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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Surfaces (Physics). ; System theory. ; Zoology. ; Botany. ; Biology Technique. ; Computational and Systems Biology. ; Surface and Interface and Thin Film. ; Complex Systems. ; Zoology. ; Plant Science. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Various methods of pattern formation -- Chapter 3. Clusterization of biological structures with high aspect ratio -- Chapter 4. Contact between biological attachment devices and rough -- Chapter 5. Anisotropic friction in biological systems -- Chapter 6. Mechanical interlocking of biological fasteners -- Chapter 7. Biomechanics at the microscale -- Chapter 8. Nanoscale pattern formation in biological surfaces -- Chapter 9. Ecology and evolution.
    Abstract: Basic laws of nature are rather simple, but observed biological structures and their dynamic behaviors are unbelievably complicated. This book is devoted to a study of this “strange” relationship by applying mathematical modeling to various structures and phenomena in biology, such as surface patterns, bioadhesion, locomotion, predator-prey behavior, seed dispersal, etc. and revealing a kind of self-organization in these phenomena. In spite of diversity of biological systems considered, two main questions are (1) what does self-organization in biology mean mathematically and (2) how one can apply this knowledge to generate new knowledge about behavior of particular biological system? We believe that this kind of “biomimetics” in computer will lead to better understanding of biological phenomena and possibly towards development of technical implications based on our modeling.
    Type of Medium: Online Resource
    Pages: XVIII, 317 p. 151 illus., 69 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030415280
    Series Statement: Biologically-Inspired Systems, 16
    DDC: 570.285
    Language: English
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  • 2
    Keywords: Paleoecology. ; Paleontology . ; Bioinformatics. ; Archaeology. ; Earth sciences. ; Paleoecology. ; Paleontology. ; Computational and Systems Biology. ; Archaeology. ; Earth Sciences.
    Description / Table of Contents: Chapter 1-Introduction -- Chapter 2-Historical perspective -- Chapter 3-Geology and stratigraphy -- Chapter 4-Indian late cretaceous dinosaur nesting sites -- Chapter 5-Discussion. Chapter -- 6-Summary and conclusions.
    Abstract: This book documents analyses of the Late Cretaceous dinosaur nesting sites of the Lameta Formation at Jabalpur, Districts Dhar and Jhabua, Madhya Pradesh; Districts Kheda and Panchmahal (Gujarat); and the Pisdura, Dongargaon and Pavna sectors in the Chandrapur Districts of Maharashtra, which are exposed in India along an east-west and central axis. In this work, special emphasis has been given to the dinosaur nesting sites of the east-central Narbada River region, including its regional geology. The work was undertaken to provide detailed information concerning dinosaur eggs, eggshell fragments, nests and clutches found in the Lameta Formation of peninsular India. Prior to the present work there had been no detailed review of systematic work on the taxonomy, and of micro- and ultrastructural studies of dinosaur eggs and eggshells from the Lameta Formation. The study documents the field and laboratory investigations that facilitated the reconstruction of the morphotaxonomy, models for the burial pattern of eggs and eggshells, taphonomic implications,and the palaeoenvironmental context and palaeoecological conditions during the Late Cretaceous at the time of the extrusion of the Deccan traps, which may have been partly responsible for the extinction of the dinosaurs. The need to follow a parataxonomic classification for Indian dinosaur eggs and eggshell types is very apparent, and this book addresses this aspect in some detail. The emphasis on the application of parataxonomic schemes is based on the description of new oospecies and their comparison with previously known forms. The present work has led to the recovery of numerous nests, many collapsed eggs and hundreds of dinosaur eggshell fragments from the localities situated near the east, west and central Narbada River regions. It will be of interest to academics and professional palaeontologists, and all students of dinosaurs.
    Type of Medium: Online Resource
    Pages: XX, 280 p. 92 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030564544
    Series Statement: Topics in Geobiology ; 51
    DDC: 560.45
    Language: English
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  • 3
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biomaterials. ; Nucleic acids. ; Bioinformatics. ; Biology Technique. ; Nucleic Acid. ; Computational and Systems Biology. ; Biological Techniques.
    Description / Table of Contents: Chapter 1. Strategies in Life sciences -- Chapter 2. Management and Manufacturing process of biologics -- Chapter 3. Downstream processes -- Chapter 4. Bioprinting -- Chapter 5. Biopharmaceuticals: New Frontier.
    Abstract: Tailoring of biomolecules using protein engineering technology, and host cells culture techniques are among the most sophisticated and elegant achievements of modern applied life sciences in which the basic fundamentals biotechnology are applicable for the development and manufacturing of biologics and other related bio-molecules for a hurdle free life with good health. A majority of biologics derived from genetically modified host cells in the current market are bio-formulation such as antibodies, nucleic acid products and vaccines. Such bio-formulations are developed mainly in two steps i.e. upstream process and downstream process. The first volume of this series begins with the latest information on how the classical stepwise host cells culture (mammals, animals, plants, and bacteria) methodology has been changed to fully continuous or partially continuous host cells culture process in order to economise the biopharmaceutical products manufacturing process. In addition this volume narrates a brief history on conceptual development of new thoughts in designing biotechnology industries for commercial production of variety of therapeutic proteins with structural modification on the basis of clinical requirements. The readers will feel exited by going through the latest discovery and development in applied life sciences for designing innovative biomolecules for health care with utmost safe. The most interesting part of this volume is newly developed concept on bioprinting. It explains how to design and fabricate animate objects by fusing or depositing material of interest in the form of powders, solid dusts, metal, liquid or even living cells or tissues by layers to produce 3D objectives. The first volume ends with the latest information on the current trend in biologics market, market dynamic, drives, and opportunities with challenges.
    Type of Medium: Online Resource
    Pages: XV, 189 p. 84 illus., 56 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811575907
    Series Statement: New Paradigms of Living Systems, 1
    DDC: 620.19
    Language: English
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  • 4
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Bioinformatics. ; Immunology. ; Cancer Biology. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: 1. Introduction: Introduction of lipids, lipid metabolism and tumor immunity -- 2. ipid metabolism and lipidomics -- 3. Applications of lipidomics in tumour immunity.-4. Overview: Lipid metabolism in tumour microenvironment -- 5. Lipid metabolism in cancer cells -- 6. Lipid metabolism in tumour-associated NK -- 7. Lipid metabolism in tumour-associated macrophages -- 8. Lipid metabolism in tumour-associated MDSCs -- 9. Lipid metabolism in tumour-associated fibroblasts -- 10. Lipid metabolism in tumour-associated B cells -- 11. Lipid metabolism in tumour-infiltrating T cells -- 12. Lipid metabolism and angiogenesis -- 13. Lipid metabolism and tumor antigen-presenting -- 14. Lipid metabolism and immune checkpoints.
    Abstract: This book focuses on lipid metabolism in tumor immunity, covering the application of lipidomics in tumor immunity and all aspects of lipid metabolism in tumor microenvironment. During the progression of tumors, tumor cells and immune cells interact in a dynamic microenvironment. Targeting the immune system has a high potential for treating cancer. However, due to the high heterogeneity of the tumor microenvironment, only a small percentage of patients experience such clinical benefits of tumor immunotherapy. Therefore, understanding the tumor microenvironment is crucial for tumor immunity. Recently, lipid metabolism is an emerging research direction and contributes to cell survival and biofunctions in tumor microenvironment, which is of great interest and significance to be elucidated. This book provides the doctors, researchers, and scientists with a cutting-edge overview of the lipid metabolism and its role in tumor immunity. It also yields benefits for pharmaceutical companies regarding drug discovery. .
    Type of Medium: Online Resource
    Pages: XI, 211 p. 24 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813367852
    Series Statement: Advances in Experimental Medicine and Biology, 1316
    DDC: 571.978
    Language: English
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  • 5
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Human physiology. ; Radiology. ; Diseases. ; Bioinformatics. ; Immunology. ; Human Physiology. ; Radiology. ; Diseases. ; Computational and Systems Biology. ; Immunology.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. The Economics of Obesity-A Public Policy Perspective -- Chapter 3. Obesity and skin problems -- Chapter 4. Obesity and endometriosis -- Chapter 5. Hypogonadism -- Chapter 6. Effect of obesity in cardiovascular system -- Chapter 7. Impact of obesity on vaccination -- Chapter 8. Obesity-linked diseases (Comorbidities) -- Chapter 9. Imaging as a tool for measuring body fat -- Chapter 10. Extrapolation from clinical trial to practice: current pharmacotherapy on obesity -- Chapter 11. Nanotechnology in the context of obesity -- Chapter 12. Computational approach in drug development for obesity.
    Abstract: This book summarizes the effects of obesity on health and its correlation with a wide range of debilitating and life-threatening conditions in humans. It discusses the possible pathological mechanisms that are involved in the development of obesity and highlights obesity-associated molecular mechanisms that contribute to reproductive dysfunctions in men and women. The book provides mechanistic insights on the role of obesity in cardiovascular and respiratory disorders, and examines the role of the complementary molecular mechanism of the gut microbiota in the development of obesity. It also reviews the interaction between the metabolic system and immune cells in the pathogenesis of obesity-associated diseases. Lastly, it assesses the latest advances in nanomedicine as an emerging strategy for the treatment of obesity.
    Type of Medium: Online Resource
    Pages: XVI, 181 p. 13 illus., 6 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813364080
    DDC: 612
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Post-translational modification. ; Bioinformatics. ; Molecular biology. ; Nervous system Diseases. ; Post-translational Modifications. ; Computational and Systems Biology. ; Molecular Biology. ; Neurological Disorders.
    Description / Table of Contents: Protein extraction and sample preparation methods for shotgun proteomics with central nervous system cells and brain tissue -- Phosphopeptide enrichment techniques: a pivotal step for phosphoproteomic studies -- Post-Translational Modifications during Brain Development -- Aberrant protein glycosylation in brain cancers, with emphasis on glioblastoma -- Post-Translational Modification in Muscular Dystrophies -- Post-translational Modifications in Parkinson’s Disease -- Histone Modifications in Neurological Disorders -- Mitochondrial dysregulation and the influence in neurodegenerative diseases -- PTMs: A missing piece for schizophrenia studies -- Post-Translational Modifications in Brain Diseases: A Future for Biomarkers -- Index.
    Abstract: This new volume, a part of the Proteomics, Metabolomics, Interactomics and Systems Biology series, will explain how proteomic studies of post-translational modifications (PTMs) can be applied to neurodegenerative diseases and relevant studies. The goal of the book is to increase awareness among researchers about how PTMs may be helpful in understanding mechanisms in various neurodegenerative diseases through proteomic studies. This book will serve as a tool for those who want to begin work in the proteomics field and explore how to implement PTMs studies into their work. Chapter authors will describe different PTMs enrichment methods developed by experts in the field so that researchers may learn to apply these methods and techniques to new studies. Divided into three sections, chapters will cover sample preparation, data quality, enrichment techniques, guidelines on how to analyze PTMs, and explain the role of PTMs and different brain diseases. Among those topics includes will be brain cancer, SLA disease, Parkinsons disease, muscular dystrophies, and schizophrenia. This volume will be useful for researchers and students studying brain and neurodegenerative diseases who are interested in delving into work with proteomic studies and PTMs. .
    Type of Medium: Online Resource
    Pages: VIII, 146 p. 13 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031054600
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1382
    DDC: 572.645
    Language: English
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  • 7
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Food science. ; Nutrition   . ; Bioinformatics. ; Biotechnology. ; Food Science. ; Nutrition. ; Computational and Systems Biology. ; Biotechnology.
    Description / Table of Contents: Soybean (Glycine max) -- Rapeseed/Canola (Brassica napus) -- Cottonseed (Gossypium hirsutum),- Ground nut (Arachis hypogaea) -- Sunflower (Helianthus annuus) seed -- Palm /Palm kernel (Elaeis guineensis) -- Coconut (Cocos nucifera),- Mustard (Brassica nigra) seed,- Olive (Olea europaea),- Flaxseed (Linum usitatissimum), - Chia seed (Salvia hispanica),- Sesame (Sesamum indicum) seed -- Nigella (Nigella sativa) seed,- Borage (Borago officinalis) seed,- Hempseed (Cannabis sativa),- Rice (Oryza sativa) bran,- Safflower (Carthamus tinctorius) -- Camelina (Camelina sativa) seed,- Pumpkin (Cucurbita pepo) seed,- Cumin (Cuminum cyminum) seed.
    Abstract: Oilseeds offer a plethora of opportunities for the food and feed industry, thanks to their high oil and protein content . Their phytonutrients and functional components have attracted the interest of researchers, leading to the development of functional foods. This book gathers the latest scientific information on the nutrients, phytonutrients and health benefits as well as the adverse effects of consuming various conventional and non-conventional oilseeds. In addition, each chapter includes a section comprehensively explaining the use of oilseeds in functional bakery, dairy, and other food products. Given its scope, the book is a valuable resource for students, researchers, nutritionists, food scientists and technologists, and for anyone involved in product development based on oilseed and its components.
    Type of Medium: Online Resource
    Pages: IX, 517 p. 42 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811541940
    DDC: 641.3
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Bioinformatics. ; Imaging systems in biology. ; Cell Biology. ; Computational and Systems Biology. ; Biological Imaging.
    Description / Table of Contents: Introduction -- Batch Processing Methods in ImageJ -- Python: Data Handling, Analysis and Plotting -- Building a Bioimage Analysis Workflow Using Deep Learning -- GPU-Accelerating ImageJ Macro Image Processing Workflows Using CLIJ -- How to Do the Deconstruction of Bioimage Analysis Workflows: A Case Study with SurfCut -- i.2.i. with the (Fruit) Fly: Quantifying Position Effect Variegation in Drosophila Melanogaster -- A MATLAB Pipeline for Spatiotemporal Quantification of Monolayer Cell Migration.
    Abstract: This open access textbook aims at providing detailed explanations on how to design and construct image analysis workflows to successfully conduct bioimage analysis. Addressing the main challenges in image data analysis, where acquisition by powerful imaging devices results in very large amounts of collected image data, the book discusses techniques relying on batch and GPU programming, as well as on powerful deep learning-based algorithms. In addition, downstream data processing techniques are introduced, such as Python libraries for data organization, plotting, and visualizations. Finally, by studying the way individual unique ideas are implemented in the workflows, readers are carefully guided through how the parameters driving biological systems are revealed by analyzing image data. These studies include segmentation of plant tissue epidermis, analysis of the spatial pattern of the eye development in fruit flies, and the analysis of collective cell migration dynamics. The presented content extends the Bioimage Data Analysis Workflows textbook (Miura, Sladoje, 2020), published in this same series, with new contributions and advanced material, while preserving the well-appreciated pedagogical approach adopted and promoted during the training schools for bioimage analysis organized within NEUBIAS – the Network of European Bioimage Analysts. This textbook is intended for advanced students in various fields of the life sciences and biomedicine, as well as staff scientists and faculty members who conduct regular quantitative analyses of microscopy images.
    Type of Medium: Online Resource
    Pages: X, 212 p. 265 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030763947
    Series Statement: Learning Materials in Biosciences,
    DDC: 571.6
    Language: English
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  • 9
    Keywords: Phylogeny. ; Biology Technique. ; Gene expression. ; Bioinformatics. ; Phylogenetics. ; Gene Expression Analysis. ; Bioinformatics.
    Description / Table of Contents: Introduction to phylogenetic trees -- A divergence time story: the rise and fall of the molecular clock -- Estimating phylogenetic trees -- Estimating divergence times -- Estimating common ancestors -- Testing theories of molecular evolution -- Recommendations for further reading -- Appendix A: Intermittent point processes -- Appendix B: Poisson processes with Lévy-stable substitution rates.
    Abstract: This book serves as a brief introduction to phylogenetic trees and molecular evolution for biologists and biology students. It does so by presenting the main concepts in a variety of ways: first visually, then in a history, next in a dice game, and finally in simple equations. The content is primarily designed to introduce upper-level undergraduate and graduate students of biology to phylogenetic tree reconstruction and the underlying models of molecular evolution. A unique feature also of interest to experienced researchers is the emphasis on simple ways to quantify the uncertainty in the results more fully than is possible with standard methods.
    Type of Medium: Online Resource
    Pages: XIII, 106 p. 21 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031119583
    Series Statement: SpringerBriefs in Systems Biology,
    DDC: 576.88
    Language: English
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  • 10
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Cancer. ; Diseases. ; Immunology. ; Bioinformatics. ; Cancer Biology. ; Diseases. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Obesity induced chronic low-level inflammation and cancers -- Chapter 2. Adipose tissue produced estrogen as risk factor for cancers -- Chapter 3. Insulin and Insulin-like growth factor-1 associated cancers.-Chapter 4. Adipokines play important role in cell proliferation and antiproliferation -- Chapter 5. mTOR and AMP-activated protein kinase in obesity and cancer -- Chapter 6. Immune response and oxidative stress in obesity induced cancer -- Chapter 7. Role of gene polymorphism in obesity and cancer -- Chapter 8. Therapeutic role of green tea in obesity and cancer -- Chapter 9. Effect of dietary phytochemicals in obesity and cancer -- Chapter 10. Resveratrol as anti-obesity and anticancer agent -- Chapter 11. EGCG as anti-obesity and anticancer agent -- Chapter 12. miRNAs as therapeutic target in obesity and cancer -- Chapter 13. In silico updates on lead identification for obesity and cancer -- Chapter 14. In vivo models for obesity and obesity related carcinogenesis -- Chapter 15. Estrogen signaling based current and potential therapies against obesity and related diseases -- Chapter 16. Autophagy at the crossroad of obesity mediated cancer progression.
    Abstract: This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry. .
    Type of Medium: Online Resource
    Pages: IX, 361 p. 38 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618468
    DDC: 571.978
    Language: English
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  • 11
    Keywords: Bioinformatics. ; Biology Technique. ; Life sciences. ; Bioinformatics. ; Computational and Systems Biology. ; Biological Techniques. ; Life Sciences.
    Description / Table of Contents: Chapter 1. Prelusion Significance of Livestock -- Chapter 2. Mass Balance concept in Livestock Farming -- Chapter 3. Goat and Sheep Farming -- Chapter 4. Cattle and Buffaloes Farming -- Chapter 5. Factors Influencing Livestock Way of Life -- Chapter 6. Sustainable Livestock Farming -- Chapter 7. Conceptual Development of Livestock Supply Chain Management.
    Abstract: Basic principles of applied life sciences such as recombinant DNA technology is used in most life sciences industries marketing bio-formulations for designing more effective protein-based drugs, such as erythropoietin and fast-acting insulin etc. In recent times genetically engineered host cells from mammal, animal and plants are also being used in life sciences industries to manufacture biologics. This book discusses the most basic as well advanced issues on biological products for successfully managing a life sciences industry. It elucidates the life cycle of biological molecules, right from the conceptual development of different types of biopolymers, and their subsequent transfer from the conical flasks in laboratory to life sciences industries for large scale production and marketing. It focuses on sustainable longevity in the life cycle of commercial biopolymers. Cumulative facts and figures in this volume would immensely help in inspiring life sciences industry promoters to monitor value chain transfer process of biologics for better profitability. Additionally, it would serve as a perusal document for the students and researchers interested in entrepreneurial ventures or having their own start-up projects for the commercialization of biologics. .
    Type of Medium: Online Resource
    Pages: XVI, 207 p. 101 illus., 63 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811620515
    Series Statement: New Paradigms of Living Systems, 2
    DDC: 570.285
    Language: English
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  • 12
    Keywords: Zoology. ; Environment. ; Bioinformatics. ; Ecology . ; Biodiversity. ; Physical geography. ; Zoology. ; Environmental Sciences. ; Computational and Systems Biology. ; Ecology. ; Biodiversity. ; Earth System Sciences.
    Description / Table of Contents: Introduction -- Historical review of research on Arctic and Subarctic Aleocharinae -- Material and methods -- Impact of climate change on northern fauna and flora -- Aleocharinae as indicators of change -- Faunal analysis and discussion -- Key to tribes occurring in Arctic and Subarctic zones -- Tribe Gymnusini Heer, 1839 -- Tribe Aleocharini Fleming, 1821 -- Tribe Oxypodini C.G. Thomson, 1859 -- Tribe Tachyusini C.G. Thomson, 1859 -- Tribe Hypocyphtini Laporte, 1835 -- Tribe Myllaenini Ganglbauer, 1895 -- Tribe Liparocephalini Fenyes, 1918 -- Tribe Homalotini Heer, 1839 -- Tribe Placusini Mulsant and Rey, 1871 -- Tribe Athetini Casey, 1910 -- Tribe Falagriini Mulsant and Rey, 1873.
    Abstract: Arctic and Subarctic North America is particularly affected by climate change, where average temperatures are rising three times faster than the global average. Documenting the changing climate/environment of the north requires a structured knowledge of indicator taxa that reflect the effects of climate changes. Aleocharine beetles are a dominant group of forest insects, which are being used in many projects as indicators of environmental change. Many species are forest specialists restricted to certain microhabitats, some are generalists and others are open habitat specialists. They represent many ecological niches and, as such, are good indicators for many other species as well. The majority of Canadian aleocharine beetle species (about 600 spp.) has been studied and published by Jan Klimaszewski et al. (2018, 2020), mainly from southern, central, and western Canada, while the northern taxa remain poorly known and documented. The aim of the present book is to summarize the knowledge on this insect group in the Arctic and Subarctic North America and to provide a diagnostic and ecological tool for scientists studying and monitoring insects in northern Canada and Alaska. The book includes a review of the literature, information on 238 species and their habitats, taxonomic review, images, and identification tools.
    Type of Medium: Online Resource
    Pages: XIV, 712 p. 315 illus., 307 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030681913
    DDC: 590
    Language: English
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  • 13
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Biomedical engineering. ; Radiology. ; Bioinformatics. ; Biotechnology. ; Biomedical Engineering and Bioengineering. ; Radiology. ; Computational and Systems Biology.
    Description / Table of Contents: Deep Learning in Medical Image Analysis -- Medical Image Synthesis via Deep Learning -- Deep Learning for Pulmonary Image Analysis: Classification, Detection, and Segmentation -- Deep Learning Computer Aided Diagnosis for Breast Lesion in Digital Mammogram -- Decision support system for lung cancer using PET/CT and microscopic images -- Lesion Image Synthesis using DCGANs for Metastatic Liver Cancer Detection -- Retinopathy analysis based on deep convolution neural network -- Diagnosis of Glaucoma on retinal fundus images using deep learning: detection of nerve fiber layer defect and optic disc analysis -- Automatic segmentation of multiple organs on 3D CT images by using deep learning approaches -- Techniques and Applications in Skin OCT Analysis -- Deep Learning Technique for Musculoskeletal Analysis -- Index.
    Abstract: This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.
    Type of Medium: Online Resource
    Pages: VIII, 181 p. 131 illus., 114 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030331283
    Series Statement: Advances in Experimental Medicine and Biology, 1213
    DDC: 660.6
    Language: English
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  • 14
    Keywords: Food science. ; Business Data processing. ; Bioinformatics. ; Food Engineering. ; Business Informatics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1 - Poultry and Egg Production: An Overview -- Chapter 2 - Egg formation and Embryonic Development: An Overview -- Chapter 3 - Chemometric for Spectroscopy-Based Poultry and Egg Research -- Part-I: Table Eggs -- Chapter 4 - Non-destructive Quality Assessment of Table Eggs for Online Sorting -- Part-II: Hatching Eggs -- Chapter 5 - Grading of Hatching Eggs -- Chapter 6 - Non-destructive Technologies for Embryo Gender Prediction -- Chapter 7 - Hatch Window Monitoring, Control and Management -- Chapter 8 -: Chick Embryo Grading: A Future Tool for Precision Poultry Production -- Chapter 9 - A Vision for Smart Poultry Production to Achieve Multiple SDGs.
    Abstract: This book discusses table and hatching eggs, quality-based grading of eggs, pre-incubation, incubation, hatching and post-hatch monitoring period, and how the next-generation management of these process can be enriched by informatics through non-destructive technologies, signal processing, machine learning, AI, IoT applications, etc. This book will be a beneficial resource for egg and poultry science researchers, avian biologists and ecologists, developmental biologists, agricultural engineers, advanced graduate and postgraduate students, and poultry production industry stakeholders.
    Type of Medium: Online Resource
    Pages: XIV, 156 p. 76 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811925566
    DDC: 664
    Language: English
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  • 15
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: S-MEDUTA: Combining Balanced Scorecard with simulation and MCDA techniques for the evaluation of the strategic performance of an Emergency Department -- An Architecture For Cooperative Mobile Health Applications -- An Educational Scenario for the Learning of the Conic Section: Studying the Ellipse with the Use of Digital Tools and Elements of Differentiated Instruction and Cognitive Neurosciences 45 -- Antibody clustering using a machine learning pipeline that fuses genetic, structural and physicochemical properties -- Neuroeducation and computer programming. A review -- Towards Analyzing Next Generation Sequencing Algorithms -- WOL Ecosystem: Secure remote power-state control of computer(s) over the internet for telemedicine purposes and dementia patients -- Epidemics Fuzzy Decision-Making Applications and Fuzzy Genetic Algorithms Efficiency Enhancement -- Multivariate data analysis and machine learning for prediction of MCI-to-AD conversion -- A Deep Learning Approach for Human Action Recognition using Skeletal Information -- Artificial Neural Networks in Computer Aided Drug Design. An overview of recent advances -- Computation of dolphins’ sound aspl while foraging -- Novel cost function definition for minimum-cost Tractography in MR Diffusion Tensor Imaging -- Platform for managing medical data by using a passive electronic device -- Evaluation of a computerized cognitive screening tool (ADPS, Altoida) in a sample of community-dwelling older adults -- Interconnections and Modeling Schemes of Kinesia Paradoxa -- Knowledge Discovery on IoT-enabled mHealth Applications -- Computational approaches applied in the field of neuroscience -- Drugena: A fully automated immunoinformatics platform for the design of antibody drug conjugates against neurodegenerative diseases -- Brain-Computer Interface Design and Neurofeedback Training in the case of ADHD Rehabilitation -- Particular biomolecular processes as computing paradigms -- Decision trees and applications -- Utilization of new technologies in the production of pharmaceutical olive oil -- A survey of evolutionary games in biology -- DTCo: An ensemble SSL algorithm for X-rays classification -- Cognitive Enhancement and Brain-Computer Interfaces. Potential Boundaries and Risks -- Informatics and cognitive assessment: a RUDAS scale paradigm -- Effective stochastic algorithm in disease prediction -- A Systems Biology Approach for the Identification of Active Molecular Pathways during the Progression of Alzheimer’s Disease -- A brief survey of the Prisoners' Dilemma game and its potential use in biology -- Validation of modeling and simulation methods in computational biology -- An improved self-labeled algorithm for cancer prediction -- eHealth application for e-bloodanalysis, e-diagnosis and digital diet guidance -- Modeling the critical activation of chaperone machinery in protein folding -- ANTISOMA: A computational pipeline for the reduction of the aggregation propensity of monoclonal antibodies -- A microscale mathematical blood flow model for understanding cardiovascular diseases -- Blockchain For Mobile Health Applications Acceleration With GPU Computing -- Finite Size Effects in Networks of Coupled Neurons -- Detecting common pathways and key molecules of Neurodegenerative Diseases from the topology of molecular networks -- Robotic Systems involved in the diagnosis of Neurodegenerative diseases -- Undergraduate Students’ Brain Activity in Visual and Textual Programming -- Fuzzy logic Systems and Medical Applications -- Apache Spark Implementations for String Patterns in DNA Sequences -- Big Data Analysis and Genetic Liability to Neuropsychiatric Disease -- Mathematical models and computer simulation of chemical carninogenesis process and its inhibition by antocarcinogenic substances -- Transitioning knowledge levels through problem-solving methods -- Cellular phone user’s age or the duration of calls moderate autonomic nervous system? A meta-analysis -- Logical Analysis and Validation of Publications in Bioinformatics.
    Abstract: The 3rd World Congress on Genetics, Geriatrics, and Neurodegenerative Disease Research (GeNeDis 2018), focuses on recent advances in genetics, geriatrics, and neurodegeneration, ranging from basic science to clinical and pharmaceutical developments. It also provides an international forum for the latest scientific discoveries, medical practices, and care initiatives. Advanced information technologies are discussed, including the basic research, implementation of medico-social policies, and the European and global issues in the funding of long-term care for elderly people. .
    Type of Medium: Online Resource
    Pages: XIII, 508 p. 129 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030326227
    Series Statement: Advances in Experimental Medicine and Biology, 1194
    DDC: 616.042
    Language: English
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  • 16
    Keywords: Medicine Research. ; Biology Research. ; Bioinformatics. ; Cancer. ; Biomedical Research. ; Bioinformatics. ; Cancer Biology.
