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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Radiology. ; Spectrum analysis. ; Pharmaceutical chemistry. ; Nutrition   . ; Biomedical Research. ; Radiology. ; Spectroscopy. ; Pharmaceutics. ; Nutrition.
    Description / Table of Contents: Ch 1: Electron Spin Resonance- An Introdcution -- Ch 2: ESR – Applications in Healthcare and Pharmaceutical Science -- Ch 3: ESR Applications in Paleontology and Geochronology -- Ch 4: ESR Applications in Food Science.
    Abstract: This book introduces the audience with basic theoretical and experimental aspects of Electron Spin Resonance (ESR) Spectroscopy. It further talks about ESR spectroscopy applications in Healthcare & Pharmaceutical Science, Paleontology & Geochronology and Food Science. Mathematical details have been kept to a necessary minimum and emphasis is given to highlight the applications of the technique.
    Type of Medium: Online Resource
    Pages: X, 72 p. 32 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641986
    Series Statement: Techniques in Life Science and Biomedicine for the Non-Expert,
    DDC: 610.72
    Language: English
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Hematology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Hematology.
    Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.
    Abstract: It has been 10 years since the first edition of ‘Essentials of Tissue Banking’ has been published. There is still relatively little published on the technical and scientific principles on routine tissue and cell banking based on scientific principles. The 1st edition was very successful and, after a 10 year gap, there is a need of an update and an expansion of the book’s remit. The format of the book follows that of the previous edition- split into 5 sections. Management of donors and the banking of common tissues and cells; Principles of storage and processing of tissues and cells; Ensuring the safety of the products by testing the donor, the tissues and the environment, supported by a quality system and an IT infrastructure- all working within the constraints of current regulatory and ethical environments. This edition however provides a significant update. Many the chapters have been completely rewritten by different experts. Like the 1st edition, they were given a free hand in the way they wrote their chapter, with a guideline that they had to be concise, clear and up to date. The authors were also asked to provide the scientific and technical basis that provides the rationale of the processes they describe. Also, the scope of the book has been somewhat extended. In view of the fact that many cellular therapies are now routinely practiced, 2 new chapters have been added: one on the banking of haematopoietic stem cells and one on human embryonic stem cells. They have been deliberately chosen to illustrate the extreme spectrum of cellular therapies from one of the simplest to one of the most complex. The intention of the book has remained the same: to cover and update banking of current practices in essential tissue and cell banking. It is therefore hoped that by keeping the book as concise and up to date as possible, it will find a place on the shelves of many tissue establishments.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 48 illus., 28 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030716219
    DDC: 610.72
    Language: English
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Reproductive health. ; Cytology. ; Biomedical Research. ; Reproductive Medicine. ; Cell Biology.
    Description / Table of Contents: Ch 1: The seminiferous epithelial cycle of spermatogenesis: Role of non-receptor protein kinases -- Ch 2: Sertoli cells: immunology and spermatogenesis -- Ch 3: Innate immunity and spermatogenesis -- Ch 4: Cell apoptosis and spermatogenesis -- Ch 5: Transcriptional regulation of spermatogenesis -- Ch 6: Sertoli cell cytoskeleton and spermatogenesis -- Ch 7: Leydig cell and spermatogenesis -- Ch 8: Cross-talk of cell junctions to support spermatogenesis -- Ch 9: Coordination of F-actin- and MT-based cytoskeletons to support spermatogenesis -- Ch 10: Regulation of the blood-testis barrier by basement membrane laminin-α2 chain -- Ch 11: Regulation of spermatogenesis by collagens -- Ch 12: Androgen regulation of spermatogenesis -- Ch 13: Use of molecular modeling to study spermatogenesis -- Ch 14: Acrosome biogenesis during spermatogenesis -- Ch 15: Stem cells and spermatogenesis -- Ch 16: Advances in our understanding of spermatogenesis in humans -- Ch 17: Leydig cell function in aging men -- Ch 18: Regulation of human spermatogenesis.
    Abstract: This new edition provides an update on the molecular mechanisms that regulate spermatogenesis. In addition to the rodent as a study model, chapters also include research on studies in humans. It includes the latest approaches of studying spermatogenesis, such as the use of bioinformatics, molecular modeling and others which are not commonly found in published materials. It also reviews the latest developments in the field, such as studies on the role of regulatory RNAs on spermatogenesis. Due to the declining fertility rate among men, a brand new chapter highlights the impact of environmental toxicants on spermatogenesis.
    Type of Medium: Online Resource
    Pages: X, 319 p. 44 illus., 40 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030777791
    Series Statement: Advances in Experimental Medicine and Biology, 1381
    DDC: 610.72
    Language: English
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  • 4
    Keywords: Medicine Research. ; Biology Research. ; Nutrition   . ; Food science. ; Chemistry, Organic. ; Biomedical Research. ; Nutrition. ; Food Science. ; Organic Chemistry.
    Description / Table of Contents: Part I: An overview of cancer and its mechanisms -- 1-A brief overview of cancer, its mechanisms, and prevention methods -- 2-MECHANISMS INVOLVED IN CARCINOGENESIS -- Part II: Functional foods/nutraceuticals as chemo preventive agents -- 3-Tomato (lycopene and β-carotene) and cancer -- 4-Essential Oils from Aromatic Plants in cancer prevention and treatment -- 5-Bee propolis (caffeic acid phenethyl ester) against cancer -- 6-Brown Algae (Fucoxanthin) Against Cancer -- 7-Cruciferous vegetables (indole-3-carbinol, isothiocyanates) against cancer -- 8-Crustacea (carotenoids namely astaxanthins) against cancer -- 9-Curcuma and breast cancer: a focus on cell signaling pathways -- 10-FRUITS AND VEGETABLES IN CANCER -- 11-Garlic: Allyl Sulfur Compounds and Cancer Prevention -- 12-Ginger (gingerols and 6-shogaol) against cancer -- 13-Saffron (crocins) against cancer -- 14-OLIVE LEAF (OLEUROPEIN) AND ITS ROLE IN CANCER: THERAPEUTIC UPDATES -- 15-Honey against cancer -- 16-Soybeans and phytoestrogen rich foods (genistein, daidzein) against cancer -- 17-Tea (catechins including (-)-epigallocatechin-3-gallate) and cancer -- 18-Probiotics and Cancer -- Part III: The role of nutrients in the prevention of cancer -- 19-Vitamins (C, D and E) against cancer -- 20-Minerals (namely selenium) and cancer -- 21-Dietary fibers/beta-glucan and cancer -- 22-Omega-3 Polyunsaturated Fatty Acids and Cancer.
    Abstract: Today's consumers are looking for food products with health-promoting roles in addition to nutritional benefits. With current research showing that nutraceuticals and functional foods rich in specific bioactives may have chemopreventative effects, these products are increasingly popular. However, while much in the literature supports the health-promoting features of these foods, few texts focus on their bioactive agents and their mode of action in cancer signaling. Nutraceuticals and Cancer Signalling: Clinical Aspects and Mode of Action explains the link between nutraceuticals and cancer in terms of clinical trials and modes of action. This book gives an overview of common cancers and their mechanisms, and the most common functional foods and their bioactive components. Individual chapters focus on specific functional foods--including tomatoes, garlic, honey, tea, yoghurt, and many more--their prominent bioactive compounds, and their mode of action in cancer signaling and chemoprevention. Recent findings on cancer-prevention roles of different vitamins and minerals are also discussed. For food scientists, nutritionists, and pharmaceutical experts looking to understand how functional foods can play a role in fighting cancer, this text serves as a one-stop reference.
    Type of Medium: Online Resource
    Pages: IX, 652 p. 52 illus., 36 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030740351
    Series Statement: Food Bioactive Ingredients,
    DDC: 610.72
    Language: English
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  • 5
    Keywords: Medicine Research. ; Biology Research. ; Diseases. ; Genetics. ; Immunology. ; Biomedical Research. ; Diseases. ; Genetics and Genomics. ; Immunology.
    Description / Table of Contents: Ch 1: Overview of Microbial NGS -- Ch 2: WGS for Bacterial Identification and Susceptibility Testing -- Ch 3: WGS for Bacterial Virulence Assessment -- Ch 4: Epidemiological Typing by WGS -- Ch 5: Bioinformatics Approaches for WGS Analysis -- Ch 6: WGS for Clinical Virology -- Ch 7: WGS for Clinical Mycology -- Ch 8: WGS for Clinical Parasitology -- Ch 9: Long Read Sequencing -- Ch 10: Aspects of WGS Integration -- Ch 11: Microbiome Analysis -- Ch 12: Metagenomics of Environmental Samples -- Ch 13: Clinical Metagenomics -- Ch 14: Metagenomics for Pathogen Discovery -- Ch 15: Advanced Applications for MALDI-TOF: Typing -- Ch 16: Advanced Applications for MALDI-TOF: Infectious Diseases and Antibiotic Susceptibility Testing (AST) -- Ch 17: Omics for Food and Water Microbiology -- Ch 18: Omics for Forensic and Post-Mortem Microbiology -- Ch 19: Omics for Antimicrobial Resistance Surveillance -- Ch 20: Total Laboratory Automation.
    Abstract: Various “omics” methods have recently revolutionized molecular diagnostics. Next-generation sequencing (NGS) makes it possible to sequence a human genome in just one day. Whole genome sequencing (WGS) greatly improves the ability to investigate the outbreaks of numerous pathogens. Metagenomics helps to analyze the microbiome, which aids greatly in identifying the pathogenesis of infectious diseases. Proteomic-based methods, namely matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF-MS), have a promising role in identifying myctobacteria and fungi, and predicting antimicrobial resistance. While there are numerous scientific publications on “omics” applications for microbiology, there are relatively few books that review this topic from a clinical diagnostics perspective. This book looks at this field from a holistic viewpoint, instead of limiting by type of “omics” technology, in order to cover the body of knowledge needed for practitioners and academics interested in clinical and public health microbiology. Additionally, it addresses the management, economical, regulatory and operational aspects of integrating these technologies into routine diagnostics.
    Type of Medium: Online Resource
    Pages: VI, 240 p. 17 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030621551
    DDC: 610.72
    Language: English
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biotechnology. ; Biomedical engineering. ; Biomedical Research. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Graviola Fruit Extraction by Ionic Liquid Microwave-assisted Extraction (IL-MAE) -- Role of Ionic Liquids in the Enzyme Stabilization: A Case Study with Trichoderma ressie Cellulase -- Role of Ionic Liquids in the Processing of Lignocellulosic Biomass -- Proliferation of rat amniotic stem cell (AFSC) on modified surface microcarrier -- Application of spectroscopic methods for the analysis of non-halal meats in food products: A narrative review -- Identification of Potential Biomarkers of Porcine Gelatin -- Gamma Ray Mutagenesis on Bacteria Isolated from Shrimp Farm Mud for Microbial Fuel Cell Enhancement and Degradation of Organic Waste -- Effect of temperature on antibacterial activity and fatty acid methyl esters of Carica papaya seed extract -- Solid-state Fermentation of Agro-industrial Waste Using Heterofermentative Lacti Acid Bacteria -- Synthesis of chitosan-folic acid nanoparticles as a drug delivery system for propolis compounds.
    Abstract: This contributed volume, “Multifaceted Protocols in Biotechnology, Volume 2”, consists of multidisciplinary methods and techniques commonly used in biotechnology studies. There are two sections covered in this book – Ionic Liquid Related Techniques & Evergreen Biotechnology Techniques. A brief introduction supports each protocol to allow easy learning and implementation. The first section consists of three chapters covering studies in modern biotechnology focusing on the role of ionic liquid techniques in extracting secondary metabolites, enzyme stabilization and biomass processing. The second section covers evergreen methodologies. It comprises five chapters covering topics on microcarrier technology for cell culture; Polymerase Chain Reaction for non-halal sources detection in food; ELISA for biomarker identification; gamma ray-induced mutagenesis for enhancing microbial fuel cells; and the effect of temperature on antibacterial activity of Carica papaya seed extract. This book will be useful to graduate students, researchers, academics, and industry practitioners working in the area of biotechnology.
    Type of Medium: Online Resource
    Pages: VII, 159 p. 45 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030755799
    DDC: 610.72
    Language: English
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  • 7
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Biomedical Research. ; Medical Genetics. ; Biomedical Research.
    Description / Table of Contents: Chapter 1. General Overview of the Origins and Pathology of Ovarian Cancer -- Chapter 2_An Introduction to the Current Management of Ovarian Cancer in the Era of Precision Oncology -- Chapter 3_The Hallmarks of Ovarian Cancer: Actionable Genetics, Targetable Pathways and Predictive Biomarkers -- Chapter 4_Genetic Alterations in Ovarian Cancer as Prognostic and Predictive Biomarkers of Therapy Response and Surgical Outcomes -- Chapter 5_The Emergence of Circulating Tumor DNA in the Management of Ovarian Cancer -- Chapter 6_Proteomic Biomarkers for Early Detection and Patients’ Stratification in Ovarian Cancer -- Chapter 7_Cutting-edge Technologies and Ovarian Cancer.
    Abstract: This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.
    Type of Medium: Online Resource
    Pages: XV, 229 p. 9 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811618734
    DDC: 610.72
    Language: English
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biophysics. ; Senses and sensation. ; Nanoscience. ; Biotechnology. ; Biomedical Research. ; Sensory Systems. ; Nanophysics. ; Chemical Bioengineering.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Bioreceptors -- Chapter 3. Catalytic Biosensors -- Chapter 4. Affinity Biosensors -- Chapter 5. Affinity Biosensors -- Chapter 6. Label-free Biosensors -- Chapter 7. Bioreceptor Immobilization -- Chapter 8. Biochips. Chapter 9. Genome Sequencing -- Chapter 10. Genome Sequencing -- Chapter 11. Micro Electrode Arrays, Implants and Organs-on-a-Chip -- Appendix.
    Abstract: This textbook describes the basic principles and mechanism of action of biosensor systems, and introduces readers to the various types of biosensors; from affinity biosensors to catalytic, optical and label-free biosensors, the most common systems are explained in detail. Dedicated advanced sections focus on biochips and genome sequencing methods as well as organs-on-a-chip. The textbook helps readers to understand the elementary components of biosensors, and to identify and illustrate each function in the biosensor information flow, from recognition to transduction and transmission. Furthermore, readers will receive guidance in critically analyzing published studies on biosensor research, helping them to develop appropriate concepts and independently propose their own solutions. The textbook is intended for master’s students in bioengineering, biophysics, biotechnology and pharmacology that need a solid grasp of biosensor system technologies and applications, as well as students in related medical technological fields.
    Type of Medium: Online Resource
    Pages: XVIII, 328 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030764692
    Series Statement: Learning Materials in Biosciences,
    DDC: 610.72
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Physiology. ; Internal medicine. ; Biomedical Research. ; Medical Genetics. ; Physiology. ; Internal Medicine.
    Description / Table of Contents: Basic structure, physiology and biochemistry of connective tissues and extracellular matrix collagens -- Tendon Extracellular Matrix Assembly, Maintenance and Dysregulation Throughout Life -- Basic Components of Connective Tissues and Extracellular Matrix: Fibronectin, Fibrinogen, Laminin, Elastin, Fibrillins, Fibulins, Matrilins, Tenascins and Thrombospondins -- Proteoglycans and Diseases of Soft Tissues -- Growth Factor Roles in Soft Tissue Physiology and Pathophysiology -- Connective Tissue Disorders and Cardiovascular Complications: The Indomitable Role of Transforming Growth Factor-β Signaling -- The Pathophysiology and Pathogenesis of Marfan Syndrome -- Ehlers-Danlos syndromes, joint hypermobility and hypermobility spectrum disorders -- Ehlers–Danlos Syndrome Associated with Glycosaminoglycan Abnormalities -- Loeys-Dietz Syndrome -- Meester-Loeys syndrome -- Clinical and Molecular Delineation of Cutis Laxa Syndromes: Paradigms for Elastic Fiber Homeostasis -- Collagen VI Muscle Disorders: Mutation Types, Pathogenic Mechanisms and Approaches to Therapy -- Connective Tissue Disorders in Domestic Animals.
    Abstract: This volume represents a substantially revised and updated 2nd edition of a reference handbook on major structural components of soft connective tissues and a whole slew of heritable diseases of soft connective tissues. The number of clearly identifiable and distinct disorders has grown somewhat since the 1st edition in 2014, e.g., Ehlers-Danlos syndrome has now 13 entities. A brand new syndrome, Meester Loeys syndrome carrying the name of Bart Loeys was added as a companion to Loeys-Dietz syndrome. Numerous variations of cutis laxa and joint mobility disorders have been discovered taking advantage of recent advancements in genetic analysis. We have acquired better understanding of pathogenesis and biochemical changes in some other, more established entities, such as Marfan and collagen VI myopathies where better management and possible treatment are on the horizon. Even in the case of connective tissue diseases in domestic animals some progress has been made. All these updates were contributed by a group of distinguished and preeminent physicians and scientists, all of them not just working in the field but making new discoveries described by them. Readers will notice that seemingly there is an overlap among many of these disorders. And indeed, many of them, if not most are interconnected because of the prominent roles of TGFβ, of fibrillin microfibrils and collagen fibril assembly (and other molecules) playing in connective tissues physiology, and by extension in pathogenesis of many disorders described in the book. What I found particularly helpful that author(s) of each chapter bring their own perspective even when described closely related mechanism of the disease. These observations should help with diagnosis and management of such cases. The first chapters are more general, concentrating more on the physiology, structure and biochemistry of normal soft tissues. That should help in better understanding of the pathophysiology. Last but not least, the chapters are very readable, more like detective stories than dry description of genetic/biochemical defects. I do hope that basic scientists and clinicians with similar and diverse interests alike will appreciate this volume and will be inspired by it to develop their research in the field.
    Type of Medium: Online Resource
    Pages: IX, 343 p. 1 illus. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030806149
    Series Statement: Advances in Experimental Medicine and Biology, 1348
    DDC: 610.72
    Language: English
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  • 10
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Public health. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology. ; Public Health.
    Description / Table of Contents: Clinical features, diagnostic evaluation and management of COVID-19 patients -- Outbreak of COVID-19: A Detailed Overview and Its Consequences -- A paradigm gap in host-pathogen interaction studies: Lesson from the COVID-19 pandemic -- SARS/CoV-2: Behavioral Host Manipulation -- Management of COVID-19 in the Intensive Care Unit -- First wave of Covid-19 pandemic in Italy: data and evidence -- Risk factors for COVID-19: diabetes, hypertension and obesity -- Current challenges for the effective management of the COVID-19 pandemic -- COVID-19 Outbreak Challenges in Indian Migrant Pregnant and Lactating Mothers: Learnt Lesson Demands Phronesis and Hierarchical Strategies for Such Future Pandemics -- COVID-19 and Extracorporeal Membrane Oxygenation -- COVID-19's Clinical-Pathological Evidence in Relation to its Repercussion on the Central and Peripheral Nervous System -- Anatomopathological Aspects and Clinical Correlation of COVID-19: A Systematic Review -- SARS-CoV-2 liability: the hidden mystery behind its presentation in children.
    Abstract: The book Coronavirus Therapeutics Volume II provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 241 p. 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851132
    Series Statement: Advances in Experimental Medicine and Biology, 1353
    DDC: 610.72
    Language: English
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  • 11
    Keywords: Medicine Research. ; Biology Research. ; Virology. ; Clinical medicine Research. ; Epidemiology. ; Biomedical Research. ; Virology. ; Clinical Research. ; Epidemiology.
