ALBERT

Description / Table of Contents: Chapter 1 Introduction -- Chapter 2 Unconventional functions of transcription factors -- GAGA transcription factor -- Heterochromatin protein 1 -- Retinoblastoma protein -- STAT -- ATF-2 -- NF-kB -- Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer -- STAT and HP1 promote longevity -- STAT and HP1 protect against DNA damage -- Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model -- Chapter 4 The possible biological significance of transcription factors’ unconventional functions -- The epigenome -- Processes in the cell nucleus -- Future Work.

Description / Table of Contents: Past, present and future perspectives of renin angiotensin system -- Biochemical pathways of renin angiotensin system -- Structure-function relationships of angiotensin II receptors -- Signal transduction mechanism of angiotensin II -- Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection -- Angiotensin II and the pathogenesis of hypertension -- Signaling transduction of angiotensin II in hypertension -- Role of angiotensin II type 1 receptors in vascular remodeling in hypertension -- Molecular and cellular mechanisms of renin-angiotensin system in hypertension -- Tissue renin-angiotensin system and risks in hypertension -- Oxidative stress and angiotensin II-induced hypertension -- Angiotensin II: inflammatory system disorder and hypertension -- Therapeutic approaches for angiotensin receptor blockers in hypertension -- Renin-angiotensin systems: A pivotal role in the development of atherosclerosis -- Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis -- Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability -- Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis -- The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation -- Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis -- Effects of angiotensin-converting enzyme and receptors in atherosclerosis -- Effects of angiotensin II on cardiac arrhythmia and signal transduction -- Angiotensin II induced oxidative stress contribute to ventricular arrhythmias -- Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias -- ACE inhibitor and ventricular arrhythmia in ischemic heart disease -- The renin-angiotensin system modulators and cardiac arrhythmias -- Angiotensin receptor blockers in the treatment of arrhythmias -- Angiotensin II induced cardiac hypertrophy and heart failure -- Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure -- Renin-angiotensin system: Molecular and cellular mechanisms in heart failure -- Role of angiotensin II receptor mRNA expression in heart failure -- Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure -- Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure -- Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure -- Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update -- Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure.

Description / Table of Contents: Chapter 1. Pandemic-Era Digital Education: Insights from an Undergraduate Medical Programme -- Chapter 2. Use of Lt Systems in Large Class Lab Delivery -- Chapter 3. COVID-19 Adaptations for Biomedical Teaching and Assessment Within the Undergraduate Dental Curriculum -- Chapter 4. One Size Does Not Fit All in Remote Anatomy Teaching -- Chapter 5. From Lecture Halls to Zoom Links: How Can Educational Theory Help Us to Deliver Effective and Engaging Teaching in an Online Environment? -- Chapter 6. Collaborative, Two-Directional Live Streaming to Deliver Hands-on Dissection Experience during the COVID-19 Lockdown -- Chapter 7. Livestreaming Can Augment the Observation of Veterinary Post-mortem Examinations -- Chapter 8. Virtual Reality for Anatomy and Surgical Teaching -- Chapter 9. Can Synchronous Online Near-Peer Teaching Offer the Same Benefits as the Face-to-Face Version When Used in Clinical Neuroanatomy Education? -- Chapter 10. COVID-19 Adaptations with Virtual Microscopy -- Chapter 11. The Challenges of Visualisation During Delivery and Assessment of Clinical Teaching Under COVID-19: A Reflective Account of Problem Solving -- Chapter 12. Not for Room 101.

Description / Table of Contents: Introduction (MCG and FN) -- Updates on ATMP regulations from EU: experience with PRIME procedure and list of approved ATMP -- EU portal for clinical trials application -- European Pharmacopoeia texts on gene therapy medicinal products -- Updates on ATMP regulations from UK after Brexit and list of approved ATMP -- Updates on ATMP regulations from Switzerland and list of approved ATMP -- Updates on ATMP regulations from US FDA: experience with breakthrough/accelerated procedures and list of approved ATMP -- Updates on ATMP regulations from Canada and list of approved ATMP -- Updates on ATMP regulations from Brasil and list of approved ATMP -- Updates on ATMP regulations from Singapore and list of approved ATMP -- Updates on ATMP regulations from Japan: experience with new law and list of approved ATMP -- Updates on ATMP regulations from South Korea and list of approved ATMP -- Updates on ATMP regulations from Taiwan and list of approved ATMP -- Updates on ATMP regulations from Thailand and list of approved ATMP -- ATMP regulations in China and list of approved ATMP -- ATMP regulations in Australia and list of approved ATMP -- ATMP regulations in India and list of approved ATMP -- International harmonization programs. .

Description / Table of Contents: The Art of Cell Therapy -- Scope and Applicability of Autologous Cell Therapies -- Scale and Accessibility of Allogeneic Cell Therapies -- Acellular Stem Cell Products. Potency Assays: The Buggy Boo of Stem Cell Therapy -- Potency Assay Development: A Keystone for Clinical Use -- Quantifying Critical Quality Attributes -- Advanced Technologies for Potency Assay Measurement -- Potency Quality by Design: Tailoring for Specific Therapy -- Contract Research Organizations Expediting Therapeutic Availability -- Regulatory Authority Perspectives for Potency Release Criteria -- Illustrative Potency Assay Examples from Approved Therapies -- The Integrity of Potency Assays and Safe Intervention -- The Evolving Landscape of Potency Assays.

Description / Table of Contents: Chapter 1. The COVID-19 Pandemic: SARS-CoV-2 Structure, Infection, Transmission, Symptomology and Variants of Concern -- Chapter 2. Long-term Vaccination and Treatment Strategies for COVID-19 Disease and Future Coronavirus Pandemics -- Chapter 3. Consequences of the Lockdown - Domestic Violence during the COVID-19 Pandemic -- Chapter 4. Psychological distress impact of Coronavirus disease (COVID-19) outbreak on three continents: A systematic review and meta-analysis -- Chapter 5. A Molecular Biomarker-based Triage Approach for Targeted Treatment of Post-COVID-19 Syndrome Patients with Persistent Neurological or Neuropsychiatric Symptoms -- Chapter 6. Genetic Associations with Coronavirus Susceptibility and Disease Severity -- Chapter 7. COVID Diagnostics: from Molecules to Omics -- Chapter 8. Assessing Biomarkers in Viral Infection -- Chapter 9. Proteomic Investigation of COVID-19 Severity During the Tsunamis Second Wave in Mumbai -- Chapter 10. NMR-Metabolomics in COVID-19 Research -- Chapter 11. Potential Biomarkers of Mitochondrial Dysfunction Associated with COVID-19 Infection -- Chapter 12. Red Cell Distribution Width as a Prognostic Indicator for Mortality and ICU Admission in Patients with COVID-19 -- Chapter 13. Predicting the COVID-19 Patients Status using Chest CT Scan Findings: A Risk Assessment Model Based on Decision Tree Analysis -- Chapter 14. Inferring Recombination Events in SARS-CoV-2 Variants In Silico -- Chapter 15. Amplicon-based Nanopore Sequencing of Patients Infected by the SARS-CoV-2 Omicron (B.1.1.529) Variant in India -- Chapter 16. Perspectives on Rapid Antigen Tests for Downstream Validation and Development of Theranostics -- Chapter 17. Machine Learning and COVID-19: Lessons from SARS-CoV-2 -- Chapter 18. The Relationship between Psoriasis, COVID-19 Infection and Vaccination during Treatment of Patients -- Chapter 19. Immunogenicity of Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV; Sinopharm) and Short-term Clinical Outcomes in Vaccinated Solid Organ Transplant Recipients: A Prospective Cohort Study -- Chapter 20. Spices and Biomarkers of COVID-19: A Mechanistic and Therapeutic Perspective -- Chapter 21. Antiviral Mechanisms of Curcumin and its Derivatives in Prevention and Treatment of COVID-19: A review -- Chapter 22. Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial -- Chapter 23. Chronobiological Efficacy of Combined Therapy of Pelargonium Sidoides and Melatonin in Acute and Persistent Cases of COVID-19: A Hypothetical Approach -- Chapter 24. The Potential Effect of Royal Jelly on Biomarkers Related to COVID-19 Infection and Severe Progression -- Chapter 25. Statins: Beneficial Effects in Treatment of COVID-19 -- Chapter 26. Multiplex Immunoassay Approaches Using Luminex® xMAP® Technology for the Study of COVID-19 Disease -- Chapter 27. Rapid Detection of SARS-CoV-2 Variants of Concern by Genomic Surveillance Techniques.

Description / Table of Contents: Brain Tissue Oxygen and BOLD fMRI Under Different Levels Of Neuronal Activity -- Cerebral Microcirculation and Oxygenation Modulation by Transcranial Alternating Current Stimulation in Awake and Anesthetized Mice -- The Effect of Hypercapnia on Cortical Metabolic Rate and Mitochondrial Redox Status -- Relationship Between Left-Right Dominancy of Prefrontal Cortex Activity and Heart Rate During Rest and Task Periods: An fNIRS Study -- Relationship Between Cognitive Function, Oral Conditions and Systemic Metabolic Function in the Elderly -- Pro-survival Phenotype of HIF-1α: Neuroprotection through Inflammatory Mechanisms -- Infradian Rhythms in Cerebrovascular Oxygenation and Blood Volume in Humans at Rest: A 5-year Study -- Mechanisms of Photostimulation of Brain’s Waste Disposal System: the Role of Singlet Oxygen -- Changes of Arterial and Venous Cerebral Blood Flow Correlation in Moderate-to-Severe Traumatic Brain Injury: A CT Perfusion Study -- Cerebral Net Water Uptake in Posttraumatic Cerebral Ischemia -- Brainstem Damage Underlies Changes in Hypoxic Ventilatory Response following Cardiac Arrest and Resuscitation in Rats -- Differences Between Good, Moderate and Poor Performers of a Verbal Fluency Task under Blue Light Exposure: An SPA-fNIRS Study -- Sex-specific and Dose-dependent Effects of Drag-Reducing Polymers on Microcirculation and Tissue Oxygenation in Rats after Traumatic Brain Injury -- Accuracy of Tissue Oxygen Saturation Measurements of a Textile-based NIRS Sensor -- Understanding the Role of Caveolae in Oxygen Buffering: The Effect of Membrane Curvature -- The Significance of Lipids for the Absorption and Release of Oxygen in Biological Organisms -- How Skin Color Depends on Tissue Oxygenation -- Tissue Concentration Analysis of Sulfur, Calcium and Oxygen in novel Skin Primo Nodes After Acupuncture -- Primo Vessels Inside Lymphatic Vessels are Absent in an ALS Mouse Model -- The Impact of Heterogeneous Cell Density in Hypoxic Tumors Treated with Radiotherapy -- A Critical Analysis of Possible Mechanisms for the Oxygen Effect in Radiation Therapy with FLASH -- Hyperhydration of Cancers: A Characteristic Biophysical Trait Strongly Increasing O2, CO2, Glucose and Lactate Diffusivities, and Improving Thermophysical Properties of Solid Malignancies -- No Difference in Muscle Basal Oxygenation in a Bedridden Population pre and Post Rehabilitation -- Relationship between Muscle Deoxygenation and Cardiac Output in Subjects without Attenuation of Deoxygenation Hemoglobin Concentration near the end of Ramp Cycling Exercise: A Longitudinal Study -- Image Reconstruction Using Deep Learning for Near-Infrared Optical Tomography: Generalization Assessment -- Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy -- Time Domain Near-Infrared Optical Tomography Utilizing Full Temporal Data: A Simulation Study -- BIAN: A Multilayer Microfluidic-Based Tissue-Mimicking Phantom for Near-Infrared Imaging -- Do Vascular and Extracellular Measurements Consistently Reflect Intracellular pO2? Observation of Tissue Oxygenation Changes using Remote Photoplesysmography with a Smartphone -- Neurovascular, Metabolic, and Glymphatic Dynamics of the Brain Measured with fNIRS -- Imaging Cerebral Blood Vessels Using Near-Infrared Optical Tomography: A Simulation Study -- Reduced Cerebrovascular Oxygenation in Individuals with Post-Acute COVID-19 Syndrome (PACS) (“Long COVID”) -- Insufficient Oxygen Supplementation During Cardiopulmonary Resuscitation Leads to Unfavorable Biological Response While Hyperoxygenation Contributes to Metabolic Compensation -- Block of the Angiotensin Pathways Affects Flow-Volume Spirometry in Patients With SARS-CoV-2 Infection -- A Prospective Observational Pilot Study on the Effects of the Activity-based Stress Release Program on the Mental State and Autonomic Nervous System in Psychiatric patients. .

Description / Table of Contents: PART I: Fundamental Aspects -- Chapter 1. Definition of Tremor -- Chapter 2. Membrane Mechanisms of Tremor -- Chapter 3 Advances in the Genetics of Human Tremor -- Chapter 4. Two origins of tremors related to the Guillain-Mollaret triangle: the forward model-related tremor and the inferior olive oscillation-related tremor -- PART II:Tremor in Clinical Practice -- Chapter 5. Physiologic Tremor -- Chapter 6. Rest Tremor -- Chapter 7. Postural Tremors -- Chapter 8. Isometric Tremor -- Chapter 9. Essential Tremor and Other Forms of Kinetic Tremor -- Chapter 10. Cerebellar lesions and tremor -- Chapter 11. Orthostatic Tremor -- Chapter 12. Posttraumatic Tremor and Other Posttraumatic Movement Disorders -- Chapter 13 Tremor in Childhood -- Chapter 14. Metabolic Causes of Tremor -- Chapter 15. Drug-Induced Tremor -- Chapter 16. Tremor: The Clinical Approach to Reach the Diagnosis -- PART III: Assessment of tremor -- Chapter 17. Signal Processing -- Chapter 18. Diffusion imaging in Tremor -- Chapter 19. The role of the noradrenergic system in tremor pathogenesis -- Chapter 20. Metabolic Networks in Parkinson’s Disease -- PART IV: Therapies -- Chapter 21. Deep brain stimulation for tremor -- Chapter 22 Mechatronic Devices for Upper Limb Tremor.

Description / Table of Contents: Part 1: Setting the scene -- Chapter 1: Life after Academia: Launching your Pharma/Biotech Career -- Chapter 2: Competences for Pharmacists -- Chapter 3: Job and Career Opportunities in the Pharmaceutical Industry: An Overview -- Part 2: Opportunities along the drug/product life cycle -- Chapter 4: Career Opportunities in Toxicology -- Chapter 5: Job Possibilities in Clinical Research -- Chapter 6: How to Get and Develop a Career in a Market Access Role in the Medical Devices Industry -- Chapter 7: Job Opportunities in Pharmaceutical Marketing -- Chapter 8: Working in Medical Affairs and Clinical Operations: Life-Changing Careers -- Chapter 9: The Role of Medical Science Liaison -- Chapter 10: Career Development for Physicians in the Biopharmaceutical Industry -- Part 3: Opportunities in Supportive Functions -- Chapter 11: Job and Career Opportunities in Regulatory Affairs/Science -- Chapter 12: Job Opportunities in Clinical Research Quality Assurance -- Chapter 13: Job Opportunities in Quality Assurance Related to Manufacturing of Medicinal Products -- Part 4: Other Opportunities in the Pharmaceutical and Biomedical Sector -- Chapter 14: Careers Perspective in a Science and Technology Park -- Chapter 15: To be or not to be: Entrepreneurship and Enterprise Creation as a Way to Innovate in Life Sciences -- Chapter 16: How to Become a Successful Hospital and Community Pharmacist -- Part 5: Practical tips and tricks -- Chapter 17: A Successful Career in the Life Sciences Industry: How to Write your Strongest Resumé and Ace that Interview -- Chapter 18: Skill Building for Career Advancement: Public Speaking and Networking -- Chapter 19: Training Opportunities for a Career in the Pharmaceutical and Biomedical Industry/Sector.