    Description / Table of Contents: Values of single-cell sequencing and methylation in molecular diagnosis and therapy -- Single-cell sequencing in human diseases -- Single-cell sequencing of T cell receptors: A perspective on the technological development and translational application -- DNA Methylation in pulmonary fibrosis -- Molecular regulation and clinical significance of caveolin-1 methylation in chronic lung diseases -- Research advances on DNA methylation in idiopathic pulmonary fibrosis -- DNA Methylation in Chronic Obstructive Pulmonary Disease -- Single cell sequencing: a new dimension in cancer diagnosis -- The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers -- Clinical Significance of P16 Gene Methylation in Lung Cancer -- Application of single-cell RNA sequencing in pancreatic cancer and the endocrine pancreas -- Single Cell Sequencing in GU Malignancies -- PI3K Isoform-Selective Inhibitors in Cancer -- Single cell RNA sequencing in human disease: Renal, pancreatic, and viral diseases -- Single-cell sequencing in human genital infections -- PI3kinase Inhibitors in Thrombosis and Cardiovascular Disease -- Use of single-cell microfluidic technology towards therapeutic antibody discovery from single B cells.
    Abstract: With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.
    Type of Medium: Online Resource
    Pages: VIII, 247 p. 117 illus., 114 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811544941
    Series Statement: Advances in Experimental Medicine and Biology, 1255
    DDC: 610.72
    Language: English
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  • 17
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Pharmacology. ; Bioinformatics. ; Oncology. ; Medicine Philosophy. ; Pharmacology. ; Computational and Systems Biology. ; Oncology. ; Philosophy of Medicine.
    Description / Table of Contents: Chapter 1. Revisiting the concept of human disease (Mariano Bizzarri, Mirko Minini, and Noemi Monti) -- Chapter 2. Dynamical aspects of pharmacokinetic/pharmacodynamics and quantitative systems pharmacology models (Ioannis Loisios-Konstantinidis, Panteleimon D. Mavroudis, Panos Macheras) -- Chapter 3. The efficiency of multi-target drugs: a network approach (Lucas N. Alberca, Alan Talevi) -- Chapter 4. Mining Complex Biomedical Literature for Actionable Knowledge on Rare Diseases (Vinicius M. Alvesa, Stephen J. Capuzzia, Nancy Baker, Eugene N. Muratov, Alexander Trospsha, and Anthony J. Hickey) -- Chapter 5. Big Data, Personalized Medicine and Network Pharmacology: beyond the current paradigms (Alessandro Giuliani and Virginia Todde) -- Chapter 6. Epigenetic Control Using Small Molecules in Cancer (Tomohiro Kozako, Yukihiro Itoh, Shinichiro Honda, Takayoshi Suzuki) -- Chapter 7. Multiscale Modelling of Cancer: Micro-, Meso- and Macro-scales of Growth and Spread (Mark AJ Chaplain) -- Chapter 8. Precision Oncology vs Phenotypic approaches in the management of cancer: a case for the postmitotic state (Armando Aranda-Anzaldo and Myrna A.R. Dent) -- Chapter 9. Migrastatics - anti-metastatic drugs targeting cancer cell invasion (Aneta Gandalovičová , Daniel Rosel , Jan Brábek) -- Chapter 10. Critical steps in Epithelial-Mesenchymal transition as target for cancer treatment (Evgeny V. Denisov, Mohit Kumar Jolly, Vitaly P. Shubin, Alexey S. Tsukanov, Nadezhda V. Cherdyntseva) -- Chapter 11. Targeting the tumor-associated macrophages for ‘normalizing’ cancer (Julia Kzhyshkowska) -- Chapter 12. Tumor Reversion induced by embryo and oocyte extracts (Sara Proietti, Andrea Pensotti and Alessandra Cucina) -- Chapter 13. Trabectedin, a drug acting on both cancer cells and the tumor microenvironment (Paola Allavena, Manuela Liguori, Cristina Belgiovine) -- Chapter 14. Advances in Characterizing Recently-identified Molecular Actions of Melatonin: Clinical Implications (Russel J. Reiter, Ramaswamy Sharma, Sergio A. Rosales-Corral, Ana Coto-Montes, Jose Antonio Boga, Jerry Vriend) -- Chapter 15. Multitarget activities of Inositol and Inositol Hexakisphosphate (Ivana Vucenik) -- Chapter 16. Integration of Phytochemicals and Phytotherapy into Cancer Precision Medicine (Nadire Özenver and Thomas Efferth) -- Chapter 17. Synergistic Effects of Chinese Herbal Medicine and Biological Networks (Deep Jyoti Bhuyan, Saumya Perera1, Kirandeep Kaur, Muhammad A. Alsherbiny, Mitchell Low, Sai-Wang Seto, Chun-Guang Li, Xian Zhou) -- Chapter 18. Medicinal herbs: its therapeutic use in obstetrics and gynaecology (Irene Orbe, Daniel Paz, Leyre Pejenaute, Andrea Puente, Laura Diaz de Alda, Sandra Yague, Iñaki Lete) -- Chapter 19. Overcoming Antibiotic Resistance: New Perspectives (Matteo Bassetti, Elda Righi).
    Abstract: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
    Type of Medium: Online Resource
    Pages: XVI, 483 p. 49 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030328573
    Series Statement: Human Perspectives in Health Sciences and Technology, 2
    DDC: 615
    Language: English
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  • 18
    Keywords: Botanical chemistry. ; Plant physiology. ; Bioinformatics. ; Plant ecology. ; Plant genetics. ; Plant Biochemistry. ; Plant Physiology. ; Computational and Systems Biology. ; Plant Ecology. ; Plant Genetics.
    Description / Table of Contents: Chapter 1. Plant Metabolomics: Current status and prospects -- Chapter 2. Plant Metabolites: Methods for Isolation, Purification and Characterization -- Chapter 3. Molecular markers and their application in the identification of elite germplasm -- Chapter 4. Cell and protoplast culture for production of plant metabolites -- Chapter 5. Hairy Root Culture: Secondary Metabolite Production in a Biotechnological Perspective -- Chapter 6. Methods for enhanced production of metabolites under in vitro conditions -- Chapter 7. Invasive alien plants: a potential source of unique metabolites -- Chapter 8. Modified Plant Metabolites as Nutraceuticals -- Chapter 9. Ethnomedicine and role of plant metabolites -- Chapter 10. Herbal Cosmeceuticals -- Chapter 11. Plant secondary metabolites as nutraceuticals -- Chapter 12. Bioactive secondary metabolites from lichens -- Chapter 13. Algal Metabolites and Phyco-medicine -- Chapter 14. Bioactive Metabolites in Gymnosperms -- Chapter 15. Flavonoids for Therapeutic Applications -- Chapter 16. Plant-based pigments: novel extraction technologies and applications -- Chapter 17. Plant Lectins: Sugar Binding Properties and Biotechnological Applications -- Chapter 18. Plant metabolites as Immunomodulators -- Chapter 19. Polyphenols: an overview of food sources and associated bioactivities -- Chapter 20. Plant metabolites against enteropathogens -- Chapter 21. Molecular chaperones and their applications -- Chapter 22. Bioprospecting of ethno-medicinal plants for wound healing.
    Abstract: Food security and the medicinal needs of billions of people around the world are pressing global issues, and the biodiversity and sustainable utilization of plants is of great significance in this context. Further, ethnobotanical studies are vital in the discovery of new drugs from indigenous medicinal plants, and plants with industrially important metabolites need to be cultivated to meet the growing market demand. In addition, the production of plant metabolites under in vitro conditions also has tremendous possibilities. The totipotency of plant cells plays a valuable role in the sustainable utilization of plant resources through cell, tissue and organ culture. At the same time, production can be enhanced using productive cell lines, treatment with elicitors, changing nutritional parameters and metabolic engineering. This book provides state-of-the-art information on biodiversity, conservation, ethnobotany, various aspects of In vitro secondary metabolite production, bioprospecting from various plant groups and drug discovery. It also discusses methods of extracting and characterizing drug leads from plant sources.
    Type of Medium: Online Resource
    Pages: XVIII, 581 p. 115 illus., 86 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811551369
    DDC: 572.2
    Language: English
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  • 19
    Keywords: Biotechnology. ; Bioinformatics. ; Medical genetics. ; Biotechnology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Chapter 1: Global Alignment of PPI Networks -- Chapter 2: Integrated Network-Based Computational Analysis for Drug Development -- Chapter 3: Effective Random Walk Models for Comparative Network Analysis -- Chapter 4: Computational Methods for Protein-Protein Interaction Network Alignment -- Chapter 5: Network Propagation for the Analysis of Multi_Omics Data -- Chapter 6: Motifs in Biological Networks -- Chapter 7: Bio Fabric Visualization of Network Alignments -- Chapter 8: Module Identification of Biological Networks via Graph Partition -- Chapter 9: Network Module Detection to Decipher the Heterogeneity of Cancer Mutations.
    Abstract: This book reviews recent advances in the emerging field of computational network biology with special emphasis on comparative network analysis and network module detection. The chapters in this volume are contributed by leading international researchers in computational network biology and offer in-depth insight on the latest techniques in network alignment, network clustering, and network module detection. Chapters discuss the advantages of the respective techniques and present the current challenges and open problems in the field. Recent Advances in Biological Network Analysis: Comparative Network Analysis and Network Module Detection will serve as a great resource for graduate students, academics, and researchers who are currently working in areas relevant to computational network biology or wish to learn more about the field. Data scientists whose work involves the analysis of graphs, networks, and other types of data with topological structure or relations can also benefit from the book's insights. .
    Type of Medium: Online Resource
    Pages: XII, 217 p. 42 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030571733
    DDC: 660.6
    Language: English
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  • 20
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Plant anatomy. ; Plants Evolution. ; Plant ecology. ; Plant physiology. ; Plants Reproduction. ; Computational and Systems Biology. ; Plant Anatomy and Morphology. ; Plant Evolution. ; Plant Ecology. ; Plant Physiology. ; Plant Reproduction.
    Description / Table of Contents: Preface -- Acknowledgements -- Introduction: Collecting, Observing, and Describing the Natural World -- Scientific Ferment in late Eighteenth Century Edinburgh -- Scientific Exploration During Voyages of Discovery -- ... the plants of Scotland might be equally useful -- Travels in the Interior Districts of Africa -- A good practical Botanist -- So remote a country as New Holland -- The Crew labouring under the Same disorder -- Mungo Park's Last Journey -- A Tedious and Uncomfortable Passage -- Prodrommus, Florae Novae Hollndiae -- Banks's Librarian -- Taking leave of Sir Joseph Banks -- Pollen Grains of Clarkis pulchella -- Epilogue: The greatest of Banksian botanist-librarians -- Bibliography.
    Abstract: Explorer-naturalists Robert Brown and Mungo Park played a pivotal role in the development of natural history and exploration in the late eighteenth and early nineteenth centuries. This work is a fresh examination of the lives and careers of Brown and Park and their impact on natural history and exploration. Brown and Park were part of a group of intrepid naturalists who brought back some of the flora and fauna they encountered, drawings of what they observed, and most importantly, their ideas. The educated public back home was able to gain an understanding of the diversity in nature. This eventually led to the development of new ways of regarding the natural world and the eventual development of a coherent theory of organic evolution. This book considers these naturalists, Brown, Park, and their contemporaries, from the perspective of the Scottish Enlightenment. Brown’s investigations in natural history created a fertile environment for breakthroughs in taxonomy, cytology, and eventually evolution. Brown’s pioneering work in plant taxonomy allowed biologists to look at the animal and plant kingdoms differently. Park’s adventures stimulated significant discoveries in exploration. Brown and Park’s adventures formed a bridge to such journeys as Charles Darwin’s voyage on H.M.S. Beagle, which led to a revolution in biology and full explication of the theory of evolution.
    Type of Medium: Online Resource
    Pages: XIX, 217 p. 39 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030748593
    Series Statement: Memoirs of The New York Botanical Garden, 122
    DDC: 570.285
    Language: English
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  • 21
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Bioinformatics. ; Biology Technique. ; Genomics. ; Gene expression. ; Agriculture. ; Computational and Systems Biology. ; Genomic Analysis. ; Gene Expression Analysis. ; Agriculture.
    Description / Table of Contents: Chapter 1_Introduction to Bioinformatics -- Chapter 2_Statistics for bioinformatics -- Chapter 3_ Introduction of the databases of rice -- Chapter 4_Brief insight into the evolutionary history and domestication of wild rice relatives -- Chapter 5_3000 Genome project- A brief insight -- Chapter 6_ Databases and bioinformatics tools for data mining -- Chapter 7_Sequence Alignment -- Chapter 8_Gene identification and structure Annotation -- Chapter 9_Phylogenetic Analysis -- Chapter 10_RNA Structure Prediction. -Chapter 11_Structural Proteomics -- Chapter 12_Gene ontology and pathway enrichment analysis -- Chapter 13_High throughput sequencing technologies -- Chapter 14_Mapping algorithms in high-throughput sequencing -- Chapter 15_DNA–Protein Interaction Analysis (ChIP-Seq) -- Chapter 16_RNA–Protein Interaction Analysis -- Chapter 17_SNP Identification and Discovery -- Chapter 18_Microsatellite Markers from whole genome and Transcriptomic Sequences. - Chapter 19_Genome-wide association study -- Chapter 20_Expression Profiling and Discovery of microRNA -- Chapter 21_Computational approaches in identifying long non-coding RNA -- Chapter 22_circRNA in rice -- Chapter 23_ Metagenomics -- Chapter 24_RNA-Induced Gene Silencing -- Chapter 25_Single-cell RNA sequencing technologies -- Chapter 26_Recent Advancement in NGS Technologies.
    Abstract: This book provides an up-to-date review of classic and advanced bioinformatics approaches and their utility in rice research. It summarizes databases and tools for analyzing DNA, proteins and gene expression profiles, mapping genetic variations, annotation of protein and RNA molecules, phylogenetic analysis, and pathway enrichment. In addition, it presents high-throughput technologies that are widely used to provide deep insights into the genetic architecture of important traits in the rice genome. The book subsequently discusses techniques for identifying RNA-protein, DNA-protein interactions, and molecular markers, including SNP and microsatellites, in the contexts of rice breeding and genetics. Lastly, it explores various tools that are used to identify and characterize non-coding RNA in rice and their potential role in rice research.
    Type of Medium: Online Resource
    Pages: XVI, 609 p. 49 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811639937
    DDC: 570.285
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Bioinformatics. ; Genomics. ; Botany. ; Computational and Systems Biology. ; Genomics. ; Plant Science.
    Description / Table of Contents: Chapter-1 Possibility of Uncoding Structural Organization of Genome in Rice: Prospects and Approaches By 3D Genome Sequencing -- Chapter-2 Bioinformatics Approaches for High Density Linkage Mapping in Rice Research -- Chapter-3 Quantitative Trait Locus Mapping in Rice -- Chapter-4 Metabolomics in Rice Improvement -- Chapter-5 Computational Approaches Towards Decoding the Extra Chromosomal Genome of Rice -- Chapter-6 Computational Epigenetics in Rice Research -- Chapter-7 Computational Approaches Towards Understanding Stress in Rice -- Chapter-8 Identifying Complex Polyploidy Genomes Using Bioinformatics Approaches -- Chapter-9 Perspectives and Challenges of Phenotyping in Rice -- Chapter-10 The CRISPR Technology and Application in Rice -- Chapter-11 De Novo Evolution of Genes in Rice -- Chapter-12 Artificial intelligence and machine learning in rice research -- Chapter-13 Intellectual Property and Rice Research -- Chapter-14 Plant Pathogen Co-Evolution in Rice -- Chapter-15 Conservation of Rice Germplasm by Bioinformatics Strategy -- Chapter-16 Recent Advances in Multi-Omics and Breeding Approaches Towards Drought Tolerance in Crops.
    Abstract: This book summarizes the advanced computational methods for mapping high-density linkages and quantitative trait loci in the rice genome. It also discusses the tools for analyzing metabolomics, identifying complex polyploidy genomes, and decoding the extrachromosomal genome in rice. Further, the book highlights the application of CRISPR-Cas technology and methods for understanding the evolutionary development and the de novo evolution of genes in rice. Lastly, it discusses the role of artificial intelligence and machine learning in rice research and computational tools to analyze plant-pathogen co-evolution in rice crops.
    Type of Medium: Online Resource
    Pages: XV, 359 p. 21 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811639975
    DDC: 570.285
    Language: English
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  • 23
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Pharmacy. ; Bioinformatics. ; Pharmacology. ; Pharmacy. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. 'Network Target' Theory and Network Pharmacology -- Chapter 2. Application of Network Pharmacology Based on Artificial Intelligence Algorithm in Drug R & D -- Chapter 3. Commonly used Network Pharmacology Database -- Chapter 4. Commonly used Network Pharmacology Software -- Chapter 5. Network Pharmacology and TCM Modernization Case Studies -- Chapter 6. Network Pharmacology and Modern Drug R & D Cases -- Chapter 7. Drug-based Network Pharmacology Practice Process -- Chapter 8. Disease-based Network Pharmacology Practice Process -- Chapter 9. Drug-disease-based Network Pharmacology Practice Process.
    Abstract: This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
    Type of Medium: Online Resource
    Pages: XVII, 468 p. 163 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811607530
    DDC: 615
    Language: English
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  • 24
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Plant biotechnology. ; Agriculture. ; Bioinformatics. ; Botanical chemistry. ; Plant Genetics. ; Plant Biotechnology. ; Agriculture. ; Bioinformatics. ; Plant Biochemistry.
    Description / Table of Contents: Chapter 1. Sandalwood: The King of Aroma in Plant Kingdom -- Chapter 2. Historical and Cultural Importance of Sandalwood in India and Its Role in Conservation of Natural Populations -- Chapter 3. Sandalwood: Traditional Knowledge from Ayurveda -- Chapter 4. Genomic Resources in Indian Sandalwood: Implications in Conservation and Breeding -- Chapter 5. Whole Genome Sequence of Sandalwood and Its Comparative Study -- Chapter 6. Mining of SSRs and SNPs in Sandalwood Genome -- Chapter 7. Sandalwood Fragrance Pathway and Its Engineering for Sustainable Production of High-Value Santalols -- Chapter 8. Sandalwood Essential Oil and Its Phyto-Chemistry -- Chapter 9. Scope of Proteogenomic Analysis for Indian Sandalwood (Santalum album) -- Chapter 10. Future Prospects of Sandalwood Research.
    Abstract: This book is the first comprehensive compilation describing the importance of sandalwood in national and international markets, genetic resources, molecular markers, whole genome sequencing, and pathway genes involved in oil biosynthesis, aroma and fragrance. Application of various “omics” approaches in delineating genome architecture and annotation of genes is highlighted. This book comprises 10 chapters covered over 200 pages authored by the researchers involved in sandalwood genomics. The sandalwood, Santalum album is known for its unique fragrance and finest wood available for carving. Also, sandalwood is intertwined with Indian culture and it is the second most valuable and expensive tree in the world.
    Type of Medium: Online Resource
    Pages: XVIII, 103 p. 26 illus., 16 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030933944
    Series Statement: Compendium of Plant Genomes,
    DDC: 581.35
    Language: English
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  • 25
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Drugs Design. ; Pharmaceutical chemistry. ; Genomics. ; Bioinformatics. ; Biomedical Research. ; Structure-Based Drug Design. ; Pharmaceutics. ; Genomics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Emerging Technologies : Gateway to Understand Molecular Insight of Diseases, Newer Drugs, Their Design and Targeting -- Chapter 2. Polypharmacology: New Paradigms in Drug Development -- Chapter 3. Drug Repurposing in Biomedical Research : Benefits and Challenges -- Chapter 4. Computational Methods for Drug Repurposing -- Chapter 5. Genomic Approaches for Drug Repositioning -- Chapter 6. Organ-On-A- Chip: Novel in-Vitro Model For Drug Discovery -- Chapter 7. Precision Radiomolecular Oncology: Challenging the Classical Statistical Evidence Based Medicine -- Chapter 8. Drug Repositioning of the Phenylpiperazine Derivative Naftopidil in Prostate Cancer Treatment -- Chapter 9. Biomarker Based Drug Discovery and Reverse Translational Approach -- Chapter 10. Nanotechnology in Dentistry -- Chapter 11. Nanoparticles a Potential Breakthrough in Counteracting Multidrug-Resistant Bacterial Infections: A Holistic View on Underlying Mechanisms and Antibacterial Properties -- Chapter 12. Emerging Role of Cannabinoid System Modulators in Treatment of Cancer -- Chapter 13. Nanodrugs : A Futuristic Approach for Treating Nephrolithiasis -- Chapter 14. Lipo Dermaceuticals : Technological Transformation -- Chapter 15. The Importance of Drug Dose Adjustment in Elderly Patients with Special Considerations for Patients on Diverse Co-Medications and Antidepressants -- Chapter 16. Role of Microfluidics and Nano Fluidics in Managing CAD -- Chapter 17. Targeted Gene Delivery Through Magnetofection: The New Face of Medicine -- Chapter 18. Qbd-Steered Systematic Development of Drug Delivery Nanoconstructs : Vital Precepts, Retrospect and Prospects -- Chapter 19. Nanoemulsions: A Potential Advanced Nanocarrier Platform for Herbal Drug Delivery -- Chapter 20. Sirna Encapsulated Nanoparticles for Targeting Dorsal Root Ganglion (Drg) in Diabetic Neuropathic Pain -- Chapter 21. EGFR Targeted Quinazoline Clubbed Heterocycles as Anti-Cancer Agents. Chapter 22. Therapeutic Human Monoclonal Antibodies -- Chapter 23. Hydroxyapatites and Their Biomedical Applications -- Chapter 24. Recent Progress in Applications of Magnetic Nanoparticles in Medicine: A Review -- Chapter 25. Chimeric Antigen Receptor T-Cell Therapy: A Cutting Edge Therapy for Multiple Myeloma -- Chapter 26. Nanoparticles-Associated Lipopeptides: A New Class of Antimicrobials -- Chapter 27. Antimicrobial Applications of Engineered Metal-Based Nanomaterials -- Chapter 28. Strengthening Immunity-Ayurveda & Medicinal Plants -- Chapter 29. The Pathophysiology of Liver Disorders and Pharmacotherapy Options with Special Reference to Traditional Herbal Medicines: A Comprehensive Review -- Chapter 30. Polymeric Vehicles for Controlled Delivery of Ayurvedic Drugs for Wound Management.
    Abstract: This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.
    Type of Medium: Online Resource
    Pages: XII, 599 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811692321
    DDC: 610.72
    Language: English
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  • 26
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Genetics. ; Genetic transcription. ; Molecular biology. ; Bioinformatics. ; Genetics and Genomics. ; Gene Transcription. ; Molecular Biology. ; Bioinformatics.
    Description / Table of Contents: 1. What is the transcriptome and how it is evaluated? -- 2. ALTERNATIVE SPLICING OF PRE-MESSENGER RNA -- 3. Transcriptome Analysis Using RNA-seq and scRNA-seq -- 4. TRANSCRIPTOMICS OF NEONATAL AND INFANT HUMAN THYMUS -- 5. Transcriptomics at the single cell level and human diseases: opportunities and challenges in data processing and analysis -- 6. METHODS FOR GENE CO-EXPRESSION NETWORK VISUALIZATION AND ANALYSIS -- 7. Comparative Analysis of Packages and Algorithms for the Analysis of Spatially Resolved Transcriptomics Data -- 8. The Interplay Between the Transcriptomics and Proteomics Profiles -- 9. TRANSCRIPTOME DURING NORMAL CELL DIFFERENTIATION -- 10. Transcriptomics to dissect the Immune System -- 11. Transcriptome Profiling in Autoimmune Diseases -- 12. Transcriptome Profiling in Experimental Inflammatory Arthritis -- 13. TRANSCRIPTOMICS AND IMMUNE RESPONSE IN HUMAN CANCER -- 14. MicroRNAs in Cancer -- 15. Oxidative Stress, DNA Damage and Transcriptional Expression of DNA Repair and Stress Response Genes in Diabetes Mellitus -- 16. Large-scale gene expression in monogenic and complex genetic diseases -- 17. Transcriptome in Human Mycoses -- 18. Understanding Chagas Disease by Multi-omics data Integration, Functional and Enrichment Computational Analysis.
    Abstract: The study of transcriptomics is key to understanding complex diseases. This new edition will build on the foundation of the first edition while incorporating the progress that has been made in the field of transcriptomics in the past six years, including bioinformatics for data analysis. Written by leading experts, chapters address new subjects such as methodological advances in large-scale sequencing, the sequencing of single-cells, and spatial transcriptomics. The new edition will address how transcriptomics may be used in combination with genetic strategies to identify causative genes in monogenic and complex genetic diseases. Coverage will also explore transcriptomics in challenging groups of diseases, such as cancer, inflammation, bacterial infection, and autoimmune diseases. The updated volume will be useful for geneticists, genome biologists, biomedical researchers, molecular biologists, bioinformaticians, and students, among others.
    Type of Medium: Online Resource
    Pages: XI, 474 p. 67 illus., 62 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030878214
    DDC: 576.5
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Stratification of patients with Chronic Obstructive Pulmonary Disease using Volatile Organic Compounds -- 2-Evidence-based Leadership: A Study of its Application to General Hospital of the Public Health System through the Implementation Leadership Scale -- 3-Greek nurses’ perception of hospital ethical climate. A cross-sectional study -- 4-Investigating the main causes of conflicts and the managements strategies are used by healthcare professionals. The case of general hospital of Arta -- 5-Incidence of deep vein thrombosis and its effect on health related quality of life among nurses of Greek public hospital. A multicenter study -- 6-Factors affecting anxiety and depression in caregivers of hemodialysis patients -- 7-Hand grip strength in patients on hemodialysis: An observational study -- 8-The effect of spirituality on illness perceptions in patients undergoing hemodialysis -- 9-Validation of the STOP-Bang Questionnaire in Greek patients suffering from obstructive sleep apnea -- 10-The role of Pythagorean Self-Awareness Intervention in obstructive sleep apnea. A randomized controlled trial -- 11-Tissue characterization in Cardiology. Moving beyond function -- 12-Psychiatric care in acute care units with locked doors: Nursing care providers’ perceptions and experiences -- 13-Researching nursing students’ attitudes towards mental health practice: cultural adaptation and validation of the Greek version of the Acceptability of Locking the Door Questionnaire in acute psychiatric care -- 14-Compliance of bronchial asthma patients' with the Mediterranean diet -- 15-Nurses’ experiences of psychiatric care in acute care units with an open door policy -- 16-Validation of the Greek Version of Hedonic, Eudaimonic and Extrinsic Motives for Activities (HEEMA) Instrument -- 17-Event-Related Rumination Inventory: A Validation Process in the Greek Language -- 18-The job rotation of nursing staff and its effects on nurse`s satisfaction and occupational engagement -- 19-The burden on carers with multiple sclerosis -- 20-Attitudes of the general population regarding patient information for a chronic and life-threatening disease. A cross-sectional study -- 21-Assessment of healthcare professionals’ knowledge and awareness on aspects related to ionizing radiation examinations in Athens, Greece -- 22-Medication errors and their correlation with nurse's satisfaction. The case of the hospitals of Lasithi, Crete -- 23-Health-Related Quality of Life and Living Costs of HIV-Infected Patients -- 24-Evaluation of anxiety and depression in women undergoing mastectomy in Greece -- 25-The effect of emotional intelligence on caring behaviors among psychiatric nurses in Greece -- 26-Investigating nursing leadership in intensive care units of hospitals of Northern Greece and its relationship to the working environment -- 27-Health-Related Quality of Life and Rehabilitation Costs of Patients with Amputated Limb -- 28-Anxiety and depression in hemodialysis: Sex differences -- 29-Patient knowledge, adherence to the therapeutic regimen, and quality of life in hemodialysis -- 30-The burden of caregivers of patients after hip replacement and its impact on the cost of living of the family -- 31-The effects of exercise in patients with Sarcopenia -- 32-Fluid dynamics derived parameters in coronary vessels -- 33-Level of knowledge about COPD among patients and caregivers -- 34-Increased body mass index (BMI) and sunscreen use are associated with inadequate vitamin D status in Greek adults in winter -- 35-The effect of whole-body cryostimulation in healthy adults -- 36-Exhaled Nitric Oxide (FeNO) in patients hospitalized for an exacerbation of bronchiectasis and/or COPD -- 37-Formulation and Evaluation of Dermatological product containing Niacinamide -- 38-Exhaled breath condensate and dyspnea in COPD -- 39-The Effects of Pythagorean Self-Awareness Intervention on Irritable Bowel Syndrome Patients: A Non-Randomized Controlled Trial -- 40-Adults’ stress response to unexpected oral and arithmetic tasks in supine position -- 41-Triangles and family engagement in drug and alcohol addiction treatment -- 42-Use of fortified bread for addressing vitamin D deficiency. .
    Abstract: The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The increase in the average length of life leads to the development of various diseases in the elderly population. This volume focuses on the sessions from the conference on Geriatrics.
    Type of Medium: Online Resource
    Pages: XXVII, 389 p. 27 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030787714
    Series Statement: Advances in Experimental Medicine and Biology, 1337
    DDC: 616.042
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biometry. ; Biomedical engineering. ; Bioinformatics. ; Biological models. ; Biostatistics. ; Biomedical Engineering and Bioengineering. ; Computational and Systems Biology. ; Biological Models.
