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  • Books  (6)
  • Biology Research.  (6)
  • Biomedical Research.  (6)
  • Cham :Springer International Publishing :  (6)
  • KIT Scientific Publishing
  • 570.28  (3)
  • 573.1  (3)
  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cardiovascular system. ; Physiology. ; Cardiology. ; Medicine Research. ; Biology Research. ; Medical sciences. ; Health. ; Sex. ; Cardiovascular Physiology. ; Cardiology. ; Biomedical Research. ; Health Sciences. ; Gender and Health.
    Description / Table of Contents: Attenuation of Bnip3 Mediated Doxorubicin-Induced Cell Death in Cardiac Myocytes -- Sex Dependent Regulation of Circadian Rhythms in Health and Disease -- Circadian Pharmacological Approach to Treat Myocardial Infarct -- GPER Function as a Determinant of the Progression of Atherosclerotic Disease in Women -- Novel Therapeutic Approach to Treat Cardiac-Rheumatology in Females -- Correlation between Sex, Immigration Status, Ethnicity, and Long-term Outcomes of Ischemic Stroke -- Risk Assessment and Predictive Modelling for The Heart-Brain Interface in Women -- Insomnia Interventions for Female Cardiac Patients -- Aortic Stenosis Progression, Cardiac Damage, and Survival: Comparison Between Men and Women -- Treatment and Management of Valvular Heart Disease and Cost-Effectiveness Analysis -- Association of Mortality and Acute Aortic Events with Ascending Aortic Aneurysm -- Improving Diagnosis and Treatment for Patients Who Suffer Spontaneous Coronary Artery Dissection (SCAD) -- Preeclampsia and Future Cardiovascular Health -- Cardiovascular Disease in Women with a History of Pregnancy Complications -- Hormone Replacement Treatment for Cardiovascular Disease -- Cardiovascular Mortality Following Early-Stage Breast Cancer -- Lipid Management for the Prevention of Atherosclerotic Cardiovascular Disease in Women -- Sex Differences in Cardiac Rehabilitation Enrollment -- Promoting Exercise and Physical Activity in Female Patients with Heart Disease -- Sex and Gender Differences in the Diagnosis, Treatment, and Outcomes of Coronary Artery Disease -- Sex Differences in Arterial Aging and its Implications on Cardiovascular Diseases -- Impact of a Novel Community-Based Lifestyle Intervention Program on Type 2 Diabetes and Cardiovascular Risk -- Clinical Outcomes Related to Heart Failure and Pulmonary Hypertension -- Examination of Health-Related Quality of Life in Women with Coronary Artery Disease -- The Risks and Benefits of Implantable Cardioverter-Defibrillator Generator Replacement -- The Effects and Roles of Estrogen in Managing Hypertension in Menopausal Women -- The Effects of Menopausal Hormone Therapy on the Vascular System -- Influence of Sex Differences in Non-Obstructive Coronary Artery Disease -- Diet1 and Resistance to High Cholesterol Levels and Cardiovascular Disease -- Interventions to Improve Clinical Outcomes Following Hospitalization for Heart Failure -- Sex-Dependent Cardioprotective Effects of the Phytoestrogen Resveratrol -- Blood Pressure Across a Woman's Life Cycle -- Women’s Fitness Levels and Heart Rate Response to Exercise -- Supervised Exercise Therapy Through Cardiac Rehabilitation following Peripheral Arterial Disease -- Sex Differences in ANT2-Mediated ATP Import into Mitochondria for Protection Against Hypoxia Lethal Injury.
    Abstract: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in women and men worldwide and represents a major financial burden to world health care systems. Importantly, CVD has eclipsed cancer as the leading cause of death for women globally. Through advancements in research and clinical testing, the symptoms and risk factors for CVD have been well established for men, but not for women. Consequently, there is an immediate need for new innovative research that will bridge this gap and allow for improved early diagnosis and treatment of CVD in women. This book will serve as a guide for health care providers to better understand the physiological, biochemical, and genetic differences in heart disease in women with the goal of providing improved education, awareness and treatment of cardiovascular disease in women. The book will cover topics such as: sex dependent clinical outcomes of cardiovascular disease, cardiac protection by estrogen, cardiac health during menopause, cardiac rehabilitation programs, fitness and exercise, cardio-oncology, shift work and the CVD risk, and pregnancy related CVD.