Description / Table of Contents: 1. Introduction on Tuberculosis: Integrated Studies for a Complex Disease -- 2. Global Tuberculosis Epidemiology -- 3. Heterogeneity in Tuberculosis -- 4. The Unequivocal Relationship between Tuberculosis and Tobacco: Integration of Two Maladies -- 5. Relationship between Pre-existing Cancer and Tuberculosis -- 6. Laboratory Diagnosis of Tuberculosis -- 7. The Role of Diagnostic Microdevices in the Fight Against Tuberculosis -- 8. Immunodiagnostics of Tuberculosis: Recent Discoveries -- 9. Role of Bronchoscopy in Diagnostics and Treatment of Tuberculosis -- 10. Diagnosis of Childhood Tuberculosis in Low- and Middle-income Countries -- 11. Pediatric Tuberculosis: Current Evidence for Laboratory Diagnosis -- 12. A Multidisciplinary Approach Towards Finding and Treating All Tuberculosis Patients -- 13. Chemotherapy for Drug-Susceptible Tuberculosis -- 14. The Pharmacokinetic and Pharmacodynamic Properties of Antitubercular Medications -- 15. Immune Approaches In Tuberculosis Treatment -- 16. Inhalation Therapy in Pulmonary Tuberculosis -- 17. Role of Micronutrients in Tuberculosis Management -- 18. Drug Resistance in Tuberculosis: Mechanisms, Diagnosis, New Responses, and the Need for An Integrated Approach -- 19. Resistance in Tuberculosis: Molecular Mechanisms and Modulation -- 20. Personalized Tuberculosis Care for Drug-Resistant Tuberculosis -- 21. Important Targets and Inhibitors of Mycobacterium Tuberculosis -- 22. P-type ATPases: A Relevant Component in Mycobacterium tuberculosis Viability -- 23. The Challenges of Antitubercular Drug Discovery -- 24. Exploring Decaprenylphosphoryl-β-D-ribose 2’-Epimerase 1 (DprE1): A Target for Anti-Tubercular Drugs -- 25. Energy Pathways in Mycobacterium Tuberculosis -- 26. Drug Discovery for Non-Tuberculous Mycobacteria: Recent Updates -- 27. Challenges for Contact Tracing and Tuberculosis Preventive Therapy Scale-up -- 28. Exploring Problematizations Underlying Tuberculosis Control Strategies: A Cross-Country Analysis of India and Kenya -- 29. Challenges in Prevention and Management of Tuberculosis -- 30. Tuberculosis in Contacts and Healthcare Workers -- 31. Tuberculosis Among People Who Use Drugs: Multilevel Considerations for Prevention, Diagnosis, and Treatment -- 32. Anti-Tumor Necrosis Factor-α Antagonists and Tuberculosis -- 33. Breast Tuberculosis -- 34. Central Nervous System Tuberculosis: Pathogenesis, Diagnosis, and Management -- 35. Pleural Tuberculosis -- 36. Ocular Tuberculosis -- 37. Ocular Tuberculosis: Biomarkers for Risk Stratification -- 38. Bone and Joint Tuberculosis -- 39. Abdominal Tuberculosis: Pathogenesis, Clinical Features, and Diagnosis -- 40. Bovine Tuberculosis at The Interface of Cattle, Wildlife, and Humans -- 41. Evolution and Molecular Characteristics of Mycobacterium Tuberculosis and Mycobacterium Bovis -- 42. Animal Tuberculosis: Gross Lesions and Anatomopathological Diagnosis -- 43. Estimation of Microbial Mutation Rates in Tuberculosis Research -- 44. The Role of Epigenetics in the Development of Anti-Tuberculosis Drug Resistance -- 45. Multiomics Integration of Tuberculosis Pathogenesis -- 46. Lung Microbiome in Tuberculosis -- 47. The Correlation of Microbiota and Host Epigenome in Tuberculosis -- 48. The Pathogenesis and Progression of Sarcoidosis from The Standpoint of Tuberculosis -- 49. Tuberculosis: A Historical and Global Bioethical Perspective -- 50. The Problem of Tuberculosis: Myths, Stigma, and Mimics -- 51. Tuberculosis: Integrated Studies for a Complex Disease 2050.

Description / Table of Contents: Introduction on Integrated Science of Global Epidemics -- Emerging Viral Infections in Human Population -- One Health as An Integrated Approach: Perspectives from Public Services for Mitigation of Future Epidemics -- Multipronged Approach to Combat COVID-19: Lessons from Previous Pandemics for the Future -- Response to Disease Outbreaks in Africa: A Call to Build Resilient Health Systems -- Navigating Global Public Influenza Surveillance Systems for Reliable Forecasting -- Three Respiratory Syndrome Epidemics (SARS, MERS, COVID-19) in Two Decades: Clinical Epidemiological Considerations -- Epidemic in Complex Networks and Some Ideas About the Impact of Isolation Strategies in the Context of the COVID-19 Pandemic -- Optimal Control: Application and Applicability in Times of Pandemics -- Analysis of A COVID-19 Model Implementing SocialDistancing as An Optimal Control Strategy -- Impact of Policy Implementations on the Propagation of COVID-19 Before Vaccine -- Environmental Factors Associated with Global Pandemic Transmission and Morbidity -- Urbanization and the Epidemiology of Infectious Diseases: Towards the Social Framing of Global Responses -- Pandemics and Mass Casualties: Cornerstones of Management -- Social Marketing Contributions to Mitigate Global Epidemics -- The Significance of Super Intelligence of Artificial Intelligence Agencies in the Social Savageries of COVID-19: An Appraisal -- Integration of Sex and Gender Approaches in National Ethics Committees’ Mandate to Appraise COVID-19 Research Protocols: Lessons from West Africa -- Psychology, Law, Ethics, Telehealth, and the Global Pandemic -- Physical Inactivity, Sedentarism, and Low Fitness: A Worldwide Pandemic for Public Health -- The Global Epidemic of Diabesity: Are We Heading for An Unsustainable Future? -- Nutrition, Function, and Quality of Life in Older Adults Socially Isolated Due to the COVID-19 Pandemic: A Focus on Telehealth Interventions -- Africa’s Response to Pandemics -- Vaccine Hesitancy and Refusal: History, Causes, Mitigation Strategies -- Vaccine Compliance versus Trust in a Pandemic -- Child Development in A Crisis: A Pandemic -- HIV/AIDS Problems and Policies in Adolescent Population -- Addressing Needs of Foreign Schoolchildren to Combat a Global Epidemic of Dengue Virus Infection: Transnational and Trans-sectoral Initiatives -- Integrated Science of Global Epidemics 2050.

Description / Table of Contents: Chapter 1. Malignant Glioma -- Chapter 2. Benign Glioma -- Chapter3. Meningioma and Other Meningeal Tumors -- Chapter4. Epondymomas in Pediatric and Adults -- Chapter5. Medulloblastomas in Pediatric and Adults -- Chapter6. Benign and Malignant Tumors of The Pineal Region -- Chapter7. The Tumors of Choroid Plexus and Other Ventricular Tumors -- Chapter8. Embryonal Tumors of The Central Nervous System with Multilayered Rosettes and Atypical Teratoid/Rhabdoid Tumors -- Chapter9. Glioneuronal and Neuronal Tumors of the Central Nervous System -- Chapter10. Benign and Malignant Tumors of the Pituitary Gland -- Chapter11. Craniopharyngioma in Pediatric and Adults -- Chapter12. Schwannomas of Brain and Spinal Cord -- Chapter13. Other Nerve-Sheet Tumors of Brain and Spinal Cord -- Chapter14. Hemangioblastomas and Other Vascular Originating Tumors of Brain or Spinal Cord -- Chapter15. Brain and Spinal Cord Tumors of Embryonic Origin -- Chapter16. Brain and Spinal Tumors Originating from the Germ Line Cells -- Chapter17. Benign Brain and Spinal Tumors Originating from Bone or Cartilage -- Chapter18. Benign Spinal Tumors -- Chapter19. Other Less Prevalent Tumors of the Central Nervous System -- Chapter20. Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes -- Chapter21. Psychological and Psychiatric Aspects of Brain and Spinal Cord Tumors -- Chapter22. A Brief Explanation on Surgical Approaches for Treatment of Different Brain Tumors.

Description / Table of Contents: MATRICS – an update -- Cognitive [Computational] Neuroscience Test Reliability and Clinical Applications for Serious mental illness (CNTRaCS) Consortium: Progress and Future Directions -- Attention in Schizophrenia -- Perceptual Functioning -- Episodic Memory and Schizophrenia: From Characterization of Relational Memory Impairments to Neuroimaging Biomarkers -- Working Memory in People with Schizophrenia -- "Targeting Frontal Gamma Activity with Neurofeedback to Improve Working Memory in Schizophrenia" -- Cognitive Dysfunction as a Risk Factor for Psychosis -- Environmental Risk Factors and Cognitive Outcomes in Psychosis: Pre-, Perinatal, and Early Life Adversity -- Developmental manipulation-induced changes in cognitive functioning -- Genetic underpinnings of cognitive dysfunction in schizophrenia -- Primate models of cognitive deficit re schizophrenia -- Olfactory cognitive deficits -- Medication/Anticholinergic burden impacting cognition in schizophrenia An Update on Treatment of Cognitive Impairment Associated with Schizophrenia -- Cannabis & cognition -- Sex/gender differences -- Neuroinflammation linked to cognition.

Description / Table of Contents: 1. The human genome and its variations -- 2. Gene expression and chromatin -- 3. The basal transcriptional machinery -- 4. Transcription factors and signal transduction -- 5. A key transcription factor family: Nuclear receptors -- 6. DNA methylation -- 7. Histone modifications -- 8. Chromatin remodeling and organization -- 9. Regulatory impact of non-coding RNA -- 10. Genome-wide principles of gene regulation -- 11. Epigenetics in development -- 12. Epigenetics and aging -- 13. Epigenetics and disease -- 14. Cells and tissues of the immune system -- 15. Innate immunity and inflammation -- 16. Adaptive immunity and antigen receptor diversity -- 17. B cell immunity: BCRs, antibodies and their effector functions -- 18. Antigen-presenting cells and MHCs -- 19. T cell immunity: TCRs and their effector functions -- 20. Immunity to bacterial pathogens and the microbiome -- 21. Immunity to viral pathogens and the virome -- 22. Tolerance and transplantation immunology -- 23. Immunological hypersensitivities: Allergy and autoimmunity -- 24. Introduction to cancer -- 25. Oncogenes, signal transduction and the hallmarks of cancer -- 26 Tumor suppressor genes and cell fate control -- 27. Multistep tumorigenesis and genome instability -- 28. Cancer genomics -- 29. Cancer epigenomics.-30. Aging and cancer -- 31. Tumor microenvironment -- 32 Metastasis and cachexia -- 33. Cancer immunology -- 34 Architecture of cancer therapies -- 35 Nutrition and common diseases -- 36 Interference of the human genome with nutrients -- 37. Nutritional epigenetics, signaling and aging -- 38. Chronic inflammation and metabolic stress -- 39. Obesity -- 40. Insulin resistance and diabetes -- 41. Heart disease and the metabolic syndrome -- 42 Epigenetics, inflammation and disease.

Description / Table of Contents: Chaptre 1. Brain and Spinal Cord Tumors Among the Life-Threatening Health Problems: An Introduction -- Chaptre 2. Epidemiology of Brain and Spinal Cord Tumors -- Chaptre 3. The Role of Neuro-inflammation and Innate Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 4. The Role of Cellular Immunity and Adaptive Immunity in Pathophysiology of Brain and Spinal Cord Tumors -- Chaptre 5. Immunotherapy as a New Therapeutic Approach for Brain and Spinal Cord Tumors -- Chaptre 6. Cell of Origin of Brain and Spinal Cord Tumors -- Chaptre 7. The Role of Bioinformatics and Imaging Models in Tumorigenesis and Treatment Response of Brain and Spinal Cord Neoplasms -- Chaptre 8. The Role of Epigenetics in Brain and Spinal Cord Tumors -- Chaptre 9. Stem Cells and Targeted Gene Therapy in Brain and Spinal Cord Tumors -- Chaptre 10. Nutrition and Diet: A Double-Edged Sword in Development and Treatment of Brain Tumors -- Chaptre 11. The Role of Nanotechnology in Brain Tumors -- Chaptre 12. The Role of Nanotechnology in Spinal Cord Tumors -- Chaptre 13. The Economic Burden of Malignant Brain Tumors.

Description / Table of Contents: Part 1: Knockouts and animal models -- Integrins α1β1 and α2β1 – The generalist collagen receptors -- Roles for Integrin α3β1 in Development and Disease -- Part 2: Fibrosis& Cancer -- Integrins: Key targets in tissue fibrosis and tumor stroma -- Integrins in Cardiac Form, Function and Disease -- Integrin 8 and its ligand nephronectin in health and disease -- v integrin-dependent TGF activation in cancer: a brief update -- Part 3: Human disease -- a11b1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis -- Integrins in pathological tissue remodelling of joints -- α4 integrins in immune homeostasis and disease -- β2-integrins in immunity: new roles for old players -- Structure and function of the leukocyte integrin αMβ2 -- Part 4: Integrins in hemostasis, and immune control -- Platelet integrins: Critical mediators of haemostasis and pathological thrombus formation -- Integrins as receptors for bacterial and viral pathogens.

Description / Table of Contents: Chapter 1 A short introduction to vaccines -- Chapter 2 Thermostability of vaccines -- Chapter 3 Drying technologies for vaccines -- Chapter 4 Aseptic spray drying technology -- Chapter 5 Design of experiment studies and scale-up -- Chapter 6 Applications of spray dried vaccines.-Chapter 7 Conclusions and future perspectives of spray-dried vaccines.

Description / Table of Contents: Part I. Microscopy -- Chapter 1. Advances in Microscopy and Its Applications with Special Reference to Fluorescence Microscope: An Overview -- Chapter 2. Visualisation of Host-Pathogen Communication -- Chapter 3. A Review of Pathology and Analysis of Approaches to Easing Kidney Disease Impact: Host-Pathogen Communication and Biomedical Visualization Perspective -- Part II. Radiology and Patient Care -- Chapter 4. The Evolution of Equipment and Technology for Visualising the Larynx and Airway -- Chapter 5. The Impact of Technological Innovation on Dentistry -- Chapter 6. Advanced 3D Visualization and 3D Printing in Radiology -- Chapter 7. 3D Visualisation of the Spine -- Part III. Anatomy Education -- Chapter 8. Visualization in Anatomy Education -- Chapter 9. Visualizing Anatomy in Dental Morphology Education -- Chapter 10. Flashcards: The Preferred Online Game-Based Study Tool Self-Selected by Students to Review Medical Histology Image Content.