    Description / Table of Contents: Origin and structural biology of Novel Coronavirus (SARS-CoV-2) -- The Molecular Virology of Coronaviruses with Special Reference to SARS-CoV-2 -- Epidemiology, transmission and molecular immunopathology of SARS-CoV-2 -- Epidemiology and Etiopathogeny of Covid-19 -- Immunological and Hematological Response in COVID-19 -- Toll-like receptors (TLRs) as Therapeutic Targets for Treating SARS-CoV-2: An Immunobiological Perspective -- Potential drug strategies to target Coronaviruses -- Possible therapeutic intervention strategies for COVID-19 by manipulating the cellular proteostasis network -- The potential impact of statins in the treatment of patients with COVID-19 infection -- Anticoronavirus activity of water-soluble pristine C60 fullerenes: in vitro and in silico screening -- Application of Nanoscale materials and nanotechnology against viral infection: A special focus on Coronaviruses -- Obesity: A Risk Factor for Covid-19 -- Cytokine Storm and Failed Resolution in COVID-19: Taking Cue from Multiple Sclerosis.
    Abstract: The book Coronavirus Therapeutics Volume I provides the most comprehensive review on contemporary knowledge on the origin, structural biology and molecular aspects of Coronaviruses. It also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 222 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030851095
    Series Statement: Advances in Experimental Medicine and Biology, 1352
    DDC: 610.72
    Language: English
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  • 12
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Proteins . ; Cytology. ; Biomedical Research. ; Protein Biochemistry. ; Cell Biology.
    Description / Table of Contents: Inter-Relationship Between the Inflammation and Heat Shock Protein in Cancer Development: A Possible Target for Diagnosis and Cancer Immunotherapy -- Chaperonin Hsp60 and Cancer Therapies -- Combined Thermotherapy and Heat Shock Protein Modulation for Tumor Treatment -- Small Molecule Inhibitors Targeting Heat Shock Response Pathways: Lessons from Clinical and Preclinical Studies in Cancer Therapeutics -- Multifaceted Roles of Heat Shock Factor 1 (HSF1) in Cancer -- Exploring the Role of Heat Shock Proteins in the Development of Gastric Cancer -- Heat Shock Proteins in Atrial Fibrillation -- Threading Microarrays into Novel Applications -- Regulation of Kaposi’s Sarcoma-associated Herpesvirus Biology by Host Molecular Chaperones -- Role of Heat Shock Factors in Diseases and Immunity -- Heat Shock Proteins and Pain -- Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway -- Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with diverse Cellular and Molecular Functions -- Roles of Heat Shock Proteins on Antigen Presentation -- Heat shock proteins mediate anastasis and plasticity of thermotolerant cells.
    Abstract: The book Heat Shock Proteins in Human Diseases provides the most comprehensive review on contemporary knowledge on the role of heat shock proteins (HSP) in various types of human diseases including cancer, cardiovascular disease, microbiology and inflammation. These diseases were specifically chosen due to their dismal prognosis, the survival benefit offered by the current standards do not greatly impact the overall survival statistics with the disease and are associated with toxicity. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in human diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed articles that review present research activity on the role of heat shock proteins in human diseases and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Cardiovascular Diseases, Microbiology, Inflammation, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
    Type of Medium: Online Resource
    Pages: IX, 297 p. 31 illus., 27 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030622893
    Series Statement: Heat Shock Proteins, 21
    DDC: 610.72
    Language: English
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  • 13
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Drug delivery systems. ; Regenerative medicine. ; Biomedical Research. ; Pharmacology. ; Drug Delivery. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers -- Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications -- Metal-organic Framework—Polymer Mixed-Matrix Membranes -- Insights into Adaptive Selforganized Supramolecular Structures from Molecular Modeling and Visualization -- Self-Assembled Metallacages as Drug Delivery Systems: Design Concepts and Challenge -- Functional Microporous Polymer Networks: Synthesis and Applications -- A Story on Carbon Dioxide and its Hydration -- Inverse Design and Hierarchical Multiscale Modelling of Biological Matter -- DNA-Directed Self-assembly of Macromolecular Structures -- Luminescent Complexes and their Assemblies : from Understanding to Artificial Virus -- Tailor-Made Polymers and Nanoparticles for Applications in Nanomedicine -- Squalene-based Nanomedicines : An Original and Efficient Approach for the Treatment of Neurological Disorders without Crossing the Blood-Brain Barrier -- Biodegradable Nanoparticles for Specific Drug Transport -- Multivalent rotaxanes designed as antibiofilm agents -- Measuring Ionic Transport through Lipid Bilayers -- Polymeric Carriers for Transporting Nucleic Acids - Contributions to the Field -- Smart Polymeric Materials for Drug Delivery -- Supramolecular Guanosine-quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications -- Hydrogelation of Chitosan with Monoaldehydes towards Biomaterials with Tuned Properties -- Inorganic Nanoarticles as Free Radical Scavengers -- A Microbiological Epilogue - Nosocomial Infections -- Molecular Dynamic Simulations and In Silico Analysis of Supramolecular Self-Assembled Structures -- Validation of the Non Toxicity of Non Viral Genetic -- Kinetics Transport of Ions/Water Through Nano-Scale Channels : Review And Update.
    Abstract: This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations. The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.
    Type of Medium: Online Resource
    Pages: XII, 371 p. 174 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030574567
    DDC: 610.72
    Language: English
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  • 14
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Artificial intelligence. ; Bioinformatics. ; Biomedical Research. ; Artificial Intelligence. ; Bioinformatics.
    Description / Table of Contents: 1-Dimensional Convolution Neural Network Classification Technique for Gene Expression Data -- Classification of Sequences with Deep Artificial Neural Networks: Representation and Architectural Issues -- A Deep Learning Model for MicroRNA-Target Binding -- Recurrent Neural Networks Architectures for Accidental Fall Detection on Wearable Embedded Devices -- Medical Image Retrieval System using Deep Learning Techniques -- Medical Image Fusion using Deep Learning -- Deep Learning for Histopathological Image Analysis -- Innovative Deep Learning Approach for Biomedical Data Instantiation and Visualization -- Convolutional Neural Networks in Advanced Biomedical Imaging Applications -- Deep Learning for Lung Disease Detection from Chest X-Rays Images -- Deep Learning in Multi-Omics Data Integration in Cancer Diagnostic -- Using Deep Learning with Canadian Primary Care Data for Disease Diagnosis -- Brain Tumor Segmentation and Surveillance with Deep Artificial Neural Networks.
    Abstract: This book is the first overview on Deep Learning (DL) for biomedical data analysis. It surveys the most recent techniques and approaches in this field, with both a broad coverage and enough depth to be of practical use to working professionals. This book offers enough fundamental and technical information on these techniques, approaches and the related problems without overcrowding the reader's head. It presents the results of the latest investigations in the field of DL for biomedical data analysis. The techniques and approaches presented in this book deal with the most important and/or the newest topics encountered in this field. They combine fundamental theory of Artificial Intelligence (AI), Machine Learning (ML) and DL with practical applications in Biology and Medicine. Certainly, the list of topics covered in this book is not exhaustive but these topics will shed light on the implications of the presented techniques and approaches on other topics in biomedical data analysis. The book finds a balance between theoretical and practical coverage of a wide range of issues in the field of biomedical data analysis, thanks to DL. The few published books on DL for biomedical data analysis either focus on specific topics or lack technical depth. The chapters presented in this book were selected for quality and relevance. The book also presents experiments that provide qualitative and quantitative overviews in the field of biomedical data analysis. The reader will require some familiarity with AI, ML and DL and will learn about techniques and approaches that deal with the most important and/or the newest topics encountered in the field of DL for biomedical data analysis. He/she will discover both the fundamentals behind DL techniques and approaches, and their applications on biomedical data. This book can also serve as a reference book for graduate courses in Bioinformatics, AI, ML and DL. The book aims not only at professional researchers and practitioners but also graduate students, senior undergraduate students and young researchers. This book will certainly show the way to new techniques and approaches to make new discoveries.
    Type of Medium: Online Resource
    Pages: VI, 359 p. 130 illus., 40 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030716769
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Urology. ; Reproductive health. ; Biomedical Research. ; Urology. ; Reproductive Medicine.
    Description / Table of Contents: Section I – Introduction to Spermatology Symposium -- Chapter 1. The XIIIth International Symposium on Spermatology -- Chapter 2. Fifty Years of the Spermatology Symposium -- Chapter 3. Spermatology in Sweden -- Section II – Are Sperm at the Verge of Extinction? -- Chapter 4. Temporal trends in human sperm counts: Findings and implications -- `Chapter 5. Is Decreasing Sperm Concentrations a Sign of a General Decay in Fertility Potential? -- Chapter 6. Environmental toxicants and sperm production in men and animals -- Section III – Sperm DNA – protection and delivery of a complete and undamaged genome? -- Chapter 7. Post-testicular sperm DNA oxidation: what to be afraid of? -- Chapter 8. Sperm as a possible source of transgenerational epimutations and genetic instability -- Chapter 9. Complex population of chromatin-associated proteins identified in mature sperm of the European sea bass (Dicentrarchuslabrax) through high-throughput proteomic analysis -- Chapter 10. Does Cinnamtannin B-1 protects or destabilize sperm DNA? Contradictory results of SCSA® and TUNEL Invited presentations -- Chapter 11. Peripubertal serum dioxin concentrations and sperm methylome of young Russian adults -- Chapter 12. Sperm DNA fragmentation in human split ejaculates -- Section IV - Sperm Competition, Evolution and Sperm-Egg Interaction -- Chapter 13. The sexual cascade: evolutionary dynamics of sperm competition -- Chapter 14. Genotype-phenotype associations in relation to evolution of sperm form and function -- Chapter 15. From mouse to human: New aspects of sperm transport and fertilization using cutting edge technologies -- Chapter 16. First Snapshot of How Sperm Binds the Egg at the Molecular Level -- Chapter 17. The Typical and Atypical Centrioles and Their Potential Roles in the Sperm and Embryo -- Chapter 18. Adaptive modifications of the regulation of sperm motility in the diversification of reproductive modes of amphibians -- Section V - Genetic aspects of sperm production and performance and its effects on the offspring -- Chapter 19. When cilia go bad - the complex genetics of ciliopathies -- Chapter 20. Within-Ejaculate Sperm Selection and its Implications for Assisted Reproduction Technologies -- Chapter 21. Requirements for informative and robust computational measures of sperm motility -- Chapter 22. Effect of cryopreservation on the genome of sperm in animal and humans -- Chapter 23. Mutations in the CFAP-coding Genes Lead to Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella -- Chapter 24. The mouse-specific Gly-to-Cys mutation in mammalian acrosin is a cause of impairment in proteolytic activity -- Chapter 25. Chemical and genetic approaches to identify C. elegans spermiogenesis-related factors -- Section V -CASA - Advances and Challenges -- Chapter 26. CASA in the clinical andrology laboratory -- Chapter 27. Process and Data Management of Casa in Animal Spermatozoa -- Chapter 28. Relationship between flagellar movement and head trajectory at higher frame rates-is this still a valid approach for CASA? -- Chapter 29. CASA a Suitable tool for epidemiology and reprotox studies -- Section VI -Challenges for Sperm Function In Vitro -- Chapter 30. Common challenges for sperm in vitro- causes and consequences -- Chapter 31. Main effects of in vitro manipulation of spermatozoa -- Chapter 32. Effect of Melatonin on Capacitation and Ca2+ Distribution in Red Deer Spermatozoa -- Chapter 33. Unravelling the signal transduction pathways of novel mitochondrial peroxiporins in activated piscine spermatozoa -- Chapter 34. Prolonged chilled preservation and preliminary investigations of energy production of koala (Phascolarctos cinereus) spermatozoa -- Chapter 35. Sperm motion and metabolism in physiological conditions -- Chapter 36. Gametes collision in fresh water fish: evidences of guidance and selection -- Chapter 37. Lectin-binding pattern changes on the bovine sperm after differently induced process of capacitation -- Section VII -Heterogeneity of Sperm Morphology and Laboratory Techniques to Overcome Assessment Challenges -- Chapter 38. Have we conquered sperm morphology analysis in different mammalian species as analysed by CASMA? -- Chapter 39. Progress with sperm morphology evaluation after the strict criteria prognosis groups era due to the introduction of the new lower reference limit values for semen parameters of the 2010 WHO manual -- Chapter 40. A structured assessment for the assessment of human sperm morphology -- Chapter 41. On the Indispensability for Standardization of the Basic Examination of Human Semen -- Chapter 42. A simple but dramatic technical improvement in the Diff Quik stain protocol used for preparing specimens for sperm morphology evaluation (Improved Diff Quik stain protocol for preparation of sperm morphology evaluation specimens) -- Section VII - Fertility and Infertility -- Chapter 43. Intracellular Viruses Identification in Sperm Assay of Patients with Fertility problems -- Chapter 44. Association between vitamin D intake and vitamin D status with semen parameters among young men in Southern Spain -- Chapter 45. Single cell analysis of intracellular calcium signalling of patient sperm and its relation to IVF success -- Chapter 46. Sperm from a patient with a homozygous in-frame deletion in CATSPERE lack functional CatSper expression and fail to fertilise at IVF -- Chapter 47. Changes in pattern of protein phosphorylation in bull testicular and epididymal sperm -- Chapter 48. Proteomics and biomarker identification in improved sperm motility parameters after 4 h of ejaculatory abstinence -- Chapter 49. HSP90A may control spermatogenesis of Asian elephant (Elephas maximus) cryptorchid testes -- Chapter 50. Improved sperm function in human sperm subpopulations: a model for studying subfertility -- Chapter 51. Absence of BSP protein have not important effect on male infertility. .
    Abstract: This Symposium had 7 main themes with invited speakers, 17 free oral presentations and 44 poster presentations. Morning sessions were separated from afternoon sessions by a two-hour lunch break to inspire to spontaneous interaction between participants. The long, bright evenings of early May with a generous weather also contributed to the intended atmosphere of scientific and social interchange. Themes Are Sperm at the Verge of Extinction? Sperm DNA – protection and deliv­ery of a complete and undamaged genome Sperm Competition, Evolution and Sperm-Egg Interaction Genetic aspects of sperm production and performance and its effects on the offspring CASA - Advances and Challenges Challenges for Sperm Function In Vitro Heterogeneity of Sperm Morphology and Laboratory Techniques to Overcome Assessment Challenges Sperm Motility (Free Poster Theme) Fertility and Infertility (Free Poster Theme).
    Type of Medium: Online Resource
    Pages: X, 370 p. 72 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030662929
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Respiratory organs Diseases. ; Respiratory organs. ; Physiology. ; Immunology. ; Inflammation. ; Biomedical Research. ; Pneumology. ; Respiratory Physiology. ; Immunology. ; Inflammation.
    Description / Table of Contents: Overload of Medical Documentation: A Disincentive for Healthcare Professionals -- Epidemiologic Benefits of Pneumococcal Vaccine Introduction into Preventive Vaccination Programs -- Serum Vitamin D and Immunogenicity of Influenza Vaccination in the Elderly -- Influenza A (H1N1) and Respiratory Syncytial Virus (RSV) Coinfection in a Newborn Child: A Case Report -- Thoracic Manifestation of Granulomatosis with Polyangiitis: A Case Report -- The Natural Course of Impaired Fasting Glucose -- Oleosins: A Short Allergy Review -- Shortage of Physicians: A Critical Review -- Fluid Therapy in Patients Undergoing Abdominal Surgery: A Bumpy Road Towards Individualized Management -- Manual Pressure Release and Low-Grade Electrical Peripheral Receptor Stimulation in Nonspecific Low Back Pain: A Randomized Controlled Trial -- Human Inhalation Study with Zinc Oxide: Analysis of Zinc Levels and Biomarkers in Exhaled Breath Condensate. Cognitive Function After Lung Transplantation.
    Abstract: This volume is dedicated to multidisciplinary research at the interface between basic biomedicine and clinical practice. This book guides best practice in the diagnosis and therapy while dealing with difficult-to-treat disorders of yet unclear etiology. Chapters address such disorders as granulomatosis with polyangiitis causing autoimmune-related multiorgan inflammation of blood vessels, increasingly widespread allergy to peanuts, occupational exposure to zinc oxide, and immunogenic responses to pneumococcal and influenza vaccination underlying their preventive effectiveness. Other hot issues deal with the proper use of fluid therapy in the perioperative period and a cognitive decline in lung transplant patients. A new physiotherapeutic approach of treating key myofascial trigger points in low-back pain appears highly beneficial in reducing patients’ disability, advancing physiotherapy of this overwhelming condition. Finally, other chapters consider ways to streamline medical management to increase the number of physicians and their availability for patients, a particularly sensitive issue in the current COVID-19 pandemic. The dissemination of clinical knowledge about high-risk and hardly controllable conditions is an inalienable part of progress in medical practice. The book is a resource for clinical specialists, general practitioners, and allied healthcare professionals.
    Type of Medium: Online Resource
    Pages: VI, 101 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030702069
    Series Statement: Clinical and Experimental Biomedicine, 1324
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Physiology. ; Life sciences. ; Pharmacology. ; Biomedical Research. ; Physiology. ; Life Sciences. ; Pharmacology.
    Description / Table of Contents: Introduction -- Metabolism of endogenous H2S and its metabolites -- A common molecular switch for H2S to regulate multiple protein targets -- The protective role of H2S in the heart -- The proangiogenic effects of H2S -- H2S and the immune system -- Protection of H2S on the neurons -- The role of H2S in the metabolism of glucose and lipids -- Regulation of the ion channels by H2S -- The epigenetic mechanisms for H2S signalling -- The development of H2S donor.
    Abstract: Hydrogen sulfide (H2S) has emerged as an important gas signalling molecule in a series of organs/tissues, on the diseases of which it plays protective roles, such as proangiogenic effects in ischemic tissues, antiapoptotic effects in the cardiomyocytes, regularization of fatal arrhythmia in myocardial infarction, amelioration of inflammation in autoimmune diseases, modification of neuronal transmission, increase in sodium excretion from the kidney, and amelioration of insulin resistance, etc. This book focuses on the effect of hydrogen sulfide in cardiovascular system, immune system, nervous system, kidney, as well as on the metabolism of glucose and lipids and regulation of ion channels and so on. This book also provides the advances in the understanding of endogenous H2S metabolism and H2S protein targets, as well as H2S donors. It will benefit researchers in both academics and industry working on the underlying mechanism of H2S field and the future of translational medicine of H2S.
    Type of Medium: Online Resource
    Pages: IX, 236 p. 47 illus., 39 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811609916
    Series Statement: Advances in Experimental Medicine and Biology, 1315
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Pharmacology. ; Biomedical Research. ; Cell Biology. ; Pharmacology.
    Description / Table of Contents: Oxidative stress and anti-oxidant strategies in human diseases -- Oxidative stress in the tumorimmune microenvironment -- Oxidative stress-mediated stem cell aging -- Stress proteins: Biological functions, human diseases and virus infections -- Importance of mitochondrial quality controls in Parkinson’s disease: the potential interplay of mitochondrial unfolded protein response and mitophagy -- Autophagy in cellular stress responses -- Cysteine metabolism in cancer progression and therapy resistance -- Stress and circadians -- ROS, glucose and lipid metabolism -- Drug repurposing: An avenue towards stress medicine in cancer therapy -- Redox regulation of metabolic enzymes in cancer -- Stress and inflammation -- Oxidative stress in cell signaling and cell fate determination under glucose starvation.
    Abstract: This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.
