breast cancer therapy (Tamoxifen) -- 9. Endometrial histopatholigic changes in hormonal therapy (contraceptives, ovulation stimulation, hormone replacement therapy, hormonal antitumoral therapy).
    Abstract: Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of “natural” hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women’s health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women’s health. .
    Type of Medium: Online Resource
    Pages: VIII, 185 p. 66 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030384746
    Series Statement: Advances in Experimental Medicine and Biology, 1242
    URL: https://doi.org/10.1007/978-3-030-38474-6
    DOI: 10.1007/978-3-030-38474-6
    DDC: 571.978
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    Lung Inflammation in Health and Disease, Volume I (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Human physiology. ; Medicine Research. ; Biology Research. ; Respiratory organs Diseases. ; Immunology. ; Human Physiology. ; Biomedical Research. ; Pneumology.
    Description / Table of Contents: 1. Potential role of mast cells in regulating corticosteroid insensitivity in severe asthma -- 2. Galectin-3 Promotes ROS, Inflammation and Vascular Fibrosis in Pulmonary Arterial Hypertension -- 3. Anti-Inflammatory Effects of Statins in Lung Vascular Pathology: From Basic Science to Clinical Trials -- 4. Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension -- 5. Pulmonary Inflammation and KRAS Mutation in Lung Cancer -- 6. microRNA Targets for Asthma Therapy -- 7. Roles of genetic predisposition in the sex-bias of pulmonary pathophysiology, as a function of estrogens -- 8. Hypercapnic respiratory failure-driven skeletal muscle dysfunction: It is time for animal mod-els-based mechanistic research -- 9. Role of airway smooth muscle in inflammation related to asthma and COPD -- 10. Systemic Sclerosis and Pulmonary Disease -- 11. Innate Lymphoid Cells in airway inflammation -- 12. Sjogren’s Syndrome and pulmonary disease -- 13. Redox Regulation, Oxidative Stress and Inflammation in Group 3 Pulmonary Hypertension -- 14. Sex-Steroid Signaling in Lung Diseases and Inflammation -- 15. Cytokines, Chemokines and Inflammation in Pulmonary Arterial Hypertension -- 16. Interactive roles of CaMKII/Ryanodine Receptor Signaling and Inflammation in Lung Diseases -- 17. Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis -- 18. Crosstalk between Lung and Extrapulmonary Organs in Infection and Inflammation -- 19. Inflammation in Pulmonary Arterial Hypertension -- 20. Lysophospholids in Lung Inflammatory Diseases.
    Abstract: Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung diseases are neither always effective, nor often condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases are not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung diseases, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, fellows, and students with new perspectives and concepts. The editor hopes this book will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.
    Type of Medium: Online Resource
    Pages: XV, 409 p. 54 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030630461
    Series Statement: Advances in Experimental Medicine and Biology, 1303
    URL: https://doi.org/10.1007/978-3-030-63046-1
    DOI: 10.1007/978-3-030-63046-1
    DDC: 571.96
    Language: English
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    Essential Aspects of Immunometabolism in Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Human physiology. ; Pathology. ; Immunology. ; Human Physiology. ; Pathology.
    Description / Table of Contents: Overview of Immune response -- Metabolic Pathway: from biochemistry to bench -- Mitochondrial biogenesis and dynamics in healthy and diseases -- Epigenetic regulation of metabolic pathways -- Metabolic pathways and cells signaling -- Metabolic profile of innate and adaptive immune cells -- Metabolic sensors and immunopathology -- Obesity, metabolic syndrome and inflammation.
    Abstract: Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases. The edited volume Essentials aspects of Immunometabolism will give the readers a broad view on how metabolic pathways can influence many types of immune cells during activation, differentiation and function, in health and disease. Of note, the structure of the book was created thinking not only on the experienced immunologist but also on undergraduate and graduate students, physicians, and all members of the scientific community interested in this exciting field of research.
    Type of Medium: Online Resource
    Pages: XII, 278 p. 38 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030866846
    URL: https://doi.org/10.1007/978-3-030-86684-6
    DOI: 10.1007/978-3-030-86684-6
    DDC: 571.96
    Language: English
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    Pathogenesis of Systemic Lupus Erythematosus : Insights from Translational Research (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medicine Research. ; Biology Research. ; Cytokines. ; Immunology. ; Biomedical Research. ; Cytokines and Growth Factors.
    Description / Table of Contents: Advances in translational science to identify new therapies for systemic lupus erythematosus -- Hallmark of systemic lupus erythematosus: Role of B Cell Hyperactivity. Fabien B Vincent, William A Figgett and Margaret L Hibbs -- B cell targeted therapies in systemic lupus erythematosus -- Type I Interferons and the perpetuation of a loss of tolerance -- Therapeutic Modulation of the Interferon Pathway in Systemic Lupus Erythematosus -- The concept of co-stimulatory blockade in SLE -- Cytokines: their role in amplifying SLE pathogenesis -- Intracellular targets in SLE -- Regulatory T cells in SLE -- Balancing strategies: GC and GILZ Axis.
    Abstract: The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
    Type of Medium: Online Resource
    Pages: XXI, 178 p. 36 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851613
    URL: https://doi.org/10.1007/978-3-030-85161-3
    DOI: 10.1007/978-3-030-85161-3
    DDC: 571.96
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    Emerging Modalities in Mitigation of Antimicrobial Resistance (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Immune response. ; Pathogenic microorganisms. ; Natural immunity. ; Biotechnology. ; Immunology. ; Antimicrobial Responses. ; Innate Immunity. ; Biotechnology.
    Description / Table of Contents: 1. Antimicrobials in livestock production and its cross-domain dynamics -- 2. Antibiotics and resistance in environment -- 3. Antimicrobials in agriculture and its implications in antimicrobial resistance -- 4. Modern diagnostic tools for rapid detection of multidrug resistance -- 5. The use of antimicrobials in agriculture and socio-economic considerations in a global world -- 6. Epidemiology of microbial infections -- 7. Socioeconomic impact of antimicrobial resistance and their integrated mitigation by One Health approach -- 8. Regulations in antimicrobial drug development: Challenges, and new incentives -- 9. New insights into and updates on antimicrobial agents -- 10. Polyphenols as emerging antimicrobial agents -- 11. Antimicrobial peptides and small molecules as antibiotics substitute -- 12. Molecular mechanisms of antimicrobial resistance in S. aureus biofilms -- 13. Antimicrobial resistance: Meaning and developing realization -- 14. Chemical diversity in fungi: strategies to mitigate antimicrobial resistance -- 15. Phage therapy as an alternative treatment in the fight against AMR: Real-world problems and possible futures -- 16. Omics and in-silico approaches in the surveillance and monitoring of antimicrobial resistance -- 17. Antimicrobial activity of bioactive compounds (Thymoquinone & Eugenol) and its nanoformulations therapeutic potential -- 18. Nanoparticles as a future alternative against multiple drug resistance -- 19. Nano-cargos boarded defensins to combat multi-drug resistance -- 20. Implementation of nano-vehicles to disguise and fight multi-drug resistance -- 21. Silver nanoparticles as potent multi-drug resistant in-corporants in biomedicine -- 22. Role of gold nanoparticles against bacterial multidrug resistance (MDR): An emerging therapeutic revolution -- 23. Carbon nanoparticles: A potential cost-effective approach to counter antimicrobial resistance -- 24. Antimicrobial interfaces as augmentative strategy against antimicrobial resistance -- 25. Nano-Strategies against rising antimicrobial resistance (AMR): Metallic nanoparticles as nano-weapon. .
    Abstract: This book provides an overview of cutting-edge and next-generation research and technologies for combating antimicrobial resistance. Antibiotic-resistant infections are projected to cause 10 million deaths annually by the year 2050. A sustainable, unified approach by researchers, practitioners, policymakers, and the public is urgently needed to stem this trend. This book aims to provide a comprehensive summary of current and future-facing efforts to mitigate the threat of AMR through a One-Health approach. This book is a valuable resource for students, researchers, policymakers, and the public about AMR and novel strategies to combat AMR.
    Type of Medium: Online Resource
    Pages: XII, 577 p. 62 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030841263
    URL: https://doi.org/10.1007/978-3-030-84126-3
    DOI: 10.1007/978-3-030-84126-3
    DDC: 571.96
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    Chikungunya Virus (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Pharmacology. ; Virology. ; Immunology. ; Pharmacology. ; Virology.
    Description / Table of Contents: Preface -- Molecular Virology of Chikungunya Virus -- Understanding molecular pathogenesis with chikungunya virus research tools -- Chronic Chikungunya Virus Disease -- Chikungunya Virus Vaccines: Platforms, Progress, and Challenges -- Small Molecule Inhibitors Targeting Chikungunya Virus.
    Abstract: This book provides readers with a collection of latest reviews written by Chikungunya virus (CHIKV) research leaders who cover topics related to CHIKV replication, advances in CHIKV research reagents and model system development, as well as the pathogenesis of chronic CHIKV disease. Moreover, the volume updates on recent progress in the development of therapeutics and vaccines for treatment and prevention of CHIKV-induced disease. Chikungunya virus (CHIKV) is a mosquito-borne pathogen that has re-emerged to become a significant global disease threat. Although CHIKV has historically been associated with localized outbreaks of debilitating polyarthralgia in Africa and Asia, factors such as increased global travel and viral adaptation to new mosquito vectors have led to the introduction and spread of CHIKV in new regions of the world, including the Americas. The re-emergence of CHIKV has stimulated significant interest both in understanding the biology of CHIKV and in the development of medical countermeasures against the virus.
    Type of Medium: Online Resource
    Pages: XI, 139 p. 10 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030906108
    Series Statement: Current Topics in Microbiology and Immunology, 435
    URL: https://doi.org/10.1007/978-3-030-90610-8
    DOI: 10.1007/978-3-030-90610-8
    DDC: 571.96
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    Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Inflammation. ; Autoimmunity. ; Allergy. ; Immunology. ; Inflammation. ; Autoimmunity. ; Allergology.
    Description / Table of Contents: Chapter 1. From observing children in traditional upbringing to concepts of health -- Chapter 2. Human evolution, microorganisms, socioeconomic status and reconciling necessary microbial exposures with essential hygiene -- Chapter 3. Biodiversity, microbiomes, and human health -- Chapter 4. Regulation of host immunity by the gut microbiota -- Chapter 5. The gut microbiota and host metabolism -- Chapter 6. The impacts of the microbiota on animal development and physiology -- Chapter 7. The development of the gut microbiota in childhood, and its distortion by lifestyle changes -- Chapter 8. Distortion of the microbiota of the natural environment by human activities -- Chapter 9. The nature and functions of vertebrate skin microbiota -- Chapter 10. The influence of the microbiota on brain structure and function: Implications for stress-related neuropsychiatric disorders -- Chapter 11. Neurodegenerative diseases and the gut microbiota -- Chapter 12. Clinical application of the biodiversity hypothesis in the management of allergic disorders. .
    Abstract: This edited collection of 12 chapters by research workers from a wide range of disciplines resolves the confusion that currently surrounds the “hygiene hypothesis” by considering the human need for exposure to microorganisms from an evolutionary point of view. The book explains why we evolved a requirement for exposure to microbiota from our mothers, from other people, and from the natural environment. It also explains the physiological roles of these exposures, what goes wrong when the exposures are distorted and how human lifestyles and activities, including degradation of the natural environment, are leading to this distortion. Particular attention is given to the range of pathologies associated with inappropriate microbial exposures and inappropriate colonization, including immunoregulatory problems such as allergies and autoimmunity, metabolic problems such as obesity and diabetes, and problems of central nervous system function and neurodegeneration. This book is of profound relevance to most medical disciplines, but also to those concerned with preserving the natural environment and with developing healthier urbanisation.