Description / Table of Contents: 1. Implications of renin-angiotensin system in health and disease -- 2. Renin angiotensin system and aging -- 3. The interplay of the renin-angiotensin system and solid organ transplantation -- 4. Correlation between renin angiotensin system and infectious disease -- 5. Emerging contributions of endocrine pathophysiology in virus-related infectious disease -- 6. Understanding the renin-angiotensin system in coronavirus disease 2019 -- 7. Metabolomics approach in differentiating RAS responses in ARDS (Acute respiratory distress syndrome) and SAR-CoV-2 -- 8. A Comprehensive review of the impact of the renin angiotensin system in the liver, lung, infectious diseases and cancers -- 9. Application of biosensors for monitoring changes in renin angiotensin system (RAS) in cancers and lung diseases -- 10. Bioinformatics study on renin angiotensin in lung, and liver cancer using plant-based extracts -- 11. Role of renin-angiotensin system in the pathogenesis and progression of non-alcoholic fatty liver -- 12. The classical and nonclassical renin-angiotensin-aldosterone system in liver cirrhosis -- 13. Renin-angiotensin-aldosterone system role in organ fibrosis -- 14. Role of renin angiotensin-aldosterone system in kidney homeostasis -- 15. Renin-angiotensin system in chronic kidney disease: Implications in stroke outcome -- 16. The renin-angiotensin system and cancer -- 17. Renin-angiotensin system and cancer: From laboratory to clinics -- 18. Role of renin-angiotensin system in cancer cachexia -- 19. Renin angiotensin system activity in different cancers: Mechanistic insight and preclinical studies -- 20. The new dimension of the renin-angiotensin system in the hallmarks of cancer -- 21. Renin-angiotensin system in hematological malignancies -- 22. Renin angiotensin system (RAS): The common thread between cancer and heart failure -- 23. Renin-angiotensin system: a potential therapeutic target for colorectal cancer -- 24. Anticancer role of natural phenolic acids by targeting angiotensin-converting enzyme (ACE) -- 25. Angiotensin-(1-7): A Prospective Cancer Therapeutic.

Description / Table of Contents: Preface (Brianne K. Connizzo, Lin Han, Robert L. Sah) -- Scientific Impact -- Chapter 1. Aggrecan and Hyaluronan: The infamous Cartilage Polyelectrolytes- Then and Now (Anna Plaas, Meghan Moran, John Sandy, Vincent Hascall) -- Chapter 2. Understanding the Influence of Local Physical Stimuli on Chondrocyte Behavior (Byumsu Ki, Lawrence J. Bonassar) -- Chapter 3. Multiscale In Silico Modeling of Cartilage Injuries (Rami K. Korhonen, Atte S.A. Eskelinen, Gustavo A. Orozco, Amir Esrafilian, Cristina Florea, and Petri Tanska) -- Chapter 4. In Vitro Models and Proteomics in Osteoarthritis Research (Martin Rydén, Patrik Önnerfjord) -- Chapter 5. Nanomechanics of Aggrecan: A New Perspective on Cartilage Biomechanics, Disease and Regeneration (Chao Wang, Elizabeth R. Kahle, Lin Han) -- Chapter 6. Computational Modelling for Managing Pathways to Cartilage Failure (Saeed Miramini, David W. Smith, Bruce S. Gardiner, Lihai Zhang) -- Chapter 7. Gene Delivery to Chondrocytes (Christopher V. Nagelli, Christopher H. Evans, Rodolfo E. De la Vega) -- Chapter 8. Mechanical Articular Cartilage Injury Models and Their Relevance in Advancing Therapeutic Strategies (Bodo Kurz, Melanie L Hart, Bernd Rolauffs) -- Chapter 9. Hip Osteoarthritis: Bench to Bedside Perspective (Young-Jo Kim) -- Chapter 10. Harnessing Growth Factor Interactions to Optimize Articular Cartilage Repair (Stephen B. Trippel) -- Personal Tributes -- Index.

Description / Table of Contents: Chapter 1. Lysine demethylation in pathogenesis -- Chapter 2. Targeting the LSD1/KDM1 Family of Lysine Demethylases in Cancer and Other Human Diseases -- Chapter 3. KDM2 demethylases as drug targets -- Chapter 4. Role of histone demethylase KDM3 (JMJD1) in transcriptional regulation and cancer progression -- Chapter 5. KDM4 demethylases as drug targets -- Chapter 6. KDM5 lysine demethylases in pathogenesis, from basic science discovery to the clinic -- Chapter 7. Context-dependent functions of lysine demethylases in physiology and disease -- Chapter 8. KDM7 demethylases as drug targets.

Description / Table of Contents: Part I: Manufacturing of Recombinant Therapeutic Proteins -- Chapter 1. Single-Use Systems in Biopharmaceutical Manufacture: State of the Art and Recent Trends (Jossen et al.) -- Chapter 2. Recent Developments in Bioprocess Monitoring Systems (Rahmatnejad et al.) -- Chapter 3. Advances in Characterization of Industrial Bioreactors for Cell Culture Process (Fitschen et al.) -- Chapter 4. Continuous Bioprocessing for Upstream Process - Perfusion Process (Chotteau et al.) -- Chapter 5. Continuous Bioprocessing for Downstream (Gerstweiler) -- Chapter 6. Towards Digital Twin for Biopharmaceutical Processes: Concept and Progress (Ding et al.) -- Chapter 7. Integrated Process and Supply Chain Design and Optimization (Triantafyllou et al.) -- Chapter 8. Production of Complex Proteins in Plants – From Farming to Manufacturing (Nausch et al.) -- Chapter 9. Manufacturing of Recombinant Proteins Using Quality by Design (QbD) Methodology: Current Trend and Challenges (Shin and Landauer) -- Chapter 10. Biopharma 4.0 for Biologics Manufacturing Under Pandemic Constraints (Schmidt et al.) -- Chapter 11. Biopharma 4.0: Digital Technologies Driving Smart Manufacturing (Nargund et al.) -- Part II: Manufacturing Aspects of Cell and Gene Therapy -- Chapter 12. Essential Aspects of Mesenchymal Stem Cell Manufacturing (Fleischhammer et al.) -- Chapter 13. Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Opportunities and Challenges for a Robust and Scalable Expansion Process (Tasto and Salzig) -- Chapter 14. Biomanufacturing Aspects of Gene Therapy (Warnock) -- Chapter 15. Manufacturing and Quality of Advanced Therapeutics: Cellular Therapies, CAR-T and Gene Therapies (van den Bos et al.).

Description / Table of Contents: 1. Introductory chapter: Early applications and evolution of blockchain implementations in medicine -- 2. Can Blockchain Technology Change Contemporary Medicine As It Is Currently Understood? -- 3. The Current State of Healthcare Information Exchange (HIE) and Proposing a Blockchain HIE Infrastructure -- 4. An amalgamation of blockchain and connected health for combating COVID-19 -- 5. Applications of Blockchain Technology in the COVID-19 Era. 6. Distributed Ledgers and Immunity Passports: The Intersection of Clinical Medicine and Digital Technology -- 7. Digital Identity, Computational Reliabilism, and the Future of IOMT: Epistemic Reasoning and The Role of Blockchain in Removing Human Tampering from Pharmacovigilance Decision Making -- 8. Potential implementations of blockchain technology in patient safety: A high-level overview -- 9. Blockchain in Medical Education -- 10. Blockchain in Education: Linking Competency Assessment with Credentialing -- 11. Optimizing Blockchain Technology in Academic Medicine -- 12. Distributed Research Networks -- 13. Use of Blockchain Technology for Implantable Medical Device Tracking -- 14. Application of Blockchain Technology in Healthcare Supply Chains.

Description / Table of Contents: 1. Principles of molecular recognition -- 2. Theoretical Aspects -- 3. Molecular Recognition Units in Sensor Constructions -- 4. Binding blocks and Interfaces Designed for Sensing -- 5. Probing the properties of continuous media and interfaces -- 6. Detection of Ions and Low-molecular Targets -- 7. Detection of Biological Macromolecules and Recognition of harmful microbes -- 8. Sensing Inside the Living Cells -- 9. Ex-vivo Clinical Diagnostics -- 10. Imaging in vivo -- 11. Theranostics: Combining Targeting, Imaging and Therapy -- 12. Opening new horizons.

Description / Table of Contents: Chap 1. Research Environment -- Chap 2. Training, Supervision and Mentoring -- Chap 3. Research Procedures -- Chap 4. Safeguards -- Chap 5. Data Practices and Management -- Chap 6. Collaborative Working -- Chap 7. Publication and Dissemination -- Chap 8. Reviewing, Evaluating and Editing -- Chap 9. How to deal with allegations of misconduct.

Description / Table of Contents: Part. I. History, Recollections, And Homages -- Paradigm Shifts in the History of Nox2 and Its Regulators: An Appreciative Critique -- The Phagocyte Oxidase: The Early Years -- Reflections on My Life in Noxes -- The Discovery and Characterisation of Nox2, a Personal Journey -- Reminiscences on Positional Cloning of X-CGD Gene (Aka CYBB, gp91phox, Nox2) -- On Katsuko Kakinuma: Spectroscopic Studies of Redox Centers in NADPH Oxidase “Identifying and Observing the Key Players That Pass an Electron to Oxygen” -- Pierre Vignais, from One Respiratory Chain to Another -- Gary M. Bokoch, the Rac-n-Rho Man: His fascination with Rho-GTPases -- History and Discovery of the Noxes: From Nox1 to the DUOXes -- Part. II. Canonical NADPH Oxidases -- NADPH Oxidase 1: At the Interface of the Intestinal Epithelium and Gut Microbiota -- Physiological Functions and Pathological Significance of NADPH Oxidase 3 -- Nox 4: From Discovery to Pathophysiology -- Nox5 - Molecular Regulation and Pathophysiology -- DUOX1 and DUOX2, DUOXA1 and DUOXA2 -- Part. III. NADPH Oxidase Regulators -- p47phox and NOXO1, the Organizer Subunits of the NADPH Oxidase 2 (Nox2) and NADPH Oxidase 1 (Nox1) -- The NADPH Oxidase Activator p67phox and Its Related Proteins -- p40phox: Composition, Function and Consequences of Its Absence -- Rho Family GTPases and their Modulators -- Part IV. Tools, Inhibitors, and Neighbors -- Tools to Identify Noxes and their Regulators -- Methods to Measure Reactive Oxygen Species Production by NADPH Oxidases -- Isoform-Selective Nox Inhibitors: Advances and Future Perspectives -- Proteins Cross-talking with Nox Complexes: The Social Life of Noxes -- Part V. Non-Mammalian NADPH Oxidases -- NADPH Oxidase-Dependent Processes in the Social Amoeba Dictyostelium Discoideum -- Discovery and Functional Analysis of the Single-Celled Yeast NADPH Oxidase, Yno1 -- NADPH Oxidases in Fungi -- Plant NADPH Oxidases -- Nematode Noxes: The DUOXes of Caenorhabditis elegans -- NADPH Oxidases in Arthropods -- NADPH Oxidases in Zebrafish -- Part VI. Structure -- Structural Insights into the Mechanism of DUOX1-DUOXA1 Complex -- Structure, Function and Mechanism of Six-Transmembrane Epithelial Antigen of the Prostate (STEAP) Enzymes -- Part VII. Pathology -- Chronic Granulomatous Disease -- Definitive Treatments for Chronic Granulomatous Disease with a Focus on Gene Therapy -- Part VIII. Future -- Quo Vadis NADPH Oxidases: Perspectives on Clinical Translation.

Description / Table of Contents: Chapter 1: Biochemistry of hyaluronan synthesis -- Chapter 2: Update on hyaluronan in development -- Chapter 3: Long non-coding RNAs and epigenetic regulation of hyaluronan synthesis -- Chapter 4: The hyaluronan-rich zones of plasma membrane protrusions and extracellular vesicles -- Chapter 5: Hyaluronan in Kidney Fibrosis -- Chapter 6: Inter-α-inhibitor proteins: A review of structure and function -- Chapter 7: CD44: Does CD44v6 adversely impact the prognosis of cancer patients? -- Chapter 8: The pharmacokinetics and pharmacodynamics of 4-methylumbelliferone and its glucuronide metabolite in mice -- Chapter 9: The role of hyaluronan in skin wound healing -- Chapter 10: Sulfated hyaluronan: a novel player in cancer therapeutic and bioengineering approaches.

Description / Table of Contents: Chapter 1. Introduction and History of Meningiomas -- Chapter 2. Clinical Presentation and Prognosis -- Chapter 3. Imaging Characteristics of Meningiomas -- Chapter 4. Histopathology of Meningiomas -- Chapter 5. Skull Base Meningiomas -- Chapter 6. Spinal Meningiomas -- Chapter 7. Surgical Therapies -- Chapter 8. Radiation Therapies -- Chapter 9. Illustrative Cases -- Chapter 10. Advances in CNS Tumor Classification -- Chapter 11. Genomic Landscape -- Chapter 12. Radiation-Induced Meningiomas -- Chapter 13. Meningioma Predisposing Syndromes -- Chapter 14. Epigentic Landscape -- Chapter 15. Immune Profile -- Chapter 16. PDX Models/Mouse Models/Cell Lines -- Chapter 17. Novel Medical Therapies -- Chapter 18. Quality of Life in Menigioma Patients -- Chapter 19. Illustrative Cases: Revisited with Adjuvant Molecular Data -- Chapter 20. Future Directions in Management.

Description / Table of Contents: Preface -- Part I: Backscatter Coefficient methods -- Chapter 1. Quantitative Ultrasound: an Emerging Technology for Detecting, Diagnosing, Imaging, Evaluating, and Monitoring Disease (Ernie Feleppa) -- Chapter 2. Quantitative Ultrasound: Scattering theory (Michael Oelze) -- Chapter 3. Quantitative Ultrasound: Experimental implementation (Michael Oelze) -- Chapter 4. Extracting Quantitative Ultrasonic Parameters from the Backscatter Coefficient (Aiguo Han) -- Part II: Attenuation Estimation Methods -- Chapter 5. Attenuation Compensation and Estimation (Timothy Bigelow and Yassin Labyed) -- Chapter 6. Recent advances in attenuation estimation (Ivan Rosado Mendez) -- Part III: Envelope Statistics Methods -- Chapter 7. Review of envelope statistics models for quantitative ultrasound imaging and tissue characterization (Francois Destrempes and Guy Cloutier) -- Chapter 8. Information entropy and its applications (Po-Hsaing Tsui) -- Part IV: Ultrasound Computed Tomography -- Chapter 9. Ultrasound Tomography (Nicole Ruiter, Torsten Hopp, Michael Zapf and Hartmut Gemmek) -- Chapter 10. Full Wave Inversion and Inverse Scattering in Ultrasound Tomography/Volography (James Wiskin) -- Chapter 11. Clinical Importance of 3D Volography in Breast Imaging (John Klock) -- Part V: Acoustic microcopy -- Chapter 12. Acoustic Microscopy (Yoshifumi Saijo) -- Chapter 13. Advanced Topics in Quantitative Acoustic Microscopy (Cameron Hoerig and Jonathan Mamou) -- Part VI: Phantoms for Quantitative Ultrasound -- Chapter 14. Phantoms for Quantitative Ultrasound (Tim Stiles) -- Index.