    Type of Medium: Online Resource
    Pages: VI, 323 p. 43 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811605222
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical genetics. ; Cytology. ; Lipids. ; Biomedical Research. ; Medical Genetics. ; Cell Biology. ; Cell Biology. ; Lipidology.
    Description / Table of Contents: Foreword -- Ferroptosis: Concepts and Definitions -- Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT inhibitors -- Iron Homeostasis and Metabolism: Two Sides of a Coin -- The Role of NCOA4-mediated Ferritinophagy in Ferroptosis -- Emerging Role for Ferroptosis in Infectious Diseases -- Small Molecule Regulators of Ferroptosis -- Necroptosis, The other main Caspase-Independent Cell Death.
    Abstract: This book focuses on the emerging role of ferroptosis in human diseases. It gives a detailed perspective on how to induce or suppress ferroptosis to treat challenging conditions such as infectious diseases, including COVID-19, tuberculosis, parasitic diseases and cancer. The book serves as a practical guide by providing a valuable collection of all currently known activators or inhibitors of ferroptosis. It will enable readers to choose molecules for experimental design for in vitro and in vivo studies of ferroptosis. Furthermore, this volume highlights the aspects of iron metabolism and its connection to ferritinophagy, a ferritin selective autophagy, with profound implications in neurodegenerative diseases such as Alzheimer, Parkinson, Huntington and ALS. Lastly, it describes necroptosis, another important form of cell death, along with its connections to human disorders and potential crosstalk with ferroptosis. While covering basic concepts, the book delves into mechanisms and modulation of ferroptosis for treating a wide variety of human diseases thus offering a valuable and informative resource for both, scientists and clinical researchers.
    Type of Medium: Online Resource
    Pages: IX, 140 p. 37 illus., 33 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030620264
    Series Statement: Advances in Experimental Medicine and Biology, 1301
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Neurosciences. ; Biomedical Research. ; Neuroscience.
    Description / Table of Contents: Constituents of Cannabis Sativa -- Synthetic and Natural Derivatives of Cannabidiol -- Clinical Pharmacokinetics of Cannabinoids and Potential Drug-Drug Interactions -- Cannabinoid Receptors and Ligands: Lessions from CNS Disorders and the Quest for Novel Treatment Venues -- Sleep-Wake Neurobiology -- Cannabinoids and Sleep/Wake Control -- Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals -- Modulation of Noradrenergic and Serotonergic Systems by Cannabinoids: Electrophysiological, Neurochemical and Behavioral Evidence -- Natural Cannabinoids as Templates for Sleep Disturbances Treatment -- The Effect of Cannabinoids on the Brain´s Circadian Clock -- Effects of Cannabis Consumption on Sleep -- Addiction and Sleep Disorders -- Cannabis for Restless Legs Syndrome.
    Abstract: Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome. The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.
    Type of Medium: Online Resource
    Pages: XXII, 183 p. 37 illus., 21 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030616632
    Series Statement: Advances in Experimental Medicine and Biology, 1297
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Arts. ; Artificial intelligence. ; Knowledge, Theory of. ; Biomedical Research. ; Arts. ; Artificial Intelligence. ; Epistemology.
    Description / Table of Contents: Introduction on Integrated Science: Science without Borders -- The Human Person as an Integrated System -- On the Nature of Qualitative Research in Process Transformations: The Changing Man in the Changing World.-Integrated Science: Ambitions, Practicalities, Misunderstandings -- The Integration of the Sciences and Integral Human Knowledge -- The Indelible Stamp of Lowly Origins: An Epistemic Architecture between the Sciences and Humanities -- Transdisciplinary Science: Integration or Systematic, Strategic and Catalytic Knowledge -- Models and Integration -- Unlaws: the Missing “Dark Matter” in the Philosophy of Science -- Life - Stabilization of the Unstable through Controlling Influence of Quantum Information -- The Sustainable Humanist Concept in Art and Science Synergies -- From Being One to Being Many. Understanding the Diversity of Bio‐Life: Human, Nonhuman and Liminal Beings in the in Bio Art and Body Art -- Composite Bodies in Times of Catastrophe. On Socio‐Material Assemblies, Affective Contagions and the Biodegradable -- Life, Complexity, Communication: Integrating Social Systems Theory and Consciousness -- Rethinking the Reverse Side of Artificial Intelligence -- The Question of Transdisciplinarity between Modern Science and Critical Thought -- Adaptive Networks at the Crossroad of Artificial Intelligence and Formal, Biological, Medical and Social Sciences -- Are We Ready for "Them" Now? The Relationship between Human and Humanoid Robots -- Integrating Computer Simulation and Social Theory for Planning and Managing Complex Problems -- Rethinking Managerial Control in the Contemporary Context -- Innovation and Altruism: A New Paradigm Defining the Survival of Corporations -- Integrated Science 2050: Science without Borders.
    Abstract: The INTEGRATED SCIENCE Book series aims to publish the results of the most updated ideas and reviews in transdisciplinarity fields, to highlight the integration of different disciplines, including formal sciences, physical-chemical sciences, engineering, biological sciences, medical sciences, and social sciences. The whole world is suffering from complex problems; these are borderless problems; so, a borderless solution could be the solution for such complex problems. The “INTEGRATED SCIENCE: Science without Borders” is the first volume of the INTEGRATED SCIENCE Book series. It focuses on the human as an integrated system and finding solutions for the problems facing humanity. For its purpose, it introduces a kind of science, which is called integrated science and portrays results from every effort trying to integrate separate subjects. Integration of science with integral human knowledge, ancient science with modern science, and quantity with quality are a few examples of such efforts. Some difficulty might, however, lie in integrating knowledge systems. In this edited book, art and artificial intelligence reveal to us their different methods of work to overcome ambitions and become applicable to the world system full of unpredictable challenges. Art offers a lens to see the beauty of infinite complexity. The resultant artistic background would permit the perfect programming and bioengineering of biological systems, which we could never do by direct eye viewing. Networking is the spot where the crossing of formal, biological, medical, and social sciences with artificial intelligence takes place. By working within a network, individual thinking to the old unresolved problems reduces to simulation and bioengineering, a relatively effortless route for innovation, creativity, and altruism. In this manner, it would be understandable that there is an obvious way to speed up the growth of science – that is, moving on the edge of the intersection between knowledge-based systems. The INTEGRATED SCIENCE Book series is to provide an overview of the essential elements of integrated science. The unique aspect of this series, privileging it from other books, is covering all aspects of science as a true one nature.
    Type of Medium: Online Resource
    Pages: XVIII, 495 p. 112 illus., 97 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030652739
    Series Statement: Integrated Science, 1
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Immunology. ; Cytology. ; Biomedical Research. ; Human Physiology. ; Immunology. ; Cell Biology.
    Description / Table of Contents: Chapter 1 General Thinking About Inflammation -- Chapter 2 Inflammation from the Standpoint of Leukocytes -- Chapter 3 Vessels and Coagulation -- Chapter 4 Sterile Inflammation -- Chapter 5 Issue of Self and Non-self -- Chapter 6 Extension of Endogenous Field -- Chapter 7 Evidence for Existence of Endogenous TLR4 Ligands -- Chapter 8 Autoinflammatory Disorders -- Chapter 9 Cancer in General -- Chapter 10 Basic Research -- Chapter 11 Tumor Microenvironment -- Chapter 12 Whole-Body Matter -- Chapter 13 Premetastatic Microenvironment -- Chapter 14 What Is Homeostasis? -- Chapter 15 Explanation of Metastasis by Homeostatic Inflammation -- Chapter 16 Therapeutic Potential.
    Abstract: This book, now in a thoroughly revised and updated second edition, provides the latest information on cancer metastasis from the perspective of inflammation and presents new ideas on the complicated mechanisms of metastasis and potential therapeutic targets. Key features include discussion of mechanisms recently identified to be involved in the resolution phase of inflammation, presentation of the latest evidence regarding the roles of endogenous TLR4 ligands in metastasis, and thorough explanation of the concept of homeostatic inflammation and current understanding of the significance of its dysregulation for metastasis. Structure-based thinking is another important element of the book, and it is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, at the center of which cancer is located. Examples of the many additional specific topics covered in this edition include the functional involvement of new types of RNA in cancer, the insights offered by recent advances in bioinformatics, and the potential of a casein kinase 1α inhibitor in the treatment of acute myeloid leukemia. The book will be a valuable update and resource for both experienced and younger researchers. Homeostasis, originated from an idea of internal milieu by Claude Bernard, is eventually maintained by endogenous elements. The essential features of inflammation are leukocyte mobilization and increased vascular permeability, which could take place in many homeostatic or physiological conditions at low levels. Homeostatic inflammation is a concept to explain pathological settings such as metastasis in which irrespective of its level those inflammatory features are misused with endogenous molecules (see Chap. 14,15). As inflammation comprises many biological fields, targeting a single molecule for a disease could potentially make a therapeutic contribution to other diseases. For example, one focus is applied here to the roles of calprotectin in lung metastasis, which is implicated in psychiatric disorders and COVID-19 as shown by recent evidence.
    Type of Medium: Online Resource
    Pages: XX, 518 p. 81 illus., 33 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9789811617577
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Vocational guidance. ; School management and organization. ; School administration. ; Career education. ; Biomedical Research. ; Career Counseling. ; Organization and Leadership. ; Career Skills.
    Description / Table of Contents: Chapter 1: “Carving Your Own Path” – shaping your scientific identity -- Chapter 2: The Two Cornerstones of Academic Research: Writing Grant Applications and Publications -- Chapter 3: Setting up a Successful Research Group -- Chapter 4: Leading Your Research Group as a Principal Investigator -- Chapter 5: The Daily Work of Principal Investigators -- Chapter 6: Dealing with Failure and Stress in Academic Research -- Chapter 7: Thoughts of Principal Investigators about Work, Science, and Themselves -- Chapter 8: Under the Hood – Common Thinking Patterns of Principal Investigators -- Chapter 9: Epilogue -- Chapter 10: Methods.
    Abstract: Pursuing a career in biomedical research can be daunting, considering the stiffer competition and uncertain career prospects in academia. This book summarizes career advice gathered during in-depth interviews with 106 biomedical scientists who lead their own laboratories. The participating principal investigators are from 44 research institutions in 11 countries. This book is unique in that it provides a glimpse into the mindset of principal investigators. Here, the reader will learn about common thought patterns and values, as well as the range of opinions and ways of thinking to be found among a large group of active principal investigators – without having to read more than a hundred individual autobiographies. The book will benefit all PhD students who want to learn more about their supervisor’s mindset in order to successfully complete their projects. It can help freshly graduated PhDs planning to pursue an academic career, and MDs contemplating a career in research, to decide whether they truly want to embark on this path. Lastly, it can offer young principal investigators a source of inspiration on how to succeed and achieve their goals.
    Type of Medium: Online Resource
    Pages: XIX, 209 p. 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030855710
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Internal medicine. ; Biomedical Research. ; Internal Medicine.
    Description / Table of Contents: Introduction. --Part 1 -- Chapter 1. Role of Par-4 in lung cancer -- Chapter 2. Prostate apoptosis response-4 in nasopharyngeal carcinoma -- Chapter 3. Role of Par-4 in Chemoresistance and targeted therapies in ovarian and endometrial cancers -- Chapter 4. Regulation of Par-4 and role in GI tumors -- Chapter 5. Role of Par-4 in prostate cancer -- Chapter 6. Activation of apoptosis by Par-4 in pancreatic cancer -- Chapter 7. Role of Par-4 and GRP78 in Glioblastoma -- Chapter 8. Role of Par-4 in breast cancer recurrence -- Chapter 9. Involvement of Par-4 in breast cancer -- Chapter 10. Role of endogenous Par-4 in CLL -- Chapter 11. Role of Par-4 in inhibition of TCL1 induced growth -- Chapter 12. Par-4/THAP in survival of T-cell acute lympoblastic leukemia cells -- Chapter 13. Par-4 expression in cholangiocarcinoma -- Chapter 14. Par-4 suppresses breast cancer growth and invasion of breast cancer cells -- Chapter 15. PAWR as direct SRC-1/HOXC11 suppression target -- Chapter 16. Par-4 cleavage is required for TNF induced apoptosis -- Chapter 17. Par-4 secretagogues -- Chapter 18. Recombinant production and characterization of SAC -- Chapter 19. Anti-tumor effects of plant derived Par-4 -- Chapter 20. Par-4 in Mycobacterium tuberculosis Infected Macrophages -- Part 2 - Role in other Diseases -- Chapter 21. Role of Par-4 in ceramide inducible effects in neurons -- Chapter 22. Role of Par-4 in Alzheimers disease -- Chapter 23. Dopamine signaling in association with induction of Par-4 protein expression -- Chapter 24. Par-4 (PAWR) in major depressive disorder -- Chapter 25. Par-4 dependent apoptosis of islet β cells in type 2 diabetes -- Chapter 26. Par-4 in cardiac fibroblast senescence -- Chapter 27. Par-4 in ocular development and disease -- Chapter 28. Par-4 in apoptosis during human salivary gland development -- Chapter 29. Suppression of Par-4 protects human renal proximal tubule cells from apoptosis -- Chapter 30. Lessons from knockout mice -- Part 3 - From Bench to Bedside -- Chapter 31. Par-4 secretagogues in clinical trials -- Chapter 32. Potential of Par-4 as a therapeutic target for cancer.
    Abstract: Par-4 is a naturally occurring tumor suppressor. Studies have indicated that overexpression of Par-4 selectively induces apoptosis in cancer cells while leaving normal, health, cells unaffected. Mechanisms contributing to this cancer-selective action of Par-4 have been associated with PKA activation of intracellular Par-4 in cancer cells or GRP78 expression primarily on the surface of cancer cells. On the other hand, endogenous Par-4 sensitizes cells to the action of a broad range of apoptotic inducers acting via the extrinsic and intrinsic pathways. A number of binding partners of Par-4 have been identified and shown to regulate Par-4 function in cancer and other diseases, such as Alzheimer’s and major depression. Recent studies have recognized a number of natural products, dietary supplements, synthetic molecules and FDA-approved drugs that induce the secretion of Par-4 protein to cause apoptosis in primary or metastatic tumors, one of which is in clinical trials. More than 50 different laboratories worldwide are involved in Par-4 based research of this unique protein that has progressed from the bench to clinical trials. This second, companion volume will provide a comprehensive overview of Par-4’s role in cancer and other diseases. Chapters are written by leading researchers, and will be useful for a broad audience across the scientific community, particularly students and trainees, who are the next generation of scientists and clinicians to participate in new studies and discoveries on Par-4.
    Type of Medium: Online Resource
    Pages: X, 331 p. 121 illus., 93 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030805586
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Pharmacology. ; Human physiology. ; Internal medicine. ; Physiology. ; Biomedical Research. ; Medical Biochemistry. ; Pharmacology. ; Human Physiology. ; Internal Medicine. ; Physiology.
    Description / Table of Contents: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression -- Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening -- Ion channels in Lung Cancer -- Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer -- Transportome Malfunctions and the Hallmarks of Pancreatic Cancer -- How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer -- Ion Channels in Glioma Malignancy -- Membrane Transporters and Channels in Melanoma -- Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.
    Abstract: Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression Halima Ouadid-Ahidouch, Hamid Morjani, Julie Schnipper, Alban Girault, and Ahmed Ahidouch Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening Valerio Farfariello, Natalia Prevarskaya, and Dimitra Gkika Ion Channels in Lung Cancer Etmar Bulk, Luca Matteo Todesca, and Albrecht Schwab Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer Giuliano Ciarimboli, Gerit Theil, Joanna Bialek, and Bayram Edemir Transportome Malfunctions and the Hallmarks of Pancreatic Cancer Qi Ling and Holger Kalthoff How Dysregulated Ion Channels and Transporters Take a Hand in Esophageal, Liver, and Colorectal Cancer Christian Stock Ion Channels in Glioma Malignancy Luigi Catacuzzeno, Luigi Sforna, Vincenzo Esposito, Cristina Limatola, and Fabio Franciolini Membrane Transporters and Channels in Melanoma Ines Böhme, Roland Schönherr, Jürgen Eberle, and Anja Katrin Bosserhoff Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application Nagore Del-Río-Ibisate, Rocío Granda-Díaz, Juan P. Rodrigo, Sofía T. Menéndez, and Juana M. García-Pedrero.
    Type of Medium: Online Resource
    Pages: IX, 427 p. 50 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030909208
    Series Statement: Reviews of Physiology, Biochemistry and Pharmacology, 181
    DDC: 610.72
    Language: English
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  • 26
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Internal medicine. ; Biomedical Research. ; Medical Microbiology. ; Internal Medicine.
    Description / Table of Contents: 1. Inflammatory components of the thyroid cancer microenvironment - an avenue for identification of novel biomarkers -- 2. Disruption of Cell-Cell Communication in Anaplastic Thyroid Cancer as an Immunotherapeutic Opportunity -- 3. Exosomes in the Healthy and Malignant Bone Marrow Microenvironment -- 4. Structural Biology of the Tumor Microenvironment -- 5. Metabolic interactions between tumor and stromal cells in the Tumor Microenvironment -- 6. Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy -- 7. Non-coding RNAs in Papillary Thyroid Cancer: Interaction with cancer associated fibroblasts (CAFs) in the Tumor Microenvironment (TME) and regulators of differentiation and Lymph Node Metastasis.
    Abstract: Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor microenvironment's various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.
    Type of Medium: Online Resource
    Pages: XIII, 164 p. 19 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030832827
    Series Statement: Advances in Experimental Medicine and Biology, 1350
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Human physiology. ; Pharmacology. ; Nutrition   . ; Biomedical Research. ; Human Physiology. ; Pharmacology. ; Nutrition.
    Description / Table of Contents: 1 Introduction: Hot and Cold Theory, the Path Towards Personalized Medicine -- Part I Definitions and Beliefs -- 2 Principle of Hot and Cold and Its Clinical Application in Traditional Chinese Medicine -- 3 Principle of Hot and Cold and Its Clinical Application in Persian Medicine -- 4 Principle of Hot (Ushna) and Cold (Sheeta) and Its Clinical Application in Ayurvedic Medicine -- 5 Principle of Hot and Cold and Its Clinical Application in Latin American and Caribbean Medicines -- Part II Scientific Evidence -- 6 Hot and Cold Theory: Evidence in Nutrition -- 7 Hot and Cold Theory: Evidence in Pharmacology -- 8 Hot and Cold Theory: Evidence in Physiology -- 9 Hot and Cold Theory: Evidence in Systems Biology -- Part III Perspective -- 10 Hot and Cold Theory: A Personalized Medicine Approach -- 11 Hot and Cold Theory: Future Perspective.
    Abstract: This book is about the theory of Hot and Cold, a mutual fundamental base of traditional medicines all around the world. The theory describes the dynamic balance state of the body on the axis of hot and cold for each individual and proposes the fact that deviation from this equilibrium is a predisposing factor for diseases. Such an approach helps practitioners to provide treatments tailored to the patient’s condition, not the disease. This book, for the first time, has gathered native descriptions of Hot and Cold theory in different traditional medicines, including traditional Chinese medicine, Persian (Humoral, Unani) medicine, Ayurvedic medicine and Latin American and Caribbean medicines. After defining the common ground, contemporary research - in nutrition, pharmacology, physiology and systems biology - has been explored using scientific methodology. This work is the result of an international collaboration of more than 30 scientists and scholars with high reputations in their fields. Hot and Cold theory, as a holistic individualized approach in prevention, diagnosis and treatment, can be merged into the novel fast-paced concepts in systems biology and precision medicine. Through this bridge, the authors propose that the Hot and Cold theory should be revisited more deeply by medical scientists, who are the main audience of this book, to pave the way towards integrated holistic personalized medicine.