    Type of Medium: Online Resource
    Pages: X, 414 p. 46 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030910518
    Series Statement: Progress in Inflammation Research, 89
    URL: https://doi.org/10.1007/978-3-030-91051-8
    DOI: 10.1007/978-3-030-91051-8
    DDC: 571.96
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    mRNA Vaccines (2022)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Pharmacology. ; Internal medicine. ; Clinical biochemistry. ; Immunology. ; Pharmacology. ; Internal Medicine. ; Medical Biochemistry.
    Description / Table of Contents: Preface -- mRNA-based vaccines and mode of action -- Self-Amplifying mRNA-Based Vaccine Technology and its Mode of Action -- Formulation and Delivery Technologies for mRNA Vaccines -- Messenger RNA-based vaccines against infectious diseases -- Emerge gate for Therapeutics applications of mRNA based drug -- Clinical Development of mRNA Vaccines: Challenges and Opportunities -- Regulatory Considerations on the Development of mRNA Vaccines.
    Abstract: The formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume. The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies. Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches. Consequently, the development progress of the technology, particularly on production, capabilities, and clinical development is reviewed. Topics on safety, regulatory issues, and possible challenges to the mRNA vaccination approach round off this book. Thanks to their high potency, the prospect for generic, low-cost manufacturing processes, and entirely synthetic nature, the future for mRNA vaccines is highly promising. Importantly, mRNA vaccines have the potential to minimize the time between pathogen identification and vaccine release with a huge impact on public health. As the mRNA-based vaccination technology has been progressing rapidly, the book is intended to be an end-to-end review series, covering everything from basic RNA biology and preclinical studies to the manufacturing strategy, clinical development and regulatory approval. It provides established RNA researchers and developers with updates on the latest advancements in the field and allows for a quick but comprehensive overview of this transformative technology, its application, and future potential.
    Type of Medium: Online Resource
    Pages: XI, 205 p. 8 illus., 7 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031180705
    Series Statement: Current Topics in Microbiology and Immunology, 437
    URL: https://doi.org/10.1007/978-3-031-18070-5
    DOI: 10.1007/978-3-031-18070-5
    DDC: 571.96
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    Current Advances in Osteosarcoma : Clinical Perspectives: Past, Present and Future (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medical microbiology. ; Cytology. ; Pediatrics. ; Cancer Biology. ; Medical Microbiology. ; Cell Biology. ; Pediatrics.
    Description / Table of Contents: Adjuvant and Neoadjuvant Chemotherapy for Osteosarcoma: A Historical Perspective -- Part 1: Surgical Considerations and Outcomes -- Limb Salvage and Reconstruction Options in Osteosarcoma -- Advances in the functional assessment of patients with sarcoma -- Part II: Novel Therapeutic Approaches Based on Biology -- Radiopharmaceuticals for Treatment of Osteosarcoma -- HER-2 Targeted Therapy in Osteosarcoma -- Aerosolized Chemotherapy for Osteosarcoma -- The Histone Deacetylase inhibitor Entinostat/Syndax 275 in Osteosarcoma -- Relapsed Osteosarcoma Trial Concepts to Match the Complexity of the Disease -- Using liquid biopsy in the treatment of patient with osteosarcoma -- Part III: Novel Immunotherapeutic Approaches -- Genetically modified T-cell therapy for osteosarcoma: into the roaring 2020’s -- Muramyl Tripeptide-Phosphatidyl Ethanolamine Encapsulated in Liposomes (L-MTP-PE) in the Treatment of Osteosarcoma -- Natural Killer Cell Immunotherapy for Osteosarcoma -- Nanocapsule delivery of IL-12 -- Discovery of cell surface vimentin (CSV) as a sarcoma target and development of CSV-targeted IL-12 immune therapy -- Part IV: Survivorship and Late Effects -- Editorial Comments on late effects -- Anthracycline-Induced Cardiotoxicity: Causes, mechanisms & prevention -- Exercise and Physical Activity in Patients with Osteosarcoma and Survivors -- Index.
    Abstract: This thoroughly revised second edition complied in 2 books is an up-to-date overview of the current clinical advances in sarcoma and osteosarcoma. The new edition features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, these essential volumes also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists focused in sarcoma.
    Type of Medium: Online Resource
    Pages: XIII, 212 p. 24 illus., 17 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030430320
    Series Statement: Advances in Experimental Medicine and Biology, 1257
    URL: https://doi.org/10.1007/978-3-030-43032-0
    DOI: 10.1007/978-3-030-43032-0
    DDC: 571.978
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    Natural Products for Cancer Chemoprevention : Single Compounds and Combinations (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Cancer Biology.
    Description / Table of Contents: Chapter 1. Chemoprevention of Cancer - Past,Present, and Future -- Chapter 2. Resveratrol for Cancer Prevention: Current Gaps and Opportunities -- Chapter 3. Pterostilbene as a Potent Chemopreventive Agent in Cancer -- Chapter 4. Pharmacokinetics and Bioavailability Enhancement of Natural Products -- Chapter 5. Vitamin D Compounds and Cancer Stem Cells in Cancer Prevention -- Chapter 6. Anti-cancer Effects of Silibinin – The Current Status in Cancer Chemoprevention -- Chapter 7. Adjuvant Value of Turmeric Extract (Containing Curcumin) in Colorectal Cancer Management -- Chapter 8. Cancer Prevention by Tea Polyphenols -- Chapter 9. The Chemopreventive Power of Isothiocyanates -- Chapter 10. Xanthohumol and Structurally Related Prenylflavonoids for Cancer Chemoprevention and Control -- Chapter 11. Anthocyanins and Cancer Prevention -- Chapter 12. Grape ChemopreventiveAgents AgainstAngiogenesis and Metastasis -- Chapter 13. Punicagranatum L. Constituents for Cancer Prevention, Chemosensitisation and Therapeutic Treatment -- Chapter 14. Cancer ChemopreventivePotential of Epidermal Growth Factor Receptor Inhibitors from Natural Products -- Chapter 15. Anti-cancer Dynamics of Natural Phytochemical Inhibitors of Cyclin-dependent Kinases -- Chapter 16. Pro-apoptotic Properties of Chemopreventive Agents -- Chapter 17. The Use of Anti-inflammatory Agents for Cancer Chemoprevention -- Chapter 18. Combination Chemoprevention by Targeting the Epigenome -- Chapter 19. Perspective – a positive cocktail effect of the bioactive components in the diet.
    Abstract: This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research. .
    Type of Medium: Online Resource
    Pages: XX, 629 p. 59 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030398552
    URL: https://doi.org/10.1007/978-3-030-39855-2
    DOI: 10.1007/978-3-030-39855-2
    DDC: 571.978
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    Inducible Lymphoid Organs (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Diseases. ; Cancer. ; Human physiology. ; Immunology. ; Diseases. ; Cancer Biology. ; Human Physiology.
    Description / Table of Contents: Basics of Inducible Lymphoid Organs -- Role of iBALT in respiratory immunity -- Chronic inflammation in mucosal tissues: Barrier integrity, inducible lymphoid tissues, and immune surveillance -- Role of lymphoid structure in skin immunity -- Memory lymphocyte clusters in genital immunity: Role of tissue-resident memory T cells (TRM) -- Ectopic lymphoid tissue in Rheumatoid Arthritis -- Artificial construction of immune tissues/organoids and their application for immunological intervention.
    Abstract: This book sheds new light on “inducible” lymphoid organs (ILOs): antigen presentation sites that are generated de novo in peripheral tissues under various pathogenic conditions. Accomplished immunologists demonstrate that the physiological role of these ILOs is completely different from that of central lymphoid organs, i.e., the lymph nodes or spleen. In addition to the central organs, the ILOs are considered essential structures for the efficient elicitation of adaptive immune responses in lesions. The respective chapters highlight examples from multiple sites, e.g. the skin, lung, intestinal tract, genital tract, the synovial membrane of the joints and artificial lymph nodes. Accordingly, readers will learn that ILO structure and function can vary substantially, depending on the context. Presenting the results of the latest immunological research, the book offers a fascinating and insightful read for both scientists and clinicians in the areas of infectious and immune-associated diseases.
    Type of Medium: Online Resource
    Pages: VII, 160 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030517472
    Series Statement: Current Topics in Microbiology and Immunology, 426
    URL: https://doi.org/10.1007/978-3-030-51747-2
    DOI: 10.1007/978-3-030-51747-2
    DDC: 571.96
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    Liver Immunology : Principles and Practice (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Immunology.
    Description / Table of Contents: 1. Core Concepts in Immunology: The Definition of Autoimmunity and Its Unique Application to the Seat of Tolerance, the Liver -- 2. The Liver as a Lymphoid Organ -- 3. The Uniqueness of Innate Immunity -- 4. Adaptive Immunity and the Clinical Definition of Autoantibodies.-5. Genetics of Autoimmune Liver Diseases -- 6. The Epigenetic Basis of Loss of Tolerance -- 7. Bile Acids and Bilirubin in Liver Immunology -- 8. The Microbiota-Gut-Liver Axis – Implications for the Pathophysiology of Liver Disease -- 9. Diagnostic Liver Immunology -- 10. The Pathologist’s Approach to Reviewing Liver Histology -- 11. Geoepidemiology of Autoimmune Liver Diseases -- 12. Immune Responses to Bacterial Infections -- 13. Immunity of Parasitic Infections of the Liver -- 14. The Treatment of Bacterial and Parasitic Diseases of the Liver -- 15. Hepatitis A and Other Viral Infections -- 16. Hepatitis B Virus -- 17. Hepatitis C -- 18. Hepatitis D -- 19. Hepatitis E -- 20. Alcohol-Associated Liver Disease -- 21. Non-alcoholic Fatty Liver Disease: A Chapter in Liver Immunology -- 22. Primary Biliary Cholangitis -- 23. PSC – AIH Overlap -- 24. Primary Biliary Cholangitis: Autoimmune Hepatitis Overlap Syndrome -- 25. Primary Sclerosing Cholangitis -- 26. Autoimmune Hepatitis -- 27. IgG4-related Disease: Current Concept, Diagnosis, and Pathogenesis -- 28. Pediatric Liver Disease -- 29. Mechanisms of Acute Liver Failure -- 30. Immune-Mediated Drug-Induced Liver Injury -- 31. Hepatobiliary Cancers and Immunology -- 32. Acute-on-Chronic Liver Failure -- 33. The Pathogenesis of Liver Diseases in Pregnancy -- 34. Graft-Versus-Host Disease -- 35. Immunopathogenesis of Liver Cirrhosis -- 36. Immune-Mediated Liver Disease in the Transplanted Liver.
    Abstract: The third edition of this acclaimed work provides clinicians and investigators with a wealth of state-of-the-art information that will lead to fresh approaches in thinking about liver physiology and liver diseases. Developed by a panel of renowned international authors, this edition outlines a range of important advances in our understanding of the liver’s role as an immune organ and the functions of innate and adaptive immunity in the pathogenesis of all liver diseases. Indeed, the liver is a vitally important immune organ producing liver-derived products that can trigger the innate and adaptive immune system to initiate, mediate, regulate, and resolve systemic inflammation. The book begins with an analysis of the core concepts of immunology, including the definition of autoimmunity and its unique application to the liver, a tolerogenic organ. Subsequent chapters then explore the biological elements of liver diseases caused by epigenetics, genetics, and innate and adaptive immunity. Specific clinical presentations and aspects of liver diseases are also examined, such as Hepatitis C, non-alcoholic fatty liver disease and parasitic infections. Closing chapters then discuss liver diseases among specific populations, including pediatrics, those with comorbidities and preexisting conditions, pregnant women, and finally patients with transplanted organs. A timely and invaluable update to the clinical literature, Liver Immunology: Principles and Practice, Third Edition, is once again a comprehensive work that will not only enhance the understanding of liver diseases but also provide the kind of novel insights that greatly accelerates the evidence-based care of children and adults afflicted with these diseases. This volume is again a must-read for clinicians at all levels, for investigators and for students. .