Description / Table of Contents: Foreword: Challenges & Opportunities for LGBT Populations and Cancer in Global Oncology -- Introduction -- Africa -- A Double Dose Of Stigma – Being Gay And Living With Cancer In Kenya -- Sexual Orientation, Gender Identity and Cancer in South Africa -- Americas -- Making the Situation of TLGBI People around Cancer visible: Observations from the Andean Region -- Cancer Care Challenges for the LGBT Population in Brazil -- Cancer and the SGM Population in Canada and the United States of America -- South-East Asia -- The South-East Asia Region: Societal Conditions for LGBT Health and Cancer Research -- Europe -- Foreword: The Eurocentralasian Lesbian* Community Perspective on Cancer and LBQ women: Advocating for more Research and Activism Collaboration -- LGBT+ and Cancer in the WHO European Region: Current Situation in 12 Eastern European and Central Asian Countries -- Sexual and Gender Minorities and Cancer in Germany: The Striking Absence of Understanding their Cancer-related Needs -- LGBT Populations and Cancer in the UK -- Eastern Mediterranean -- LGBT Populations and Cancer in the Eastern Mediterranean Region: Insights and Challenges with a Focus on Lebanon -- Western Pacific -- LGBT Populations and Cancer in Australia and New Zealand -- Challenges in Cancer Control Confronting the LGBT Population in China: Health Risks, Unique Barriers, and Unmet Needs -- What Have We Learned about Cancer and the Global LGBT Community? -- Index.

Description / Table of Contents: Introduction -- Batch Processing Methods in ImageJ -- Python: Data Handling, Analysis and Plotting -- Building a Bioimage Analysis Workflow Using Deep Learning -- GPU-Accelerating ImageJ Macro Image Processing Workflows Using CLIJ -- How to Do the Deconstruction of Bioimage Analysis Workflows: A Case Study with SurfCut -- i.2.i. with the (Fruit) Fly: Quantifying Position Effect Variegation in Drosophila Melanogaster -- A MATLAB Pipeline for Spatiotemporal Quantification of Monolayer Cell Migration.

Description / Table of Contents: Preface -- Chapter1. Advances in experimental research about periodontitis: lessons from the past, ideas for the future (Julien Santi-Rocca) -- Part I: Periodontal microbiota -- Chapter 2. Microbiota in Periodontitis: advances in the omic era (Shao Bing Fong, Emile Boyer, Martine Bonnaure-Mallet, Vincent Meuric) -- Chapter 3. Aggregatibacter actinomycetemcomitans: from basic to advanced research (Abdelhadi Hbibi, Amal Bouziane, Badiaa Lyoussi, Mimoun Zouhdi, Driss Benazza) -- Chapter 4. Meta-analyses on the Periodontal Archaeome (Jéssica Alves de Cena, Yuri Silvestre-Barbosa, Aline Belmok, Cristine Miron Stefani, Cynthia Maria Kyaw, Nailê Damé-Teixeira) -- Chapter 5. Parasites in periodontal health and disease: a systematic review and meta-analysis (David Felipe Martin-Garcia, Malik Sallam, Gabriela Garcia, Julien Santi-Rocca) -- Chapter 6. Fungi - a component of the oral microbiome involved in periodontal diseases (Justyna Karkowska-Kuleta, Dorota Satala, Magdalena Smolarz, Marcin Zawrotniak, Maria Rapala-Kozik) -- Chapter 7. Herpesviruses in periodontitis: An umbrella review (Aleksandar Jakovljevic, Miroslav Andric, Jelena Jacimovic, Jelena Milasin, Javier Enrique Botero) -- Part II: Periodontitis pathophysiology -- Chapter 8. Recent updates on microbial biofilms in periodontitis: an analysis of in vitro biofilm models (Maick Meneguzzo Prado, Nathalia Figueiredo, Andréa Pimenta, Tamires Szeremeske Miranda, Magda Feres, Luciene Cristina Figueiredo, Josiane de Almeida, Bruno Bueno-Silva) -- Chapter 9. Update on B cell response in periodontitis (Julien Demoersman, Jacques Olivier Pers) -- Chapter 10. Polarization profiles of T lymphocytes and macrophages responses in periodontitis (Franco Cavalla, Marcela Hernández) -- Chapter 11. Complementary experimental methods in genetics open up new avenues of research to elucidate the pathogenesis of periodontitis (Arne S. Schaefer) -- Part III: Periodontitis-associated conditions -- Chapter 12. Update on the bidirectional link between diabetes and periodontitis (Leila Salhi, Michèle Reners) -- Chapter 13. Periodontitis as a risk factor for Alzheimer’s disease: the experimental journey so far, with hope of therapy (Alice Harding, Shalini Kanagasingam, Richard Welbury, Sim K. Singhrao) -- Chapter 14. Cardiovascular diseases and periodontitis (Peter Riis Hansen, Palle Holmstrup) -- Part IV: Therapeutic management of periodontitis -- Chapter 15. Update on the role of cytokines as oral biomarkers in the diagnosis of periodontitis (Triana Blanco-Pintos, Alba Regueira-Iglesias, Carlos Balsa-Castro, Inmaculada Tomás) -- Chapter 16. Non-surgical periodontal treatment: SRP and innovative therapeutic approaches (Alexia Vinel, Antoine Al Halabi, Sébastien Roumi, Hélène Le Neindre, Pierre Millavet, Marion Simon, Constance Cuny, Jean-Sébastien Barthet, Pierre Barthet, Sara Laurencin-Dalicieux) -- Chapter 17. Update on the roles of oral hygiene and plaque control on periodontal disease (Leila Salhi, Bruno De Carvalho, Michèle Reners) -- Chapter 18. Multi-photonic adjunctive therapy for the management of periodontitis: recent advances and new treatment approach (Marco Giannelli, Daniele Bani) -- Chapter 19. Probiotics during the therapeutic management of periodontitis (Flavia Furlaneto, Karin Hitomi Ishikawa, Michel Reis Messora, Marcia P A Mayer) -- Chapter 20. Periodontal cell therapy: a systematic review and meta-analysis (Antoine Dubuc, Valérie Planat-Bénard, Mathieu Marty, Paul Monsarrat, Philippe Kémoun) -- Index.

Description / Table of Contents: A historical and evolutionary view of tight junctions -- Tricellular tight junctions -- Mechanosensitivity of tight junctions -- Intracellular traffic and non-canonical roles of ZO-2 protein -- Impact of claudin-2 and occludin expression in inflammation disorders -- Tight junctions in the inflamed gut -- Intestinal barrier disruption by enteropathogenic Escherichia coli -- Tight junction barrier function regulation by microbiota -- Claudin-7 participation in cell-substrate adhesion, cell migration, salt balance in the renal collecting duct and gut cell renewal and differentiation -- Regulation of the alveolar epithelial barrier by claudin-5 -- Regulation of the blood-retinal barrier by occludin phosphorylation, norrin and sonic hedgehog signaling -- Transmigration of metastatic cells through the blood-brain barrier -- Endocytosis of tight junction proteins -- Regulated degradation of claudins. .

Description / Table of Contents: 1. Alkanes, composition, constitution, and configuration -- 2. Functional groups -- 3. Electronic structure of organic molecules -- 4. Alkenes and alkynes -- 5. Substitutions on saturated carbon atom -- 6. Nucleophilic additions -- 7. Stereochemistry, symmetry, and molecular chirality -- 8. Derivatives of carboxylic acids -- 9. Electrophilic substitutions -- 10. Pericyclic reactions -- 11. Organic natural products -- 12. Organic supramolecular and supermolecular structures.

Description / Table of Contents: Part 1: Functions of Macropinocytosis -- Chapter 1: Functional Diversity of Macropinocytosis -- Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways -- Chapter 3: The amoebal model for micropinocytosis -- Chapter 4: Extracellular ATP and macropinocytosis -- Chapter 5: Macropinocytosis and Cell Migration: Don't drink an drive -- Chapter 6: Macropinocytosis in phagocyte function and immunity -- Part 2: Signaling Mechanisms Driving Macropinocytosis -- Chapter 7: Roles of 3' Phosphoinositides in Macropinocytosis -- Chapter 8: Signaling pathways that regulate macropinocytosis in mammalian cells -- Chapter 9: Wnt, GSK3 and Macropinocytosis -- Chapter 10: Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis -- Chapter 11: Kras-independent macropinocytosis in pancreatic cancer.

Description / Table of Contents: Chapter 1. The hope and the hype in organoid technology in regenerative medicine (Badrul Hisham Yahaya) -- Chapter 2. Pluripotent stem cell derived and adult-tissue-derived organoid (Tiago G. Fernandes) -- Chapter 3. Generation of human organoid for 3D stem cell culture Hans Clevers -- Chapter 4. Organogenesis in a dish: Organ developmental study using organoid technology (Kursad Tuksen) -- Chapter 5. Disease modelling using patient-derived organoid (Narisorn Kitiyanant) -- Chapter 6. Tumor organoid as a model to study cancer microenvironment (Ahmad Faried) -- Chapter 7. Gene-editing in organoid to improve understanding of human disease (Yinming Liang) -- Chapter 8. Organoid culture as a good model to study lung development (Mitsuru Morimoto) -- Chapter 9. Organoid as good model for respiratory diseases (Badrul Hisham Yahaya).-Chapter 10. In vitro 3D model on reproductive system (Ruttachuk Rungsiwiwut) -- Chapter 11. Modelling of neuronal organoid: The way forward and challenges (Juntang Lin) -- Chapter 12. Generation of cardiac organoid in early heart organogenesis (Tan Jun Jie) -- Chapter 13. Neural Crest-Derived Stem Cells in organoid development for neurodegenerative disease modelling (Darius Widera) -- Chapter 14. Organoid for drug discovery and personalized treatment (Toshio Takahashi) -- Chapter 15. Ethical concern on patient-derived organoid (Phuc Van Pham).

Description / Table of Contents: Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges -- Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer -- Ion Channels in Cancer: Orchestrators of Electrical Signaling and Cellular Crosstalk -- Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics -- Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research -- Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions -- Ion Transport and Radioresistance -- Ion Transporting Proteins and Cancer: Progress and Perspectives.

Description / Table of Contents: Molecular Mechanisms of SARS-CoV-2/COVID-19 Pathogenicity on the Central Nervous System: Bridging Experimental Probes to Clinical Evidence and Therapeutic Interventions -- The Probable Protective Effect of Photobiomodulation on the Inflammation of the Airway and Lung in COVID-19 Treatment: A Preclinical and Clinical Meta-Analysis -- Metabolomics Signatures of SARS-CoV-2 Infection -- Autophagic Mediators in Bone Marrow Niche Homeostasis -- Pluripotency Stemness and Cancer: More Questions than Answers -- In Vitro Culturing of Adult Stem Cells: The Importance of Serum and Atmospheric Oxygen -- Mouse Models of Asthma: Characteristics, Limitations and Future Perspectives on Clinical Translation -- From Cells to Organs: The Present and Future of Regenerative Medicine -- Tissue-Restricted Stem Cells as Starting Cell Source for Efficient Generation of Pluripotent Stem Cells: An Overview -- Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium.

Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.

Description / Table of Contents: Part I. Healthcare -- Chapter 1. Is It Time to FONA Friend? A Novel Mixed Reality Front of Neck Access Simulator -- Chapter 2. “Learning About Skin Breakdown” – Design, Development and Evaluation of an Augmented Reality Application to Inform about Pressure Ulcers (sores) and Moisture Lesions -- Chapter 3. The Use of 3D-Printing and Injection Moulding in the Development of a Low-Cost, Perfused Renal Malignancy Model for Training of Robot-Assisted Laparoscopic Partial Nephrectomy -- Chapter 4. The Co-IMMUNicate App: An Engaging and Entertaining Education Resource on Immunity to Respiratory Viruses -- Part II. Education -- Chapter 5. Application of AR and 3D Technology for Learning Neuroanatomy -- Chapter 6. Communicative Powers of Interactive Digital Mediums in the Field of Polyomics -- Chapter 7. SkilletonVR: Canine Skeleton VR -- Chapter 8. Using Holograms to Engage Young People with Anatomy -- Chapter 9. The Digital Dolphin: Are 3D Mobile Based and Interactive Models a Useful Aid to Volunteers on Stranding Schemes Learning the Basic Anatomy and Pathology of Cetaceans? -- Chapter 10. The Impact of the COVID Crisis on Anatomical Education: A Systematic Review.

Description / Table of Contents: Chapter 1. Mechanisms and biological roles of DNA methyltransferases and DNA methylation – from past achievements to future challenges -- Chapter 2.Bacterial DNA Methylation and Methylomes -- Chapter 3. ChapterDomain Structure of the Dnmt1, Dnmt3a, and Dnmt3b DNA Methyltransferases -- Chapter 4. Enzymology of Mammalian DNA Methyltransferases -- Chapter 5. Genetic Studies on Mammalian DNA Methyltransferase -- Chapter 6. Structure and Mechanism of Plant DNA Methyltransferases -- Chapter 7. DNA Methylation in Honey Bees and the Unresolved Questions in Insect Methylomics -- Chapter 8. N6-Methyladenine: A Conserved and Dynamic DNA Mark -- Chapter 9. Pathways of DNA Demethylation -- Chapter 10. Structure and Function of TET Enzymes -- Chapter 11.Proteins That Read DNA Methylation -- Chapter 12. Recent advances on DNA base flipping – a general mechanism for writing, reading, and erasing DNA modifications.-Chapter 13. The Role of DNA Methylation in Cancer -- Chapter 14. DNMTs and DNA damage -- Chapter 15. Role of DNMTs in brain -- Chapter 16. Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns.-Chapter 17. Inhibitors of DNA methylation -- Chapter 18. Rewriting DNA Methylation Signatures at Will: The Curable Genome Within Reach? -- Chapter 19. DNA Labeling Using DNA Methyltransferases.

Description / Table of Contents: Chapter 1. The tumor microenvironment -- Chapter 2. Methods of formulation of polymeric nanoparticles -- Chapter 3. Natural polymers based nanoparticles targeted to solid tumors -- Chapter 4. Optimization of physicochemical properties of polymeric nanoparticles for targeting solid tumors -- Chapter 5. Passive and active targeting approaches for solid tumors -- Chapter 6. Polymeric nanoparticles entrapping natural drugs for cancer therapy -- Chapter 7. Polymeric nanoparticles entrapping drug combinations targeted to solid tumors -- Chapter 8. Ligands specific to over-expressed receptors in solid tumors -- Chapter 9. Ligand targeted polymeric nanoparticles for cancer chemotherapy -- Chapter 10. Polymeric nanoparticles as theranostics for targeting solid tumors -- Chapter 11. Oral delivery of polymeric nanoparticles for solid tumors -- Chapter 12. Polymeric nanoparticles to target glioblastoma tumors -- Chapter 13. Polymeric nanoparticles to target lung cancer -- Chapter 14. Polymer based nanoplatforms for targeting breast cancer -- Chapter 15. PH-Sensitive polymeric nanoparticles for cancer treatment -- Chapter 16. Polymeric nanoplatforms for targeted treatment of prostate cancer -- Chapter 17. Cellular internalization and toxicity of polymeric nanoparticles -- Chapter 18. Prospects and challenges in the treatment of solid tumors.