    Type of Medium: Online Resource
    Pages: XXIII, 174 p. 16 illus., 14 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030809836
    Series Statement: Advances in Experimental Medicine and Biology, 1343
    DDC: 610.72
    Language: English
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  • 28
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Biology Technique. ; Regenerative medicine. ; Biomedical engineering. ; Biomedical Research. ; Cell Biology. ; Biological Techniques. ; Regenerative Medicine and Tissue Engineering. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Biopharmaceuticals Produced from Cultivated Mammalian Cells -- Remote Control of Mammalian Therapeutic Designer Cells -- Next generation cell engineering using microRNAs -- An Omic’s data-driven approach towards engineering mammalian cell factories and bioprocesses for biopharmaceutical production -- Redesigning spent media from cell culture bioprocess to feed new bacterial fermentations -- Monoclonal antibody glycoengineering for biopharmaceutical quality assurance -- Next-generation cell engineering platform for improving recombinant protein production in mammalian cells -- Manufacturing human pluripotent stem cells and differentiated progenitors -- Biomanufacturing of Mesenchymal Stromal Cell for Therapeutic Applications -- Process Design for hMSC Products in Stirred Tank Bioreactors -- Bio-production of Adeno-associated virus for gene therapy -- Scale-up (and scale-down) of CHO cell culture, with a focus on how to adjust the various culture parameters/setpoints across different systems from lab-scale to manufacturing-scale -- Intensified and Continuous mAb Production with Single-Use Systems -- Mathematical modelling of cell culture processes -- Model-assisted design concepts for mammalian cell culture processes -- Bioprocess monitoring and control -- Industrial Monitoring of Cell Culture.
    Abstract: This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.
    Type of Medium: Online Resource
    Pages: X, 550 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030798710
    Series Statement: Cell Engineering, 10
    DDC: 610.72
    Language: English
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  • 29
    Keywords: Water. ; Hydrology. ; Geographic information systems. ; Sustainability. ; Environmental protection. ; Civil engineering. ; Water. ; Geographical Information System. ; Sustainability. ; Soil and Water Protection.
    Description / Table of Contents: Chapter 1. Introduction: Groundwater and Society: Applications of Geospatial Technology (Pravat Kumar Shit, Gouri Sankar Bhunia, Partha Pratim Adhikary, Ch. Jyotiprava Dash) -- Part I: Groundwater resources and societal development -- Chapter 2. Groundwater and Society in India: Challenging Issues and Adaptive Strategies (Subrata Jana) -- Chapter 3. Groundwater Research and Societal Development: Integration with Remote Sensing and Geographical Information System (Gouri Sankar Bhunia, Pravat Kumar Shit, Partha Pratim Adhikary and Debashish Sengupta) -- Chapter 4. Geospatial and Geophysical Approaches for Assessment of Groundwater Resources in an Alluvial Aquifer of India (Partha Pratim Adhikary, S.K.Dubey, Debashis Chakraborty, Ch. Jyotiprava Dash) -- Chapter 5. Groundwater and Space Technology: Issues and challenges (Gouri Sankar Bhunia, Pravat Kumar Shit, Harsha Das Gupta, Partha Pratim Adhikary) -- Part II: Groundwater availability, quality and pollution -- Chapter 6. Groundwater Quality through Multi-criteria based GIS Analysis: Village Level Assessment (Baisakhi Chakraborty, Sambhunath Roy, Gouri Sankar Bhunia, Debashish Sengupta, Pravat Kumar Shit) -- Chapter 7. GIS-based Fuzzy-AHP Approach for Assessment of Groundwater Potential Zones of an Urban Agglomeration (Suraj Kumar Mallick, Somnath Rudra) -- Chapter 8. Assessment of Groundwater Availability in Gumani River Basin, India using Geoinformatics and Analytical Hierarchy Process (Sadik Mahammad, Aznarul Islam) -- Chapter 9. Application of AHP for Groundwater Potential Zones Mapping in Plateau Fringe Terrain: Study from Western Province of West Bengal (Manas Karmakar, Monali Banerjee, Mrinal Mandal, Debasis Ghosh) -- Chapter 10. Performance of Frequency Ratio Approach for Mapping of Groundwater Prospect Areas in an Area of Mixed Topography (Subhas Garai, Pulakesh Das) -- Chapter 11. Artificial Neural Network for Identification of Groundwater Potential Zones in part of Hugli District, West Bengal, India (Chalantika Laha Salui and Shashank Yadav) -- Chapter 12. Multi-criteria Analysis for Groundwater Quality Assessment: A Study in Paschim Barddhaman District of West Bengal, India (Payel Das, Niladri Das) -- Chapter 13. Performance of WQI and HPI for Groundwater Quality Assessment: Study from Sangramgarh Colliery of West Burdwan District, West Bengal, India (Tanushree Paul, Manas Nath) -- Chapter 14. Assessment of Groundwater Quality interaction using One-decade Data: Case Study from a Hard Rock Area (S. Satheeshkumar, S. Venkateswaran, T. Maheshwari) -- Chapter 15. Fluoride Dynamics in Precambrian Hard Rock Terrain of North Singbhum Craton and Effect of Fluorosis on Human Health and Society (Biswajit Bera, Sumana Bhattacharjee, Meelan Chamling, Arijit Ghosh, Nairita Sengupta, Supriya Ghosh) -- Chapter 16. Coastal Aquifer Vulnerability for Saltwater Intrusion: A Case Study of Chennai Coast Using GALDIT Model and Geoinformatics (Debabrata Ghorai, Gouri Sankar Bhunia, Pravat Kumar Shit) -- Part III: Sustainable Groundwater resources management -- Chapter 17. Watershed Development Impact on Natural Resources: Groundwater and Surface Water Utilization (Partha Pratim Adhikary, M. Madhu, P. Jakhar, B.S. Naik, H.C. Hombegowda, D. Barman, G.B. Naik, Ch. J. Dash) -- Chapter 18. Long-term Groundwater Behaviour over an Agriculturally Developed State of North-West India: Trend and Impact on Agriculture (Omvir Singh, Amrita Kasana, Pankaj Bhardwaj) -- Chapter 19. Spatial Appraisals of Groundwater Recharge Potential Zone Identification using Remote Sensing and GIS (Gouri Sankar Bhunia, Pranab Kumar Maity, Pravat Kumar Shit) -- Chapter 20. Spatial Mapping of Groundwater Depth to Prioritize the Areas under Water Stress in Rayalaseema Region of Andhra Pradesh, India (Ch. Jyotiprava Dash, PP Adhikary, Uday Mandal) -- Chapter 21. Exploring Vulnerability of Groundwater using AHP and GIS Techniques: A Study in Cooch Behar District, West Bengal, India (Dipankar Saha, Debasish Talukdar, Ujjal Senapati, Tapan Kumar Das) -- Chapter 22. Applicability of Geospatial Technology, Weight of Evidence and Multilayer Perceptron for Groundwater Management: A Geoscientific Study on Birbhum District, West Bengal, India (Niladri Das, Subhasish Sutradhar, Ranajit Ghosh, Prolay Mondal) -- Chapter 23. Water resources management in semi-arid Purulia District of West Bengal, in the context of sustainable development goals (Amit Bera, Shubhamita Das).
    Abstract: This volume advances the scientific understanding, development, and application of geospatial technologies related to groundwater resource management, mapping, monitoring, and modelling using up-to-date remote sensing and GIS techniques. The book further provides a critical analysis of the debates and discourses surrounding groundwater resources and society, illustrates the relationship between groundwater resources and precision agriculture for societal development, and describes novel, region-specific management strategies and techniques for sustainability with case studies. The book is organized into three parts: (I) Groundwater resources and societal development; (II) Groundwater availability, quality and pollution; and (III) Sustainable groundwater resources management. Each section begins with a short introduction that includes an overview of the papers in that section. Individual chapters focus on the core themes of research and knowledge along with some topics that have received lesser attention. The book will be of interest to water resource planners and decision-makers, academic researchers, policy makers, NGOs, and academic researchers and students in Geography, Geophysics, Hydrology, Remote Sensing & GIS, Agriculture, Soil Science, and Agronomy.
    Type of Medium: Online Resource
    Pages: XVI, 534 p. 215 illus., 199 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030641368
    DDC: 551.48
    Language: English
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    Keywords: Water. ; Hydrology. ; Urban ecology (Biology). ; Sociology, Urban. ; Biotic communities. ; Tourism. ; Management. ; Water. ; Urban Ecology. ; Urban Sociology. ; Ecosystems. ; Tourism Management.
    Description / Table of Contents: Introduction. Reclaiming and rewilding river cities for outdoor recreation -- Cities and their waterways -- With rivers to the sea: Ecological restoration of rivers and estuaries and nature-based activities -- Behind good ecological status, the quest to reconquer water territories -- Planning and designing facilities that enhance rivers and encourage the development of tourist and recreational spaces: urban promenades -- Outdoor leisure activities at odds with the city. Arcachon Bay and the Massif des Calanques -- “On the conquest of wild nature” ... but what is meant by ‘nature’? -- The Darsena di Milano (Italy): ‘restoration’ of an urban artificial aquatic environment between citizens' hopes and municipal projects -- Grenoble, the river city facing the mountains (End 19th century-1930s) -- The role and significance of the recreational reconquest of port spaces: Rouen (France), reinvention at the neck of the estuary -- Recreational Activities, Economic and Territorial Development: Caen (France) in the Reconquest of its River? -- Bordeaux’s playful and sporty maritime life: a revolution of venues and activities.
    Abstract: The introduction of sports and recreational facilities into natural environments calls for reflection on their impact on fragile ecosystems. This book is unique in providing an interdisciplinary approach to the ecological restoration of urban and industrial degraded habitats and their use by nearby city-dwellers. For the first time ecologists, sociologists and anthropologists have worked together on particularly sensitive ecosystems such as rivers and estuaries to propose recovery strategies that allow their basic ecological functions to be restored, and which can benefit local populations through nature activities. Nonetheless, the use of natural spaces calls for the building of sustainable towns. This is why this book is distinctive in considering quality of life and well-being as stated objectives of modern river towns. Recently, leisure time has become a part of urban rhythms. In order to favour personal development, an extensive palette of leisure activities is considered by the authors: bird watching entertainment sports culture Many aspects including physical and psychological attributes in relation to the contemporary socio-political fabric are dealt with. While creating areas of freedom, landscaping also induces certain forms of practice and encourages certain social skills. Conversely, the book questions certain types of management based on mass consumption. Don’t they, in the end, aim to satisfy needs that are impermanent and shallow? The image of the contemporary town relies on urban planning projects which, in a global economy, seek to capture the interest of tourists and local populations. How can suitable, diligent planning be successfully combined with both creative design and ecological care? This book demonstrates how biology and sociology can (and should) work in harmony in order to promote an ecosystem approach to environmental management.
    Type of Medium: Online Resource
    Pages: V, 104 p. 38 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030487096
    Series Statement: Estuaries of the World,
    DDC: 551.48
    Language: English
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    Keywords: Water. ; Hydrology. ; Earth sciences. ; Physical geography. ; Natural disasters. ; Water. ; Earth Sciences. ; Earth System Sciences. ; Natural Hazards.
    Description / Table of Contents: Trend analyses of seasonal mean temperature Series pertaining to Tapi river basin, using monthly data -- . Dry and wet spell characterization of Naini river basin, western Maharashtra, India -- Assessment of Climate Change on Crop Water Requirement in Tandula Command of Chhattisgarh (India) -- Impact of climate change on hydrological regime of Narmada river basin -- Climate change impacts on water resource in Ethiopia -- Spatio-temporal trend analysis of long term IMD gridded precipitation in Godavari river basin, India -- Forecasting reference evapotranspiration using artificial neural network for Nagpur Region -- Assessment of extremes using time varying downscaling model -- Assessment of impact of land use land cover and climate change on quality of river using water quality index -- Assessment of tail behavior of probability distributions of daily precipitation data over India -- Probabilistic prediction of monthly streamflow using graphical modeling approach. .
    Abstract: This book provides insights and a capacity to understand the climate change phenomenon, its impact on water resources, and possible remedial measures. The impact of climate change on water resources is a global issue and cause for concern. Water resources in many countries are extremely stressed, and climate change along with burgeoning populations, the rise in living standards, and increasing demand on resources are factors which serve to exacerbate this stress. The chapters provide information on tools that will be useful to mitigate the adverse consequences of natural disasters. Fundamental to addressing these issues is hydrological modelling which is discussed in this book and ways to combat climate change as an important aspect of water resource management.
    Type of Medium: Online Resource
    Pages: XVI, 551 p. 223 illus., 199 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030642020
    Series Statement: Water Science and Technology Library, 98
    DDC: 551.48
    Language: English
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    Keywords: Water. ; Hydrology. ; Pollution. ; Environmental chemistry. ; Refuse and refuse disposal. ; Water. ; Pollution. ; Environmental Chemistry. ; Waste Management/Waste Technology.
    Description / Table of Contents: Preface -- Chapter 1 Emerging Contaminants: Remediation -- Chapter 2 Electrochemical Treatments for the Removal of Emerging Contaminants -- Chapter 3 Technologies to Remove Selenium From Water and Wastewater -- Chapter 4 Advanced Treatments for the Removal of Alkylphenols and Alkylphenol Polyethoxylates from Wastewater -- Index.
    Abstract: Emerging contaminants are chemical and biological agents for which there is growing concern about their potential health and environmental effects. The threat lies in the fact that the sources, fate and toxicology of most of these compounds have not yet been studied. Emerging contaminants, therefore, include a large number of both recently discovered and well-known compounds such as rare earth elements, viruses, bacteria, nanomaterials, microplastics, pharmaceuticals, endocrine disruptors, hormones, personal care products, cosmetics, pesticides, surfactants and industrial chemicals. Emerging contaminants have been found in many daily products, and some of them accumulate in the food chain. Correlations have been observed between aquatic pollution by emerging contaminants and discharges from wastewater treatment plants. Most actual remediation methods are not effective at removing emerging contaminants. This second volume presents comprehensive knowledge on emerging contaminants with a focus on remediation.
    Type of Medium: Online Resource
    Pages: XVI, 401 p. 65 illus., 43 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030690908
    Series Statement: Environmental Chemistry for a Sustainable World, 66
    DDC: 551.48
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Water. ; Hydrology. ; Marine engineering. ; Water. ; Marine Engineering.
    Description / Table of Contents: Introduction -- Ship ballast water management system -- Working Principle of ballast water management system -- The key components of the system and the working principle of the unit -- Design method of key components -- Optimization of key components -- Development of control system for ballast water management system -- Maintenance and management of ballast water management system -- Implementation of ballast water management system on ships.
    Abstract: This book introduces the components and principles of the common ballast management systems. The working principles of different filtration, cleaning and sterilizing equipment are also introduced. The calculation norm of the construction design and the calculation method of simulation are described. Besides, different aspects of system management are analyzed. The principle of various detecting sensors, the hardware of control system and the design method of human–computer interface are respectively introduced. Last but not least, the maintenance and management of ballast water management system are described, mainly the maintenance and management of key components which composes the system. .
    Type of Medium: Online Resource
    Pages: IX, 285 p. 233 illus., 172 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813368651
    DDC: 551.48
    Language: English
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  • 34
    Keywords: Water. ; Hydrology. ; Environmental health. ; Environmental monitoring. ; Bioclimatology. ; Refuse and refuse disposal. ; Water. ; Environmental Health. ; Environmental Monitoring. ; Climate Change Ecology. ; Waste Management/Waste Technology.
    Description / Table of Contents: Foreword -- Preface -- 1. Water Pollution and Water Quality Assessment, Environmental Flows -- 2. Water Treatment Technologies and Management -- 3. Climate Change and Climate Variability -- 4. Water and Human Health Issues -- 5. Conclusions. .
    Abstract: This book chiefly focuses on environmental flow, water pollution and water quality. Several chapters also cover water treatment technologies and management. In today’s context, climate change and climate variability are important issues in the water sector, which is called upon to develop adaptation strategies to cope with their negative impacts. Human health depends upon the quality of water used for drinking and irrigation purposes. These core issues are discussed and addressed in several chapters. The book explores the impact of climate change on water resources and considers various climatological scenarios. In this regard, it carries out a trend analysis and compares the performance of various Global Climate Models (GCMs). Further, it conducts a water quality analysis and water quality mapping so as to provide information on the most vulnerable areas in the context of water quality. Emerging pollutants, generated from paper mills, are identified in order to choose an appropriate treatment technology. Bioremediation techniques are included for the characterization of improved water quality parameters. The book also presents a low-cost treatment technology for fluoride removal, which can help water managers ensure potable water to stakeholders. In terms of maintaining river ecology in the downstream areas of water resources project sites, the book provides a number of case studies on assessment of environmental flows. Advanced treatment technologies that can be highly advantageous for removing water pollutants are presented. Given its scope, the book offers a valuable resource for academics, water resources practitioners, scientists, water managers, environmentalists, administrators, NGOs, researchers and students who are involved in water management with a main focus on water pollution, the environment, climate change and health. .
    Type of Medium: Online Resource
    Pages: XIII, 392 p. 142 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030514273
    Series Statement: Water Science and Technology Library, 95
    DDC: 551.48
    Language: English
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  • 35
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Water. ; Hydrology. ; Environmental geography. ; Geomorphology. ; Sedimentology. ; Geology. ; Landscape ecology. ; Water. ; Integrated Geography. ; Geomorphology. ; Sedimentology. ; Geology. ; Landscape Ecology.
    Description / Table of Contents: Changjiang River basin Overview -- Hydrological Processes of the Changjiang River -- Lake hydro-morphodynamic Processes of the Changjiang River -- Channel sediment-dynamics along the mid-lower reach of the Changjiang River -- Tidal flat morphodynamics of the Changjiang Estuary -- Changjiang Estuary modern morphodynamic processes -- Estuarine submerged delta modern morphodynamics -- Morphodynamic couplings between river and delta.
    Abstract: This book provides a comprehensive and systematic analysis of the morphodynamic process of the Changjiang River from upstream to estuary in the Anthropocene. As the longest river in China, the Changjiang River has nurtured Chinese civilization with ample natural resources for thousands of years. Evidence highlights that the Changjiang River has experienced intensive human interference and indicated dramatic changes in the Anthropocene, including “no flood in flood season, no dry in dry season” in discharge; “less flood in flood season, more dry in dry season” in sediment; riverbed shifts from accretion to erosion; lakes in the middle-lower reach turn from sediment sink to source; estuarine tidal flat exhibits self-organization characteristics and maintains the current accretion state; estuarine branches that connect to the sea show district morphodynamic patterns; and depocenters of the submerged delta indicate periodic shifts. The book stresses that dam construction upstream, practically the Three Gorges Dam, the world’s largest hydraulic engineering project, has significant influences on the hydrology and geomorphology of the middle-lower reach but has a slight effect on estuarine delta development. The geomorphological structure of the estuarine channel is dominated by local land reclamation, navigation, and dredging. This book clarifies the river-estuary morphodynamics of the Changjiang River and indicates the general features of global mega rivers under human interference as well as their own response mechanisms. This book also exhibits the potential risk of river-estuary deltas in the future, as both material and dynamics are experiencing acceleration adjustment.
    Type of Medium: Online Resource
    Pages: XXI, 358 p. 247 illus., 237 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811637711
    DDC: 551.48
    Language: English
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  • 36
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Agriculture. ; Pollution. ; Sustainability. ; Environmental management. ; Water. ; Agriculture. ; Pollution. ; Sustainability. ; Environmental Management.