    Description / Table of Contents: Forecasting of SARS-COV-2 dynamic: beyond the classical SIR model -- Derivation of OED methods for applications in cytogenetic biodosimetry -- Minimum Phi-divergence tests for ophthalmological data grouped in clusters -- Multimodality test for determining which genes distinguish oncological patients -- Exploring the relationship between different cancer sites using disease mapping models -- Advances in flow cytometry gating based on distances and divergences in probability spaces -- Application of quantile regression models for biomedical data -- Hippocampus shape analysis via skeletal models and kernel smoothing -- Methods for analysis of microbiome count data with applications -- The FMM model as a classifier of cardiovascular pathologies -- A novel statistical insight of the circadian markers that govern cardiac rhythms -- Sleep and circadian synchronization assessment from multivariate recordings. .
    Abstract: This book presents novel statistics methods and reproducible software that helps to solve challenging problems in biomedicine. Specifically, it consists of a collection of 11 chapters contributed by some of the leading experts in the mathematical and statistical field which address new challenges in very disparate biomedical areas, such as genomics, cancer, circadian biology, microbiome, mental disorders, and more. The mathematical rigor is written in a user-friendly way to serve a general biomedical audience ranging from trainees or students to doctors, as well as scientific researchers, university departments, and PhD students.
    Type of Medium: Online Resource
    Pages: XI, 276 p. 71 illus., 57 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031327292
    DDC: 570.15195
    Language: English
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    Keywords: Animal culture. ; Veterinary medicine. ; Anatomy, Comparative. ; Genetics. ; Bioinformatics. ; Animal Science. ; Veterinary Science. ; Animal Anatomy. ; Genetics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1_Global Duck Production: An Overview -- Chapter 2_Breeds of Domestic Ducks -- Chapter 3_Duck Genetics and Breeding-Chapter 4_Anatomy and Physiology of Ducks -- Chapter 5_Nomadic (Transhumant) Duck Rearing -- Chapter 6_Integrated Duck Farming -- Chapter 7_Intensive Duck Rearing -- Chapter 8_Feeding and Nutrient Requirements of Ducks -- Chapter 9_Incubation and Hatching of Duck Eggs -- Chapter 10_Nutritive Value of Duck Meat and Eggs -- Chapter 11_Duck Slaughter Processing, Meat Quality Measurements and Value Addition -- Chapter 12_Duck Meat and Egg Products in Different Cuisines -- Chapter 13_Value Addition of Feather and Down -- Chapter 14_Duck Diseases & Disease Management -- Chapter 15_Duck Genomics and Biotechnology -- Chapter 16_ Duck Farming: Constraints and Recommendations.
    Abstract: This book provides comprehensive insights into the field of duck production and management. It presents a complete overview of different aspects of duck production with particular emphasis on rearing systems. The book reviews current knowledge on the anatomy, physiology, genetics, breeding, nutrition, incubation, and hatching practices of ducks. It further discusses the common diseases of duck, their treatment regime, and prevention strategies. The book additionally examines all aspects of the global duck industry, the constraints, and the recommendations. It also explores nutrient requirements and feed evaluation for duck and evaluates nutrition's influence on the gut microbiome. Towards the end, the book presents the latest genomic applications, including high throughput sequencing and various bioinformatics tools in duck production. This book serves as an essential resource for duck industry practitioners, researchers, and students.
    Type of Medium: Online Resource
    Pages: XVI, 657 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811661006
    DDC: 636
    Language: English
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    Keywords: Microbial ecology. ; Bacteria. ; Microbiology. ; Plant diseases. ; Bioinformatics. ; Microbial Ecology. ; Bacteria. ; Microbiology. ; Plant Pathology. ; Computational and Systems Biology.
    Description / Table of Contents: Chapter 1. Rhizosphere Metagenomics – Methods and Challenges -- Chapter 2. Metagenomic Approach in Relation to Plant-Microbe and Microbe-Microbe Interactions -- Chapter 3. Metagenomics and metatranscriptomics approaches in understanding and discovering novel molecules in rhizosphere environment -- Chapter 4. "Omics” approaches for understanding soil suppressiveness in agriculture -- Chapter 5. Rhizosphere dynamics: an OMICS perspective -- Chapter 6. Transcriptomics analyses and the relationship between plant and plant growth-promoting rhizobacteria (PGPR) -- Chapter 7. Proteomics for understanding the interaction between plant and rhizospheric microflora -- Chapter 8. A proteomics perspective for understanding rhizosphere biology at higher altitudes -- Chapter 9. Structural and functional rhizospheric microbial diversity analysis by cutting edge biotechnological tools -- Chapter 10. Rhizosphere Fingerprints: Novel Biomolecules via Meta-Omics Technology -- Chapter 11. Rhizosphere virology and plant health -- Chapter 12. Long sequencing tools for rhizosphere study -- Chapter 13. Rhizoengineering: A strategy to enhance soil and crop productivity -- Chapter 14. Endospheric microbiome assisted alteration in the metabolomic profiling of host towards abiotic stress mitigation. .
    Abstract: This book presents a timely review of the latest advances in rhizosphere biology, which have been facilitated by the application of omics tools. It includes chapters on the use of various omics tools in rhizosphere biology, focusing on understanding plant and soil microbe interactions. The role of proteomics and metagenomics in research on symbiotic association is also discussed in detail. The book also includes chapters on the use of omics tools for the isolation of functional biomolecules from rhizospheric microorganisms. The book’s respective sections describe and provide detailed information on important omics tools, such as genomics, transcriptomics, proteomics, metabolomics and meta-epigenomics. In turn, the book promotes and describes the combined use of plant biology, microbial ecology, and soil sciences to design new research strategies and innovative methods in soil biology. Lastly, it highlights the considerable potential of the rhizosphere in terms of crop productivity, bioremediation, ecological engineering, plant nutrition and health, as well as plant adaptation to stress conditions. This book offers both a practical guide and reference source for all scientists working in soil biology, plant pathology, etc. It will also benefit students studying soil microbiology, and researchers studying rhizosphere structure. .
    Type of Medium: Online Resource
    Pages: XIII, 279 p. 24 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811608896
    Series Statement: Rhizosphere Biology,
    DDC: 579.17
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Biomathematics. ; Biochemistry. ; Biology Technique. ; Biophysics. ; Computational and Systems Biology. ; Mathematical and Computational Biology. ; Bioinformatics. ; Biochemistry. ; Biophysical Methods.
    Description / Table of Contents: 1. Introduction to graph theory -- 2. Biological networks -- 3. Network inference for drug discovery- 4. Introduction to differential and integral calculus -- 5. Modelling chemical reactions -- 6. Reaction-diffusion systems -- 7. Linear algebra background -- 8. Regression -- 9. Cardiac electrophysiology -- .
    Abstract: This introductory guide provides a thorough explanation of the mathematics and algorithms used in standard data analysis techniques within systems biology, biochemistry, and biophysics. Each part of the book covers the mathematical background and practical applications of a given technique. Readers will gain an understanding of the mathematical and algorithmic steps needed to use these software tools appropriately and effectively, as well how to assess their specific circumstance and choose the optimal method and technology. Ideal for students planning for a career in research, early-career researchers, and established scientists undertaking interdiscplinary research. .
    Type of Medium: Online Resource
    Pages: X, 264 p. 40 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031365669
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 570.285
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Bioinformatics. ; Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Bioinformatics.
    Description / Table of Contents: Brain Tissue Oxygen and BOLD fMRI Under Different Levels Of Neuronal Activity -- Cerebral Microcirculation and Oxygenation Modulation by Transcranial Alternating Current Stimulation in Awake and Anesthetized Mice -- The Effect of Hypercapnia on Cortical Metabolic Rate and Mitochondrial Redox Status -- Relationship Between Left-Right Dominancy of Prefrontal Cortex Activity and Heart Rate During Rest and Task Periods: An fNIRS Study -- Relationship Between Cognitive Function, Oral Conditions and Systemic Metabolic Function in the Elderly -- Pro-survival Phenotype of HIF-1α: Neuroprotection through Inflammatory Mechanisms -- Infradian Rhythms in Cerebrovascular Oxygenation and Blood Volume in Humans at Rest: A 5-year Study -- Mechanisms of Photostimulation of Brain’s Waste Disposal System: the Role of Singlet Oxygen -- Changes of Arterial and Venous Cerebral Blood Flow Correlation in Moderate-to-Severe Traumatic Brain Injury: A CT Perfusion Study -- Cerebral Net Water Uptake in Posttraumatic Cerebral Ischemia -- Brainstem Damage Underlies Changes in Hypoxic Ventilatory Response following Cardiac Arrest and Resuscitation in Rats -- Differences Between Good, Moderate and Poor Performers of a Verbal Fluency Task under Blue Light Exposure: An SPA-fNIRS Study -- Sex-specific and Dose-dependent Effects of Drag-Reducing Polymers on Microcirculation and Tissue Oxygenation in Rats after Traumatic Brain Injury -- Accuracy of Tissue Oxygen Saturation Measurements of a Textile-based NIRS Sensor -- Understanding the Role of Caveolae in Oxygen Buffering: The Effect of Membrane Curvature -- The Significance of Lipids for the Absorption and Release of Oxygen in Biological Organisms -- How Skin Color Depends on Tissue Oxygenation -- Tissue Concentration Analysis of Sulfur, Calcium and Oxygen in novel Skin Primo Nodes After Acupuncture -- Primo Vessels Inside Lymphatic Vessels are Absent in an ALS Mouse Model -- The Impact of Heterogeneous Cell Density in Hypoxic Tumors Treated with Radiotherapy -- A Critical Analysis of Possible Mechanisms for the Oxygen Effect in Radiation Therapy with FLASH -- Hyperhydration of Cancers: A Characteristic Biophysical Trait Strongly Increasing O2, CO2, Glucose and Lactate Diffusivities, and Improving Thermophysical Properties of Solid Malignancies -- No Difference in Muscle Basal Oxygenation in a Bedridden Population pre and Post Rehabilitation -- Relationship between Muscle Deoxygenation and Cardiac Output in Subjects without Attenuation of Deoxygenation Hemoglobin Concentration near the end of Ramp Cycling Exercise: A Longitudinal Study -- Image Reconstruction Using Deep Learning for Near-Infrared Optical Tomography: Generalization Assessment -- Neonatal Brain Temperature Monitoring Based on Broadband Near-Infrared Spectroscopy -- Time Domain Near-Infrared Optical Tomography Utilizing Full Temporal Data: A Simulation Study -- BIAN: A Multilayer Microfluidic-Based Tissue-Mimicking Phantom for Near-Infrared Imaging -- Do Vascular and Extracellular Measurements Consistently Reflect Intracellular pO2? Observation of Tissue Oxygenation Changes using Remote Photoplesysmography with a Smartphone -- Neurovascular, Metabolic, and Glymphatic Dynamics of the Brain Measured with fNIRS -- Imaging Cerebral Blood Vessels Using Near-Infrared Optical Tomography: A Simulation Study -- Reduced Cerebrovascular Oxygenation in Individuals with Post-Acute COVID-19 Syndrome (PACS) (“Long COVID”) -- Insufficient Oxygen Supplementation During Cardiopulmonary Resuscitation Leads to Unfavorable Biological Response While Hyperoxygenation Contributes to Metabolic Compensation -- Block of the Angiotensin Pathways Affects Flow-Volume Spirometry in Patients With SARS-CoV-2 Infection -- A Prospective Observational Pilot Study on the Effects of the Activity-based Stress Release Program on the Mental State and Autonomic Nervous System in Psychiatric patients. .
    Abstract: This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 49th annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2022). Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource.
    Type of Medium: Online Resource
    Pages: XIX, 240 p. 91 illus., 71 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031420030
    Series Statement: Advances in Experimental Medicine and Biology, 1438
    DDC: 571.6
    Language: English
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    Keywords: Invertebrates. ; Animal culture. ; Physiology. ; Biodiversity. ; Freshwater ecology. ; Marine ecology. ; Bioinformatics. ; Invertebrate Zoology. ; Animal Science. ; Animal Physiology. ; Biodiversity. ; Freshwater and Marine Ecology. ; Computational and Systems Biology.
    Description / Table of Contents: Chapter 1. An Introduction to the Dytiscidae: Their Diversity, Historical Importance, Cultural Significance, and Other Musings -- Chapter 2. Larval Chaetotaxy of World Dytiscidae (Coleoptera: Adephaga) and Implications for the Study of Hydradephaga -- Chapter 3. The Phylogeny and Classification of Predaceous Diving Beetles (Coleoptera: Dytiscidae) -- Chapter 4. Predaceous Diving Beetle Sexual Systems -- Chapter 5. Morphology, Anatomy, and Physiological Aspects of Dytiscids -- Chapter 6. Chemical Ecology and Biochemistry of Dytiscidae -- Chapter 7. Community Patterns in Dytiscids -- Chapter 8. Predator-Prey Ecology of Dytiscids -- Chapter 9. The Unique Australian Subterranean Dytiscidae: Diversity, Biology, and Evolution -- Chapter 10. Habitats Supporting Dytiscid Life -- Chapter 11. Dispersal in Dytiscidae -- Chapter 12. The Conservation of Predaceous Diving Beetles: Knowns, Unknowns and Anecdotes.
    Abstract: The 2nd edition of this comprehensive book provides one of the most complete overviews of the aquatic beetles in the family Dytiscidae, also known as predaceous diving beetles. Dytiscids constitute one of the largest families of freshwater insects with approximately 4,650 named species that come in a variety of sizes, colors, and habitat affinities. Although dytiscid adults and larvae are ubiquitous throughout a variety of aquatic habitats, and are important predators on other aquatic invertebrates and vertebrates, there are no compilations that have focused on summarizing the knowledge on aspects of their ecology, systematics, and biology. Chapters in this book summarize hitherto scattered topics, including their anatomy and habitats, chemical and community ecology, phylogenies and larval morphology including chaetotaxy, sexual systems, predation, dispersal, conservation, and cultural and historical aspects. The 2nd edition offers updates on the newest scientific findings on dytiscids and also includes a new chapter on the subterranean fauna from Australia. The information in this new edition is potentially beneficial to anyone working in aquatic systems where dytiscids are an important part of the food web. Moreover, readers will gain a greater appreciation of dytiscids as model organisms for investigations of fundamental principles derived from ecological and evolutionary theory. Contributed chapters are by authors who are actively engaged in studying dytiscids, and each chapter provides color photos and future directions for research.
    Type of Medium: Online Resource
    Pages: XII, 573 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031012457
    DDC: 592
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Proteins . ; Proteins. ; Enzymology. ; Medical genetics. ; Bioinformatics. ; Protein Biochemistry. ; Proteins. ; Enzymology. ; Medical Genetics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Protein Purification, Estimation, Storage and Effect on Structure, Function and Dynamics -- Chapter 2. Experimental and Computational Methods to Determine Protein Structure and Stability -- Chapter 3. Wet-Lab Approaches to Determine Three-Dimensional Structures of Proteins -- Chapter 4. Use of Group Specific Reagents in Active Site Functional Group Elucidation I: Cys, Ser, Tyr and Trp Residues -- Chapter 5. Use of Group Specific Reagents in Active Site Functional Group Elucidation II: Asp, Glu, Arg, Lys and His residues -- Chapter 6. Protein-Protein Interactions Modeling: From Dry to Wet Lab -- Chapter 7. Thermodynamics of Protein-Ligand Binding -- Chapter 8. SynergisticEffects of Hydration Sites in Protein Stability: A Theoretical Water Thermodynamics Approach -- Chapter 9. Molecular Dynamics Simulation: Methods and Application -- Chapter 10. Protein Folding, Dynamics and Aggregation at Single Molecule Resolution -- Chapter 11. Protein Misfolding and Neurodegenerative Diseases -- Chapter 12. Management of Insulin Through Co-Solute Engineering: A Therapeutic Approach -- Chapter 13. Structural and Functional Aspects of Muscarinic Receptors in Correlation with Anticholinergic Drugs -- Chapter 14. Dopamine Β Hydroxylase: An Enzyme with Therapeutic Potential to Combat Neural and Cardiovascular Diseases -- Chapter 15. Molecular Motors: Subdomain Dynamics and Mechanochemistry -- Chapter 16. Structural and Functional Dynamics of Lysosomal Cysteine Proteases with Particular Reference to Cathepsin B and Cathepsin H -- Chapter 17. An Insight into the Importance of Ferritins in the Physiology of Mycobacterium tuberculosis: Unique Structural and Functional Properties.
    Abstract: This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances. Further, the book explains the current understanding on the therapeutic importance of the enzyme dopamine beta hydroxylase; structural dynamics and motions in molecular motors; role of cathepsins in controlling degradation of extracellular matrix during disease states; and the important structure-function relationship of iron-binding proteins, ferritins. Overall, the book is an important guide and a comprehensive resource for understanding protein structure, function, dynamics, and interaction.
    Type of Medium: Online Resource
    Pages: XII, 452 p. 71 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811555305
    DDC: 572.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Artificial intelligence. ; Bioinformatics. ; Biomedical Research. ; Artificial Intelligence. ; Bioinformatics.
    Description / Table of Contents: 1-Dimensional Convolution Neural Network Classification Technique for Gene Expression Data -- Classification of Sequences with Deep Artificial Neural Networks: Representation and Architectural Issues -- A Deep Learning Model for MicroRNA-Target Binding -- Recurrent Neural Networks Architectures for Accidental Fall Detection on Wearable Embedded Devices -- Medical Image Retrieval System using Deep Learning Techniques -- Medical Image Fusion using Deep Learning -- Deep Learning for Histopathological Image Analysis -- Innovative Deep Learning Approach for Biomedical Data Instantiation and Visualization -- Convolutional Neural Networks in Advanced Biomedical Imaging Applications -- Deep Learning for Lung Disease Detection from Chest X-Rays Images -- Deep Learning in Multi-Omics Data Integration in Cancer Diagnostic -- Using Deep Learning with Canadian Primary Care Data for Disease Diagnosis -- Brain Tumor Segmentation and Surveillance with Deep Artificial Neural Networks.
    Abstract: This book is the first overview on Deep Learning (DL) for biomedical data analysis. It surveys the most recent techniques and approaches in this field, with both a broad coverage and enough depth to be of practical use to working professionals. This book offers enough fundamental and technical information on these techniques, approaches and the related problems without overcrowding the reader's head. It presents the results of the latest investigations in the field of DL for biomedical data analysis. The techniques and approaches presented in this book deal with the most important and/or the newest topics encountered in this field. They combine fundamental theory of Artificial Intelligence (AI), Machine Learning (ML) and DL with practical applications in Biology and Medicine. Certainly, the list of topics covered in this book is not exhaustive but these topics will shed light on the implications of the presented techniques and approaches on other topics in biomedical data analysis. The book finds a balance between theoretical and practical coverage of a wide range of issues in the field of biomedical data analysis, thanks to DL. The few published books on DL for biomedical data analysis either focus on specific topics or lack technical depth. The chapters presented in this book were selected for quality and relevance. The book also presents experiments that provide qualitative and quantitative overviews in the field of biomedical data analysis. The reader will require some familiarity with AI, ML and DL and will learn about techniques and approaches that deal with the most important and/or the newest topics encountered in the field of DL for biomedical data analysis. He/she will discover both the fundamentals behind DL techniques and approaches, and their applications on biomedical data. This book can also serve as a reference book for graduate courses in Bioinformatics, AI, ML and DL. The book aims not only at professional researchers and practitioners but also graduate students, senior undergraduate students and young researchers. This book will certainly show the way to new techniques and approaches to make new discoveries.
    Type of Medium: Online Resource
    Pages: VI, 359 p. 130 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030716769
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Cytology. ; Bioinformatics. ; Biology Technique. ; Biotechnology. ; Cell Biology. ; Computational and Systems Biology. ; Biological Techniques.
    Description / Table of Contents: Workflows and Components of Bioimage Analysis -- Measurements of Intensity Dynamics at the Periphery of the Nucleus -- 3D Quantitative Colocalisation Analysis -- The NEMO Dots Assembly: Single-Particle Tracking and Analysis -- Introduction to MATLAB: Image Analysis & Brownian Motion -- Resolving the process of Clathrin Mediated Endocytosis Using Correlative Light & Electron Microscopy (CLEM).
    Abstract: This Open Access textbook provides students and researchers in the life sciences with essential practical information on how to quantitatively analyze data images. It refrains from focusing on theory, and instead uses practical examples and step-by step protocols to familiarize readers with the most commonly used image processing and analysis platforms such as ImageJ, MatLab and Python. Besides gaining knowhow on algorithm usage, readers will learn how to create an analysis pipeline by scripting language; these skills are important in order to document reproducible image analysis workflows. The textbook is chiefly intended for advanced undergraduates in the life sciences and biomedicine without a theoretical background in data analysis, as well as for postdocs, staff scientists and faculty members who need to perform regular quantitative analyses of microscopy images.
    Type of Medium: Online Resource
    Pages: X, 170 p. 69 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030223861
    Series Statement: Learning Materials in Biosciences,
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Agriculture. ; Environmental monitoring. ; Computer-aided engineering. ; Bioinformatics. ; Computer simulation. ; Agriculture. ; Environmental Monitoring. ; Computer-Aided Engineering (CAD, CAE) and Design. ; Computational and Systems Biology. ; Computer Modelling.
    Description / Table of Contents: Section I - MODELLING IN WEED SCIENCE -- Chapter 1 - Mathematical models -- Chapter 2 - Decision Support Systems in Weed Science -- Chapter 3 - Optimization in DSS -- Section II - BIO-ECOLOGICAL MODELS -- Chapter 4 - Population-based models -- Chapter 5 - Weed germination and dormancy models -- Chapter 6 - Field Emergence models -- Chapter 7 - Interference/Competition models -- Chapter 8 - Herbicide resistance modelling -- Section III - ENVIRONMENTAL RISK MODELLING -- Chapter 9 - Theory and practice for environmental risk assessment of weed management systems -- Chapter 10 - Environmental risk indicators for weed management assessment: a case study of ecotoxicity risk using fuzzy logic -- Chapter 11 - DRASTIC GIS-based models: assessing the vulnerability of groundwater resources -- Section IV - WEED MANAGEMENT DECISION SUPPORT SYSTEMS: STUDY CASES -- Chapter 12 - FLORSYS model: How to use a virtual field to evaluate and design IWM strategies at different spatial and temporal scales -- Chapter 13 - Ryegrass Integrated Management (RIM)-based DSS -- Chapter 14 - CPOweeds: DSS for multispecies weed control in cereals crops -- Chapter 15 - AVENA-NET/LOLIUM-NET: DSS for Avena sterilis and Lolium rigidum control in cereal crops -- Chapter 16 - AVESUD: DSS for Avena fatua control in winter cereal crop rotations -- Chapter 17 - DSS Perspectives, Challenges and Future work.
    Abstract: Weed management Decision Support Systems (DSS) are increasingly important computer-based tools for modern agriculture. Nowadays, extensive agriculture has become highly dependent on external inputs and both economic costs, as well the negative environmental impact of agricultural activities, demands knowledge-based technology for the optimization and protection of non-renewable resources. In this context, weed management strategies should aim to maximize economic profit by preserving and enhancing agricultural systems. Although previous contributions focusing on weed biology and weed management provide valuable insight on many aspects of weed species ecology and practical guides for weed control, no attempts have been made to highlight the forthcoming importance of DSS in weed management. This book is a first attempt to integrate 'concepts and practice' providing a novel guide to the state-of-art of DSS and the future prospects which hopefully would be of interest to higher-level students, academics and professionals in related areas.
    Type of Medium: Online Resource
    Pages: XII, 342 p. 86 illus., 60 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030444020
    DDC: 630
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Evolution (Biology). ; Bioinformatics. ; Evolutionary Biology. ; Computational and Systems Biology.
    Description / Table of Contents: Part I Problems -- 1 The Unix Command Line -- 1.1 Getting Started -- 1.2 Files, Directories, and Programs.-1.3 Scripts -- 2 Optimal Alignment -- 2.1 Keeping Score -- 2.2 Construction -- 2.3 Application -- 3 Exact Matching -- 3.1 Keyword Trees -- 3.2 Suffix Trees -- 3.3 Suffix Arrays -- 3.4 Text Compression -- 4 Fast Alignment -- 4.1 Global -- 4.2 Local -- 4.3 Glocal -- 4.4 Assembly -- 4.5 Multiple Sequences -- 5 Evolution Between Species: Phylogeny -- 5.1 Trees of Life -- 5.2 Rooted Trees -- 5.3 Unrooted Trees -- 6 Evolution within Populations -- 6.1 Descent from One or Two Parents -- 6.2 The Coalescent -- 7 Interrogating and Storing Data -- 7.1 Statistics -- 7.2 Relational Databases -- Part II Answers. -- 1 The Unix Command Line -- 1.1 Getting Started -- 1.2 Files, Directories, and Programs -- 1.3 Scripts -- 2 Optimal Alignment -- 2.1 Keeping Score -- 2.2 Construction -- 2.3 Application -- 3 Exact Matching -- 3.1 Keyword Trees -- 3.2 Suffix Trees -- 3.3 Suffix Arrays -- 3.4 Text Compression -- 4 Fast Alignment -- 4.1 Global -- 4.2 Local -- 4.3 Glocal -- 4.4 Assembly -- 4.5 Multiple Sequences -- 5 Evolution Between Species: Phylogeny -- 5.1 Trees of Life -- 5.2 Rooted Trees -- 5.3 Unrooted Trees -- 6 Evolution within Populations -- 6.1 Descent from One or Two Parents -- 6.2 The Coalescent -- 7 Interrogating and Storing Data -- 7.1 Statistics -- 7.2 Relational Databases -- A. Unix Guide -- B. Programs -- B.1 Own -- B.2 Biobox -- B.3 Third-Party -- References -- Index.
    Abstract: This self-contained textbook covers fundamental aspects of sequence analysis with special emphasis on evolutionary biology, including sequence alignment, exact matching, phylogeny reconstruction, and coalescent simulation. It addresses these topics through a series of over 800 computer problems, ranging from elementary to research level, to enable learning by doing. Students solve the problems in the same computational environment used for decades in science – the Unix command line. This is available on all four major operating systems for PCs: Windows, macOS, chromeOS, and Linux. To learn using this powerful system, students analyze sample sequence data by applying generic tools, bioinformatics software, and over 50 programs specifically written for this course and available via GitHub. The solutions for all problems are included, making the book ideal for self-study. Problems are grouped into sections headed by an introduction and a list of new terms. By using practical computing to explore sequence data in an evolutionary context, the book enables readers to tackle their own computational problems.
    Type of Medium: Online Resource
    Pages: IX, 411 p. 155 illus., 46 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031204142
    DDC: 570.285
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Telecommunication. ; User interfaces (Computer systems). ; Human-computer interaction. ; Application software. ; Industrial engineering. ; Production engineering. ; Computational and Systems Biology. ; Communications Engineering, Networks. ; User Interfaces and Human Computer Interaction. ; Computer and Information Systems Applications. ; Industrial and Production Engineering.
    Description / Table of Contents: Introduction -- Emerging Industrial Revolution -- IoT: What makes it different from the past revolutions -- World is changing -- Engineering: How It was developed so far -- Humans: Their characteristics -- Value is changing -- Adaptive team organization and management -- Integration of Physical Science and Life Science -- Summary.
    Abstract: .
    Type of Medium: Online Resource
    Pages: XI, 70 p. 44 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030515881
    Series Statement: SpringerBriefs in Applied Sciences and Technology,
    DDC: 570.285
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Industrial microbiology. ; Bioinformatics. ; Synthetic Biology. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Industrial Microbiology. ; Computational and Systems Biology. ; Synthetic Biology.
    Description / Table of Contents: Part 1 Introduction to Microbial Engineering -- 1 Exploring the Potential of Microbial Engineering: The Prospect, Promise and Essence -- Part 2 Microbial Engineering Approaches -- 2 Role of System Biology in Microbial System -- 3 Synthetic Biology: Refining Human Health -- 4 Probiotic Engineering: A focus on Inflammatory Bowel Disease -- 5 Engineering microbes for smart diagnostics & Lab on Chip -- 6 Bacteriophage and Virus Engineering -- 7 CRISPR Technologies: A tool for Engineering Microbes -- Part 3 Health Benefits -- 8 Recombinant Vaccines: The Revolution Ahead -- 9 Microbe-Host Metabolic Interaction- Probiotic Approach -- 10 Designer Microbes: Oncotherapy approach -- 11 The human gut microbiome in health, disease and therapeutics -- 12 Use of Engineered Bacteria for Production of Green Chemicals & Pharmaceuticals -- 13 Fat Fighting Microbes. Part 4 Innovation & Translation -- 14 Scale-up of engineering strain for industrial applications -- 15 Affordable therapeutics through Engineered Microbes -- 16 COVID-19: Lesson Learnt from Diagnostics to therapeutics. .
    Abstract: This book highlights the recent advances in the field of microbial engineering and its application in human healthcare. It underscores the systemic and synthetic biology approaches for engineering microbes and discusses novel treatments for inflammatory bowel diseases based on engineered probiotics. The book also reviews the different options and methods for engineering microbes, ranging from recombinant DNA technology to designing microbes for targeting specific sites and delivering therapeutics. Further, it discusses genetically engineered microorganisms for smart diagnostics and describes current approaches in microbial gene editing using CRISPR-Cas9-based tools. Lastly, it summarizes the potential applications of human microbiome engineering in improving human health and explores potential strategies for scaling-up the production of engineered microbial strains for commercial purposes, as well as the challenges. Given its scope, this book is a valuable resource for students, researchers, academics and entrepreneurs interested in understanding microbial engineering for the production of commercial products.