Description / Table of Contents: Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury -- Imaging cerebral energy metabolism in healthy infants -- Changes in cerebral oxygenation and systemic physiology during a verbal fluency task: Differences between men and women -- Brain Tissue Conductivity in Focal Cerebral Ischemia -- Physical stress Attenuates Cognitive inhibition: An fNIRS Examination -- Changes in Prefrontal Cortical Oxygenation During Tilt Table Orthostatic Hypotension in Subarachnoid Haemorrhage Patients -- Effects of different optical properties of head tissues on near-infrared spectroscopy Using Monte Carlo Simulations -- Frontal cerebral oxygenation in humans at rest: A mirror symmetry in the correlation with cardiorespiratory activity -- Photomodulation of lymphatic delivery of bevacizumab to the brain: the role of singlet oxygen -- NIRS-based study of local cerebral oxygenation during transcranial direct current stimulation in patients with mild traumatic brain injury -- Postnatal Exposure to Brief Hypoxia Alters Brain VEGF Expression and Capillary Density in Adult Mice -- Impaired Cognitive Performance in Mice Exposed to Prolonged Hyperoxia -- Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain -- Motor Imagery and Frontal Head Oxygenation: An fNIRS Study -- Non-invasive detection of persistent cortical hypoxia in Multiple Sclerosis using frequency domain near-infrared spectroscopy (fdNIRS) -- Evaluation of intraoperative end-tidal Carbon dioxide change relates to length hospitalization in peridiaphragmatic surgery: a pilot study -- Pulmonary Embolism in COVID-19 patients is not related to a worsening in tissue oxygenation -- Cardiovascular risk score and gas exchange in COVID-19 patients: no correlation -- Heme Oxygenase 1/ High Mobility Group Box 1 pathway may have a possible role in Covid-19 ARDS (Acute respiratory distress syndrome): a pilot histological study -- Silent Hypoxemia in COVID-19 pneumonia -- Low Flow and Microvascular Shunts: A Final Common Pathway to Cerebrovascular Disease: A Working Hypothesis -- A case of intracranial vertebral artery stenosis treated with percutaneous transluminal angioplasty and stenting guided by brain oximetry -- Assessment of Optimal Arterial Pressure with Near-Infrared Spectroscopy in Traumatic Brain Injury Patients -- Effects of exercise-diet therapy on cognitive function in healthy elderly people evaluated by deep learning based on basic blood test data -- NIRS studies show reduced interhemispheric functional connectivity in individuals with Multiple Sclerosis that exhibit cortical hypoxia -- Eye Tracking Parameters Correlate With the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study -- Critical closing pressure of cerebral circulation at concomitant moderate-to-severe traumatic brain injury -- Hybrid convolutional neural network (hCNN) for image reconstruction in near-infrared optical tomography -- Cross-frequency coupling between brain and body biosignals: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Machine learning distinguishes familiar from unfamiliar pairs of subjects performing an eye contact task: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates With Asphyxia -- Basic examination of hemoglobin phase of oxygenation and deoxygenation in resting state and task periods in adults using fNIRS -- Development and validation of robust and cost-effective liquid heterogeneous phantom for time domain near-infrared optical tomography -- Effect of Exercise Therapy on Stress Response Evaluated by IoMT Monitoring System -- Improved optical tissue model for tissue oximetry imaging applications -- In vitro validation of a new tissue oximeter using visible light -- Photon and Proton Dose Painting based on Oxygen Distribution – Feasibility Study and Tumour Control Probability Assessment -- Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells -- Feasibility of non-invasive measurement of tumor NAD(H) by in vivo phosphorus-31 magnetic resonance spectroscopy -- Acidosis-induced regulation of Egr1 and Ccn1 in vitro and in experimental tumors in vivo -- Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours -- Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers upon Mild Hyperthermia Delivered by wIRA-Irradiation -- Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy -- Optical Redox Imaging Is Responsive to TGFβ Receptor Signaling in Triple-Negative Breast Cancer Cells -- Evaluation of betulinic acid derivatives as PET tracers for hypoxia-induced carbonic anhydrase IX (CA IX) expression -- Role of the mTOR signaling pathway during extracellular acidosis in tumor cells -- Feasibility Study of Remote Contactless Perfusion Imaging with Consumer-Grade Mobile Camera -- Stability of a Novel PEGylation site on a Putative Hemoglobin Based Oxygen Carrier -- Oxygen storage in stacked phospholipid membranes under an oxygen gradient as a model for myelin sheaths -- Confocal laser and electron microscopic investigation of gap junctions in anaplastic astrocytomas -- A radiation biological analysis of the oxygen effect as a possible mechanism in FLASH -- Assessment of nicotinamide adenine dinucleotide in human tissues by in vivo phosphorus-31 magnetic resonance spectroscopic imaging at 1.5 Tesla -- Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus -- Hemorheologic Enhancement of Cerebral Perfusion increases oxygen supply and reduces Ab plaques deposition in a mouse model of Alzheimer’s Disease -- Calorimetric Characterization of the Binding Reaction Between Human Ferric Hemoglobins and Haptoglobin to Develop a Drug for Removal of Cell-Free Haemoglobin -- Feasibility To Measure Tissue Oxygen Saturation Using Textile-integrated Polymer Optical Fibers -- Effect of Atorvastatin on Microcirculation Evaluated by Vascular Occlusion Test with Peripheral Near lnfrared Spectroscop -- Flow characteristics of the conjugate of anti-CD3 monoclonal antibodies and magnetic nanoparticle in the PBS and the blood vessel -- Cerebrovascular Reserve (CVR) and Stages of Hemodynamic Compromise -- On the mechanism of sustained mitochondrial membrane potential without functioning complex IV -- Further evidence that gradients of extracellular pH direct migration of MDA-MB-231 cells in vitro -- Blood Flow and Respiratory Gas Exchange in the Human Placenta at Term: A Data Update -- Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats -- Changes in Oxygenation Levels During Moderate Altitude Simulation (Hypoxia-Induced): A Pilot Study Investigating the Impact of Skin Pigmentation in Pulse Oximetry -- The Intramuscular Circulation is Affected by Neck and Shoulder Pain -- Intramuscular circulation of the lumbar multifidus in different trunk positions on standing -- Numerical Optimization of a NIRS Device for Monitoring Tissue Oxygen Saturation -- Upper trapezius muscle tonicity, assessed by palpation, relates to change in tissue oxygenation and structure as measured by Time-Domain Near Infrared Spectroscopy -- Perceived exertion correlates with multiple physiological parameters during cardiopulmonary exercise testing -- Systemic and Quadriceps Muscle O2 Dynamics in Subjects without Attenuation Point of Deoxygenated Hemoglobin Concentration during Ramp Cycling Exercise -- Jaw-Clenching Intensity Effects on Masseter Oxygen Dynamics and Fatigue: A NIRS Oximetry Study. .

Description / Table of Contents: Chapter 1. The historical studies underpinning the concept of hair follicle neogenesis (Higgins C, Jahoda C) -- Chapter 2. Hair regeneration and rejuvenation: pipeline of medical and technical strategies (Limbu S, Kemp P) -- Chapter 3. Cells and structures involved in hair follicle regeneration: an introduction (Tsai J, Garza LA) -- Chapter 4. The dermal papilla and hair follicle regeneration: Engineering strategies to improve dermal papilla inductivity (Pantelireis N, Clavel C) -- Chapter 5. Dermal sheath and hair follicle regeneration (Yoshida Y, Tsuboi K, Kishimoto J) -- Chapter 6. Epithelial-mesenchymal interactions between hair follicles and dermal adipose tissue (Ramos R, Plikus MV) -- Chapter 7. Lymphatic vasculature and hair follicle regeneration (Cazorla A, Perez-Moreno M) -- Chapter 8. In vitro and ex vivo hair follicle models to explore therapeutic options for hair regeneration (Bertolini M, Piccini I, McElwee KJ) -- Chapter 9. Extracellular vesicles including exosomes for hair follicle regeneration (Aberdam E, le Riche A, Bordes S, Closs B, Park BS, Aberdam D) -- Chapter 10. Stem cell-based therapies for hair loss: what is the evidence from a clinical perspective? (Park BS, Choi HI) -- Chapter 11. Induced pluripotent stem cell approach for hair follicle regeneration (Pinto A, Terskikh AV) -- Chapter 12. Biofabrication technologies in hair neoformation (Abreu CM, Gasperini L, Marques AP) -- Chapter 13. Wound healing induced hair follicle regeneration (Jiang Y, Myung P) -- Chapter 14. Hair follicles in wound healing and skin remodeling (Plotczyk M, Jimenez F) .

Description / Table of Contents: Part One: Basic Concepts in Precision Oncology -- Chapter 1. Design and Implementation of a precision oncology workflow -- Chapter 2. An overview of cancer genome sequencing -- Chapter 3. Software infrastructures for precision medicine workflows -- Part Two: Current Computational Methods and Tools in Precision Oncology -- Chapter 4. Somatic and germline variant calling from next-generation sequencing data -- Chapter 5. Identification of copy number alterations from next-generation sequencing data -- Chapter 6. Genome-wide discovery of large-scale structural variants from next-generation sequencing data -- Chapter 7. Assessment of microsatellite instability from next-generation sequencing data -- Chapter 8. Computational approaches for the investigation of intra-tumor heterogeneity and clonal evolution from bulk sequencing data -- Chapter 9. Analysis of the transcriptome for precision oncology applications -- Chapter 10. Computational methods for drug repurposing -- Chapter 11. Pathway for analysis for precision oncology applications -- Chapter 12. Identification of fusion transcripts from RNA-seq -- Chapter 13. Computational resources for the interpretation of variations in cancer -- Chapter 14. Analysis of electronic health records for precision oncology -- Chapter 15. Network approaches for precision oncology -- Chapter 16. Experimental validation of genomic alterations -- Part Three: Advanced Concepts - The Future of Precision Oncology -- Chapter 17. Molecular profiling of liquid biopsies for precision oncology -- Chapter 18. Artificial intelligence for precision oncology -- Chapter 19. Single-cell technologies in precision oncology -- Chapter 20. Computational approaches for precision immuno-oncology -- Chapter 21. Multi-pmics profiling of the tumor microenvironment -- Chapter 22. Epigenetic and precision oncology -- Chapter 23. Next generation knowledge bases to support precision oncology. .

Description / Table of Contents: Genetics control of immune responses -- Non-melanoma skin cancer -- Melanoma -- Psoriasis -- Atopic dermatitis -- Contact dermatitis -- Lichen planus -- Pemphigus and pemphigoids -- Morphea and Lichen Sclerosus -- Granuloma annulare and Necrobiosis lipoidica -- Alopecia areata -- Vitiligo -- Acne Vulgaris and Rosacea -- Urticaria and Angioedema -- Cutaneous drug reaction -- Photodermatologic disorders -- Infantile Haemangioma and other vascular malformations.

Description / Table of Contents: Chapter 1: Outline Of Anatomy/Physiology Of Skeletal Tissues -- Chapter 2: Tumors Of The Musculoskeletal System -- Chapter 3: Tumor-Like Lesions Of The Musculoskeletal System -- Chapter 4: General Considerations About Bone Tumors -- Chapter 5: Appendix: Manual For Histological Preparation And Examination Of Tissues Containing Bone And Cartilage.

Description / Table of Contents: Compliance with the Surgery Safety Checklist: An Update on the Status -- Surgical Safety Checklist: Polychromatic or Achromatic Design -- Surgical Strategy and Clinical Outcome in Patients with Bronchial Carcinoids -- Frozen Section or Intraoperative Cytology: Are We Ready for a Paradigm Shift in Thoracic Surgery? -- Clinical Outcome in Patients with Nosocomial COVID-19 Infection After Thoracic Surgery -- Cytological Diagnostic Procedures in Malignant Mesothelioma -- Combination of Biochemical and Cytological Findings for Better Diagnosis in Pleural Effusions -- Cytokines in Renal Cell Carcinoma: A Step Towards Earlier Detection and Targeted Therapy -- Primary Hyperparathyroidism Secondary to Ectopic Parathyroid Adenoma: A Case Report -- Perception of Well-Being and Quality of Life in Obese Patients After Bariatric Surgery -- Do Multiple Brain Lesions Always Connote Worse Outcomes? Appraisal Evidence from a Tertiary Care Center in Koshi/Purbanchal Province of Nepal -- Radioimaging and Demographic Profiles of Patients with Spontaneous Intracerebral Hemorrhage: A Need for the Pragmatic Referral System -- Anticytokine Treatment of Rheumatoid Arthritis: An Observational Report.

Description / Table of Contents: How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression -- Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression -- Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer -- Calcium-Permeable Channels in Tumor Vascularization: Peculiar Sensors of Microenvironmental Chemical and Physical Cues -- Circulating Tumor Cells: Does Ion Transport Contribute to Intravascular Survival, Adhesion, Extravasation, and Metastatic Organotropism?.

Description / Table of Contents: Part 1: Getting started -- Chapter 1: The why and the what of scientific research and publishing -- Chapter 2: Understanding research ethics -- Chapter 3: How to structure a scientific article, conference poster and presentation -- Part 2: The Hidden Bumps -- Chapter 4: Who gets authorship status? -- Chapter 5: The art of journal selection -- Chapter 6: Understanding the editor’s perspectives -- Part 3: The Destination -- Chapter 7: Converting a scientific article for the media -- Chapter 8: What are research metrics and why should I care? -- Chapter 9: Beyond your scientific publication -- Chapter 10: The Editor’s Perspective – Full-Length Interviews.

Description / Table of Contents: Artificial Intelligence and Precision Medicine: A Perspective -- Pedobarography in Physiotherapy: A Narrative Review on Current Knowledge -- Quantum Medicine: A Role of Extremely Low-Frequency Magnetic Fields in the Management of Chronic Pain -- Manual Therapy Approach to the Extraocular Muscles in Migraine Treatment: A Preliminary Study -- Capacitive and Resistive Electric Transfer Therapy: A Comparison of Operating Methods in Non-specific Chronic Low Back Pain -- Serum Impedance in Children with Recurrent Respiratory Infections -- Olfactory Response to Altitude Hypoxia: A Pilot Study During a Himalayan Trek -- The Impact of Change in Hospital Admissions When Primary Care Is Provided by a Single Primary Care Physician: A Cohort Study Among HMO Patients in Israel -- Risk of Falls in Patients Aged Over 65 in the Context of the Treatment Facility -- Anthropometric Indices as Long-Term Predictors of Diabetes in Impaired Fasting Glucose Metabolism: Findings in the PURE Study in Poland -- Cardiovascular Risk Factors Drive Impaired Fasting Glucose to Type 2 Diabetes: Findings After a 9-Year Follow-Up in the PURE Study in Poland -- Sleep-Disordered Breathing in Pregnancy.

Description / Table of Contents: Chapter 1. Creating Interactive Three-Dimensional Applications to Visualise Novel Stent Grafts That Aid in the Treatment of Aortic Aneurysms -- Chapter 2. Using Confocal Microscopy to Generate an Accurate Vascular Model for Use in Patient Education Animation -- Chapter 3. Methods and applications of 3D Patient-Specific Virtual Reconstructions in Surgery -- Chapter 4. Proof of Concept for the Use of Immersive Virtual Reality in Upper Limb Rehabilitation of Multiple Sclerosis Patients -- Chapter 5. Virtual Wards: A Rapid Adaptation to Clinical Attachments in MBChB During the COVID-19 Pandemic -- Chapter 6. Artificial Intelligence: Innovation to Assist in the Identification of Sono-anatomy for Ultrasound-Guided Regional Anaesthesia -- Chapter 7. A Systematic Review of Randomised Control Trials Evaluating the Efficacy and Safety of Open and Endoscopic Carpal Tunnel Release -- Chapter 8. Exploring Visualisation for Embryology Education: A Twenty-First-Century Perspective -- Chapter 9. How Artificial Intelligence and Machine Learning Is Assisting Us to Extract Meaning from Data on Bone Mechanics? -- Chapter 10. Visual Communication and Creative Processes Within the Primary Care Consultation -- Chapter 11. Digital 2D, 2.5D and 3D Methods for Adding Photo-Realistic Textures to 3D Facial Depictions of People from the Past -- Chapter 12. Teaching with Cadavers Outside of the Dissection Room Using Cadaveric Videos -- Chapter 13. A Novel Cadaveric Embalming Technique for Enhancing Visualisation of Human Anatomy -- Chapter 14. Assessing the Impact of Interactive Educational Videos and Screencasts Within Pre-clinical Microanatomy and Medical Physiology Teaching.