    Description / Table of Contents: Chapter 1. Nature and Origin of Salts, Classification, Area and Distribution of Salt-affected Soils -- Chapter 2. Saline Soils -- Chapter 3. Management and Reclamation of Saline Soils -- Chapter 4. Biodrainage -- Chapter 5. Alkali Soils -- Chapter 6. Reclamation and Management of Alkali Soils for Crop Production -- Chapter 7. Nutrient Management in Salt-affected Soils -- Chapter 8. Irrigation Water: Quality Criteria -- Chapter 9. Irrigation and Salinity Control -- Chapter 10. Wastewaters as Non-conventional Sources of Irrigation -- Chapter 11. Trees and Grasses as Alternate Strategies for Management of Salt-affected Soils -- Chapter 12. Environmental Impact of Reclamation of Salt-affected Soils and Intensive Irrigated Agriculture.
    Abstract: This book presents systematic scientific appraisal, classification, genesis and viable technologies for reclamation and management of salt-affected soils and marginal quality waters across India and several other countries. Nature, solubility and geo-chemical mobility of salts have been provided as basis for the development of alkali and saline soils and groundwaters under specific agro-hydro-ecological regions. Chemical amendment (gypsum) based reclamation technology of alkali soils and related pre and post-reclamation water, nutrient and crop management interventions, including re-sodification issues have been comprehensively addressed. Features and operational guidelines of surface, subsurface, vertical and bio-drainage systems have been thoroughly discussed; likewise, amelioration of irrigation induced saline soils in inland and coastal regions and preventive measures for control of salinity and waterlogging along with environmental trade-offs. Practical approaches for amelioration and judicious use of saline, alkali, high SAR- saline and waste waters have been synthesized for different cropping and agro- forestry systems. Emerging issues on use of industrial by-products as amendments for alkali soils, physiological aspects of salt resistance, anatomical and biochemical mechanism of submergence tolerance, specific ion effects of poor quality waters, crop diversification, groundwater recharge, rejuvenation of tsunami affected coastal soils, safety against occurrence of poisonous gas in tube well pits, paddy straw burning and others have been adequately deliberated upon. Combining scientific principles with field experiences, the book is expected to serve as a useful knowledge base for research workers, teachers and students of soil science, agronomy, plant breeding, forestry, irrigation engineering, extension workers, environmentalists and planners associated with reclamation and management of salt affected soils and waters on sustainable basis in developing and developed countries.
    Type of Medium: Online Resource
    Pages: XXII, 714 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030784355
    DDC: 551.48
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Animal culture. ; Water. ; Animal Science.
    Description / Table of Contents: Chapter 1 : Introduction -- Chapter 2: Interpretive Framework and Methodology -- Chapter 3: The English Inshore Fleet -- Chapter 4: Perceptions of Vulnerability in the English SSF -- Chapter 5: Strategies of Resilience in the English SSF -- Chapter 6: Discussion of the Resilience Strategies -- Chapter 7: Conclusion.
    Abstract: This book is a contribution to our understanding of the worrying situation of small-scale fisheries (SSF) which face marginalisation in most coastal countries. The authors explain why SSF are so pressured; how there has been a powerful backlash against this marginalisation during the last 30 years; what are the main ideational currents supporting this backlash; and what is the enduring value of SSF that justifies that support. The authors discuss the major contemporary interpretations of SSF; the challenges facing SSF globally and in England; and SSF’s coping strategies in response to those challenges through the framework of resilience theory. In an innovative analysis, the authors show how there are three kinds of resilience: passive resilience (where fishers are resigned to their adverse fate), adaptive resilience (where fishers make the best use of the opportunities that are available to them), and transformative resilience (where fishers attempt to change the system that faces them). The authors draw on an extensive range of interview data to provide rich insights into the world of SSF, and they discuss a variety of proposals for improving their conditions. The book will appeal to the growing academic and public community that is following with increasing concern the debate about the future of SFF, and to the environmental movement which has committed itself to support SSF as a greener form of fishing than the large-scale industrial sector.
    Type of Medium: Online Resource
    Pages: XII, 186 p. 2 illus., 1 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030542450
    DDC: 551.48
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Sustainability. ; Environmental management. ; Economic policy. ; Social policy. ; Communication. ; Water. ; Sustainability. ; Environmental Management. ; Socio-Economic Policy. ; Media and Communication.
    Description / Table of Contents: Chapter 1, Introduction -- Chapter 2. Water Supply in Cape Town -- Chapter 3. Reconciliation strategy -- Chapter 4. Politics, trust and governance -- Chapter 5. The Drought -- Chapter 6. Reliance on rainfall, climate variability and climate change -- Chapter 7. The Water Resilience Programme -- Chapter 8. The New Water Programme -- Chapter 9. NWP: Managing dam levels -- Chapter 10. NWP: Managing Demand -- Chapter 11. NWP: Augmentation -- Chapter 12. Lessons learnt -- Chapter 13. Conclusion.
    Abstract: The book presents the history of water supply to Cape Town, leading up to the worst ever drought recorded, through political turmoil impacting on drought interventions and resulting in the adoption of an integrated water strategy. Regions reliant on water supply from rainfed dams have always been vulnerable to the impact of drought. This is exacerbated by the uncertainty of future rainfall, which is never guaranteed, and reliance is placed on modelling using historic data. While weather has always been variable, climate has been generally reliable. With anthropogenic activity causing changes in climate, the validity of modelling based on history is currently not fully trusted. Unless the storage capacity is sufficient to carry through numerous seasons of poor rainfall, even with water restrictions to match demand and supply in times of depleted rainfall, the risk of reservoirs running dry remains a threat.
    Type of Medium: Online Resource
    Pages: XXIX, 290 p. 82 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030788896
    DDC: 551.48
    Language: English
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    Keywords: Water. ; Hydrology. ; Water-power. ; Environment. ; Geography. ; Water. ; Hydroenergy. ; Environmental Sciences. ; Geography.
    Description / Table of Contents: 1. Introduction -- 2. Pre-colonial, Colonial and Post-Colonial Era: A Look into the Historical Depths of the Nile Waters: What to Learn from History -- 3. Global Perspectives and Regional Lessons: The Nile River and The Prospects of The Grand Ethiopian Renaissance Dam -- 4. Beyond GERD: Hydropolitical, Hydrological, Technological and Investment (HHTI) Imperatives for Sustained Economic Cooperation -- 5. Water Resources Account of Egypt vs Ethiopia's Nile Sub-basins: The Utility of the Concept of Water Budget -- 6. Geographical Dimensions of Hydro-politics: The Case of Nile and Mekong Rivers.
    Abstract: This book is a contribution by the presenters of the 2020 International Conference on the Nile and Grand Ethiopian Renaissance Dam (GERD). The Nile basin is facing unprecedented level of water right challenges after the construction of GERD has begun. Ethiopia, Egypt and Sudan have struggled to narrow their differences on filling and operation of the GERD. The need for science and data-based discussion for a lasting solution is crucial. Historical perspectives, water rights, agreements, failed negotiations, and other topics related to the Nile is covered in this book. The book covers Nile water claims past and present, international transboundary basin cooperation and water sharing, Nile water supply and demand management, Blue Nile/Abbay and Grand Ethiopian Renaissance Dam, land and water degradation and watershed management, emerging threats of the Lakes Region in the Nile Basin, and hydrologic variation and monitoring. This book is beneficial for students, researchers, sociologists, engineers, policy makers, lawyers, water resources and environmental managers and for the people and governments of the Nile Basin.
    Type of Medium: Online Resource
    Pages: IX, 525 p. 158 illus., 147 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030764371
    Series Statement: Springer Geography,
    DDC: 551.48
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Nanobiotechnology. ; Biomedical Research. ; Cell Biology. ; Nanobiotechnology.
    Description / Table of Contents: Chapter 1. Nanomaterials and Stem Cells for Bone Tissue Engineering -- Chapter 2. The Application of Nanomaterial in Skeletal Muscle Regeneration -- Chapter 3. Application of Nanomaterials in Neurodegenerative Diseases -- Chapter 4. Application of Nano Drug Delivery Systems in Inhibition of Tumors and Cancer Stem Cells -- Chapter 5. The Application and Problems of Tetrahedral Framework Nucleic Acids as a Drug Carrier in Biomedicine Fields -- Chapter 6. Research Progress on Antibacterial Application with Nucleic Acid and Nucleic Acid Materials -- Chapter 7. The Application of DNA Nanostructures in Vaccine Technology.-.
    Abstract: This book aims to comprehensively summarize the current research status of nanomaterials and cell biology. It highlights the biological effects and biomedical applications of nanomaterials for specific diseases, bone tissue engineering, and skeletal muscle regeneration. It also provides the details of the biomedical applications of nucleic acid nanomaterials in drug delivery carriers, antimicrobial therapy, vaccine, and neurodegenerative diseases. Therefore, this book renders the audience a better understanding of nanomaterials along with the diverse applications in the cell biology field from recent works to perspectives.
    Type of Medium: Online Resource
    Pages: IX, 219 p. 13 illus., 11 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811626661
    DDC: 610.72
    Language: English
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  • 41
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Education Data processing. ; Image processing Digital techniques. ; Computer vision. ; Anatomy. ; Computer simulation. ; Biomedical engineering. ; Biomedical Research. ; Computers and Education. ; Computer Imaging, Vision, Pattern Recognition and Graphics. ; Anatomy. ; Computer Modelling. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: Evaluating the Efficacy and Optimisation of the Peer-led Flipped Model Using TEL Resources Within Neuroanatomy -- Observation of Patients’ 3D Printed Anatomical Features and 3D Visualisation Technologies Improve Spatial Awareness for Surgical Planning and in-Theatre Performance -- Pandemics, Protests and Pronouns: The Changing Landscape of Biomedical Visualisation and Education -- What Not to Do with PPE: A Digital Application to Raise Awareness of Proper PPE Protocol -- The Embryonic re-Development of an Anatomy Museum -- Visualising the Link Between Carpal Bones and their Etymologies -- Augmented Reality Application of Schizocosa Ocreata: A tool for Reducing Fear of Arachnids Through Public Outreach -- The Surgical Art Face©: Developing a Bespoke Multimodal Face Model for Reconstructive Surgical Education -- Modernizing Medical Museums Through the 3D Digitization of Pathological Specimens -- An Introduction to Biomedical Computational Fluid Dynamics.
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. The chapters presented in this volume cover such a diverse range of topics, with something for everyone. We present here chapters on technology enhanced learning in neuroanatomy; 3D printing and surgical planning; changes in higher education utilising technology, decolonising the curriculum and visual representations of the human body in education. We also showcase how not to use protective personal equipment inspired by the pandemic; anatomical and historical visualisation of obstetrics and gynaecology; 3D modelling of carpal bones and augmented reality for arachnid phobias for public engagement. In addition, we also present face modelling for surgical education in a multidisciplinary setting, military medical museum 3D digitising of historical pathology specimens and finally computational fluid dynamics. .
    Type of Medium: Online Resource
    Pages: XVI, 223 p. 141 illus., 125 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030769512
    Series Statement: Advances in Experimental Medicine and Biology, 1334
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Microbiology. ; Nanotechnology. ; Chemistry. ; Nanoparticles. ; Biomedical Research. ; Microbiology. ; Nanotechnology. ; Nanoparticle Synthesis.
    Description / Table of Contents: Chapter 1_Introduction to Microbial synthesis of Nanoparticles: advantages, disadvantages and prospects -- Chapter 2. Prokaryotic and microbial eukaryotic system for the NP synthesis -- Chapter 3. Enzymes involved in the extra and intracellular synthesis of nanoparticles -- Chapter 4. Bacterial synthesis of NPs and their scale-up technologies -- Chapter 5. Fungal biogenesis of NPs and their limitations -- Chapter 6. A Role of virus in nanoparticle synthesis. -- Chapter 7. The Algal biogenesis of NPs -- Chapter 8. Protozoa, an emerging candidate for the synthesis of NPs -- Chapter 9. Industrial Perspective of microbial application for NP synthesis -- Chapter 10. Microbial nanotechnology in treating multidrug resistance pathogens. -- Chapter 11. Microbial nanoparticles for cancer treatment -- Chapter 12. Role of microbial nanotechnology in diagnostic -- Chapter 13. Application of microbial nanotechnology in agriculture -- Chapter 14. Management of plant fungal disease by microbial nanotechnology -- Chapter 15. Microbial nanotechnology for bioremediation of heavy metals -- Chapter 16. Medical and cosmetic applications of microbial nanotechnology -- Chapter 17. Comparative analysis of cellular internalization propensity between the commercial and microbial assisted nanoparticles.
    Abstract: This book introduces the principles and mechanisms of the biological synthesis of nanoparticles from microorganisms, including bacteria, fungi, viruses, algae, and protozoans. It presents optimization processes for synthesis of microbes-mediated nanoparticles. The book also reviews the industrial and agricultural applications of microbially-synthesized nanoparticles. It also presents the medical applications of green nanoparticles, such as treating multidrug-resistant pathogens and cancer treatment. Further, it examines the advantages and prospects for the synthesis of nanoparticles by microorganisms. Lastly, it also presents the utilization of microbial-synthesized nanoparticles in the bioremediation of heavy metals.
    Type of Medium: Online Resource
    Pages: VIII, 359 p. 47 illus., 44 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811619236
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Neurosciences. ; Biomedical Research. ; Neuroscience.
    Abstract: This volume highlights the recent advances in the understanding of the endocannabinoid system and the likely benefit from the therapeutic effects of cannabinoid treatment in a variety of health issues. Archeological evidence has shown that Cannabis has a long history of use for multiple purposes, including the treatment of medical conditions. The primary active constituent of the hemp plant Cannabis sativa, delta 9-tetrahydrocannabinol (Δ9-THC), causes euphoria, enhancement of sensory perception, tachycardia, antinociception, difficulties in concentration and impairment of memory, among other effects. Despite these undesirable effects, signaling is mostly inhibitory and suggests a putative role for cannabinoids as therapeutic agents by managing several diseases where inhibition of neurotransmitter release would be beneficial. The themes of this book have been edited and written by world-leaders in the field, The contents of the volume aims at readers from a range of academic and professional disciplines, such as biomedicine, several areas of biology, neurology, clinical medicine and pharmacy.
    Type of Medium: Online Resource
    Pages: XVII, 153 p. 43 illus., 4 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030573690
    Series Statement: Advances in Experimental Medicine and Biology, 1264
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Medical sciences. ; Genetics. ; Biochemistry. ; Neurosciences. ; Biomedical Research. ; Health Sciences. ; Genetics and Genomics. ; Biochemistry. ; Neuroscience.
    Description / Table of Contents: Chapter 1. MTOCHONRIAL NEUROLOGY: A TALE OF TWO GENOMES (Salvatore DiMauro and Emanuele Barca) -- Chapter 2. Mutations in assembly factors required for the biogenesis of mitochondrial respiratory chain (Cristina Cerqua, Lisa Buson and Eva Trevisson) -- Chapter 3. Mitochondrial DNA: defects, maintenance genes and depletion (Miguel A. Fernández-Moreno, Luis Vázquez-Fonseca, Sara Palacios Zambrano and Rafael Garesse) -- Chapter 4. Mitochondrial translation deficiencies (Veronika Boczonadi, Juliane S. Müller and Rita Horvath) -- Chapter 5. Mitochondria dynamics: definition, players and associated disorders (Maria EugeniaSoriano, Marta Carro Alvarellos, Giovanni Rigoni, and Luca Scorrano) -- Chapter 6. Coenzyme Q biosynthesis disorders (Gloria Brea-Calvo, María Alcázar-Fabra, Eva Trevisson and Plácido Navas) -- Chapter 7. Cytochrome c defects in human disease (Leonardo Salviati) -- Chapter 8. Biochemical diagnosis of mitocondrial disorders (Delia Yubero, Raquel Montero, Rafael Artuch) -- Chapter 9. Molecular genetics in the Next Generation Sequencing era (Joaquin Dopazo) -- Chapter 10. Model cells and organisms in mitochondrial diseases (Rhoda Stefanatos, Alberto Sanz, Daniel J M Fernandez-Ayala) -- Chapter 11. Therapies approaches in mitochondrial diseases (Valentina Emmanuele, Catarina M Quinzii, and Michio Hirano).
    Abstract: Mitochondrial diseases comprise a clinically and genetically heterogeneous group of rare disorders that may affect virtually any system of the body at any age. Due to their complexity, understanding and diagnosing these diseases requires a multidisciplinary approach. This book provides an update on the major features of human mitochondrial diseases: genetic bases, pathophysiology, diagnosis, and treatment, and of the new technologies involved in the diagnosis and on the characterization of patients. The 11 chapters examine the unique complex interactions between the mitochondrial and the nuclear genomes involved in the biogenesis and the regulation of the mitochondrial respiratory chain, and their relevance to human disease. We discuss the traditional biochemical and genetic approaches, as well as the new omic technologies, and the cellular and animal models used in mitochondrial research. The last chapter is dedicated to the current treatment options. Authors are worldwide experts in these fields and integrate expertise in both basic science and clinical research. This book is particularly important for both scientists and clinicians interested in the diagnosis and treatment of these diseases.
    Type of Medium: Online Resource
    Pages: VI, 305 p. 29 illus., 23 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030701475
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Biomedical Research.