    Type of Medium: Online Resource
    Pages: XI, 374 p. 45 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811939792
    DDC: 610.72
    Language: English
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    Keywords: Cancer. ; Oncology. ; Medical genetics. ; Bioinformatics. ; Microtechnology. ; Microelectromechanical systems. ; Cancer Biology. ; Oncology. ; Medical Genetics. ; Bioinformatics. ; Microsystems and MEMS.
    Description / Table of Contents: Module 1_ Introduction -- Module 2_ Cancer Metastasis -- Module 3_ Role of Transcriptomics in cancer treatment strategies -- Module 4_Computational approaches -- Module 5_Biostatistics and clinical oncology -- Module 6_Pharmacogenomics in cancer -- Chapter 7_Case studies.
    Abstract: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
    Type of Medium: Online Resource
    Pages: XVIII, 499 p. 59 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811510670
    DDC: 571.978
    Language: English
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    Keywords: Plant diseases. ; Bioinformatics. ; Invertebrates. ; Plant Pathology. ; Computational and Systems Biology. ; Bioinformatics. ; Invertebrate Zoology.
    Description / Table of Contents: Chapter 1. Application of Geospatial Technologies in Plant Health Management -- Chapter 2. Applications of Unmanned Aerial System for Pest Surveillance, Monitoring and Management -- Chapter 3. Unmanned Aerial System Technologies for Pesticide Spraying -- Chapter 4. Insect Pest Detection, Migration and Monitoring Using Radar and LiDAR Systems -- Chapter 5. Remote Sensing, Climate Change and Insect Pest: Can Biotic Interactions be Explored? -- Chapter 6. Use of Mobile Apps and Software Systems for Retrieving and Disseminating Information on Pest and Disease Management -- Chapter 7. Harnessing Host Plant Resistance for major crop pests: Decoding In-Built Systems -- Chapter 8. Light Trap: A Dynamic Tool for Data Analysis, Documenting and Monitoring Insect Populations and Diversity -- Chapter 9. Artificial Diet Designing: Its Utility in Management of Defoliating Tea Pests (Lepidoptera: Geometridae) -- Chapter 10. Functional Diversity of Infochemicals in Agri-ecological Networks -- Chapter 11. Soil Fauna In Sustainable Agriculture -- Chapter 12. Pest Management in Tropical Forests -- Chapter 13. Non-Chemical Pest Management Approaches in Tea Ecosystem: Evading Pesticide Trap -- Chapter 14. Endophytes: A Potential Bio-agent for the Plant Protection -- Chapter 15. Insect Vectors of Phytoplasma Diseases in the Tropics: Molecular Biology and Sustainable Management -- Chapter 16. Hymenopteran Parasitoids in Cultivated Ecosystems: Enhancing Efficiency -- Chapter 17. Large Scale Production of Cotton Bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) Nuclear Polyhedrosis Virus (HaNPV) -- Chapter 18. Insecticide Toxicity and Pesticide Residues in Horticultural Crops -- Chapter 19. Nano-technology Applications in Pest Management -- Chapter 20. Integrated and Ecological based Pest Management in Grape Ecosystem -- Chapter 21. Coccinellids on Crops: Nature’s Gift for Farmers -- Chapter 22. Scenario of Insect Pests on Litchi: Management Options -- Chapter 23. IPM in Protected Cultivation: Lending Pesticide Free Produce -- Chapter 24. Integrated Nematode Management In Protected Cultivation.
    Abstract: Several Integrated Pest Management (IPM) approaches are available for managing pests of varied kinds, including individual and integrated methods for pest suppression. Recently the focus has shifted to pest management tools that act on insect systems selectively, are compatible with the environment, and are not harmful for ecosystems. Other approaches target specific biochemical and physiological aspects of insect metabolism, and involve biotechnological and genetic manipulation. Still other approaches include the use of nanotechnology, endophytes, optical and sonic manipulation to detect and control pest insects. Unfortunately, conventional forms of pest management do not focus on technology transfer to the ground level workers and farmers. As a result, farmers are incurring huge losses of crops and revenues. This book highlights the importance of using communication tools in pest management and demonstrates some success stories of utilizing automated unmanned technologies in this context. The content is divided into three sections, the first of which, “Pest Population Monitoring: Modern Tools,” covers long and short-range pest population monitoring techniques and tools such as satellites, unmanned aerial vehicles/drones, remote sensing, digital tools like GIS, GPS for mapping, lidar, mobile apps, software systems, artificial diet designs and functional diversity of info-chemicals. The second section of the book is devoted to “Emerging Areas in Pest Management” and offers a glimpse of diversified tactics that have been developed to contain and suppress pest populations such as endophytes, insect vectors of phytoplasma, Hymenopterans parasitoids, mass production and utilization of NPV etc. In turn, the third section focuses on “Integrated Pest Management” and presents farming situations that illustrate how research in diversified aspects has helped to find solutions to specific pest problems, and how some new and evolving tactics can be practically implemented. Given its scope, the book offers a valuable asset for entomology and plant pathology researchers, students of zoology and plant protection, and readers whose work involves agriculture, horticulture, forestry and other ecosystems. .
    Type of Medium: Online Resource
    Pages: XIX, 519 p. 233 illus., 145 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811507946
    DDC: 571.92
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Conservation biology. ; Ecology . ; Animal culture. ; Vertebrates. ; Bioinformatics. ; Anthropology. ; Conservation Biology. ; Animal Science. ; Vertebrate Zoology. ; Computational and Systems Biology. ; Anthropology.
    Description / Table of Contents: Tourism and Indonesia’s Primates: An Introduction- Similar Perceptions of National and International Volunteer Ecotourists Contribute to the Conservation of the Critically Endangered Javan Slow Loris in Java, Indonesia -- Bukit Lawang and Beyond: Primates and tourism from a provider’s perspective -- Rethinking Tolerance to Tourism: Behavioral responses by wild crested macaques (Macaca nigra) to tourists -- The Effect of Tourism on a Nocturnal Primate, Tarsius spectrum, in Indonesia -- Javan Gibbon Tourism: A Review from West and Central Java Initiatives -- Encountering Sulawesi’s Endemic Primates: Considerations for developing primate tourism in South Sulawesi, Indonesia -- Primates and Primatologists: Reflecting on two decades of primatological and ethnoprimatological research, tourism, and conservation at the Ubud Monkey Forest -- Primate tourism on Java: 40 years of ebony langur viewing in Pangandaran from homestay visits to mass tourism -- Indigenous Bird Ecotourism in Halmahera Island, Indonesia. .
    Abstract: The basic goal of the volume is to compile the most up to date research on the effect of ecotourism on Indonesia’s primates. The tremendous diversity of primates in Indonesia, in conjunction with the conservation issues facing the primates of this region, have created a crisis whereby many of Indonesia’s primates are threatened with extinction. Conservationists have developed the concept of “sustainable ecotourism” to fund conservation activities. National parks agencies worldwide receive as much as 84% of their funding from ecotourism. While ecotourism funds the majority of conservation activities, there have been very few studies that explore the effects of ecotourism on the habitat and species that they are designed to protect. It is the burgeoning use of “ecotourism” throughout Indonesia that has created a need for The Ecotourism of Indonesia's Primates where the successes and pitfalls at various sites can be identified and compared.
    Type of Medium: Online Resource
    Pages: VIII, 220 p. 48 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031149191
    Series Statement: Developments in Primatology: Progress and Prospects,
    DDC: 333.9516
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Cytology. ; Regenerative medicine. ; Medicine Research. ; Biology Research. ; Bioinformatics. ; Cell Biology. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Research. ; Bioinformatics.
    Description / Table of Contents: Involvement of Endothelial Nitric Oxide Synthase in Cerebral Microcirculation and Oxygenation in Traumatic Brain Injury -- Imaging cerebral energy metabolism in healthy infants -- Changes in cerebral oxygenation and systemic physiology during a verbal fluency task: Differences between men and women -- Brain Tissue Conductivity in Focal Cerebral Ischemia -- Physical stress Attenuates Cognitive inhibition: An fNIRS Examination -- Changes in Prefrontal Cortical Oxygenation During Tilt Table Orthostatic Hypotension in Subarachnoid Haemorrhage Patients -- Effects of different optical properties of head tissues on near-infrared spectroscopy Using Monte Carlo Simulations -- Frontal cerebral oxygenation in humans at rest: A mirror symmetry in the correlation with cardiorespiratory activity -- Photomodulation of lymphatic delivery of bevacizumab to the brain: the role of singlet oxygen -- NIRS-based study of local cerebral oxygenation during transcranial direct current stimulation in patients with mild traumatic brain injury -- Postnatal Exposure to Brief Hypoxia Alters Brain VEGF Expression and Capillary Density in Adult Mice -- Impaired Cognitive Performance in Mice Exposed to Prolonged Hyperoxia -- Chronic Ketosis Modulates HIF1α-Mediated Inflammatory Response in Rat Brain -- Motor Imagery and Frontal Head Oxygenation: An fNIRS Study -- Non-invasive detection of persistent cortical hypoxia in Multiple Sclerosis using frequency domain near-infrared spectroscopy (fdNIRS) -- Evaluation of intraoperative end-tidal Carbon dioxide change relates to length hospitalization in peridiaphragmatic surgery: a pilot study -- Pulmonary Embolism in COVID-19 patients is not related to a worsening in tissue oxygenation -- Cardiovascular risk score and gas exchange in COVID-19 patients: no correlation -- Heme Oxygenase 1/ High Mobility Group Box 1 pathway may have a possible role in Covid-19 ARDS (Acute respiratory distress syndrome): a pilot histological study -- Silent Hypoxemia in COVID-19 pneumonia -- Low Flow and Microvascular Shunts: A Final Common Pathway to Cerebrovascular Disease: A Working Hypothesis -- A case of intracranial vertebral artery stenosis treated with percutaneous transluminal angioplasty and stenting guided by brain oximetry -- Assessment of Optimal Arterial Pressure with Near-Infrared Spectroscopy in Traumatic Brain Injury Patients -- Effects of exercise-diet therapy on cognitive function in healthy elderly people evaluated by deep learning based on basic blood test data -- NIRS studies show reduced interhemispheric functional connectivity in individuals with Multiple Sclerosis that exhibit cortical hypoxia -- Eye Tracking Parameters Correlate With the Level of Cerebral Oxygen Saturation in Mild Traumatic Brain Injury: A Preliminary Study -- Critical closing pressure of cerebral circulation at concomitant moderate-to-severe traumatic brain injury -- Hybrid convolutional neural network (hCNN) for image reconstruction in near-infrared optical tomography -- Cross-frequency coupling between brain and body biosignals: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Machine learning distinguishes familiar from unfamiliar pairs of subjects performing an eye contact task: A systemic physiology augmented functional near-infrared spectroscopy hyperscanning study -- Assessing Neurovascular Coupling Using Wavelet Coherence in Neonates With Asphyxia -- Basic examination of hemoglobin phase of oxygenation and deoxygenation in resting state and task periods in adults using fNIRS -- Development and validation of robust and cost-effective liquid heterogeneous phantom for time domain near-infrared optical tomography -- Effect of Exercise Therapy on Stress Response Evaluated by IoMT Monitoring System -- Improved optical tissue model for tissue oximetry imaging applications -- In vitro validation of a new tissue oximeter using visible light -- Photon and Proton Dose Painting based on Oxygen Distribution – Feasibility Study and Tumour Control Probability Assessment -- Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells -- Feasibility of non-invasive measurement of tumor NAD(H) by in vivo phosphorus-31 magnetic resonance spectroscopy -- Acidosis-induced regulation of Egr1 and Ccn1 in vitro and in experimental tumors in vivo -- Perfusion-Limited Hypoxia Determines the Outcome of Radiation Therapy of Hypoxic Tumours -- Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers upon Mild Hyperthermia Delivered by wIRA-Irradiation -- Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy -- Optical Redox Imaging Is Responsive to TGFβ Receptor Signaling in Triple-Negative Breast Cancer Cells -- Evaluation of betulinic acid derivatives as PET tracers for hypoxia-induced carbonic anhydrase IX (CA IX) expression -- Role of the mTOR signaling pathway during extracellular acidosis in tumor cells -- Feasibility Study of Remote Contactless Perfusion Imaging with Consumer-Grade Mobile Camera -- Stability of a Novel PEGylation site on a Putative Hemoglobin Based Oxygen Carrier -- Oxygen storage in stacked phospholipid membranes under an oxygen gradient as a model for myelin sheaths -- Confocal laser and electron microscopic investigation of gap junctions in anaplastic astrocytomas -- A radiation biological analysis of the oxygen effect as a possible mechanism in FLASH -- Assessment of nicotinamide adenine dinucleotide in human tissues by in vivo phosphorus-31 magnetic resonance spectroscopic imaging at 1.5 Tesla -- Drag-Reducing Polymers Improve Vascular Hemodynamics and Tissue Oxygen Supply in Mouse Model of Diabetes Mellitus -- Hemorheologic Enhancement of Cerebral Perfusion increases oxygen supply and reduces Ab plaques deposition in a mouse model of Alzheimer’s Disease -- Calorimetric Characterization of the Binding Reaction Between Human Ferric Hemoglobins and Haptoglobin to Develop a Drug for Removal of Cell-Free Haemoglobin -- Feasibility To Measure Tissue Oxygen Saturation Using Textile-integrated Polymer Optical Fibers -- Effect of Atorvastatin on Microcirculation Evaluated by Vascular Occlusion Test with Peripheral Near lnfrared Spectroscop -- Flow characteristics of the conjugate of anti-CD3 monoclonal antibodies and magnetic nanoparticle in the PBS and the blood vessel -- Cerebrovascular Reserve (CVR) and Stages of Hemodynamic Compromise -- On the mechanism of sustained mitochondrial membrane potential without functioning complex IV -- Further evidence that gradients of extracellular pH direct migration of MDA-MB-231 cells in vitro -- Blood Flow and Respiratory Gas Exchange in the Human Placenta at Term: A Data Update -- Oxyhaemoglobin Level Measured Using Near-Infrared Spectrometer is Associated with Brain Mitochondrial Dysfunction After Cardiac Arrest in Rats -- Changes in Oxygenation Levels During Moderate Altitude Simulation (Hypoxia-Induced): A Pilot Study Investigating the Impact of Skin Pigmentation in Pulse Oximetry -- The Intramuscular Circulation is Affected by Neck and Shoulder Pain -- Intramuscular circulation of the lumbar multifidus in different trunk positions on standing -- Numerical Optimization of a NIRS Device for Monitoring Tissue Oxygen Saturation -- Upper trapezius muscle tonicity, assessed by palpation, relates to change in tissue oxygenation and structure as measured by Time-Domain Near Infrared Spectroscopy -- Perceived exertion correlates with multiple physiological parameters during cardiopulmonary exercise testing -- Systemic and Quadriceps Muscle O2 Dynamics in Subjects without Attenuation Point of Deoxygenated Hemoglobin Concentration during Ramp Cycling Exercise -- Jaw-Clenching Intensity Effects on Masseter Oxygen Dynamics and Fatigue: A NIRS Oximetry Study. .
    Abstract: This book contains most of the scientific contributions during the 48th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), which was held electronically in July 2021. It includes multidisciplinary contributions from scientists (physicists, biologists and chemists), engineers, clinicians and mathematicians and covers covers all aspects of oxygen transport from air to the cells, organs and organisms; instrumentation and methods to sense oxygen and clinical evidence.
    Type of Medium: Online Resource
    Pages: XXVI, 446 p. 163 illus., 100 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031141904
    Series Statement: Advances in Experimental Medicine and Biology, 1395
    DDC: 571.6
    Language: English
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    Keywords: Bioinformatics. ; Information visualization. ; Arts. ; Computational and Systems Biology. ; Data and Information Visualization. ; Fine Art.
    Description / Table of Contents: The Deadly Beauty of Cancer -- Cellular Connections -- Annealing Party -- Cells on the Ferris Wheel -- The Magic Pants that Always Fit -- Racing Triangles -- Rising Dragons -- Henri in Wonderland -- Peak of the Iceberg -- Guiding Spiral -- The Hidden Beauty of Roots -- The Beauty of a Beast -- The Ghost -- Lymph Node Landscapes -- Breezing Drops -- Labyrinths: Exotic Patterns of Cortical Activity -- Mammalian Lipidomic Network -- One Step at a Time -- How a Tumor Gets its Spots -- Patchwork Patterns -- Cancer Warfare -- Collective Decision Making -- Cell Simulation in Blossom -- Semblance of Heterogeneity -- Can we Crack Cancer? -- Dance with Predators and Prey -- Knitting Proteins -- Nothing Stands Still in the Streams of Life -- Restless Mind Wandering -- Morphological Echoes -- Cancer as a Killer Tsunami -- Cells Are Watching You -- Roots or Flowers? Take a Guess... -- Spectral Forms and Cosmic Storms -- Antigenic Explosion -- Crop Circles of Cancer -- Scalp -- Coupled Invasion -- Lost in the Cells -- Becoming Important -- Community Matters -- Acidic Dance -- Flocking, Swirling and Spinning Stars in a Cell -- A Mosaic of Cancer and Liver Tissue -- Cell Firework -- Pulled in Line -- Convergence -- Arctic Breeze -- Extracellular Galaxies -- Oriental Landscape Painting by Predator Species -- Life is Lived on the Edge -- Cellular Swarms in Cellular Automata -- Bumps, Ridges, and no Flows in Vein -- Growing Orbs / Mingled Metabolism -- Out of the Comfort Zone -- Green Protein Interaction Wheel -- Vincent van Gogh’s Autocatalysis -- Clonal Inferno -- What Lies Beneath (the Heartbeat) -- Tree of Life -- Tower of Life -- Clone Wars - The Immune System Awakens -- Modelled Cell -- CD196- -- Tumor Composition Depends on the Viewing Angle -- Poincaré’s Homoclinic Horror -- E/A/S (Evolving Asteroid Starships) -- Interacting Spider Webs -- Heart Cells are aMAZEing -- Actin Spring -- Dynamical Diggers.
    Abstract: This beautifully crafted book collects images, which were created during the process of research in all fields of theoretical biology. Data analysis, numerical treatment of a model, or simulation results yield stunning images, which represent pieces of art just by themselves. The approach of the book is to present for each piece of visualization a lucid synopsis of the scientific background as well as an outline of the artistic vision. .
    Type of Medium: Online Resource
    Pages: X, 152 p. 72 illus., 66 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030334710
    DDC: 570.285
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Molecular biology. ; Linguistics. ; Bioinformatics. ; Evolution (Biology). ; Knowledge, Theory of. ; Philosophy of nature. ; Molecular Biology. ; Linguistics. ; Bioinformatics. ; Evolutionary Biology. ; Epistemology. ; Philosophy of Nature.
    Description / Table of Contents: Language: Gateway to the World -- Truth: The Regulative Principle of Cognition -- Methods: Ways of Gaining Knowledge -- Unity: The Deep Structure of Science -- Limits: Insights into the Reach of Science -- Perspectives: Designing Living Matter -- Epilogue: Nature’s Semantics -- Author Index -- Subject Index.
    Abstract: This book, by an eminent scientist and philosopher, provides strong evidence for the claim that language is a general principle of Nature, rooted exclusively in physical and chemical laws. The author’s radical idea inevitably leads us to view the essence, origin and evolution of life in a completely new light. It shifts the coordinates of our scientific world-view in favor of an overarching concept of language that is able to bridge the gap between matter and mind. At the same time, it removes a blind spot in the Darwinian concept of evolution. To justify this far-reaching idea, the book takes a long and deep look at our scientific and philosophical thinking, at language as such, at science’s claim to truth, and at its methods, unity, limits and perspectives. These are the cornerstones structuring the book into six thematically self-contained chapters, rounded off by an epilogue that introduces the new topic of Nature’s semantics. The range of issues covered is a testimony to how progress in the life sciences is transforming the whole edifice of science, from physics to biology and beyond. The book is aimed at a broad academic and general readership; it requires no mathematical expertise.
    Type of Medium: Online Resource
    Pages: XIX, 511 p. 110 illus., 106 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030803193
    Series Statement: The Frontiers Collection,
    DDC: 572
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Bioinformatics. ; Biotechnology. ; Computational and Systems Biology.
    Description / Table of Contents: Web-based 3D visualisation of biological and medical data -- Ultrasound-Guided Regional Anaesthesia: Visualising Nerve and Needle -- Scanning conditions in functional connectivity magnetic resonance imaging: how to standardise resting-state for optimal data acquisition and visualisation? -- Interactive VR Stroke Rehabilitation System Design -- Systematic review of Augmented and Virtual Reality in anatomical education -- Interdimensional travel: Visualisation of 3D-2D transitions in anatomy learning -- Anatomy Visualizations Using Stereopsis: Assessment and Implication of Stereoscopic Virtual Models in Anatomical Education -- Storyboarding in Medical Animation -- The hidden curriculum of imaging and utilisation of unregulated social media resources within clinical education -- Online distance learning in biomedical sciences: Community, belonging and presence. .
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. The first eight chapters examine a variety of tools, techniques, methodologies and technologies which can be utilised to visualise and understand biological and medical data. This includes web-based 3D visualisation, ultrasound, virtual and augmented reality as well as functional connectivity magnetic resonance imaging, storyboarding and a variety of stereoscopic and 2D-3D transitions in learning. The final two chapters examine the pedagogy behind digital techniques and tools from social media to online distance learning techniques.
    Type of Medium: Online Resource
    Pages: XV, 181 p. 69 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030376390
    Series Statement: Advances in Experimental Medicine and Biology, 1235
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Enzymology. ; Proteins. ; Bioinformatics. ; Microbial genetics. ; Biotechnology. ; Enzymology. ; Proteins. ; Bioinformatics. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. Introduction to Glycoside Hydrolases: Classification, identification and Occurrence -- Chapter 2. Glycosyl Hydrolases – Biochemistry and Applications -- Chapter 3. Lignocellulolytic and Chitinolytic Glycoside Hydrolases: Structure, Catalytic -- Chapter 4. Role of glycosyl hydrolases in breakdown of lignocellulosic waste and its industrial applications -- Chapter 5. Marine glycosyl hydrolases as tool for industrial application -- Chapter 6. Glycosyl Hydrolases and Biofuel -- Chapter 7. Role of Glycoside hydrolases in pulp and paper industries -- Chapter 8. Application of glycosyl hydrolases in food industry -- Chapter 9. The effects of xylanase synergistic interactions during lignocellulose degradation and their significance for industry -- Chapter 10. Role of metagenomics in discovery of industrially important cellulase.
    Abstract: This book gathers selected studies on the industrial applications of glycoside hydrolases (GHs), presenting an updated classification of these enzymes, and discussing their structure, mechanisms, and various approaches to improve their catalytic efficiency. Further, it explains the various industrial applications of glycoside hydrolases in food, effluent treatment, biofuel production, and the paper and pulp industries. Lastly, the book provides a comparative analysis of glycosyide hydrolases and discusses the role of metagenomics in the discovery of industrially important enzymes. As such it is a thought-provoking, instructive and informative resource for biochemists, enzymologists, molecular biologists and bioprocess technologists. .
    Type of Medium: Online Resource
    Pages: XXI, 259 p. 35 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811547676
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Internal medicine. ; Bioinformatics. ; Biomedical Research. ; Internal Medicine. ; Bioinformatics.
    Description / Table of Contents: Part One: Basic Concepts in Precision Oncology -- Chapter 1. Design and Implementation of a precision oncology workflow -- Chapter 2. An overview of cancer genome sequencing -- Chapter 3. Software infrastructures for precision medicine workflows -- Part Two: Current Computational Methods and Tools in Precision Oncology -- Chapter 4. Somatic and germline variant calling from next-generation sequencing data -- Chapter 5. Identification of copy number alterations from next-generation sequencing data -- Chapter 6. Genome-wide discovery of large-scale structural variants from next-generation sequencing data -- Chapter 7. Assessment of microsatellite instability from next-generation sequencing data -- Chapter 8. Computational approaches for the investigation of intra-tumor heterogeneity and clonal evolution from bulk sequencing data -- Chapter 9. Analysis of the transcriptome for precision oncology applications -- Chapter 10. Computational methods for drug repurposing -- Chapter 11. Pathway for analysis for precision oncology applications -- Chapter 12. Identification of fusion transcripts from RNA-seq -- Chapter 13. Computational resources for the interpretation of variations in cancer -- Chapter 14. Analysis of electronic health records for precision oncology -- Chapter 15. Network approaches for precision oncology -- Chapter 16. Experimental validation of genomic alterations -- Part Three: Advanced Concepts - The Future of Precision Oncology -- Chapter 17. Molecular profiling of liquid biopsies for precision oncology -- Chapter 18. Artificial intelligence for precision oncology -- Chapter 19. Single-cell technologies in precision oncology -- Chapter 20. Computational approaches for precision immuno-oncology -- Chapter 21. Multi-pmics profiling of the tumor microenvironment -- Chapter 22. Epigenetic and precision oncology -- Chapter 23. Next generation knowledge bases to support precision oncology. .
    Abstract: Precision medicine holds great promise for the treatment of cancer and represents a unique opportunity for accelerated development and application of novel and repurposed therapeutic approaches. Current studies and clinical trials demonstrate the benefits of genomic profiling for patients whose cancer is driven by specific, targetable alterations. However, precision oncologists continue to be challenged by the widespread heterogeneity of cancer genomes and drug responses in designing personalized treatments. Chapters provide a comprehensive overview of the computational approaches, methods, and tools that enable precision oncology, as well as related biological concepts. Covered topics include genome sequencing, the architecture of a precision oncology workflow, and introduces cutting-edge research topics in the field of precision oncology. This book is intended for computational biologists, bioinformaticians, biostatisticians and computational pathologists working in precision oncology and related fields, including cancer genomics, systems biology, and immuno-oncology.
    Type of Medium: Online Resource
    Pages: XIV, 336 p. 36 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030918361
    Series Statement: Advances in Experimental Medicine and Biology, 1361
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Biological transport. ; Cell membranes. ; Analytical chemistry. ; Human physiology. ; Bioinformatics. ; Membrane Trafficking. ; Analytical Chemistry. ; Human Physiology.
    Description / Table of Contents: Chapter 1: The extracellular matrix goes - omics: resources and tools -- Chapter 2:The matrisome of model organisms: from in-silico prediction to big-data annotation -- Chapter 3: Detecting changes to the extracellular matrix in liver diseases -- Chapter 4: Characterization of Proteoglycanomes by Mass Spectrometry -- Chapter 5: Historical overview of integrated GAG-omics and proteomics -- Chapter 6: Extracellular matrix networks: from connections to functions -- Chapter 7: Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome -- Chapter 8: Proteomic and degradomic analysis of body fluids: applications, challenges and considerations -- Chapter 9: Regulation of Cell-Matrix Adhesion Networks: Insights from Proteomics -- Chapter 10: Integrative models for TGF- signaling and extracellular matrix.
    Abstract: This book covers different omics aspects related to the extracellular matrix (ECM), namely specific omics resources focused on the extracellular matrix (e.g., databases, repositories and atlases), quantitative proteomics applied to specific extracellular matrices (e.g. basement membranes), biological processes such as ECM degradation (degradomics), cell-matrix interactions (adhesomes), signaling pathways, biomarker discovery and diseases, and interactomics (extracellular matrix interaction networks including not only protein-protein but also protein-glycosaminoglycan interactions). The volume also includes recent advances in glycomics and glycobioinformatics applied to proteoglycans and glycosaminoglycans, which are key biological players. The use of omics data to build dynamic models of ECM-regulated biological pathways is addressed, together with the requirement to standardize omic data, which is a prerequisite for the FAIR (Findability, Accessibility, Interoperability, and Reusability) guiding principles for scientific data management. This book will be of great interest to a broad readership from beginners to advanced researchers, who are interested in extracellular matrix omics and will inspire future research topics. .
    Type of Medium: Online Resource
    Pages: VIII, 225 p. 22 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030583309
    Series Statement: Biology of Extracellular Matrix, 7
    DDC: 570.285
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Immunology. ; Bioinformatics. ; Immunology. ; Bioinformatics.
    Description / Table of Contents: Cytokine receptor signaling and CD4/CD8 lineage choice during T cell development in the thymus -- An agent-based model of T helper cell fate decisions in the thymus -- Modelling naive T cell homeostasis -- Mechanistic models of CD4 T cell homeostasis and reconstitution in health and disease -- Section 1MODELING THE DYNAMICS OF CD4+ T CELLS IN HIV- 1 INFECTION -- Modelling the response to Interleukin-7 therapy in HIV-infected patients -- Modeling immunopathology during persistent viral infections -- Delay in differentiation may suggest division of labour in models for CD8+ T cell differentiation -- Inferring differentiation order in adaptive immune responses from population level data -- Experimental and mathematical approaches to quantify recirculation kinetics of lymphocytes -- The public face and private lives of T cell receptor repertoires -- Population dynamics of immune repertoires -- Mathematical Modelling of T cell activation -- Agent-based model of heterogeneous T cell activation in vitro -- CTLA-4 mediated ligand trans-endocytosis: a stochastic model -- Automated gating and dimension reduction of high-dimensional cytometry data -- Index.