    Type of Medium: Online Resource
    Pages: XV, 633 p. 145 illus., 135 illus. in color. , online resource.
    Edition: 3rd ed. 2020.
    ISBN: 9783030517090
    URL: https://doi.org/10.1007/978-3-030-51709-0
    DOI: 10.1007/978-3-030-51709-0
    DDC: 571.96
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    Autophagy in Stem Cell Maintenance and Differentiation (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Stem cells. ; Cytology. ; Developmental biology. ; Cancer Stem Cells. ; Cell Biology. ; Developmental Biology and Stem Cells.
    Description / Table of Contents: Assays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.
    Abstract: This book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 41 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031173622
    Series Statement: Stem Cell Biology and Regenerative Medicine, 73
    URL: https://doi.org/10.1007/978-3-031-17362-2
    DOI: 10.1007/978-3-031-17362-2
    DDC: 571.978
    Language: English
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    The Collectin Protein Family and Its Multiple Biological Activities (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical microbiology. ; Proteins . ; Immunology. ; Medical Microbiology. ; Protein Biochemistry.
    Description / Table of Contents: 1. Discovering the role of mannose-binding lectin (MBL) in innate immunity: the early history -- 2. Mannose-binding lectin in human health and disease -- 3. The activities of MASPs, complement proteases associated with collectins and ficolins -- 4. Structures of the MASPs and comparison with C1r and C1s -- 5. Biological activities of SP-A and SP-D against extracellular and intracellular pathogens -- 6. Surfactant protein D: A Therapeutic Target for Allergic Airway Diseases -- 7. SP-D in immune surveillance against cancer -- 8.Testicular immune privilege – a recently discovered domain of Collectins -- 9. Role of Collectins in Pregnancy -- 10. Bovine Collectins: Role in Health and Disease -- .
    Abstract: The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging activities of Collectins, such as: · Their role in metabolism, and therefore their involvement in lifestyle diseases such as obesity and cardiovascular disease. · Their ability to modulate the adaptive immune response, as well as to recognize and trigger apoptosis of cancer cells, which makes them effective in the annihilation of cancer cells with multiple mutations. · The regulation of their expression by gonadal steroid hormones implicates them with critical roles in both male and female fertility. · Altered levels of Collectins have been associated with various autoimmune diseases. This book brings together current knowledge of the structure, functions and biological activities of Collectins, to describe their integral role in human health.
    Type of Medium: Online Resource
    Pages: XII, 244 p. 50 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030670481
    URL: https://doi.org/10.1007/978-3-030-67048-1
    DOI: 10.1007/978-3-030-67048-1
    DDC: 571.96
    Language: English
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    History of Rabies in the Americas: From the Pre-Columbian to the Present, Volume I : Insights to Specific Cross-Cutting Aspects of the Disease in the Americas (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Virology. ; Medicine History. ; Veterinary medicine. ; Vaccines Biotechnology. ; Biomaterials. ; Immunology. ; Virology. ; History of Medicine. ; Veterinary Science. ; Biomaterials-Vaccines.
    Description / Table of Contents: The world in flux – the Columbian Exchange D. Domenici -- Glimpses into the past: new world contributions towards understanding the basic etiology, pathobiology & treatment of rabies, Drishya Kurup et al -- The Diversity, Evolution and Emergence of Rabies Virus in the Americas, Edward C. Holmes & Erin H. Harvey -- The ecological range and principles of wildlife rabies virus perpetuation in the Americas, Amy T. Gilbert -- Historical Laboratory Contributions Supporting Rabies Diagnosis and Disease Prevention and Control in the Americas, Susan A. Nadin-Davis, et al -- Progression from nerve tissue vaccines to recombinant biologics, H. Ertl -- Wildlife Rabies Management in the New World: Prevention, Control and Elimination in Mesocarnivores, R. Chipman et al -- Management of vampire bats and rabies: past, present, and future, Tonie Rocke & Daniel Streicker -- Conflicting Perspectives on a Rabies Outbreak in a Venezuelan Rainforest, 2007-2008, C. Briggs -- Rabies, Medicine, and Culture: Dogs, Disease, and Urban Life in the United States, 1840-1920, Jessica Wang -- Historical disparities in health: rabies surveillance, risk factors and prevention, Amira Roess et al -- The Health Economics of Rabies in the Americas: An Historical Summary and a Synthesis of the Literature, S.A. Shwiff -- Towards the elimination of canine rabies in the americas: governance of a regional program, M. Vigilato et al -- Musing Over Non-technical Criticalities of Rabies Prevention and Control in the Americas, Victor J. Del Rio Vilas & Gilberto Montibeller.
    Abstract: Rabies is one of the oldest known pathogens, is incurable, and has the highest fatality rate of all infectious diseases. The Americas is the only region with bat rabies virus, including vampire bat rabies. The region is rich in cultural references and notable for many discoveries in the field, including the current vaccine potency test, diagnostic assay, conception of oral vaccines for wildlife, the first human survivor and the first successful canine rabies program executed at a broad level. Rabies remains the most important viral zoonosis, with tens of thousands of human fatalities and tens of millions of exposures annually, which can be used to model for other pathogens, such as COVID-19. There is an international effort to eliminate human rabies caused by dogs over the next decade, and the Americas represent the primary region with the greatest proof-of-concept evidence to accomplish this goal. This two-volume set addresses the medical history and modern results of rabies in countries throughout the Americas, including the implications of and on cultural, economic, sociological, and research developments in the region. Volume I presents an overview of concepts critical to the study of rabies in the region, including evolutionary aspects, reservoir ecology and control, elimination efforts, vaccine development, and disease hallmarks and progression. It also analyzes the long-term cultural, social, and economic impacts of the disease in the Americas. .
    Type of Medium: Online Resource
    Pages: XVI, 319 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031250521
    Series Statement: Fascinating Life Sciences,
    URL: https://doi.org/10.1007/978-3-031-25052-1
    DOI: 10.1007/978-3-031-25052-1
    DDC: 571.96
    Language: English
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    Alternative Medicine Interventions for COVID-19 (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Alternative medicine. ; Virology. ; Therapeutics. ; Nutrition   . ; Food science. ; Immunology. ; Complementary and Alternative Medicine. ; Virology. ; Therapeutics. ; Nutrition. ; Food Science.
    Description / Table of Contents: 1. Introduction to COVID-19 -- 2. Medicinal plants as COVID-19 remedy -- 3. Traditional Chinese Medicines as possibly remedy Against SARS- CoV-2 -- 4. Plant natural products against COVID-19 -- 5. Foods as first defense against COVID-19 -- 6. Drugs for the treatment of COVID-19 -- 7. COVID-19 pandemic and vaccines -- 8. Recent updates in vaccine development against COVID-19 -- 9. Recent developments in therapeutic approaches against COVID-19.
    Abstract: This research volume examines the available alternative, complementary, pharmaceutical and vaccine methods for treating, mitigating, or preventing COVID-19. Coverage includes traditional Chinese medicine, herbal remedies, nutraceutical/dietary options, and drug/vaccine therapies. All the methods discussed will be critically examined to provide readers with a full, unbiased overview that includes pros/cons of each method. While the nature of COVID-19 is still being studied, and new research and theories are being published daily, this book endeavors to provide readers with a comprehensive summary of current research on alternative and mainstream treatment and prevention methods. .
    Type of Medium: Online Resource
    Pages: XII, 284 p. 120 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030679897
    URL: https://doi.org/10.1007/978-3-030-67989-7
    DOI: 10.1007/978-3-030-67989-7
    DDC: 571.96
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    Tumor Microenvironment : Hematopoietic Cells – Part B (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Hematopoietic system. ; Cytology. ; Cancer Microenvironment. ; Haematopoietic System. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: Eosinophils in the tumor microenvironment -- Dendritic cells in the tumor microenvironment -- Resident memory T cells in the tumor microenvironment -- NK cells in the tumor microenvironment -- γδ T cells in tumor microenvironment -- Regulatory T Cells in the Tumor Microenvironment -- The Hematopoietic Microenvironment in Myeloproliferative Neoplasms: The Interplay Between Nature (Stem Cells) and Nurture (the Niche) -- Langerhans cells in the tumor microenvironment -- Mast cells in the tumor microenvironment -- B cells in the gastrointestinal tumor microenvironment with a focus on pancreatic cancer: opportunities for precision medicine? -- Microglia in the Brain Tumor Microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include eosinophils, NK cells, γδ T cells, regulatory T Cells, Langerhans cells, hematopoietic stem cells, Mast cells, B cells and Microglia, and more. Taken alongside its companion volumes, Tumor Microenvironment: Hematopoietic Cells – Part B updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIV, 215 p. 26 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030492700
    Series Statement: Advances in Experimental Medicine and Biology, 1273
    URL: https://doi.org/10.1007/978-3-030-49270-0
    DOI: 10.1007/978-3-030-49270-0
    DDC: 571.978
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    Cancer Metabolomics : Methods and Applications (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. NMR-Based Metabolomics in Cancer Research -- 2. Capillary Electrophoresis–Mass Spectrometry for Cancer Metabolomics -- 3. Chemical Isotope Labeling LC-MS for Metabolomics -- 4. Single cell metabolomics by mass spectrometry imaging -- 5. Fatty Acid Metabolism and Cancer -- 6. Metabolomics of Gastric Cancer -- 7. HIF-1α metabolic pathways in human cancer -- 8. Regulation of glycolysis in head and neck cancer -- 9. Metabolomics of oral/head and neck cancer -- 10. Ion chromatography with mass spectrometry for metabolomic analysis -- 11. Methods of lipidomic analysis: Extraction, derivatization, separation and identification of lipids -- 12. Functional metabolomics and chemoproteomics approaches reveal novel metabolic targets for anti-cancer therapy -- 13. Metabolomics of glioma -- 14. Microbial metabolomics: From methods to translational applications -- 15. Advances in the study of N6-methyladenine in eukaryotes -- 16. NMR Based Metabolomics -- 17. Quantitative analysis of oncometabolite 2-hydroxyglutarate -- 18. Tracer-based Cancer Metabolomic Analysis -- 19. Mass spectrometry-based shotgun lipidomics for cancer research -- 20. Comprehensive Two-dimensional Gas Chromatography Mass Spectrometry-based Metabolomics.
    Abstract: Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.
    Type of Medium: Online Resource
    Pages: XV, 312 p. 80 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030516529
    Series Statement: Advances in Experimental Medicine and Biology, 1280
    URL: https://doi.org/10.1007/978-3-030-51652-9
    DOI: 10.1007/978-3-030-51652-9
    DDC: 571.978
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    Resistance to Targeted Therapies in Multiple Myeloma (2021)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Immunology. ; Cancer Biology. ; Immunology.
    Description / Table of Contents: 1. The role of targeted therapy in multiple myeloma -- 2. Lenalidomide -- 3. Pomalidomide -- 4. Mechanisms driving resistance to proteasome inhibitors bortezomib, carfilzomib and ixazomib in multiple myeloma -- 5. Daratumumab -- 6. Elotuzumab -- 7. Histone deacetylase inhibitors -- 8. Bone targeted therapies -- 9. New targeted therapies for multiple myeloma under clinical investigation.
    Abstract: Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.
    Type of Medium: Online Resource
    Pages: XVII, 154 p. 5 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030734404
    Series Statement: Resistance to Targeted Anti-Cancer Therapeutics, 22
    URL: https://doi.org/10.1007/978-3-030-73440-4
    DOI: 10.1007/978-3-030-73440-4
    DDC: 571.978
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    Advances in Host-Directed Therapies Against Tuberculosis (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Diseases. ; Therapeutics. ; Immunology. ; Diseases. ; Therapeutics.