Description / Table of Contents: 1.Challenges of Stem Cell Therapies for the Treatment of Infertility in Reproductive Medicine -- 2.Regeneration of Human Ovaries Through Mesenchymal Stem Cell Transplantation Is Becoming a Reality -- 3.In Vitro Activation of Follicles for Treatment of Ovarian Insufficiency -- 4.Ovarian Cancer Stem Cells and their Regulatory Mechanisms: Potential Targets -- 5.Ovarian Cancer Stem Cells: Approach to Individualized Medicine -- 6.New Insights in Spermatogonial Stem Cells -- 7.Spermatogonial Stem Cell Cryopreservation for Fertility Preservation -- 8.Endometrial Stem Cells and Endometriosis -- 9.Pathogenesis of Endometriosis: Are Endometrial Stem/Progenitor Cells Involved? -- 10.Stem Cell Transplantation for Endometrial Regeneration in Humans -- 11.Germinal Origin of Very Small Embryonic-like Stem Cells (VSELs): Relation to Primordial Germ Cells -- 12.The Role of Very Small Embryonic-like Stem Cells (VSELs) in Reproductive Tissues -- 13.Amniotic Membrane: A Unique Combination of Stem-Like Cells and Extracellular Matrix with Indispensable Potential for Regenerative Medicine -- 14.Human Umbilical Cord Blood Mesenchymal Stem Cell Transplantation in Kidney Injury Animal Models: a Critical Review -- 15.Stem Cells in Human Breast Milk and Neonate.

Description / Table of Contents: 1. AI and Big Data for Intelligent Health: Promise and Potential -- 2. AI and Big Data for Cancer Segmentation, Detection and Prevention -- 3. Radiology, AI and Big Data: Challenges and Opportunities for Medical Imaging -- 4. Neuroradiology: Current Status and Future Prospects -- 5. Big Data and AI in Cardiac Imaging -- 6. Artificial Intelligence and Big data for COVID-19 Diagnosis -- 7. AI and Big Data for Drug Discovery -- 8. Blockchain of IoMT (BIoMT): A New Paradigm for COVID-19 Pandemic: Application, Architecture, Technology, and Security -- 9. AI and Big Data for Therapeutic Strategies in Psychiatry -- 10. Distributed Learning in Healthcare -- 11. Cybersecurity in Healthcare -- 12. Radiology and Radiomics: Towards oncology Prediction with IA and Big Data.

Description / Table of Contents: Chapter 1. Scaffolds for promoting neural repair -- Chapter 2. Composites for nerve regeneration -- Chapter 3. Configurable models of the blood-brain barrier -- Chapter 4. Engineering nerve conduits -- Chapter 5. Flexible electronics for stem cell differentiation -- Chapter 6. Nanosensors for brain chemistry -- Chapter 7. Nanomaterials for imaging the brain ECS -- Chapter 8. Microfluidics for analysis of neuronal development -- Chapter 9. Multiple particle tracking measurements of extracellular matrix dysregulation -- Chapter 10. Bioresponsive nanomaterials for treatment of CNS disease -- Chapter 11. Redox regulation for controlling cell fate -- Chapter 12. Polymersome delivery of CRISPR-based therapies -- Chapter 13. Multifunctional polymers for targeted delivery -- Chapter 14. Theranostic nanomaterials for brain injury.

Description / Table of Contents: Chapter 1. General Principles -- Chapter 2. Signals – Scattering -- Chapter 3. Signals - Fluorescence, Phosphorescence, Impedance, Extinction -- Chapter 4. Fluidics -- Chapter 5. Light Sources -- Chapter 6. Optical Benches -- Chapter 7. Detectors and Electronics -- Chapter 8. Signal Analysis -- Chapter 9. The Cytometric File -- Chapter 10. Data Transformation -- Chapter 11. Data Representation -- Chapter 12. Data Analysis -- Chapter 13. Standards, Setup, Calibration, and Control Techniques -- Chapter 14. Fluorochromes – Overview -- Chapter 15. Fluorochromes Suitable for Antibody Conjugation -- Chapter 16. Fluorochromes That Bind Nucleic Acids -- Chapter 17. Fluorochromes for the Study of the Cell Features -- Chapter 18. Fluorescent Proteins -- Chapter 19. Spillover and Compensation -- Chapter 20. Artifacts -- Chapter 21. Cell Sorting -- Chapter 22. Non-Conventional Flow Cytometry -- Chapter 23. Statistics: A Cytometric Point of View.

Description / Table of Contents: Chapter 1. The physical principles of light propagation and light-matter interactions -- Chapter 2. Design, alignment and usage of infinity-corrected microscope -- Chapter 3. Epifluorescence Microscopy -- Chapter 4. Basic digital image design, processing, analysis, management, and presentation -- Chapter 5. Confocal Microscopy -- Chapter 6. Live-cell Imaging: A Balancing Act Between Speed, Sensitivity and Resolution -- Chapter 7. Structured Illumination Microscopy -- Chapter 8. Stimulated Emission Depletion Microscopy -- Chapter 9. Two-Photon Imaging -- Chapter 10. Modern microscopy image analysis: quantifying colocalization on a mobile device -- Chapter 11. Spinning Disk Microscopy -- Chapter 12. Light Sheet Fluorescence Microscopy -- Chapter 13. Localization microscopy: a review of the progress in methods and applications.

Description / Table of Contents: The advent of Medical Biotechnology -- Biotechnology in Medicine: Fundamentals -- Biotechnology in Medicine: Advances-I -- Biotechnology in Medicine: Advances-II -- Analytical Techniques in Medical Biotechnology -- Immunology in Medical Biotechnology -- Epigenetics and Medical Biotechnology -- Stem Cell Technology in Medical Biotechnology -- Pharmaceutical Biotechnology -- Diagnostic and Therapeutic Biotechnology -- Nanotechnology and Nanomedicine -- Laboratory Protocols in Medical Biotechnology-I -- Laboratory Protocols in Medical Biotechnology-II -- Ethics and Medical Biotechnology -- Career and opportunities in Medical Biotechnology -- Index.

Description / Table of Contents: Epithelial Stem Cells: Making, Shaping and Breaking the Niche -- Parathyroid Cell Differentiation from Progenitor Cells and Stem Cells: Development, Molecular Mechanism, Function, and Tissue Engineering -- Regenerative Medicine Application of Mesenchymal Stem -- Identification of Small Molecules That Enhance the Expansion of Mesenchymal Stem Cells Originating from Bone Marrow -- Human-Induced Pluripotent Stem Cell-Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases -- Current Status, Barriers, and Future Directions for Humanized Mouse Models to Evaluate Stem Cell-Based Islet Cell Transplant -- Mesenchymal Stem Cell Therapy for Osteoarthritis: Practice and Possible Promises -- The Historical Relationship Between Meis1 and Leukemia -- An Overview of Zebrafish Modeling Methods in Drug Discovery and Development -- Cellular Stress Responses in Oocytes: Molecular Changes and Clinical Implications.

Description / Table of Contents: Introduction on Integrated Science: Multidisciplinarity and Interdisciplinarity in Health -- Cognitive Sciences as a Naturalistic Model of Interdisciplinary Approaches -- The Aesthetics of Science from the Viewpoint of Neuroscience -- Neuroscience and Quantum Physics Aspect of Human Brainwaves -- Modern Psychiatry: Confluence of Mind, Science, and Society -- Schizophrenia: A Disorder of Timing and Sensorimotor Integration during Decision-making -- Getting to Know Ourselves Through Recognizing Ourselves in Others: Neuroanatomy of Empathy in a Social Neuroscientific Model -- Why People Make Irrational Choices About Their Health? -- Adherence to Treatment: At the Interface of Biological, Medical, and Social Sciences -- Social Cognition and Food Decisions in Obesity -- Nuclear Medicine: A Transdisciplinary Field to Integrate Formal, Physical, Biological, and Medical Sciences -- Beyond the Borders of Dentistry: Interprofessional and Interdisciplinary Approach to Oral Health Promotion -- Drug Discovery in Big Pharma: Where “Birds” and “Fish” Collaborate to Find New Medicines -- A Phenomenological Analysis of the Pandemic: Philosophy and Life -- Engineering, Environment, and Health: Why interdisciplinarity matters? -- Super-spreading in Infectious Diseases: A Global Challenge for All Disciplines -- Possibility of Changes in Travel Behavior as a Consequence of the Pandemic and Teleworking -- Bringing the Two Cultures of the Arts and Sciences Together in Complex Health Interventions -- Thinking Deeper, Wider, Further: Visual Thinking for the Pandemic 3.0 and the Game-Changing Pathways ahead -- The Clinical Benefits of Art Therapy: Definition, History, and Outcomes with a Focus on Music Therapy -- When Combining Arts and Sciences Assists Medical Devices Uses: DeafSpace and Cochlear Implants -- Art, Medicine, and Public Health: Synergizing Humanistic and Medical Strategies in Managing a Pandemic -- Big Data and Artificial Intelligence for E-Health -- Artificial Intelligence in the Medical Context: Who Is the Agent in Charge? -- Ethical Deliberation on AI-Based Medicine -- Towards an Integrative and Holistic Approach to the Discipline of Health Informatics -- Integrated, Multidisciplinary, and Interdisciplinary Medical Education -- Giving Voice to Social Values in Achieving Universal Health Coverage -- Discrimination in Medical Research Sampling: Recommendations and Applications to Psychology -- Integrated Science 2050: Multidisciplinarity and Interdisciplinarity in Health.

Description / Table of Contents: Part 1. Regulatory.-1. Regulation of Cell Therapy in the United States.-2. Regulatory Landscape and Emerging Trends In Advanced Therapies Manufacturing: An EU Perspective.-3. Australian Cellular Therapy Regulations -- 4. Landscape for Regenerative Medicine Manufacturing in Japan -- 5. GLP Regulations for Non-clinical studies -- 6. Ethical Considerations in Cell Therapy -- 7. Investigational New Drug Applications for Cell Therapy Products -- 8. FDA Inspections -- 9. Commercialization of Investigational Cell Therapy Products -- Part 2 Quality Systems -- 10. The Meaning of Quality -- 11. Development and Maintenance of a Quality Program -- 12. Quality Control of Cellular Therapy Products and Viral Vectors -- 13. Quality Management Software – Q-Pulse -- 14. Selection of Contract Manufacturing and Testing Organizations -- Part 3 Facility Design -- 15. Introduction: Facility Design -- 16. PACT CPFs - Examples Describing Different Cell Processing Facility Designs -- 17. Design and Operation of a Multiuse GMP Facility at the City of Hope -- 18. Design and Operation of a Multiuse GMP Facility at the University of Miami -- 19. Design of a New Academic GMP Facility for Today and Beyond at the Dana-Farber Cancer Institute -- 20. Design and Licensure of an American Cord Blood Bank -- 21. Indiana University Vector Production Facility (IUVPF) -- 22. Qualification and Commissioning of a New GMP Facility -- Part 4 Facility Infrastructure -- 23. Environmental Monitoring -- 24. GMP Facility Cleaning and Maintenance -- 25. GMP Documentation -- 26. Process Validation -- 27. Equipment Qualification -- 28. Vendor Qualification and Supply Management -- 29. Staffing, Training and Competency -- Part 5 Product Management -- 30. Product Accessioning, Tracing and Tracking -- 31. ISBT 128 in Labeling of Cellular Therapy Products -- 32. Product Processing, Manufacturing and Administration -- 33. Transport and Shipment of Cellular and Gene Therapy Products -- 34. Regenerative Medicine: The Newest Cellular Therapy -- 35. Cellular Therapy Applications for COVID-19 -- Part 6 Professional Standards and Support Organizations -- 36. Professional Standards for Cellular Therapy: The Foundation for the Accreditation of Cellular Therapy (FACT) -- 37. AABB Cell Therapy Standards -- 38. USP Standards for Cell-based Therapies -- 39. The Role of the National Institute of Standards Measurement Assurance for Cell Therapies -- 40. National Science Foundation Engineering Research Center for Cell Manufacturing Technologies (CMaT) -- 41. Financial Considerations for Academic GMP Facilities -- 42. Governmental Support Opportunities for Cellular & Gene Therapies in the United States.

Description / Table of Contents: A Beginner’s Guide to Different Types of Microscopes -- Principles of Light and Fluorescence Microscopy -- Confocal and Multiphoton Microscopy -- Scanning Probe Microscopy: tipping the path towards atomic visions -- Atomic Force Microscopy - An Advanced Imaging Technique: From Molecules to Morphologies -- Exploring the microcosm at atomic precision using Atomic Force Microscopy -- Scanning Electron Microscopy (SEM): Learning to generate and interpret the topographical aspects of materials -- Recent updates on methods, applications, and practical uses of scanning electron microscopy in various life sciences -- Transmission electron microscopy - A powerful and novel scientific technique with nanoscale resolution for characterization of materials -- Preparation of Biological Samples for SEM: Techniques and Procedures -- Index.

Description / Table of Contents: 1. Introduction -- 2. Tracer technique in basic research -- 3. Tracer technique in applied research -- 4. Literature cited.

Description / Table of Contents: Preface (Claus Glüer) -- Chapter 1. Introduction (Quentin Grimal and Pascal Laugier) -- Part I: Ultrasound Methods for Skeletal Status Clinical Assessment -- Chapter 2. Quantitative Ultrasound (QUS) in the Management of Osteoporosis and Assessment of Fracture Risk: An Update (Didier Hans, Antoine Metrailler, Elena Gonzalez Rodriguez, Olivier Lamy, Enisa Shevroja) -- Chapter 3. Clinical devices for bone assessment (Kay Raum and Pascal Laugier) -- Chapter 4. Axial transmission – Techniques, devices and clinical results (Nicolas Bochud and Pascal Laugier) -- Chapter 5. Signal processing techniques applied to axial transmission ultrasound (Tho N.H.T. Tran, Kailiang Xu, Lawrence H. Le, and Dean Ta) -- Chapter 6. Ultrasonic Assessment of Cancellous Bone Based on the Two-Wave Phenomenon (Katsunori Mizuno, Yoshiki Nagatani, Isao Mano) -- Chapter 7. Pulse-echo Measurements of Bone Tissues. Techniques and Clinical Results at the Spine and Femur (Delia Ciardo, Paola Pisani, Francesco Conversano, Sergio Casciaro) -- Chapter 8. Scattering in Cancellous Bone (Keith Wear) -- Chapter 9. Ultrasound Scattering in Cortical Bone (Yasamin Karbalaeisadegh and Marie Muller) -- Chapter 10. Single-sided ultrasound imaging of the bone cortex: anatomy, tissue characterization and blood flow (Guillaume Renaud and Sébastien Salles) -- Chapter 11. Ultrasound Computed Tomography (Philippe Lasaygues, Luis Espinosa, Simon Bernard, Philippe Petit, Régine Guillermin) -- Part II: Ex vivo Measurement of Bone Material Properties: New Methods and Data -- Chapter 12. Measurement of Cortical Bone Elasticity Tensor with Resonant Ultrasound Spectroscopy (Simon Bernard, Xiran Cai and Quentin Grimal) -- Chapter 13. Documenting the anisotropic stiffness of hard tissues with resonant ultrasound spectroscopy (Xiran Cai, Simon Bernard, Quentin Grimal) -- Chapter 14. Assessing the elasticity of child cortical bone (Cécile Baron, Hélène Follet, Martine Pihioux, Cédric Payan, and Philippe Lasaygues) -- Chapter 15. Piezoelectric and Opto-Acoustic Material Properties of Bone (Atsushi Hosokawa and Mami Matsukawa) -- Part III: Emerging applications of Bone Quantitative Ultrasound -- Chapter 16. 3D Ultrasound Imaging of the Spine (Yong Ping Zheng and Timothy Tin Yan Lee) -- Chapter 17. Ultrasonic Evaluation of the Bone-Implant Interface (Yoann Hériveaux, Vu-Hieu Nguyen, Guillaume Haïat) -- Chapter 18. Adaptive ultrasound focusing through the cranial bone for non-invasive treatment of brain disorders (Thomas Bancel, Thomas Tiennot, Jean-François Aubry) -- Chapter 19. GuidedWaves in the Skull (Héctor Estrada and Daniel Razansky) -- Index.