    Abstract: The purpose of this book is to present current mathematical and computational models that are used to describe and characterise the immunology of T cells. The reader will be exposed to a variety of tools/methods that go hand-in-hand with the T cell-mediated immunological process that is being modelled. We aim in the proposed book to emphasise the role that mathematical (or computational) modelling has already played in Immunology. Each chapter will provide an example of the contribution of mathematics to T cell immunology under one of the following four headings: i) Generation of hypotheses, ii) Quantification of immunological processes, iii) Definition of observables to measure given an experimental objective, iv) reconciling disparate (or even conflicting) experimental results. .
    Type of Medium: Online Resource
    Pages: X, 298 p. 74 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030572044
    DDC: 571.96
    Language: English
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    Keywords: Bioinformatics. ; Life sciences. ; Bioinformatics. ; Life Sciences. ; Bioinformatics.
    Description / Table of Contents: The new omics era into systems approaches: what is the importance of separation techniques? -- Biological Applications for LC-MS-Based Proteomics -- The role of chromatographic and electromigration techniques in Foodomics -- CE-MS for proteomics and intact protein analysis -- Peptidomics and Capillary Electrophoresis -- Discovery of native protein complexes by liquid chromatography followed by quantitative mass spectrometry -- Capillary electrophoresis based N-Glycosylation analysis in the biomedical and biopharmaceutical fields -- Practical considerations in method development for gas chromatography-based metabolomic profiling -- Capillary electrophoresis-mass spectrometry for metabolomics: possibilities and perspectives -- Liquid Chromatography – Mass Spectrometry for Clinical Metabolomics: An Overview -- Analytical platforms for mass spectrometry-based metabolomics of polar and ionizable metabolites -- Metabolomic data treatment: basic directions of the full process -- Index.
    Abstract: This book covers liquid chromatography, gas chromatography and capillary electrophoresis, the three main separation techniques lately available, applied to key omic sciences, such as genomics, proteomics, metabolomics and foodomics. The fundamentals of each technique are not covered herein. Instead, the recent advances in such techniques are presented focusing on the application to omics analyses and unique aspects in each case. This volume intends to offer wide ranging options available to researchers on omics sciences, and how to integrate them in order to achieve the comprehension of a biological system as a whole. Omic sciences have been of ultimate importance to comprehend the complex biochemical reactions and related events that occurs upon a biological system. The classical central dogma of molecular biology, which states that genetic information flows unidirectionally from DNA to RNA and then to proteins, has been gradually replaced by the systems biology approach. This book presents a multidisciplinary approach that explains the biological system as a whole, where the entire organism is influenced by a variety of internal events as well as by the environment, showing that each level of the biological information flux may influence the previous or the subsequent one. .
    Type of Medium: Online Resource
    Pages: XII, 273 p. 74 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030772529
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1336
    DDC: 570.285
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medical genetics. ; Neurosciences. ; Bioinformatics. ; Medical Genetics. ; Neuroscience. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Stratification of patients with Chronic Obstructive Pulmonary Disease using Volatile Organic Compounds -- 2-Evidence-based Leadership: A Study of its Application to General Hospital of the Public Health System through the Implementation Leadership Scale -- 3-Greek nurses’ perception of hospital ethical climate. A cross-sectional study -- 4-Investigating the main causes of conflicts and the managements strategies are used by healthcare professionals. The case of general hospital of Arta -- 5-Incidence of deep vein thrombosis and its effect on health related quality of life among nurses of Greek public hospital. A multicenter study -- 6-Factors affecting anxiety and depression in caregivers of hemodialysis patients -- 7-Hand grip strength in patients on hemodialysis: An observational study -- 8-The effect of spirituality on illness perceptions in patients undergoing hemodialysis -- 9-Validation of the STOP-Bang Questionnaire in Greek patients suffering from obstructive sleep apnea -- 10-The role of Pythagorean Self-Awareness Intervention in obstructive sleep apnea. A randomized controlled trial -- 11-Tissue characterization in Cardiology. Moving beyond function -- 12-Psychiatric care in acute care units with locked doors: Nursing care providers’ perceptions and experiences -- 13-Researching nursing students’ attitudes towards mental health practice: cultural adaptation and validation of the Greek version of the Acceptability of Locking the Door Questionnaire in acute psychiatric care -- 14-Compliance of bronchial asthma patients' with the Mediterranean diet -- 15-Nurses’ experiences of psychiatric care in acute care units with an open door policy -- 16-Validation of the Greek Version of Hedonic, Eudaimonic and Extrinsic Motives for Activities (HEEMA) Instrument -- 17-Event-Related Rumination Inventory: A Validation Process in the Greek Language -- 18-The job rotation of nursing staff and its effects on nurse`s satisfaction and occupational engagement -- 19-The burden on carers with multiple sclerosis -- 20-Attitudes of the general population regarding patient information for a chronic and life-threatening disease. A cross-sectional study -- 21-Assessment of healthcare professionals’ knowledge and awareness on aspects related to ionizing radiation examinations in Athens, Greece -- 22-Medication errors and their correlation with nurse's satisfaction. The case of the hospitals of Lasithi, Crete -- 23-Health-Related Quality of Life and Living Costs of HIV-Infected Patients -- 24-Evaluation of anxiety and depression in women undergoing mastectomy in Greece -- 25-The effect of emotional intelligence on caring behaviors among psychiatric nurses in Greece -- 26-Investigating nursing leadership in intensive care units of hospitals of Northern Greece and its relationship to the working environment -- 27-Health-Related Quality of Life and Rehabilitation Costs of Patients with Amputated Limb -- 28-Anxiety and depression in hemodialysis: Sex differences -- 29-Patient knowledge, adherence to the therapeutic regimen, and quality of life in hemodialysis -- 30-The burden of caregivers of patients after hip replacement and its impact on the cost of living of the family -- 31-The effects of exercise in patients with Sarcopenia -- 32-Fluid dynamics derived parameters in coronary vessels -- 33-Level of knowledge about COPD among patients and caregivers -- 34-Increased body mass index (BMI) and sunscreen use are associated with inadequate vitamin D status in Greek adults in winter -- 35-The effect of whole-body cryostimulation in healthy adults -- 36-Exhaled Nitric Oxide (FeNO) in patients hospitalized for an exacerbation of bronchiectasis and/or COPD -- 37-Formulation and Evaluation of Dermatological product containing Niacinamide -- 38-Exhaled breath condensate and dyspnea in COPD -- 39-The Effects of Pythagorean Self-Awareness Intervention on Irritable Bowel Syndrome Patients: A Non-Randomized Controlled Trial -- 40-Adults’ stress response to unexpected oral and arithmetic tasks in supine position -- 41-Triangles and family engagement in drug and alcohol addiction treatment -- 42-Use of fortified bread for addressing vitamin D deficiency. .
    Abstract: The 5th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Molecular Biology, Chemical Biology, and Cellular Biology.
    Type of Medium: Online Resource
    Pages: XVIII, 319 p. 137 illus., 132 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031319785
    Series Statement: Advances in Experimental Medicine and Biology, 1423
    DDC: 616.042
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biomedical engineering. ; Bioinformatics. ; Epidemiology. ; Mathematical models. ; Biomedical Engineering and Bioengineering. ; Computational and Systems Biology. ; Epidemiology. ; Mathematical Modeling and Industrial Mathematics.
    Description / Table of Contents: table of contents -- introduction -- infectious diseases -- a brief history of infectious diseases -- II. mathematical epidemiology -- introduction to compartment modeling -- compartment modeling of epidemiology -- concepts of endemic disease modeling -- data-driven modeling in epidemiology. - compartment modeling of COVID19 -- early outbreak dynamics of COVID-19 -- asymptomatic transmission of COVID-19 -- inferring outbreak dynamics of COVID-19 -- modeling outbreak control -- managing infectious diseases -- change-point modeling of COVID-19 -- dynamic compartment modeling of COVID-19 -- network modeling of epidemiology -- network modeling of epidemic processes -- network modeling of COVID-19 -- dynamic network modeling of COVID-19 -- informing political decision making through modeling -- exit strategies from lockdown -- vaccination strategies -- the second wave -- lessons learned.
    Abstract: This innovative textbook brings together modern concepts in mathematical epidemiology, computational modeling, physics-based simulation, data science, and machine learning to understand one of the most significant problems of our current time, the outbreak dynamics and outbreak control of COVID-19. It teaches the relevant tools to model and simulate nonlinear dynamic systems in view of a global pandemic that is acutely relevant to human health. If you are a student, educator, basic scientist, or medical researcher in the natural or social sciences, or someone passionate about big data and human health: This book is for you! It serves as a textbook for undergraduates and graduate students, and a monograph for researchers and scientists. It can be used in the mathematical life sciences suitable for courses in applied mathematics, biomedical engineering, biostatistics, computer science, data science, epidemiology, health sciences, machine learning, mathematical biology, numerical methods, and probabilistic programming. This book is a personal reflection on the role of data-driven modeling during the COVID-19 pandemic, motivated by the curiosity to understand it.
    Type of Medium: Online Resource
    Pages: XVI, 312 p. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030828905
    DDC: 610.28
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Biophysics. ; Biomathematics. ; Biotechnology. ; Biomedical engineering. ; Bioinformatics. ; Computational and Systems Biology. ; Biophysics. ; Mathematical and Computational Biology. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: 1-Digging for Significant Genes in Microarray Expression Data Based on Systematic Sampling and Hierarchal Clustering Algorithm -- 2-A DSS for predicting Lymphoma in primary Sjogren’s Syndrome patients -- 3-Decision Support System for Breast Cancer Detection Using Biomarker Indicators -- 4-Hepatocellular Carcinoma Detection Using Machine Learning Techniques -- 5-Web-based Decision Support System for Coronary Heart Disease Diagnosis -- 6-A Decision Support System for the Prediction of Drug Predisposition through Personality Traits -- 7-Development of a diagnostic tool for balance disorders based on machine learning techniques -- 8-Systems Approaches in the Common Metabolomics in Acute Lymphoblastic Leukemia and Rhabdomyosarcoma Cells: A Computational Approach -- 9-Bioinformatics Analyses of Spatial Peripheral Circadian Clock-Mediated Gene Expression of lucocorticoid Receptor-related Genes -- 10-Machine Learning for Autistic Spectrum Disorder Risk Screening -- 11-Mobile Application for Monitoring and Preventing Cognitive Decline through Lifestyle Intervention -- 12-Virtual Reality Zoo Therapy for Alzheimer’s Disease Using Real-time Gesture Recognition -- 13-Validation of the Greek Version of Social Media Disorder Scale -- 14-Adiponectin and its Effects on Acute Leukemia Cells: An Experimental and Bioinformatics Approach -- 15-Nature and quantum inspired procedures - a short literature review -- 16-Handling the cellular complex systems in Alzheimer’s disease through a graph mining approach -- 17-Debunking the neuromyth of learning style -- 18-Expert characteristics: implications for expert systems -- 19-Improving the Run-Time of Space E cient n-gram Data Structures using Apache Spark -- 20-Development of a protein biochip platform for Parkinson’s disease -- 21-The Cultural adaptation of the iSupportDementia in Greece -- 22-The use of data collection and big data analysis in Neurodegenerative disease prevention -- 23-Fractal Dynamics in the RR Interval of Craniopharyngioma and Adrenal Tumor in Adolescence -- 24-Bioinformatics approaches for Parkinson’s disease in clinical practice: Data- driven biomarkers and pharmacological treatment -- 25-Emerging Machine Learning techniques for modelling cellular complex systems in Alzheimer’s disease -- 26-Cognitive Enhancement Through Mathematical Problem Solving -- 27-Cognitive tasks of an information system for memory training and cognitive enhancement using mobile devices -- 28-An application for exploring visual perception. A pilot neuroeducational study -- 29-Genes Classification Based on Multi Class SVMs with Systematic Sampling and Hierarchical Clustering (SSHC) Algorithm -- 30-Multinetwork motor learning as a model for dance in neurorehabilitation -- 31-Controlling the chimera form in the Leaky Integrate-and-Fire model -- 32-Qualitative differences between the Semi-separable and the “Almansi type” Stokes stream function expansions in the study of biological fluids -- 33-A multiscale mathematical model for tumor growth, incorporating the GLUT1 expression.
    Abstract: The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. Computational methodologies for implementation on the discovery of biomarkers for neurodegenerative diseases are extensively discussed. This volume focuses on the sessions from the conference regarding computational biology and bioinformatics.
    Type of Medium: Online Resource
    Pages: XV, 288 p. 105 illus., 92 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030787752
    Series Statement: Advances in Experimental Medicine and Biology, 1338
    DDC: 570.285
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Cytology. ; Medicine Research. ; Biology Research. ; Computational and Systems Biology. ; Cell Biology. ; Biomedical Research. ; Bioinformatics.
    Description / Table of Contents: Chapter 1: The Structure And Function Of Living Organisms -- Chapter 2: Energy In Biology – Demand And Use -- Chapter 3: Information – Its Role And Meaning In Organism -- Chapter 4: Regulation In Biological Systems -- Chapter 5: Interrelationship In Organized Biological Systems. .
    Abstract: This open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology. The fully updated 2nd edition also contains information that has only become available as a result of the increase in knowledge in recent years. This includes information on tumorigenesis, where significant progress has been made due to the explosive development of genetic knowledge as well as bioengineering with a highly effective technique adopted from the solutions of the bacterial world, such as CRISPR/CAS. This richly illustrated book is essential for postgraduate students and scientists of the following disciplines: biology, biotechnology, medicine, bioinformatics, robotics and automation, biocybernetics, and biomedical engineering. It is also an exciting read for anyone interested in biology.
    Type of Medium: Online Resource
    Pages: XVII, 257 p. 1 illus. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031315572
    DDC: 570.285
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Bioinformatics. ; Sports sciences. ; Medical informatics. ; Biomedical Research. ; Bioinformatics. ; Sport Science. ; Health Informatics.
    Description / Table of Contents: Chapter 1. Ontologies and Knowledge Graphs for Exercise Medicine -- Chapter 2. Participatory exercise medicine and personalized healthcare -- Chapter 3. Integration of genetic and phenotyping data for sports medicine -- Chapter 4. Microbiota, sports and exercise medicine -- Chapter 5. Human immune system and exercise medicine: current process and future directions -- Chapter 6. Circadian Rhythm and Personalized Exercise -- Chapter 7. Data-driven Exercise Medicine for Cardiovascular Disease -- Chapter 8. Physical Activities and Prevention of Neurodegenerative Diseases -- Chapter 9. Exercise guidelines for cancer patients -- Chapter 10. Diabetes as a metabolic disease and translational exercise medicine informatics.
    Abstract: The book provides readers the informatics and data-driven models for the discovery of personalized excise prescriptions applied to different cases. Overdiagnosis or over-treatment often happened since the complex interaction among the lifestyle, genetic, and environmental factors. Sports and exercise are reported efficient to prevent or reduce the risk of diseases, but the interactions between sports/exercise and disease are personalized and complex. Translational informatics is a powerful paradigm and it promotes the transfer of big data, knowledge and models to the precision application of sports to prevent diseases. Sports and exercise may have different effects on diverse diseases including cancers, neurodegenerative disease, and cardiovascular diseases, etc. This book covers many modern informatics models such as ontologies, knowledge graphs, blockchain, participatory medicine, semantic artificial intelligence, big data modeling, and so on. It also describes the challenges for the sports and exercise medical data sharing and standardization, the privacy protection of data as well as the integration of data from genomic level to physiological phenotype level. This book will be helpful to the readers who are interesting in sports and exercise medicine, healthcare, big data modeling, artificial intelligence in medicine and healthcare. .
    Type of Medium: Online Resource
    Pages: IX, 234 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811691621
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Synthetic Biology. ; Bioinformatics. ; Drug delivery systems. ; Industrial microbiology. ; Synthetic Biology. ; Bioinformatics. ; Drug Delivery. ; Industrial Microbiology.
    Description / Table of Contents: Chapter 1. Actinomycetes: Microbiology to Systems Biology -- Chapter 2. Diversity of actinobacteria in various habitats -- Chapter 3. Traditional Screening and Genome Guided Screening of Natural Products from Actinobacteria -- Chapter 4. The relationship between actinobacteria and rice -- Chapter 5.Non-ribosomally and ribosomally synthesized bioactive peptides – NRPS and RiPPs from actinobacteria -- Chapter 6. Genome Data Mining, Chemistry and Bioactivity of Sesquiterpenes from Actinobacteria -- Chapter 7. Genome Data Mining, Chemistry and Bioactivity of Sesquiterpenes from Actinobacteria -- Chapter 8. Cloning and Heterologous expression of Natural products from Actinobacteria -- Chapter 9. Synthetic Biology and Metabolic Engineering in Actinobacteria for Natural Product Production -- Chapter 10. CRISPR ERA: CURRENT APPLICATIONS AND FUTURE PERSPECTIVES ON ACTINOBACTERIA -- Chapter 11. Uncultured Actinobacteria and Reverse engineering and Artificial Intelligence role in future -- Chapter 12. Cultivation and Diversity of Marine Actinomycetes: Molecular Approaches and Bioinformatics Tools -- Chapter 13. Antimicrobial Potential and Metabolite Profiling of Marine Actinobacteria -- Chapter 14. Pharmacology of FDA Approved Medicines from Actinobacteria.
    Abstract: This book summarizes the basics of actinobacteria, from microbiology to synthetic biology. It focuses on diversity, NRPS, sesquiterpenes, lantipeptide, bioinformatics apparatuses, cloning, CRISPR, reverse engineering, FDA supported medications, and marine actinobacteria. It also covers the latest trends in drug discovery from actinobacteria, and introduces several recently developed bioinformatics and synthetic biology tools to explore new antibiotics from actinobacteria. Many natural products such as polyketides, isoprenoids, phenazines, peptides, indolocarbarbazoles, sterols, and others have been isolated and characterized from actinobacteria. Some products are synthesized by the non-ribosomal peptide synthetases (NRPSs), polyketide synthases (PKSs), or other functional genes. Although genome sequencing has uncovered the differing qualities of these chemicals, recognizing new items and their biosynthetic pathways is still under examination. Cryptic metabolic pathways have been explored using molecular techniques or culture-dependent approaches. In recent years, researchers’ primary interest is to identify the specific conditions or agents that wake the cryptic antibiotics. Several bioinformatics and synthetic biology tools were developed to explore new antibiotics from actinobacteria. The book comprises 14 chapters with different aspects of application and utilization of actinomycetes from the microbiology; systems biology, pharmacology of natural products, bioinformatics, actinomycete and its diversity, CRISPR, artificial Intelligence, synthetic biology, metabolic engineering, expressional studies, and biosynthetic gene clusters. The book delivers useful information on actinomyces to researchers, novices in genome designing, specialists, clinicians, policymakers, and professionals.
    Type of Medium: Online Resource
    Pages: XV, 276 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811658358
    DDC: 570.724
    Language: English
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    Keywords: Neurosciences. ; Neural circuitry. ; Bioinformatics. ; Computer science. ; Neuroscience. ; Neural Circuits. ; Computational and Systems Biology. ; Computer Science.
    Description / Table of Contents: PART I. Cellular Scale -- Chapter 1. Modelling Neurons in 3D at the Nanoscale -- Chapter 2. Modelling Dendrites and Spatially-Distributed Neuronal Membrane Properties -- Chapter 3. A User's Guide to Generalized Integrate-and-Fire Models -- Chapter 4. Neuron-glia Interactions and Brain Circuits -- Chapter 5. Short-term Synaptic Plasticity: Microscopic Modelling and (some) Computational Implications -- PART II. Molecular Scale -- Chapter 6. The Mean Field Approach for Populations of Spiking Neurons -- Chapter 7. Multidimensional Dynamical Systems with Noise -- Chapter 8. Computing Extracellular Electric Potentials from Neuronal Simulations -- Chapter 9. Bringing Anatomical Information into Neuronal Network Models -- PART III. Network Scale -- Chapter 10. Computational Concepts for Reconstructing and Simulating Brain Tissue -- Chapter 11. Reconstruction of the Hippocampus -- Chapter 12. Challenges for Place and Grid Cell Models -- Chapter 13. Whole-Brain Modelling: Past, Present, and Future.
    Abstract: This volume offers an up-to-date overview of essential concepts and modern approaches to computational modelling, including the use of experimental techniques related to or directly inspired by them. The book introduces, at increasing levels of complexity and with the non-specialist in mind, state-of-the-art topics ranging from single-cell and molecular descriptions to circuits and networks. Four major themes are covered, including subcellular modelling of ion channels and signalling pathways at the molecular level, single-cell modelling at different levels of spatial complexity, network modelling from local microcircuits to large-scale simulations of entire brain areas and practical examples. Each chapter presents a systematic overview of a specific topic and provides the reader with the fundamental tools needed to understand the computational modelling of neural dynamics. This book is aimed at experimenters and graduate students with little or no prior knowledge of modelling who are interested in learning about computational models from the single molecule to the inter-areal communication of brain structures. The book will appeal to computational neuroscientists, engineers, physicists and mathematicians interested in contributing to the field of neuroscience. Chapters 6, 10 and 11 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. .
    Type of Medium: Online Resource
    Pages: XII, 359 p. 115 illus., 94 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030894399
    Series Statement: Cellular Neuroscience, Neural Circuits and Systems Neuroscience, 1359
    DDC: 612.8
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Plant genetics. ; Bioinformatics. ; Life sciences. ; Plant Genetics. ; Bioinformatics. ; Life Sciences.
    Description / Table of Contents: 1. Introduction to plant omics and systems biology -- 2. Modern approaches for transcriptome analyses in plants -- 3. Plant proteomics and systems biology -- 4. Subcellular proteomics as a unified approach of experimental localizations and computed prediction data for Arabidopsis and crop plants -- 5. The contribution of metabolomics to systems biology: current applications bridging genotype and phenotype in plant science -- 6. Interactomes: Experimental and in silico approaches -- 7. Probabilistic graphical models applied to biological networks -- 8. Cataloging posttranslational modifications in plant histones -- 9. Current challenges in plant systems biology -- 10. Contribution of omics and systems biology to plant biotechnology.
    Abstract: In the post-genomic era, several plant species have been sequenced and massive genomic information is now available which contributed to expand the development of novel technical strategies for the study of additional levels of biological information of plant species. This book focuses on the “omics” approaches together with systems analysis of several different plant species, which have revealed very interesting variations on the cellular responses at the protein, transcript and metabolite levels in response to changes environmental conditions. The volume covers recent technological advances in the area of “omics” and synthesizes recent findings of the field of plant “omics” and systems biology together along with techniques that can be applied for such studies.
    Type of Medium: Online Resource
    Pages: XXIV, 201 p. 18 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030803520
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1346
    DDC: 581.35
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Biotechnology. ; Mathematics. ; Civil engineering. ; Biomaterials. ; Computational and Systems Biology. ; Biotechnology. ; Applications of Mathematics. ; Civil Engineering. ; Biomaterials.
    Description / Table of Contents: Chapter1. Adhesion of living cells: Mechanisms of adhesion and contact models (F.M. Borodich, B.A. Galanov, L.M. Keer, and M.M. Suarez-Alvarez) -- Chapter2. Contact problem in indentation measurements of soft, biological and bioinspired materials. Indentation of soft materials, biological cells (I. Sokolov ) -- Chapter 3. Mechanical properties of the cell surface layer measured by contact atomic force microscopy (M. N. Starodubtseva ) -- Chapter4. Capillary adhesion effect in contact interaction of soft materials (I.G. Goryacheva, Yu.Yu. Makhovskaya) -- Chapter 5. Influence of a soft elastic layer on adhesion of rough surfaces (Q. Li, I.A. Lyashenko, R. Pohrt, V.L. Popov ) -- Chapter6. Asymptotic modeling scheme for analysis of bio-inspired fibrillar adhesive interfaces — A short review (I. Argatov ) -- Chapter 7. Spreading of red caviar cells: The knife-cell and the cell-cell adhesive interactions (F.M. Borodich and S.N. Gorb ) -- Chapter 8. Mechanical characterisation of polymeric materials using nanoindentation (H. Gonabadi, A. Yadav and S. Bull ) -- Chapter 9. Indentation tests of biological materials: Theoretical aspects (X. Jin, P. Li and F.M. Borodich ) -- Chapter 10. Contact of sliders with viscoelastic solids (E. Torskaya, F. Stepanov ) -- Chapter 11. Characterisation of an AFM tip bluntness using indentation of soft materials (S. Baqain, F.M. Borodich, and E. Brousseau ) -- Chapter 12.The JKR formalism in applications to problems of adhesive contact (F.M. Borodich ).
    Abstract: This book contains contributions from leading researchers in biomechanics, nanomechanics, tribology, contact mechanics, materials science and applications on various experimental techniques including atomic force microscopy (AFM) for studying soft, biomimetic and biological materials and objects. Biologists, physicists, researchers applying methods of contact mechanics and researchers testing materials using indentation techniques along with many other applied scientists will find this book a useful addition to their libraries. Moreover, several reviews in this book are written as introductions to several important and rather sophisticated research areas such as depth-sensing indentation, studying of biological cells by AFM probes, mechanics of adhesive contact and contact between viscoelastic (hereditary elastic) solids. The book containing new theoretical models, results of experimental studies and numerical simulations, along with reviews of above mentioned areas of contact mechanics in application to biological systems, would be beneficial for researchers in many areas of biology, medicine, engineering, mechanics and biomimetics. .
    Type of Medium: Online Resource
    Pages: XIV, 287 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030851750
    Series Statement: Biologically-Inspired Systems, 15
    DDC: 570.285
    Language: English
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    Keywords: Botany. ; Microbiology. ; Agriculture. ; Bioinformatics. ; Microbial ecology. ; Physical geography. ; Plant Science. ; Microbiology. ; Agriculture. ; Bioinformatics. ; Microbial Ecology. ; Earth System Sciences.
    Abstract: The third volume of the series ‘Bacilli and Agrobiotechnology’ is comprised of 25 chapters that bring a unique perspective to the readers about Bacillus-mediated biotic and abiotic plant stress tolerance, bioremediation and bioprospecting. These chapters are prepared by the leading scientists of global repute. The negative impacts of agrochemicals such as chemical fertilizers and pesticides on human health and environment are paramount. Bacillus and allied genera of beneficial plant-associated microbes are presenting beacon of hope to the farmers, plant scientists and stewards of environment. Several chapters of this volume focus on the induction of various signaling pathways in plants by Bacillus spp. to alleviate biotic and abiotic stresses impacted by global climate change Agricultural lands contaminated with heavy metals affect the ecological food chain starting from crop cultivation. How the toxic effects of trace metals originating from industrial effluents and agrochemicals can be remediated? This book addresses how to overcome these issues by applying elite strains of Bacillus. Bioprospecting is a systematic and organized search for conversion of bioresources to industrially important products by utilizing microbe-derived metabolites. This volume is enriched by including the bioprospecting aspects mediated by Bacillus spp. with novel insights.
    Type of Medium: Online Resource
    Pages: VII, 612 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030854652
    Series Statement: Bacilli in Climate Resilient Agriculture and Bioprospecting,
    DDC: 580
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Epigenetics. ; RNA Metabolism. ; Biochemistry. ; Bioinformatics. ; Epigenetics. ; RNA Metabolism. ; Biological Chemistry. ; Bioinformatics.
    Description / Table of Contents: Epitranscriptomic Modifications and How to Find them -- Epitranscriptomic Signature in Neural Development and Disease -- The Emerging Neuroepitranscriptome -- Epitranscriptomics and Diseases -- Epitranscriptomic Marks and Systems Involved in Gene Regulation, Development and Disease -- Experimental Approaches and Computational Workflows for Systematic Mapping and Functional Interpretation of RNA Modifications -- RNA Modifications: The Mediator Between Cellular Stresses and Biological Effects -- Computational Prediction and Experimental Validation of Specific Modified RNA Sites -- Regulation of RNA Stability Utilizing RNA Modification -- Dynamic RNA Modification Upon Extracellular Stimulus -- RNA Methylation in Cancer -- Regulation of RNA Methylation yy TET Enzymes -- RNA N6-Methyladenosine and G-Quadruplex Structures in Bacteria -- RNA N6-Methyladenosine Chemical Modification as a Therapeutic Target -- Cap-Adjacent m6Am and its Effects On mRNA -- N6-Methyladenosine in The Heart -- The m6a RNA Methylation Regulates Oncogenic Signaling Pathways Driving Cell Transformation and Carcinogenesis -- Psivar: A Database of Functional Variants Involved in Pseudouridylation (Ψ) with Implications for Disease Pathogenesis -- C-to-U RNA Editing by Mammalian APOBEC Enzymes -- The Powerful Mechanism of RNA Editing and its Therapeutic Potentials -- Noncanonical Caps in RNA -- Mass Spectrometry-Based Methods for Characterization of Hypomodifications in tRNA -- Dynamic mRNA Modifications in Plants -- The Mammalian Mitochondrial Epitranscriptome -- Epitranscriptomics Modifications of Micrornas: Classes, Detection, Impact on their Functionality and Next Frontiers -- “Look Before You Leap” when Editing the Introns, or the Secrets Behind the Intronic Post-Transcriptional Modification -- Functional Links Between the Internal N6-Methyl Adenosine Modifications in mRNAs and Human Diseases -- RNA Modifications in Neurodevelopment and Neurodegenerations -- Conventional and Advanced Techniques for Methyl-6-Adenosine Modification Mapping in Transcripts -- Mechanisms and Therapeutic Applications of RNA-Guided RNA Pseudouridylation -- Epitranscriptomic Modifications in lnRNA and miRNA in Cancer and Other Diseases -- RNA m6A and Adipogenesis.