    Description / Table of Contents: Section 1: Introduction -- Chapter 1: Introduction: An overview of host-directed therapies for tuberculosis -- Section 2: Targeting immunometabolism -- Chapter 2: Sirtuin deacetylases: Linking Mycobacterial infection and host metabolism -- Chapter 3:The mammalian target of rapamycin complex 1 (mTORC1): an ally of M. tuberculosis in host cells -- Chapter 4: HIF-1α as a potential therapeutic target for tuberculosis treatment -- Chapter 5: Nuclear receptors in host-directed therapies against tuberculosis -- Section 3: Enhancing anti-mycobacterial mechanisms -- Chapter 6: Autophagy as a target for host-directed therapy against tuberculosis -- Chapter 7: Metformin: a leading HDT candidate for TB -- Chapter 8: Statins as host-directed therapy for tuberculosis -- Chapter 9: Antimycobacterial attributes of mitochondria: An insight into host defense mechanisms -- Section 4: Targeting immune cells -- Chapter 10: Conventional and unconventional lymphocytes in immunity against Mycobacterium tuberculosis -- Chapter 11: Targeting inhibitory cells such as Tregs and MDSCs in the tuberculous granuloma -- Chapter 12: Targeting suppressor T cells -- Chapter 13: Neutrophil-mediated mechanisms as targets for host-directed therapies against tuberculosis -- Chapter 14: Type I interferon and interleukin-1 driven inflammatory pathways as targets for HDT in tuberculosis -- Chapter 15: Mucosal-associated invariant and Vγ9Vδ2 T cells -- Chapter 16: Airway epithelial cells.-Section 5: Preclinical models for assessing HDTs -- Chapter 17: In vitro models of human granuloma formation to analyze host-directed therapies -- Chapter 18: C3HeB/FeJ as a key mouse strain for testing host-directed therapies against tuberculosis -- Chapter 19: The Rabbit Model for Assessing Host-Directed Therapies for Tuberculosis -- Section 6: Clinical trials of HDTs and special considerations for study endpoints -- Chapter 20:Clinical trials of TB-HDT candidates -- Chapter 21:Outcomes for clinical trials of host-directed therapies for tuberculosis -- Chapter 22: Pharmacological considerations for clinical trials of host-directed therapies for tuberculosis.
    Abstract: This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the reader will derive from learning about the biology of multiple host pathways involved in health and disease, how these pathways are disrupted or dysregulated during tuberculosis, and which druggable targets exist in these pathways. This book provides the reader with a roadmap of current and future directions of HDT against tuberculosis. Since the host pathways/factors involved in protective or maladaptive responses to tuberculosis are not disease-specific, information learned from the context of tuberculosis likely will be relevant to other infectious and non-infectious diseases.
    Type of Medium: Online Resource
    Pages: XIII, 332 p. 20 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030569051
    URL: https://doi.org/10.1007/978-3-030-56905-1
    DOI: 10.1007/978-3-030-56905-1
    DDC: 571.96
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    Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Oncology. ; Cancer Biology. ; Oncology.
    Description / Table of Contents: Role of specific phytochemicals against gastrointestinal malignancies -- Role of phytochemicals on growth and metastasis of GI cancer -- Cancer Stem Cells as Therapeutic Targets for Gastrointestinal cancers -- Phytochemicals plus checkpoint inhibitors in GI cancers -- Crucial role of curcumin on gut microbiota associated with GI cancers -- Cellular and Molecular mechanisms of garlic compounds in common GI cancers -- Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy -- Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer -- Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors -- Therapeutic Efects Of Curcumin Against Colorectal Cancer -- Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes -- Role of Dietary Supplementation of Natural products in the Prevention and Treatment of Liver Diseases -- Emerging Roles of Phytochemicals in Hepatocellular Carcinoma -- Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma -- Index.
    Abstract: Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
    Type of Medium: Online Resource
    Pages: XI, 340 p. 22 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030484057
    URL: https://doi.org/10.1007/978-3-030-48405-7
    DOI: 10.1007/978-3-030-48405-7
    DDC: 571.978
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    Notch Signaling in Embryology and Cancer : Notch Signaling in Cancer (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword -- Transcription factor RBPJ as a molecular switch in regulating the Notch response -- Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer -- Notch and endometrial cancer -- Notch and Esophageal Squamous Cell Carcinoma -- Notch signaling and liver cancer -- Notch inHead and Neck Cancer -- Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis -- The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond -- Notch Signaling in Thyroid Cancer -- The Relevance of Notch Signaling in Cancer Progression -- Notch Signaling and the Breast Cancer Microenvironment -- Notch pathway: a journey from notching phenotypes to cancer immunotherapy -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books -- Notch Signaling and Embryologic Development and Molecular Basis of Notch Signaling – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students.
    Type of Medium: Online Resource
    Pages: XVII, 228 p. 28 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030550318
    Series Statement: Advances in Experimental Medicine and Biology, 1287
    URL: https://doi.org/10.1007/978-3-030-55031-8
    DOI: 10.1007/978-3-030-55031-8
    DDC: 571.978
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    Close Encounters of the Microbial Kind : Everything You Need to Know About Common Infections (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical sciences. ; Virology. ; Diseases. ; Patient education. ; Immunology. ; Health Sciences. ; Virology. ; Diseases. ; Patient Education.
    Description / Table of Contents: 1. Microbes and infectious diseases -- 2. Acne -- 3. Skin abscesses (boils) -- 4. Dandruff -- 5. Fungal nail infections -- 6. Fungal infections of the skin -- 7. Chickenpox -- 8. Shingles -- 9. Common warts -- 10. The common cold -- 11. Influenza -- 12. Sore throat -- 13. Coronavirus disease-2019 -- 14. Acute sinusitis -- 15. Chronic sinusitis -- 16. Otitis media (middle ear infection) -- 17. Otitis externa (swimmers ear) -- 18. Acute bronchitis (chest cold) -- 19. Conjunctivitis (pink eye) -- 20. Tooth decay (caries) -- 21. Gum disease -- 22. Bad breath -- 23. Oral thrush -- 24. Oral herpes -- 25. Cystitis (lower urinary tract infection) -- 26. Vaginitis -- 27. Chlamydia -- 28. Gonorrhoea -- 29. Genital herpes -- 30. Genital warts -- 31. Syphilis -- 32. Gastroenteritis due to Campylobacter -- 33. Gastroenteritis due to Salmonella -- 34. Gastroenteritis due to Clostridium perfringens -- 35. Gastroenteritis due to Norovirus -- 36. Gastroenteritis due to Rotavirus.
    Abstract: Microbes – can’t live with them, can’t live without them. Increasingly, we’re finding out that our microbiota (the microbes that live on us) are essential for our wellbeing – they provide us with nutrients and vitamins and play a key role in developing our immune system. On the other hand, they are responsible for a great deal of misery, as they are major causes of death and debility around the world. As well as our own microbiota turning against us, there are lots of other microbes out in the wider world that can seriously damage, or even kill, those they infect. The current pandemic of COVID-19 shows the devastating effect that an infectious disease can have – our lives have been turned upside down. If you live in a developed country, you’re not likely to get killer diseases such as ebola and cholera, but you do have a high chance of catching other infections that can have a significant impact on your wellbeing. This book focuses on those infections you’re most likely to go down with, and supplies the answers to the following questions about them: Which infectious diseases are we likely to come across? How common are they? What microbes cause them? What happens to our bodies during an infection? How are the resulting illnesses treated? How can we avoid getting them? This book covers nearly 60 infectious diseases that people living in developed countries are likely to experience at some point during their life. It also has an introductory chapter that describes, in everyday language, the basic principles of microbiology and infectious diseases. Each chapter is lavishly illustrated, has interesting, relevant inserts, and provides a list of web-accessible suggestions for further reading.
    Type of Medium: Online Resource
    Pages: XV, 526 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030569785
    URL: https://doi.org/10.1007/978-3-030-56978-5
    DOI: 10.1007/978-3-030-56978-5
    DDC: 571.96
    Language: English
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    Tumor Microenvironment : Novel Concepts (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Cancer Microenvironment. ; Cell Biology. ; Cancer Biology.
    Description / Table of Contents: 1. The Tumour Microenvironment and Circulating Tumour Cells: A partnership driving metastasis and glycan-based opportunities for cancer control -- 2. Dormancy in the Tumor Microenvironment -- 3. Tumor-associated tertiary lymphoid structures: A cancer biomarker and a target for next-generation immunotherapy -- 4. Studying the tumor microenvironment in zebrafish -- 5. Pre-metastatic niche formation by neutrophils in different organs -- 6. Tumor cell invasion and the tumor microenvironment: Special focus on brain tumors -- 7. The dog as a model to study the tumor microenvironment -- 8. EFFEROCYTOSIS AND THE STORY OF “FIND ME’’, ‘’EAT ME” AND “DON’T EAT ME” SIGNALING IN THE TUMOR MICRO ENVIRONMENT -- 9. Color-coded imaging of the tumor micro-environment (TME) in human patient-derived orthotopic xenograft (PDOX) mouse models -- 10. Mitochondria and the tumor microenvironment in blood cancer -- 11. Telocytes in the tumor microenvironment -- 12. Modeling the roles of astrocytes in the metastatic tumor cell microenvironment -- 13. Roles of fibroblasts in microenvironment formation associated with radiation-induced cancer -- 14. Tumor microenvironment-associated pericyte populations may impact therapeutic response in thyroid cancer -- 15. The adrenergic nerve network in cancer -- 16. Current treatment modalities targeting tumor microenvironment in castration-resistant prostate cancer -- 17.Brain metastases and tumor microenvironment -- 18. MIGRATION STIMULATING FACTOR (MSF). ITS ROLE IN THE TUMOUR -- MICROENVIRONMENT -- 19. Mechanical Signaling in the Mammary Microenvironment - from Homeostasis to Cancer -- 20. Osteopontin Signaling in Shaping Tumor Microenvironment Conducive to Malignant Progression -- 21. Progesterone receptor signaling in the breast tumor microenvironment -- 22. Progranulin/GP88, a complex and multi-faceted player of tumor growth by direct action and via the tumor microenvironmen -- 23. Sex-based differences in the tumor microenvironmet. .
    Abstract: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XIII, 548 p. 79 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030731199
    Series Statement: Advances in Experimental Medicine and Biology, 1329
    URL: https://doi.org/10.1007/978-3-030-73119-9
    DOI: 10.1007/978-3-030-73119-9
    DDC: 571.978
    Language: English
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    Microbial Pathogenesis : Infection and Immunity (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Pharmacology. ; Internal medicine. ; Immunology. ; Pharmacology. ; Internal Medicine.
    Description / Table of Contents: 1.Human Papillomavirus-associated cancers -- 2. Mechanisms of immune evasion by Ebola virus -- 3. Innate immune mechanisms against HIV-1 -- 4. Current insights into the host immune response to respiratory viral infections -- 5. Immune responses to MERS-CoV in humans and animals -- 6. SARS-CoV-2: Pathogenesis and host-pathogen interaction -- 7. Antibiotic Resistance mechanisms and their transmission in Acinetobacter baumannii -- 8. Pathogenesis and host immune response in leprosy -- 9. Innate immunity and tuberculosis -- 10. Vaccination strategies against Mycobacterium tuberculosis: BCG and beyond -- 11. Candida pathogenicity and interplay with the immune system -- 12. Immune responses in Malaria and vaccine strategies.
    Abstract: This book updates in detail the microbial pathogenesis of various important pathogens, including HIV-1, MERS, SARS-CoV-2, Mycobacterium and Plasmodium. There is also a general discussion of the innate and adaptive immune responses against primary and opportunistic infections. The overall purpose of the book is to aid in the development of anti-viral and anti-microbial targets.