    Description / Table of Contents: Part I. Oxygen Metabolism and Health Monitoring -- Chronic Ketosis Modulates HIF1α Mediated Inflammatory Response in Rat Brain -- Event Related NIRS and EEG Analysis for Mental Stress Monitoring -- Simulation Study of Breast Cancer Lipid Changes Affecting Membrane Oxygen Permeability -- Updated Evaluation of Cholesterol’s Influence of Oxygen Permeability -- Systems biology model of cerebral oxygen delivery and metabolism during therapeutic hypothermia: application to the piglet model -- Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model -- Two consecutive invasive surgeries utilizing Zymogen Protein C (ZPC) that enhanced patient safety and reduced costs -- Scanning Tissue-Oxygen Needle-Probe -- Transcranial photobiomodulation of clearance of beta-amyloid from the mouse brain: the effects on meningeal lymphatic drainage and blood oxygen saturation of the brain -- Near-Infrared Spectroscopy Might Help Prevent Onset of Cerebral Hyperperfusion Syndrome -- Part II. Oxygen Measurement and Modeling -- Online assessment of hemodynamics in suctioned volume of biological tissue by the embedded Near-infrared Spectroscopy sensor -- Skeletal Muscle Deoxygenation and its Relationship to Aerobic Capacity During Early and Late Stages of Aging -- Near-Infrared Spectroscopy (NIRS) of Muscle HbO2 and MBO2 Desaturation During Exercise -- Relationship between Corticosteroid Dose and Muscle Oxygen Consumption in Recipients of Hematopoietic Stem-Cell Transplantation -- Relationship between the Borg Scale Rating of Perceived Exertion and Leg Muscle Deoxygenation during Incremental Exercise in Healthy Adults -- Effects of Exercise Training on Cardiac and Skeletal Muscle Functions in Patients in Chronic Heart Failure -- Reduced Scattering Coefficient During Incremental Exercise is Constant without being Affected by Changes in Muscle Oxygenation or Hemodynamics -- Changes in the laterality of oxygenation in the prefrontal cortex and premotor area during a 20-min moderate-intensity cycling exercise -- Relationship Between Decrease of Oxygenation During Incremental Exercise, Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis -- Cerebral Oxygenation Dynamics during Incremental Exercise: Comparison of Arm Cranking and Leg Cycling -- Localization of Deep of Deep Ischemia and Hemorrhage in Preterm Infants’ Head with Near Infrared Optical Tomography: A Numerical Case Study -- Discerning Membrane Steady-State Oxygen Flux by Monte Carlo Markov Chain Modeling -- Part III. Tumor Oxygenation and Modeling -- Role of MicroRNA Expression for Proliferation and Apoptosis of Tumor Cells: Impact of Hypoxia-Related Acidosis -- Functional Impact of Acidosis-regulated MicroRNAs on the Migration and Adhesion of Tumor Cells -- Impact of Acidosis-Regulated MicroRNAs on the Expression of Their Target Genes in Experimental Tumors In Vivo -- An Observation on Enhanced Extracellular Acidification and Lactate Production Induced by Inhibition of Lactate Dehydrogenase A -- Keynote Lecture - The Warburg Effect: Historical Dogma versus Current Rationale -- The Acidic Tumor Microenvironment Affects Epithelial-Mesenchymal Transition Markers as well as Adhesion of NCI-H358 Lung Cancer Cells -- Assessment of the probability of tumor control for prescribed doses based on imaging of oxygen partial pressure -- On the feasibility of Pulse Wave Velocity Imaging for remote assessment of physiological functions -- Mechanisms of sound-induced opening of the blood-brain barrier -- Multimodal measurements of brain tissue metabolism and perfusion in a neonatal model of hypoxic-ischaemic injury -- Cerebral Spreading Depression Transient Disruption of Cross Frequency Coupling in the Rat Brain: Preliminary Observations -- Long-Term Blue Light Exposure Changes Frontal and Occipital Cerebral Hemodynamics: Not all Subjects React the Same -- Changes in Prefrontal Cortex Asymmetry Due to Standing Loading in Stroke Patients Measured by NIRS -- Parasympathetic Nervous Activity Associated with Discoordination between Physical Acceleration and Heart Rate Variability in Patients with Sleep Apnea -- The Changes in Brain Oxygenation during Transcranial Alternating Current Stimulation as Consequences of Traumatic Brain Injury: A Near-infrared Spectroscopy Study -- Error Evaluation for Automated Diameter Measurements of Cerebral Capillaries Captured with Two-Photon Laser Scanning Fluorescence Microscopy -- Potential Biomarker for Triple Negative Breast Cancer Invasiveness by Optical Redox Imaging -- Optical redox imaging differentiates triple-negative breast cancer subtypes -- Oxygen-sensing Paramagnetic Probes for Clinical Oximetry -- Evaluation of the Quality of Chest Compression with Oxy-hemoglobin Level by Near-infrared Spectroscopy in a Rat Asphyxia Cardiac Arrest Model -- Altered Behavioural Performance in the Neuron-specific HIF-1 and HIF-2 deficient mice following Chronic Hypoxic Exposure -- Effect of Adrenaline on Cerebral Blood Oxygenation Measured by NIRS in a Rat Asphyxia Cardiac Arrest Model -- Addition of Drag Reducing Polymers to Colloid Resuscitation Fluid Enhances Cerebral Microcirculation and Tissue Oxygenation after Traumatic Brain Injury Complicated by Hemorrhagic Shock -- Effects of 20-minute intensive exercise on subjects with different working memory bases -- Supine cycling exercise enhances cerebral oxygenation of motor-related areas in healthy male volunteers -- Keynote Lecture - What is the Meaning of an Oxygen Measurement? Analysis of methods purporting to measure oxygen in targeted tissues -- Part IV. Brain Oxygenation and Function -- Assessment of Cerebral Blood Oxygenation by Near-Infrared Spectroscopy before and after Resuscitation in A Rat Asphyxia Cardiac Arrest Model -- Effect of 3-Day and 21-Day Hypoxic Preconditioning on Recovery following Cerebral Ischemia in Rats -- Time Series Tracking of Cerebral Microvascular Adaptation to Hypoxia and Hyperoxia Imaged with Repeated in vivo Two-Photon Microscopy -- Environmental Enrichment Improved Cognitive Performance in Mice under Normoxia and Hypoxia -- Effect of Prolonged Pressure on Hemodynamics of Sacral Tissues Assessed by Diffuse Optical Imaging: A Pilot Study -- In-phantom Validation of Time-Domain Near-Infrared Optical Tomograph Pioneer for Imaging Brain Hypoxia and Hemorrhage -- Online Non-invasive Assessment of Human Brain Death by Near-infrared Spectroscopy with Protocol of O2 Inspiration -- Not removing the glossy white cover from adhesive INVOS neonatal sensors affects the oxygenation measurement -- Probe design optimization for time-domain NIROT ‘Pioneer’ system for imaging the oxygenation of the preterm brain -- Effect of blood flow on hemoglobin and myoglobin oxygenation in contracting muscle using near infrared spectroscopy -- Magnetoresistance Properties of Red Blood Cells in Plasma Combined with Several Magnetic Beads Passing Two Cu Electrodes -- Measurement of Tissue Oxygen as a Novel Approach to Optimizing Red Blood Cell Quality Assessment -- Prox-1 and Hif-1a Genes Expression of Primo Vessel in Rabbit’s Lymphatic Vessel -- On the Feasibility of Pulse Wave Velocity Imaging for Remote Assessment of Physiological Functions -- Index.
    Abstract: This book presents cutting-edge papers and perspectives on the transport of oxygen to tissues by scientists in a multitude of disciplines such as biochemistry, engineering, mathematics, medicine, physics, physiology, veterinary and complementary medicine. The book is composed of the following 6 parts: Brain Oxygenation and Function, Tumor Oxygenation and Metabolism, Muscle Oxygenation and Sports Medicine, Cell Metabolism and Tissue Oxygenation, Methodology of O2 Measurements, and Special Topics. The articles in this book have been presented at the 42nd annual meeting of the International Society on Oxygen Transport to Tissue (ISOTT 2019) held in Albuquerque, New Mexico, USA, from July 28 to July 31, 2019. Academics, clinical and industry researchers, engineers, as well as graduate students who are interested in oxygen transport to tissue will find this book a great reference and a useful learning resource. The chapters "Near-Infrared Spectroscopy Measured Cerebral Blood Flow from Spontaneous Oxygenation Changes in Neonatal Brain Injury", "Developing a Model to Simulate the Effect of Hypothermia on Cerebral Blood Flow and Metabolism" and "Broadband NIRS Cerebral Evaluation of the Hemodynamic and Oxidative State of Cytochrome-c-Oxidase Responses to +Gz Acceleration in Healthy Volunteers" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: XVI, 412 p. 166 illus., 95 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030482381
    Series Statement: Advances in Experimental Medicine and Biology, 1269
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Biomedical engineering. ; Bioinformatics. ; Biotechnology. ; Image processing Digital techniques. ; Computer vision. ; Biomedical Research. ; Biomedical Engineering and Bioengineering. ; Computational and Systems Biology. ; Biotechnology. ; Computer Imaging, Vision, Pattern Recognition and Graphics.
    Description / Table of Contents: Chapter 1. Pair-Matching Digital 3D Models Of Temporomandibular Fragments Using Mesh-To-Mesh Value Comparison And Implications For Commingled Human Remain Assemblages (Alana S. Acuff, Mara A. Karell, Konstantinos E. Spanakis, And Elena F. Kranioti) -- Chapter 2. Forensic Recreation And Visual Representation Of Greek Orthodox Church Saint, Eftichios of Crete (Nectarios Vidakis, Markos Petousis, Despoina Nathena, Elena F. Kranioti, Andreas Manios) -- Chapter 3. Virtual Trauma Analysis Of The 19th Century Severed Head Of The Greek Outlaw Stavrou (Elena F. Kranioti, Nikos Tsiatis, Kristina Frandson, Maria Stefanidou, Konstantinos Moraitis) -- Chapter 4. Using Computed Tomography (CT) Data To Build 3D Resources For Forensic Craniofacial Identification (Terrie Simmons-Ehrhardt, Catyana R.S. Falsetti, Anthony B. Falsetti) -- Chapter 5. Instructional Design Of Virtual Learning Resources For Anatomy Education (Nicolette S. Birbara, Nalini Pather) -- Chapter 6. Implementation Of Ultrasound In Anatomy Education (Claire Smith And Seb Barfoot) -- Chapter 7. What The Tech? The Management Of Neurological Dysfunction Through The Use Of Digital Technology (Caitlin Carswell And Paul M. Rea) -- Chapter 8. Teaching With Disruptive Technology: The Use Of Augmented, Virtual, And Mixed Reality (Hololens) For Disease Education (Zane Stromberga, Charlotte Phelps, Jessica Smith & Christian Moro) -- Chapter 9. “Inform the Head, Give Dexterity to the Hand, Familiarise the Heart”: Seeing and Using Digitised Eighteenth-Century Specimens in a Modern Medical Curriculum (Frances Osis) -- Chapter 10. Contact-Free Pulse Signal Extraction From Human Face Videos: A Review And New Optimised Filtering Approach (Muhammad Waqar, Reyer Zwiggelaar And Bernard Tiddeman).
    Abstract: This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way. It will enable those interested in visualisation techniques to gain a better understanding of the applications that can be used in visualisation, imaging and analysis, education, engagement and training. The reader will also be able to learn about the use of visualisation techniques and technologies for the historical and forensic settings. The reader will be able to explore the utilisation of technologies from a number of fields to enable an engaging and meaningful visual representation of the biomedical sciences. In this volume, there are chapters which examine forensic and historical visualisation techniques and digital reconstruction, ultrasound, virtual learning resources and patient utilised software and hardware. The use of HoloLens as a disruptive technology is discussed as well as historical items as a feature in a modern medical curriculum. It concludes with a fascinating chapter on pulse extraction from facial videos. All in all, this volume has something for everyone whether that is faculty, students, clinicians and forensic practitioners, patients, or simply having an interest in one or more of these areas.
    Type of Medium: Online Resource
    Pages: XV, 202 p. 68 illus., 47 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030611255
    Series Statement: Advances in Experimental Medicine and Biology, 1317
    DDC: 610.72
    Language: English
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  • 47
    Keywords: Medicine Research. ; Biology Research. ; Veterinary medicine. ; Pharmacology. ; Biomedical Research. ; Veterinary Science. ; Pharmacology.
    Description / Table of Contents: The Endocannabinoid System and Endocannabinoidome -- The Pharmacology of Cannabinoids -- Toxicology -- Terpenes and Flavonoids: Cannabis Essential Oil -- Cannabinoids for Pain Management -- Cannabinoids for Neurological Conditions -- Well Being -- Cannabinoids for Gastrointestinal Health -- Dermatology: Endocannabinoids and Related N-Acylethanolamines in the Skin -- Cannabinoids in Oncology and Immune Response -- Nutritional Analysis of Cannabis -- Cannabinoid in Equine Medicine -- Product Selection and Dosing Considerations.
    Abstract: This book provides in-depth information on the applications of cannabis products as a legitimate medicine in treating a variety of diseases and disorders in domestic animals. Pharmacology and toxicology of cannabinoids and their effects on the endocannabinoid system, which is involved in the regulation of diverse physiological and cognitive processes, are discussed in detail. Furthermore, the book reviews development and testing of cannabis based medical products and introduces the nutritional components of cannabis plants. Cannabis as a therapeutic in veterinary medicine is gaining interest among owners and practitioners. Numerous studies have been completed or are currently underway that analyze the potential of clinical application of cannabinoid and terpenoid molecules. In this book the authors take a comprehensive look at previous studies in animal and human models and discuss translational applications based on these scientific data. This seminal text serves as a go-to resource for veterinary practitioners on cannabinoid therapy. It will also serve as a foundation for clinicians and researchers interested in this emerging field of veterinary medicine. .
    Type of Medium: Online Resource
    Pages: XVIII, 343 p. 26 illus., 22 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030683177
    DDC: 610.72
    Language: English
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  • 48
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Medical microbiology. ; Microbial populations. ; Cancer. ; Immunology. ; Biomedical Research. ; Medical Microbiology. ; Microbial Communities. ; Cancers. ; Immunology.
    Description / Table of Contents: Chapter 1_Significance of microbiome on human healthcare -- Chapter 2_Animal models for microbiome studies -- Chapter 3_Bioinformatics tools for analyzing microbiomes -- Chapter 4_Modulation of Systemic Immune Responses through genital, skin, and oral microbiota.-Chapter 5_Role of microbiome in development of immune system -- Chapter 6_Understanding the interplay between host immune-microbiome interactions -- Chapter 7_Overview on human gut microbiome and its role in immunomodulation -- Chapter 8_Cancer microbiome and immunotherapy: Understanding the complexity between microbes, immunity, and cancer -- Chapter 9_Dynamics of Respiratory Microbiome in lung dysbiosis -- Chapter 10_Microbiome Therapeutics: Emerging concepts and challenges -- Chapter 11_Intestinal Microbiome and Health -- Chapter 12_Macromolecule signalling mediating inflammation and immune system interaction -- Chapter 13_Microbiome-immune homeostasis and their involvement in cancer immunotherapy -- Chapter 14_Challenges and future prospects in the microbiome intervention in human health and disease.
    Abstract: The book provides an overview on how the microbiome contributes to human health and disease. The microbiome has also become a burgeoning field of research in medicine, agriculture & environment. The readers will obtain profound knowledge on the connection between intestinal microbiota and immune defense systems, medicine, agriculture & environment. The book may address several researchers, clinicians and scholars working in biomedicine, microbiology and immunology. The application of new technologies has no doubt revolutionized the research initiatives providing new insights into the dynamics of these complex microbial communities and their role in medicine, agriculture & environment shall be more emphasized. Drawing on broad range concepts of disciplines and model systems, this book primarily provides a conceptual framework for understanding these human-microbe, animal-microbe & plant-microbe, interactions while shedding critical light on the scientific challenges that lie ahead. Furthermore this book explains why microbiome research demands a creative and interdisciplinary thinking—the capacity to combine microbiology with human, animal and plant physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science. This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet in a typical immune system, and have contributed to animal and plant diversification over long evolutionary timescales. Also this book explains why microbiome research presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for human health and new strategies.
    Type of Medium: Online Resource
    Pages: XXIII, 296 p. 38 illus., 34 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811631566
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Biomedical Research.
    Description / Table of Contents: 1. Biobanking for Biomarker Discovery -- 2. Biobank design and infrastructure: Biobank Engineering -- 3. Biocomputing for biobanks: Workflow and information management systems for biobanks -- 4. Tissue Preservation and Factors Affecting Tissue Quality -- 5. The use of paraffin blocks/pathology archives for clinical biobanking -- 6. Biobanking Best Practices and Publication Standards -- 7. Ethical challenges for biobanks – two sides of the coin -- 8. Ten years of experience in training Biobank Managers at Master level in France.-9. National biobank networking: The case of Spain -- 10. Public-private Partnership in Biobanking: The Model of the BBMRI-ERIC Expert Centres.-11. The future of biobanking: meeting tomorrow’s challenges.-.
    Abstract: Over the past 25 years, biobanks of human specimens have become a cornerstone for research on human health and have empowered the “omics “revolution that characterizes biomedical science in the 21st Century. Today, biobanking of human specimens is a critical component of the interface between clinical practice and translational research, supporting the discovery and validation of new biomarkers of disease etiology, risk, early detection, diagnosis, prognosis, prediction and relapse. With the development of personalized medicine, biobanking of cryopreserved specimens has become standard practice in order to investigate genetic, transcriptomic, proteomic, metabolomics and immunological biomarkers useful to inform caregivers for therapeutic decisions.This book is the first comprehensive text on the market about human biobanking, and is a timely follow up to the editor’s 2017 volume Biobanking of Human Biospecimens: Principles and Practice. Written by leading scientists and regulatory officers in the field, the books can be read and used independently, but together, offer a deep understanding of all aspects of human biobanking as a central practice for research and medicine. The aim of the two volumes is to provide a published “one-stop shop” for state-of-the-art information on what constitutes the field of human biobanking, from conception of a biobank, standard operating procedures, ethical and societal aspects, governance, networking, interoperability and economic sustainability. This inclusive publication concept meets the needs of a vast readership, including scientists, doctors and technical staffs who are directly involved in biobanking operations, scientists in other disciplines that heavily rely on biobanking (such as genomics or proteomics), stakeholders and policy makers, and students for whom biobanking is becoming an important part of the training curriculum. .
    Type of Medium: Online Resource
    Pages: X, 206 p. 44 illus., 39 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030559014
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Biology Technique. ; Physiology. ; Evolution (Biology). ; Cytology. ; Vertebrates. ; Biomedical Research. ; Experimental Organisms. ; Animal Physiology. ; Evolutionary Biology. ; Cell Biology. ; Vertebrate Zoology.
    Description / Table of Contents: Dedication -- About the editors -- Preface (Jarvis JUM) -- Chapter 1. Social evolution in African mole-rats - a comparative overview (Faulkes CG & Bennett NC) -- Chapter 2. Social behavior in naked mole-rats: individual differences in phenotype and proximate mechanisms of mammalian eusociality (Holmes MM & Goldman BD) -- Chapter 3. Neuropeptidergic and neuroendocrine systems underlying eusociality and the concomitant social regulation of reproduction in naked mole-rats: a comparative approach (Coen CW, Bennett N, Holmes MM, & Faulkes CG) -- Chapter 4. Adult neural plasticity in naked mole-rats: implications of fossoriality, longevity and sociality on the brain’s capacity for change (Mooney SJ, Forger NG, & Holmes MM) -- Chapter 5. Sensory Systems of the African Naked Mole-Rat (Vice EN, Lagestee S, Browe BM, Deb D, Smith ESJ, Park TJ) -- Chapter 6. Hearing and vocalizations in the naked mole-rat (Barker AJ, Koch, U, Lewin GR, Pyott, SJ) -- Chapter 7. The somatosensory world of the African naked mole-rat (Lewin GR, Smith ESJ, Reznick J, Debus K, Barker A, and Park TJ) -- Chapter 8. The idiosyncratic physiological traits of the naked mole-rat; a resilient animal model of aging, longevity, and healthspan (Buffenstein R and Craft W) -- Chapter 9. African Naked Mole-Rats Demonstrate Extreme Tolerance to Hypoxia and Hypercapnia (Park TJ, Smith ESJ, Reznick J, Bennett NC, Applegate DT, Larson J, Lewin GR) -- Chapter 10. A sweet story of metabolic innovation in the naked mole-rat (Reznick J, Park TJ, and Lewin GR) -- Chapter 11. Insights into the molecular basis of genome stability and pristine proteostasis in naked mole-rats (Narayan V, McMahon M, O’Brien J, McAllister F and Buffenstein R) -- Chapter 12. The Unusual Immune System of the Naked Mole-Rat (Lin TD and Buffenstein R) -- Chapter 13 -- Induced Pluripotent Stem Cells from Cancer-Resistant Naked Mole-rats (Miura. K, Oiwa Y, and Kawamura Y) -- Chapter 14. Naked mole-rats: resistant to developing cancer or good at avoiding it? (Hadi F, Smith ESJ and Khaled WT) -- Chapter 15. Spontaneous Disease and Pathology of Naked Mole-rats (Delaney MA, Imai DM, Buffenstein R) -- Chapter 16. Managed Care of Naked Mole-rats (Smith M, and Buffenstein¬ R) -- Chapter 17. Some exciting future directions for work on naked mole-rats (Smith ESJ, ParkTJ, Holmes MM and Buffenstein R).