    Abstract: This book reviews a novel and exciting field of cellular and molecular biology called epitranscriptomics, which focuses on changes in an organism’s cells resulting from the posttranscriptional modification of cellular RNA. RNA-binding proteins (RBPs) play a crucial role in these posttranscriptional modifications and also support several cellular processes necessary for maintaining RNA homeostasis. Exploring the mechanisms underlying RNA modifications and RBP function is an emerging area of biomedical research, taking the study of gene regulation a step beyond epigenetics. This book reveals that the RNA molecule is not just an information-carrying molecule with some secondary structures. Accordingly, how RNA is modified, regulated, packaged, and controlled is an important aspect. Leading experts address questions such as where the over 170 distinct posttranscriptional RNA modifications are located on the genome, what percentage of mRNAs and noncoding RNAs these modifications include, and how an RNA modification impacts a person’s biology. In closing, the book reviews the role of RNA modifications and RBPs in a variety of diseases and their pathogenesis. Addressing some of the most exciting challenges in epitranscriptomics, this book provides a valuable and engaging resource for researchers in academia and industry studying the phenomena of RNA modification.
    Type of Medium: Online Resource
    Pages: X, 632 p. 90 illus., 84 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030716127
    Series Statement: RNA Technologies, 12
    DDC: 572.865
    Language: English
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    Keywords: Pharmacology. ; Natural products. ; Nanobiotechnology. ; Bioinformatics. ; Diseases Causes and theories of causation. ; Molecular biology. ; Pharmacology. ; Natural Products. ; Nanobiotechnology. ; Bioinformatics. ; Pathogenesis. ; Molecular Biology.
    Description / Table of Contents: 1. COVID-19: An overview of virology, mutations, pathology, epidemiology, diagnosis, preventions and treatments -- 2. The recent development of therapeutic strategies against COVID-19 -- 3. Plant immunoenhancers: Promising ethnopharmacological candidates for anti-SARS-CoV-2 activity -- 4. Herbal formulations in fighting against the SARS-CoV-2 infection -- 5. Rejuvenation of traditional medicine in the 21st century against SARS-CoV-2 -- 6. Traditional herbal medicines and their active constituents in combating SARS-CoV-2 infection -- 7. Antiviral phytocompounds against animal-to-human transmittable SARS-CoV-2 -- 8. Plants-derived bioactive compounds as potential ACE-2 inhibitors against SARS-CoV-2 infection -- 9. Insights into in silico methods to explore plant bioactive substances in combating SARS-CoV-2 -- 10. Dietary plants, spices and fruits in curbing SARS-CoV-2 virulence -- 11. Therapeutic potential of selected medicinal plants for neurological disorders after the infection of COVID-19 -- 12. Glycyrrhizae Radix et Rhizoma (Gan Cao) for the management of COVID-19 -- 13. COVID-19-induced kidney disease: Ethnopharmacological intervention to ameliorate kidney damage and improve kidney function -- 14. Phytochemicals and nutraceuticals targeting SARS-CoV-2: An in silico analysis -- 15. Therapeutic and prophylactic effects of plant derivatives against SARS-CoV-2 -- 16. Therapeutic potential of essential oils against SARS-CoV-2 infection -- 17. Antiviral properties of South Indian plants against SARS-CoV-2 -- 18. Immune-boosting plants used in Turkish folk medicine and their potential against COVID-19 -- 19. A comparison study of medicinal plants used against SARS-CoV-2 and those recommended against malaria in Africa -- 20. Exploring the potential antiviral properties of Nigella sativa L. against SARS-CoV-2: Mechanisms and prospects -- .
    Abstract: This book presents a complete overview of COVID-19 and provides a series of in-depth analyses of the literature and a comprehensive discussion and perspectives on promising anti-SARS-CoV-2 agents based on the system of ethnopharmacology, which covers Chinese medicine, traditional medicines of India and Africa, Turkish folk medicine, essential oils, and some well-known medicinal plants. In this book, the current status of therapeutic strategies against COVID-19 was summarized and a perspective of potential options for the future was proposed. Based on ethnopharmacology, some well-established traditional herbal formulations and bioactive compounds with anti-virus activity were repurposed for managing COVID-19 and post-illness, including neurological disorders and kidney illness. Using drug discovery tools, promising immune enhancers were explored from phytochemicals against SARS-CoV-2. Nutraceuticals from dietary plants, spices, and fruits with anti-virus and antioxidant activities were recommended to prevent infection or severe illness caused by emerging variants. With the aid of systems pharmacology, researchers have gained insights into possible molecular mechanisms of anti-SARS-CoV-2 activity and have predicted a range of candidate compounds from medicinal plants to combat COVID-19. This book explores the current knowledge of drug discovery and ethnopharmacology for managing coronavirus diseases. The content proved the anti-SARS-CoV-2 activity from natural products and traditional herbal medicines. It contributes to the management of global public health and fits the goal of establishing “Good Health and Well-Being,” which is one of “The Sustainable Development Goals (SDGs) 2030".
    Type of Medium: Online Resource
    Pages: IX, 590 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819936649
    DDC: 615
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Natural products. ; Mass spectroscopy. ; Microbial genetics. ; Bioinformatics. ; Natural Products. ; Mass Spectrometry. ; Microbial Genetics. ; Computational and Systems Biology.
    Description / Table of Contents: Chapter 1: Microbial metabolomics – Introduction -- Chapter 2: Microbial metabolomics -- Chapter 3: Unveiling microbial chemical interactions based on metabolomics approaches -- Chapter 4: Unveiling chemical interactions between insects -- Chapter 5: Discovering new natural products using metabolomics approaches -- Chapter 6: Advances in mass spectrometry -- Chapter 7: Advances in NMR-metabolomics based approaches -- Chapter 8: Sample preparation in microbial metabolomics -- Chapter 9: Secondary Metabolite annotation using GNPS database. .
    Abstract: This book focuses on the importance of omics strategies and de-replication analysis to unveil new molecules from microbial sources with diverse chemical structures and biological functions. Chapters address metabolomics strategies, which will lead to a better understanding of the chemical interactions between microorganisms, plant-microorganisms, and virus-microorganisms. Authors also describe analytical tools used in microbial metabolomics and natural products discovery, in addition to describing a step-by-step protocol to identify and annotate metabolites using various databases and online platforms. The book presents the newest research, tools, and protocols for chemists, biochemists, bio-and chemical engineers, and biotechnologists, among others.
    Type of Medium: Online Resource
    Pages: VIII, 250 p. 47 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031417412
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1439
    DDC: 547
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Bioinformatics. ; Diseases. ; Computational and Systems Biology. ; Bioinformatics. ; Diseases.
    Description / Table of Contents: Chapter 1. Graph Theory in the Biological Networks -- Chapter 2. Biological Networks Analysis -- Chapter 3. Network Analysis based software packages, tools, and web servers to accelerate bioinformatics research -- Chapter 4. Networks Analytics of Heterogeneous Big Data -- Chapter 5. Network Medicine: Methods and Applications -- Chapter 6. Role of R in Biological Network Analysis -- Chapter 7. Machine Learning in Biological Networks.
    Abstract: This book presents methods and tools of network biology and bioinformatics for understanding the disease dynamics and identification of drug targets. The initial section of chapters introduce the theoretical aspects followed by the different applications for construction and analysis of biological networks, methods for identifying crucial nodes in networks, and network dynamics. The book covers the latest advances in the network medicine, exploring the different types of biological networks, and their applications. It further reviews the role of R language in the network-based approaches that help in understanding biological systems and identifying biological functions. Towards the end, the book explores the recent developments and applications in machine learning and its potential for advancing network biology. Finally, the book elucidates a comprehensive yet a representative description of challenges associated with the understanding of disease dynamics using network biology. Given its scope, the book is intended for researchers and advanced postgraduate students of bioinformatics, computational biology, and medical sciences.
    Type of Medium: Online Resource
    Pages: X, 125 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789819942428
    DDC: 570.285
    Language: English
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    Keywords: Paleoecology. ; Paleontology . ; Bioinformatics. ; Archaeology. ; Earth sciences. ; Paleoecology. ; Paleontology. ; Computational and Systems Biology. ; Archaeology. ; Earth Sciences.
    Description / Table of Contents: Chapter1. Introduction to Indian Late Cretaceous-Early Palaeocene Microbiota from the Deccan Intertrappean Beds of the Chhindwara District, Madhya Pradesh, India -- Chapter 2. Historical Background of Late Cretaceous-Early Palaeocene Microbiotic Assemblages from the Deccan Intertrappean Beds of the Chhindwara District, Madhya Pradesh, India -- Chapter 3. Geology and Stratigraphy of Microbiota-Bearing Deccan Intertrappean Beds of the Chhindwara District, Madhya Pradesh, India -- Chapter 4. Indian Late Cretaceous-Early Palaeocene Deccan Microbiota from Chhindwara District, Madhya Pradesh: Systematic Studies -- Chapter 5 Palaeoecological and Palaeoenvironmental Implications of the Cretaceous-Palaeogene Microbiota-Bearing Deccan Intertrappean beds of the Chhindwara District, Madhya Pradesh, India -- Chapter 6. Palaeobiogeographical Implications of Late Cretaceous-Early Palaeocene Microbiota from the Deccan Intertrappean beds of the Chhhindwara District, Madhya Pradesh, India.
    Abstract: This book describes the microbiota of the intertrappean beds in the Chhindwara District, Madhya Pradesh, India. In this work, special emphasis is placed on the microbiota from the Late Cretaceous-Early Palaeocene transition of the central Narmada River region. Recently, the intertrappean beds of the Eastern Deccan Volcanic Province (one of the subprovinces of the Deccan Volcanic Province) have received considerable attention, which resulted in the addition of some significant biotic assemblages to the existing record from the Dindori-Chhindwara area of the province. The biotic assemblages include charophytes, ostracods, foraminiferans, fishes, frogs, lizards, turtles, crocodiles, and mammals. In spite of the recent discoveries, the known fossil record of the Late Cretaceous-Early Palaeocene biota of India is not sufficient and thus does not permit us to speculate on the possible impact of environmental changes triggered by the Deccan volcanic lava flows on the contemporary biota and to precisely document their palaeoecologic, palaeoenvironmental and palaeobiogeographic implications. The recent biotic reports from the intertrappean beds exposed in the Chhindwara region of the Eastern Deccan Volcanic Province clearly indicate that these beds have a vast potential in terms of fossil content, which could reveal new and dissimilar biotic remains when compared to the Western Deccan Volcanic Province. The record of diverse accumulations of freshwater charophytes, brackish to freshwater ostracods, and planktic foraminiferal and fish assemblages from the intertrappean beds of Jhilmili and adjacent areas of Early Danian (P1a) age and lying just north of Chhindwara town and in the heart of peninsular India has intriguing implications for defining the age limits of the basaltic flows. The occurrence of non-marine taxa, for example, algae, molluscs, and vertebrates, associated with brackish water ostracods in the nearby Singpur and Mohgaon Kalan localities of the Chhindwara region, has also raised concerns about the sedimentary environments of these intertrappean beds. The new finds (presented in this book) prove useful for the better understanding of the palaeoecology and palaeoenvironment of the biota and also throw light on various paleobiogeographic models proposed for the northward drifting Indian plate. The microbiotic assemblages of the intertrappean beds of the eastern Deccan volcanic province at District Chhindwara, Madhya Pradesh are documented in this book. The microbiota of the central Narmada River region, the charophytes, ostracods, planktic foraminifera, and fishes, receive special attention in this study.
    Type of Medium: Online Resource
    Pages: XXIII, 274 p. 55 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031288555
    Series Statement: Topics in Geobiology ; 54
    DDC: 560.45
    Language: English
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    Keywords: Paleontology . ; Paleoecology. ; Bioinformatics. ; Physical geography. ; Paleontology. ; Paleoecology. ; Computational and Systems Biology. ; Earth System Sciences.
    Description / Table of Contents: Chapter 1 -- History of the NOW. Chapter 2 -- The NOW now. Chapter 3 -- The Siwaliks: A Miocene terrestrial record densely sampled at age resolution of 105 years. Chapter 4 -- Evolution of Western Asian mammal communities in the Miocene. Chapter 5 -- The fall of the Pikermian paleobiome at the crossroads of the European-Asian-African continents. Chapter 6 -- Islands in Transition: Changes in Mammalian Communities on Africa and South America. Chapter 7 -- Environmental change and body size evolution in Neogene large mammals of Europe and North America. Chapter 8 -- Body mass effects to the mammalian Niche Exploitation Profiles and to the predictions of Climate and Seasonality of Tropical Extant and Palaeo-habitats. Chapter 9 -- The mouse is dead, long live the mouse (Patterns of longevity in small mammals). Chapter 10 -- How often do mammalian species of the same genus co-occur in the fossil record and today? Chapter 11 -- Cut not shaven, the use of filters in processing data. Chapter 12 -- The effects of NOW data quality, including regional and temporal differences, on evolutionary analysis; examples from studies on large Neogene carnivore families. Chapter 13 -- Asynchroneity in the evolution of New World and Old World hypsodont Equidae. Chapter 14 -- Muskdeer on the run – Dispersal of Moschidae in the context of environmental changes. Chapter 15 -- Late Neogene Western Eurasian bovid palaeocommunities. Chapter 16 -- New giraffid determinations for the faunas of Pikermi, Samos and Maragheh. Chapter 17 -- Regional topography and climate influence the nature and timing of changes in the structure of rodent and lagomorph communities through the Cenozoic of North America. Chapter 18 -- Diet and locomotor trends in rodents during Cenozoic global cooling. Chapter 19 -- Using diachronic biogeographic patterns of mammalian dispersals between Africa and Eurasia to infer about tempo and mode of the dispersal of the genus Homo.
    Abstract: This volume presents an array of different case studies which take as primary material data sourced from the NOW (‘New and Old Worlds’) database of fossil mammals. The NOW database was one of the very first large paleobiological databases, and since 1996 it has been expanded from including mainly Neogene European land mammals to cover the entire Cenozoic at a global scale. In the last two decades the number of works that are based in the use of huge databases to explore ecological and evolutionary questions has increased exponentially, and even though the importance of big data in paleobiological research has been outlined in selected chapters of general works, no volume has appeared before this one which solely focuses on the databases as a primary source in reconstructing the past. The purpose of this book is to provide an illustrative volume showing the importance of big data in paleobiological research, and presenting a broad array of unpublished examples and case studies. The book is mainly aimed to professional palaeobiologists working with Cenozoic land mammals, but the scope of the book is broad enough to fit the interest for evolutionary biologists, paleoclimatologists and paleoecologists. The volume is divided in four parts. The first part includes two chapters on the development of large paleobiological databases, providing a first-hand account on the logic and the functioning of these databases. This is a much-needed perspective which is ignored by most researchers and users of such databases and, even if centered in the NOW database, the lessons that can be learned from this part can be extended to other examples. After this introductory part, the body of the book follows and is divided into three parts: patterns in regional faunas; large scale patterns and processes; and ecological, biogeographical and evolutionary patterns of key taxa. Each chapter is written by well-known specialists in the field, with some participation of members of the NOW advisory board. The array of selected mammal taxa ranges from carnivores, equids, ruminants and rodents to the genusHomo. The topics studied also include the diversification and radiation of major clades, large-scale paleobiogeographical patterns, the evolution of ecomorphological patterns and paleobiological problems such as evolution of body size or species longevity. In most cases the results are discussed in relation to protracted environmental or paleogeographic changes.
    Type of Medium: Online Resource
    Pages: XVII, 231 p. 67 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031174919
    Series Statement: Vertebrate Paleobiology and Paleoanthropology,
    DDC: 560
    Language: English
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    Keywords: Paleontology . ; Bioinformatics. ; Environment. ; Water. ; Hydrology. ; Ecology . ; Environmental monitoring. ; Paleontology. ; Computational and Systems Biology. ; Environmental Sciences. ; Water. ; Ecology. ; Environmental Monitoring.
    Description / Table of Contents: Foreword -- Preface -- Introduction -- Acknowledgments -- Chapter 1. State-of-the-art -- Chapter 2. Study area, material and methods -- Chapter 3. Taxonomic classification of foraminifera -- Chapter 4. Modern foraminifera -- Chapter 5. Quaternary bio- and ecostratigraphy, with elements of paleogeography of the Ponto-Caspian Corridors -- Chapter 6. Origin and taxonomy of the Pleistocene Ponto-Caspian benthic foraminifera -- Chapter 7. Benthic foraminifera as indicators of environmental change in the Black Sea in space and time -- Chapter 8. Systematic part -- Conclusions -- Index.
    Abstract: This handbook in two volumes offers a heretofore unavailable compilation of detailed information on foraminifera of the Caspian-Black Sea-Mediterranean Corridors (“CORRIDORS”), including their taxonomy, ecology, and applications in the study of Quaternary stratigraphy, paleogeographic reconstruction, and environmental stress. This subject is significant in light of the ongoing debates regarding the Flood Hypotheses because foraminifera can provide more information about many of the disputed questions. Foraminifera are highly reliable paleoenvironmental indicators, ubiquitous in marine environments, and taxonomically diverse, which gives them the potential for a wide range of biological responses to varied environmental factors. Their tests are readily preserved and can record evidence of environmental change through time, thus providing historical baseline data even in the absence of background studies. This book presents taxonomic descriptions for about 500 species and subspecies from the Black Sea, Sea of Azov, Caspian Sea, Aral Sea, Sea of Marmara, and the Eastern Mediterranean. This catalogue is supplemented by ecological remarks, stratigraphic distributions, paleogeography, and environmental/paleoenvironmental applications, including responses to environmental stress, e.g., river discharge, pollution by different contaminants, etc. The book will be useful to specialists in Quaternary history of the “CORRIDORS” as well as those in environmental monitoring and risk assessment. This handbook offers detailed taxonomic descriptions of foraminifera from the Black Sea, Caspian Sea, Sea of Azov, Aral Sea (in Volume 1) and Eastern Mediterranean and Sea of Marmara (in Volume 2). .
    Type of Medium: Online Resource
    Pages: XXI, 419 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031123740
    DDC: 560
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Computational intelligence. ; Bioinformatics. ; Biotechnology. ; Computational Intelligence. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Feature engineering and computational intelligence in ECG monitoring – an introduction -- Chapter 2. Representative Databases for Feature Engineering and Computational Intelligence in ECG Processing -- Chapter 3. An Overview of signal quality indices on dynamic ECG signal quality assessment -- Chapter 4. Signal quality features in dynamic ECGs -- Chapter 5. Motion Artifact Suppression Method in Wearable ECG -- Chapter 6. Data Augmentation for Deep Learning based ECG analysis -- Chapter 7. Study on Automatic Classification of Arrhythmias -- Chapter 8. ECG Interpretation with deep learning -- Chapter 9. Visualizing ECG contribution into Convolutional Neural Network classification -- Chapter 10. Atrial fibrillation detection in dynamic signals -- Chapter 11. Applications of Heart rate variability in Sleep Apnea -- Chapter 12. False Alarm Rejection for ICU ECG Monitoring -- Chapter 13. Respiratory Signal Extraction from ECG Signal -- Chapter 14. Noninvasive Recording of Cardiac Autonomic Nervous Activity--What’s behind ECG? -- Chapter 15. A questionnaire study on artificial intelligence and its effects on individual health and wearable device.
    Abstract: This book discusses feature engineering and computational intelligence solutions for ECG monitoring, with a particular focus on how these methods can be efficiently used to address the emerging challenges of dynamic, continuous & long-term individual ECG monitoring and real-time feedback. By doing so, it provides a “snapshot” of the current research at the interface between physiological signal analysis and machine learning. It also helps clarify a number of dilemmas and encourages further investigations in this field, to explore rational applications of feature engineering and computational intelligence in ECG monitoring. The book is intended for researchers and graduate students in the field of biomedical engineering, ECG signal processing, and intelligent healthcare.
    Type of Medium: Online Resource
    Pages: X, 268 p. 101 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811538247
    DDC: 660.6
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Medical care. ; Quantitative research. ; Artificial intelligence Data processing. ; Health services administration. ; Bioinformatics. ; Biomedical Research. ; Health Care. ; Data Analysis and Big Data. ; Data Science. ; Health Care Management. ; Bioinformatics.
    Description / Table of Contents: 1. AI and Big Data for Intelligent Health: Promise and Potential -- 2. AI and Big Data for Cancer Segmentation, Detection and Prevention -- 3. Radiology, AI and Big Data: Challenges and Opportunities for Medical Imaging -- 4. Neuroradiology: Current Status and Future Prospects -- 5. Big Data and AI in Cardiac Imaging -- 6. Artificial Intelligence and Big data for COVID-19 Diagnosis -- 7. AI and Big Data for Drug Discovery -- 8. Blockchain of IoMT (BIoMT): A New Paradigm for COVID-19 Pandemic: Application, Architecture, Technology, and Security -- 9. AI and Big Data for Therapeutic Strategies in Psychiatry -- 10. Distributed Learning in Healthcare -- 11. Cybersecurity in Healthcare -- 12. Radiology and Radiomics: Towards oncology Prediction with IA and Big Data.
    Abstract: This book aims to present the impact of Artificial Intelligence (AI) and Big Data in healthcare for medical decision making and data analysis in myriad fields including Radiology, Radiomics, Radiogenomics, Oncology, Pharmacology, COVID-19 prognosis, Cardiac imaging, Neuroradiology, Psychiatry and others. This will include topics such as Artificial Intelligence of Thing (AIOT), Explainable Artificial Intelligence (XAI), Distributed learning, Blockchain of Internet of Things (BIOT), Cybersecurity, and Internet of (Medical) Things (IoTs). Healthcare providers will learn how to leverage Big Data analytics and AI as methodology for accurate analysis based on their clinical data repositories and clinical decision support. The capacity to recognize patterns and transform large amounts of data into usable information for precision medicine assists healthcare professionals in achieving these objectives. Intelligent Health has the potential to monitor patients at risk with underlying conditions and track their progress during therapy. Some of the greatest challenges in using these technologies are based on legal and ethical concerns of using medical data and adequately representing and servicing disparate patient populations. One major potential benefit of this technology is to make health systems more sustainable and standardized. Privacy and data security, establishing protocols, appropriate governance, and improving technologies will be among the crucial priorities for Digital Transformation in Healthcare.
    Type of Medium: Online Resource
    Pages: X, 251 p. 67 illus., 64 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031111990
    Series Statement: Integrated Science, 9
    DDC: 610.72
    Language: English
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    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Immunology. ; Bioinformatics. ; Biotechnology. ; Cytokines. ; Immunology. ; Computational and Systems Biology. ; Biotechnology. ; Cytokines and Growth Factors. ; Chemical Bioengineering.
    Description / Table of Contents: Chapter 1: Vaccine design, nanoparticle vaccines and biomaterial applications -- Chapter 2: Systems Immunology approach in understanding the association of allergy and cancer -- Chapter 3: Genome Engineering Tools in Immunotherapy -- Chapter 4: Bioinformatics tools for Epitope Prediction. Chapter 5: A chronological journey of Breg subsets: Implications in health and disease -- Chapter 6: T-cell activation and differentiation: Role of signaling and metabolic crosstalk -- Chapter 7: Innate immune signaling in cardiac homeostasis and cardiac injuries -- Chapter 8: . Role of Regulatory T lymphocytes in Health and Disease -- Chapter 9: Implication of Synthetic Biology in Biotherapeutics Engineering -- Chapter 10. Cytokines in Cancer Immunotherapy.
    Abstract: Systems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology. The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.
    Type of Medium: Online Resource
    Pages: VII, 269 p. 31 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811533501
    DDC: 571.96
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Ecology . ; Biomathematics. ; Bioinformatics. ; Biotic communities. ; Population biology. ; Theoretical and Statistical Ecology. ; Mathematical and Computational Biology. ; Computational and Systems Biology. ; Community and Population Ecology.
    Description / Table of Contents: Part 1. Intra-specific trait diversity -- Chapter 1. Incorporating ontogenetic niche shifts into hybrid community dynamics -- Chapter 2. Effects of rapid evolution on population cycles and extinction in predator-prey systems -- Chapter 3. The possibility that the evolution of sexual traits stabilizes ecological communities -- Chapter 4. Spatiality and community stability -- Part 2. Inter-specific trait and functional diversity -- Chapter 5. Direct and Indirect Effects of Facilitation and Competition in Ecological -- Chapter 6. Mathematical modeling on microbes and their roles in community and ecosystem: how to handle microbial diversity in modeling? -- Part 3. Diversity of inter-specific interaction -- Chapter 7. Ecology and evolution of density-dependence -- Chapter 8. Interaction-type diversity and community stability -- Part 4. A novel approach in community ecology -- Chapter 9. Forecasting ecological time series using empirical dynamic modeling: a tutorial for simplex projection and S-map. .
    Abstract: This book presents new theoretical perspectives on ecological community dynamics and in so doing casts fresh light on the enduring complexity–stability debate. Real ecological communities do not simply comprise diverse species and interactions, which respectively represented the nodes and links of the classic network theory. Rather, they are characterized by different types of complexity, and this book explains how this diversity of complexity is key to understanding the dynamics of ecological communities. It is shown how various properties in natural communities, such as life history, adaptation, density dependence, sex, interaction types, space, functional traits, and microbial processes, can dramatically increase the complexity in ecological communities. Furthermore, innovative methods are introduced that may be applied to cast light on very complex communities. With each chapter presenting the latest advances and approaches, the book sets the direction for future research on ecological community dynamics. It will be a “must read” for researchers and students in the field of ecology.
    Type of Medium: Online Resource
    Pages: VIII, 213 p. 72 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811579530
    Series Statement: Theoretical Biology,
    DDC: 577.01
    Language: English
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    Keywords: Cytology. ; Stress (Physiology). ; Bioinformatics. ; Cytology Technique. ; Cellular Stress. ; Computational and Systems Biology. ; Cytological Techniques.
    Description / Table of Contents: Introduction -- Assays for thiols and modifications -- Pitfalls of ROS measurements by fluorescent probes and mitochondrial superoxide determination using MitoSOX -- Methods and Reagents -- Clinical Probes for ROS and Oxidative Stress -- Measurement of oxidative stress markers in vitro using commercially available kits -- Oxidative Lipidomics - Analysis of Oxidized Lipids and Lipid Peroxidation in Biological Systems with Relevance to Health & Disease -- Clinically Related Models and Approaches -- Oxidant-Induced Models of Vascular Leak -- Ozone-Specific’ Oxysterols and Neuronal Cell Signaling -- Measurement Oxidative Stress Status in Human Populations: A Critical Need for a Metabolomic Approach -- Instrumental Methods -- Sense and Sensibility of Oxygen in Pathophysiology using EPR Oximetry -- Resonators for Clinical EPR -- Biomedical Overhauser Magnetic Resonance Imaging (OMRI). Noninvasive Imaging of Redox Processes -- Index.
    Abstract: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
    Type of Medium: Online Resource
    Pages: XIV, 237 p. 85 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030473181
    Series Statement: Biological Magnetic Resonance, 34
    DDC: 571.6
    Language: English
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  • 75
    Keywords: Medicine Research. ; Biology Research. ; Biochemistry. ; Internal medicine. ; Lipids. ; Bioinformatics. ; Medical genetics. ; Biomedical Research. ; Chemical Biology. ; Internal Medicine. ; Lipidology. ; Computational and Systems Biology. ; Medical Genetics.
    Description / Table of Contents: Sterols from the post-lanosterol part of cholesterol synthesis – novel signaling players -- Genetic variability in cholesterol metabolism -- Side-chain oxidized oxysterols in health and disease -- Bile acids and TGR5 (Gpbar1) signaling -- Bile acids as regulatory signalling molecules -- Oxysterols and bile acid act as signaling molecules that regulate cholesterol homeostasis: nuclear receptors LXR, FXR, and fibroblast growth factor 15/19 -- Cytochrome P450 Metabolism Leads to Novel Biological Sterols and Other Steroids.
    Abstract: This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as medical doctors in hepatology.
    Type of Medium: Online Resource
    Pages: V, 171 p. 57 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030396848
    DDC: 610.72
    Language: English
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    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biotechnology. ; Bioinformatics. ; Biotechnology. ; Computational and Systems Biology.
    Description / Table of Contents: Virtual Anatomy Museum – Facilitating Public Engagement Through An Interactive Application -- E-Learning And Embryology; Designing An Application To Improve 3D Comprehension Of Embryological Structures -- Animated Guide to Represent A Novel Means of Gut-brain Axis Communication -- Engaging with Children using Augmented Reality on Clothing to Prevent them from Smoking -- Enabling More Accessible MS Rehabilitation Training Using Virtual Reality -- The Use of Augmented Reality to Raise Awareness of the Differences between Osteoarthritis and Rheumatoid Arthritis -- Understanding the Brain and Exploring the Effects of Clinical Fatigue: From A Patient’s Perspective -- A Methodology for Visualising Growth and Development of the Human Temporal Bone -- Collect the Bones, Avoid the Cones: A Game-Based App for Public Engagement -- A Serious Game on Skull Anatomy for Dental Undergraduates. .