    Type of Medium: Online Resource
    Pages: XIII, 291 p. 35 illus., 33 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030674526
    Series Statement: Advances in Experimental Medicine and Biology, 1313
    URL: https://doi.org/10.1007/978-3-030-67452-6
    DOI: 10.1007/978-3-030-67452-6
    DDC: 571.96
    Language: English
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    Tumor Microenvironments in Organs : From the Brain to the Skin – Part B (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Targeting Glioblastoma Tumor Microenvironment -- Recent Advances in Head and Neck Tumor Microenvironment Based Therapy -- Meningioma Tumor Microenvironment -- The microenvironment of tongue cancer -- Laryngeal Tumor Microenvironment -- Esophageal tumor microenvironment -- The pituitary tumours and their tumour specific microenvironment -- Pineal gland tumor microenvironment -- Carotid Body Tumor Microenvironment -- The mammary tumor microenvironment -- Integrated Targeting of Lethal Prostate Tumor Phenotype -- The Many Microenvironments of Ovarian Cancer -- Endometrial tumour microenvironment -- Liver Tumor Microenvironment -- Pancreatic Tumor Microenvironment -- Sweat gland tumor microenvironment -- The tumor microenvironment of bladder cancer -- Tumor microenvironment in penile cancer -- Seminal vesicle tumor microenvironment -- Sarcoma tumor microenvironment -- Tumor Environment of Retinoblastoma, Intraocular Cancer -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment components in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in several organs, including brain, neck, tongue, larynges, esophagus, carotid body, breast, prostate, ovary, endometrium, liver, pancreas, bladder, penis, seminal vesicle, retina, and pituitary, pineal and sweat glands, and more. Taken alongside its companion volumes, Tumor Microenvironments in Organs: From the Brain to the Skin – Part B updates us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XVII, 376 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030590383
    Series Statement: Advances in Experimental Medicine and Biology, 1296
    URL: https://doi.org/10.1007/978-3-030-59038-3
    DOI: 10.1007/978-3-030-59038-3
    DDC: 571.978
    Language: English
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    Tumor Microenvironment : The Role of Chemokines – Part B (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Proteins . ; Internal medicine. ; Cancer Microenvironment. ; Cancer Biology. ; Cell Biology. ; Protein Biochemistry. ; Internal Medicine.
    Description / Table of Contents: CCL2 in the tumor microenvironment -- CXCL3 signaling in the tumor microenvironment -- CXCL8 Signaling in the Tumor Microenvironment -- CXCL11 signaling in the tumor microenvironment -- CXCL12 signaling in the tumor microenvironment -- CXCL13 signaling in the tumor microenvironment -- CCL24 signaling in the tumor microenvironment -- CCL25 signaling in the tumor microenvironment -- CCL27 signaling in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of chemokines in the tumor microenvironment. Each chapter focuses on the chemokines patterns of expression, their regulation, and their roles in immune cell recruitment, as well as how they affect cancer immunity and tumorigenesis. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Chemokines – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as apprises us on future directions in the field. This book is essential reading for advanced cell biology and cancer biology students as well as scientists seeking an update on recent developments and research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: IX, 139 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030626587
    Series Statement: Advances in Experimental Medicine and Biology, 1302
    URL: https://doi.org/10.1007/978-3-030-62658-7
    DOI: 10.1007/978-3-030-62658-7
    DDC: 571.978
    Language: English
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    The Future of Prevention and Treatment of Breast Cancer (2021)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Biomedical Research.
    Description / Table of Contents: 1. Defining breast cancer -- 2: Breast Cancer Recurrence and Survival -- 3: Synopsis of the Treatment of Breast Cancer -- 4: The Present Treatment of Hereditary Breast Cancer -- 5: Basis for the Epigenetic Treatment of Triple Negative Breast Cancer -- 6: A New Treatment Strategy foe BRCA1 Related Breast Cancer -- 7: Present Options in the Prevention of Breast Cancer -- 8: The Physiological Basis of Breast Cancer Prevention -- 9: The Present and Future of Screening in Breast Cancer Prevention -- 10: A Vision of the Future.
    Abstract: The objective of this book is to provide a critical analysis of the present prevention strategies for breast cancer, emphasizing the cost benefits and quality of life of the patient. Rooted in the present knowledge of breast cancer biology and prevention and treatment options, the book will describe the future tools that could be available to oncologists and how these new approaches may change the landscape of recurrence and survival of the disease. Special emphasis will be given to the prevention strategies counterposing the present limitations and conflicting prevention guidelines for both hereditary and preventive non-hereditary breast cancer, and propose how the implementation of new strategies based on the present knowledge could save millions of lives and be more cost efficient. The book will present a critical status of the treatment and prevention of breast cancer and detail how a quantum leap could be achieved in the field by applying present basic research knowledge to clinical application.
    Type of Medium: Online Resource
    Pages: XI, 192 p. 41 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030728151
    URL: https://doi.org/10.1007/978-3-030-72815-1
    DOI: 10.1007/978-3-030-72815-1
    DDC: 571.978
    Language: English
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    Healthy Longevity and Immune System (2022)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Aging. ; Neurosciences. ; Nutrition   . ; Medical sciences. ; Immunology. ; Ageing. ; Neuroscience. ; Nutrition. ; Health Sciences.
    Description / Table of Contents: Introduction -- Changes in primary and secondary lymphoid organs (bone marrow, thymus, lymph nodes, spleen) -- Immune barriers (skin, mucosa) -- Innate immunity (neutrophils, monocytes, macrophages) -- Adaptive immunity (T and B lymphocytes: naïve, effector and memory phenotypes and functions) -- ReIntroduction -- Changes in primary and secondary lymphoid organs (bone marrow, thymus, lymph nodes, spleen) -- Immune barriers (skin, mucosa) -- Innate immunity (neutrophils, monocytes, macrophages) -- Adaptive immunity (T and B lymphocytes: naïve, effector and memory phenotypes and functions) -- Regulatory/suppressive cells (Treg, MDSC) -- Infections - Flu, pneumonia, COVID -- Vaccine responses -- Cancer -- Neurodegenerative disease -- Lifestyle/Interventions(physical activity, nutrition, supplements). .
    Abstract: This book presents studies of the main conditions that affect health and well-being of old people. Considering the present scenario of COVID-19, the effects of this viral infection on individuals older than 65 years are also discussed. The content enables professionals of health and government for the present and future actions in this important area. Readers go through the changes occurring in organs and tissues that can interfere with susceptibility to infections, low response to vaccines, cancer, and loss of cognition during the aging process. A discussion of the central role played by the immune system in the age-related diseases and how the immunity can be impaired during the ageing process is presented. Possibilities to circumvent these conditions via healthy habits in diet, physical exercise, and new pharmacological interventions are part of the content. This book discusses how human healthy longevity is dependent, at least in part, of a functional immune system. Chapters were written for researchers in the field of aging and is especially suited for those interested in the study of immunosenescence and inflammaging affecting the health of old individuals.
    Type of Medium: Online Resource
    Pages: X, 199 p. 10 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030875329
    Series Statement: Healthy Ageing and Longevity, 16
    URL: https://doi.org/10.1007/978-3-030-87532-9
    DOI: 10.1007/978-3-030-87532-9
    DDC: 571.96
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    Evolutionary Dynamics of Malignancy : The Genetic and Environmental Causes of Cancer (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Animal models. ; Cancer Treatment. ; Cancer Genetic aspects. ; Cancer Biology. ; Cancer Models. ; Cancer Therapy. ; Cancer Genetics and Genomics. ; Cancer Microenvironment.
    Description / Table of Contents: Chapter 1: Cancer as a Disease of Cell Proliferation -- Chapter 2: Genetic and Chromosomal Instability -- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function -- Chapter 4: The DNA Damage Checkpoint -- Chapter 5: Dynamics of the Spindle Assembly Checkpoint -- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance -- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy -- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy -- Chapter 9: The Cancer Stem Cell and Tumour Progression -- Chapter 10: Evading the antitumour immune response -- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention -- Chapter 12: In science, all conclusions are provisional.
    Abstract: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIV, 269 p. 96 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031325731
    URL: https://doi.org/10.1007/978-3-031-32573-1
    DOI: 10.1007/978-3-031-32573-1
    DDC: 571.978
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    The M2 Macrophage (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Cytology. ; Lipids. ; Diseases. ; Human physiology. ; Immunology. ; Cell Biology. ; Lipidology. ; Diseases. ; Human Physiology.
    Description / Table of Contents: Chapter 1. Introduction. What is an M2 macrophage? Historical overview of the macrophage polarization model. The Th1/Th2 and M1/M2 paradigms, the arginine fork -- Chapter 2. Evolutionary origin of the M2 macrophage activation: invertebrates -- Chapter 3. Evolution of M2 macrophage functions in chordates -- Chapter 4. Signal mechanisms of M2 macrophage activation -- Chapter 5. Mechanisms which control the size of M2 macrophage-dominated tissue macrophage niches -- Chapter 6.Immune functions of the M2 macrophages: host defense, self-tolerance and autoimmunity -- Chapter 7. M2 macrophages in the integument and in the musculoskeletal system -- Chapter 8. M2 macrophages in the circulatory-, respiratory and excretory organs -- Chapter 9. M2 macrophages in the metabolic organs and in the neuroendocrine system -- Chapter 10. Practical approaches in M2 macrophage biology: analysis, pharmacology and didactical interpretation of M2 macrophage functions.
    Abstract: Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.
    Type of Medium: Online Resource
    Pages: XIII, 224 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030504809
    Series Statement: Progress in Inflammation Research, 86
    URL: https://doi.org/10.1007/978-3-030-50480-9
    DOI: 10.1007/978-3-030-50480-9
    DDC: 571.96
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    Tumor Microenvironment : The Main Driver of Metabolic Adaptation (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Immunology. ; Human physiology. ; Cytology. ; Cancer Biology. ; Biomedical Research. ; Medical Genetics. ; Immunology. ; Human Physiology. ; Cell Biology.
    Description / Table of Contents: Preface -- Tumor microenvironment a job of several holders -- Tumor microenvironment- a selective pressure boosting cancer -- Lactate and lactate transporters as key players in the maintenance of the Warburg effect -- Section 1. Adaptive metabolic features are sustained by tumor microenvironment -- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis -- Gut microbiota and cancer of the host: colliding interests -- Metabolic plasticity of tumor cells: how they do adapt to food deprivation -- Multifaceted oncogenic role of adipocytes in the tumour microenvironment -- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology -- Monocytes and macrophages in cancer: unsuspected roles -- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression -- Microenvironment driven metabolic adaptation in melanoma -- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis -- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt -- The bone marrow niche - the tumor microenvironment that ensures leukemia progression -- Section 3. Metabolic fitness and therapy response in cancer -- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer -- The metabolic remodelling in lung cancer and its putative consequence in therapy response -- Hydrogen sulfide metabolism and signaling in the tumor microenvironment -- Using metabolic adaptation to design new drugs -- Metabolomics- a new way of screening cancer -- NMR as a tool for metabolomics -- Section 5. Animal models- addressing cancer microenvironment -- Animal models to study cancer and its microenvironment -- Modulating the metabolic phenotype of cancer microenvironment -- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae -- Section 6. In vitro and ex vivo cancer models -- In vitro and ex vivo models- the tumor microenvironment in a flask -- Index.
    Abstract: This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.
    Type of Medium: Online Resource
    Pages: VII, 443 p. 63 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030340254
    Series Statement: Advances in Experimental Medicine and Biology, 1219
    URL: https://doi.org/10.1007/978-3-030-34025-4
    DOI: 10.1007/978-3-030-34025-4
    DDC: 571.978
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    Next Generation Kinase Inhibitors : Moving Beyond the ATP Binding/Catalytic Sites (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cancer Biology.
    Description / Table of Contents: Chapter 1: Introduction to Kinases, Cellular Signaling, and Kinase Inhibitors -- Chapter 2: Overview of Current Type I/II Kinase Inhibitors -- Chapter 3: Avoiding or Co-opting ATP Inhibition: Type III, IV, V, and VI Kinase Inhibitors -- Chapter 4: Structural Features Regulating Kinase Interactions with Regulatory and Substrate Proteins -- Chapter 5: Developing Kinase Inhibitors using Computer-Aided Drug Design Approaches -- Chapter 6: A Toolbox of Structural Biology and Enzyme Kinetics Reveals the Case for ERK Docking Site Inhibition -- Chapter 7: Novel Stabilized Peptide Inhibitors of Protein Kinases -- Chapter 8: Novel peptide-based inhibitors of protein kinases -- Index.