    Type of Medium: Online Resource
    Pages: VII, 446 p. 56 illus., 38 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031399282
    Series Statement: Advances in Biochemistry in Health and Disease, 26
    DDC: 573.1
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biology Technique. ; Gynecology . ; Physiology. ; Medicine Research. ; Biology Research. ; Reproductive health. ; Biological Techniques. ; Gynecology. ; Physiology. ; Biomedical Research. ; Reproductive Medicine.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Baboon model -- Chapter 3. Mechanisms of endometriosis-associated subfertility and novel therapeutic approaches discovered using a rat model -- Chapter 4. Animal models for pain or inflammation in endometriosis -- Chapter 5 Environmental endocrine disruptors and risk of endometriosis in mouse models.-Chapter 6. Deciphering the role of miRNAs in endometriosis pathophysiology using experimental endometriosis mouse models -- Chapter 7.Summation and future needs. .
    Abstract: This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis. Covering models ranging from rodents to baboons, it explores novel mechanisms involved in the pathophysiology of endometriosis. Topics range from the role of miRNAs and environmental endocrine disrupters to pain and endometriosis-associated subfertility. Estimated to affect up to 10% of women, endometriosis is a widespread and in some cases debilitating disease. While studies on the pathophysiology of the disease and the development of treatments for endometriosis-associated subfertility are called for, acquiring appropriate tissues from women with and without endometriosis in combination with physiologically relevant in vitro and in vivo laboratory models is an essential aspect. However, control subjects with similar ages, living environments and medical histories, besides endometriosis, are hard to find and attaining suitable human reproductive tissues is linked to an ongoing ethical discussion, especially when studying embryos. Laboratory models like rodent and monkey models are therefore needed to fill the research gap and support hypothesis-driven, randomized, controlled experimental design studies. In this book we highlight the latest developments and findings in endometriosis research using animal models. The book was written for scientists, physicians and medical students working in the field of reproductive science, and for women with endometriosis.
    Type of Medium: Online Resource
    Pages: VII, 111 p. 12 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030518561
    Series Statement: Advances in Anatomy, Embryology and Cell Biology, 232
    DDC: 570.28
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cardiovascular system. ; Physiology. ; Biophysics. ; Cell interaction. ; Medicine Research. ; Biology Research. ; Regenerative medicine. ; Cardiovascular Physiology. ; Mechanobiological Cell Signaling. ; Biomedical Research. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Foreword -- Cardiac mechanoperception and mechanotransduction - Mechanisms of stretch sensing in cardiomyocytes and implications for cardiomyopathy -- Mechanotransduction in heart development -- Mechanobiology of cardiac growth in health and disease -- The role of mechanosensitive signaling cascades in repair and fibrotic remodeling of the infarcted heart -- Mechanobiology of cardiac fibroblasts in cardiac remodelling -- Mechanobiology of cardiac remodelling in cardiomyopathy -- Biophysical Stretch Induced Differentiation and Maturation of Induced Pluripotent Stem Cell-derived Cardiomyocytes -- Mechanical Considerations of Myocardial Tissue and Cardiac Regeneration -- Mechanobiology of Exercise-Induced Cardiac Remodeling in Health and Disease -- Cardiac microvascular endothelial cells and pressure overload-induced cardiac fibrosis -- Cellular and Subcellular Mechanisms of Ventricular Mechano-Arrhythmogenesis -- Computational biomechanics of ventricular dyssynchrony and resynchronization therapy -- Therapeutic innovations for heart failure.
    Abstract: This book presents the latest findings in the field of cardiac mechanobiology in health and disease. Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells. This volume of the series Cardiac and Vascular Biology complements the volume Vascular Mechanobiology in Physiology and Disease (volume 8) published in this series. The book is aimed at clinicians as well as researchers in cardiovascular biology, bioengineering and biophysics, and also represents an educational resource for young researchers and students in these fields.
    Type of Medium: Online Resource
    Pages: VIII, 353 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031239656
    Series Statement: Cardiac and Vascular Biology, 9
    DDC: 573.1
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biology Technique. ; Animal welfare Moral and ethical aspects. ; Medicine Research. ; Biology Research. ; Experimental Organisms. ; Animal Ethics. ; Biomedical Research.