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences, with a focus in this volume related to anatomy, and clinically applied scenarios. All chapters in this volume feature collaborative and innovative postgraduate research projects from graduate students of the MSc Medical Visualisation and Human Anatomy. This pioneering, world-leading postgraduate taught degree program is a joint partnership degree between the School of Life Sciences within the College of Medical, Veterinary and Life Sciences in the University of Glasgow, and the School of Simulation and Visualisation, The Glasgow School of Art. These chapters truly showcase the amazing and diverse technological applications that have been carried out as part of their research projects.
    Type of Medium: Online Resource
    Pages: XVI, 237 p. 268 illus., 238 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030439613
    Series Statement: Advances in Experimental Medicine and Biology, 1262
    DDC: 660.6
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Bioinformatics. ; Biotechnology. ; Molecular genetics. ; Medical genetics. ; Electronic circuits. ; Computational and Systems Biology. ; Chemical Bioengineering. ; Molecular Genetics. ; Medical Genetics. ; Electronic Circuits and Systems.
    Description / Table of Contents: Chapter 1. Introduction to Synthetic Biology -- Chapter 2. Current progress in synthetic genetic networks -- Chapter 3. Current Progress and Limitations in the Design, Construction and Characterization of Synthetic Parts -- Chapter 4. Recent progress in DNA parts standardization and characterization -- Chapter 5. Current status and challenges of DNA sequencing -- Chapter 6. Biomimetic approaches in synthetic biology -- Chapter 7. Design principles of synthetic biological oscillators -- Chapter 8. SOFTWARE-AIDED DESIGN OF IDEALISED PROGRAMMABLE NUCLEIC ACID CIRCUITS -- Chapter 9. Digital Circuit Design for Biological and Silicon Computers -- Chapter 10. Engineering of riboregulators for gene regulation as a tool for synthetic biology -- Chapter 11. Recent advances, challenges and opportunities in riboswitches -- Chapter 12. Recent Advances in Gene and Genome Assembly: Challenges and Implications -- Chapter 13. Recent advances, challenges and opportunities in synthetic genomes -- Chapter 14. Expansion of the genetic code -- Chapter 15. Expanding the potential of CRISPR-Cas9 technology for crops improvement -- Chapter 16. Synthetic biology at the hand of cell-free systems -- Chapter 17. Synthetic Biology for the Rapid, Precise and Compliant Detection of Microbes -- Chapter 18. Application and challenges of synthetic biology -- Chapter 19. Development and Application of Microfluidics in Synthetic Biology -- Chapter 20. The Ethics of Synthetic Biology Research and Development: A Principlist Approach. .
    Abstract: This book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists, clinicians, stakeholders and policymakers interested in the potential held by synthetic biology.
    Type of Medium: Online Resource
    Pages: XIII, 349 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811500817
    DDC: 570.285
    Language: English
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    Keywords: Cancer. ; Medical genetics. ; Pharmaceutical chemistry. ; Bioinformatics. ; Cancer Biology. ; Medical Genetics. ; Pharmaceutics. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. Phytochemicals in Cancer Chemoprevention: A Brief Perspective -- Chapter 2. Phytochemicals in Modulating Signalling Cascades in Cancer Cells -- Chapter 3. Diverse cancer therapeutic interactions: complexities in cancer management -- Chapter 4. Natural Products as Chemosensitizers for Adjunct Therapy in Cancer Management -- Chapter 5. Dietary phytochemicals as epigenetic modulators in cancer prevention: Emerging research trends, gaps, and future perspectives -- Chapter 6. Modulation of Cancer Cell Metabolism and Microenvironment by Phytochemicals -- Chapter 7. Role of Nutrigenetics and Nutrigenomics in Cancer Chemoprevention -- Chapter 8. Nano-delivery carriers for Enhanced Bioavailability of Antitumor Phytochemicals -- Chapter 9. Biphasic Effects of Phytochemicals and their Relevance to Cancer Therapeutics -- Chapter 10. Potential Pharmacotherapeutic Phytochemicals from Zingiberaceae for Cancer Prevention -- Chapter 11. 3 Dimensional Cell Culture Techniques in Cancer Research -- Chapter 12. Animal Models Systems of Cancer for Preclinical Trials -- Chapter 13. Cancer Chemoprevention by Natural Plant Products and Their Derivatives: Clinical Trials.
    Abstract: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.
    Type of Medium: Online Resource
    Pages: XII, 337 p. 120 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811559990
    DDC: 571.978
    Language: English
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    Keywords: Microbiology. ; Molecular genetics. ; Industrial microbiology. ; Bioinformatics. ; Microbiology. ; Molecular Genetics. ; Industrial Microbiology. ; Bioinformatics.
    Description / Table of Contents: Part 1. Introduction to Metagenomics -- Chapter 1. The New Science of Metagenomics: Revealing the Secrets of Microbial Physiology -- Chapter 2. The Coming Together of Sciences: Metagenomics for Microbial Biochemistry -- Part 2. Applications of Metagenomics -- Chapter 3. Metagenomic DNA sequencing: Technological Advances and Applications -- Chapter 4. Environmental Microbial Forensics- How Hidden is the Truth? -- Chapter 5. Metagenomics Analyses: A Qualitative Assessment Tool for Applications in Forensic Sciences -- Chapter 6. Realizing Bioremediation Through Metagenomics- A Technical Review -- Chapter 7. Metagenomics and Enzymes: The Novelty Perspective -- Chapter 8. Metagenomics and Drug-Discovery -- Chapter 9. Epidemiological Perspectives of Human Health through -- Metagenomic Research -- Chapter 10. Metagenomic Applications of Wastewater Treatment -- Chapter 11. Metagenomics in Agriculture: State-of-the-art -- Chapter 12. The Skin Metagenomes: Insights into Involvement of Microbes in Diseases -- Chapter 13. Computational Metagenomics: State-of-the-art, Facts and Artifacts.
    Abstract: This book summarizes the various areas of research in metagenomics and their potential applications in medicine, the environment and biotechnology. The book presents the recent advances in theoretical, methodological and applied aspects of metagenomics and highlights their applications in the fields of environmental microbial forensics, bioremediation, drug-discovery and agriculture. In addition, the book discusses various metagenomics approaches used for understanding the microbial physiology and biochemistry. Lastly the book describes a range of bioinformatics tools and computational methods for metagenomics analysis as well as the functional diversity and dynamics of microbial communities colonizing the human skin.
    Type of Medium: Online Resource
    Pages: VIII, 227 p. 35 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811565298
    DDC: 579
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Bioinformatics. ; Pharmaceutical chemistry. ; Geriatrics. ; Protein Biochemistry. ; Computational and Systems Biology. ; Pharmaceutics. ; Geriatrics.
    Description / Table of Contents: Ch-01 Targeting ROS-mediated Crosstalk between Autophagy and Apoptosis in Cancer -- Ch-02 Micronutrients that Affect Immunosenescence -- Ch-03 Bioactive Lipids in Age-Related Disorders -- Ch-04 Effect of Short Chain Fatty Acids on Age-Related Disorders -- Ch-05 The Effects of Parabiosis on Aging and Age-related Diseases -- Ch-06 Skeletal Muscle Aging Atrophy: Assessment and Exercise-Based Treatment -- Ch-07 Polyphenols as an Effective Therapeutic Intervention Against Cognitive Decline during Normal and Pathological Brain Aging -- Ch-08 Early Diagnosis and Targeted Treatment Strategy for Improved Therapeutic Outcomes in Alzheimer’s Disease -- Ch-09 Resetting the Aging Clock: Implications for Managing Age-Related Diseases -- Ch-10 The Challenge of Antidepressant Therapeutics in Alzheimer's Disease -- Ch-11 Anxiolytic Terpenoids and Aromatherapy for Anxiety and Depression -- Ch-12 The Role of Nutrition in Attenuating Age-Related Skeletal Muscle Atrophy -- Ch-13 The Use of Metformin to Increase the Human Healthspan.
    Abstract: Aging is an inevitable part of life and is becoming a worldwide social, economic and health problem. This is mainly due to the fact that the increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders, such as type II diabetes mellitus, cardiovascular disorders, sarcopenia, and neurodegenerative conditions. New therapeutic approaches are still needed to decrease or slow the effects of such diseases. Advances in -omic technologies, such as genomics, transcriptomics, proteomics and metabolomics, have significantly advanced our understanding of disease in multiple medical areas, as the analysis of multiple molecular networks has simultaneously provided a more integrated view of disease pathways. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan. In turn, this will lead to new therapeutic strategies as well as drug development projects by the pharmaceutical industry. This book presents a series of reviews describing studies that have resulted in identification of new potential drug targets for age-related disorders. Much of this information has come from -omic comparisons of healthy and disease states or from testing the effects of new therapeutic approaches. Authored by experts from around the globe, each chapter is presented in the context of specific chronic diseases or therapeutic strategies. This book is designed for researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians and stakeholders in major drug companies. .
    Type of Medium: Online Resource
    Pages: VIII, 340 p. 52 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030426675
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1260
    DDC: 572.6
    Language: English
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    Keywords: Biotechnology. ; Geriatrics. ; Medicine Research. ; Biology Research. ; Medical genetics. ; Bioinformatics. ; Regenerative medicine. ; Biotechnology. ; Geriatrics. ; Biomedical Research. ; Medical Genetics. ; Computational and Systems Biology. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: PART I ~ ALTERATIONS IN CELLULAR MECHANISMS DURING AGING -- Chapter 1 Protein Structure and Function in Aging and Age-related Diseases -- Chapter 2 DNA, DNA Replication and Aging -- Chapter 3 Transcription and Aging -- Chapter 4 Ribosomes, Translation and Aging -- Chapter 5 p53 and Aging -- Chapter 6 Paired Box (Pax) Transcription Factors and Aging -- Chapter 7 Telomeres, Telomerase and Aging -- Chapter 8 The Epigenome of Ageing -- Chapter 9 Attaining Epigenetic Rejuvenation: Challenges Ahead -- Chapter 10 Mitochondria as a Key Player in Aging -- Chapter 11 Aging, Free Radicals and Reactive Oxygen Species: An Evolving Concept -- Chapter 12 Stem Cells and Aging -- Chapter 13 Can Autophagy Stop the Clock: Unravelling the Mystery in Dictyostelium discoideum -- Chapter 14 Aging: Reading, Reasoning and Resolving Using Drosophila as a Model System -- Chapter 15 Nothobranchius furzeri as a New Model System for Aging Studies -- PART II ALTERATIONS IN METABOLISM DURING AGING AND DISEASES -- Chapter 16 Aging in Muscle -- Chapter 17 Metabolic Diseases and Aging -- Chapter 18 Interplay Between Nutrient Sensing Molecules During Aging and Longevity -- Chapter 19 Protein Aggregation, Related Pathologies and Aging -- Chapter 20 Biological Rhythms and Aging -- Chapter 21 The Biology of Ageing and Cancer – A Complex Association.
    Abstract: The book deals with basic cellular and molecular mechanisms associated with aging. It comprehensively describes the important genetic, epigenetic, biochemical and metabolic regulations during aging, as well as some important age-related diseases.The book is divided into four major sections for easy understanding. It takes the readers through the various aspects of aging in a story-like manner. Certain interventions for healthy aging such as dietary restriction, regular exercise and maintaining a balanced and peaceful life-style are also suggested by the experts. The book would be a companion for both beginners, as well as established researchers in the field. It would be useful for science education, research, clinical approach and policy making.
    Type of Medium: Online Resource
    Pages: XIII, 497 p. 77 illus., 70 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789813290051
    DDC: 660.6
    Language: English
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    Keywords: Bacteria. ; Bioinformatics. ; Microbial ecology. ; Microbial genetics. ; Bacteria. ; Computational and Systems Biology. ; Microbial Ecology. ; Microbial Genetics.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Talking about talking microbes -- Chapter 3. Mathematical models of quorum sensing molecular mechanisms -- Chapter 4. Mathematical models of quorum sensing regulated biofilms development -- Chapter 5. Mathematical models of bacterial swarming behaviour regulated by quorum sensing. Chapter 6. Mathematical models of bacterial quorum sensing regulated virulence factors -- Chapter 7. Evolutionary models of bacterial communication systems -- Chapter 8. Pattern formation in bacterial conversation mechanisms -- Chapter 9. Summary of Experimental Results -- Chapter 10. Therapy related mathematical models and quorum quenching -- Chapter 11. Role of noise in microbial communication -- Chapter 12. Electrical communication systems in bacterial biofilms and ion-channels -- Chapter 13. Synthetic biology and microbial communication -- Chapter 14. Role of Noise in Synthetic Biology.-Chapter 15 Noise in Science and Technology Vs Biological System.
    Abstract: This book introduces the concept of bacterial communication systems from a mathematical modeling point of view. It sheds light on the research undertaken in the last three decades, and the mathematical models that have been proposed to understand the underlying mechanism of such systems. These communication systems are related to quorum sensing mechanisms and quorum sensing regulated processes such as biofilm formation, gene expression, bioluminescence, swarming and virulence. The book further describes the phenomenon of noise, and discusses how noise plays a crucial role in gene expression and the quorum sensing circuit operationusing a set of tools like frequency domain analysis, power spectral density, stochastic simulation and the whitening effect. It also explores various aspects of synthetic biology (related to bacterial communication), such as genetic toggle switch, bistable gene regulatory networks, transcriptional repressor systems, pattern formation, synthetic cooperation, predator-prey synthetic systems, dynamical quorum sensing, synchronized quorum of genetic clocks, role of noise in synthetic biology, the Turing test and stochastic Turing test.
    Type of Medium: Online Resource
    Pages: XVII, 175 p. 35 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811574177
    DDC: 579.3
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Bioinformatics. ; Genetics. ; Molecular biology. ; Computational and Systems Biology. ; Genetics and Genomics. ; Molecular Biology.
    Description / Table of Contents: New Therapeutic Approaches and Biomarkers for Increased Healthspan -- Targeting Cancer Metabolism and Current Anti-Cancer Drugs -- A Review of Monoclonal Antibody-based Treatments in Non-small Cell Lung Cancer -- Parkinson’s Disease and Impairment in Mitochondrial Metabolism: A Pathognomic Signature -- Targeted Treatment of Age-related Fibromyalgia with Supplemental Coenzyme Q10 -- Immunoregulatory Effects of Tolerogenic Probiotics in Multiple Sclerosis -- Multifaceted Roles of Long Non-coding RNAs in Head and Neck Cancer -- A Systematic Review on the Genotoxic Effects of Selective Serotonin Reuptake Inhibitors -- Towards a New Era for the Management of Circulating Tumor Cells -- Telomerase: A target for Therapeutic Effects of Curcumin in Cancer -- Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence -- Targeting Stem Cells in Chronic Inflammatory Diseases -- Therapeutic Strategies and Nano-drug Delivery Applications in Management of Aging Alzheimer's Disease -- Psychometric Evaluation of Stress in 17,414 Critical Care Unit Nurses: Effects of Age, Gender and Working Conditions -- Targeting Age-related Neurodegenerative Diseases by AAV Mediated Gene Therapy -- Is Adipose Tissue the Fountain of Youth? The impact of Adipose Atem Cell Aging on Metabolic Homeostasis, Longevity and Cell-Based Therapies -- Proteomics for Target Identification in Psychiatric and Neurodegenerative Disorders -- Index.
    Abstract: Aging is an inevitable part of life, and is becoming a worldwide social, economic and health problem due to the fact that an increasing proportion of individuals in the advanced age category have a higher probability of developing age-related disorders. New therapeutic approaches are still in need to decrease or slow the effects of such diseases in this aging society. Advances in ‘omic technologies such as genomics, transcriptomics, proteomics and metabolomics have significantly advanced our understanding of diseases in multiple medical areas. It is hoped that emerging hits from these analyses might be prioritized for further screening as potential novel drug targets for increasing the human healthspan in line with the lifespan, which will in turn lead to new therapeutic strategies and drug development projects by the pharmaceutical industry.This new book presents a series of reviews describing studies which have resulted in the identification of potential new drug targets for age-related disorders. Much of this information has come from ‘omic comparisons of healthy and disease states or from testing the effects of potential new therapeutic approaches. Each chapter will be presented in the context of specific chronic diseases or different therapeutic strategies, providing important information on disease mechanisms related to the aging process. This book will be of interest to researchers in the areas of aging and chronic disease, as well as clinical scientists, physicians, and major drug companies. With contributors from Australia, Brazil, Canada, France, Germany, India, Iran, Iraq, South Africa, South Korea, Thailand, Ukraine, United Kingdom, United States of America,Uruguay and Vietnam, this is a timely follow up to Guest’s previous book Reviews on New Drug Targets in Age-Related Disorders.
    Type of Medium: Online Resource
    Pages: VIII, 272 p. 41 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030550356
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1286
    DDC: 570.285
    Language: English
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  • 84
    Keywords: Paleoecology. ; Agricultural ecology. ; Environment. ; Forestry. ; Bioinformatics. ; Paleoecology. ; Agroecology. ; Environmental Sciences. ; Forestry. ; Computational and Systems Biology.
    Description / Table of Contents: Chapter 1. Presentation and Work Guide -- Chapter 2. General identification keys -- Chapter 3. Atlas of the most common xylophagous insects.
    Abstract: This atlas presents a concrete tool to identify xylophagous activity by the remains they left in wooded areas in Western Europe. Xylophagous insects are among the largest predators of woody tissues. They leave discriminating traces, different for each species according to their bioecology, and so it is necessary to know how to recognize and characterize them. The book is a practical tool to help identify and interpret them through a standardized presentation of the most ubiquitous families and a key to their determination. It presents descriptions of the galleries and of morphometry of the faecal pellets based on macroscopic features for xylophagous identification, and includes information about the origin and distribution of the xylophagous biological cycles, bioclimatic conditions and bioecology, and the type of woods that are attacked. The book will be a useful guide for forest managers, heritage conservationists, environmental engineers, bioarchaeologists, entomologists, loggers, and wood anatomists. .
    Type of Medium: Online Resource
    Pages: XVII, 220 p. 464 illus., 288 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030663919
    DDC: 560.45
    Language: English
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  • 85
    Keywords: Biotechnology. ; Bioinformatics. ; Computer vision. ; Machine learning. ; Biotechnology. ; Bioinformatics. ; Computer Vision. ; Machine Learning.
    Description / Table of Contents: Chapter 1. An Integrated Design of Fuzzy C-Means and NCA based Multi-Properties Features Reduction for Brain Tumor Recognition -- Chapter 2. Hybrid Image Processing based Examination of 2D Brain MRI Slices to Detect Brain Tumour/Stroke Section – A Study -- Chapter 3. Edge Enhancing Coherence Diffusion Filter for Level Set Segmentation and Asymmetry Analysis using Curvelets in Breast Thermograms -- Chapter 4. Lung Cancer Diagnosis Based on Image Fusion and prediction using CT and PET image -- Chapter 5. Segmentation and Validation of Infrared Breast Images using Weighted Level Set and Phase Congruency Edge Map Framework -- Chapter 6. Analysis of Material Profile for Polymer Based Mechanical Microgripper for Thin Plate Holding -- Chapter 7. Design and Testing of Elbow Actuated Wearable Robotic Arm for Muscular Disorders -- Chapter 8. A Comprehensive Study of Image Fusion Techniques and Their Applications -- Chapter 9. Multilevel Mammogram Image Analysis for Identifying Outliers, Misclassification using Machine Learning -- Chapter 10. A Review on Automatic Detection of Retinal Lesions in Fundus Images for Diabetic Retinopathy -- Chapter 11. Medical Image Watermarking: A Review on Wavelet Based Methods -- Chapter 12. EEG Signal Extraction Analysis Techniques -- Chapter 13. Classification of sEMG Signal based Arm Action using Convolutional Neural Network -- Chapter 14. An Automated Approach for the Identification of TB Images Enhanced by Non-uniform Illumination Correction.
    Abstract: This book comprehensively reviews the various automated and semi-automated signal and image processing techniques, as well as deep-learning-based image analysis techniques, used in healthcare diagnostics. It highlights a range of data pre-processing methods used in signal processing for effective data mining in remote healthcare, and discusses pre-processing using filter techniques, noise removal, and contrast-enhanced methods for improving image quality. The book discusses the status quo of artificial intelligence in medical applications, as well as its future. Further, it offers a glimpse of feature extraction methods for reducing dimensionality and extracting discriminatory information hidden in biomedical signals. Given its scope, the book is intended for academics, researchers and practitioners interested in the latest real-world technological innovations.
    Type of Medium: Online Resource
    Pages: XIV, 283 p. 117 illus., 52 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811561412
    DDC: 660.6
    Language: English
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  • 86
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Pharmacology. ; Bioinformatics. ; Proteins. ; Pharmacology. ; Computational and Systems Biology. ; Proteins.
    Description / Table of Contents: 1 Computational Approaches in Drug Discovery and Design -- 2 Molecular Modeling of Proteins: Methods, Recent Advances and Future Prospects -- 3 Cavity/Binding Site Prediction Approaches, and their Applications -- 4 Role of ADMET Tools in Current Scenario; Application and Limitations -- 5 Database Resources for Drug Discovery -- 6 Molecular Docking and Structure-Based Drug Design -- 7 Molecular Dynamics Simulation of Protein and Protein-Ligand Complexes -- 8 Computational Approaches for Drug Target Identification -- 9 Computational Screening Techniques for Lead Design and Development -- 10 Advances in Pharmacophore Modeling and its Role in Drug Designing -- 11 In Silico Designing of Vaccines: Methods, Tools and Their Limitations -- 12 Machine learning Approaches to Rational Drug Design. .
    Abstract: This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.
    Type of Medium: Online Resource
    Pages: XIII, 306 p. 80 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811568152
    DDC: 615
    Language: English
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  • 87
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurochemistry. ; Bioinformatics. ; Medical genetics. ; Medical informatics. ; Public health. ; Psychiatry. ; Neurochemistry. ; Bioinformatics. ; Medical Genetics. ; Health Informatics. ; Public Health. ; Psychiatry.
    Description / Table of Contents: Why Are Suicide Rates Increasing in the United States? Towards a Multilevel Reimagination of Suicide Prevention?- Barriers for the Research, Prevention, and Treatment of Suicidal Behavior -- The Role of Epigenetic Dysregulation in Suicidal Behaviors -- Suicide: Genetics and Heritability -- Toward a Biosignature of Suicide Reattempt -- Sex, Gender, and Suicidal Behavior -- Neurocognition and the Suicidal Process -- Lipids and Suicide Risk -- Glutamine and New Pharmacological Targets to Treat Suicidal Ideation -- The Role of Opiates in Social Pain and Suicidal Behavior -- Sleep Disturbances and Suicidal Behavior -- Ecological Momentary Assessment for Monitoring Risk of Suicide Behavior.
    Abstract: This book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide. Suicidal behavior, perhaps, is the most complex behavior that combines biological, social, and psychological factors. A new frontier and new opportunities are opening with the technologies of data acquisition and data analysis. Personalized models based on digital phenotype could provide promising strategies for preventing suicide.
    Type of Medium: Online Resource
    Pages: X, 245 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030575748
    Series Statement: Current Topics in Behavioral Neurosciences, 46
    DDC: 612.8042
    Language: English
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  • 88
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Bioinformatics. ; Medical care. ; Medicine. ; Artificial intelligence. ; Computational and Systems Biology. ; Bioinformatics. ; Health Care. ; Clinical Medicine. ; Artificial Intelligence.
    Description / Table of Contents: Chapter 1_Big Data Analytics and AI for Healthcare -- Chapter 2_Genetics with Big Data and AI -- Chapter 3_AI and Big Data for next-generation sequencing -- Chapter 4_Artificial Intelligence for Computational Biology -- Chapter 5_Artificial intelligence and machine learning in clinical development -- Chapter 6_Big data analytics for personalized medicine -- Chapter 7_Generating and Managing Healthcare data with AI -- Chapter 8_Big Data and Artificial Intelligence for diseases -- Chapter 9_Artificial Intelligence and Big Data for Public Health -- Chapter 10_Biasness in Healthcare Big Data and Computational Algorithms -- Chapter 11_AI and ML in Healthcare: An Ethical perspective.
    Abstract: This book reviews the application of artificial intelligence and machine learning in healthcare. It discusses integrating the principles of computer science, life science, and statistics incorporated into statistical models using existing data, discovering patterns in data to extract the information, and predicting the changes and diseases based on this data and models. The initial chapters of the book cover the practical applications of artificial intelligence for disease prognosis & management. Further, the role of artificial intelligence and machine learning is discussed with reference to specific diseases like diabetes mellitus, cancer, mycobacterium tuberculosis, and Covid-19. The chapters provide working examples on how different types of healthcare data can be used to develop models and predict diseases using machine learning and artificial intelligence. The book also touches upon precision medicine, personalized medicine, and transfer learning, with the real examples. Further, it also discusses the use of machine learning and artificial intelligence for visualization, prediction, detection, and diagnosis of Covid -19. This book is a valuable source of information for programmers, healthcare professionals, and researchers interested in understanding the applications of artificial intelligence and machine learning in healthcare.
    Type of Medium: Online Resource
    Pages: XV, 228 p. 119 illus., 88 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811608117
    DDC: 570.285
    Language: English
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  • 89
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Proteins . ; Bioinformatics. ; Genetics. ; Urology. ; Nephrology. ; Cancer. ; Protein Biochemistry. ; Computational and Systems Biology. ; Genetics and Genomics. ; Urology. ; Nephrology. ; Cancer Biology.
    Description / Table of Contents: 1. Sample Preparation for High-Throughput Urine Proteomics Using 96-Well Polyvinylidene Fluoride (PVDF) Membranes -- 2. Kidney diseases: the age of molecular markers -- 3. Urinary Extracellular Vesicles Magic particles for biomarker discovery -- 4. Cardiac troponin T: the impact of posttranslational modifications on analytical immunoreactivity in blood up to the excretion in urine -- 5. Research Progress of Urine Biomarkers in the Diagnosis, Treatment, and Prognosis of Bladder Cancer -- 6. Urinary markers of podocyte dysfunction in chronic glomerulonephritis -- 7. On Research and Translation of Urinary Biomarkers -- 8. A Mechanistic-Based and Non-Invasive Approach to Quantify the Capability of Kidney to Detoxify Cysteine-Disulfides -- 9. Diagnosis of Fluorosis by analysis of fluoride content in body fluids using ion selective electrode method -- 10. Dioctophimosis: a Parasitic Zoonosis of Public Health Importance.
    Abstract: Translational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys. The text approaches urine biomarkers from a new perspective, incorporating up-to-date studies of mass-spectrometry-based biomarker discovery as well as the latest advances in personalized medicine. The integration of technology-driven techniques, such as OMICS also provides a unique opportunity for improved diagnostics accuracy of urinary-related diseases. For nephrologists and urologists looking for new approaches to well-known problems, this edited volume serves as a valuable guide.
    Type of Medium: Online Resource
    Pages: XV, 147 p. 49 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030639082
    Series Statement: Proteomics, Metabolomics, Interactomics and Systems Biology, 1306
    DDC: 572.6
    Language: English
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  • 90
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Genetics. ; Bioinformatics. ; Medicine Research. ; Biology Research. ; Genetics and Genomics. ; Bioinformatics. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. Next Generation Sequencing (NGS)- What can be sequenced? -- Opportunities and Perspectives of NGS Applications in Cancer Research -- Chapter 3. Library Construction for NGS -- Chapter 4. NGS Technologies -- Chapter 5. Computer Setup -- Chapter 6. Introduction to Command Line -- Chapter 7. NGS Data -- Chapter 8. Reference Genome -- Chapter 9. Alignment -- Chapter 10. Identification of Genetic Variants and de novo Mutations Based on NGS -- Chapter 11. Design and Analysis of RNA Sequencing Data -- Chapter 12. Design and Analysis of Epigenetics and ChIP-Sequencing Data -- APPENDIX.
    Abstract: This textbook provides step-by-step protocols and detailed explanations for RNA Sequencing, ChIP-Sequencing and Epigenetic Sequencing applications. The reader learns how to perform Next Generation Sequencing data analysis, how to interpret and visualize the data, and acquires knowledge on the statistical background of the used software tools. Written for biomedical scientists and medical students, this textbook enables the end user to perform and comprehend various Next Generation Sequencing applications and their analytics without prior understanding in bioinformatics or computer sciences.
    Type of Medium: Online Resource
    Pages: XII, 218 p. 54 illus., 51 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030624903
    Series Statement: Learning Materials in Biosciences,
    DDC: 576.5
    Language: English
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  • 91
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Bioinformatics. ; Biotechnology. ; Image processing Digital techniques. ; Computer vision. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Computational and Systems Biology. ; Biotechnology. ; Computer Imaging, Vision, Pattern Recognition and Graphics.