    Abstract: Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease. .
    Type of Medium: Online Resource
    Pages: XII, 217 p. 59 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030482831
    URL: https://doi.org/10.1007/978-3-030-48283-1
    DOI: 10.1007/978-3-030-48283-1
    DDC: 571.978
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    Food and the Immune System : Molecular Mechanisms and Nutritional Relevance in Health and Disease (2023)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Food science. ; Nutrition   . ; Immunology. ; Food Science. ; Nutrition.
    Abstract: Nutrition is an important environmental factor for the maturation of the human immune system and essential for maintaining immunological homeostasis. Based on this, a variety of food applications with medical claims are being generated by food manufacturers worldwide in order to expand the market potential of products creating interesting linkages with other market segments, such as cosmetics and pharmaceuticals. However, in addition to the health benefits, active principles of such components often remain unexplored. This book focusses on the specific interactions between food ingredients and the immune system along the entire immune defense response. Starting from the immune barrier, through the innate and adaptive immune response, to active limitation and termination, all major mechanisms of the immune response are addressed and different biochemical, cellular and genetic interactions of components of our diet are discussed. The book presents a wealth of disease patterns for which nutritional factors are relevant and thereby provides indications for potential intervention strategies. In addition, associated food-technological aspects are discussed. Being the first of its kind, this book provides an overview of the variety of functional food components and their influence on immunological responses. Written in an accessible style, it addresses researchers, health professionals and students with different scientific backgrounds. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Type of Medium: Online Resource
    Pages: XXIII, 241 p. 73 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031115233
    URL: https://doi.org/10.1007/978-3-031-11523-3
    DOI: 10.1007/978-3-031-11523-3
    DDC: 571.96
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    C-Type Lectins in Immune Homeostasis (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Diseases. ; Proteins. ; Human physiology. ; Cancer. ; Immunology. ; Diseases. ; Proteins. ; Human Physiology. ; Cancer Biology.
    Description / Table of Contents: C-type lectin receptors in phagocytosis -- C-type lectins in immunity to lung pathogens -- Signalling C-type lectins in antifungal immunity -- Dendritic cell immunoactivating receptor: an activating receptor for mycobacteria -- myeloid C-type lectin receptors sensing tissue damage -- 3D structure and ligand recognition of C-type lectins -- Mechanisms and Functions of CARD9 Signaling in the Innate Immune System.
    Abstract: This book focuses on C-type lectin receptors, a newly emerging family of pattern-recognition receptors (PRRs) and a crucial part of the human innate immune system. Above all, the authors highlight these receptors’ role in the recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) – one of the first steps in responding to foreign and potentially dangerous structures in the human body. The respective chapters chiefly examine various C-type lectin receptors, their corresponding ligands, and signalling. In addition to offering immunologists and clinicians important insights from the latest research, they may also provide novel points of departure for future drug development.
    Type of Medium: Online Resource
    Pages: V, 203 p. 60 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030622374
    Series Statement: Current Topics in Microbiology and Immunology, 429
    URL: https://doi.org/10.1007/978-3-030-62237-4
    DOI: 10.1007/978-3-030-62237-4
    DDC: 571.96
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    Complex Systems and Computational Biology Approaches to Acute Inflammation : A Framework for Model-based Precision Medicine (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Bioinformatics. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: 1. An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine -- 2 Translational Equation-based Modeling -- 3. Agent-based Modeling in Translational Systems Biology -- 4. Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -- 5. Therapeutics as Control: Model-based approaches for control discovery -- 6. Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -- 7. Multi-scale equation-based models: Insights for Inflammation and Physiological Variability -- 8. In silico Trials and Personalized Therapy for Sepsis and Trauma -- 9. Computational Modeling of the Coagulation Response -- 10. Disorder of Localized Inflammation in Wound Healing -- 11. Equation-based Models of Wound Healing and Collective Cell Migration -- 12. Agent-based Models of Wound Healing -- 13. Tissue realistic translational modeling of gut inflammation -- 14. Data-Driven Modeling of Liver Injury, Inflammation, and Fibrosis -- 15. Computational Modeling of Tuberculosis -- 16. The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases -- Index.
    Abstract: This second edition expands upon and updates the vital research covered in its predecessor, by presenting state-of-the-art multidisciplinary and systems-oriented approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. In this second edition, we cover both well-established and emerging modeling methods, especially state-of-the-art machine learning approaches and the integration of data-driven and mechanistic modeling. This volume introduces the concept of Model-based Precision Medicine as an alternative approach to the current view of Precision Medicine, based on leveraging mechanistic computational modeling to decrease cost while increasing the information value of the data being obtained. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation: A Framework for Model-based Precision Medicine offers a window into the recent past, the present, and the future of computationally-augmented biomedical research.
    Type of Medium: Online Resource
    Pages: IX, 312 p. 51 illus., 37 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030565107
    URL: https://doi.org/10.1007/978-3-030-56510-7
    DOI: 10.1007/978-3-030-56510-7
    DDC: 571.96
    Language: English
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    Notch Signaling in Embryology and Cancer : Notch Signaling in Embryology (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Cancer. ; Cytology. ; Embryology. ; Cancer Biology. ; Cell Biology. ; Embryology.
    Description / Table of Contents: Notch signalling and embryology: an introduction -- Notch signaling and embryonic development: an ancient friend, revisited -- The Five Faces of Notch Signalling During Drosophila melanogaster Embryonic CNS Development -- Epigenetic regulation of Notch signaling during Drosophila development -- Regulation of proneural wave propagation through a combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion -- A nucleolar protein, Nepro, is essential for the maintenance of early neural stem cells and preimplantation embryos -- The role of Notch signaling in leg development in Drosophila melanogaster -- Notch pathway and inherited diseases: challenge and promise -- Index.
    Abstract: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more. Taken as a whole, with its companion books – Molecular Biology of Notch Signaling and Notch Signaling in Cancer – this is a definitive discussion of the topic, presented by internationally-recognized contributors. Presented in a coherent and accessible structure, this revised and updated second edition is an essential and up-to-date guide for oncologists, embryologists, researchers and advanced students. .
    Type of Medium: Online Resource
    Pages: XIII, 195 p. 16 illus., 5 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030344368
    Series Statement: Advances in Experimental Medicine and Biology, 1218
    URL: https://doi.org/10.1007/978-3-030-34436-8
    DOI: 10.1007/978-3-030-34436-8
    DDC: 571.978
    Language: English
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    Glioma Signaling (2020)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Cytology. ; Proteins. ; Cancer Biology. ; Cell Biology. ; Proteins.
    Description / Table of Contents: Introduction to purinergic signaling in the brain -- Adenosine signaling in glioma cells -- Cross-talk in nucleotide signaling in glioma c6 cells -- Calcium signaling in glioma cells – the role of nucleotide receptors -- Purinergic signaling in glioma progression -- Cytoskeleton and nucleotide signaling in glioma c6 cells -- Signaling determinants of glioma cell invasion -- Receptor tyrosine kinases: principles and functions in glioma invasion -- Recent advances in understanding mechanisms of tgf beta signaling and its role in glioma pathogenesis -- Stat signaling in glioma cells -- Cannabinoid signaling in glioma cells -- Effects of arginine and its deprivation on human glioblastoma physiology and signaling -- Histone modifying enzymes and chromatin modifiers in glioma pathobiology and therapy responses -- Role of infiltrating microglia/macrophages in glioma. .
    Abstract: Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness. The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.
    Type of Medium: Online Resource
    Pages: XI, 305 p. 48 illus., 36 illus. in color. , online resource.
    Edition: 2nd ed. 2020.
    ISBN: 9783030306519
    Series Statement: Advances in Experimental Medicine and Biology, 1202
    URL: https://doi.org/10.1007/978-3-030-30651-9
    DOI: 10.1007/978-3-030-30651-9
    DDC: 571.978
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    Molecular and Cellular Biology of Phagocytosis (2020)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Medicine Research. ; Biology Research. ; Medical microbiology. ; Cytology. ; Biochemistry. ; Immunology. ; Biomedical Research. ; Medical Microbiology. ; Cell Biology. ; Biochemistry.
    Description / Table of Contents: An introduction to phagocytosis -- A Brief History of Phagocytosis -- The role of membrane surface charge in phagocytosis -- Receptor models of phagocytosis: the effect of target shape -- Decision Making in Phagocytosis -- Membrane tension and the role of ezrin during phagocytosis -- Molecular mechanisms of calcium signaling during phagocytosis -- Calpain activation by Ca2+ and its role in phagocytosis -- The NADPH oxidase and the phagosome -- Conclusions and the future of phagocytosis.-.
    Abstract: Phagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably “primitive”) cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the “natural” immunity brought about by immune phagocytes. The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.
    Type of Medium: Online Resource
    Pages: X, 189 p. 66 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030404062
    Series Statement: Advances in Experimental Medicine and Biology, 1246
    URL: https://doi.org/10.1007/978-3-030-40406-2
    DOI: 10.1007/978-3-030-40406-2
    DDC: 571.96
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    Immunology: Overview and Laboratory Manual (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Medicine Research. ; Biology Research. ; Immunology. ; Biomedical Research.
    Description / Table of Contents: Part I: Overview of Immunity -- Ch 1: Immunity -- Ch 2: Components of immunity -- Ch 3: Hematopoiesis -- Ch 4: The Immune system: pathogen sensing and detection -- Ch 5: Lymphoid organs -- Ch 6: Innate and Adaptive immunity -- Ch 7: Leukocyte homing, migration and recirculation -- Ch 8: Apoptosis -- Ch 9: Antigens -- Ch 10: B cell development, activation and immunoglobulin structure -- Ch 11: Immunoglobulin and T cell receptor gene rearrangements -- Ch 12: Major histocompatibility complex proteins -- Ch 13: T cell development and T cell receptor structure -- Ch 14: Cytokines -- Ch 15: Lymphocyte signals -- Ch 16: Complement fixation -- Ch 17: Cell mediated immunity -- Ch 18: Hypersensitivities -- Ch 19: Parasite Immunity -- Ch 20: Vaccines -- Ch 21: Transplantation -- Ch 22: Immune regulation and autoimmunity -- Ch 23: Immunodeficiencies -- Ch 24: Cancer -- Ch 25: Practice questions -- Ch 26: Study guide for exam. Part II. Laboratory Manual -- 27. Immunology laboratory policies -- 28. Instructions for notebook entries -- 29. Instructions for writing lab reports -- 30. Lab report topics -- 31. Exercise 1: Using a compound microscope -- 32. Exercise 2: Pipetting and dilution technique, identification of mouse lymphoid organs -- 33. Exercise 3: Blood Cell Preparation, Leukocyte differentiation and ABO Blood Typing -- 34. Exercise 4: Single Suspension of Mouse Spleen cells, Cell Viability Assays, and Identification of specific cells using surface antigens -- 35. Exercise 5: Isolation of mouse peritoneal macrophages: In vitro phagocytosis of bacterial cells -- 36. Exercise 6: Clearance of bacteria from mouse blood by the RES -- 37. Exercise 7: Hemolytic Plaque assay (The Jeme Plaque Assay) -- 38. EXERCISE 8: Rabbit and Mouse Immunizations- Preparation of Polyclonal antibodies and screening assays -- 39. EXERCISE 9: Determination of Antibody Titer: Screening Techniques -- 40. EXERCISE 10: Immunodiffusion and Immunoelectrophoresis -- 41. EXERCISE 11: Protein Affinity Purification of Rabbit IgG -- 42. EXERCISE 12: Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) -- 43. EXERCISE 13: Immunoblotting (Western Blotting) -- 44. Exercise 14: Protein Assay -- 45. Exercise 15: Enzyme-linked Immunosorbent Assay (ELISA) -- 46. EXERCISE 16: Enzyme-Linked Immunospot Assay (ELISPOT) -- 47. EXERCISE 17: Immunofluorescence assay (IFA) -- 48. EXERCISE 18: Flow Cytometry -- 49.EXERCISE 19: Complement Fixation Assays -- 50. Tissue Cell Culture Techniques -- 51. EXERCISE 20: Mitogen Induced Response of Lymphocytes: Detection of Band T cell Lymphocytes Using Immunofluorescence -- 52. Exercise 21: Induction of IL-2 Secretion from Mouse Lymphoma Cells -- 53. EXERCISE 22: Adoptive Transfer of Lymphocytes: Band T cell Cooperation for Antibody Production -- 54. EXERCISE 23: Macrophage Migration Inhibition -- 55. EXERCISE 24: Monoclonal Antibody Preparation -- 56. EXERCISE 25: Immunization of mice with a recombinant protein -- 57. EXERCISE 26: Polarization of T helper cells into TH1 subset -- 58. Exercise 27: Immunoprecipitation -- 59. EXERCISE 28: Induction of apoptosis in T lymphocytes and detection of apoptotic markers -- 60. EXERCISE 29: Cloning and sequencing of cDNAs of mouse variable regions of H and L chains of monoclonal antibodies -- Appendix -- Sample Practice Questions.