    Description / Table of Contents: Introduction -- Critique -- The Ideal Study -- What Can Go Wrong? -- Does It Really Go Wrong? -- The Consequences -- Construction -- Summary and Conclusions.
    Abstract: This book examines animal research conducted with the goal of medical translation to humans. It is written by Dr. Bradley Weiner, a surgeon who is active at a high level clinically and in biomedical research. After documenting that the vast majority of biomedical animal research fails to result in benefits to humans via translation, the book examines the sources of such failure; including the failure to justify the use of animals, the failure to properly apply scientific methods, the failure to perform the research properly in the lab, the failure to consider the possibility of translation a priori, and systematic sources of failure built into the biomedical research enterprise. The book then explores options to improve the situation, for the benefit of both the animals and humans.
    Type of Medium: Online Resource
    Pages: XIII, 62 p. 2 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031246777
    DDC: 570.28
    Language: English
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cardiovascular system. ; Physiology. ; Cardiology. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Cardiovascular Physiology. ; Cardiology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research.
    Description / Table of Contents: Section I: Normal Cardiomyocyte and its Growth -- 1. Structure and Function of Cardiomyocyte -- 2. Development of Cardiomyocyte -- 3. Cell Cycle Regulation in Cardiomyocytes -- 4. Cardiac Fibroblast and Cardiomyocyte Growth -- 5. Role of Endocardium and Epicardium in Generation of Cardiomyocytes -- Cardiomyocytes in the Mammalian Adult Heart -- 7. Energy Metabolism in Cardiomyocytes -- Section II: Cardiomyocyte Responses 8. Response of Cardiomyocytes to Mechanical Stress -- Cardiomyocyte Responses to Hormones 10. Sequelae of Genetic Defects in Cardiomyocytes -- 11. Response and Effects of Cardiomyocyte Progenitors in the Infarcted Heart -- Section III: Cardiomyocyte Aging and Death -- 12. Cardiomyocyte Senescence -- 13. Mechanisms of Cardiomyocyte Death -- 14. Cardiomyocyte Response to Ischemic Injury -- 15. Cardiomyocytes in Heart Failure -- Section IV: Cardiomyocyte Regeneration -- 16. Endogenous Mechanisms for Cardiomyocyte Regeneration -- 17. Mechanisms to Induce Cardiomyocyte Proliferation -- 18. Cell Sources of Cardiomyocytes for Heart Repair -- 19. Reprograming Fibroblasts for Cardiomyocytes and Progenitors -- Section V: Translational Aspects of Cardiomyocyte Biology -- 20. Clinical Translation of Discoveries in Cardiomyocyte Biology.
    Abstract: This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon. .
    Type of Medium: Online Resource
    Pages: XXVII, 345 p. 44 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030855369
    DDC: 573.1
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biology Technique. ; Medicine Research. ; Biology Research. ; Surgery. ; Experimental Organisms. ; Biomedical Research. ; Biological Techniques. ; Surgery.
    Description / Table of Contents: Chapter 1 -- The Basics -- Chapter 2. Collecting Specimen and Harvesting Tissues -- Chapter 3. Drugs Administration -- Chapter 4. Surgical Principles -- Chapter 5. Vascular Surgery. .
    Abstract: This book fills the current void of academic writings on laboratory mouse operation, giving research scientists, graduate students, and laboratory technicians an authoritative textbook and definitive laboratory companion. It covers mouse anatomy, the handling of the mouse, anesthesia, drug administration, specimen collection, organ harvesting and daily laboratory skills as well as advanced micro-surgery techniques. Its detailed description of mouse anatomy corrects many inaccuracies and misconceptions in the literature. It provides a wealth of basic laboratory skills and numerous advanced surgical techniques. The step-by-step explanations, with extensive photographic images and videos, improve the current understanding and practice of laboratory mouse operations. This book lays the foundation of laboratory mouse operations by offering a clear understanding of the basic principles, updated anatomic studies, and providing invaluable practical tools. It serves a wide audience, including laboratory animal scientists, pharmaceutical science researchers, graduate students in these fields, micro surgeons, veterinarians, and laboratory technicians. .
    Type of Medium: Online Resource
    Pages: XVII, 1070 p. 3067 illus., 3039 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783030745011
    DDC: 570.28
    Language: English
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