    Abstract: This volume focuses on the huge advances in the last 25 years on the use of this animal model for biomedical research (cancer, heart disease and neurodegeneration), fundamental neuroscience and basic subterranean biology. In 2013, Science magazine named the naked mole-rat as the Vertebrate of the Year. This was partly due to research carried out documenting its extreme longevity, negligible senescence, and prolonged maintenance of cancer free, good health well into old age as well as seminal work on mechanisms involved in these processes, pain and hypoxia resistance. In addition to this research focus on longevity and chronic diseases such as cancer and cardiovascular disease, the naked mole-rat has also made a substantial contribution to the fields of ecophysiology, neuroscience and behavior. With international contributions, this book provides a valuable text for zoological students, behavioral scientists and biomedical researchers.
    Type of Medium: Online Resource
    Pages: XIV, 445 p. 188 illus., 139 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030659431
    Series Statement: Advances in Experimental Medicine and Biology, 1319
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Clinical biochemistry. ; Biomedical Research. ; Medical Biochemistry.
    Description / Table of Contents: 1. Molecular Pharmacology of the Youngest Member of the Nuclear Receptor Family: The Mineralocorticoid Receptor -- 2. A Simple Method for Visual Assessment and Quantification of Altered Subcellular Localization of Nuclear Receptors -- 3. Multifaceted Effects of Ligand on Nuclear Receptor Mobility -- 4. Chemical Considerations in Discovery of Receptor Modulators -- 5. Structure-Based Design of Estrogen-Related Receptors Modulators -- 6. PPARα and δ ligand design – Honing the traditional empirical method with a more holistic overview -- 7. Pregnane X Receptor: understanding its function and activity at the molecular level -- 8. Ligand Design for the Vitamin D Receptor -- 9. What Makes a Good Antagonist: Lessons Learned from the Estrogen and Aryl Hydrocarbon Receptors -- 10. Design of Novel PPAR agonist for Neurodegenerative Disease -- 11. Functional bioassays lithograph ligand reflections in the PPARalpha sphere -- 12. Computational applications on Food Contact Chemicals as Nuclear Receptors binders -- 13. Alternation of Nuclear Hormone Receptor Signaling by Antiviral Drugs -- 14. Retinoic acid-related orphan receptor (ROR) inverse agonists: potential therapeutic strategies for multiple inflammatory diseases -- 15. Therapeutic Strategies to Target Activating Estrogen Receptor a Mutation -- 16. Androgen Receptors in the Pathology of Disease -- 17. Bilirubin: A Ligand of the PPARα Nuclear Receptor -- 18. Nuclear Receptor Ligands in Flavivirus Infection Control -- 19. Use of Nanotechnology to Improve 15d-PGJ2 Immunomodulatory Activities -- 20.Ligand-independent Activation of PPARs -- 21. PPAR Modulation Through Posttranslational Modification Control -- 22. Developing Inhibitors to the Amino-Terminus Domains of Steroid Hormone Receptors -- 23. Redirecting the cellular waste disposal machinery to target transcription.
    Abstract: Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.
    Type of Medium: Online Resource
    Pages: XI, 679 p. 209 illus., 127 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030783150
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Dentistry. ; Biomineralization. ; Biomaterials. ; Bones. ; Physiology. ; Biomedical Research. ; Dentistry. ; Biomineralization. ; Bone Physiology.
    Description / Table of Contents: Part 1: Extracellular matrix molecules of mineralized structures -- Chapter 1: Collagen-derived mineralized structures (dentin, cementum, bone and cartilage) and non-collagenous ECM of enamel -- Chapter 2: ECM- nomenclature and functions -- Part 2: Collagen-derived extracellular matrix components: dentin, bone and cementum -- Chapter 3: Collagenous mineralized tissues: composition, structure, biomineralization -- Chapter 4: Non-collagenous ECM matrix components. Growth factors & cytokines involved in matrix mineralization -- Chapter 5: Odontoblast processes: new insights into its role in dentin mineralization -- Chapter 6: Small leucine rich proteoglycans (SLRPs) and Biomineralization -- Chapter 7: Cementum proteins beyond cementum -- Chapter 8: Biochemistry of non-collagenous proteins of bone -- Part 3: Enamel -- Chapter 9: Human tooth enamel, a sophisticated material -- Chapter 10: Proteinases in enamel development -- Chapter 11: Enamel matrix biomineralization- the role of pH cycling -- Chapter 12: Environmental factors and enamel/dentin defects.
    Abstract: This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs). The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the matrix components (non-collagenous) of enamel (amelogenin, ameloblastin, enamelin, MMP4, MMP20 and other proteases) are reviewed and their respective roles in dental tissues biomineralizations and tissue turnover are discussed. Additionally, environmental factors involved in enamel / dentin defects are adressed. With state-of-the-art contributions from experts in the respective domains, the book is a useful introduction to the field for junior scientists, interested in dental and peridental tissue biomineralization. It is also an interesting read for advanced scientists and clinicians working in dental research, giving them a broader view of the topic beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
    Type of Medium: Online Resource
    Pages: VIII, 305 p. 64 illus., 41 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030762834
    Series Statement: Biology of Extracellular Matrix, 10
    DDC: 610.72
    Language: English
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    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Solar system. ; Aerospace engineering. ; Astronautics. ; Biomedical Research. ; Cell Biology. ; Space Physics. ; Aerospace Technology and Astronautics.
    Description / Table of Contents: Chapter 1. Introduction: Space Life Sciences – Basic Research and Applications under Extraordinary Conditions -- Chapter 2. A Long Way for Europe and Germany: From Apollo 16 to the International Space Station ISS -- Chapter 3. Success Stories: Incremental Progress and Scientific Breakthroughs in Life Science Research -- Chapter 4. Success Stories: Innovative Developments for Biomedical Diagnostics and Preventative Health Care -- Chapter 5. Space Life Sciences in the Exploration Era: An Outlook on Future Challenges and Opportunities.-.
    Abstract: This last volume of the SpringerBriefs in Space Life Sciences series is setup in 5 main parts. The 1st part shortly summarizes the history of life science research in space from the late 40s until today with focus on Europe and Germany, followed by a part on describing flight opportunities including the Space Shuttle/Spacelab system and the International Space Station ISS; in the 3rd part it focuses on extraordinary success stories of this constantly challenging research program and highlights some important key findings in space life science research. The book introduces in the 4th part innovative developments in non-invasive biomedical diagnostics and training methods for astronauts that emerge from this program and are of benefit for people on Earth especially in the aging society. Last but not least in its 5th part it closes with an outlook on the future of space life sciences in the upcoming era of space exploration. The book is intended for students and research scientists in the life sciences and biomedicine as well as for interested lay persons, who wish to get an overview of space life science research: its´ early days, current status and future directions.
    Type of Medium: Online Resource
    Pages: XVII, 155 p. 34 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030740221
    Series Statement: SpringerBriefs in Space Life Sciences,
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Internal medicine. ; Biomedical Research. ; Pharmacology. ; Internal Medicine.
    Description / Table of Contents: Chapter 1. Discovery and Concept of Endemic Fluorosis -- Chapter 2. Epidemic Status of Coal-burning Type of Endemic Fluorosis -- Chapter 3. Skeletal Fluorosis -- Chapter 4. Medical Imaging Manifestation of Skeletal Fluorosis -- Chapter 5. Epidemic characteristic and pathogenesis of dental fluorosis -- Chapter 6. Damage in Nervous System -- Chapter 7. Modification of Digestive System -- Chapter 8. Modification of Urinary System -- Chapter 9. Modification of Cardio-Vascular System -- Chapter 10.Damage of Endocrine System -- Chapter 11. Damages to Reproductive System by Coal-burning Type of Endemic Fluorosis -- Chapter 12. Enhanced Oxidative Stress -- Chapter 13. High Level of Inflammation -- Chapter 14. Effect of Fluoride on Signal Transduction Pathways -- Chapter 15. Changes of Receptors -- Chapter 16. Alteration of Endoplasmic Reticulum Stress -- Chapter 17. Mitochondrial Changes -- Chapter 18. Calcium Metabolism Disorder in Chronic fluorosis -- Chapter 19. Altering of Carbohydrate Metabolism -- Chapter 20. Changes in Gene Expression -- Chapter 21. Biological Indicators for Early Diagnosis of Endemic Fluorosis -- Chapter 22. Comprehensive Prevention and Control of Coal-burning Type of Endemic Fluorosis -- Chapter 23. Surgical Treatment of Joint Damage in Skeletal Fluorosis -- Chapter 24. Clinical Treatment of Dental Fluorosis -- Chapter 25. Drug Development -- Chapter 26. Improvement of Health Condition of the Residents in the Areas of Coal-burning Type of Endemic Fluorosis after Comprehensive Treatments.
    Abstract: Endemic fluorosis is caused by excessive intake of fluorine in drinking water, air, food, tea and other media in a specific natural environment for a long time, which involves at least 25 countries, such as China, India, Vietnam, Iran, Egypt, Mexico, Argentina and influences more than 200 million of population. China and India are the countries with the most extensive endemic fluorosis and the most serious damages. There are three main intake sources of endemic fluorosis, e.g., drinking water, coal-burning pollution and drinking tea. Coal-burning type of endemic fluorosis was established in Guizhou Province of China in 1970’s. The residents in the areas used indoor stoves with no flue to burn coals with high content of fluoride to bake grains in the autumn and heat in the winter. This results in excessive intake of fluorine and then leads chronic poisoning. It has been confirmed that 13 provinces of China with 34.3 million of population are influenced by this type of fluorosis with severe injuries to most organs of human body. The content of this book covers the epidemiology, pathological changes, molecular pathogenesis and clinical treatments of the disease. This book is a suitable reference for the researchers and graduate students in this field, which is helpful to improve the understanding of this disease and to take preventive measures.
    Type of Medium: Online Resource
    Pages: XVI, 465 p. 23 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811614989
    DDC: 610.72
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Medicine Research. ; Biology Research. ; Medical jurisprudence. ; Biomaterials. ; Nucleic acids. ; Biomedical Research. ; Forensic Medicine. ; Nucleic Acid.
    Description / Table of Contents: 1 Initial response at crime scenes and prioritization of efforts -- 2 Crime scene processing: documentation and evaluation -- 3 Crime Scene Searching: An Exploration of Forensic Evidence -- 4 Collection, Preservation and Packaging: Forensic Evidence Management -- 5 Paint, Soil and Glass Evidences: A Silent Witnesses -- 6 Questioned Document Examination: A Prevalent Dispute -- 7 Medicolegal Examination: A Guide to the Criminal Investigation System -- 8 Examination of Tampered Voice. .
    Abstract: This book provides deep insight into the significance of various forensic techniques underlying the methodical approaches in criminal investigations. The book comprises numerous case studies, examples, and reference materials. It emphasizes on the better practices for criminal investigations including contemporary examinations. The book also describes various methods for investigation of crime scene and evidence collection including biological evidences to the resources of law enforcement agencies. This book encompasses the procedure for crime scene-documentation through photography, video, and diagrams and highlights the best practices of packaging the biological evidences at a crime scene. Further, it summarizes the role of forensic autopsy to the criminal investigation system. As such, the book is helpful for forensic scientists, medical practitioners, educators and law enforcement personnel.
    Type of Medium: Online Resource
    Pages: V, 239 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789811640919
    DDC: 610.72
    Language: English
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    Keywords: Water. ; Hydrology. ; Environment. ; Pollution. ; Water. ; Environmental Sciences. ; Pollution.
    Description / Table of Contents: Introduction -- Water Security Assessment for the Red – Thai Binh River Basin, Vietnam -- Contextualizing Farmers’ Perceptions of Agricultural Wastewater Reuse in Areas of Water Shortage and Contamination: An In-depth Case Study of Wadi Al-Far`a Watershed – Palestine -- Optimize Anaerobic Degradation Processes in Agricultural Wastewater Treatment to maximize Biogas Productivity -- Evaluation of Wastewater Treatment using Dilution in Rosetta Branch and Tala Drain, Nile Delta, Egypt -- Upcoming Challenges of Water Reclamation fromUnconventional Sources -- How Membrane Bioreactor Technology Can Help to Solve both, German and RussianWastewater Problems -- Experiences on Wastewater Treatment and Reuse for Different Types of Industries -- Social Characteristics and Adaptation to Water Scarcity: The Case of Groundnut Farmers in the Lawra and Nandom Districts, Ghana -- Temporal Climate Variability and Staple Cereals in Southern Burkina Faso.
    Abstract: This book describes the water security challenges with focus on water scarcity and quality in our rapidly changing world. Achieving water security is essential to promoting economic and social development, as well as resource sustainability and ecosystem integrity. Questions of water security are central to recent global agreements such as the Sustainable Development Goals (SDGs), the Paris Agreement on Climate Change, and the Sendai Framework for Disaster Risk Reduction. The thematic areas discussed here support the SDGs, with special attention to Goal 6 (“Ensure availability and sustainable management of water and sanitation”). The book is a collection of studies from engineering, social and environmental disciplines and aims at giving a balanced overview of the current , complex discourse on water scarcity and quality. It offers a source of inspiration and information for researchers, policymakers, planners, and practitioners concerning the further development of concepts, approaches, and methodologies for promoting water secure societies.
    Type of Medium: Online Resource
    Pages: XIII, 200 p. 90 illus., 68 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030506537
    DDC: 551.48
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Environmental management. ; Pollution. ; Earth sciences. ; Environment. ; Water. ; Environmental Management. ; Pollution. ; Earth Sciences. ; Environmental Sciences.
    Description / Table of Contents: Part I: Introduction -- Chapter 1. The Emergence of Water Resilience: an introduction -- Part II: Examining water systems through the lens of resilience -- Chapter 2. Water Policy and Governance in Transition: The EU Water Framework Directive -- Chapter 3. The Sustainable Groundwater Management Act (SGMA)—California’s Prescription for Common Challenges of Groundwater Governance -- Chapter 4. Water Policy Reform for Sustainable Development in the Murray-Darling Basin, Australia: Insights from Resilience Thinking -- Chapter 5. Reducing Nutrient Loading from Agriculture to Lake Ecosystems – Contributions of Resilience Principles -- Chapter 6. Reconfiguring water governance for resilient social-ecological systems in South America -- Part III: Exploring the conceptual boundaries and bridges of water resilience -- Chapter 7. Capacities for watershed resilience: persistence, adaptation, and transformation -- Chapter 8. Adaptive Governance in North American Water Systems: a legal perspective on resilience and reconciliation -- Chapter 9. Cross-scale Governance for Urban Water Resilience in Bengaluru and Cape Town -- Chapter 10. Facing Change: Understanding Transitions of River Basin Policies Over Time -- Chapter 11. Conditions and Cautions for Transforming Ocean Governance -- Chapter 12. Extraordinary governance to avoid extraordinary events. Part IV: Conclusion -- Chapter 13. Charting a course for management and governance dimensions of water resilience.
    Abstract: This book synthesizes current knowledge and understanding of management and governance in the context of water resilience; advances theory through synthesis of research and experiences from a variety of disciplinary perspectives. The book highlights the implications of theory and experience for innovation in practice and policy; and it explores frontiers and future research. The book further addresses the need for a consolidated, interdisciplinary approach to the theoretical advances and practical implications of water resilience for academics, resource managers, aid organizations, policy makers and citizens. .
    Type of Medium: Online Resource
    Pages: X, 311 p. 23 illus., 18 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030481100
    DDC: 551.48
    Language: English
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    Keywords: Water. ; Hydrology. ; Climatology. ; Geotechnical engineering. ; Water. ; Climate Sciences. ; Geotechnical Engineering and Applied Earth Sciences.
    Description / Table of Contents: Water Quality Challenges in Ganga River Basin, India -- Sequential Characterization of Contaminant Plumes using feedback information -- Evaluation of groundwater quality using Multivariate analysis: Rae Bareli District, Ganga Basin, Uttar Pradesh -- A Supervising Grid Model for Identification of Groundwater Pollute -- Study of Methods available for Groundwater and Surfacewater Interaction: A case study on Varanasi, India -- Augmentation of Drinking Water Supply by River Bank Filtration -- River Discharge Study in River Ganga, Varanasi Using Conventional and Modern Techniques -- Review on the Field Applications of River Training Structures for River Bank Protection -- Comparison of conceptual and distributed hydrological Models for runoff Estimation in a River Basin -- Monthly variation in near surface air temperature lapse rate across Ganga Basin, India -- Identification of relationship between precipitation and atmospheric oscillations in Upper Ganga basin -- Utilizing stream networks for regional flood frequency analysis -- Plotting Positions for the Generalized Extreme Value Distribution: A Critique -- Application of Machine Learning Techniques for Clustering of Rainfall Time Series Over Ganges River Basin.
    Abstract: This book presents an overview of the hydrometeorological and hydrological studies and assists in tackling challenges posed by climate and land use land cover changes. The Ganga River is one of the major living streams on the planet earth and very important river system in India. This holy river is a lifeline for approximately five hundred million people. In the last few decades, River Ganges has been subjected to tremendous pressures with respect to both water quantity and water quality. This situation, already one of the alarming magnitudes, has been further provoked by hydrometeorological changes resulting in droughts, floods and reduced groundwater levels and river flows in addition to the poor river health. Thus, it is imperative to assess the various complexities and possible solutions for better management of River Ganges. This book is a valuable addition to the literature and contributes to research on River Ganges which will help better planning and management of Ganga river basin. The hydrological and hydrometeorological aspects covered in this book help practitioners, researchers, policymakers and other stakeholders.
    Type of Medium: Online Resource
    Pages: XVI, 322 p. 119 illus., 45 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030608699
    Series Statement: Society of Earth Scientists Series,
    DDC: 551.48
    Language: English
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    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Water. ; Hydrology. ; Mathematical optimization. ; Quantitative research. ; Artificial intelligence Data processing. ; Water. ; Optimization. ; Data Analysis and Big Data. ; Data Science.
    Description / Table of Contents: Modelling and Simulation -- Optimization -- Big data and Databases -- Data mining -- Remote sensing -- Geographical information system -- System dynamics -- Agent-based models -- Game theory -- Conflicts resolution -- Multi-objective optimization -- Multicriteria and multi-attribute decision -- making -- Risk, uncertainty, and reliability.
    Abstract: This book describes tools needed in water resources management, using methods such as optimization algorithms, conflict resolution methods, risk and uncertainty analysis, to better manage water resources and consumption, thus mitigating the present and future global water shortage crisis. It presents the applications of these tools through case studies which demonstrate its benefits of proper management of water resources. This book acts as a reference for students, professors, industrial practitioners and stakeholders in the field of water resources management and hydrology.
    Type of Medium: Online Resource
    Pages: VI, 343 p. 78 illus., 35 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813342958
    Series Statement: Springer Water,
    DDC: 551.48
    Language: English
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    Keywords: Water. ; Hydrology. ; Pollution. ; Chemical engineering. ; Water. ; Pollution. ; Chemical Engineering.
    Description / Table of Contents: Preface -- Chapter 1 Fundamentals of Adsorption -- Chapter 2 Methods of Synthesis of Magnetic Adsorbents -- Chapter 3 Magnetic Biosorbents and their Application in Water Remediation -- Chapter 4 Lignocellulosic Wastes as Precursor of carbonaceous magnetic adsorbents of organic and inorganic pollutants adsorption -- Chapter 5 Magnetic Biochar Fibers for Copper Removal -- Chapter 6 Treatment of Landfill Leachate with Magnetic Adsorbents -- Chapter 7 Removal of Emerging Pollutants and Toxic Metals using Magnetic Adsorbents -- Chapter 8 Magnetically Modified Biological Materials for Dyes Removal -- Chapter 9 Regeneration of magnetic adsorbents saturated by organic pollutants using advanced oxidation technologies -- Chapter 10 Magnetic Nanofibers for Contaminants Removal from Water -- Chapter 11 Magnetic solid phase-based sorbents for isolation/pre-concentration and removal of pesticides -- Chapter 12 Characterization and application of Fe-magnetic materials and nanomaterials for application in the aqueous matrices decontamination -- Chapter 13 Advanced Magnetic Adsorbents Prepared from Emulsion Template for Water Treatment -- Chapter 14 Chitosan Based Magnetic Adsorbents -- Chapter 15 Methods used for performance enhancement of iron based magnetic adsorbents in water systems.