    Description / Table of Contents: Chapter 1. Pair-Matching Digital 3D Models Of Temporomandibular Fragments Using Mesh-To-Mesh Value Comparison And Implications For Commingled Human Remain Assemblages (Alana S. Acuff, Mara A. Karell, Konstantinos E. Spanakis, And Elena F. Kranioti) -- Chapter 2. Forensic Recreation And Visual Representation Of Greek Orthodox Church Saint, Eftichios of Crete (Nectarios Vidakis, Markos Petousis, Despoina Nathena, Elena F. Kranioti, Andreas Manios) -- Chapter 3. Virtual Trauma Analysis Of The 19th Century Severed Head Of The Greek Outlaw Stavrou (Elena F. Kranioti, Nikos Tsiatis, Kristina Frandson, Maria Stefanidou, Konstantinos Moraitis) -- Chapter 4. Using Computed Tomography (CT) Data To Build 3D Resources For Forensic Craniofacial Identification (Terrie Simmons-Ehrhardt, Catyana R.S. Falsetti, Anthony B. Falsetti) -- Chapter 5. Instructional Design Of Virtual Learning Resources For Anatomy Education (Nicolette S. Birbara, Nalini Pather) -- Chapter 6. Implementation Of Ultrasound In Anatomy Education (Claire Smith And Seb Barfoot) -- Chapter 7. What The Tech? The Management Of Neurological Dysfunction Through The Use Of Digital Technology (Caitlin Carswell And Paul M. Rea) -- Chapter 8. Teaching With Disruptive Technology: The Use Of Augmented, Virtual, And Mixed Reality (Hololens) For Disease Education (Zane Stromberga, Charlotte Phelps, Jessica Smith & Christian Moro) -- Chapter 9. “Inform the Head, Give Dexterity to the Hand, Familiarise the Heart”: Seeing and Using Digitised Eighteenth-Century Specimens in a Modern Medical Curriculum (Frances Osis) -- Chapter 10. Contact-Free Pulse Signal Extraction From Human Face Videos: A Review And New Optimised Filtering Approach (Muhammad Waqar, Reyer Zwiggelaar And Bernard Tiddeman).
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. In this volume, there are chapters which examine forensic and historical visualisation techniques and digital reconstruction, ultrasound, virtual learning resources and patient utilised software and hardware. The use of HoloLens as a disruptive technology is discussed as well as historical items as a feature in a modern medical curriculum. It concludes with a fascinating chapter on pulse extraction from facial videos. All in all, this volume has something for everyone whether that is faculty, students, clinicians and forensic practitioners, patients, or simply having an interest in one or more of these areas.
    Type of Medium: Online Resource
    Pages: XV, 202 p. 68 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030611255
    Series Statement: Advances in Experimental Medicine and Biology, 1317
    DDC: 610.72
    Language: English
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  • 92
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medical genetics. ; Bioinformatics. ; Veterinary medicine. ; Medical Genetics. ; Computational and Systems Biology. ; Medical Genetics. ; Computational and Systems Biology. ; Veterinary Science.
    Description / Table of Contents: Chapter 1_Introduction to Bioinformatics -- Chapter 2_Biological databases -- Chapter 3_Sequence Alignment -- Chapter 4_Molecular Evolution -- Chapter 5_Next-generation Sequencing -- Chapter 6_Structural Bioinformatics -- Chapter 7_Systems Biology -- Chapter 8_Statistical Computing in R -- Chapter 9_Clinical Bioinformatics -- Chapter 10_Agricultural Bioinformatics -- Chapter 11_Veterinary Bioinformatics -- Chapter 12_Future trends of Bioinformatics.
    Abstract: This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.
    Type of Medium: Online Resource
    Pages: XI, 234 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811642418
    DDC: 616.042
    Language: English
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  • 93
    Keywords: Paleontology . ; Earth sciences. ; Paleoecology. ; Bioinformatics. ; Paleontology. ; Earth Sciences. ; Paleoecology. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Introduction to the study of Greek Fossil Vertebrates -- 2-Introduction to the geology of Greece with emphasis on the Neogene -- 3-The fossil record of conodonts in Greece -- 4-The fossil record of ray-finned fishes (Actinopterygii) in Greece -- 5-The fossil otolith record of fishes (Vertebrata: Teleostei) in Greece -- 6-The fossil record of lizards and snakes (Reptilia: Squamata) in Greece -- 7-The fossil record of amphibians (Amphibia: Urodela and Anura) in Greece -- 8-The fossil record of crocodylians (Reptilia: Crocodylia) in Greece -- 9-The fossil record of turtles and tortoises (Reptilia: Testudines) in Greece -- 10-The fossil record of aardwarks (Mammalia: Tubulidentata: Orycteropodidae) in Greece -- 11-The fossil record of hyraxes (Mammalia: Pliohyracidae) in Greece -- 12-The fossil record of the Neogene Proboscidea (Mammalia) in Greece -- 13-The fossil record of contintental elephants and mammoths (Mammalia: Proboscidea: Elephantidae) in Greece -- 14-The fossil record of sea cows (Mammalia: Sirenia) in Greece -- 15-The fossil record of rodents (Mammalia: Rodentia) in Greece -- 16-The fossil record of hares, rabbits and pikas (Mammalia: Lagomorpha) in Greece -- 17-The fossil record of the Old World monkeys (Mammalia: Primates: Cercopithecidae) in Greece -- 18-The fossil record of the Miocene hominoids (Mammalia: Primates: Hominoidea) in Greece -- 19-The hominin fossil record from Greece.
    Abstract: This 2-volume set provides a state-of-the-art study of the fossil record and taxonomy of the main vertebrate groups from Greece. Greece stands between 3 continents and its vertebrate fossil record is of great importance for paleontological and evolutionary studies in Europe, Asia and Africa. Fossils from classic, world-famous localities (e.g., Pikermi, Samos) form an essential part of the collections of the most important museums in the world and have been studied by numerous scientists. Recent paleontological research led to the discovery and study of numerous new sites. The volumes contain a taxonomic review of all named and identified taxa, their taxonomic history and current status, as well as historical, phylogenetic and biogeographic information. Volume 1 contains a synopsis of the fossil record and taxonomy of important groups of vertebrates represented in the fossil record of Greece. The volume deals with some of the early splitting clades, including the basal and enigmatic conodonts and basal tetrapods like fishes, amphibians, and reptiles like lizards, snakes, crocodiles, turtles and tortoises. The second part of the volume deals with basal mammalian clades, some of which are quite characteristic for the fossil record of the country: aardwarks, hyraxes, proboscideans, elephants and mammoths, sea cows, rodents, and lagomorphs. The volume ends with special chapters on the primate fossil record of the country, including some of our most recent and distant relatives. .
    Type of Medium: Online Resource
    Pages: XXI, 710 p. 161 illus., 94 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030683986
    DDC: 560
    Language: English
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  • 94
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medical genetics. ; Bioinformatics. ; Neuroscience. ; Medical Genetics. ; Bioinformatics. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Attitudes and smoking prevalence among undergraduate students in central Greece -- 2-Care of patients with Alzheimer’s disease -- 3-Regulation of antioxidant enzymes levels in rat brain -- 4-NIRS-based assessment of cerebral oxygenation during high definition anodal transcranial direct current stimulation in patients with posttraumatic encephalopathy -- 5-Cerebral critical closing pressure at concomitant traumatic brain injury -- 6-The role of inflammatory biomarkers as a diagnostic tool for possible late-life cognitive decline and dementias -- 7-The Development of Antisense RNA Treatments using Engineered Protein Substrates -- 8-Biomarker-driven analysis using high-throughput approaches in neuroinflammation and neurodegenerative diseases -- 9-Sensitive and Stereo specific high-performance liquid chromatographic method for flurbiprofen in human plasma -- 10-Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study -- 11-Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological Voices in Parkinsonian Patients -- 12-Effects of an 8-Week Stress Management Program in Women with Breast Cancer: A Randomized Controlled Trial -- 13-The Rosenberg Self-Esteem Scale: Translation and Validation in the Greek Language in Adolescents -- 14-Stress system activation analysis in Greek female adolescents: a bioimpedance study -- 15-Kisspeptin and the genetic obesity interactome -- 16-The importance of diagnostic and prognostic biomarkers identification and classification towards understanding ALS pathogenesis -- 17-Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia -- 18-Ebola virus disease and current therapeutic strategies; A review -- 19-Hyperbaric Oxygen Therapy effect on “Kinesia Paradoxa” Brain Circuits -- 20-Early and Very Early GRIM19 and MCL1 Expression are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line -- 21-Phospholipid Fatty Acid Profile of Spirulina platensis -- 22-Chronic systemic inflammation measured by bioimpedance technology before and after sleeve gastrectomy: a feasibility study -- 23-Synthesis and Biological Evaluation Substituted Thiophene Derivatives -- 24-Force spectroscopy in mechanical protein domains unfolding -- 25-Investigating the genetic component of Parkinson’s Disease -- 26-Urticaria from the Neurodermatological Perspective: A Temporal Analysis of Urticaria and Cognition -- 27-Novel Low-Noise CMOS Bioamplifier for the Characterization of Neurodegenerative Diseases -- 28-The Kentucky Inventory of Mindfulness Skills in Greek Undergraduate and Postgraduate Students -- 29-Synthesis, in silico stuiesand biological evaluation of 1, 3 ,4 oxadiazino indole derivatives -- 30-Designing and screening of new schiff bases of indole derivatives for anti-bacterial activity by in-silico methods and docking studies -- 31-Use of vitamin D bolus in fortified juice for improving vitamin D status in children with Cerebral Palsy -- 32-Microbes and the games they play -- 33-Impurity Profiling and Identification of 2,6 diisopropylphenol by Raman spectroscopy -- 34-Cultural Accommodation of the Strengthening Families Program for Parents and Young Adolescents 10-14: Greek Phase I & II Study -- 35-The effect of nutrients on Alzheimer’s disease biomarkers: A metabolomic approach -- 36-The impact of exercising in the quality of life of people with Aementia-Alzheimer disease -- 37-Advanced Health Technologies and Nanotechnologies in Neurodegenerative Diseases -- 38-Phenotype and genotype study in a case of frontometaphyseal dysplasia 1 -- 39-Craniofacial and neurological phenotype in a case of oculodentodigital syndrome -- 40-Clinical and molecular study of common thrombophilia mutation prothrombin G20210A -- 41-Prenatal genetic testing for X-linked hypohidrotic ectodermal dysplasia -- 42-Preimplantation genetic testing for spastic paraplegia type 3 -- 43-Synthesis, anti-inflammatory activity and in-silico studies of some new 3-({P-DIMETHYLAMINO}BENZYLIDENE YDRAZINYLIDENE)-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES -- 44-Design, characterization and docking studies of some novel isatin derivatives for anticonvulsant and antidepressant activity -- 45-Skin mirrors Brain: A Chance for Alzheimer’s Disease Research -- 46-Mitochondrial homeostasis in neurodegeneration and ageing -- 47-The Alzheimer's Disease Chronicles: will evidence triumph over adversity? -- 48-Liposomes: Production Methods and Application in Alzheimer’s Disease -- 49-Developing Treatments for Alzheimer’s and Related Disorders with Precision Medicine: A Vision -- 50-Biomarkers and Precision Medicine in Alzheimer’s Disease -- 51-The role of microRNAs in thrombosis -- 52-Photo-oxygenation: an innovative new therapeutic approach against amyloidoses.
    Abstract: The 4th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. The relation between genetics and its effect on several diseases are thoroughly examined in this volume. This volume focuses on the sessions from the conference on Genetics and Neurodegenerative Diseases.
    Type of Medium: Online Resource
    Pages: XV, 435 p. 133 illus., 110 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030787875
    Series Statement: Advances in Experimental Medicine and Biology, 1339
    DDC: 612.8
    Language: English
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  • 95
    Keywords: Agriculture. ; Bioinformatics. ; Plant genetics. ; Agricultural genome mapping. ; Biometry. ; Agriculture. ; Bioinformatics. ; Plant Genetics. ; Agricultural Genetics. ; Biostatistics.
    Description / Table of Contents: Preface -- Chapter 1 -- General elements of genomic selection and statistical learning -- Chapter. 2 -- Preprocessing tools for data preparation -- Chapter. 3 -- Elements for building supervised statistical machine learning models -- Chapter. 4 -- Overfitting, model tuning and evaluation of prediction performance -- Chapter. 5 -- Linear Mixed Models -- Chapter. 6 -- Bayesian Genomic Linear Regression -- Chapter. 7 -- Bayesian and classical prediction models for categorical and count data -- Chapter. 8 -- Reproducing Kernel Hilbert Spaces Regression and Classification Methods -- Chapter. 9 -- Support vector machines and support vector regression -- Chapter. 10 -- Fundamentals of artificial neural networks and deep learning -- Chapter. 11 -- Artificial neural networks and deep learning for genomic prediction of continuous outcomes -- Chapter. 12 -- Artificial neural networks and deep learning for genomic prediction of binary, ordinal and mixed outcomes -- Chapter. 13 -- Convolutional neural networks -- Chapter. 14 -- Functional regression -- Chapter. 15 -- Random forest for genomic prediction.
    Abstract: This book is open access under a CC BY 4.0 license This open access book brings together the latest genome base prediction models currently being used by statisticians, breeders and data scientists. It provides an accessible way to understand the theory behind each statistical learning tool, the required pre-processing, the basics of model building, how to train statistical learning methods, the basic R scripts needed to implement each statistical learning tool, and the output of each tool. To do so, for each tool the book provides background theory, some elements of the R statistical software for its implementation, the conceptual underpinnings, and at least two illustrative examples with data from real-world genomic selection experiments. Lastly, worked-out examples help readers check their own comprehension. The book will greatly appeal to readers in plant (and animal) breeding, geneticists and statisticians, as it provides in a very accessible way the necessary theory, the appropriate R code, and illustrative examples for a complete understanding of each statistical learning tool. In addition, it weighs the advantages and disadvantages of each tool.
    Type of Medium: Online Resource
    Pages: XXIV, 691 p. 113 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030890100
    DDC: 630
    Language: English
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  • 96
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Medical genetics. ; Bioinformatics. ; Neuroscience. ; Medical Genetics. ; Bioinformatics. ; Computational and Systems Biology.
    Description / Table of Contents: 1-Attitudes and smoking prevalence among undergraduate students in central Greece -- 2-Care of patients with Alzheimer’s disease -- 3-Regulation of antioxidant enzymes levels in rat brain -- 4-NIRS-based assessment of cerebral oxygenation during high definition anodal transcranial direct current stimulation in patients with posttraumatic encephalopathy -- 5-Cerebral critical closing pressure at concomitant traumatic brain injury -- 6-The role of inflammatory biomarkers as a diagnostic tool for possible late-life cognitive decline and dementias -- 7-The Development of Antisense RNA Treatments using Engineered Protein Substrates -- 8-Biomarker-driven analysis using high-throughput approaches in neuroinflammation and neurodegenerative diseases -- 9-Sensitive and Stereo specific high-performance liquid chromatographic method for flurbiprofen in human plasma -- 10-Genotypic and Clinical Analysis of a Thalassemia Major Cohort: An Observational Study -- 11-Design and Validation of a New Diagnostic Tool for the Differentiation of Pathological Voices in Parkinsonian Patients -- 12-Effects of an 8-Week Stress Management Program in Women with Breast Cancer: A Randomized Controlled Trial -- 13-The Rosenberg Self-Esteem Scale: Translation and Validation in the Greek Language in Adolescents -- 14-Stress system activation analysis in Greek female adolescents: a bioimpedance study -- 15-Kisspeptin and the genetic obesity interactome -- 16-The importance of diagnostic and prognostic biomarkers identification and classification towards understanding ALS pathogenesis -- 17-Entropy in Cardiac Autonomic Nervous System of Adolescents with General Learning Disabilities or Dyslexia -- 18-Ebola virus disease and current therapeutic strategies; A review -- 19-Hyperbaric Oxygen Therapy effect on “Kinesia Paradoxa” Brain Circuits -- 20-Early and Very Early GRIM19 and MCL1 Expression are Correlated to Late Acquired Prednisolone Effects in a T-Cell Acute Leukemia Cell Line -- 21-Phospholipid Fatty Acid Profile of Spirulina platensis -- 22-Chronic systemic inflammation measured by bioimpedance technology before and after sleeve gastrectomy: a feasibility study -- 23-Synthesis and Biological Evaluation Substituted Thiophene Derivatives -- 24-Force spectroscopy in mechanical protein domains unfolding -- 25-Investigating the genetic component of Parkinson’s Disease -- 26-Urticaria from the Neurodermatological Perspective: A Temporal Analysis of Urticaria and Cognition -- 27-Novel Low-Noise CMOS Bioamplifier for the Characterization of Neurodegenerative Diseases -- 28-The Kentucky Inventory of Mindfulness Skills in Greek Undergraduate and Postgraduate Students -- 29-Synthesis, in silico stuiesand biological evaluation of 1, 3 ,4 oxadiazino indole derivatives -- 30-Designing and screening of new schiff bases of indole derivatives for anti-bacterial activity by in-silico methods and docking studies -- 31-Use of vitamin D bolus in fortified juice for improving vitamin D status in children with Cerebral Palsy -- 32-Microbes and the games they play -- 33-Impurity Profiling and Identification of 2,6 diisopropylphenol by Raman spectroscopy -- 34-Cultural Accommodation of the Strengthening Families Program for Parents and Young Adolescents 10-14: Greek Phase I & II Study -- 35-The effect of nutrients on Alzheimer’s disease biomarkers: A metabolomic approach -- 36-The impact of exercising in the quality of life of people with Aementia-Alzheimer disease -- 37-Advanced Health Technologies and Nanotechnologies in Neurodegenerative Diseases -- 38-Phenotype and genotype study in a case of frontometaphyseal dysplasia 1 -- 39-Craniofacial and neurological phenotype in a case of oculodentodigital syndrome -- 40-Clinical and molecular study of common thrombophilia mutation prothrombin G20210A -- 41-Prenatal genetic testing for X-linked hypohidrotic ectodermal dysplasia -- 42-Preimplantation genetic testing for spastic paraplegia type 3 -- 43-Synthesis, anti-inflammatory activity and in-silico studies of some new 3-({P-DIMETHYLAMINO}BENZYLIDENE YDRAZINYLIDENE)-1,3-DIHYDRO-2H-INDOLE-2-ONE DERIVATIVES -- 44-Design, characterization and docking studies of some novel isatin derivatives for anticonvulsant and antidepressant activity -- 45-Skin mirrors Brain: A Chance for Alzheimer’s Disease Research -- 46-Mitochondrial homeostasis in neurodegeneration and ageing -- 47-The Alzheimer's Disease Chronicles: will evidence triumph over adversity? -- 48-Liposomes: Production Methods and Application in Alzheimer’s Disease -- 49-Developing Treatments for Alzheimer’s and Related Disorders with Precision Medicine: A Vision -- 50-Biomarkers and Precision Medicine in Alzheimer’s Disease -- 51-The role of microRNAs in thrombosis -- 52-Photo-oxygenation: an innovative new therapeutic approach against amyloidoses.
    Abstract: The 5th World Congress on Genetics, Geriatrics, and Neurodegenerative Diseases Research (GeNeDis 2022) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. This volume focuses on the sessions from the conference on Neuroscientific Advances.
    Type of Medium: Online Resource
    Pages: XXXI, 673 p. 58 illus., 50 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031319860
    Series Statement: Advances in Experimental Medicine and Biology, 1425
    DDC: 612.8
    Language: English
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  • 97
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Biotechnology. ; Bioinformatics. ; Machine learning. ; Biotechnology. ; Computational and Systems Biology. ; Machine Learning. ; Bioinformatics.
    Description / Table of Contents: Chapter 1. A Brief Overview Of Applications Of Machine Learning In Life Sciences -- Chapter 2. Introduction To Artificial Intelligence (Ai) Methods In Biology -- Chapter 3. Machine Learning Methods -- Chapter 4. Introduction To Machine Learning Models -- Chapter 5. Model Selection Formachine Learning -- Chapter 6. Multivariate Methods In Machine Learning In The Context Of Biological Data -- Chapter 7. Dimensionality Reduction Methods In Machine Learning -- Chapter 8. Hidden Markov Method -- Chapter 9. Neural Network And Deep Learning. Chapter 10. Ethics In Machine Learning And Artificial Intelligence -- Chapter 11. Machine Learning And Life Sciences -- Chapter 12. Machine Learning And Negleced Tropical Diseases- Chapter 13. Machine Learning In Cardiovascular Diseases -- Chapter 14. Machine Learning And Diabetes -- Chapter 15. Machine Learning And Epilepsy -- Chapter 16. The Microsoft, Google, Facebook, Pytorch And Applications In Biology -- Chapter 17. Applications And Software Of Machine Learning And Ai In Medical Knowledge In Health -- Chapter 18. Cloud Computing Infrastructure In Healthcare Industry -- Chapter 19. Amazon Web Services (Aws) And Microsoft Azure In The Domain Of Life Sciences -- Chapter 20. Toxicity: An Introduction -- Chapter 21. Machine Learning (Ml) And Toxicity Studies. Chapter 22. Applications Of Machine Learning In Study Of Cell Biology -- Chapter 23. Genomics And Machine Learning -- Chapter 24. Cell Fate Analysis And Machine Learning -- Chapter 25. Study Of Biomarker And Machine Learning -- Chapter 26. Animal Behaviour: An Introduction -- Chapter 27. Study Of Animal Behaviour And Machine Learning -- Chapter 28. Machine Learning And Precision Farming -- Chapter 29. Machine Learning In The Study Of Animal Health And Veterinary Sciences -- Chapter 30. Macinelearning And Animalresorviors -- Chapter 31. Challenging Problems In Plant Biology -- Chapter 32. Machine Learning And Plant Sciences. Chapter 33. Machine Learning In Understanding Of Plant Pathogen Interactions -- Chapter 34. Machine Learning In Plant Disease Research -- Chapter 35. Biorobots -- Chapter 36. The Challenges To Application Of Machine Learning In Biological Sciences -- Chapter 37. The Future Of Machine Learning.
    Abstract: This book gives an overview of applications of Machine Learning (ML) in diverse fields of biological sciences, including healthcare, animal sciences, agriculture, and plant sciences. Machine learning has major applications in process modelling, computer vision, signal processing, speech recognition, and language understanding and processing and life, and health sciences. It is increasingly used in understanding DNA patterns and in precision medicine. This book is divided into eight major sections, each containing chapters that describe the application of ML in a certain field. The book begins by giving an introduction to ML and the various ML methods. It then covers interesting and timely aspects such as applications in genetics, cell biology, the study of plant-pathogen interactions, and animal behavior. The book discusses computational methods for toxicity prediction of environmental chemicals and drugs, which forms a major domain of research in the field of biology. It is of relevance to post-graduate students and researchers interested in exploring the interdisciplinary areas of use of machine learning and deep learning in life sciences.
    Type of Medium: Online Resource
    Pages: XXI, 336 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811688812
    DDC: 660.6
    Language: English
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  • 98
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Alternative medicine. ; Bioinformatics. ; Pharmacy. ; Quantitative research. ; Complementary and Alternative Medicine. ; Bioinformatics. ; Pharmacy. ; Data Analysis and Big Data.
    Description / Table of Contents: Chapter 1. Introduction to multi-omics data and analytical methods for TCM and diseases -- Chapter 2. TCM and diseases: the needs for multi-omics -- Chapter 3. TCM related multi-omics data integration techniques -- Chapter 4. TCM related multi-omics data mining techniques -- Chapter 5. TCM preparation quality control: biological and chemical ingredient analysis -- Chapter 6. TCM preparation source tracking -- Chapter 7. TCM preparation network pharmacology analysis -- Chapter 8. TCM analysis data resources, web services and visualizations -- Chapter 9. TCM geoherbalism examination and authentic TCM identification.
    Abstract: This book focuses on the multi-omics big-data integration, the data-mining techniques and the cutting-edge omics researches in principles and applications for a deep understanding of Traditional Chinese Medicine (TCM) and diseases from the following aspects: (1) Basics about multi-omics data and analytical methods for TCM and diseases. (2) The needs of omics studies in TCM researches, and the basic background of omics research in TCM and disease. (3) Better understanding of the multi-omics big-data integration techniques. (4) Better understanding of the multi-omics big-data mining techniques, as well as with different applications, for most insights from these omics data for TCM and disease researches. (5) TCM preparation quality control for checking both prescribed and unexpected ingredients including biological and chemical ingredients. (6) TCM preparation source tracking. (7) TCM preparation network pharmacology analysis. (8) TCM analysis data resources, web services, and visualizations. (9) TCM geoherbalism examination and authentic TCM identification. Traditional Chinese Medicine has been in existence for several thousands of years, and only in recent tens of years have we realized that the researches on TCM could be profoundly boosted by the omics technologies. Devised as a book on TCM and disease researches in the omics age, this book has put the focus on data integration and data mining methods for multi-omics researches, which will be explained in detail and with supportive examples the “What”, “Why” and “How” of omics on TCM related researches. It is an attempt to bridge the gap between TCM related multi-omics big data, and the data-mining techniques, for best practice of contemporary bioinformatics and in-depth insights on the TCM related questions.
    Type of Medium: Online Resource
    Pages: IX, 139 p. 35 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811947711
    Series Statement: Translational Bioinformatics, 18
    DDC: 615.5
    Language: English
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  • 99
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biomedical engineering. ; Biomechanics. ; Regenerative medicine. ; Biotechnology. ; Bioinformatics. ; Biomedical Engineering and Bioengineering. ; Biomedical Devices and Instrumentation. ; Biomechanics. ; Regenerative Medicine and Tissue Engineering. ; Biotechnology. ; Bioinformatics.
    Description / Table of Contents: Biomedical engineering -- History and areas of expertise: Biomechanics, rehabilitation and assistive technology; Computational systems applied to health; Medical devices; and Applied Technologies -- Postural Control in Humans: Theories, Modeling, and Quantification -- Postural control in Parkinson's disease -- Narrative review on the application of additive manufacturing in the production of upper limb orthoses -- Digital health perspectives in biomedical engineering -- Health information management -- Supervised signal processing for neuroengineering -- Tissue engineering and regenerative medicine -- Natural hydrogels for drug delivery systems -- Techniques for estimating parameters of sinusoidal signals sampled in Electrical Impedance Tomography -- Basics of 3D Bioprinting by extrusion -- Optical techniques for the diagnosis and monitoring of oral hard tissue lesions -- 3D mapping of cardiac electrical activity -- Organs-on-a-chip and in vitro biological evaluation. .
    Abstract: This book brings together the latest updates from various subareas of biomedical engineering, providing readers with a broad overview of the current state of the art and the technological trends to be refined in the coming years with the goal of improving human health. It shows the important advances in each subfield, rehabilitation technology, computational systems applied to health, and medical devices, with practical examples. It includes topics not covered in other books in the area, such as digital health, bioprinting, organs-on-a-chip, the open data paradigm, and electrical impedance tomography. It is a short and easy-to-read book, and provides bibliographic references for the reader to go deeper into their areas of interest. This book is aimed at a very broad group of professionals and students in biomedical engineering and related areas, seeking to contextualize and understand the latest scientific advances in each subfield of biomedical engineering, including neuroengineering, regenerative medicine, additive manufacturing orthosis, postural analysis of Parkinson's patients, modelling and simulation using biomechanical open data, regenerative medicine, advanced drug delivery systems, bioprinting, biophotonic and electrical impedance tomography. .
    Type of Medium: Online Resource
    Pages: XVI, 290 p. 73 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031387432
    DDC: 610.28
    Language: English
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  • 100
    Keywords: Life sciences. ; Medicine Research. ; Biology Research. ; Biotechnology. ; Genetics. ; Bioinformatics. ; Biomedical engineering. ; Life Sciences. ; Biomedical Research. ; Biotechnology. ; Genetics and Genomics. ; Computational and Systems Biology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Introduction -- Epigenetics in Leukemia -- Genetic and Epigenetic Alterations in Leukemia -- Epigenetic Modifiers and Their Inhibitors in Leukemia Treatment -- Chromatin Remodeling during Leukemia Cell Proliferation and Differentiation -- DNA Methylation and Epigenetic Regulation -- Chromatin Functional Regulation by Histone Modification -- Approaches to Epigenetic Treatment of Leukemia -- Proteomics in Leukemia -- Proteome in Leukemic vs. Differentiated Leukemia Cells -- Protein Phosphorylation in Leukemia -- Computational Methods for Proteome Analysis -- 2DE Fractionation and Visualization -- Proteomic Data Processing -- Proteomic Data Analysis -- Image Acquisition and Data Analysis -- Image Acquisition and Data Analysis -- Protein Localization in Leukemia -- Protein Translocation into the Nucleus during Leukemia Cell Differentiation -- Protein Visualization in Leukemic Cells -- Computational Methods for Protein Localization Estimation -- Fluorescent Image Processing -- Fluorescent Image Acquisition and Analysis -- Future Therapy in Leukemia -- Index.
    Abstract: This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia. In particular, epigenetic modifiers and their inhibitors in leukemia treatment as well as approaches to the epigenetic treatment of leukemia are covered. Various computational methods for proteome analysis are also described in detail, including 2DE fractionation and visualization, proteomic data processing, image acquisition and data anlaysis, and more. Protein localization in leukemia is also covered, in addition to the future of leukemia therapy. Epigenetics and Proteomics of Leukemia is an ideal book for advanced biomedical scientists and students, medical doctors and students, bioinformatics and health informatics researchers, computational biologists, structural biologists, systems biologists, and bioengineers.
    Type of Medium: Online Resource
    Pages: LIX, 406 p. 156 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030687083
    DDC: 570
    Language: English
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