Description / Table of Contents: 1 Introduction on Integrated Science: Transdisciplinary across the Different Disciplines -- 2 Chaos Theoretical Explanation to Each Development of Evolution Theory, Psychology, Physics, and Philosophy -- 3 Managerial Problems and Cultural Heritage in Information Technology -- 4 On the Essential Unity of Mathematics, Science, and Art: The Justice Evaluation Function and the Golden Number -- 5 Integration of Film Theory and Studies with Neuroscience -- 6 Systems View in Engineering Research -- 7 Molecular Dynamics Simulations: Concept, Methods, and Applications -- 8 The World Big Challenges Faced by Nanoscience: Examples of How Integrated Science Can Save the World -- 9 The Kaleidoscopic Image as an Intersection between Art and Science: From Microscopic Forms to Cosmological Models -- 10 Disruptions and Competitive Strategies in the Automotive Industry -- 11 Macroeconomics: From Equilibrium Settings to Multi-Agent Worlds -- 12 A Multi-level Perspective to Biosimilars Development: Pathways Towards Incremental Innovation in the Health Bioeconomy -- 13 A 2020s Marketing Taxonomy for Augmented Reality Customer Experience -- 14 Can Viral Marketing Content Spread according to the Rumour Formula? -- 15 Exaptation as a Design Strategy for Resilient Communities -- 16 Ecosystem management and climate-smart agriculture -- 17 A new generation of shrimp aquaculture for sustainability and resilience of future green cities -- 18 Public Understanding of Geoethics Dilemmas: A Case Study on Lithium Exploitation -- 19 Creative Approaches for Mitigating Environmental Challenges: A Cosmopolitan Localism Perspective -- 20 Landscape: A Holistic Approach to Space -- 21 Integrated Approaches to Land Management -- 22 Archaeology as an Interdisciplinary Science at the Cross-Roads of Physical, Chemical, Biological, and Social Sciences: New Perspectives and Research -- 23 Biomimicry in Architecture: From Theory to Practice -- 24 Ecodemocracy in Practice: Examples of Forestry and Food Production -- 25 Semantic Analyses of Hilary Putnam’s Twin Earth (ft. TE Diagram) -- 26 Sport Sciences: An Ideal Field of Play for Integrated Knowledges -- 27 Single Valued Neutrosophic Set: An Overview -- 28 Technology Assessment Integrated research for scientific policy advice -- 29 The Artistic and Scientific Nature of Protein Structure: A Historical Overview -- 30 The Art and Science of Biomimicry – Abstracting Design Principles from Nature -- 31 The Phenomenon of Meeting in Art: A Transdisciplinary Approach -- 32 The Phenomenon of Meeting in Art: A Transdisciplinary Approach.

Description / Table of Contents: Cell and Molecular Biology of Centrosome Structure and Function -- The centrosome Cycle within the cell cycle -- Centrosome as center for proteolytic activity and dysfunctions associated with pathogenesis of human disease -- Centrosome dysfunctions in cancer -- Virus exploitation of centrosomes -- Centrosomes in reproduction -- Transition from centrosomal to non-centrosomal microtubule organization during cellular polarization -- External and environmental effects on Centrosomes -- Centrosomes and centrosome equivalents in other systems -- Non-centrosomal microtubule organization in plant cells.

Description / Table of Contents: 1. Introduction -- Part I Transforming Research with Broad Engagement -- 2. The Transformative Power of Broadly Engaged Team Science: A Moth-er’s Quest to Understand PXE -- 3. Broadly Engaged Team Science in Neonatal Research -- 4. Patient Advocates in Cancer Care: A Rich Tradition and Evolving Role -- 5. National Kidney Foundation Patient Network -- 6. Broadly Engaged Team Science Comes to Life in a Design Lab -- 7. Tufts Center for the Study of Drug Development Employs Broadly Engaged Team Science to Explore the Challenges of Pharmaceutical Research and Development -- Part II. Integrating Communities and Stakeholders into Broadly Engaged Team Science -- 8. Social Movements and Stakeholder Engagement -- 9. A Basic Scientist’s Journey: Engaging Public Stakeholders Through Civic Science -- 10. Lessons in Public Involvement from Across the Pond -- 11. Leveling the Playing Field for Community Stakeholders: Examining Practices to Improve Engagement and Address Power Dynamics -- 12. A Theory of Stakeholder-driven Community Diffusion -- 13. Monitoring and Evaluation of Stakeholder Engagement in Health Research -- Part III. Applying Broadly Engaged Team Science: Case Studies -- 14. Insiders and Outsiders: A Case Study of Fostering Research Partnerships between Academic Health Centers and Corrections Institutions -- 15. Responding to the Community: HOPE (Healthy Outcomes from Positive Experiences) -- 16. Students as Key Collaborators in Tackling Early Stage Research Ideas -- 17. Engaging Stakeholders to Decrease Study Start-up Delays -- 18. Health Literacy and Broadly Engaged Team Science: How One Study Team Used Plain Language Principles to Share Findings with Affected Communities -- 19. Utilizing Patient Navigators to Promote Equitable and Accountable Research -- 20. Asian American Research in the Post-Atlanta Era: Driving Community-engaged Research That Is More Meaningful, Responsive, and Actionable for Local Communities -- 21. Stakeholder Engagement in Predictive Model Development for Clinical Decision Support -- Part IV. Creating an Institutional Environment of Support for Broadly Engaged Team Science -- 22. Research Administration Practices for Proposal Development and Post-Award Management of Stakeholders and Community Participants -- 23. Starting Off Right: Supporting Community Involvement in the Evaluation of Research Proposals -- 24. Role of Broadly Engaged Team Science in the Inclusion of Minority Populations as Research Participants and in All Roles on Research Teams -- 25. Rewarding Team Science in Tenure and Promotion Practices: An Operational Imperative for the Academic Research Enterprise of the 21st Century -- Epilogue.

Description / Table of Contents: A Protein-centric Perspective of Autophagy and Apoptosis Signaling and Crosstalk in Health and Disease -- Adrenergic receptor signaling pathways in the regulation of apoptosis -- Apoptosis in Ischemic Heart Disease -- Autophagy in cardiac physiology and pathology -- Caspase signaling pathways as convenors of stress adaptation -- Cross talk between apoptosis and autophagy in regulating the progression of heart disease -- Fibroblasts, Fibrosis and Autophagy -- Gene Therapy and Its Application In Cardiac Diseases -- Inflammation and mitochondrial degradation in the heart -- Mitochondria and Cellular Hosts_An Uneasy Truce -- Mitochondrial Dysfunction and Mitophagy -- Proteotoxicity and Autophagy in Neurodegenerative and Cardiovascular Diseases -- Regulation of Cell Death Signaling Pathways in Cardiac Myocytes by Mitochondrial Bnip3 – Inna -- Role of Cardiomyocyte Apoptosis in Heart Failure -- The Role of FGF2 Isoforms In Cell Survival In The Heart.

Description / Table of Contents: Discovery and Overview of Par-4 -- Par-4 in cell cycle regulation -- Conformational studies of the Par-4 C-terminal Domain -- Structural analysis of Par-4 and crystallographic analysis of the regulatory domain -- Regulation of Par-4 by Ubiquitinases -- REGULATION OF PAR-4 FUNCTION BY PHOSPHORYLATION -- Role of Par-4 in GRP78 translocation -- PAR-4 in the regulation of stem cell death and embryo development -- RASSF2 and the PAR-4 connection -- Regulation of tumor suppressor Par-4 by ceramide -- PAWR as a direct SRC-1/HOXC11 suppression target -- Index.

Description / Table of Contents: 1. Epithelial-mesenchymal transition and cancer stem cells -- 2. The transcription factors Zeb1 and Snail induce cell malignancy and can-cer stem cell phenotype in prostate cells, increasing androgen synthesis ca-pacity and therapy resistance -- 3. ERBB signaling pathway in cancer stem cells -- 4. Functional and molecular characters of cancer stem cells through devel-opment to establishment -- 5. Microenvironment in cancer stem cells -- 6. Cancer stem cells contribute to drug resistance in multiple different ways -- 7. Abnormal glycosylation in cancer cells and cancer stem cells as a thera-peutic target.

Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.

Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.

Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.

Description / Table of Contents: Part I: An overview of cancer and its mechanisms -- 1-A brief overview of cancer, its mechanisms, and prevention methods -- 2-MECHANISMS INVOLVED IN CARCINOGENESIS -- Part II: Functional foods/nutraceuticals as chemo preventive agents -- 3-Tomato (lycopene and β-carotene) and cancer -- 4-Essential Oils from Aromatic Plants in cancer prevention and treatment -- 5-Bee propolis (caffeic acid phenethyl ester) against cancer -- 6-Brown Algae (Fucoxanthin) Against Cancer -- 7-Cruciferous vegetables (indole-3-carbinol, isothiocyanates) against cancer -- 8-Crustacea (carotenoids namely astaxanthins) against cancer -- 9-Curcuma and breast cancer: a focus on cell signaling pathways -- 10-FRUITS AND VEGETABLES IN CANCER -- 11-Garlic: Allyl Sulfur Compounds and Cancer Prevention -- 12-Ginger (gingerols and 6-shogaol) against cancer -- 13-Saffron (crocins) against cancer -- 14-OLIVE LEAF (OLEUROPEIN) AND ITS ROLE IN CANCER: THERAPEUTIC UPDATES -- 15-Honey against cancer -- 16-Soybeans and phytoestrogen rich foods (genistein, daidzein) against cancer -- 17-Tea (catechins including (-)-epigallocatechin-3-gallate) and cancer -- 18-Probiotics and Cancer -- Part III: The role of nutrients in the prevention of cancer -- 19-Vitamins (C, D and E) against cancer -- 20-Minerals (namely selenium) and cancer -- 21-Dietary fibers/beta-glucan and cancer -- 22-Omega-3 Polyunsaturated Fatty Acids and Cancer.

Description / Table of Contents: Ch 1: Overview of Microbial NGS -- Ch 2: WGS for Bacterial Identification and Susceptibility Testing -- Ch 3: WGS for Bacterial Virulence Assessment -- Ch 4: Epidemiological Typing by WGS -- Ch 5: Bioinformatics Approaches for WGS Analysis -- Ch 6: WGS for Clinical Virology -- Ch 7: WGS for Clinical Mycology -- Ch 8: WGS for Clinical Parasitology -- Ch 9: Long Read Sequencing -- Ch 10: Aspects of WGS Integration -- Ch 11: Microbiome Analysis -- Ch 12: Metagenomics of Environmental Samples -- Ch 13: Clinical Metagenomics -- Ch 14: Metagenomics for Pathogen Discovery -- Ch 15: Advanced Applications for MALDI-TOF: Typing -- Ch 16: Advanced Applications for MALDI-TOF: Infectious Diseases and Antibiotic Susceptibility Testing (AST) -- Ch 17: Omics for Food and Water Microbiology -- Ch 18: Omics for Forensic and Post-Mortem Microbiology -- Ch 19: Omics for Antimicrobial Resistance Surveillance -- Ch 20: Total Laboratory Automation.

Description / Table of Contents: Graviola Fruit Extraction by Ionic Liquid Microwave-assisted Extraction (IL-MAE) -- Role of Ionic Liquids in the Enzyme Stabilization: A Case Study with Trichoderma ressie Cellulase -- Role of Ionic Liquids in the Processing of Lignocellulosic Biomass -- Proliferation of rat amniotic stem cell (AFSC) on modified surface microcarrier -- Application of spectroscopic methods for the analysis of non-halal meats in food products: A narrative review -- Identification of Potential Biomarkers of Porcine Gelatin -- Gamma Ray Mutagenesis on Bacteria Isolated from Shrimp Farm Mud for Microbial Fuel Cell Enhancement and Degradation of Organic Waste -- Effect of temperature on antibacterial activity and fatty acid methyl esters of Carica papaya seed extract -- Solid-state Fermentation of Agro-industrial Waste Using Heterofermentative Lacti Acid Bacteria -- Synthesis of chitosan-folic acid nanoparticles as a drug delivery system for propolis compounds.

Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Bioreceptors -- Chapter 3. Catalytic Biosensors -- Chapter 4. Affinity Biosensors -- Chapter 5. Affinity Biosensors -- Chapter 6. Label-free Biosensors -- Chapter 7. Bioreceptor Immobilization -- Chapter 8. Biochips. Chapter 9. Genome Sequencing -- Chapter 10. Genome Sequencing -- Chapter 11. Micro Electrode Arrays, Implants and Organs-on-a-Chip -- Appendix.

Description / Table of Contents: Basic structure, physiology and biochemistry of connective tissues and extracellular matrix collagens -- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life -- Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins -- Proteoglycans and Diseases of Soft Tissues -- Growth Factor Roles in Soft Tissue Physiology and Pathophysiology -- Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling -- The Pathophysiology and Pathogenesis of Marfan Syndrome -- Ehlers-Danlos syndromes, joint hypermobility and hypermobility spectrum disorders -- Ehlers–Danlos Syndrome Associated with Glycosaminoglycan Abnormalities -- Loeys-Dietz Syndrome -- Meester-Loeys syndrome -- Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Elastic Fiber Homeostasis -- Collagen VI Muscle Disorders: Mutation Types, Pathogenic Mechanisms and Approaches to Therapy -- Connective Tissue Disorders in Domestic Animals.

Description / Table of Contents: Clinical features, diagnostic evaluation and management of COVID-19 patients -- Outbreak of COVID-19: A Detailed Overview and Its Consequences -- A paradigm gap in host-pathogen interaction studies: Lesson from the COVID-19 pandemic -- SARS/CoV-2: Behavioral Host Manipulation -- Management of COVID-19 in the Intensive Care Unit -- First wave of Covid-19 pandemic in Italy: data and evidence -- Risk factors for COVID-19: diabetes, hypertension and obesity -- Current challenges for the effective management of the COVID-19 pandemic -- COVID-19 Outbreak Challenges in Indian Migrant Pregnant and Lactating Mothers: Learnt Lesson Demands Phronesis and Hierarchical Strategies for Such Future Pandemics -- COVID-19 and Extracorporeal Membrane Oxygenation -- COVID-19's Clinical-Pathological Evidence in Relation to its Repercussion on the Central and Peripheral Nervous System -- Anatomopathological Aspects and Clinical Correlation of COVID-19: A Systematic Review -- SARS-CoV-2 liability: the hidden mystery behind its presentation in children.