    Abstract: A two-in-one text providing teaching lab students with an overview of immunology as well as a lab manual complete with current standard exercises. Section I of this book provides an overview of the immune system and immunity, and includes review questions, problem sets, case studies, inquiry-based questions, and more to provide students with a strong foundation in the field. Section II consists of twenty-two lab exercises focused on key concepts in immunology, such as antibody production, cell separation, cell function, immunoassays, Th1/Th2 cytokine detection, cell and tissue culture methods, and cell and molecular biology techniques. Appendices include safety information, suggested links and readings, and standard discipline processes, protocols, and instructions.
    Type of Medium: Online Resource
    Pages: XX, 471 p. 61 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030646868
    URL: https://doi.org/10.1007/978-3-030-64686-8
    DOI: 10.1007/978-3-030-64686-8
    DDC: 571.96
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    Microfluidics and Biosensors in Cancer Research : Applications in Cancer Modeling and Theranostics (2022)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Biochemical markers. ; Microfluidics. ; Pharmacology. ; Cancer Treatment. ; Cancer Biology. ; Biomarkers. ; Microfluidics. ; Pharmacology. ; Cancer Therapy.
    Description / Table of Contents: Part 1. Fundamentals of Microfluidics and Biosensors -- Chapter 1. Fundamentals of Biosensors and Detection Methods -- Chapter 2. How to Get Away with Gradients -- Chapter 3. Sensors and Biosensors in Organs-on-a-chip Platforms -- Chapter 4. Current Trends in Microfluidics and Biosensors for Cancer Research Applications -- Part 2. Modelling the Tumor Microenvironment and Its Dynamic Events -- Chapter 5. The Tumor Microenvironment — an Introduction for the Development of Microfluidic Devices -- Chapter 6. Biomaterials for Mimicking and Modelling Tumor Micro-environment -- Chapter 7. Advancing Tumor Microenvironment Research by Combining Organs-on-chips and Biosensors -- Chapter 8. Microfluidic-driven Biofabrication and the Engineering of Cancer-like Microenvironments -- Chapter 9. Advances in 3d Vascularized Tumor-on-a-chip Technology -- Part 3. Cancer Detection and Diagnosis -- Chapter 10. Biosensors Advances: Contributions to Cancer Diagnostics and Treatment -- Chapter 11. Flexible Sensing Systems for Cancer Diagnostics -- Chapter 12. Coupling Micro-physiological Systems and Biosensors for Improving Cancer Biomarkers Detection -- Chapter 13. Microfluidic Biosensor-based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis -- Chapter 14. Liquid Biopsies: Flowing Biomarkers -- Chapter 15. From Exosomes to Circulating Tumor Cells: Using Microfludics to Detect High Predictive Cancer Biomarkers -- Chapter 16. Microfluidics for the Isolation and Detection of Circulating Tumor Cells -- Chapter 17. Evolution in Automatized Detection of Cancer Cells: Advances in Magnetic Microcytometers -- Chapter 18. Droplet-based Microfluidic Chip Design, Fabrication and Use for Ultrahigh-throughput DNA Analysis and Quantification -- Chapter 19. Emerging Microfluidic and Biosensor Technologies for Improved Cancer Theranostics -- Part 4. Clinical Applications: Towards Personalized Medicine -- Chapter 20. Microfluidics for Cancer Biomarker Discovery, Research and Clinical Application -- Chapter 21. Methods for the Detection of Circulating Biomarkers in Cancer Patients -- Chapter 22. Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine.
    Abstract: This book offers a comprehensive overview of the development and application of microfluidics and biosensors in cancer research, in particular, their applications in cancer modeling and theranostics. Over the last decades, considerable effort has been made to develop new technologies to improve the diagnosis and treatment of cancer. Microfluidics has proven to be a powerful tool for manipulating biological fluids with high precision and efficiency and has already been adopted by the pharmaceutical and biotechnology industries. With recent technological advances, particularly biosensors, microfluidic devices have increased their usefulness and importance in oncology and cancer research. The aim of this book is to bring together in a single volume all the knowledge and expertise required for the development and application of microfluidic systems and biosensors in cancer modeling and theranostics. It begins with a detailed introduction to the fundamental aspects of tumor biology, cancer biomarkers, biosensors and microfluidics. With this knowledge in mind, the following sections highlight important advances in developing and applying biosensors and microfluidic devices in cancer research at universities and in the industry. Strategies for identifying and evaluating potent disease biomarkers and developing biosensors and microfluidic devices for their detection are discussed in detail. Finally, the transfer of these technologies into the clinical environment for the diagnosis and treatment of cancer patients will be highlighted. By combining the recent advances made in the development and application of microfluidics and biosensors in cancer research in academia and clinics, this book will be useful literature for readers from a variety of backgrounds. It offers new visions of how this technology can influence daily life in hospitals and companies, improving research methodologies and the prognosis of cancer patients.
    Type of Medium: Online Resource
    Pages: XIX, 590 p. 100 illus., 99 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031040399
    Series Statement: Advances in Experimental Medicine and Biology, 1379
    URL: https://doi.org/10.1007/978-3-031-04039-9
    DOI: 10.1007/978-3-031-04039-9
    DDC: 571.978
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    The Heterogeneity of Cancer Metabolism (2021)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Metabolism. ; Cancer Treatment. ; Cancer Metabolism. ; Cancer Therapy. ; Cancer Biology.
    Description / Table of Contents: Part I. Basic Metabolism of Cancer Cells -- Glucose Metabolism in Cancer the Warburg effect and Beyond -- Glutamine Metabolism in Cancer -- The Heterogeneity of Lipid Metabolism in Cancer -- Part II. Heterogeneity of Cancer Metabolism -- The Multifaceted Glioblastoma: from Genomic Alterations to Metabolic Adaptions -- The Intricate Metabolism of Pancreatic Cancers -- The heterogeneity of breast cancer metabolism for therapy -- Non-Hodgkin Lymphoma Metabolism -- The Heterogeneity Metabolism of Renal Cell Carcinomas -- The Heterogeneity Metabolism of Liver Cancer -- Different Tumor Microenvironments Lead to Different Metabolic Phenotypes -- The Intratumoral Heterogeneity of Cancer Metabolism -- Cancer Stem Cells Metabolism -- Metabolism of Immune cells in the Tumor Microenvironment -- Part III. Relationship between Cancer Cells and Cancer-Associated Fibroblasts -- Metabolic Relationship between Cancer-Associated Fibroblasts and Cancer Cells -- Targeting Metabolic Cross Talk between Cancer Cells and Cancer-Associated Fibroblasts -- Part IV. The metabolic interplay between cancer and other diseases -- Diabetes and Cancer: the Epidemiological and Metabolic Associations -- Bridging the Metabolic Parallels between Neurological Diseases and Cancer -- Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy -- Index.
    Abstract: This open access volume will introduce recent discoveries in the field of cancer metabolism since the publication of the first edition in 2018, providing readers with an up-to-date understanding of developments in the field. Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, the authors delve into the complexity and diversity of cancer metabolism and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies for cancer treatment. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer treatment. This book has four major parts. Part one will cover the basic metabolism of cancer cells, followed by a discussion of the heterogeneity of cancer metabolism in part two. Part three addresses the relationship between cancer cells and cancer-associated fibroblasts, and the new part four will explore the metabolic interplay between cancer and other diseases. This new section makes the book unique from other texts currently available on the market. The second edition will be useful for cancer metabolism researchers, cancer biologists, epidemiologists, physicians, health care professionals in related disciplines, policymakers, marketing and economic strategists, etc. It may also be used in courses such as intro to cancer metabolism, cancer biology, and related biochemistry courses for undergraduate and graduate students. .
    Type of Medium: Online Resource
    Pages: XXIII, 271 p. 55 illus., 54 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030657680
    Series Statement: Advances in Experimental Medicine and Biology, 1311
    URL: https://doi.org/10.1007/978-3-030-65768-0
    DOI: 10.1007/978-3-030-65768-0
    DDC: 571.978
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    Tumor Microenvironment : The Role of Interleukins – Part B (2021)
    Cham :Springer International Publishing :
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    Keywords: Cancer. ; Tumors Immunological aspects. ; Cytology. ; Internal medicine. ; Cancer Microenvironment. ; Tumour Immunology. ; Cancer Biology. ; Cell Biology. ; Internal Medicine.
    Description / Table of Contents: Interleukin-6 function and targeting in prostate cancer -- IL-7 signaling in the tumor microenvironment -- IL-10 Signaling in the Tumor Microenvironment of Epithelial Ovarian Cancer -- Targeted delivery of IL-12 adjuvants immunotherapy by oncolytic viruses -- IL-22 signaling in the tumor microenvironment -- IL-23 and the Tumor Microenvironment -- Interleukin (IL)-24: Reconfiguring the tumor microenvironment for eliciting antitumor response -- Interleukin-31, a potent pruritus-inducing cytokine and its role in inflammatory disease and in the tumor microenvironment -- Index.
    Abstract: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-6, IL-7, IL-10, IL-12, IL-22, IL-23, and IL-24 signaling. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins – Part Bupdates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
    Type of Medium: Online Resource
    Pages: XII, 134 p. 23 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030556174
    Series Statement: Advances in Experimental Medicine and Biology, 1290
    URL: https://doi.org/10.1007/978-3-030-55617-4
    DOI: 10.1007/978-3-030-55617-4
    DDC: 571.978
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    Bone Marrow Niche : Microenvironments Critical for Immune Cell Development (2021)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Stem cells. ; Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Stem Cell Biology. ; Biomedical Research. ; Human Physiology.
    Description / Table of Contents: Preface -- Skeletal stem cells as the developmental origin of cellular niches for hematopoietic stem and progenitor cells -- Cellular niches for hematopoietic stem cells and lympho-hematopoiesis in bone marrow during homeostasis and blood cancers -- Remodeling of the bone marrow stromal microenvironment during pathogenic infections -- The Roles of IL-7 and IL-15 in Niches for Lymphocyte Progenitors and Immune Cells in Lymphoid Organs -- Lymph node stromal cells: diverse meshwork structures weave functionally subdivided niches -- Immune Niche within the Peritoneal Cavity.
    Abstract: This volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.