    Abstract: This book compiles 15 chapters about the synthesis, characterizations, and application of many kinds of magnetic adsorbents for water treatment. It is devoted to the scientific community that works with adsorption technologies for water treatment and remediation. Specifically, for professors and Ph.D. students. It is expected that this book serves as an interesting background for researchers in the field of magnetic adsorbents for water treatment.
    Type of Medium: Online Resource
    Pages: XVI, 501 p. 117 illus., 78 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030640927
    Series Statement: Environmental Chemistry for a Sustainable World, 61
    DDC: 551.48
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Artificial intelligence. ; Environmental sciences Mathematics. ; Environment. ; Neural networks (Computer science) . ; Human ecology Study and teaching. ; Water. ; Artificial Intelligence. ; Mathematical Applications in Environmental Science. ; Environmental Sciences. ; Mathematical Models of Cognitive Processes and Neural Networks. ; Environmental Studies.
    Description / Table of Contents: Introduction -- Mathematical Background -- Data Preprocessing -- Neural Network -- Training a Neural Network -- Updating Weights -- Improving model performance -- Advanced Neural Network Algorithms -- Deep learning for time series -- Deep learning for spatial datasets -- Tensorflow and Keras Programming for Deep Learning -- Hydrometeorological Applications of deep learning -- Environmental Applications of deep learning.
    Abstract: This book provides a step-by-step methodology and derivation of deep learning algorithms as Long Short-Term Memory (LSTM) and Convolution Neural Network (CNN), especially for estimating parameters, with back-propagation as well as examples with real datasets of hydrometeorology (e.g. streamflow and temperature) and environmental science (e.g. water quality). Deep learning is known as part of machine learning methodology based on the artificial neural network. Increasing data availability and computing power enhance applications of deep learning to hydrometeorological and environmental fields. However, books that specifically focus on applications to these fields are limited. Most of deep learning books demonstrate theoretical backgrounds and mathematics. However, examples with real data and step-by-step explanations to understand the algorithms in hydrometeorology and environmental science are very rare. This book focuses on the explanation of deep learning techniques and their applications to hydrometeorological and environmental studies with real hydrological and environmental data. This book covers the major deep learning algorithms as Long Short-Term Memory (LSTM) and Convolution Neural Network (CNN) as well as the conventional artificial neural network model.
    Type of Medium: Online Resource
    Pages: XIV, 204 p. 189 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030647773
    Series Statement: Water Science and Technology Library, 99
    DDC: 551.48
    Language: English
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  • 62
    Keywords: Water. ; Hydrology. ; Pollution. ; Bioclimatology. ; Environmental monitoring. ; Geographic information systems. ; Water. ; Pollution. ; Climate Change Ecology. ; Environmental Monitoring. ; Geographical Information System.
    Description / Table of Contents: Chapter 1: Hydrologic Model for Runoff Simulation of the Kyzyl-Suu River -- Chapter 2: Integrated Water Resources and Environmental Management in the Transboundary Rivers Basins of Central Asia -- Chapter 3: Experience of Preparation of River Basin Planning and Management on Water Resource Development, Use and Protection in Main and Minor Transboundary River Basins -- Chapter 4: Assessment of Amu Darya Runoff Changes as a Result of Predicted Climate Change and Reduced Glaciation -- Chapter 5: Climate Change Forecast in Kyrgyzstan for 2050 and 2100 -- Chapter 6: Reactions and Dynamics of Drains on Small Transboundary Rivers with Various Feeding Types and the Effect on Climate Change -- Chapter 7: Assessment of anthropogenic loads on the Talas River Watershed (within the Republic of Kazakhstan) -- Chapter 8:The Glacial Systems of Kyrgyzstan under Climate Change -- Chapter 9: Water Resource Risks to Cotton Agriculture in Uzbekistan: Climate, Policy and Irrigation -- Chapter 10: Groundwater Flooding Risk Assessment Using Microseismic Arrays and VES Techniques in the Northern Part of Bishkek -- Chapter 11: Designing Sustainable Futures: Interdisciplinary Science and Social Creativity -- Chapter 12: Water Reuse for Irrigation in Rural Areas in Japan: Implications/Insights for Central Asia and Afghanistan -- Chapter 13: Physics-Chemical Properties of the Kyzyl-Suu River and its tributaries -- Chapter 14: Environmental and Water Resources Management Study of Ghorband-Panjshir and Kunduz Rivers Basins, Afghanistan -- Chapter 15: Investigation of the High Mountain Vegetation Using Satellite Imagery, Kyrgyzstan -- Chapter 16: New Approaches and Advanced Methodology in Integrated Water Resources Management: Amu Darya River Basin -- Chapter 17: Investigation of the Various Aspects of the Kafirnigan River Basin, Tajikistan. .
    Abstract: The book provides a cross-sectoral, multi-scale assessment of development-directed investigations in the main rivers of wider Central Asia and Afghanistan. The book highlights the development of river systems, water reservoirs, ecosystems and risks as well as the impact of climate change on water resources in Central Asian countries and Afghanistan. It provides information on the genesis of river basins, physical and chemical properties of water in rivers, and the hydrological regimes of the rivers of Central Asia and Afghanistan. The book is useful for scientists and researchers whose work focuses on rivers and the use of water resources, irrigation, ecosystems, risks, water supply, climate change and remote sensing, as well as for students and planners, administrations and other stakeholders in the water sector.
    Type of Medium: Online Resource
    Pages: VII, 193 p. 91 illus., 77 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030683375
    Series Statement: Springer Water,
    DDC: 551.48
    Language: English
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  • 63
    Keywords: Water. ; Hydrology. ; Food security. ; Natural disasters. ; Environmental monitoring. ; Sustainability. ; Water. ; Food Security. ; Natural Hazards. ; Environmental Monitoring. ; Sustainability.
    Description / Table of Contents: Intelligent Irrigation Water Management -- River Hydraulics -- Assessment and Monitoring of Hydrological Extremes -- Future Scenarios.
    Abstract: This book presents quality technical papers representing the recent developments in the field of hydrological modeling, water management and water governance including practical applications. The content covers multifarious aspects of hydrology and water resources. It includes an application of the Hydrologic Modelling System (HEC-HMS) which has been successfully demonstrated for assessment of floods. The authors suggest an approach for the mitigation of cyclone disaster through a case study of the Phailin cyclone, whilst considering mitigating pluvial flooding, developing suitable management strategies. The book includes chapters discussing the detrended fluctuation analysis which is carried out for multifractal description of droughts. Drought characteristics are analyzed, and drought indices evolved for drought preparedness/management. The use of science in community planning under changing climate is also studied and discussed. The authors present and experimental study wherein hydraulic coefficients are calibrated by using vertical orifice. A cross flow hybrid hydrokinetic turbine is also evaluated for performance, and high head regulating radial gate designed and studied its sensitivity. This book will appeal to researchers, field practitioners, NGO and other Governmental as well as private water practitioners .
    Type of Medium: Online Resource
    Pages: XII, 446 p. 262 illus., 230 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030591489
    Series Statement: Water Science and Technology Library, 97
    DDC: 551.48
    Language: English
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  • 64
    Keywords: Water. ; Hydrology. ; Geographic information systems. ; Ecology Methodology. ; Environmental sciences Social aspects. ; Water. ; Geographical Information System. ; Ecological Modelling. ; Environmental Social Sciences.
    Description / Table of Contents: 1. Application of RS and GIS in Watershed Management -- 2. Application of RS and GIS in Agricultural Water Management -- 3. Hydrological Modeling -- 4. Intelligent Water Management -- 5. Water Governance.
    Abstract: This book focusses on hydrological modeling, water management, and water governance. It covers the applications of remote sensing and GIS tools and techniques for land use and land cover classifications, estimation of precipitation, evaluation of morphological changes, and monitoring of soil moisture variability. Moreover, remote sensing and GIS techniques have been applied for crop mapping to assess cropping patterns, computation of reference crop evapotranspiration, and crop coefficient. Hydrological modeling studies have been carried out to address various issues in the water sector. MODFLOW model was successfully applied for groundwater modeling and groundwater recharge estimation. Runoff modeling has been carried out to simulate the snowmelt runoff together with the rainfall and sub-surface flow contributions for snow-fed basins. A study has been included, which predicts the impact of the land use and land cover on stream flow. Various problems in the water sector have been addressed employing hydrological models such as SWAT, ArcSWAT, and VIC. An experimental study has been presented wherein the laboratory performance of rainfall simulator has been evaluated. Hydrological modeling studies involving modifications in the curve number methodology for simulation of floods and sediment load have also been presented. This book is useful for academicians, water practitioners, scientists, water managers, environmentalists, and administrators, NGOs, researchers, and students who are involved in water management with the focus on hydrological modeling, water management, and water governance.. .
    Type of Medium: Online Resource
    Pages: XI, 550 p. 265 illus., 231 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030580513
    Series Statement: Water Science and Technology Library, 96
    DDC: 551.48
    Language: English
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  • 65
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Pollution. ; Environmental policy. ; Sociology. ; Environmental economics. ; Water. ; Pollution. ; Environmental Policy. ; Sociology. ; Environmental Economics.
    Description / Table of Contents: Chapter1: The circular economy of water (CEW) -- Chapter2: Water treatment: pollution removal mechanisms in the rainwater harvesting process -- Chapter3: Supply & demand: multiple waters for multiple purposes and multiple uses -- Chapter4: The components of a rainwater harvesting system: modular, standardised, plug and play -- Chapter5: Climate resilient RWH: a technological portfolio -- Chapter6: Rainwater harvesting design -- Chapter7: The economics of rainwater harvesting -- Chapter8: Rainwater harvesting and the sustainable development goals (SDG's).
    Abstract: There is no more fundamental substance to life on earth than water. Ninety nine percent of all human molecules are water molecules. Three quarter of the earth’s surface is covered by either saltwater or freshwater, yet millions face a daily struggle to access enough water for survival. The effects of ongoing climate change have expanded the water crisis to areas previously considered water secure. This book addresses the role rainwater harvesting (rwh) can play in developing a resilient water infrastructure that will prove adaptive to climate change and its implications. The book features three sections. The first section presents the concepts underpinning a new approach to water infrastructure. The term “the worth of water” was developed to reflect the importance of the social life of water. This encompasses all human relationships with water including the social, cultural, hydrological, political, economic, technical and spiritual. A technology portfolio showcasing the worth of water from the qanats of the ancient world to the modern rain cities is presented. Other concepts discussed include the circular economy of water and the concept of multiple waters for multiple users of multiple qualities. Water and its properties are a function of its peculiar molecular structure and this is illustrated in the book. Rainwater harvesting is considered by the authors as containing an inherent treatment train which functions as a complex water treatment system. The physical, chemical and biological removal mechanisms that form an inherent part of the rwh system are discussed. Part two presents a new rwh design methodology together with design templates and worked examples for the hydraulic and economic analysis of rwh systems. A state-of-the-art literature review of the potential health implications of utilizing rwh is also presented. The final section of the book discusses how rwh can play a vital role in contributing to achieving the sustainable development goals and to living within the planetary boundaries.
    Type of Medium: Online Resource
    Pages: XXIV, 206 p. 199 illus., 193 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030506056
    DDC: 551.48
    Language: English
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  • 66
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Environmental management. ; Political science. ; Political planning. ; Environmental sciences Social aspects. ; Water. ; Environmental Management. ; Governance and Government. ; Public Policy. ; Environmental Social Sciences.
    Description / Table of Contents: Chapter 1. Introduction: The Realities of Adaptive Management -- Chapter 2. The Natural Physical System of Chino Basin -- Chapter 3. The Development of Water Supplies and Water Conservation in Chino Basin -- Chapter 4. Upstream-Downstream Conflicts, 1930-1960 -- Chapter 5. Setting the Stage for a Chino Basin Management Program: Changes in Water Use, and the Third Santa Ana River Litigation, 1960-1969 -- Chapter 6. The Chino Basin Adjudication -- Chapter 7. The Governance Structure for Chino Basin under the Judgment -- Chapter 8. Water Management in the Basin during the First 20 Years under the Judgment -- Chapter 9. Turbulence: The 1990s in Chino Basin -- Chapter 10. Reconstituting Chino Basin Governance and Management -- Chapter 11. Adapting to Social and Economic Change -- Chapter 12. Adapting to and with the Neighbors -- Chapter 13. Adapting to the Changing Realities of Water Supply -- Chapter 14. Adapting to Water Quality Problems and Priorities -- Chapter 15. Resetting the Safe Yield and Reappointing the Watermaster -- Chapter 16. Looking Ahead: The Reality of Continual Adaptation -- Chapter 17. Lessons from Chino Basin for Adaptive Groundwater Management [note: includes section on California’s Sustainable Groundwater Management Act (SGMA)].
    Abstract: This book has three primary objectives. The first objective is to provide scholars with a more realistic view of adaptive management, without arguing against adaptive management. Adaptive management is necessary as well as desirable, but it is not easy, and demonstrating that through the Chino Basin experience is an important goal. The second objective is to provide practitioners with encouraging yet cautionary lessons about the challenges and benefits of an adaptive approach – in similar fashion as the first objective, the goal here is to endorse the adaptive approach but in a clear-eyed manner that clarifies how hard it is and how much it requires. A third objective is to show all audiences that resource governance systems can fail, change, and succeed. There is no such thing as an ideal institutional design that is guaranteed to work; rather, making institutional arrangements work entails learning and adjustment when they begin to show problems as they inevitably will. .
    Type of Medium: Online Resource
    Pages: XX, 288 p. 19 illus., 15 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030637231
    Series Statement: Global Issues in Water Policy, 27
    DDC: 551.48
    Language: English
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  • 67
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Biogeography. ; Microbiology. ; Freshwater ecology. ; Marine ecology. ; Water. ; Biogeosciences. ; Microbiology. ; Freshwater and Marine Ecology.
    Description / Table of Contents: Chapter1: Nitrogen Fixation in the Marine Environment -- Chapter2: Fundamentals of N2 Fixation -- Chapter3: History of Research on Marine N2 Fixation -- Chapter4: Microorganisms and Habitats -- Chapter5: Measurements of Organism Abundances and Activities -- Chapter6: Factors Controlling N2 Fixation -- Chapter7: Biogeography of N2 Fixation in the Surface Ocean -- Chapter8: N2 Fixation in Ocean Basins -- Chapter9: Marine N2 Fixation, Global Change and the Future -- Chapter10: Summary and Conclusions.
    Abstract: This book aims to serve as a centralized reference document for students and researchers interested in aspects of marine nitrogen fixation. Although nitrogen is a critical element in both terrestrial and aquatic productivity, and nitrogen fixation is a key process that balances losses due to denitrification in both environments, most resources on the subject focuses on the biochemistry and microbiology of such processes and the organisms involved in the terrestrial environment on symbiosis in terrestrial systems, or on largely ecological aspects in the marine environment. This book is intended to provide an overview of N2 fixation research for marine researchers, while providing a reference on marine research for researchers in other fields, including terrestrial N2 fixation. This book bridges this knowledge gap for both specialists and non-experts, and provides an in-depth overview of the important aspects of nitrogen fixation as it relates to the marine environment. This resource will be useful for researchers in the specialized field, but also useful for scientists in other disciplines who are interested in the topic. It would provide a possible text for upper division classes or graduate seminars.
    Type of Medium: Online Resource
    Pages: XV, 186 p. 36 illus., 31 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030677466
    DDC: 551.48
    Language: English
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    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Water. ; Hydrology. ; Environmental chemistry. ; Environment. ; Water. ; Environmental Chemistry. ; Environmental Sciences.
    Description / Table of Contents: Heavy Metals - An Overview -- Coral Reef Ecosystems -- The Use of Scleractinian Corals for Heavy Metal Studies -- Analytical Techniques Used for Heavy Metal Analysis in Corals.
    Abstract: This book provides an in-depth review of heavy metals in corals, describing the sources of heavy metals in the marine environment and their effect on corals. It is designed to serve as a unique reference for upcoming marine researchers and chemists, advanced undergraduate and postgraduate students as well as those interested in marine pollution with respect to heavy metals. The book explains the basics as well as the state-of-the-art regarding heavy metals and corals and is engaging and clearly written and narrated, providing readers with the fundamental tools about the subject matter that they need in their specific fields. It allows readers to understand and appreciate the interactions between the atmosphere, ocean, and the geosphere. Detailed reference is included for the benefit of the reader. The specific objectives of this book are (i) to inform/educate the reader about persistent pollutants such as heavy metals, (ii) to identify sources of heavy metals in the marine environment, (iii) to inform about route of exposure and uptake of the heavy metal pollutants by corals, (iv) to elaborate about the effect of heavy metal pollutants on the coral reef ecosystems, (v) to discuss the ways in which heavy metal regulation occurs in corals, (vi) to impact current knowledge regarding heavy metals in the marine environment, and (vii) to briefly show chemical analysis and instrumentation for analyzing heavy metals.
    Type of Medium: Online Resource
    Pages: X, 90 p. 1 illus. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030736132
    Series Statement: SpringerBriefs in Earth Sciences,
    DDC: 551.48
    Language: English
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  • 69
    Keywords: Water. ; Hydrology. ; Physical geography. ; Natural disasters. ; Water. ; Earth System Sciences. ; Natural Hazards.
    Description / Table of Contents: 1. Introduction to Climate Change and Groundwater -- 2. Climate and Groundwater Primer -- 3. Historical Evidence for Anthropogenic Climate Change and Climate Modeling Basics -- 4. Intergovernmental Panel on Climate Change and Global Climate Change Projections -- 5. Modeling of Climate Change and Aquifer Recharge and Water Levels -- 6. Sea Level Rise and Groundwater -- 7. Climate Change and Small Islands -- 8. Groundwater Related Impacts of Climate Change on Infrastructure -- 9. Adaptation and Resilience Concepts -- 10. Adaptation Options -- 11. Conjunctive Use -- 12. Climate Change Adaptation - Water Management Decision Making Process -- 13. Regional Hydrological Impacts to Climate Changes and Adaptation Actions and Options -- 14. Applied Climate Change Assessment and Adaptation.
    Abstract: This book attempts to bridge the gap between the climate change research and decision-making communities by exploring the impacts of climate change on groundwater from a more applied perspective. Global climate change will impact groundwater demands, quality, and available supplies, and rising sea level may cause water tables to rise, inundating low-lying coastal areas. Groundwater will increasingly be needed to perform a stabilization role in mitigating fluctuations in the supply of surface waters, serving as a buffer against droughts. Climate change has become a frequent subject in the mass media, and the academic literature on the subject is now enormous. An impediment to climate change adaptation with respect to water is a poor link between the climate change research community and the actual decision-makers responsible for water supply planning. Key issues explored are methods for evaluating potential impacts on climate change on local groundwater systems, the adaptation of decision-making process, and how climate change adaptation can be mainstreamed into the water supply planning.
    Type of Medium: Online Resource
    Pages: XV, 350 p. 54 illus., 49 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030668136
    Series Statement: Springer Hydrogeology,
    DDC: 551.48
    Language: English
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