Description / Table of Contents: Origin and structural biology of Novel Coronavirus (SARS-CoV-2) -- The Molecular Virology of Coronaviruses with Special Reference to SARS-CoV-2 -- Epidemiology, transmission and molecular immunopathology of SARS-CoV-2 -- Epidemiology and Etiopathogeny of Covid-19 -- Immunological and Hematological Response in COVID-19 -- Toll-like receptors (TLRs) as Therapeutic Targets for Treating SARS-CoV-2: An Immunobiological Perspective -- Potential drug strategies to target Coronaviruses -- Possible therapeutic intervention strategies for COVID-19 by manipulating the cellular proteostasis network -- The potential impact of statins in the treatment of patients with COVID-19 infection -- Anticoronavirus activity of water-soluble pristine C60 fullerenes: in vitro and in silico screening -- Application of Nanoscale materials and nanotechnology against viral infection: A special focus on Coronaviruses -- Obesity: A Risk Factor for Covid-19 -- Cytokine Storm and Failed Resolution in COVID-19: Taking Cue from Multiple Sclerosis.

Description / Table of Contents: Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy -- Chaperonin Hsp60 and Cancer Therapies -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics -- Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- Heat Shock Proteins in Atrial Fibrillation -- Threading Microarrays into Novel Applications -- Regulation of Kaposi’s Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones -- Role of Heat Shock Factors in Diseases and Immunity -- Heat Shock Proteins and Pain -- Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions -- Roles of Heat Shock Proteins on Antigen Presentation -- Heat shock proteins mediate anastasis and plasticity of thermotolerant cells.

Description / Table of Contents: Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers -- Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications -- Metal-organic Framework—Polymer Mixed-Matrix Membranes -- Insights into Adaptive Selforganized Supramolecular Structures from Molecular Modeling and Visualization -- Self-Assembled Metallacages as Drug Delivery Systems: Design Concepts and Challenge -- Functional Microporous Polymer Networks: Synthesis and Applications -- A Story on Carbon Dioxide and its Hydration -- Inverse Design and Hierarchical Multiscale Modelling of Biological Matter -- DNA-Directed Self-assembly of Macromolecular Structures -- Luminescent Complexes and their Assemblies : from Understanding to Artificial Virus -- Tailor-Made Polymers and Nanoparticles for Applications in Nanomedicine -- Squalene-based Nanomedicines : An Original and Efficient Approach for the Treatment of Neurological Disorders without Crossing the Blood-Brain Barrier -- Biodegradable Nanoparticles for Specific Drug Transport -- Multivalent rotaxanes designed as antibiofilm agents -- Measuring Ionic Transport through Lipid Bilayers -- Polymeric Carriers for Transporting Nucleic Acids - Contributions to the Field -- Smart Polymeric Materials for Drug Delivery -- Supramolecular Guanosine-quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications -- Hydrogelation of Chitosan with Monoaldehydes towards Biomaterials with Tuned Properties -- Inorganic Nanoarticles as Free Radical Scavengers -- A Microbiological Epilogue - Nosocomial Infections -- Molecular Dynamic Simulations and In Silico Analysis of Supramolecular Self-Assembled Structures -- Validation of the Non Toxicity of Non Viral Genetic -- Kinetics Transport of Ions/Water Through Nano-Scale Channels : Review And Update.

Description / Table of Contents: 1-Dimensional Convolution Neural Network Classification Technique for Gene Expression Data -- Classification of Sequences with Deep Artificial Neural Networks: Representation and Architectural Issues -- A Deep Learning Model for MicroRNA-Target Binding -- Recurrent Neural Networks Architectures for Accidental Fall Detection on Wearable Embedded Devices -- Medical Image Retrieval System using Deep Learning Techniques -- Medical Image Fusion using Deep Learning -- Deep Learning for Histopathological Image Analysis -- Innovative Deep Learning Approach for Biomedical Data Instantiation and Visualization -- Convolutional Neural Networks in Advanced Biomedical Imaging Applications -- Deep Learning for Lung Disease Detection from Chest X-Rays Images -- Deep Learning in Multi-Omics Data Integration in Cancer Diagnostic -- Using Deep Learning with Canadian Primary Care Data for Disease Diagnosis -- Brain Tumor Segmentation and Surveillance with Deep Artificial Neural Networks.

Description / Table of Contents: Section I – Introduction to Spermatology Symposium -- Chapter 1. The XIIIth International Symposium on Spermatology -- Chapter 2. Fifty Years of the Spermatology Symposium -- Chapter 3. Spermatology in Sweden -- Section II – Are Sperm at the Verge of Extinction? -- Chapter 4. Temporal trends in human sperm counts: Findings and implications -- `Chapter 5. Is Decreasing Sperm Concentrations a Sign of a General Decay in Fertility Potential? -- Chapter 6. Environmental toxicants and sperm production in men and animals -- Section III – Sperm DNA – protection and delivery of a complete and undamaged genome? -- Chapter 7. Post-testicular sperm DNA oxidation: what to be afraid of? -- Chapter 8. Sperm as a possible source of transgenerational epimutations and genetic instability -- Chapter 9. Complex population of chromatin-associated proteins identified in mature sperm of the European sea bass (Dicentrarchuslabrax) through high-throughput proteomic analysis -- Chapter 10. Does Cinnamtannin B-1 protects or destabilize sperm DNA? Contradictory results of SCSA® and TUNEL Invited presentations -- Chapter 11. Peripubertal serum dioxin concentrations and sperm methylome of young Russian adults -- Chapter 12. Sperm DNA fragmentation in human split ejaculates -- Section IV - Sperm Competition, Evolution and Sperm-Egg Interaction -- Chapter 13. The sexual cascade: evolutionary dynamics of sperm competition -- Chapter 14. Genotype-phenotype associations in relation to evolution of sperm form and function -- Chapter 15. From mouse to human: New aspects of sperm transport and fertilization using cutting edge technologies -- Chapter 16. First Snapshot of How Sperm Binds the Egg at the Molecular Level -- Chapter 17. The Typical and Atypical Centrioles and Their Potential Roles in the Sperm and Embryo -- Chapter 18. Adaptive modifications of the regulation of sperm motility in the diversification of reproductive modes of amphibians -- Section V - Genetic aspects of sperm production and performance and its effects on the offspring -- Chapter 19. When cilia go bad - the complex genetics of ciliopathies -- Chapter 20. Within-Ejaculate Sperm Selection and its Implications for Assisted Reproduction Technologies -- Chapter 21. Requirements for informative and robust computational measures of sperm motility -- Chapter 22. Effect of cryopreservation on the genome of sperm in animal and humans -- Chapter 23. Mutations in the CFAP-coding Genes Lead to Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella -- Chapter 24. The mouse-specific Gly-to-Cys mutation in mammalian acrosin is a cause of impairment in proteolytic activity -- Chapter 25. Chemical and genetic approaches to identify C. elegans spermiogenesis-related factors -- Section V -CASA - Advances and Challenges -- Chapter 26. CASA in the clinical andrology laboratory -- Chapter 27. Process and Data Management of Casa in Animal Spermatozoa -- Chapter 28. Relationship between flagellar movement and head trajectory at higher frame rates-is this still a valid approach for CASA? -- Chapter 29. CASA a Suitable tool for epidemiology and reprotox studies -- Section VI -Challenges for Sperm Function In Vitro -- Chapter 30. Common challenges for sperm in vitro- causes and consequences -- Chapter 31. Main effects of in vitro manipulation of spermatozoa -- Chapter 32. Effect of Melatonin on Capacitation and Ca2+ Distribution in Red Deer Spermatozoa -- Chapter 33. Unravelling the signal transduction pathways of novel mitochondrial peroxiporins in activated piscine spermatozoa -- Chapter 34. Prolonged chilled preservation and preliminary investigations of energy production of koala (Phascolarctos cinereus) spermatozoa -- Chapter 35. Sperm motion and metabolism in physiological conditions -- Chapter 36. Gametes collision in fresh water fish: evidences of guidance and selection -- Chapter 37. Lectin-binding pattern changes on the bovine sperm after differently induced process of capacitation -- Section VII -Heterogeneity of Sperm Morphology and Laboratory Techniques to Overcome Assessment Challenges -- Chapter 38. Have we conquered sperm morphology analysis in different mammalian species as analysed by CASMA? -- Chapter 39. Progress with sperm morphology evaluation after the strict criteria prognosis groups era due to the introduction of the new lower reference limit values for semen parameters of the 2010 WHO manual -- Chapter 40. A structured assessment for the assessment of human sperm morphology -- Chapter 41. On the Indispensability for Standardization of the Basic Examination of Human Semen -- Chapter 42. A simple but dramatic technical improvement in the Diff Quik stain protocol used for preparing specimens for sperm morphology evaluation (Improved Diff Quik stain protocol for preparation of sperm morphology evaluation specimens) -- Section VII - Fertility and Infertility -- Chapter 43. Intracellular Viruses Identification in Sperm Assay of Patients with Fertility problems -- Chapter 44. Association between vitamin D intake and vitamin D status with semen parameters among young men in Southern Spain -- Chapter 45. Single cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success -- Chapter 46. Sperm from a patient with a homozygous in-frame deletion in CATSPERE lack functional CatSper expression and fail to fertilise at IVF -- Chapter 47. Changes in pattern of protein phosphorylation in bull testicular and epididymal sperm -- Chapter 48. Proteomics and biomarker identification in improved sperm motility parameters after 4 h of ejaculatory abstinence -- Chapter 49. HSP90A may control spermatogenesis of Asian elephant (Elephas maximus) cryptorchid testes -- Chapter 50. Improved sperm function in human sperm subpopulations: a model for studying subfertility -- Chapter 51. Absence of BSP protein have not important effect on male infertility. .

Description / Table of Contents: Overload of Medical Documentation: A Disincentive for Healthcare Professionals -- Epidemiologic Benefits of Pneumococcal Vaccine Introduction into Preventive Vaccination Programs -- Serum Vitamin D and Immunogenicity of Influenza Vaccination in the Elderly -- Influenza A (H1N1) and Respiratory Syncytial Virus (RSV) Coinfection in a Newborn Child: A Case Report -- Thoracic Manifestation of Granulomatosis with Polyangiitis: A Case Report -- The Natural Course of Impaired Fasting Glucose -- Oleosins: A Short Allergy Review -- Shortage of Physicians: A Critical Review -- Fluid Therapy in Patients Undergoing Abdominal Surgery: A Bumpy Road Towards Individualized Management -- Manual Pressure Release and Low-Grade Electrical Peripheral Receptor Stimulation in Nonspecific Low Back Pain: A Randomized Controlled Trial -- Human Inhalation Study with Zinc Oxide: Analysis of Zinc Levels and Biomarkers in Exhaled Breath Condensate. Cognitive Function After Lung Transplantation.

Description / Table of Contents: Foreword -- Ferroptosis: Concepts and Definitions -- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors -- Iron Homeostasis and Metabolism: Two Sides of a Coin -- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis -- Emerging Role for Ferroptosis in Infectious Diseases -- Small Molecule Regulators of Ferroptosis -- Necroptosis, The other main Caspase-Independent Cell Death.

Description / Table of Contents: Constituents of Cannabis Sativa -- Synthetic and Natural Derivatives of Cannabidiol -- Clinical Pharmacokinetics of Cannabinoids and Potential Drug-Drug Interactions -- Cannabinoid Receptors and Ligands: Lessions from CNS Disorders and the Quest for Novel Treatment Venues -- Sleep-Wake Neurobiology -- Cannabinoids and Sleep/Wake Control -- Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals -- Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence -- Natural Cannabinoids as Templates for Sleep Disturbances Treatment -- The Effect of Cannabinoids on the Brain´s Circadian Clock -- Effects of Cannabis Consumption on Sleep -- Addiction and Sleep Disorders -- Cannabis for Restless Legs Syndrome.

Description / Table of Contents: Introduction on Integrated Science: Science without Borders -- The Human Person as an Integrated System -- On the Nature of Qualitative Research in Process Transformations: The Changing Man in the Changing World.-Integrated Science: Ambitions, Practicalities, Misunderstandings -- The Integration of the Sciences and Integral Human Knowledge -- The Indelible Stamp of Lowly Origins: An Epistemic Architecture between the Sciences and Humanities -- Transdisciplinary Science: Integration or Systematic, Strategic and Catalytic Knowledge -- Models and Integration -- Unlaws: the Missing “Dark Matter” in the Philosophy of Science -- Life - Stabilization of the Unstable through Controlling Influence of Quantum Information -- The Sustainable Humanist Concept in Art and Science Synergies -- From Being One to Being Many. Understanding the Diversity of Bio‐Life: Human, Nonhuman and Liminal Beings in the in Bio Art and Body Art -- Composite Bodies in Times of Catastrophe. On Socio‐Material Assemblies, Affective Contagions and the Biodegradable -- Life, Complexity, Communication: Integrating Social Systems Theory and Consciousness -- Rethinking the Reverse Side of Artificial Intelligence -- The Question of Transdisciplinarity between Modern Science and Critical Thought -- Adaptive Networks at the Crossroad of Artificial Intelligence and Formal, Biological, Medical and Social Sciences -- Are We Ready for "Them" Now? The Relationship between Human and Humanoid Robots -- Integrating Computer Simulation and Social Theory for Planning and Managing Complex Problems -- Rethinking Managerial Control in the Contemporary Context -- Innovation and Altruism: A New Paradigm Defining the Survival of Corporations -- Integrated Science 2050: Science without Borders.

Description / Table of Contents: The Origin of Eukaryotic Cells and Multicellular Organisms -- Multicellular Organisms Propagation -- Grow Fast and Well or Die -- Why Do Animals Grow, Age and then Die? -- How Do Tissues Regenerate After an Injury? Epilog. The Future of Humankind Could Depend on Unicellular Life.

Description / Table of Contents: Chapter 1: “Carving Your Own Path” – shaping your scientific identity -- Chapter 2: The Two Cornerstones of Academic Research: Writing Grant Applications and Publications -- Chapter 3: Setting up a Successful Research Group -- Chapter 4: Leading Your Research Group as a Principal Investigator -- Chapter 5: The Daily Work of Principal Investigators -- Chapter 6: Dealing with Failure and Stress in Academic Research -- Chapter 7: Thoughts of Principal Investigators about Work, Science, and Themselves -- Chapter 8: Under the Hood – Common Thinking Patterns of Principal Investigators -- Chapter 9: Epilogue -- Chapter 10: Methods.

Description / Table of Contents: Recent Advances in the Generation of β-cells from Induced Pluripotent Stem Cells As a Potential Cure for Diabetes Mellitus -- Differentiated cells derived from hematopoietic stem cells and their applications in translational medicine -- Organoids in Tissue Transplantation -- Aldo keto reductases AKR1B1 and AKR1B10 in cancer: molecular mechanisms and signaling networks -- Bilayer Scaffolds for Interface Tissue Engineering and regenerative medicine: A Systematic Review -- Pluripotent Stem Cell Derived Neurons as In Vitro Models for Studying Autosomal Recessive Parkinson’s Disease (ARPD): PLA2G6 and Other Gene Loci -- Stem Cell Applications In Lysosomal Storage Disorders: Progress And Ongoing Challenges -- Mechanisms of Drug Resistance and Use of Nanoparticle Delivery to Overcome Resistance in Breast Cancers -- Telomere length and oxidative stress in patients with St-elevation and Non-St-elevation myocardial infarction -- Eosinophils as major player in Type 2 inflammation: autoimmunity and beyond.