    Type of Medium: Online Resource
    Pages: VII, 134 p. 19 illus., 17 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030860165
    Series Statement: Current Topics in Microbiology and Immunology, 434
    URL: https://doi.org/10.1007/978-3-030-86016-5
    DOI: 10.1007/978-3-030-86016-5
    DDC: 571.96
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    Perinatal Inflammation and Adult Psychopathology : From Preclinical Models to Humans (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Psychiatry. ; Gynecology . ; Diseases. ; Neurosciences. ; Psychobiology. ; Human behavior. ; Immunology. ; Psychiatry. ; Gynecology. ; Diseases. ; Neuroscience. ; Behavioral Neuroscience.
    Description / Table of Contents: Chapter 1. Perinatal psychiatry: ready for prime time?- Chapter 2. Pregnancy, stress response and neuroinflammation: effects on offspring and risk for psychiatric disorders -- Chapter 3. Epigenetic modifications of early life stress and adult life psychopathology -- Chapter 4. Perinatal HPA programming and adult psychopatholgoy -- Chapter 5. Intergeneration transmission of depression: focus on inflammation -- Chapter 6. Neonatal bacterial meningitis: mechanisms and implications for adult life psychopathology -- Chapter 7. Toxoplasmosis as risk factor for severe psychiatric disorders: clinical and pre-clinical evidence -- Chapter 8. A critical appraisal on the epidemiological evidence linking perinatal inflammation and risk of psychosis -- Chapter 9. Maternal Immune Activation as a Risk Factor for Schizophrenia: Evidence from Preclinical and Clinical Studies -- Chapter 10. Influences of sex and age in MIA-induced behavioral and neurobiological alterations -- Chapter 11. MIA and autism -- Chapter 12. Zika virus infection and neuropsychiatric complications -- Chapter 13. Placenta immunology: impact on fetus development -- Chapter 14. Placenta and cord blood as source of immune markers of offspring development and psychopathology -- Chapter 15. Cytokine model of cognitive function.
    Abstract: Perinatal psychiatry is an emerging field that investigates the role of perinatal events – for example pregnancy complications and infections – in the development of neuropsychiatric conditions, such as schizophrenia and mood disorders. Among the implicated pathological mechanisms, perinatal-induced inflammation seems to play a major role and is being considered as a potential target for therapeutic intervention. Bringing together various approaches in the field (preclinical and clinical, epidemiological, immunological and genetic methods), the book discusses the available evidence, the putative mechanisms and the challenges ahead.
    Type of Medium: Online Resource
    Pages: XI, 268 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030393359
    Series Statement: Progress in Inflammation Research, 84
    URL: https://doi.org/10.1007/978-3-030-39335-9
    DOI: 10.1007/978-3-030-39335-9
    DDC: 571.96
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    Sex and Gender Differences in Infection and Treatments for Infectious Diseases (2023)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Internal medicine. ; Microbiology. ; Pharmacology. ; Immunology. ; Internal Medicine. ; Microbiology. ; Pharmacology.
    Description / Table of Contents: Genetics of sex differences in immunity -- The influence of sex hormones and X chromosome in immune responses -- Sex Differences in HIV Infection -- Chapter 6: Effects of Biological Sex and Pregnancy on SARS-CoV-2 Pathogenesis and Vaccine Outcomes -- Biological sex and pregnancy affect influenza pathogenesis and vaccination -- Sex and gender differences in tuberculosis pathogenesis and treatment outcomes -- Sex-Linked Differences in Malaria Risk Across the Lifespan -- Sex Difference in Amebiasis -- Sex Differential and Non-Specific Effects of Vaccines Over the Life Course -- Immunology of pregnancy and systemic consequences.
    Abstract: This fully revised and significantly expanded second edition examines sex and gender differences in the immune system's response to bacterial, viral, and parasitic infections. The volume discusses both common and distinct molecular mechanisms that mediate these differences and illustrates how responses to vaccines may differ between the sexes and in pregnant individuals. Special emphasis is placed on the interplay between hormones and the immune system in the pathogenesis of HIV, SARS-CoV-2, influenza, malaria, tuberculosis, and amebiasis. This second edition includes completely rewritten chapters as well as all new contents. This book is intended for researchers in academia and industry as well as clinicians in the fields of microbiology, immunology, and pharmacology. By expanding knowledge in sex and gender medicine as a basis for developing personalized treatment strategies, the book contributes to UN Sustainable Development Goals 3 (health and well-being) and 5 (gender equality).
    Type of Medium: Online Resource
    Pages: VI, 280 p. 14 illus., 13 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031351396
    Series Statement: Current Topics in Microbiology and Immunology, 441
    URL: https://doi.org/10.1007/978-3-031-35139-6
    DOI: 10.1007/978-3-031-35139-6
    DDC: 571.96
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    PI3K and AKT Isoforms in Immunity : Mechanisms and Therapeutic Opportunities (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Immune system. ; Cellular signal transduction. ; Cytology. ; Autoimmunity. ; Immunospecificity. ; Immunology. ; Immune Cell Signalling. ; Cell Biology. ; Autoimmunity. ; Adaptive Immunity.
    Description / Table of Contents: Class I PI3K biology -- Class II PI3K biology -- Class III PI3K biology -- PTEN in immunity -- PHLPP Signaling in Immune Cells -- PHLPP Signaling in Immune Cells -- PI3K isoforms in cell signalling and innate immune cell responses -- AKT isoforms in macrophage activation, polarization and survival -- Control of CD4+ T cell Differentiation and Function by PI3K isoforms. -- PI3K isoforms in CD8+ T cell development and function -- PI3K isoforms in B cells -- PI3K isoform signalling in platelets -- PI3K isoforms in vascular biology, a focus on the vascular system-immune response connection -- PI3K and AKT at the Interface of Signaling and Metabolism -- The Role of PI3K Isoforms in Autoimmune Disease -- AKT Isoforms in the Immune Response in Cancer -- PI3K isoform immunotherapy for solid tumours -- PI3K targeting in non-solid cancer -- AKT isoforms as a target in cancer and immunotherapy -- Developing PI3K Inhibitors for Respiratory Diseases.
    Abstract: This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
    Type of Medium: Online Resource
    Pages: VII, 466 p. 42 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031065668
    Series Statement: Current Topics in Microbiology and Immunology, 436
    URL: https://doi.org/10.1007/978-3-031-06566-8
    DOI: 10.1007/978-3-031-06566-8
    DDC: 571.96
    Language: English
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    Three Dimensional Human Organotypic Models for Biomedical Research (2021)
    Cham :Springer International Publishing :
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    Keywords: Immunology. ; Cancer. ; Regenerative medicine. ; Stem cells. ; Cytology Technique. ; Immunology. ; Cancer Biology. ; Regenerative Medicine and Tissue Engineering. ; Stem Cell Biology. ; Cytological Techniques.
    Description / Table of Contents: Introduction: Rationale of using skin models in research -- Skin anatomy (human and animals for experimental research) -- In vivo skin models -- In vitro human skin models (Skin equivalents vs skin explants) -- Human skin models for studying cutaneous infections -- Skin animal models for pharmacological research -- Human skin models for pharmacological research -- Human skin models for allergological research -- Human skin models for cancer research -- Human skin models for vaccine research.
    Abstract: This edited volume discusses the application of very diverse human organotypic models in major areas of biomedical research. The authors lay a main focus on infectious diseases, cancer, allergies, as well as drug/vaccine discovery and toxicology studies. Representing a valid alternative to laboratory animals, these models are relevant for most areas of translational research. As the contemporary research shows, many human tissues can today be cultivated in vitro and used for several research objectives. This book provides an unprecedented overview of recent developments in an exciting field of research methodology. It is a reference guide for scientists in both academia and industry. Readers can update their knowledge and get hands-on recommendations on how to set up an organotypic model in their lab. Chapters 'Progress on Reconstructed Human Skin Models for Allergy Research and Identifying Contact Sensitizers' and 'Human Organotypic Models for Anti-infective Research' of this book are available open access under a CC BY 4.0 license at link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 265 p. 22 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030624521
    Series Statement: Current Topics in Microbiology and Immunology, 430
    URL: https://doi.org/10.1007/978-3-030-62452-1
    DOI: 10.1007/978-3-030-62452-1
    DDC: 571.96
    Language: English
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    The Marathon of the Messenger : A History of Messenger RNA Vaccines (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Biology Technique. ; Biotechnology. ; Molecular biology. ; Industrial engineering. ; Production engineering. ; Immunology. ; Biological Techniques. ; Biotechnology. ; Molecular Biology. ; Industrial and Production Engineering.
    Description / Table of Contents: Chapter 1. Introduction: The Marathon of the Messenger RNA -- Part I. Messenger RNA, an essential role and challenge -- Chapter 2. A short history of vaccination -- Chapter 3. From DNA to RNA -- Chapter 4. Messenger RNA (mRNA): from transcription to protein translation -- Chapter 5. The mechanism of viral infection -- Chapter 6. The immune response -- Part II. From preliminary studies to clinical trials -- Chapter 7. Promising studies in the 1990s -- Chapter 8. The use of mRNA - the initial technical obstacles -- Chapter 9. The birth of CureVac: the era of the pioneers -- Chapter 10. Solutions for mRNA optimization -- Chapter 11. Modified and unmodified mRNA: for what purpose? -- Chapter 12. Experiments and clinical trials conducted: the power of therapeutic mRNA -- Chapter 13. Experiments and clinical trials against infectious diseases -- Chapter 14. Experiments and clinical trials against cancer -- Chapter 15. Experiments and clinical trials carried out in other therapeutic fields -- Chapter 16. Modified mRNA versus unmodified mRNA: not just a scientific issue -- Part III. The triumph of messenger RNA -- Chapter 17. A very progressive diffusion in scientific circles -- Chapter 18. The development of future biotechs in the 2010s -- Chapter 19. The importance of intellectual property and patents -- Chapter 20. 2020: the triumph of anti-Covid mRNA vaccines -- Chapter 21. mRNA, a technology of the future.
    Abstract: The Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other – especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to this day. In the face of a prevailing single-mindedness, these researchers pushed through a new therapeutic concept and defined the biotechnological keys that would open the way to the production of therapeutic messenger RNA in the fight against cancer and viral infections. Written for a broad audience and accompanied by humorous cartoons, this book will appeal to anyone looking for scientific and historical answers about mRNA vaccines. Readers will discover not only the technical and scientific knowledge of how these vaccines work, but also the economic levers that were necessary to create this technology. This book has been written in collaboration with Dr. Steve Pascolo, former director of CureVac, and the RNA messenger expert Professor Chantal Pichon. It also features a preface by Dr. Pierre Meulien, former director of the European Union public-private partnership Innovative Medicines Initiative (IMI). This book is a translation of an original French edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.
    Type of Medium: Online Resource
    Pages: XXIII, 202 p. 44 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031393006
    URL: https://doi.org/10.1007/978-3-031-39300-6
    DOI: 10.1007/978-3-031-39300-6
    DDC: 571.96
    Language: English
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    Alternate Programmed Cell Death Signaling in Antiviral Host Defense (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Immunology. ; Medical microbiology. ; Virology. ; Immunology. ; Medical Microbiology. ; Virology.
    Description / Table of Contents: Programmed Necrosis in Host Defense -- ZBP1/DAI-dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis -- Pyroptosis in Antiviral Immunity -- Manipulation of Host Cell Death Pathways by Herpes Simplex Virus -- Subversion of Programed Cell Death by Poxviruses -- Cell Killing by Reovirus: Mechanisms and Consequences -- Outcomes of RIP kinase signaling during neuroinvasive viral infection.
    Abstract: This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system. Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus. Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV) where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3). This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology.
    Type of Medium: Online Resource
    Pages: V, 174 p. 19 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031452789
    Series Statement: Current Topics in Microbiology and Immunology, 442
    URL: https://doi.org/10.1007/978-3-031-45278-9
    DOI: 10.1007/978-3-031-45278-9
    DDC: 571.96
    Language: English
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